BLASTX 7.6.2
Query= UN15996 /QuerySize=1625
(1624 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54TM7|DRKD_DICDI Probable serine/threonine-protein kinase dr... 155 9e-037
sp|Q7T6X2|YR826_MIMIV Putative serine/threonine-protein kinase/r... 130 4e-029
sp|Q15569|TESK1_HUMAN Dual specificity testis-specific protein k... 121 2e-026
sp|Q63572|TESK1_RAT Dual specificity testis-specific protein kin... 120 3e-026
sp|P54739|PKAA_STRCO Serine/threonine-protein kinase pkaA OS=Str... 119 6e-026
sp|O70146|TESK1_MOUSE Dual specificity testis-specific protein k... 118 2e-025
sp|Q86AE1|Y9853_DICDI Probable serine/threonine-protein kinase D... 114 2e-024
sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinase kin... 109 6e-023
sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinase kin... 108 1e-022
sp|Q13233|M3K1_HUMAN Mitogen-activated protein kinase kinase kin... 106 7e-022
sp|P53349|M3K1_MOUSE Mitogen-activated protein kinase kinase kin... 106 9e-022
sp|Q9HFW2|CLA4_ASHGO Serine/threonine-protein kinase CLA4 OS=Ash... 104 2e-021
sp|Q62925|M3K1_RAT Mitogen-activated protein kinase kinase kinas... 104 3e-021
sp|Q54XY6|Y0019_DICDI Probable serine/threonine-protein kinase D... 103 4e-021
sp|P48562|CLA4_YEAST Serine/threonine-protein kinase CLA4 OS=Sac... 101 3e-020
sp|O14427|CLA4_CANAL Serine/threonine-protein kinase CLA4 OS=Can... 99 8e-020
sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase D... 94 3e-018
sp|O22040|ANP1_ARATH Mitogen-activated protein kinase kinase kin... 93 6e-018
sp|Q96S53|TESK2_HUMAN Dual specificity testis-specific protein k... 92 7e-018
sp|O64629|AUR3_ARATH Serine/threonine-protein kinase Aurora-3 OS... 84 3e-015
>sp|Q54TM7|DRKD_DICDI Probable serine/threonine-protein kinase drkD
OS=Dictyostelium discoideum GN=drkD PE=2 SV=1
Length = 1288
Score = 155 bits (391), Expect = 9e-037
Identities = 98/239 (41%), Positives = 134/239 (56%), Gaps = 13/239 (5%)
Frame = +3
Query: 651 WRGTPVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLITEYL 830
WRGT VAVK + + +L I D R EVDLL KLRHPNIV F+GA TE ++TEYL
Sbjct: 870 WRGTEVAVKMLFNDNVNLKL-ISDLRKEVDLLCKLRHPNIVLFMGACTEPSSPCIVTEYL 928
Query: 831 RGGDLHQYLKEKG-GLTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSSAD 1007
G L L ++ + + D ARGMTYLH+ +IIHRDLK N+L+ +S
Sbjct: 929 SRGSLANILLDESIEMDWGLRLQLGFDCARGMTYLHSRNPIIIHRDLKTDNLLVDDSW-- 986
Query: 1008 HLKVGDFGLSKLIKVQNSHDVYK-MTGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILYE 1184
+KV DFGL+ + SH K M G TG ++APEV Y +K DV+S+A++L+E
Sbjct: 987 QVKVADFGLATV----KSHTFAKTMCGTTG---WVAPEVLAEEGYTEKADVYSYAIVLWE 1039
Query: 1185 MLEGEPPFANYEPYEAAKHVSDGHRPTFRSKGCTPDLRELIVKCWDADMNQRPSFLDIL 1361
+L P+A + + + G R + C P L+ +CW+ D RPSF +IL
Sbjct: 1040 LLTRLIPYAGKNTMQVVRSIDRGERLPMPA-WCPPKYAALMNRCWETDPTHRPSFPEIL 1097
