BLASTX 7.6.2
Query= UN14946 /QuerySize=1260
(1259 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9ERI6|RDH14_MOUSE Retinol dehydrogenase 14 OS=Mus musculus G... 201 8e-051
sp|Q9HBH5|RDH14_HUMAN Retinol dehydrogenase 14 OS=Homo sapiens G... 201 1e-050
sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 OS=Homo sapiens G... 198 7e-050
sp|Q8CEE7|RDH13_MOUSE Retinol dehydrogenase 13 OS=Mus musculus G... 197 2e-049
sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member ... 191 1e-047
sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus ... 181 9e-045
sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pong... 180 3e-044
sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo... 179 3e-044
sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Dani... 177 2e-043
sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gall... 176 5e-043
sp|Q8VBZ0|DHRSX_MOUSE Dehydrogenase/reductase SDR family member ... 173 3e-042
sp|O74959|YJCD_SCHPO Uncharacterized oxidoreductase C736.13 OS=S... 149 4e-035
sp|Q9VLU5|WWOX_DROME WW domain-containing oxidoreductase OS=Dros... 147 2e-034
sp|Q9QYF1|RDH11_MOUSE Retinol dehydrogenase 11 OS=Mus musculus G... 130 2e-029
sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 OS=Mus musculus G... 130 3e-029
sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 OS=Bos taurus GN=... 128 1e-028
sp|Q8TC12|RDH11_HUMAN Retinol dehydrogenase 11 OS=Homo sapiens G... 125 8e-028
sp|Q03326|OXIR_STRAT Probable oxidoreductase OS=Streptomyces ant... 123 4e-027
sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 OS=Homo sapiens G... 123 4e-027
>sp|Q9ERI6|RDH14_MOUSE Retinol dehydrogenase 14 OS=Mus musculus GN=Rdh14 PE=1
SV=1
Length = 334
Score = 201 bits (511), Expect = 8e-051
Identities = 115/295 (38%), Positives = 175/295 (59%), Gaps = 23/295 (7%)
Frame = +2
Query: 221 TAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILRQ----------NANA 370
T +ITG G+G TA + + GA V++G R+ AE+A ++ ++ +
Sbjct: 46 TVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRQELCQAGGAGPDGTDG 105
Query: 371 RVTLIHLDLSSFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFATNHMG 550
++ + LDL+S +S++AF ++ L++LINNAGV CPY +EDG E+QF NH+G
Sbjct: 106 QLVVKELDLASLRSVRAFCQELLQEEPRLDVLINNAGVFHCPYTKTEDGFEMQFGVNHLG 165
Query: 551 HFLLTNLLLDTMKNTAKTSGVEGRILNLSSIAHIYTYQEGIQFDSINDICSYSDKRAYGQ 730
HFLLTNLLL +K++A + RI+ +SS +Y Y E I F+ +N SY+ Y +
Sbjct: 166 HFLLTNLLLGLLKSSAPS-----RIVVVSS--KLYKYGE-INFEDLNSEQSYNKSFCYSR 217
Query: 731 SKLANILHANKLSRQLQEEGVNITVNSVHPGLILTNLFQHTALLMRFLKFFSFYLW---K 901
SKLANIL +L+R+L EG N+TVN +HPG++ TNL +H + + F+ W K
Sbjct: 218 SKLANILFTRELARRL--EGTNVTVNVLHPGIVRTNLGRHIHIPLLARPLFNLVSWAFFK 275
Query: 902 NIPQGAATTCYVALHPSLKEVTGEYFADCNEVTPSKLARDETLAQKLWDFSVKLI 1066
+GA T+ Y+A P ++ V+G YF DC E A DE++A+KLWD S ++
Sbjct: 276 TPLEGAQTSIYLACSPDVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMV 330
>sp|Q9HBH5|RDH14_HUMAN Retinol dehydrogenase 14 OS=Homo sapiens GN=RDH14 PE=1
