BLASTX 7.6.2
Query= UN15224 /QuerySize=998
(997 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabi... 184 8e-046
sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase D... 183 2e-045
sp|Q55A09|Y9963_DICDI Probable serine/threonine-protein kinase D... 173 3e-042
sp|Q54TA1|DRKC_DICDI Probable serine/threonine-protein kinase dr... 158 1e-037
sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kin... 140 2e-032
sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kin... 140 2e-032
sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kina... 135 7e-031
sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase ki... 134 1e-030
sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase ki... 134 1e-030
sp|A7J1T0|M313B_XENLA Mitogen-activated protein kinase kinase ki... 133 2e-030
sp|O43283|M3K13_HUMAN Mitogen-activated protein kinase kinase ki... 131 1e-029
sp|Q1HKZ5|M3K13_MOUSE Mitogen-activated protein kinase kinase ki... 131 1e-029
sp|Q5R8X7|M3K13_PONAB Mitogen-activated protein kinase kinase ki... 130 2e-029
sp|A7J1T2|M313A_XENLA Mitogen-activated protein kinase kinase ki... 129 3e-029
sp|A7MBB4|M3K13_BOVIN Mitogen-activated protein kinase kinase ki... 128 8e-029
sp|Q54RZ7|Y1199_DICDI Probable serine/threonine-protein kinase D... 117 1e-025
sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase ki... 106 3e-022
sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase ki... 106 3e-022
sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kina... 106 3e-022
sp|Q95UN8|M3KSL_DROME Mitogen-activated protein kinase kinase ki... 105 8e-022
>sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabidopsis thaliana
GN=HT1 PE=1 SV=1
Length = 390
Score = 184 bits (467), Expect = 8e-046
Identities = 87/192 (45%), Positives = 128/192 (66%), Gaps = 1/192 (0%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKGV-FKLPALLKVAIDICKGMNYLHQNNIIHRDLKAAN 276
P CI+TE+M G++ YL+K++ + +L++A+DI +GM YLH +IHRDLK+ N
Sbjct: 158 PVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQGVIHRDLKSNN 217
Query: 277 LLMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLW 456
LL+++ VKVADFG + ++ Q GTYRWMAPE+I+ KPY K DV+S+GIVLW
Sbjct: 218 LLLNDEMRVKVADFGTSCLETQCREAKGNMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLW 277
Query: 457 ELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEII 636
EL T +P++ MTP+QAA V +K RP +P P + L++R W ++P+ RPDFS I+
Sbjct: 278 ELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLIKRCWSENPSKRPDFSNIV 337
Query: 637 EQLQEIAKEVDE 672
L++ + V E
Sbjct: 338 AVLEKYDECVKE 349
>sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase DDB_G0267514
OS=Dictyostelium discoideum GN=DDB_G0267514 PE=3 SV=1
Length = 916
Score = 183 bits (463), Expect = 2e-045
Identities = 83/185 (44%), Positives = 125/185 (67%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNYLHQNNIIHRDLKAANL 279
P+LC +TE++PGGS+YD LH +K + K+AI I +GMNYLH + +IHRD+K+ NL
Sbjct: 731 PNLCFITEYLPGGSLYDALHSKKIKMNMQLYKKLAIQIAQGMNYLHLSGVIHRDIKSLNL 790
Query: 280 LMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLWE 459
L+DEH VK+ DFG++ +K+++ MT G+ WM+PE++ + Y K DV+++GI+LWE
Sbjct: 791 LLDEHMNVKICDFGLSKLKSKSTEMTKSIGSPIWMSPELLMGEDYTEKVDVYAFGIILWE 850
Query: 460 LLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEIIE 639
