BLASTX 7.6.2
Query= UN16000 /QuerySize=1218
(1217 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q55135|PURU_SYNY3 Formyltetrahydrofolate deformylase OS=Synec... 193 2e-048
sp|O34990|PURU_BACSU Formyltetrahydrofolate deformylase OS=Bacil... 192 6e-048
sp|P0A5T7|PURU_MYCBO Formyltetrahydrofolate deformylase OS=Mycob... 161 9e-039
sp|P0A5T6|PURU_MYCTU Formyltetrahydrofolate deformylase OS=Mycob... 161 9e-039
sp|Q46339|PURU_CORS1 Formyltetrahydrofolate deformylase OS=Coryn... 156 5e-037
sp|Q03432|PURU_HAEIN Formyltetrahydrofolate deformylase OS=Haemo... 135 7e-031
sp|P0A440|PURU_ECOL6 Formyltetrahydrofolate deformylase OS=Esche... 125 7e-028
sp|P0A441|PURU_SHIFL Formyltetrahydrofolate deformylase OS=Shige... 125 7e-028
sp|P37051|PURU_ECOLI Formyltetrahydrofolate deformylase OS=Esche... 125 9e-028
sp|P12040|PUR3_BACSU Phosphoribosylglycinamide formyltransferase... 90 3e-017
sp|Q64737|PUR2_MOUSE Trifunctional purine biosynthetic protein a... 86 5e-016
sp|P43846|PUR3_HAEIN Phosphoribosylglycinamide formyltransferase... 83 3e-015
sp|P21872|PUR2_CHICK Trifunctional purine biosynthetic protein a... 82 5e-015
sp|Q59A32|PUR2_BOVIN Trifunctional purine biosynthetic protein a... 82 7e-015
sp|P22102|PUR2_HUMAN Trifunctional purine biosynthetic protein a... 80 3e-014
sp|P08179|PUR3_ECOLI Phosphoribosylglycinamide formyltransferase... 71 1e-011
sp|P16340|PUR2_DROPS Trifunctional purine biosynthetic protein a... 70 3e-011
sp|Q5HH12|PUR3_STAAC Phosphoribosylglycinamide formyltransferase... 69 6e-011
sp|Q6GI12|PUR3_STAAR Phosphoribosylglycinamide formyltransferase... 68 1e-010
sp|Q6GAE1|PUR3_STAAS Phosphoribosylglycinamide formyltransferase... 68 1e-010
>sp|Q55135|PURU_SYNY3 Formyltetrahydrofolate deformylase OS=Synechocystis sp.
(strain PCC 6803) GN=purU PE=3 SV=1
Length = 284
Score = 193 bits (490), Expect = 2e-048
Identities = 106/282 (37%), Positives = 170/282 (60%), Gaps = 14/282 (4%)
Frame = +2
Query: 200 CPDVVGIVAKLSDCIAAKGGNILGYDVFVPENNNVFYSRSEFIFDPVKWPRSQMSEDFHT 379
CPD GIVA+++ I GNI+ D ++ +F +R E+ D + R ++ +
Sbjct: 12 CPDQPGIVAQIAQFIYQNQGNIIHADQHTDFSSGLFLNRVEWQLDNFRLSRPELLSAWSQ 71
Query: 380 IAKKFNAMSSVVRVPSLDPKYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNHERA 559
+A++ A ++ D ++AL +SKQDHCL+++L +W+ G+L +I +ISNH
Sbjct: 72 LAEQLQA---TWQIHFSDQLPRLALWVSKQDHCLLDILWRWRSGELRCEIPLIISNH--- 125
Query: 560 PNTHIMRFLQRHGISYHYLPTTDQNKIEEEIFELV----KDTDFIVLARYMQVLSGNFLK 727
+ + GI +H LP T +NK+ +E EL D +VLA+Y+Q+L+ +F+
Sbjct: 126 --PDLKSIADQFGIDFHCLPITKENKLAQETAELALLKQYQIDLVVLAKYLQILTTDFVV 183
Query: 728 GYGKDVINIHHGLLPSFKGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSH 907
+ ++INIHH LP+F G +P +A + GVK+IGAT H+ T +LD GPIIEQ V RVSH