SV=1
Length = 336
Score = 201 bits (509), Expect = 1e-050
Identities = 118/298 (39%), Positives = 175/298 (58%), Gaps = 26/298 (8%)
Frame = +2
Query: 221 TAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEI---LRQNAN-------- 367
T +ITG G+G TA + + GA V++G R+ AE+A ++ LRQ A
Sbjct: 45 TVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVS 104
Query: 368 --ARVTLIHLDLSSFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFATN 541
+ + LDL+S +S++AF ++ L++LINNAG+ CPY +EDG E+QF N
Sbjct: 105 GVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVN 164
Query: 542 HMGHFLLTNLLLDTMKNTAKTSGVEGRILNLSSIAHIYTYQEGIQFDSINDICSYSDKRA 721
H+GHFLLTNLLL +K++A + RI+ +SS +Y Y + I FD +N SY+
Sbjct: 165 HLGHFLLTNLLLGLLKSSAPS-----RIVVVSS--KLYKYGD-INFDDLNSEQSYNKSFC 216
Query: 722 YGQSKLANILHANKLSRQLQEEGVNITVNSVHPGLILTNLFQHTALLMRFLKFFSFYLW- 898
Y +SKLANIL +L+R+L EG N+TVN +HPG++ TNL +H + + F+ W
Sbjct: 217 YSRSKLANILFTRELARRL--EGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWA 274
Query: 899 --KNIPQGAATTCYVALHPSLKEVTGEYFADCNEVTPSKLARDETLAQKLWDFSVKLI 1066
K +GA T+ Y+A P ++ V+G YF DC E A DE++A+KLWD S ++
Sbjct: 275 FFKTPVEGAQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMV 332
>sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1
SV=2
Length = 331
Score = 198 bits (503), Expect = 7e-050
Identities = 120/288 (41%), Positives = 172/288 (59%), Gaps = 16/288 (5%)
Frame = +2
Query: 221 TAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLIHLDLS 400
T I+TG GIG +TA +A+RG ++++ R+M E A +I + N V HLDL+
Sbjct: 40 TVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLA 99
Query: 401 SFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFATNHMGHFLLTNLLLD 580
S KSI+ F ++ILINNAGVM CP+ +EDG E+QF NH+GHFLLTNLLLD
Sbjct: 100 SLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLD 159
Query: 581 TMKNTAKTSGVEGRILNLSSIAHIYTYQEGIQFDSIN-DICSYSDKRAYGQSKLANILHA 757
+K +A + RI+NLSS+AH+ + I FD +N Y+ K AY QSKLA +L
Sbjct: 160 KLKASAPS-----RIINLSSLAHVAGH---IDFDDLNWQTRKYNTKAAYCQSKLAIVLFT 211
Query: 758 NKLSRQLQEEGVNITVNSVHPGLILTNLFQHTALLMRFLKFFS----FYLWKNIPQGAA- 922
+LSR+LQ GV TVN++HPG+ T L +HT + + F+L P+ AA
Sbjct: 212 KELSRRLQGSGV--TVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAAQ 269
Query: 923 TTCYVALHPSLKEVTGEYFADCNEVTPSKLARDETLAQKLWDFSVKLI 1066
+ Y+A+ L +V+G+YF + P+ A DE +A++LW S +L+
Sbjct: 270 PSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLV 317
>sp|Q8CEE7|RDH13_MOUSE Retinol dehydrogenase 13 OS=Mus musculus GN=Rdh13 PE=2
SV=1
Length = 334
Score = 197 bits (499), Expect = 2e-049
Identities = 120/288 (41%), Positives = 171/288 (59%), Gaps = 16/288 (5%)
Frame = +2
Query: 221 TAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLIHLDLS 400
T I+TG GIG +TA +A+RG +V++ R+M E A +I + N RV LDL+
Sbjct: 40 TVIVTGANTGIGKQTALELAKRGGNVILACRDMEKCEVAAKDIRGETLNPRVRAERLDLA 99
Query: 401 SFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFATNHMGHFLLTNLLLD 580
S KSI+ F R ++IL+NNA VM CP+ +EDG E+QF N++GHFLLTNLLLD
Sbjct: 100 SLKSIREFARKVIKEEERVDILVNNAAVMRCPHWTTEDGFEMQFGVNYLGHFLLTNLLLD 159
Query: 581 TMKNTAKTSGVEGRILNLSSIAHIYTYQEGIQFDSIN-DICSYSDKRAYGQSKLANILHA 757
+K +A + RI+NLSS+AH+ + I F+ +N + Y K AY QSKLA +L
Sbjct: 160 KLKASAPS-----RIINLSSLAHVAGH---IDFEDLNWQMKKYDTKAAYCQSKLAVVLFT 211
Query: 758 NKLSRQLQEEGVNITVNSVHPGLILTNLFQHT-----ALLMRFLKFFSFYLWKNIPQGAA 922
+LS +LQ GV TVN++HPG+ T L +HT A L F + L+K+ A
Sbjct: 212 KELSHRLQGSGV--TVNALHPGVARTELGRHTGMHNSAFSGFMLGPFFWLLFKSPQLAAQ 269
Query: 923 TTCYVALHPSLKEVTGEYFADCNEVTPSKLARDETLAQKLWDFSVKLI 1066
+ Y+A+ L+ V+G+YF E PS A DE +A++LW S +L+
Sbjct: 270 PSTYLAVAEELENVSGKYFDGLREKAPSPEAEDEEVARRLWTESARLV 317
>sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member on chromosome X
OS=Homo sapiens GN=DHRSX PE=2 SV=2
Length = 330
Score = 191 bits (484), Expect = 1e-047
Identities = 107/281 (38%), Positives = 159/281 (56%), Gaps = 5/281 (1%)
Frame = +2
Query: 224 AIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLIHLDLSS 403
AI+TGGT GIG TA +A+ G HV+I N A++ ++I + N +V ++ DL+S
Sbjct: 46 AIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLAS 105
Query: 404 FKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFATNHMGHFLLTNLLLDT 583
SI+ FV+ F +PL++LINNAGVM P + + DG E F N++GHFLLTNLLLDT
Sbjct: 106 MTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLLDT 165
Query: 584 MKNTAKTSGVEGRILNLSSIAHIYTYQEGIQFDSINDICSYSDKRAYGQSKLANILHANK 763
+K + + G R++ +SS H Y + D + YS AY QSKLA +L
Sbjct: 166 LKESG-SPGHSARVVTVSSATH---YVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYH 221
Query: 764 LSRQLQEEGVNITVNSVHPGLILTNLFQHTALLMRFL-KFFSFYLWKNIPQGAATTCYVA 940
L R L EG ++T N V PG++ T++++H R K + L+K +GA T+ Y A
Sbjct: 222 LQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAWTSIYAA 281
Query: 941 LHPSLKEVTGEYFADCNEVTPSKLARDETLAQKLWDFSVKL 1063
+ P L+ V G Y + E + ++ L Q+LW S ++
Sbjct: 282 VTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEM 322
>sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus musculus
GN=Wwox PE=1 SV=1
Length = 414
Score = 181 bits (459), Expect = 9e-045
Identities = 110/314 (35%), Positives = 169/314 (53%), Gaps = 28/314 (8%)
Frame = +2
Query: 164 FGSASTAEEVTQGIDATHLTAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKT 343
+ ++TA E+ QG D T ++TG GIG ETA A GAHV++ RN+ A +A +
Sbjct: 107 YDGSTTAMEILQGRDFTGKVVLVTGANSGIGFETAKSFALHGAHVILACRNLSRASEAVS 166
Query: 344 EILRQNANARVTLIHLDLSSFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIE 523
IL + A+V + LDL+ +S++ F F A ++ L++L+ NAG P+ L++DG+E
Sbjct: 167 RILEEWHKAKVEAMTLDLAVLRSVQHFAEAFKAKNVSLHVLVCNAGTFALPWGLTKDGLE 226
Query: 524 LQFATNHMGHFLLTNLLLDTMKNTAKTSGVEGRILNLSSIAHIYTYQEGIQFDSINDI-- 697
F NH+GHF L LL D + ++ R++ +SS +H +F IND
Sbjct: 227 TTFQVNHLGHFYLVQLLQDVLCRSS-----PARVIVVSSESH--------RFTDINDSSG 273
Query: 698 -----------CSYSDKRAYGQSKLANILHANKLSRQLQEEGVNITVNSVHPGLILTNLF 844
Y AY +SKL NIL +N+L R+L GV T N+VHPG ++ +