>sp|Q7T6X2|YR826_MIMIV Putative serine/threonine-protein kinase/receptor R826
OS=Acanthamoeba polyphaga mimivirus GN=MIMI_R826 PE=4 SV=2
Length = 1657
Score = 130 bits (325), Expect = 4e-029
Identities = 88/261 (33%), Positives = 138/261 (52%), Gaps = 29/261 (11%)
Frame = +3
Query: 642 KAYWRGTPVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLIT 821
K WRGT VAVK I P + + + ++F+ EV ++ LRHPN+V F+ A T+ + ++
Sbjct: 802 KGTWRGTEVAVKMISPDKTITKDIERNFKDEVRVMTTLRHPNVVLFMAASTKPPKMCIVM 861
Query: 822 EYLRGGDLHQYLKEKGGLTP----ATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLL 989
E++ G LH LK + L P A V A ++GM +LH+ + I HRDLK N+LL
Sbjct: 862 EFMALGSLHDLLKNE--LIPDIPFALKVKIAYQASKGMHFLHS--SGITHRDLKSLNLLL 917
Query: 990 VNSSADHLKVGDFGLSKLIKVQNSHDVYKMTGE--TGSYRYMAPEVFKHRKYDKKV---- 1151
++KV DFGL+K DV + E G+ ++ APE+ D++V
Sbjct: 918 --DIKWNVKVSDFGLTKF-----KSDVKSINPEKFAGTIQWTAPEILSE---DREVDYIL 967
Query: 1152 -DVFSFAMILYEMLEGEPPFANYEPYE-AAKHVSDGHRPTFRSK---GCTPDLRELIVKC 1316
DV+SF +I++E++ + P+ P A + D +RP + P+ EL+ C
Sbjct: 968 SDVYSFGIIMWELITRDQPYFGMSPAAIAVSVIRDNYRPVISDQLRSEVAPEYIELLTSC 1027
Query: 1317 WDADMNQRPSFLDILKRLDKI 1379
W D RP+FL+I+ RL +
Sbjct: 1028 WHFDPTIRPTFLEIMTRLSNL 1048
>sp|Q15569|TESK1_HUMAN Dual specificity testis-specific protein kinase 1 OS=Homo
sapiens GN=TESK1 PE=1 SV=2
Length = 626
Score = 121 bits (302), Expect = 2e-026
Identities = 76/222 (34%), Positives = 113/222 (50%), Gaps = 3/222 (1%)
Frame = +3
Query: 732 EVDLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHQYLKEKGGLTPATAVNFALDI 911
EV L+ +LRHPNI++F+G + L +TEY+ GG L Q L L+ ++ ALDI
Sbjct: 100 EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDI 159
Query: 912 ARGMTYLHNEPNVIIHRDLKPRNVLLVNSSADHLK-VGDFGLSKLIKVQNSHDVYKMTGE 1088
ARG+ YLH++ + HRDL +N L+ VGDFGL++ I V +
Sbjct: 160 ARGLRYLHSKG--VFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAV 217
Query: 1089 TGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPPFANYEPYEAAKHVSDGHRPTF 1268
GS +MAPEV + YD+K DVF+F ++L E++ P +Y P + T
Sbjct: 218 VGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTL 277
Query: 1269 RSKGCTPDLRELIVKCWDADMNQRPSFLDILKRLDKIKETLP 1394
C L + C + + + R F +I + L+ I E LP
Sbjct: 278 VGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLP 319
>sp|Q63572|TESK1_RAT Dual specificity testis-specific protein kinase 1 OS=Rattus
norvegicus GN=Tesk1 PE=1 SV=1
Length = 628
Score = 120 bits (300), Expect = 3e-026
Identities = 75/222 (33%), Positives = 112/222 (50%), Gaps = 3/222 (1%)
Frame = +3
Query: 732 EVDLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHQYLKEKGGLTPATAVNFALDI 911
EV L+ +LRHPNI++F+G + L +TEY+ GG L Q L L+ ++ ALDI
Sbjct: 95 EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDI 154
