BLASTX 7.6.2
Query= UN16280 /QuerySize=1309
(1308 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9S7U9|M2K2_ARATH Mitogen-activated protein kinase kinase 2 O... 670 7e-192
sp|Q94A06|M2K1_ARATH Mitogen-activated protein kinase kinase 1 O... 475 4e-133
sp|Q5QN75|M2K1_ORYSJ Mitogen-activated protein kinase kinase 1 O... 414 9e-115
sp|Q9FJV0|M2K6_ARATH Mitogen-activated protein kinase kinase 6 O... 404 1e-111
sp|Q55CL6|MP2K1_DICDI Dual specificity mitogen-activated protein... 222 6e-057
sp|P10506|BYR1_SCHPO Protein kinase byr1 OS=Schizosaccharomyces ... 214 2e-054
sp|Q90891|MP2K2_CHICK Dual specificity mitogen-activated protein... 201 1e-050
sp|P36507|MP2K2_HUMAN Dual specificity mitogen-activated protein... 200 3e-050
sp|Q1HG70|MP2K2_CANFA Dual specificity mitogen-activated protein... 199 4e-050
sp|Q90321|MP2K2_CYPCA Dual specificity mitogen-activated protein... 198 1e-049
sp|P36506|MP2K2_RAT Dual specificity mitogen-activated protein k... 197 2e-049
sp|Q63932|MP2K2_MOUSE Dual specificity mitogen-activated protein... 197 2e-049
sp|Q24324|DSOR1_DROME Dual specificity mitogen-activated protein... 196 5e-049
sp|Q02750|MP2K1_HUMAN Dual specificity mitogen-activated protein... 195 6e-049
sp|P29678|MP2K1_RABIT Dual specificity mitogen-activated protein... 195 6e-049
sp|Q91447|MP2K1_SERCA Dual specificity mitogen-activated protein... 195 6e-049
sp|Q05116|MP2K1_XENLA Dual specificity mitogen-activated protein... 195 6e-049
sp|P31938|MP2K1_MOUSE Dual specificity mitogen-activated protein... 195 8e-049
sp|Q01986|MP2K1_RAT Dual specificity mitogen-activated protein k... 195 8e-049
sp|Q63980|MP2K1_CRIGR Dual specificity mitogen-activated protein... 194 2e-048
>sp|Q9S7U9|M2K2_ARATH Mitogen-activated protein kinase kinase 2 OS=Arabidopsis
thaliana GN=MKK2 PE=1 SV=2
Length = 363
Score = 670 bits (1728), Expect = 7e-192
Identities = 335/363 (92%), Positives = 350/363 (96%), Gaps = 1/363 (0%)
Frame = +2
Query: 62 MKKGGFSNNLKLSIPPAGEQSITKFLTQSGTFKDGDLRVNKDGVRIVSQSEPEALSPIKP 241
MKKGGFSNNLKL+IP AGEQSITKFLTQSGTFKDGDLRVNKDGVRI+SQ EPE LSPIKP
Sbjct: 1 MKKGGFSNNLKLAIPVAGEQSITKFLTQSGTFKDGDLRVNKDGVRIISQLEPEVLSPIKP 60
Query: 242 ADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKSIAQELKIN 421
ADD+LSLSDLDMVK IGKGSSGVVQLVQHKWTGQFFALKVIQLN+DEAIRK+IAQELKIN
Sbjct: 61 ADDQLSLSDLDMVKVIGKGSSGVVQLVQHKWTGQFFALKVIQLNIDEAIRKAIAQELKIN 120
Query: 422 QSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIFKQVLQGLI 601
QSSQCP LVTSYQSFYDNGAISLILEYMDGGSL DFLKSVK IP+SYLSAIF+QVLQGLI
Sbjct: 121 QSSQCPNLVTSYQSFYDNGAISLILEYMDGGSLADFLKSVKAIPDSYLSAIFRQVLQGLI 180
Query: 602 YLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIV 781
YLHHD+HIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIV
Sbjct: 181 YLHHDRHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIV 240
Query: 782 GNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEETWSSVFELMEAIVDQPPPALPSESFS 961
GNKYGNKSDIWSLGLVVLECATGKFPY PP++EETW+SVFELMEAIVDQPPPALPS +FS
Sbjct: 241 GNKYGNKSDIWSLGLVVLECATGKFPYAPPNQEETWTSVFELMEAIVDQPPPALPSGNFS 300
Query: 962 PELSSFISTCLQKDPNSRSSARELMEHPFVKKYDNNSGINLASYFTNAGSPLATLKNLSG 1141