Sbjct: 184 QF-PNIINIHHSFLPAFPGANPYHRAHERGVKIIGATAHYATAQLDEGPIIEQDVVRVSH 242
Query: 908 RDNLTSFVQKSEDLEKKCLMKAIKSYCELRVLPYGTHKTVVF 1033
RDN+ ++K DLE+ L +A++ + + R+L Y ++TVVF
Sbjct: 243 RDNVDDLIRKGRDLERVVLARAVRLHLQHRILVY-DNRTVVF 283
>sp|O34990|PURU_BACSU Formyltetrahydrofolate deformylase OS=Bacillus subtilis
GN=purU PE=3 SV=2
Length = 300
Score = 192 bits (486), Expect = 6e-048
Identities = 110/284 (38%), Positives = 171/284 (60%), Gaps = 16/284 (5%)
Frame = +2
Query: 200 CPDVVGIVAKLSDCIAAKGGNILGYDVFV--PENNNVFYSRSEFIFDPVKWPRSQMSEDF 373
CPD GIV+ +S + G NI+ + + PE F+ R EF ++ +S + F
Sbjct: 26 CPDQPGIVSAVSAFLFEHGANIIESNQYTTDPEGGR-FFLRIEFDCAGIREKKSSLQAAF 84
Query: 374 HTIAKKFNAMSSVVRVPSLDPKYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNHE 553
++A+KF+ S+ L ++A+ +SK+ HCL E++ +WQ G L +I VISNHE
Sbjct: 85 ASVAEKFDMTWSLTLASELK---RVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHE 141
Query: 554 RAPNTHIMRFLQRHGISYHYLPTTD--QNKIEEEIFELVK--DTDFIVLARYMQVLSGNF 721
A ++R I +HY+ + ++E++ EL++ D D IVLARYMQ+L+ +F
Sbjct: 142 EA-----RELVERLNIPFHYMKANKDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDF 196
Query: 722 LKGYGKDVINIHHGLLPSFKGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERV 901
+ + +INIHH LP+F G +P K+A++ GVKLIGAT+H+VT +LD GPIIEQ +ERV
Sbjct: 197 VSAHPNRIINIHHSFLPAFIGANPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERV 256
Query: 902 SHRDNLTSFVQKSEDLEKKCLMKAIKSYCELRVLPYGTHKTVVF 1033
HRDN + +E+ L +A+K + E RV+ + +KT+VF
Sbjct: 257 DHRDNAEALKNIGRTIERSVLARAVKWHLEDRVIVH-ENKTIVF 299
>sp|P0A5T7|PURU_MYCBO Formyltetrahydrofolate deformylase OS=Mycobacterium bovis
GN=purU PE=3 SV=1
Length = 310
Score = 161 bits (407), Expect = 9e-039
Identities = 101/277 (36%), Positives = 153/277 (55%), Gaps = 15/277 (5%)
Frame = +2
Query: 191 VFHCPDVVGIVAKLSDCIAAKGGNILGYDVF--VPENNNVFYSRSEFIFDPVKWPRSQMS 364
+ C D GI+A +S +A G NI+ D PE F R+ F + ++
Sbjct: 34 LLRCHDRPGIIAAVSTFLARAGANIISLDQHSTAPE-GGTFLQRAIFHLPGLTAAVDELQ 92
Query: 365 EDF-HTIAKKFNAMSSVVRVPSLDPKYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVI 541
DF T+A KF + PK ++A++ S +DHCL+++L + + G+L + + VI
Sbjct: 93 RDFGSTVADKFGIDYRFAE--AAKPK-RVAIMASTEDHCLLDLLWRNRRGELEMSVVMVI 149
Query: 542 SNHERAPNTHIMRFLQRHGISYHYLPTTDQNKIEEE---IFELVKDTDFIVLARYMQVLS 712
+NH H+ F G+ + ++P T + E E + L + D +VLARYMQ+LS
Sbjct: 150 ANHPDLA-AHVRPF----GVPFIHIPATRDTRTEAEQRQLQLLSGNVDLVVLARYMQILS 204
Query: 713 GNFLKGYGKDVINIHHGLLPSFKGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMV 892
FL+ G +INIHH LP+F G +P ++A + GVKLIGAT H+VTE LD GPIIEQ V
Sbjct: 205 PGFLEAIGCPLINIHHSFLPAFTGAAPYQRARERGVKLIGATAHYVTEVLDEGPIIEQDV 264
Query: 893 ERVSHRDNLTSFVQKSEDLEKKCLMKAIKSYCELRVL 1003
RV H + V+ D+E+ L +A+ +C+ RV+
Sbjct: 265 VRVDHTHTVDDLVRVGADVERAVLSRAVLWHCQDRVI 301