Query: 912 ARGMTYLHNEPNVIIHRDLKPRNVLLVNSSADHLK-VGDFGLSKLIKVQNSHDVYKMTGE 1088
A+G+ YLH + + HRDL +N L+ VGDFGL++ I V +
Sbjct: 155 AQGLRYLHAKG--VFHRDLTSKNCLVRREDGGFTAVVGDFGLAEKIPVYREGARKEPLAV 212
Query: 1089 TGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPPFANYEPYEAAKHVSDGHRPTF 1268
GS +MAPEV + YD+K DVF+F ++L E++ P +Y P + T
Sbjct: 213 VGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTL 272
Query: 1269 RSKGCTPDLRELIVKCWDADMNQRPSFLDILKRLDKIKETLP 1394
C L + C + + R F +I + L++I E LP
Sbjct: 273 VGNDCPLPFLLLAIHCCSMEPSARAPFTEITQHLEQILEQLP 314
>sp|P54739|PKAA_STRCO Serine/threonine-protein kinase pkaA OS=Streptomyces
coelicolor GN=pkaA PE=3 SV=1
Length = 543
Score = 119 bits (298), Expect = 6e-026
Identities = 81/247 (32%), Positives = 129/247 (52%), Gaps = 14/247 (5%)
Frame = +3
Query: 657 GTPVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLITEYLRG 836
G VA+K + L+ D ++ F E +L++L HPNIV+ V E + L L+ + + G
Sbjct: 42 GETVAIKVLKEELASDADIVMRFLRERSVLLRLTHPNIVRVRDLVVEGELLALVMDLIDG 101
Query: 837 GDLHQYLKEKGGLTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSSAD-HL 1013
DLH+YL+E G LTP A IA + H + ++HRDLKP NVLL + + H
Sbjct: 102 PDLHRYLRENGPLTPVAAALLTAQIADALAASHADG--VVHRDLKPANVLLKQTGGEMHP 159
Query: 1014 KVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLE 1193
+ DFG+++L +S + + G+ Y+APE + R VDV+ ++LYE++
Sbjct: 160 MLTDFGIARL---ADSPGLTRTHEFVGTPAYVAPESAEGRPQTSAVDVYGAGILLYELVT 216
Query: 1194 GEPPFANYEPYEAA-KHVS-DGHRPTFRSKGCTPD-LRELIVKCWDADMNQRPSFLDILK 1364
G PPF E +H+S + RP+ PD L +I +C + + RPS ++ +
Sbjct: 217 GRPPFGGGSALEVLHQHLSAEPRRPS-----TVPDPLWTVIERCLRKNPDDRPSAENLAR 271
Query: 1365 RLDKIKE 1385
L + E
Sbjct: 272 GLRVVAE 278
>sp|O70146|TESK1_MOUSE Dual specificity testis-specific protein kinase 1 OS=Mus
musculus GN=Tesk1 PE=2 SV=3
Length = 627
Score = 118 bits (294), Expect = 2e-025
Identities = 74/222 (33%), Positives = 111/222 (50%), Gaps = 3/222 (1%)
Frame = +3
Query: 732 EVDLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHQYLKEKGGLTPATAVNFALDI 911
EV L+ +LRHPNI++F+G + L +TEY+ GG L Q L L+ ++ ALDI
Sbjct: 95 EVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDI 154
Query: 912 ARGMTYLHNEPNVIIHRDLKPRNVLLVNSSADHLK-VGDFGLSKLIKVQNSHDVYKMTGE 1088
A+G+ YLH + + HRDL +N L+ VGDFGL++ I V +
Sbjct: 155 AQGLRYLHAKG--VFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGTRKEPLAV 212
Query: 1089 TGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPPFANYEPYEAAKHVSDGHRPTF 1268
GS +MAPEV + YD+K DVF+F ++L E++ P +Y P + T
Sbjct: 213 VGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTL 272
Query: 1269 RSKGCTPDLRELIVKCWDADMNQRPSFLDILKRLDKIKETLP 1394
C L + C + + R F +I + L++I E P
Sbjct: 273 VGNDCPLPFLLLAIHCCSMEPSTRAPFTEITQHLEQILEQQP 314
>sp|Q86AE1|Y9853_DICDI Probable serine/threonine-protein kinase DDB_G0271538