Sbjct: 274 KLDLSRLSPPRSDYWAMLAYNRSKLCNILFSNELHRRLSPRGV--TSNAVHPGNMMYSAI 331
Query: 845 QHTALLMRFLKFFSFYLWKNIPQGAATTCYVALHPSLKEVTGEYFADCNEVTPSKLARDE 1024
+ + + L + K++ QGAATT Y A+ P L+ + G YF +C PS+ A+ E
Sbjct: 332 HRNSWVYKLLFTLARPFTKSMQQGAATTVYCAVAPELEGLGGMYFNNCCRCLPSEEAQSE 391
Query: 1025 TLAQKLWDFSVKLI 1066
A+ LW+ S +LI
Sbjct: 392 ETARALWELSERLI 405
>sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pongo abelii
GN=WWOX PE=2 SV=1
Length = 414
Score = 180 bits (455), Expect = 3e-044
Identities = 109/306 (35%), Positives = 167/306 (54%), Gaps = 12/306 (3%)
Frame = +2
Query: 164 FGSASTAEEVTQGIDATHLTAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKT 343
+ ++TA E+ QG D T ++TG GIG ETA A GAHV++ RNM A +A +
Sbjct: 107 YDGSTTALEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVS 166
Query: 344 EILRQNANARVTLIHLDLSSFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIE 523
IL + A+V + LDL+ +S++ F F A ++PL++L+ NA P+ L++DG+E
Sbjct: 167 RILEEWHKAKVEAVTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLE 226
Query: 524 LQFATNHMGHFLLTNLLLDTMKNTAKTSGVEGRILNLSSIAHIYTYQEG----IQFDSIN 691
F NH+GHF L LL D + +A R++ +SS +H +T + F ++
Sbjct: 227 TTFQVNHLGHFYLVQLLQDVLCRSA-----PARVIVVSSESHRFTDINDSLGKLDFSRLS 281
Query: 692 DICS-YSDKRAYGQSKLANILHANKLSRQLQEEGVNITVNSVHPGLILTNLFQHTALLMR 868
+ Y AY +SKL N+L +N+L R+L GV T N+VHPG ++ + + +
Sbjct: 282 PTKNDYWAMLAYNRSKLCNVLFSNELHRRLSPRGV--TSNAVHPGNMMYSNIHRSWWVYT 339
Query: 869 FLKFFSFYLWKNIPQGAATTCYVALHPSLKEVTGEYFADCNEVTPSKLARDETLAQKLWD 1048
L + K++ QGAATT Y A P L+ + G YF +C PS A+ E A+ LW
Sbjct: 340 LLFTLARPFTKSMQQGAATTVYCAAAPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWA 399
Query: 1049 FSVKLI 1066
S +LI
Sbjct: 400 LSERLI 405
>sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo sapiens
GN=WWOX PE=1 SV=1
Length = 414
Score = 179 bits (454), Expect = 3e-044
Identities = 110/306 (35%), Positives = 167/306 (54%), Gaps = 12/306 (3%)
Frame = +2
Query: 164 FGSASTAEEVTQGIDATHLTAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKT 343
+ ++TA E+ QG D T ++TG GIG ETA A GAHV++ RNM A +A +
Sbjct: 107 YDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVS 166
Query: 344 EILRQNANARVTLIHLDLSSFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIE 523
IL + A+V + LDL+ +S++ F F A ++PL++L+ NA P+ L++DG+E
Sbjct: 167 RILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLE 226
Query: 524 LQFATNHMGHFLLTNLLLDTMKNTAKTSGVEGRILNLSSIAHIYTYQEG----IQFDSIN 691
F NH+GHF L LL D + +A R++ +SS +H +T + F ++
Sbjct: 227 TTFQVNHLGHFYLVQLLQDVLCRSA-----PARVIVVSSESHRFTDINDSLGKLDFSRLS 281
Query: 692 DICS-YSDKRAYGQSKLANILHANKLSRQLQEEGVNITVNSVHPGLILTNLFQHTALLMR 868
+ Y AY +SKL NIL +N+L R+L GV T N+VHPG ++ + + +
Sbjct: 282 PTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGV--TSNAVHPGNMMYSNIHRSWWVYT 339
Query: 869 FLKFFSFYLWKNIPQGAATTCYVALHPSLKEVTGEYFADCNEVTPSKLARDETLAQKLWD 1048
L + K++ QGAATT Y A P L+ + G YF +C PS A+ E A+ LW
Sbjct: 340 LLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWA 399