>sp|P0A5T6|PURU_MYCTU Formyltetrahydrofolate deformylase OS=Mycobacterium
tuberculosis GN=purU PE=3 SV=1
Length = 310
Score = 161 bits (407), Expect = 9e-039
Identities = 101/277 (36%), Positives = 153/277 (55%), Gaps = 15/277 (5%)
Frame = +2
Query: 191 VFHCPDVVGIVAKLSDCIAAKGGNILGYDVF--VPENNNVFYSRSEFIFDPVKWPRSQMS 364
+ C D GI+A +S +A G NI+ D PE F R+ F + ++
Sbjct: 34 LLRCHDRPGIIAAVSTFLARAGANIISLDQHSTAPE-GGTFLQRAIFHLPGLTAAVDELQ 92
Query: 365 EDF-HTIAKKFNAMSSVVRVPSLDPKYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVI 541
DF T+A KF + PK ++A++ S +DHCL+++L + + G+L + + VI
Sbjct: 93 RDFGSTVADKFGIDYRFAE--AAKPK-RVAIMASTEDHCLLDLLWRNRRGELEMSVVMVI 149
Query: 542 SNHERAPNTHIMRFLQRHGISYHYLPTTDQNKIEEE---IFELVKDTDFIVLARYMQVLS 712
+NH H+ F G+ + ++P T + E E + L + D +VLARYMQ+LS
Sbjct: 150 ANHPDLA-AHVRPF----GVPFIHIPATRDTRTEAEQRQLQLLSGNVDLVVLARYMQILS 204
Query: 713 GNFLKGYGKDVINIHHGLLPSFKGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMV 892
FL+ G +INIHH LP+F G +P ++A + GVKLIGAT H+VTE LD GPIIEQ V
Sbjct: 205 PGFLEAIGCPLINIHHSFLPAFTGAAPYQRARERGVKLIGATAHYVTEVLDEGPIIEQDV 264
Query: 893 ERVSHRDNLTSFVQKSEDLEKKCLMKAIKSYCELRVL 1003
RV H + V+ D+E+ L +A+ +C+ RV+
Sbjct: 265 VRVDHTHTVDDLVRVGADVERAVLSRAVLWHCQDRVI 301
>sp|Q46339|PURU_CORS1 Formyltetrahydrofolate deformylase OS=Corynebacterium sp.
(strain P-1) GN=purU PE=3 SV=1
Length = 286
Score = 156 bits (392), Expect = 5e-037
Identities = 99/286 (34%), Positives = 148/286 (51%), Gaps = 13/286 (4%)
Frame = +2
Query: 185 VHVFHCPDVVGIVAKLSDCIAAKGGNILGYDVFVPENNNVFYSRSEFIFDPVKWPRSQMS 364
V CP+ +GIV ++ + I+ + + + R +F D +
Sbjct: 8 VLTLQCPEGIGIVHAVTGFLVRHQRTIVELKQYDDMSAGRLFLRVDFAGDSAPDLLDALR 67
Query: 365 EDFHTIAKKFNAMSSVVRVPSLDPKYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVIS 544
+F +A KF+ M +R K K+ +++SK +HCL ++L + G LP+++ V S
Sbjct: 68 SEFSEVAAKFD-MDWQLR--ERGQKTKVLIMVSKFEHCLQDLLFRMHSGDLPIEVVGVAS 124
Query: 545 NHERAPNTHIMRFLQRHGISYHYLPTTDQNK--IEEEIFELVKDT--DFIVLARYMQVLS 712
NH P+ + ++ +GI +H++P + K E + EL+ T + +VLARYMQVLS
Sbjct: 125 NH---PDHRSL--VEWYGIGFHHIPISKDTKPRAEAALLELIDQTGAELVVLARYMQVLS 179
Query: 713 GNFLKGYGKDVINIHHGLLPSFKGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMV 892
+ INIHH LPSFKG P QA++ GVK +GAT H+V ELD GPII Q V
Sbjct: 180 DHLASELTGKTINIHHSFLPSFKGAKPYHQAWERGVKTVGATAHYVNSELDEGPIIAQQV 239
Query: 893 ERVSHRDNLTSFVQKSEDLEKKCLMKAIKSYCELRVLPYGTHKTVV 1030
V H V D E K L A++ +CE RV YG ++TVV
Sbjct: 240 VEVDHTYGPQDLVAAGRDSECKALSNAVRWHCEGRVFLYG-NRTVV 284
>sp|Q03432|PURU_HAEIN Formyltetrahydrofolate deformylase OS=Haemophilus
influenzae GN=purU PE=3 SV=2
Length = 278
Score = 135 bits (339), Expect = 7e-031
Identities = 77/200 (38%), Positives = 117/200 (58%), Gaps = 10/200 (5%)
Frame = +2