PELSSFISTCLQKDPNSRSSA+ELMEHPF+ KYD SGINLASYFT+AGSPLATL NLSG
Sbjct: 301 PELSSFISTCLQKDPNSRSSAKELMEHPFLNKYD-YSGINLASYFTDAGSPLATLGNLSG 359
Query: 1142 TFS 1150
TFS
Sbjct: 360 TFS 362
>sp|Q94A06|M2K1_ARATH Mitogen-activated protein kinase kinase 1 OS=Arabidopsis
thaliana GN=MKK1 PE=1 SV=2
Length = 354
Score = 475 bits (1221), Expect = 4e-133
Identities = 233/344 (67%), Positives = 287/344 (83%), Gaps = 2/344 (0%)
Frame = +2
Query: 95 LSIPPAGEQSITKFLTQSGTFKDGDLRVNKDGVRIVSQSEPEALSPIKPADDELSLSDLD 274
+ +PP EQSI+KFLTQSGTFKDGDLRVNKDG++ VS SEP A PI+P D++LSL+DL+
Sbjct: 11 ICLPPL-EQSISKFLTQSGTFKDGDLRVNKDGIQTVSLSEPGAPPPIEPLDNQLSLADLE 69
Query: 275 MVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKSIAQELKINQSSQCPYLVTS 454
++K IGKGSSG VQLV+HK T QFFALKVIQLN +E+ ++I+QEL+IN SSQCPYLV+
Sbjct: 70 VIKVIGKGSSGNVQLVKHKLTQQFFALKVIQLNTEESTCRAISQELRINLSSQCPYLVSC 129
Query: 455 YQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIFKQVLQGLIYLHHDKHIIHR 634
YQSFY NG +S+ILE+MDGGSL D LK V +PE+ LSAI K+VL+GL Y+HH++ IIHR
Sbjct: 130 YQSFYHNGLVSIILEFMDGGSLADLLKKVGKVPENMLSAICKRVLRGLCYIHHERRIIHR 189
Query: 635 DLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIVGNKYGNKSDIW 814
DLKPSNLLINHRGEVKITDFGVS ++T+T+ LAN+FVGTY YMSPERI G+ Y NKSDIW
Sbjct: 190 DLKPSNLLINHRGEVKITDFGVSKILTSTSSLANSFVGTYPYMSPERISGSLYSNKSDIW 249
Query: 815 SLGLVVLECATGKFPYLPPDEEETWSSVFELMEAIVDQPPPALPSESFSPELSSFISTCL 994
SLGLV+LECATGKFPY PP+ ++ WSSV+EL++AIV+ PPP PS FSPE SFIS C+
Sbjct: 250 SLGLVLLECATGKFPYTPPEHKKGWSSVYELVDAIVENPPPCAPSNLFSPEFCSFISQCV 309
Query: 995 QKDPNSRSSARELMEHPFVKKYDNNSGINLASYFTNAGSPLATL 1126
QKDP R SA+EL+EH FVK ++ +S NL++YFT+AGS + L
Sbjct: 310 QKDPRDRKSAKELLEHKFVKMFE-DSDTNLSAYFTDAGSLIPPL 352
>sp|Q5QN75|M2K1_ORYSJ Mitogen-activated protein kinase kinase 1 OS=Oryza sativa
subsp. japonica GN=MEK1 PE=1 SV=1
Length = 355
Score = 414 bits (1063), Expect = 9e-115
Identities = 198/329 (60%), Positives = 262/329 (79%), Gaps = 6/329 (1%)
Frame = +2
Query: 89 LKLSIPPAGEQSITKFLTQSGTFKDGDLRVNKDGVRIVSQ---SEPEALSPIKPADDELS 259
LKLS+ PA E + KFLT SGTFKDG+LR+N+ G++++S+ EP++ + +K D +LS
Sbjct: 10 LKLSV-PAQETPVDKFLTASGTFKDGELRLNQRGLQLISEETADEPQSTN-LKVEDVQLS 67
Query: 260 LSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKSIAQELKINQSSQCP 439
+ DL+M++ IGKGS G+VQLV+HKW G +ALK IQ+N+ EA+RK I QELKINQ++Q
Sbjct: 68 MDDLEMIQVIGKGSGGIVQLVRHKWVGTLYALKGIQMNIQEAVRKQIVQELKINQATQNA 127
Query: 440 YLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIFKQVLQGLIYLHHDK 619
++V +QSFY NG I L+LEYMD GSL D +K VKTI E YL+ + KQVL+GL+YLHH++
Sbjct: 128 HIVLCHQSFYHNGVIYLVLEYMDRGSLADIIKQVKTILEPYLAVLCKQVLEGLLYLHHER 187
Query: 620 HIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIVGNKYGN 799
H+IHRD+KPSNLL+N +GEVKITDFGVS V+ ++ G +TFVGTYNYM+PERI G+ Y
Sbjct: 188 HVIHRDIKPSNLLVNRKGEVKITDFGVSAVLASSMGQRDTFVGTYNYMAPERISGSSYDY 247
Query: 800 KSDIWSLGLVVLECATGKFPYLPPDEEETWSSVFELMEAIVDQPPPALPSESFSPELSSF 979
KSDIWSLGLV+LECA G+FPY+ P E E W S +EL+EAIVDQPPP+ P++ FSPE +F
Sbjct: 248 KSDIWSLGLVILECAIGRFPYI-PSEGEGWLSFYELLEAIVDQPPPSAPADQFSPEFCAF 306
Query: 980 ISTCLQKDPNSRSSARELMEHPFVKKYDN 1066
