BLASTX 7.6.2
Query= UN14911 /QuerySize=1041
(1040 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q28891|S5A1_MACFA 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=... 83 3e-015
sp|Q68FF9|S5A1_MOUSE 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=... 80 2e-014
sp|P24008|S5A1_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Ra... 80 2e-014
sp|A5PJS2|S5A1_BOVIN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=... 79 4e-014
sp|P18405|S5A1_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=... 79 4e-014
sp|Q28892|S5A2_MACFA 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=... 79 6e-014
sp|P31213|S5A2_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=... 77 2e-013
sp|O18765|S5A2_PIG 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=Su... 76 4e-013
sp|Q99N99|S5A2_MOUSE 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=... 74 2e-012
sp|P31214|S5A2_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=Ra... 73 3e-012
sp|Q0P4J9|S5A3_XENTR 3-oxo-5-alpha-steroid 4-dehydrogenase 3 OS=... 59 7e-008
sp|Q8AVI9|S5A3_XENLA 3-oxo-5-alpha-steroid 4-dehydrogenase 3 OS=... 58 1e-007
sp|Q9UT20|YFY8_SCHPO Uncharacterized protein C9.08c OS=Schizosac... 53 3e-006
>sp|Q28891|S5A1_MACFA 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Macaca
fascicularis GN=SRD5A1 PE=1 SV=1
Length = 263
Score = 83 bits (204), Expect = 3e-015
Identities = 52/181 (28%), Positives = 93/181 (51%), Gaps = 12/181 (6%)
Frame = -2
Query: 700 LLKSALSLHFFKRVLEVMFIHKYSGGM-----SLDVAFTISSGYFSSTALVLYSQSFTLG 536
+L + +H+ R L F+ + M ++ + F +GY S L ++
Sbjct: 90 ILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTFNGYLQSRYLSHWAVYADDW 149
Query: 535 LPQPGLDLKFSGVVMFMVGIVGNLYHHVLLAKLRTEGEGGGKKEYKIPKGGLFDTVICPH 356
+ P + F +++ G++ N++ +L LR G+ G YKIP+GGLF+ V +
Sbjct: 150 VTDPRFLIGFG---LWLAGMLINIHSDHILRNLRKPGDTG----YKIPRGGLFEYVTAAN 202
Query: 355 YMFEVLVFWGFFMISQTIYSLSWAMGTTFYLMGRSYATRRWYLSKFDDFPKHTKALIPFV 176
Y E++ + G+ + S ++ ++A T +L GR+ RWYL KF+++PK K LIPF+
Sbjct: 203 YFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHRWYLQKFEEYPKFRKILIPFL 262
Query: 175 F 173
F
Sbjct: 263 F 263
>sp|Q68FF9|S5A1_MOUSE 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Mus musculus
GN=Srd5a1 PE=2 SV=2
Length = 255
Score = 80 bits (196), Expect = 2e-014
Identities = 42/110 (38%), Positives = 67/110 (60%), Gaps = 4/110 (3%)
Frame = -2
Query: 505 SGVVMFMVGIVGNLYHHVLLAKLRTEGEGGGKKEYKIPKGGLFDTVICPHYMFEVLVFWG 326
+G +++VG+V N++ +L LR GE G YKIP+GGLF+ V +Y E++ + G
Sbjct: 149 TGFALWLVGMVINIHSDHILRNLRKPGETG----YKIPRGGLFEYVSSANYFGELVEWCG 204