Query: 443 KIALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNHERAPNTHIMRFLQRHGISYHYLPT 622
+I +L++K+ HCL ++L K G L V+I VI NH+ ++ ++R I +H +
Sbjct: 84 RIVILVTKEAHCLGDILMKNYYGALDVEIAAVIGNHD-----NLRELVERFNIPFHLVSH 138
Query: 623 TDQNKIEEE--IFELVKD--TDFIVLARYMQVLSGNFLKGYGKDVINIHHGLLPSFKGRS 790
+ ++E + + E + + D+IVLA+YM+VL+ F+ Y VINIHH LP+F G
Sbjct: 139 ENLTRVEHDKLLAEKIDEYTPDYIVLAKYMRVLNPEFVARYPNRVINIHHSFLPAFIGAK 198
Query: 791 PAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKSEDLEKKCLMK 970
P +QA+ GVK+IGAT HF+ ELD GPII Q V V H N + ++ D+EK L +
Sbjct: 199 PYQQAYKRGVKIIGATAHFINNELDQGPIIMQNVINVDHTYNAEAMMRAGRDVEKTVLSR 258
Query: 971 AIKSYCELRVLPYGTHKTVV 1030
A+ R+ Y +KTVV
Sbjct: 259 ALDLALHDRIFVY-KNKTVV 277
>sp|P0A440|PURU_ECOL6 Formyltetrahydrofolate deformylase OS=Escherichia coli O6
GN=purU PE=3 SV=1
Length = 280
Score = 125 bits (313), Expect = 7e-028
Identities = 72/210 (34%), Positives = 119/210 (56%), Gaps = 12/210 (5%)
Frame = +2
Query: 419 VPSLDP--KYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNHERAPNTHIMRFLQR 592
V L+P + +I +L++K+ HCL ++L K G L V+I VI NH+ + ++R
Sbjct: 76 VRELNPAGRRRIVILVTKEAHCLGDLLMKANYGGLDVEIAAVIGNHDT-----LRSLVER 130
Query: 593 HGISYHYL--PTTDQNKIEEEIFELVK--DTDFIVLARYMQVLSGNFLKGYGKDVINIHH 760
I + + +N+ ++++ + + D++VLA+YM+VL+ F+ + +INIHH
Sbjct: 131 FDIPFELVSHEGLSRNEHDQKMADAIDAYQPDYVVLAKYMRVLTPEFVARFPNKIINIHH 190
Query: 761 GLLPSFKGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKS 940
LP+F G P QA++ GVK+IGAT H+V + LD GPII Q V V H ++
Sbjct: 191 SFLPAFIGARPYHQAYERGVKIIGATAHYVNDNLDEGPIIMQDVIHVDHTYTAEDMMRAG 250
Query: 941 EDLEKKCLMKAIKSYCELRVLPYGTHKTVV 1030
D+EK L +A+ RV YG ++T++
Sbjct: 251 RDVEKNVLSRALYKVLAQRVFVYG-NRTII 279
>sp|P0A441|PURU_SHIFL Formyltetrahydrofolate deformylase OS=Shigella flexneri
GN=purU PE=3 SV=1
Length = 280
Score = 125 bits (313), Expect = 7e-028
Identities = 72/210 (34%), Positives = 119/210 (56%), Gaps = 12/210 (5%)
Frame = +2
Query: 419 VPSLDP--KYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNHERAPNTHIMRFLQR 592
V L+P + +I +L++K+ HCL ++L K G L V+I VI NH+ + ++R
Sbjct: 76 VRELNPAGRRRIVILVTKEAHCLGDLLMKANYGGLDVEIAAVIGNHDT-----LRSLVER 130
Query: 593 HGISYHYL--PTTDQNKIEEEIFELVK--DTDFIVLARYMQVLSGNFLKGYGKDVINIHH 760
I + + +N+ ++++ + + D++VLA+YM+VL+ F+ + +INIHH
Sbjct: 131 FDIPFELVSHEGLSRNEHDQKMADAIDAYQPDYVVLAKYMRVLTPEFVARFPNKIINIHH 190
Query: 761 GLLPSFKGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKS 940
LP+F G P QA++ GVK+IGAT H+V + LD GPII Q V V H ++
Sbjct: 191 SFLPAFIGARPYHQAYERGVKIIGATAHYVNDNLDEGPIIMQDVIHVDHTYTAEDMMRAG 250
Query: 941 EDLEKKCLMKAIKSYCELRVLPYGTHKTVV 1030
D+EK L +A+ RV YG ++T++
Sbjct: 251 RDVEKNVLSRALYKVLAQRVFVYG-NRTII 279
>sp|P37051|PURU_ECOLI Formyltetrahydrofolate deformylase OS=Escherichia coli