OS=Dictyostelium discoideum GN=DDB_G0271538 PE=3 SV=1
Length = 527
Score = 114 bits (284), Expect = 2e-024
Identities = 66/189 (34%), Positives = 111/189 (58%), Gaps = 10/189 (5%)
Frame = +3
Query: 642 KAYWRGTPVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLIT 821
KA + GT VAVK++ +S D + E+ +L +RHPNIVQ++GA M++T
Sbjct: 49 KASYFGTDVAVKQLSTLVSIDPDYFKFMLREIKILKGMRHPNIVQYIGACCHEGRYMIVT 108
Query: 822 EYLRGGDLHQYLKEKG--GLTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLL-- 989
EY++GGDLHQ++K +G ++ + ALDIA +YLH++ +I RDLK +N+L+
Sbjct: 109 EYIKGGDLHQFIKARGVSNISWTLRMKLALDIASAFSYLHSKK--VIFRDLKAKNILVDE 166
Query: 990 VNSSADHLKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRKYDKKVDVFSFA 1169
+ KV DFG +++ ++++++ GS M+PEV Y+ DV+S+
Sbjct: 167 IGDGLYRAKVIDFGFARIFDGKDTNNL----TICGSENTMSPEVIVGSSYNDSCDVYSYG 222
Query: 1170 MILYEMLEG 1196
++L E++ G
Sbjct: 223 VLLLELICG 231
>sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3
OS=Arabidopsis thaliana GN=ANP3 PE=1 SV=1
Length = 651
Score = 109 bits (272), Expect = 6e-023
Identities = 73/244 (29%), Positives = 125/244 (51%), Gaps = 16/244 (6%)
Frame = +3
Query: 657 GTPVAVKRIL--PSLSDDRLV---IQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLIT 821
G +A+K++L PS + I++ EV LL L HPNIV++LG V E L ++
Sbjct: 91 GELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPNIVRYLGTVRESDSLNILM 150
Query: 822 EYLRGGDLHQYLKEKGGLTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSS 1001
E++ GG + L++ G + + + G+ YLHN N I+HRD+K N+L+ N
Sbjct: 151 EFVPGGSISSLLEKFGSFPEPVIIMYTKQLLLGLEYLHN--NGIMHRDIKGANILVDNKG 208
Query: 1002 ADHLKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILY 1181
+++ DFG SK KV V G+ +MAPEV + D++S +
Sbjct: 209 C--IRLADFGASK--KVVELATVNGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVI 264
Query: 1182 EMLEGEPPFA-NYEPYEAAKHV--SDGHRPTFRSKGCTPDLRELIVKCWDADMNQRPSFL 1352
EM G+PP++ Y+ + A H+ + H P + +P+ ++ ++KC + + R S
Sbjct: 265 EMATGKPPWSEQYQQFAAVLHIGRTKAHPPI--PEDLSPEAKDFLMKCLHKEPSLRLSAT 322
Query: 1353 DILK 1364
++L+
Sbjct: 323 ELLQ 326
>sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinase kinase 2
OS=Arabidopsis thaliana GN=ANP2 PE=2 SV=1
Length = 651
Score = 108 bits (269), Expect = 1e-022
Identities = 77/259 (29%), Positives = 127/259 (49%), Gaps = 19/259 (7%)
Frame = +3
Query: 657 GTPVAVKRIL-----PSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLIT 821
G +AVK++L S + IQ+ EV LL L HPNIV++LG V E + L ++
Sbjct: 91 GELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDETLNILL 150
Query: 822 EYLRGGDLHQYLKEKGGLTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSS 1001
E++ GG + L++ G + + + G+ YLHN + I+HRD+K N+L+ N
Sbjct: 151 EFVPGGSISSLLEKFGAFPESVVRTYTNQLLLGLEYLHN--HAIMHRDIKGANILVDNQG 208
Query: 1002 ADHLKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILY 1181