L TG++PY + +Q A+ V K LRP IP ++ L++ W +DP RP F+EI+
Sbjct: 851 LGTGELPYSGLDSVQLALAVTTKSLRPPIPNAWPYQLSHLIQACWHQDPLKRPSFTEILN 910
Query: 640 QLQEI 654
L EI
Sbjct: 911 LLNEI 915
>sp|Q55A09|Y9963_DICDI Probable serine/threonine-protein kinase DDB_G0272254
OS=Dictyostelium discoideum GN=DDB_G0272254 PE=3 SV=1
Length = 1331
Score = 173 bits (436), Expect = 3e-042
Identities = 85/186 (45%), Positives = 122/186 (65%), Gaps = 7/186 (3%)
Frame = +1
Query: 106 LCIVTEFMPGGSVYDYLH----KQKGVFKLPA--LLKVAIDICKGMNYLHQNNIIHRDLK 267
+CIV EF+P G++++ +H +Q+ KL + +L +A DI +GM +LH NIIHRDLK
Sbjct: 1143 MCIVMEFLPSGNLFELIHSKPSEQQQSIKLDSTLILAIAFDIARGMQHLHTRNIIHRDLK 1202
Query: 268 AANLLMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGI 447
++NLLMD+H +K+AD G+A + T MT GT W APE++ H+ Y+ KADV+SY I
Sbjct: 1203 SSNLLMDKHFNIKIADLGIARETSFTQTMTT-IGTVAWTAPEILRHESYNQKADVYSYAI 1261
Query: 448 VLWELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFS 627
VL+ELLTG+ PY+ + P+ A + V KGLRP +P P ++L+ W +DP RP F
Sbjct: 1262 VLYELLTGEEPYQGIPPMNAGILVASKGLRPELPDNCDPNWKKLVVWCWSEDPNKRPSFE 1321
Query: 628 EIIEQL 645
EI L
Sbjct: 1322 EITNYL 1327
>sp|Q54TA1|DRKC_DICDI Probable serine/threonine-protein kinase drkC
OS=Dictyostelium discoideum GN=drkC PE=3 SV=1
Length = 749
Score = 158 bits (397), Expect = 1e-037
Identities = 84/188 (44%), Positives = 113/188 (60%), Gaps = 5/188 (2%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNYLH--QNNIIHRDLKAA 273
P + IV E+MP GS+Y LH P + +A+DI KGMNYLH +IHRDLK+
Sbjct: 560 PEILIVMEYMPLGSLYRILHDPSISLDWPRMKSMALDIAKGMNYLHCCDPIVIHRDLKSH 619
Query: 274 NLLMDEHEVVKVADFGVAI-VKAQTGVMTAET--GTYRWMAPEVIEHKPYDHKADVFSYG 444
NLL+DEH VK++DFG++ K TA T GT W APEV+ + PY KADVFS+
Sbjct: 620 NLLVDEHYRVKISDFGLSTRFKKHLDKKTAMTPVGTPCWTAPEVLRNDPYTEKADVFSFA 679
Query: 445 IVLWELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDF 624
IVLWE++T + PY+ M Q + V Q LRP +P + L+ W +DP RP F
Sbjct: 680 IVLWEIVTREDPYQGMPTFQIVISVGQHKLRPIVPPQVSAPFTRLITECWSEDPQQRPSF 739
Query: 625 SEIIEQLQ 648
EI+++L+
Sbjct: 740 QEIVKRLE 747
>sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kinase MLT OS=Mus
musculus GN=Mltk PE=1 SV=1
Length = 802
Score = 140 bits (352), Expect = 2e-032
Identities = 74/194 (38%), Positives = 113/194 (58%), Gaps = 5/194 (2%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKG-VFKLPALLKVAIDICKGMNYLHQN---NIIHRDLK 267
P+ IVTE+ GS+YDY++ + + ++ A D+ KGM+YLH +IHRDLK
Sbjct: 76 PNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLK 135
Query: 268 AANLLMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGI 447
+ N+++ V+K+ DFG + T M+ GT+ WMAPEVI+ P D +SYG+
Sbjct: 136 SRNVVIAADGVLKICDFGASRFHNHTTHMSL-VGTFPWMAPEVIQSLPVSETCDTYSYGV 194
Query: 448 VLWELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFS 627
VLWE+LT ++P++ + LQ A VV+K R TIP EL+ + WE D RP F
Sbjct: 195 VLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFK 254
Query: 628 EIIEQLQEIAKEVD 669
+II L+ ++ + +
Sbjct: 255 QIISILESMSNDTN 268
>sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kinase MLT OS=Homo
sapiens GN=MLTK PE=1 SV=2
Length = 800
Score = 140 bits (351), Expect = 2e-032
Identities = 74/192 (38%), Positives = 112/192 (58%), Gaps = 5/192 (2%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKG-VFKLPALLKVAIDICKGMNYLHQN---NIIHRDLK 267