(strain K12) GN=purU PE=1 SV=1
Length = 280
Score = 125 bits (312), Expect = 9e-028
Identities = 72/210 (34%), Positives = 119/210 (56%), Gaps = 12/210 (5%)
Frame = +2
Query: 419 VPSLDP--KYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNHERAPNTHIMRFLQR 592
V L+P + +I +L++K+ HCL ++L K G L V+I VI NH+ + ++R
Sbjct: 76 VRELNPAGRRRIVILVTKEAHCLGDLLMKANYGGLDVEIAAVIGNHDT-----LRSLVER 130
Query: 593 HGISYHYL--PTTDQNKIEEEIFELVK--DTDFIVLARYMQVLSGNFLKGYGKDVINIHH 760
I + + +N+ ++++ + + D++VLA+YM+VL+ F+ + +INIHH
Sbjct: 131 FDIPFELVSHEGLTRNEHDQKMADAIDAYQPDYVVLAKYMRVLTPEFVARFPNKIINIHH 190
Query: 761 GLLPSFKGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKS 940
LP+F G P QA++ GVK+IGAT H+V + LD GPII Q V V H ++
Sbjct: 191 SFLPAFIGARPYHQAYERGVKIIGATAHYVNDNLDEGPIIMQDVIHVDHTYTAEDMMRAG 250
Query: 941 EDLEKKCLMKAIKSYCELRVLPYGTHKTVV 1030
D+EK L +A+ RV YG ++T++
Sbjct: 251 RDVEKNVLSRALYKVLAQRVFVYG-NRTII 279
>sp|P12040|PUR3_BACSU Phosphoribosylglycinamide formyltransferase OS=Bacillus
subtilis GN=purN PE=3 SV=2
Length = 195
Score = 90 bits (222), Expect = 3e-017
Identities = 51/133 (38%), Positives = 73/133 (54%), Gaps = 4/133 (3%)
Frame = +2
Query: 593 HGISYHYLPTTDQNK--IEEEIFELVK--DTDFIVLARYMQVLSGNFLKGYGKDVINIHH 760
H S+ + P + +NK E+ I E ++ + + I LA YM+++ L+ YG +INIH
Sbjct: 51 HIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYGGKIINIHP 110
Query: 761 GLLPSFKGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKS 940
LLP+F G QAF AGVK+ G T H+V E +D+GPII Q + D L + Q+
Sbjct: 111 SLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEHDTLETIEQRI 170
Query: 941 EDLEKKCLMKAIK 979
LE K IK
Sbjct: 171 HKLEHKWYPSVIK 183
>sp|Q64737|PUR2_MOUSE Trifunctional purine biosynthetic protein adenosine-3
OS=Mus musculus GN=Gart PE=2 SV=2
Length = 1010
Score = 86 bits (211), Expect = 5e-016
Identities = 58/192 (30%), Positives = 96/192 (50%), Gaps = 10/192 (5%)
Frame = +2
Query: 422 PSLDPKYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNH------ERAPNTHIMRF 583
P K ++A+L+S L ++ +D K I VISN +RA I
Sbjct: 802 PVQQKKARVAVLISGTGSNLQALIDSTRDPKSSSHIVLVISNKAAVAGLDRAERAGIPTR 861
Query: 584 LQRHGISYHYLPTTDQNKIEEEIFELVKDTDFIVLARYMQVLSGNFLKGYGKDVINIHHG 763
+ H +S + + N ++ + E D + LA +M++LSG F++ + ++NIH
Sbjct: 862 VINHKLSKNRVEF--DNAVDHVLEEF--SVDIVCLAGFMRILSGPFVRKWDGKMLNIHPS 917
Query: 764 LLPSFKGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKSE 943
LLPSFKG + +Q +AGV + G T HFV E++D+G II Q V D + + ++ +
Sbjct: 918 LLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEAVPVRRGDTVATLSERVK 977
Query: 944 DLEKKCLMKAIK 979
E K A++
Sbjct: 978 VAEHKIFPAALQ 989
>sp|P43846|PUR3_HAEIN Phosphoribosylglycinamide formyltransferase OS=Haemophilus
influenzae GN=purN PE=3 SV=1
Length = 212
Score = 83 bits (204), Expect = 3e-015