+K+ DFG SK +V + G+ +MAPEV + D++S +
Sbjct: 209 C--IKLADFGASK--QVAELATISGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVI 264
Query: 1182 EMLEGEPPFA-NYEPYEAAKHV--SDGHRPTFRSKGCTPDLRELIVKCWDADMNQRPSFL 1352
EM+ G+ P++ Y+ A H+ + H P + D + ++KC + N RP+
Sbjct: 265 EMVTGKAPWSQQYKEIAAIFHIGTTKSHPPI--PDNISSDANDFLLKCLQQEPNLRPTAS 322
Query: 1353 DILKR---LDKIKETLPSD 1400
++LK K KE+ D
Sbjct: 323 ELLKHPFVTGKQKESASKD 341
>sp|Q13233|M3K1_HUMAN Mitogen-activated protein kinase kinase kinase 1 OS=Homo
sapiens GN=MAP3K1 PE=1 SV=4
Length = 1512
Score = 106 bits (263), Expect = 7e-022
Identities = 59/187 (31%), Positives = 102/187 (54%), Gaps = 6/187 (3%)
Frame = +3
Query: 657 GTPVAVKRIL---PSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLITEY 827
GT +AVK++ + S+ V++ R E+ ++ L HPNI++ LGA E+ L E+
Sbjct: 1266 GTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEW 1325
Query: 828 LRGGDLHQYLKEKGGLTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSSAD 1007
+ GG + L + G + +N+ + RG++YLH N IIHRD+K N LL++S+
Sbjct: 1326 MAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE--NQIIHRDVKGAN-LLIDSTGQ 1382
Query: 1008 HLKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEM 1187
L++ DFG + + + + G+ +MAPEV + ++Y + DV+S + EM
Sbjct: 1383 RLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEM 1442
Query: 1188 LEGEPPF 1208
+PP+
Sbjct: 1443 ACAKPPW 1449
>sp|P53349|M3K1_MOUSE Mitogen-activated protein kinase kinase kinase 1 OS=Mus
musculus GN=Map3k1 PE=1 SV=3
Length = 1493
Score = 106 bits (262), Expect = 9e-022
Identities = 59/187 (31%), Positives = 102/187 (54%), Gaps = 6/187 (3%)
Frame = +3
Query: 657 GTPVAVKRIL---PSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLITEY 827
GT +AVK++ + S+ V++ R E+ ++ L HPNI++ LGA E+ L E+
Sbjct: 1247 GTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMGHLNHPNIIRMLGATCEKSNYNLFIEW 1306
Query: 828 LRGGDLHQYLKEKGGLTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSSAD 1007
+ GG + L + G + +N+ + RG++YLH N IIHRD+K N LL++S+
Sbjct: 1307 MAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE--NQIIHRDVKGAN-LLIDSTGQ 1363
Query: 1008 HLKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEM 1187
L++ DFG + + + + G+ +MAPEV + ++Y + DV+S + EM
Sbjct: 1364 RLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEM 1423
Query: 1188 LEGEPPF 1208
+PP+
Sbjct: 1424 ACAKPPW 1430
>sp|Q9HFW2|CLA4_ASHGO Serine/threonine-protein kinase CLA4 OS=Ashbya gossypii
GN=CLA4 PE=3 SV=1
Length = 793
Score = 104 bits (258), Expect = 2e-021
Identities = 78/248 (31%), Positives = 126/248 (50%), Gaps = 28/248 (11%)
Frame = +3
Query: 657 GTPVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERK-PLMLITEYLR 833
G VA+K+++ S + +I +E+ ++ +H NIV FL A + + L ++ EY+