P+ IVTE+ GS+YDY++ + + ++ A D+ KGM+YLH +IHRDLK
Sbjct: 76 PNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLK 135
Query: 268 AANLLMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGI 447
+ N+++ V+K+ DFG + T M+ GT+ WMAPEVI+ P D +SYG+
Sbjct: 136 SRNVVIAADGVLKICDFGASRFHNHTTHMSL-VGTFPWMAPEVIQSLPVSETCDTYSYGV 194
Query: 448 VLWELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFS 627
VLWE+LT ++P++ + LQ A VV+K R TIP EL+ + WE D RP F
Sbjct: 195 VLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFK 254
Query: 628 EIIEQLQEIAKE 663
+II L+ ++ +
Sbjct: 255 QIISILESMSND 266
>sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kinase 12 OS=Rattus
norvegicus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 135 bits (338), Expect = 7e-031
Identities = 73/196 (37%), Positives = 109/196 (55%), Gaps = 3/196 (1%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKGVFKLPALL-KVAIDICKGMNYLHQNNIIHRDLKAAN 276
P CI+ EF G +Y+ L + V P+LL ++ I GMNYLH + IIHRDLK+ N
Sbjct: 217 PCYCILMEFCAQGQLYEVLRAGRPV--TPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPN 274
Query: 277 LLMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLW 456
+L+ +VVK++DFG + + + GT WMAPEVI ++P K D++S+G+VLW
Sbjct: 275 MLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLW 334
Query: 457 ELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEII 636
ELLTG+IPY+ + GV L +P + L+ + W + P RP F +I+
Sbjct: 335 ELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRKPRNRPSFRQIL 394
Query: 637 EQLQEIAKEVDEEEEE 684
L + +V +E
Sbjct: 395 LHLDIASADVLSTPQE 410
>sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 OS=Homo
sapiens GN=MAP3K12 PE=1 SV=2
Length = 859
Score = 134 bits (336), Expect = 1e-030
Identities = 73/196 (37%), Positives = 108/196 (55%), Gaps = 3/196 (1%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKGVFKLPALL-KVAIDICKGMNYLHQNNIIHRDLKAAN 276
P CI+ EF G +Y+ L + V P+LL ++ I GMNYLH + IIHRDLK+ N
Sbjct: 184 PCYCILMEFCAQGQLYEVLRAGRPV--TPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPN 241
Query: 277 LLMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLW 456
+L+ +VVK++DFG + + + GT WMAPEVI ++P K D++S+G+VLW
Sbjct: 242 MLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLW 301
Query: 457 ELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEII 636
ELLTG+IPY+ + GV L +P + L+ + W P RP F +I+
Sbjct: 302 ELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQIL 361
Query: 637 EQLQEIAKEVDEEEEE 684
L + +V +E
Sbjct: 362 LHLDIASADVLSTPQE 377
>sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase kinase 12 OS=Mus
musculus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 134 bits (336), Expect = 1e-030
Identities = 73/196 (37%), Positives = 108/196 (55%), Gaps = 3/196 (1%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKGVFKLPALL-KVAIDICKGMNYLHQNNIIHRDLKAAN 276
P CI+ EF G +Y+ L + V P+LL ++ I GMNYLH + IIHRDLK+ N
Sbjct: 217 PCYCILMEFCAQGQLYEVLRAGRPV--TPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPN 274
Query: 277 LLMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLW 456
+L+ +VVK++DFG + + + GT WMAPEVI ++P K D++S+G+VLW
Sbjct: 275 MLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLW 334
Query: 457 ELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEII 636
ELLTG+IPY+ + GV L +P + L+ + W P RP F +I+