Query: 1049 FSVKLI 1066
S +LI
Sbjct: 400 LSERLI 405
>sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Danio rerio GN=wwox
PE=2 SV=1
Length = 412
Score = 177 bits (447), Expect = 2e-043
Identities = 109/313 (34%), Positives = 168/313 (53%), Gaps = 12/313 (3%)
Frame = +2
Query: 155 PSGFGSASTAEEVTQGIDATHLTAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEK 334
P + + A E+ G D + I+TG GIG ETA A GAHV++ RN A K
Sbjct: 101 PKRYDGNTGALEILHGQDLSDKVIIVTGANSGIGFETARSFALHGAHVILACRNQSRASK 160
Query: 335 AKTEILRQNANARVTLIHLDLSSFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSED 514
A + I+ + + ARV ++ LDL+S +S++ F F A LPL++L+ NA V P++L+ED
Sbjct: 161 AASLIMGEWSKARVEVLPLDLASLRSVRQFAELFKATKLPLHVLVCNAAVCSQPWRLTED 220
Query: 515 GIELQFATNHMGHFLLTNLLLDTMKNTAKTSGVEGRILNLSSIAHIYTYQEGIQFDSIND 694
G E F H+GHFLL LL D ++ +A R++ +SS +H +T + D
Sbjct: 221 GFESTFQICHLGHFLLVQLLQDVLRLSA-----PARVVVVSSESHRFTDLLDSCGNLDLD 275
Query: 695 ICSYSDKR-----AYGQSKLANILHANKLSRQLQEEGVNITVNSVHPGLILTNLFQHTAL 859
+ S K AY ++KL N+L +++L R++ G I N++HPG ++ +
Sbjct: 276 LLSPPQKNYWSLLAYNRAKLCNLLFSSELHRRMSPHG--ICCNALHPGSMMFTSIHRSWW 333
Query: 860 LMRFLKFFSFYLWKNIPQGAATTCYVALHPSLKEVTGEYFADCNEVTPSKLARDETLAQK 1039
L+ L + K++ QGAATT Y A+ P L+ + G YF +C PS A+D A
Sbjct: 334 LLTLLFSLARPFTKSMQQGAATTVYCAVAPELEGIGGMYFNNCFRCLPSPQAQDPAAALS 393
Query: 1040 LWDFSVKLINSVS 1078
LW+ S +L+ S
Sbjct: 394 LWELSERLVQERS 406
>sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gallus gallus
GN=WWOX PE=2 SV=2
Length = 414
Score = 176 bits (444), Expect = 5e-043
Identities = 112/302 (37%), Positives = 163/302 (53%), Gaps = 12/302 (3%)
Frame = +2
Query: 176 STAEEVTQGIDATHLTAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILR 355
STA E+ QG D + IITG GIG ETA A GA+V++ RNM A IL
Sbjct: 111 STAMEILQGRDLSGKVIIITGANSGIGFETAKSFALHGAYVILACRNMSRGNDAVQRILE 170
Query: 356 QNANARVTLIHLDLSSFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFA 535
+ A+V + LDL+S +S++ F F + ++PL+IL+ NA + + L+EDG+E F
Sbjct: 171 EWHKAKVEAMTLDLASLRSVQNFAEAFKSKNMPLHILVCNAAIFGSSWCLTEDGLESTFQ 230
Query: 536 TNHMGHFLLTNLLLDTMKNTAKTSGVEGRILNLSSIAHIYTYQEGIQFDSINDICSYSDK 715
NH+GHF L LL D ++ ++ R++ +SS +H +T + + S S K
Sbjct: 231 VNHLGHFYLVQLLEDILRRSS-----PARVVVVSSESHRFTEIKDSSGKLDFSLLSPSKK 285
Query: 716 R-----AYGQSKLANILHANKLSRQLQEEGVNITVNSVHPGLILTNLFQHTALLMRFLKF 880
AY +SKL NIL +N+L+R+L GV T NSVHPG ++ + + L
Sbjct: 286 EYWAMLAYNRSKLCNILFSNELNRRLSPHGV--TSNSVHPGNMIYSSIHRNWWVYTLLFT 343
Query: 881 FSFYLWKNIPQGAATTCYVALHPSLKEVTGEYFADCNEVTPSKLARDETLAQKLWDFSVK 1060
+ K++ QGAATT Y A L+ + G YF +C PS AR+E A LW+ S +
Sbjct: 344 LARPFTKSMQQGAATTVYCATAAELEGLGGMYFNNCCRCLPSAEARNELTAVALWELSER 403
Query: 1061 LI 1066
LI
Sbjct: 404 LI 405
>sp|Q8VBZ0|DHRSX_MOUSE Dehydrogenase/reductase SDR family member on chromosome X
homolog OS=Mus musculus GN=Dhrsx PE=2 SV=2
Length = 335
Score = 173 bits (437), Expect = 3e-042
Identities = 104/281 (37%), Positives = 151/281 (53%), Gaps = 5/281 (1%)