Identities = 58/190 (30%), Positives = 95/190 (50%), Gaps = 6/190 (3%)
Frame = +2
Query: 443 KIALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNHERAPNTHIMRFLQRHGISYHYLPT 622
KIA+L+S Q L ++ G +P I CVISN +A ++R Q +L
Sbjct: 3 KIAVLISGQGTNLQTIIDACHSGDIPAKIACVISN--KADAYGLVRAKQAQIPQAVFLRK 60
Query: 623 TDQNKIE--EEIFELVKD--TDFIVLARYMQVLSGNFLKGYGKDVINIHHGLLPSFKGRS 790
N +E + I + ++ D IVLA YM++L+ F + + ++NIH LLP + G +
Sbjct: 61 NFSNNLEMDDAIGDYLQSLAVDLIVLAGYMKILTPKFTQRFAGKILNIHPSLLPKYAGLN 120
Query: 791 PAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKSEDLEKKCLMK 970
++A +AG G T HFV EE+D G I+ Q + D++ ++ + E +
Sbjct: 121 TYQRAIEAGDNEHGTTVHFVNEEVDGGAIVLQAKVPIFPEDSIEEVEARTREQEYQIYPL 180
Query: 971 AIKSYCELRV 1000
IK + E R+
Sbjct: 181 VIKWFTEGRL 190
>sp|P21872|PUR2_CHICK Trifunctional purine biosynthetic protein adenosine-3
OS=Gallus gallus GN=GART PE=2 SV=1
Length = 1003
Score = 82 bits (202), Expect = 5e-015
Identities = 56/187 (29%), Positives = 94/187 (50%), Gaps = 10/187 (5%)
Frame = +2
Query: 437 KYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNHERAPNTHIMRFLQRHGI----- 601
K K+A+L+S L +++ + +I V+SN +R +R GI
Sbjct: 803 KVKVAVLISGTGTNLEALINSTKKPTSFAEIVLVVSNKAGVEG---LRKAERAGIPTRVI 859
Query: 602 -SYHYLPTTDQNKIEEEIFELVKDTDFIVLARYMQVLSGNFLKGYGKDVINIHHGLLPSF 778
Y T+ + + + E + I LA +M++LSG F+K + ++NIH LLPSF
Sbjct: 860 DHKQYGSRTEFDSAVDRVLEEF-SVELICLAGFMRILSGPFVKKWEGKILNIHPSLLPSF 918
Query: 779 KGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKSEDLEKK 958
KG + K +AGV++ G T HFV EE+D+G II Q V D + + ++ ++ E +
Sbjct: 919 KGANAHKLVLEAGVRVTGCTVHFVAEEVDAGAIIFQEAVPVKIGDTVETLSERVKEAEHR 978
Query: 959 CLMKAIK 979
A++
Sbjct: 979 AFPAALQ 985
>sp|Q59A32|PUR2_BOVIN Trifunctional purine biosynthetic protein adenosine-3
OS=Bos taurus GN=GART PE=2 SV=1
Length = 1010
Score = 82 bits (201), Expect = 7e-015
Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 10/187 (5%)
Frame = +2
Query: 437 KYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNH------ERAPNTHIMRFLQRHG 598
K ++A+L+S L ++ ++ I VISN ++A I + H
Sbjct: 807 KARVAVLISGTGSNLQALIDSTREPSSLAHIVIVISNKAAVAGLDKAEKAGIPTRVINHK 866
Query: 599 ISYHYLPTTDQNKIEEEIFELVKDTDFIVLARYMQVLSGNFLKGYGKDVINIHHGLLPSF 778
+ Y D I+E + E TD + LA +M++LSG F++ + ++NIH LLPSF
Sbjct: 867 L-YKNRAAFD-TAIDEVLEEF--STDIVCLAGFMRILSGPFVRKWNGKMLNIHPSLLPSF 922
Query: 779 KGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKSEDLEKK 958
KG + +Q DAGV + G T HFV E++D+G II Q V D + + ++ + E K
Sbjct: 923 KGSNAHEQVLDAGVTVTGCTVHFVAEDVDAGQIILQEAVPVKRGDTVETLSERVKLAEHK 982
Query: 959 CLMKAIK 979
A++
Sbjct: 983 IFPSALQ 989
>sp|P22102|PUR2_HUMAN Trifunctional purine biosynthetic protein adenosine-3
OS=Homo sapiens GN=GART PE=1 SV=1
Length = 1010