Sbjct: 539 GDKVAIKQMILSKQPRKELIV---NEILVMKDSQHKNIVNFLEAYLKTEDDLWVVMEYME 595
Query: 834 GGDLHQYLKEKGG-------LTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLV 992
GG L ++ G +T + +G+ +LH++ IIHRD+K NVLL
Sbjct: 596 GGSLTDVIENSIGSDASESPMTEPQIAYIVRETCQGLKFLHDKH--IIHRDIKSDNVLL- 652
Query: 993 NSSADHLKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRKYDKKVDVFSFAM 1172
+ +K+ DFG + + S K G+ +MAPEV K R+YD+KVDV+S +
Sbjct: 653 -DTHGRVKITDFGFCAKLTDKRS----KRATMVGTPYWMAPEVVKQREYDEKVDVWSLGI 707
Query: 1173 ILYEMLEGEPPFANYEPYEAAKHVSDGHRPTFRSKGCTPDLRELIVK-----CWDADMNQ 1337
+ EMLEGEPP+ N EP +A ++ P + P+L L +K C D+
Sbjct: 708 MTIEMLEGEPPYLNEEPLKALYLIATNGTPKLKH----PELLSLEIKRFLSVCLCVDVRY 763
Query: 1338 RPSFLDIL 1361
R S ++L
Sbjct: 764 RASTEELL 771
>sp|Q62925|M3K1_RAT Mitogen-activated protein kinase kinase kinase 1 OS=Rattus
norvegicus GN=Map3k1 PE=1 SV=1
Length = 1493
Score = 104 bits (257), Expect = 3e-021
Identities = 58/187 (31%), Positives = 101/187 (54%), Gaps = 6/187 (3%)
Frame = +3
Query: 657 GTPVAVKRIL---PSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLITEY 827
GT +AVK++ + S+ V++ R E+ ++ L HPNI++ LGA E+ L E+
Sbjct: 1247 GTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEW 1306
Query: 828 LRGGDLHQYLKEKGGLTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSSAD 1007
+ G + L + G + +N+ + RG++YLH N IIHRD+K N LL++S+
Sbjct: 1307 MAGASVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE--NQIIHRDVKGAN-LLIDSTGQ 1363
Query: 1008 HLKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEM 1187
L++ DFG + + + + G+ +MAPEV + ++Y + DV+S + EM
Sbjct: 1364 RLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEM 1423
Query: 1188 LEGEPPF 1208
+PP+
Sbjct: 1424 ACAKPPW 1430
>sp|Q54XY6|Y0019_DICDI Probable serine/threonine-protein kinase DDB_G0278521
OS=Dictyostelium discoideum GN=DDB_G0278521 PE=3 SV=1
Length = 908
Score = 103 bits (256), Expect = 4e-021
Identities = 66/156 (42%), Positives = 88/156 (56%), Gaps = 11/156 (7%)
Frame = +3
Query: 900 ALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGLSKLIKVQNSHDVYKM 1079
+L+IA GM YLH+ IIHRDL +N+L+ + K+ DFG+S+ +N M
Sbjct: 656 SLNIANGMNYLHSLKPQIIHRDLTSQNILIDRNGI--AKIADFGISRF---KNDIGDKTM 710
Query: 1080 TGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPPFANYEPYEAAKHVSDGHR 1259
T G+ R+ +PEV K +KY +KVDVF F MILYEM PF +YE A+ +++ R
Sbjct: 711 T-SIGNPRFRSPEVTKGQKYSEKVDVFGFGMILYEMFTRRVPFHDYEQIAASFKIANAER 769
Query: 1260 PTFRSKGCTPDLR--ELIVKCWDADMNQRPSFLDIL 1361
P T D R LI CWD + N RPSF IL
Sbjct: 770 PPLPQ---TIDHRWSNLIQICWDQNPNNRPSFDQIL 802
>sp|P48562|CLA4_YEAST Serine/threonine-protein kinase CLA4 OS=Saccharomyces
cerevisiae GN=CLA4 PE=1 SV=1
Length = 842
Score = 101 bits (249), Expect = 3e-020
Identities = 72/244 (29%), Positives = 124/244 (50%), Gaps = 20/244 (8%)
Frame = +3