Frame = +2
Query: 224 AIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLIHLDLSS 403
AI+TG T GIG TA +A+ G VV+ + ++ + I + + R + LDL+S
Sbjct: 46 AIVTGATAGIGRSTARQLARLGMCVVVAGNDEHRGQEVVSSIRAEMGSDRAHFLPLDLAS 105
Query: 404 FKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFATNHMGHFLLTNLLLDT 583
S++ F RDF AL LPL++L+NNAGVM P +EDG E N +GHFLLT LLL
Sbjct: 106 LASVRGFARDFQALGLPLHLLVNNAGVMLEPRAETEDGFERHLGVNFLGHFLLTLLLLPA 165
Query: 584 MKNTAKTSGVEGRILNLSSIAHIYTYQEGIQFDSINDICSYSDKRAYGQSKLANILHANK 763
+ + SG EGR + ++ Y + ++ +YS AY QSKLA L A +
Sbjct: 166 L----RASGAEGRGSRVVTVGSATHYVGTVDMADLHGRHAYSPYAAYAQSKLALALFALQ 221
Query: 764 LSRQLQEEGVNITVNSVHPGLILTNLFQHTALLMRFLK-FFSFYLWKNIPQGAATTCYVA 940
L R L G +T N PG++ T L++H ++R K F + ++K+ +GA T Y A
Sbjct: 222 LQRILDARGDPVTSNMADPGVVDTELYRHAGWVLRTAKRFLGWLVFKSPEEGAWTLVYAA 281
Query: 941 LHPSLKEVTGEYFADCNEVTPSKLARDETLAQKLWDFSVKL 1063
P L+ V G Y D E P ARD+ L ++LW ++L
Sbjct: 282 AAPELEGVGGRYLRDEAEAEPLGTARDQELQRRLWAEGLRL 322
>sp|O74959|YJCD_SCHPO Uncharacterized oxidoreductase C736.13
OS=Schizosaccharomyces pombe GN=SPCC736.13 PE=2 SV=1
Length = 339
Score = 149 bits (376), Expect = 4e-035
Identities = 98/296 (33%), Positives = 161/296 (54%), Gaps = 8/296 (2%)
Frame = +2
Query: 206 DATHLTAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLI 385
D T A++TG +GGIG TA +A++GA V + RN +K +I + ++++ +
Sbjct: 39 DLTGKVALVTGSSGGIGYVTALELARKGAKVYLAGRNEEKYQKVMKQIHDEVRHSKIRFL 98
Query: 386 HLDLSSFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFATNHMGHFLLT 565
LDL F+S+ F A L+IL+NNAG+M P++L++DG ELQ TN++ H+L T
Sbjct: 99 RLDLLDFESVYQAAESFIAKEEKLHILVNNAGIMNPPFELTKDGYELQIQTNYLSHYLFT 158
Query: 566 NLLLDTMKNTAKTSGV-EGRILNLSSIAHIYTYQEGIQFDSIN-DICSYSDKRAYGQSKL 739
LLL T++ TA+ + RI++++SIA++ GI F +N YGQSK
Sbjct: 159 ELLLPTLRRTAEECRPGDVRIVHVASIAYLQAPYSGIYFPDLNLPHVLLGTFARYGQSKY 218
Query: 740 ANILHANKLSRQLQEEGVNITVNSVHPGLILTNL--FQHTALLMRFLKFFSFYLWKNIPQ 913
A IL++ L+++L++ G+ S+HPG+I T L + T L K YL + +
Sbjct: 219 AQILYSIALAKRLEKYGIYSV--SLHPGVIRTELTRYSPTFALKLLEKSVFQYLLLDPIR 276
Query: 914 GAATTCYVALHP--SLKEVTGEYFADCNEVTPSKLARDETLAQKLWDFSVKLINSV 1075
GA T+ Y A P S + + G YF + A D+ ++L+ ++ K+ +
Sbjct: 277 GAMTSLYAATSPEISKEHLNGAYFTAIAQRGILHRAHDDAFVEELYRYTHKIFEDL 332
>sp|Q9VLU5|WWOX_DROME WW domain-containing oxidoreductase OS=Drosophila
melanogaster GN=Wwox PE=2 SV=1
Length = 409
Score = 147 bits (369), Expect = 2e-034
Identities = 104/307 (33%), Positives = 158/307 (51%), Gaps = 16/307 (5%)
Frame = +2
Query: 164 FGSASTAEEVTQGIDATHLTAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKT 343
F S STA +V G D TA+ITG GIG ETA +A G ++ RN AE A
Sbjct: 104 FDSCSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIE 163
Query: 344 EILRQN--ANARVTLIHLDLSSFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDG 517
I ++ A +R LDLSS +S++ FV + ++ LI NAGV PY + DG
Sbjct: 164 RIAQERPAARSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDG 223