Query: 325 FFMISQTIYSLSWAMGTTFYLMGRSYATRRWYLSKFDDFPKHTKALIPFV 176
F + S ++ + +A+ T L R+ +WYL KF+D+PK K LIPF+
Sbjct: 205 FALASWSLQGVVFALFTLCALFTRARQHHQWYLEKFEDYPKTRKILIPFL 254
>sp|P24008|S5A1_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Rattus norvegicus
GN=Srd5a1 PE=1 SV=2
Length = 259
Score = 80 bits (196), Expect = 2e-014
Identities = 42/110 (38%), Positives = 67/110 (60%), Gaps = 4/110 (3%)
Frame = -2
Query: 505 SGVVMFMVGIVGNLYHHVLLAKLRTEGEGGGKKEYKIPKGGLFDTVICPHYMFEVLVFWG 326
+G +++VG+V N++ +L LR GE G YKIP+GGLF+ V +Y E++ + G
Sbjct: 153 TGFALWLVGMVINIHSDHILRNLRKPGETG----YKIPRGGLFEYVSAANYFGELVEWCG 208
Query: 325 FFMISQTIYSLSWAMGTTFYLMGRSYATRRWYLSKFDDFPKHTKALIPFV 176
F + S ++ + +A+ T L+ R+ +WY KF+D+PK K LIPFV
Sbjct: 209 FALASWSLQGVVFALFTLSTLLTRAKQHHQWYHEKFEDYPKSRKILIPFV 258
>sp|A5PJS2|S5A1_BOVIN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Bos taurus
GN=SRD5A1 PE=2 SV=1
Length = 257
Score = 79 bits (194), Expect = 4e-014
Identities = 53/180 (29%), Positives = 90/180 (50%), Gaps = 12/180 (6%)
Frame = -2
Query: 700 LLKSALSLHFFKRVLEVMFIHKYSGGMS-----LDVAFTISSGYFSSTALVLYSQSFTLG 536
+L + +H+ +R L F+ + M L F +GY S L Y+
Sbjct: 84 ILLAMFLVHYAQRSLVFPFLIRGGKPMPLYAFLLAFIFCTYNGYLQSRYLSQYAVYADDW 143
Query: 535 LPQPGLDLKFSGVVMFMVGIVGNLYHHVLLAKLRTEGEGGGKKEYKIPKGGLFDTVICPH 356
L P +G ++++G++ N++ +L LR GE G YKIP+GGLF+ + +
Sbjct: 144 LSDPRF---LTGSALWLIGMLINIHSDHVLRNLRKPGETG----YKIPRGGLFEYISAAN 196
Query: 355 YMFEVLVFWGFFMISQTIYSLSWAMGTTFYLMGRSYATRRWYLSKFDDFPKHTKALIPFV 176
Y EV+ + G+ + S +I ++A+ T L R+ +WY KF+D+PK K +IPF+
Sbjct: 197 YFGEVVEWCGYALASWSIQGWAFAVFTFCVLFTRAQQHHKWYHEKFEDYPKFRKIMIPFL 256
>sp|P18405|S5A1_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 1 OS=Homo sapiens
GN=SRD5A1 PE=1 SV=1
Length = 259
Score = 79 bits (194), Expect = 4e-014
Identities = 38/110 (34%), Positives = 66/110 (60%), Gaps = 4/110 (3%)
Frame = -2
Query: 502 GVVMFMVGIVGNLYHHVLLAKLRTEGEGGGKKEYKIPKGGLFDTVICPHYMFEVLVFWGF 323
G +++ G++ N++ +L LR G+ G YKIP+GGLF+ V +Y E++ + G+
Sbjct: 154 GFGLWLTGMLINIHSDHILRNLRKPGDTG----YKIPRGGLFEYVTAANYFGEIMEWCGY 209
Query: 322 FMISQTIYSLSWAMGTTFYLMGRSYATRRWYLSKFDDFPKHTKALIPFVF 173
+ S ++ ++A T +L GR+ WYL KF+++PK K +IPF+F
Sbjct: 210 ALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF 259
>sp|Q28892|S5A2_MACFA 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=Macaca
fascicularis GN=SRD5A2 PE=1 SV=1
Length = 254
Score = 79 bits (192), Expect = 6e-014
Identities = 48/147 (32%), Positives = 86/147 (58%), Gaps = 9/147 (6%)
Frame = -2