IS+C+QKDP R SA EL+ HPF+KK+++
Sbjct: 307 ISSCIQKDPAERMSASELLNHPFIKKFED 335
>sp|Q9FJV0|M2K6_ARATH Mitogen-activated protein kinase kinase 6 OS=Arabidopsis
thaliana GN=MKK6 PE=1 SV=1
Length = 356
Score = 404 bits (1036), Expect = 1e-111
Identities = 193/327 (59%), Positives = 250/327 (76%), Gaps = 2/327 (0%)
Frame = +2
Query: 89 LKLSIPPAGEQSITKFLTQSGTFKDGDLRVNKDGVRIVSQSEPEALSPIKPADDELSLSD 268
LKLS+ PA E I+ FLT SGTF DGD +N+ G+R+ S + S K D E++ D
Sbjct: 11 LKLSV-PAQESPISSFLTASGTFHDGDFLLNQKGLRLTSDEKQSRQSDSKELDFEITAED 69
Query: 269 LDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKSIAQELKINQ-SSQCPYL 445
L+ VK IGKGS GVVQLV+HKW G+FFA+KVIQ+N+ E IRK I QELKINQ SSQCP++
Sbjct: 70 LETVKVIGKGSGGVVQLVRHKWVGKFFAMKVIQMNIQEEIRKQIVQELKINQASSQCPHV 129
Query: 446 VTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIFKQVLQGLIYLHHDKHI 625
V Y SFY NGA SL+LEYMD GSL D ++ VKTI E YL+ + KQVL GL+YLH+++H+
Sbjct: 130 VVCYHSFYHNGAFSLVLEYMDRGSLADVIRQVKTILEPYLAVVCKQVLLGLVYLHNERHV 189
Query: 626 IHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIVGNKYGNKS 805
IHRD+KPSNLL+NH+GEVKI+DFGVS + ++ G +TFVGTYNYMSPERI G+ Y S
Sbjct: 190 IHRDIKPSNLLVNHKGEVKISDFGVSASLASSMGQRDTFVGTYNYMSPERISGSTYDYSS 249
Query: 806 DIWSLGLVVLECATGKFPYLPPDEEETWSSVFELMEAIVDQPPPALPSESFSPELSSFIS 985
DIWSLG+ VLECA G+FPYL ++++ S +EL+ AIV+ PPP PS+ FSPE SF+S
Sbjct: 250 DIWSLGMSVLECAIGRFPYLESEDQQNPPSFYELLAAIVENPPPTAPSDQFSPEFCSFVS 309
Query: 986 TCLQKDPNSRSSARELMEHPFVKKYDN 1066
C+QKDP +R+S+ +L+ HPF+KK+++
Sbjct: 310 ACIQKDPPARASSLDLLSHPFIKKFED 336
>sp|Q55CL6|MP2K1_DICDI Dual specificity mitogen-activated protein kinase kinase
1 OS=Dictyostelium discoideum GN=mekA PE=1 SV=1
Length = 660
Score = 222 bits (564), Expect = 6e-057
Identities = 109/211 (51%), Positives = 145/211 (68%), Gaps = 3/211 (1%)
Frame = +2
Query: 260 LSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKSIAQELKINQSSQCP 439
L DL +++ +G+G+ GVV+L H+ +G + ALKVI L++ E IRK I ELK + P
Sbjct: 289 LKDLKIIRVLGRGAGGVVKLAYHETSGTYIALKVITLDIQENIRKQIILELKTLHKTSYP 348
Query: 440 YLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIFKQVLQGLIYLHHDK 619
Y+V+ Y +FY G+I + LE+M+ GSL D +K TIPE L I QVLQGL+YLH
Sbjct: 349 YIVSFYDAFYTEGSIFIALEFMELGSLSDIMKKTSTIPEPVLGKIAFQVLQGLVYLHRKL 408
Query: 620 HIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIVGNKYGN 799
H+IHRD+KPSN+L+N++GE KI DFGVS + +T A T+VGT YMSPERI G Y
Sbjct: 409 HLIHRDIKPSNILVNNKGEAKIADFGVSGQLQHTLSKAVTWVGTVTYMSPERISGRSYSF 468
Query: 800 KSDIWSLGLVVLECATGKFPY---LPPDEEE 883
S+IWSLGL +LECA GKFPY LP +++
Sbjct: 469 DSEIWSLGLTILECAIGKFPYGSNLPHQQQQ 499
>sp|P10506|BYR1_SCHPO Protein kinase byr1 OS=Schizosaccharomyces pombe GN=byr1
PE=1 SV=1
Length = 340
Score = 214 bits (543), Expect = 2e-054
Identities = 115/269 (42%), Positives = 170/269 (63%), Gaps = 6/269 (2%)
Frame = +2
Query: 251 ELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKSIAQELKINQSS 430
+L S L++V+ +G+G+ G V LV+H+ F A K + + D ++K I +EL +
Sbjct: 60 DLDNSSLEVVRHLGEGNGGAVSLVKHR--NIFMARKTVYVGSDSKLQKQILRELGVLHHC 117
Query: 431 QCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIFKQVLQGLIYLH 610
+ PY+V Y +F ISL +EYMD GSL+ L+ IP L I +++GLIYL+
Sbjct: 118 RSPYIVGFYGAFQYKNNISLCMEYMDCGSLDAILREGGPIPLDILGKIINSMVKGLIYLY 177
Query: 611 HDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIVGNK 790
+ HIIHRDLKPSN+++N RGE+K+ DFGVS + N+ +A TFVGT YMSPERI G K
Sbjct: 178 NVLHIIHRDLKPSNVVVNSRGEIKLCDFGVSGELVNS--VAQTFVGTSTYMSPERIRGGK 235
Query: 791 YGNKSDIWSLGLVVLECATGKFPYLPPDEEETWSSVFELMEAIVDQPPPALPSESFSPEL 970
Y KSDIWSLG+ ++E AT + P+ + +++ + +L+ IV + PP LPS SF +L
Sbjct: 236 YTVKSDIWSLGISIIELATQELPWSFSNIDDS-IGILDLLHCIVQEEPPRLPS-SFPEDL 293
Query: 971 SSFISTCLQKDPNSRSSARELMEHPFVKK 1057
F+ CL KDP R+S ++L P+ ++
Sbjct: 294 RLFVDACLHKDPTLRASPQQLCAMPYFQQ 322
>sp|Q90891|MP2K2_CHICK Dual specificity mitogen-activated protein kinase kinase
2 OS=Gallus gallus GN=MAP2K2 PE=2 SV=1
Length = 398
Score = 201 bits (509), Expect = 1e-050
Identities = 102/222 (45%), Positives = 142/222 (63%), Gaps = 2/222 (0%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D + + +G G+ GVV VQHK +G A K+I L + AIR
Sbjct: 53 EAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHKPSGLIMARKLIHLEIKPAIRNQ 112
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y +FY +G IS+ +E+MDGGSL+ LK K IPE L +
Sbjct: 113 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVS 172
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
VL+GL YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 173 IAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 230
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEE 883
YMSPER+ G Y +SDIWS+GL ++E + G++P PPD +E
Sbjct: 231 YMSPERLQGTHYSVQSDIWSMGLSLVELSIGRYPIPPPDSKE 272
>sp|P36507|MP2K2_HUMAN Dual specificity mitogen-activated protein kinase kinase
2 OS=Homo sapiens GN=MAP2K2 PE=1 SV=1
Length = 400
Score = 200 bits (506), Expect = 3e-050
Identities = 101/222 (45%), Positives = 142/222 (63%), Gaps = 2/222 (0%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D + + +G G+ GVV VQH+ +G A K+I L + AIR
Sbjct: 55 EAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQ 114
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y +FY +G IS+ +E+MDGGSL+ LK K IPE L +
Sbjct: 115 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVS 174
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
VL+GL YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 175 IAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 232
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEE 883
YM+PER+ G Y +SDIWS+GL ++E A G++P PPD +E
Sbjct: 233 YMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE 274
>sp|Q1HG70|MP2K2_CANFA Dual specificity mitogen-activated protein kinase kinase
2 OS=Canis familiaris GN=MAP2K2 PE=2 SV=1
Length = 400
Score = 199 bits (505), Expect = 4e-050
Identities = 101/222 (45%), Positives = 142/222 (63%), Gaps = 2/222 (0%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D + + +G G+ GVV VQH+ +G A K+I L + AIR
Sbjct: 55 EAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQ 114
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y +FY +G IS+ +E+MDGGSL+ LK K IPE L +
Sbjct: 115 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVS 174