Query: 518 IELQFATNHMGHFLLTNLLLDTMKNTAKTSGVEGRILNLSSIAHIYTYQEGIQFDSINDI 697
+E F +H+ HF LT L L+T+ + + RI+ LSS +H + ++ +++ +
Sbjct: 224 LETTFQVSHLSHFYLT-LQLETLFD------YKTRIIVLSSESHRFA-NLPVENLAVHHL 275
Query: 698 C----SYSDKRAYGQSKLANILHANKLSRQLQEEGVNITVNSVHPGLILTNLFQHTALLM 865
Y AY +KL N+L A +L+++ ++ G I+V S+HPG ++++
Sbjct: 276 SPPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRG--ISVFSLHPGNMVSSDLSRNYWFY 333
Query: 866 RFLKFFSFYLWKNIPQGAATTCYVALHPSLKEVTGEYFADCNEVTPSKLARDETLAQKLW 1045
R L K++ Q AAT+ Y A L ++G YF +C PSKL++ L Q+LW
Sbjct: 334 RLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFNNCFFCEPSKLSKSAALQQQLW 393
Query: 1046 DFSVKLI 1066
S LI
Sbjct: 394 KLSENLI 400
>sp|Q9QYF1|RDH11_MOUSE Retinol dehydrogenase 11 OS=Mus musculus GN=Rdh11 PE=2
SV=2
Length = 316
Score = 130 bits (326), Expect = 2e-029
Identities = 70/152 (46%), Positives = 94/152 (61%), Gaps = 5/152 (3%)
Frame = +2
Query: 194 TQGIDATHLTAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILRQNANAR 373
T + AI+TG GIG ETA +AQRGA V + R++ E A EI N++
Sbjct: 31 TSNVQLPGKVAIVTGANTGIGKETAKDLAQRGARVYLACRDVDKGELAAREIQAVTGNSQ 90
Query: 374 VTLIHLDLSSFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFATNHMGH 553
V + LDL+ KSI+AF +DF A L++LINNAGVM CPY + DG E+ NH+GH
Sbjct: 91 VFVRKLDLADTKSIRAFAKDFLAEEKHLHLLINNAGVMMCPYSKTADGFEMHIGVNHLGH 150
Query: 554 FLLTNLLLDTMKNTAKTSGVEGRILNLSSIAH 649
FLLT+LLL+ +K +A + RI+NLSS+ H
Sbjct: 151 FLLTHLLLEKLKESAPS-----RIVNLSSLGH 177
>sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 OS=Mus musculus GN=Rdh12 PE=2
SV=1
Length = 316
Score = 130 bits (325), Expect = 3e-029
Identities = 72/153 (47%), Positives = 92/153 (60%), Gaps = 5/153 (3%)
Frame = +2
Query: 194 TQGIDATHLTAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILRQNANAR 373
T + +ITG GIG ETA +A+RGA V I R++ E A +EI N++
Sbjct: 32 TTNVQIPGKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIRADTKNSQ 91
Query: 374 VTLIHLDLSSFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFATNHMGH 553
V + LDLS KSI+AF F A L+ILINNAGVM CPY + DG E F NH+GH
Sbjct: 92 VLVRKLDLSDTKSIRAFAERFLAEEKKLHILINNAGVMMCPYSKTTDGFETHFGVNHLGH 151
Query: 554 FLLTNLLLDTMKNTAKTSGVEGRILNLSSIAHI 652
FLLT LLL+ +K +A R++NLSSIAH+
Sbjct: 152 FLLTYLLLERLKESA-----PARVVNLSSIAHL 179
>sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 OS=Bos taurus GN=RDH12 PE=2
SV=1
Length = 316
Score = 128 bits (320), Expect = 1e-028
Identities = 70/141 (49%), Positives = 89/141 (63%), Gaps = 5/141 (3%)
Frame = +2
Query: 227 IITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLIHLDLSSF 406
+ITG GIG ETA +A+RGA V I R++ E A +EI N++V + LDLS
Sbjct: 43 VITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIQADTKNSQVLVRKLDLSDT 102
Query: 407 KSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFATNHMGHFLLTNLLLDTM 586
KSI+AF F A L+ILINNAGVM CPY + DG E A NH+GHFLLT+LLL +
Sbjct: 103 KSIRAFAEGFLAEEKQLHILINNAGVMLCPYSKTADGFETHLAVNHLGHFLLTHLLLGRL 162
Query: 587 KNTAKTSGVEGRILNLSSIAH 649