Score = 80 bits (195), Expect = 3e-014
Identities = 55/186 (29%), Positives = 95/186 (51%), Gaps = 8/186 (4%)
Frame = +2
Query: 437 KYKIALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNHERAPNTHIMRFLQRHGISYHYL 616
K ++A+L+S L ++ ++ I VISN + +R GI +
Sbjct: 807 KARVAVLISGTGSNLQALIDSTREPNSSAQIDIVISNKAAVAG---LDKAERAGIPTRVI 863
Query: 617 -PTTDQNKIE-EEIFELVKD---TDFIVLARYMQVLSGNFLKGYGKDVINIHHGLLPSFK 781
+N++E + +LV + D + LA +M++LSG F++ + ++NIH LLPSFK
Sbjct: 864 NHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILSGPFVQKWNGKMLNIHPSLLPSFK 923
Query: 782 GRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKSEDLEKKC 961
G + +QA + GV + G T HFV E++D+G II Q V D + + ++ + E K
Sbjct: 924 GSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEAVPVKRGDTVATLSERVKLAEHKI 983
Query: 962 LMKAIK 979
A++
Sbjct: 984 FPAALQ 989
>sp|P08179|PUR3_ECOLI Phosphoribosylglycinamide formyltransferase OS=Escherichia
coli (strain K12) GN=purN PE=1 SV=1
Length = 212
Score = 71 bits (173), Expect = 1e-011
Identities = 54/174 (31%), Positives = 84/174 (48%), Gaps = 11/174 (6%)
Frame = +2
Query: 446 IALLLSKQDHCLVEMLHKWQDGKLPVDITCVISNHERAPNTHIMRFLQRHGISYHYLPTT 625
I +L+S L ++ + K+ + V SN A R + GI+ H L +
Sbjct: 3 IVVLISGNGSNLQAIIDACKTNKIKGTVRAVFSNKADAFGLERAR---QAGIATHTLIAS 59
Query: 626 DQNKIEEEIFELVKDTDF-----IVLARYMQVLSGNFLKGYGKDVINIHHGLLPSFKGRS 790
+ E EL+ + D +VLA +M++LS F+ Y ++NIH LLP + G
Sbjct: 60 AFDSREAYDRELIHEIDMYAPDVVVLAGFMRILSPAFVSHYAGRLLNIHPSLLPKYPGLH 119
Query: 791 PAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERV---SHRDNLTSFVQKSE 943
+QA + G + G + HFVT+ELD GP+I Q V D++T+ VQ E
Sbjct: 120 THRQALENGDEEHGTSVHFVTDELDGGPVILQAKVPVFAGDSEDDITARVQTQE 173
>sp|P16340|PUR2_DROPS Trifunctional purine biosynthetic protein adenosine-3
OS=Drosophila pseudoobscura pseudoobscura GN=ade3 PE=3 SV=2
Length = 1364
Score = 70 bits (170), Expect = 3e-011
Identities = 58/207 (28%), Positives = 95/207 (45%), Gaps = 12/207 (5%)
Frame = +2
Query: 380 IAKKFNAMSSVVRVPSLDPKYKIALLLSKQDHCLVEMLHKWQDGKLPV--DITCVISNH- 550
+ + F A + + P+ ++A+L+S + L ++ +D V +I VISN
Sbjct: 1136 VVQNFEASLARTQRMLSQPRKRVAVLISGKGSNLQALIDAIRDSAQGVYAEIVLVISNKA 1195
Query: 551 -----ERAPNTHIMRFLQRHGISYHYLPTTDQNKIEEEIFELVKDTDFIVLARYMQVLSG 715
ERA I + IS+ P+ + +E +FI LA +M++LS
Sbjct: 1196 GVLGLERAAKAGIPSMV----ISHKDFPSREVYDVELTRHLKTARVEFICLAGFMRILSV 1251
Query: 716 NFLKGYGKDVINIHHGLLPSFKGRSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVE 895
F++ + +INIH LLP F G KQA +AG G T H+V E +D+G II Q
Sbjct: 1252 PFVREWRGRLINIHPSLLPKFPGLHVQKQALEAGETESGCTVHYVDEGVDTGAIIVQAAV 1311
Query: 896 RVSHRDNLTSFVQKSEDLEKKCLMKAI 976
+ D+ + Q+ E +A+
Sbjct: 1312 PILPGDDEETLTQRIHYAEHWAFPRAL 1338
>sp|Q5HH12|PUR3_STAAC Phosphoribosylglycinamide formyltransferase