Query: 657 GTPVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGA-VTERKPLMLITEYLR 833
G VA+K+++ S + +I +E+ ++ RH NIV FL A + L ++ E++
Sbjct: 588 GDKVAIKQMVLSKQPRKELIV---NEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFME 644
Query: 834 GGDLHQYLKEK-------GGLTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLV 992
GG L ++ LT + +G+ +LH++ IIHRD+K NVLL
Sbjct: 645 GGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKH--IIHRDIKSDNVLL- 701
Query: 993 NSSADHLKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRKYDKKVDVFSFAM 1172
+ +K+ DFG + + S K G+ +MAPEV K R+YD+K+DV+S +
Sbjct: 702 -DTRARVKITDFGFCARLTDKRS----KRATMVGTPYWMAPEVVKQREYDEKIDVWSLGI 756
Query: 1173 ILYEMLEGEPPFANYEPYEAAKHVSDGHRPTFR-SKGCTPDLRELIVKCWDADMNQRPSF 1349
+ EMLEGEPP+ N +P +A ++ P + + + +++ + C D+ R S
Sbjct: 757 MTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRAST 816
Query: 1350 LDIL 1361
++L
Sbjct: 817 EELL 820
>sp|O14427|CLA4_CANAL Serine/threonine-protein kinase CLA4 OS=Candida albicans
GN=CLA4 PE=3 SV=1
Length = 971
Score = 99 bits (245), Expect = 8e-020
Identities = 71/232 (30%), Positives = 122/232 (52%), Gaps = 19/232 (8%)
Frame = +3
Query: 729 HEVDLLVKLRHPNIVQFLGA-VTERKPLMLITEYLRGGDLHQYLKEKG-GLTPATAVNFA 902
+E+ ++ +H NIV FL + + L +I EY++GG L + ++ L
Sbjct: 725 NEILVMKDSQHKNIVNFLDSYLIGDNELWVIMEYMQGGSLTEIIENNDFKLNEKQIATIC 784
Query: 903 LDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGL-SKLIKVQNSHDVYKM 1079
+ +G+ +LH + IIHRD+K NVLL + ++K+ DFG +KL +N K
Sbjct: 785 FETLKGLQHLHKKH--IIHRDIKSDNVLL--DAYGNVKITDFGFCAKLTDQRN-----KR 835
Query: 1080 TGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPPFANYEPYEAAKHVSDGHR 1259
G+ +MAPEV K ++YD+KVDV+S ++ EM+EGEPP+ N EP +A ++
Sbjct: 836 ATMVGTPYWMAPEVVKQKEYDEKVDVWSLGIMTIEMIEGEPPYLNEEPLKALYLIATNGT 895
Query: 1260 PTFRS-KGCTPDLRELIVKCWDADMNQRPSFLDILK------RLDKIKETLP 1394
P + + + +++ + C D+ R S ++L+ + KI+E P
Sbjct: 896 PKLKKPELLSNSIKKFLSICLCVDVRYRASTDELLEHSFIQHKSGKIEELAP 947
>sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase DDB_G0267514
OS=Dictyostelium discoideum GN=DDB_G0267514 PE=3 SV=1
Length = 916
Score = 94 bits (231), Expect = 3e-018
Identities = 57/135 (42%), Positives = 81/135 (60%), Gaps = 5/135 (3%)
Frame = +3
Query: 642 KAYWRGTPVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLIT 821
K WRG+ VA+K+I + + V+++FR E+ +L +LRHPNIV + A T L IT
Sbjct: 678 KGLWRGSSVAIKQIKINEDVNNQVLEEFRKELTILSRLRHPNIVLLMAACTAPPNLCFIT 737
Query: 822 EYLRGGDLHQYL-KEKGGLTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNS 998
EYL GG L+ L +K + A+ IA+GM YLH + +IHRD+K N+LL
Sbjct: 738 EYLPGGSLYDALHSKKIKMNMQLYKKLAIQIAQGMNYLH--LSGVIHRDIKSLNLLL--D 793
Query: 999 SADHLKVGDFGLSKL 1043
++K+ DFGLSKL
Sbjct: 794 EHMNVKICDFGLSKL 808
>sp|O22040|ANP1_ARATH Mitogen-activated protein kinase kinase kinase ANP1