Sbjct: 335 ELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQIL 394
Query: 637 EQLQEIAKEVDEEEEE 684
L + +V +E
Sbjct: 395 LHLDIASADVLSTPQE 410
>sp|A7J1T0|M313B_XENLA Mitogen-activated protein kinase kinase kinase 13-B
OS=Xenopus laevis GN=map3k13-b PE=2 SV=1
Length = 961
Score = 133 bits (334), Expect = 2e-030
Identities = 69/189 (36%), Positives = 105/189 (55%), Gaps = 1/189 (0%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNYLHQNNIIHRDLKAANL 279
P CI+ E+ G +Y+ L + V L++ + I GMNYLH + IIHRDLK+ N+
Sbjct: 230 PCYCILMEYCAQGQLYEVLRAGRKVTP-KLLVEWSTGIASGMNYLHLHKIIHRDLKSPNV 288
Query: 280 LMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLWE 459
L+ + VK++DFG + + + GT WMAPEVI ++P K D++S+G++LWE
Sbjct: 289 LVTHADTVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVLLWE 348
Query: 460 LLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEIIE 639
LLTG+IPY+ + GV L +P + LM++ W+ P RP F +I+
Sbjct: 349 LLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQILM 408
Query: 640 QLQEIAKEV 666
L A +V
Sbjct: 409 HLDIAAADV 417
>sp|O43283|M3K13_HUMAN Mitogen-activated protein kinase kinase kinase 13 OS=Homo
sapiens GN=MAP3K13 PE=1 SV=1
Length = 966
Score = 131 bits (328), Expect = 1e-029
Identities = 69/190 (36%), Positives = 104/190 (54%), Gaps = 3/190 (1%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKGVFKLPALL-KVAIDICKGMNYLHQNNIIHRDLKAAN 276
P CI+ E+ G +Y+ L + + P LL + I GMNYLH + IIHRDLK+ N
Sbjct: 227 PCYCIIMEYCAHGQLYEVLRAGRKI--TPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPN 284
Query: 277 LLMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLW 456
+L+ + VK++DFG + + + GT WMAPEVI ++P K D++S+G+VLW
Sbjct: 285 VLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLW 344
Query: 457 ELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEII 636
ELLTG+IPY+ + GV L +P + LM++ W+ P RP F + +
Sbjct: 345 ELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTL 404
Query: 637 EQLQEIAKEV 666
L + +V
Sbjct: 405 MHLDIASADV 414
>sp|Q1HKZ5|M3K13_MOUSE Mitogen-activated protein kinase kinase kinase 13 OS=Mus
musculus GN=Map3k13 PE=2 SV=1
Length = 959
Score = 131 bits (328), Expect = 1e-029
Identities = 69/190 (36%), Positives = 104/190 (54%), Gaps = 3/190 (1%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKGVFKLPALL-KVAIDICKGMNYLHQNNIIHRDLKAAN 276
P CI+ E+ G +Y+ L + + P LL + I GMNYLH + IIHRDLK+ N
Sbjct: 226 PCYCIIMEYCAHGQLYEVLRAGRKI--TPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPN 283
Query: 277 LLMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLW 456
+L+ + VK++DFG + + + GT WMAPEVI ++P K D++S+G+VLW
Sbjct: 284 VLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLW 343
Query: 457 ELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEII 636
ELLTG+IPY+ + GV L +P + LM++ W+ P RP F + +
Sbjct: 344 ELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTL 403
Query: 637 EQLQEIAKEV 666
L + +V
Sbjct: 404 MHLDIASADV 413
>sp|Q5R8X7|M3K13_PONAB Mitogen-activated protein kinase kinase kinase 13
OS=Pongo abelii GN=MAP3K13 PE=2 SV=1
Length = 966
Score = 130 bits (325), Expect = 2e-029
Identities = 68/190 (35%), Positives = 104/190 (54%), Gaps = 3/190 (1%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKGVFKLPALL-KVAIDICKGMNYLHQNNIIHRDLKAAN 276