K +A R++NLSS+AH
Sbjct: 163 KESA-----PARVVNLSSVAH 178
>sp|Q8TC12|RDH11_HUMAN Retinol dehydrogenase 11 OS=Homo sapiens GN=RDH11 PE=1
SV=2
Length = 318
Score = 125 bits (313), Expect = 8e-028
Identities = 66/141 (46%), Positives = 89/141 (63%), Gaps = 5/141 (3%)
Frame = +2
Query: 227 IITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLIHLDLSSF 406
++TG GIG ETA +AQRGA V + R++ E EI N +V + LDLS
Sbjct: 45 VVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDT 104
Query: 407 KSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFATNHMGHFLLTNLLLDTM 586
KSI+AF + F A L++LINNAGVM CPY + DG E+ NH+GHFLLT+LLL+ +
Sbjct: 105 KSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKL 164
Query: 587 KNTAKTSGVEGRILNLSSIAH 649
K +A + RI+N+SS+AH
Sbjct: 165 KESAPS-----RIVNVSSLAH 180
>sp|Q03326|OXIR_STRAT Probable oxidoreductase OS=Streptomyces antibioticus PE=3
SV=1
Length = 298
Score = 123 bits (307), Expect = 4e-027
Identities = 97/276 (35%), Positives = 137/276 (49%), Gaps = 28/276 (10%)
Frame = +2
Query: 203 IDATHLTAIITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTL 382
+D T A++TGG G+G ET +A GA V + R AE E+ RVT
Sbjct: 1 MDLTGRRAVVTGGASGLGAETVRALAAAGAEVTVATRRPLSAEPLVQELAAAGGAGRVTA 60
Query: 383 IHLDLSSFKSIKAFVRDFHALHLPLNILINNAGVMFCPYQ-LSEDGIELQFATNHMGHFL 559
LDLS S+++F R + PL+IL+ NAG+M P + L+ +G E+Q ATN++GHF
Sbjct: 61 EALDLSDPASVESFARAWRG---PLDILVANAGIMALPTRTLAPNGWEMQLATNYLGHFA 117
Query: 560 LTNLLLDTMKNTAKTSGVEGRILNLSSIAHIYTYQEGIQFDSINDI-CSYSDKRAYGQSK 736
L L +++ RI+ +SS AH+ F+ + Y AYGQSK
Sbjct: 118 LATGLHAALRDAG-----SARIVVVSSGAHL---DAPFDFEDAHFARRPYDPWVAYGQSK 169
Query: 737 LANILHANKLSRQLQEEGVNITVNSVHPGLILTNLFQHT--ALLMRF--------LKFFS 886
A++L R + ITVN+++PG ILT L +H + F +K
Sbjct: 170 AADVLFTVGARRWAAD---GITVNALNPGYILTRLQRHVDDETMRAFGVMDDQGNVKPLP 226
Query: 887 FYLWKNIPQGAATTCYVALHPSLKEVTGEYFADCNE 994
+Y K QGAAT+ +A P LK VTG YF D E
Sbjct: 227 YY--KTPEQGAATSVLLAASPLLKGVTGRYFEDNQE 260
>sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 OS=Homo sapiens GN=RDH12 PE=1
SV=3
Length = 316
Score = 123 bits (307), Expect = 4e-027
Identities = 68/141 (48%), Positives = 87/141 (61%), Gaps = 5/141 (3%)
Frame = +2
Query: 227 IITGGTGGIGMETAGVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLIHLDLSSF 406
+ITG GIG ETA +A RGA V I R++ E A +EI N++V + LDLS
Sbjct: 43 VITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDT 102
Query: 407 KSIKAFVRDFHALHLPLNILINNAGVMFCPYQLSEDGIELQFATNHMGHFLLTNLLLDTM 586
KSI+AF F A L+ILINNAGVM CPY + DG E NH+GHFLLT LLL+ +
Sbjct: 103 KSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERL 162
Query: 587 KNTAKTSGVEGRILNLSSIAH 649
K +A R++N+SS+AH
Sbjct: 163 KVSA-----PARVVNVSSVAH 178
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,727,594,170
Number of Sequences: 518415
Number of Extensions: 61727594170
Number of Successful Extensions: 397900902
Number of sequences better than 0.0: 0
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