OS=Staphylococcus aureus (strain COL) GN=purN PE=3 SV=1
Length = 188
Score = 69 bits (167), Expect = 6e-011
Identities = 48/176 (27%), Positives = 89/176 (50%), Gaps = 9/176 (5%)
Frame = +2
Query: 443 KIALLLSKQDHCLVEMLHKWQDGKLP-VDITCVISNHERAPNTHIMRFLQRHGIS-YHYL 616
KIA+ S ++ + GKL +++T + ++H+ N + ++H I Y
Sbjct: 3 KIAIFASGSGSNFENIVEHVESGKLENIEVTALYTDHQ---NAFCIDRAKKHDIPVYINE 59
Query: 617 PTTDQNK--IEEEIFELVKD--TDFIVLARYMQVLSGNFLKGYGKDVINIHHGLLPSFKG 784
P +K E+ + L+ + ++I+LA YM+++ + L + ++NIH LLP +KG
Sbjct: 60 PKQFDSKAAYEQHLVTLLNEDKVEWIILAGYMRLIGPDLLASFEGKILNIHPSLLPKYKG 119
Query: 785 RSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKSEDLE 952
QA+ +G + G+T H+V +D+G IIEQ + D+ +K + LE
Sbjct: 120 IDAIGQAYHSGDTITGSTVHYVDSGMDTGEIIEQRKCDIRPDDSKEQLEEKVKKLE 175
>sp|Q6GI12|PUR3_STAAR Phosphoribosylglycinamide formyltransferase
OS=Staphylococcus aureus (strain MRSA252) GN=purN PE=3 SV=1
Length = 188
Score = 68 bits (165), Expect = 1e-010
Identities = 48/176 (27%), Positives = 89/176 (50%), Gaps = 9/176 (5%)
Frame = +2
Query: 443 KIALLLSKQDHCLVEMLHKWQDGKLP-VDITCVISNHERAPNTHIMRFLQRHGIS-YHYL 616
KIA+ S ++ + GKL +++T + ++H+ N + ++H I Y
Sbjct: 3 KIAIFASGSGSNFENIVEHVESGKLENIEVTALYTDHQ---NAFCIDRAKKHDIPVYINE 59
Query: 617 PTTDQNK--IEEEIFELVKD--TDFIVLARYMQVLSGNFLKGYGKDVINIHHGLLPSFKG 784
P +K E+ + L+ + ++I+LA YM+++ + L + ++NIH LLP +KG
Sbjct: 60 PKQFGSKAAYEQHLVTLLNEDKVEWIILAGYMRLIGPDLLASFEGKILNIHPSLLPKYKG 119
Query: 785 RSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKSEDLE 952
QA+ +G + G+T H+V +D+G IIEQ + D+ +K + LE
Sbjct: 120 IDAIGQAYHSGDTITGSTVHYVDSGMDTGEIIEQRQCDIRPDDSKEQLEEKVKKLE 175
>sp|Q6GAE1|PUR3_STAAS Phosphoribosylglycinamide formyltransferase
OS=Staphylococcus aureus (strain MSSA476) GN=purN PE=3 SV=1
Length = 188
Score = 68 bits (164), Expect = 1e-010
Identities = 48/176 (27%), Positives = 89/176 (50%), Gaps = 9/176 (5%)
Frame = +2
Query: 443 KIALLLSKQDHCLVEMLHKWQDGKLP-VDITCVISNHERAPNTHIMRFLQRHGIS-YHYL 616
KIA+ S ++ + GKL +++T + ++H+ N + ++H I Y
Sbjct: 3 KIAIFASGSGSNFENIVEHVESGKLENIEVTALYTDHQ---NAFCIDRAKKHDIPVYINE 59
Query: 617 PTTDQNK--IEEEIFELVKD--TDFIVLARYMQVLSGNFLKGYGKDVINIHHGLLPSFKG 784
P +K E+ + L+ + ++I+LA YM+++ + L + ++NIH LLP +KG
Sbjct: 60 PKQFDSKAAYEQHLVSLLNEDKVEWIILAGYMRLIGPDLLASFEGKILNIHPSLLPKYKG 119
Query: 785 RSPAKQAFDAGVKLIGATTHFVTEELDSGPIIEQMVERVSHRDNLTSFVQKSEDLE 952
QA+ +G + G+T H+V +D+G IIEQ + D+ +K + LE
Sbjct: 120 IDAIGQAYHSGDTITGSTVHYVDCGMDTGEIIEQRQCDIRPDDSKEQLEEKVKKLE 175
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,370,385,861
Number of Sequences: 518415
Number of Extensions: 64370385861
Number of Successful Extensions: 454073489
Number of sequences better than 0.0: 0
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