Query: 610 VAFTISSGYFSSTALVLYSQSFTLGLPQPGLDLKFS-GVVMFMVGIVGNLYHHVLLAKLR 434
+AF +G+ S L+ Y + G D++F GV +F++G+ N++ +L +LR
Sbjct: 116 IAFCAGNGFLQSYYLI-YCAEYPDGW---YTDIRFCLGVFLFILGMGVNIHSDYILRQLR 171
Query: 433 TEGEGGGKKEYKIPKGGLFDTVICPHYMFEVLVFWGFFMISQTIYSLSWAMGTTFYLMGR 254
GE Y+IPKGGLF V +++ E++ + G+ + + ++ +L++A + +L R
Sbjct: 172 KPGE----ITYRIPKGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSVCFLGLR 227
Query: 253 SYATRRWYLSKFDDFPKHTKALIPFVF 173
++ R+YL F+D+PK KALIPF+F
Sbjct: 228 AFHHHRFYLKMFEDYPKSRKALIPFIF 254
>sp|P31213|S5A2_HUMAN 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=Homo sapiens
GN=SRD5A2 PE=1 SV=1
Length = 254
Score = 77 bits (187), Expect = 2e-013
Identities = 41/116 (35%), Positives = 75/116 (64%), Gaps = 5/116 (4%)
Frame = -2
Query: 517 DLKFS-GVVMFMVGIVGNLYHHVLLAKLRTEGEGGGKKEYKIPKGGLFDTVICPHYMFEV 341
D++FS GV +F++G+ N++ +L +LR GE Y+IP+GGLF V +++ E+
Sbjct: 143 DIRFSLGVFLFILGMGINIHSDYILRQLRKPGE----ISYRIPQGGLFTYVSGANFLGEI 198
Query: 340 LVFWGFFMISQTIYSLSWAMGTTFYLMGRSYATRRWYLSKFDDFPKHTKALIPFVF 173
+ + G+ + + ++ +L++A + +L R++ R+YL F+D+PK KALIPF+F
Sbjct: 199 IEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF 254
>sp|O18765|S5A2_PIG 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=Sus scrofa
GN=SRD5A2 PE=2 SV=2
Length = 254
Score = 76 bits (185), Expect = 4e-013
Identities = 41/116 (35%), Positives = 75/116 (64%), Gaps = 5/116 (4%)
Frame = -2
Query: 517 DLKFS-GVVMFMVGIVGNLYHHVLLAKLRTEGEGGGKKEYKIPKGGLFDTVICPHYMFEV 341
D++FS GV +F++G+ N++ +L +LR GE YKIP+GGLF V +++ E+
Sbjct: 143 DIRFSLGVFLFILGMGINIHSDYILRQLRKPGE----VIYKIPQGGLFTYVSGANFLGEI 198
Query: 340 LVFWGFFMISQTIYSLSWAMGTTFYLMGRSYATRRWYLSKFDDFPKHTKALIPFVF 173
+ + G+ + + ++ +L++A + +L R++ R+Y+ F+D+PK KALIPF+F
Sbjct: 199 IEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYVKMFEDYPKSRKALIPFIF 254
>sp|Q99N99|S5A2_MOUSE 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=Mus musculus
GN=Srd5a2 PE=2 SV=1
Length = 254
Score = 74 bits (180), Expect = 2e-012
Identities = 40/116 (34%), Positives = 72/116 (62%), Gaps = 5/116 (4%)
Frame = -2
Query: 517 DLKFS-GVVMFMVGIVGNLYHHVLLAKLRTEGEGGGKKEYKIPKGGLFDTVICPHYMFEV 341
D++FS GV F++G+ N++ +L +LR GE Y+IP+GGLF V +++ E+
Sbjct: 143 DMRFSVGVFFFILGMGINIHSDCMLRQLRKPGE----VIYRIPQGGLFTYVSGANFLGEI 198
Query: 340 LVFWGFFMISQTIYSLSWAMGTTFYLMGRSYATRRWYLSKFDDFPKHTKALIPFVF 173
+ + G+ + + ++ + ++A T +L +++ R+YL F D+PK KALIPF+F
Sbjct: 199 IEWMGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFKDYPKSRKALIPFIF 254
>sp|P31214|S5A2_RAT 3-oxo-5-alpha-steroid 4-dehydrogenase 2 OS=Rattus norvegicus