P CI+ E+ G +Y+ L + + P LL + I GMNYLH + IIHRDLK+ N
Sbjct: 227 PCYCIIMEYCAHGQLYEVLRAGRKI--TPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPN 284
Query: 277 LLMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLW 456
+L+ + VK++DFG + + + GT W+APEVI ++P K D++S+G+VLW
Sbjct: 285 VLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWLAPEVIRNEPVSEKVDIWSFGVVLW 344
Query: 457 ELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEII 636
ELLTG+IPY+ + GV L +P + LM++ W+ P RP F + +
Sbjct: 345 ELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTL 404
Query: 637 EQLQEIAKEV 666
L + +V
Sbjct: 405 MHLDIASADV 414
>sp|A7J1T2|M313A_XENLA Mitogen-activated protein kinase kinase kinase 13-A
OS=Xenopus laevis GN=map3k13-a PE=2 SV=1
Length = 961
Score = 129 bits (324), Expect = 3e-029
Identities = 67/189 (35%), Positives = 103/189 (54%), Gaps = 1/189 (0%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNYLHQNNIIHRDLKAANL 279
P C++ E+ G +Y+ L + V L+ + I GMNYLH + IIHRDLK+ N+
Sbjct: 228 PCYCLIMEYCAHGQLYEVLRAGRKV-SPRLLVDWSNGIASGMNYLHLHKIIHRDLKSPNV 286
Query: 280 LMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLWE 459
L+ + VK++DFG + + + GT WMAPEVI ++P K D++S+G++LWE
Sbjct: 287 LVTHTDTVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVLLWE 346
Query: 460 LLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEIIE 639
LLTG+IPY+ + GV L +P + LM++ W P RP F +I+
Sbjct: 347 LLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWHSKPRNRPSFRQILM 406
Query: 640 QLQEIAKEV 666
L + +V
Sbjct: 407 HLDIASADV 415
>sp|A7MBB4|M3K13_BOVIN Mitogen-activated protein kinase kinase kinase 13 OS=Bos
taurus GN=MAP3K13 PE=2 SV=1
Length = 966
Score = 128 bits (320), Expect = 8e-029
Identities = 68/190 (35%), Positives = 103/190 (54%), Gaps = 3/190 (1%)
Frame = +1
Query: 100 PHLCIVTEFMPGGSVYDYLHKQKGVFKLPALL-KVAIDICKGMNYLHQNNIIHRDLKAAN 276
P CI+ E+ G +Y+ L + + P LL + I GMNYLH + IIHRDLK+ N
Sbjct: 227 PCYCIIMEYCAHGQLYEVLRAGRKI--TPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPN 284
Query: 277 LLMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLW 456
+L+ + VK++DFG + + + GT WMAPEVI ++P K D++S+G+VLW
Sbjct: 285 VLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLW 344
Query: 457 ELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEII 636
ELLTG+IPY+ + GV L +P + LM++ W+ RP F + +
Sbjct: 345 ELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKTRNRPSFRQTL 404
Query: 637 EQLQEIAKEV 666
L + +V
Sbjct: 405 MHLDIASADV 414
>sp|Q54RZ7|Y1199_DICDI Probable serine/threonine-protein kinase DDB_G0282895
OS=Dictyostelium discoideum GN=DDB_G0282895 PE=3 SV=1
Length = 1634
Score = 117 bits (293), Expect = 1e-025
Identities = 65/179 (36%), Positives = 106/179 (59%), Gaps = 2/179 (1%)
Frame = +1
Query: 112 IVTEFMPGGSVYDYLHKQKGVFKLPALLKVAIDICKGMNYLHQNNIIHRDLKAANLLMDE 291
IVTE M G++ + ++K K + L ++K A+ + +G+ YLH + IHRD+KAAN+L+D+
Sbjct: 1452 IVTELMHKGTLLEVINKNKPL-SLEDIIKYALSVAQGLAYLHSVDFIHRDIKAANILVDK 1510
Query: 292 HEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLWELLTG 471
+ KV DFG++ V MTA GT +W +PE + + Y +DV+SYG++L+EL TG
Sbjct: 1511 NNNAKVGDFGLSRVIDNNFNMTAVAGTPKWESPECLMGEAYTSASDVYSYGMMLFELATG 1570
Query: 472 KIPY-EYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEIIEQL 645
P+ E + ++ A V K L+P I + L++ P RP ++II++L