OS=Arabidopsis thaliana GN=ANP1 PE=1 SV=2
Length = 666
Score = 93 bits (229), Expect = 6e-018
Identities = 60/190 (31%), Positives = 97/190 (51%), Gaps = 11/190 (5%)
Frame = +3
Query: 657 GTPVAVKRIL-----PSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTERKPLMLIT 821
G +AVK++L S + IQ+ EV LL L HPNIV++LG V E L ++
Sbjct: 92 GELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDDTLNILL 151
Query: 822 EYLRGGDLHQYLKEKGGLTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPRNVLLVNSS 1001
E++ GG + L++ G + + + G+ YLHN + I+HRD+K N+L+ N
Sbjct: 152 EFVPGGSISSLLEKFGPFPESVVRTYTRQLLLGLEYLHN--HAIMHRDIKGANILVDNKG 209
Query: 1002 ADHLKVGDFGLSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILY 1181
+K+ DFG SK +V + G+ +MAPEV + D++S +
Sbjct: 210 C--IKLADFGASK--QVAELATMTGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVI 265
Query: 1182 EMLEGEPPFA 1211
EM+ G+ P++
Sbjct: 266 EMVTGKAPWS 275
>sp|Q96S53|TESK2_HUMAN Dual specificity testis-specific protein kinase 2 OS=Homo
sapiens GN=TESK2 PE=2 SV=1
Length = 571
Score = 92 bits (228), Expect = 7e-018
Identities = 57/154 (37%), Positives = 85/154 (55%), Gaps = 5/154 (3%)
Frame = +3
Query: 732 EVDLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHQYLKEKGGLTPATAVNFALDI 911
EV L+ +L HPNI++F+G + L +TEY+ G+L Q L L V A DI
Sbjct: 101 EVQLMNRLSHPNILRFMGVCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDI 160
Query: 912 ARGMTYLHNEPNVIIHRDLKPRNVLLVNSSADH-LKVGDFGLSKLIKVQNSHDVYKMTGE 1088
A G++YLH + I HRDL +N L+ + V DFGL++ K+ + +
Sbjct: 161 AVGLSYLHFKG--IFHRDLTSKNCLIKRDENGYSAVVADFGLAE--KIPDVSMGSEKLAV 216
Query: 1089 TGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEML 1190
GS +MAPEV + Y++K DVFS+ +IL E++
Sbjct: 217 VGSPFWMAPEVLRDEPYNEKADVFSYGIILCEII 250
>sp|O64629|AUR3_ARATH Serine/threonine-protein kinase Aurora-3 OS=Arabidopsis
thaliana GN=AUR3 PE=2 SV=1
Length = 288
Score = 84 bits (205), Expect = 3e-015
Identities = 48/140 (34%), Positives = 76/140 (54%), Gaps = 7/140 (5%)
Frame = +3
Query: 618 RVHLVRFVKAYWRGTPVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGAVTE 797
RV+L R K+ + VA+K I + + R E+++ LRHPNI++ G +
Sbjct: 35 RVYLAREAKSKY---IVALKVIFKEQIEKYKIHHQLRREMEIQTSLRHPNILRLFGWFHD 91
Query: 798 RKPLMLITEYLRGGDLHQYLKEKGGLTPATAVNFALDIARGMTYLHNEPNVIIHRDLKPR 977
+ + LI EY GG+L+ LK+ G LT A + +++ + Y H + +IHRD+KP
Sbjct: 92 NERIFLILEYAHGGELYGVLKQNGHLTEQQAATYIASLSQALAYCHGK--CVIHRDIKPE 149
Query: 978 NVLLVNSSADHLKVGDFGLS 1037
N+LL + LK+ DFG S
Sbjct: 150 NLLLDHEG--RLKIADFGWS 167
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,370,385,861
Number of Sequences: 518415
Number of Extensions: 64370385861
Number of Successful Extensions: 454073489
Number of sequences better than 0.0: 0
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