GN=Srd5a2 PE=1 SV=1
Length = 254
Score = 73 bits (177), Expect = 3e-012
Identities = 40/116 (34%), Positives = 72/116 (62%), Gaps = 5/116 (4%)
Frame = -2
Query: 517 DLKFS-GVVMFMVGIVGNLYHHVLLAKLRTEGEGGGKKEYKIPKGGLFDTVICPHYMFEV 341
D++FS GV +F++G+ N++ L +LR GE Y+IP+GGLF V +++ E+
Sbjct: 143 DVRFSFGVFLFILGMGINIHSDYTLRQLRKPGE----VIYRIPRGGLFTYVSGANFLGEI 198
Query: 340 LVFWGFFMISQTIYSLSWAMGTTFYLMGRSYATRRWYLSKFDDFPKHTKALIPFVF 173
+ + G+ + + ++ + ++A T +L +++ R+YL F D+PK KALIPF+F
Sbjct: 199 IEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFKDYPKSRKALIPFIF 254
>sp|Q0P4J9|S5A3_XENTR 3-oxo-5-alpha-steroid 4-dehydrogenase 3 OS=Xenopus
tropicalis GN=srd5a3 PE=2 SV=1
Length = 308
Score = 59 bits (140), Expect = 7e-008
Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 5/114 (4%)
Frame = -2
Query: 502 GVVMFMVGIVGNLYHHVLLAKLRTEGEGGG-KKEYKIPKGGLFDTVICPHYMFEVLVFWG 326
G+ +++ + H +LA LR G + +P G F+ V CPHY E+L++
Sbjct: 196 GLALYIWASLHQYRCHCILAGLRKSASGNVINLNHSVPCGDWFERVSCPHYFAELLIYVS 255
Query: 325 FFMISQTIYSLSWAMGTTFYLMGRSYAT---RRWYLSKFDDFPKHTKALIPFVF 173
++ + ++ W + + L+ ++ A +Y KFD +P H KA IPF+F
Sbjct: 256 IAVVFGLLNTIWWLV-VLYVLLNQALAALLCHEFYHEKFDTYPIHRKAFIPFIF 308
>sp|Q8AVI9|S5A3_XENLA 3-oxo-5-alpha-steroid 4-dehydrogenase 3 OS=Xenopus laevis
GN=srd5a3 PE=2 SV=1
Length = 319
Score = 58 bits (138), Expect = 1e-007
Identities = 31/114 (27%), Positives = 57/114 (50%), Gaps = 5/114 (4%)
Frame = -2
Query: 502 GVVMFMVGIVGNLYHHVLLAKLRTEGEGG-GKKEYKIPKGGLFDTVICPHYMFEVLVFWG 326
G+ +++ + H +LA LR G ++ +P G F+ V CPHY E+L++
Sbjct: 207 GLTLYVWASLHQYTCHCILADLRKSASGAIINLKHAVPTGDWFEKVSCPHYFAELLIYLS 266
Query: 325 FFMISQTIYSLSWAMGTTFYLMGRSYAT---RRWYLSKFDDFPKHTKALIPFVF 173
++ + ++ W + + L+ ++ A +Y KFD +P H KA IP +F
Sbjct: 267 IAVVFGLLNTIWWLV-VLYVLLSQALAAVLCHEFYHEKFDSYPIHRKAFIPLIF 319
>sp|Q9UT20|YFY8_SCHPO Uncharacterized protein C9.08c OS=Schizosaccharomyces
pombe GN=SPAC9.08c PE=2 SV=1
Length = 282
Score = 53 bits (126), Expect = 3e-006
Identities = 24/78 (30%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Frame = -2
Query: 403 YKIPKGGLFDTVICPHYMFEVLVFWGFFMISQTIYSLSW--AMGTTFYLMGRSYATRRWY 230
Y+IP GGLF V CP+Y E + ++G ++ + W + ++ R+ +WY
Sbjct: 204 YRIPYGGLFQYVSCPNYFCEWIEWFGCYLAAGPSAEPFWWFFLSEILLMLPRALKAHQWY 263
Query: 229 LSKFDDFPKHTKALIPFV 176
KF +P + +A+IPF+
Sbjct: 264 CKKFPKYPANRRAIIPFL 281
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,727,594,170
Number of Sequences: 518415
Number of Extensions: 61727594170
Number of Successful Extensions: 397900902
Number of sequences better than 0.0: 0
|