Sbjct: 1571 DEPFLEIQSIVELARSVCDKKLKPKISSSVPNFISSLIKDCLHNSPKKRPTMNQIIQKL 1629
>sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 OS=Homo
sapiens GN=MAP3K11 PE=1 SV=1
Length = 847
Score = 106 bits (263), Expect = 3e-022
Identities = 54/129 (41%), Positives = 78/129 (60%), Gaps = 1/129 (0%)
Frame = +1
Query: 289 EHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLWELLT 468
EH+ +K+ DFG+A +T M+A GTY WMAPEVI+ + +DV+S+G++LWELLT
Sbjct: 259 EHKTLKITDFGLAREWHKTTQMSA-AGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLT 317
Query: 469 GKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEIIEQLQ 648
G++PY + L A GV L IP +LM W +DP RPDF+ I++QL+
Sbjct: 318 GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLE 377
Query: 649 EIAKEVDEE 675
+ +V E
Sbjct: 378 ALEAQVLRE 386
>sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase kinase 11 OS=Mus
musculus GN=Map3k11 PE=1 SV=1
Length = 850
Score = 106 bits (263), Expect = 3e-022
Identities = 54/129 (41%), Positives = 78/129 (60%), Gaps = 1/129 (0%)
Frame = +1
Query: 289 EHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLWELLT 468
EH+ +K+ DFG+A +T M+A GTY WMAPEVI+ + +DV+S+G++LWELLT
Sbjct: 260 EHKTLKITDFGLAREWHKTTQMSA-AGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLT 318
Query: 469 GKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEIIEQLQ 648
G++PY + L A GV L IP +LM W +DP RPDF+ I++QL+
Sbjct: 319 GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLE 378
Query: 649 EIAKEVDEE 675
+ +V E
Sbjct: 379 ALEAQVLRE 387
>sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kinase 11 OS=Rattus
norvegicus GN=Map3k11 PE=2 SV=1
Length = 850
Score = 106 bits (263), Expect = 3e-022
Identities = 54/129 (41%), Positives = 78/129 (60%), Gaps = 1/129 (0%)
Frame = +1
Query: 289 EHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDHKADVFSYGIVLWELLT 468
EH+ +K+ DFG+A +T M+A GTY WMAPEVI+ + +DV+S+G++LWELLT
Sbjct: 260 EHKTLKITDFGLAREWHKTTQMSA-AGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLT 318
Query: 469 GKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEKDPTLRPDFSEIIEQLQ 648
G++PY + L A GV L IP +LM W +DP RPDF+ I++QL+
Sbjct: 319 GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLE 378
Query: 649 EIAKEVDEE 675
+ +V E
Sbjct: 379 ALEAQVLRE 387
>sp|Q95UN8|M3KSL_DROME Mitogen-activated protein kinase kinase kinase
OS=Drosophila melanogaster GN=slpr PE=1 SV=1
Length = 1161
Score = 105 bits (260), Expect = 8e-022
Identities = 57/139 (41%), Positives = 80/139 (57%), Gaps = 4/139 (2%)
Frame = +1
Query: 241 NNIIHRDLKAANLLMDEHEVVKVADFGVAIVKAQTGVMTAETGTYRWMAPEVIEHKPYDH 420
N +I+ ++ +L + + +K+ DFG+A T M+A GTY WM PEVI Y
Sbjct: 269 NVLIYEAIEGNHL---QQKTLKITDFGLAREMYNTQRMSA-AGTYAWMPPEVISVSTYSK 324
Query: 421 KADVFSYGIVLWELLTGKIPYEYMTPLQAAVGVVQKGLRPTIPKKTHPKMRELMERLWEK 600
+DV+SYG++LWEL+TG+ PY+ PL A GV L IPK LM+ W+
Sbjct: 325 FSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQT 384
Query: 601 DPTLRPDFSEIIEQLQEIA 657
DP RP F EI++QL+ IA
Sbjct: 385 DPHKRPGFKEILKQLESIA 403
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,727,594,170
Number of Sequences: 518415
Number of Extensions: 61727594170
Number of Successful Extensions: 397900902
Number of sequences better than 0.0: 0
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