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
VL+GL YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 175 IAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 232
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEE 883
YMSPER+ G Y +SDIWS+GL ++E + G++P PPD +E
Sbjct: 233 YMSPERLQGTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKE 274
>sp|Q90321|MP2K2_CYPCA Dual specificity mitogen-activated protein kinase kinase
2 OS=Cyprinus carpio GN=map2k2 PE=2 SV=1
Length = 397
Score = 198 bits (502), Expect = 1e-049
Identities = 101/222 (45%), Positives = 142/222 (63%), Gaps = 2/222 (0%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D D + +G G+ GVV V+HK + A K+I L + AIR
Sbjct: 52 EAFLTQKAQVGELKDEDFDPICELGAGNGGVVHKVRHKPSRLVMARKLIHLEIKPAIRNQ 111
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y +FY +G IS+ +E+MDGGSL+ LK + IPE L +
Sbjct: 112 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEARRIPEEILGKVS 171
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
VL+GL+YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 172 IAVLRGLVYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 229
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEE 883
YMSPER+ G Y +SD+WS+GL ++E A G+FP PPD +E
Sbjct: 230 YMSPERLQGTHYSVQSDVWSMGLSLVELAIGRFPIPPPDAKE 271
>sp|P36506|MP2K2_RAT Dual specificity mitogen-activated protein kinase kinase 2
OS=Rattus norvegicus GN=Map2k2 PE=2 SV=1
Length = 400
Score = 197 bits (500), Expect = 2e-049
Identities = 100/226 (44%), Positives = 143/226 (63%), Gaps = 2/226 (0%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D + + +G G+ GVV +H+ +G A K+I L + A+R
Sbjct: 55 EAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQ 114
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y +FY +G IS+ +E+MDGGSL+ LK K IPE L +
Sbjct: 115 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVS 174
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
VL+GL YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 175 IAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 232
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEETWSS 895
YMSPER+ G Y +SDIWS+GL ++E A G++P PPD +E +S
Sbjct: 233 YMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEAS 278
>sp|Q63932|MP2K2_MOUSE Dual specificity mitogen-activated protein kinase kinase
2 OS=Mus musculus GN=Map2k2 PE=1 SV=1
Length = 401
Score = 197 bits (499), Expect = 2e-049
Identities = 100/226 (44%), Positives = 143/226 (63%), Gaps = 2/226 (0%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D + + +G G+ GVV +H+ +G A K+I L + A+R
Sbjct: 55 EAFLTQKAKVGELKDDDFERISELGAGNGGVVTKARHRPSGFIMARKLIHLEIKPAVRNQ 114
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y +FY +G IS+ +E+MDGGSL+ LK K IPE L +
Sbjct: 115 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEDILGKVS 174
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
VL+GL YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 175 IAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 232
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEETWSS 895
YMSPER+ G Y +SDIWS+GL ++E A G++P PPD +E +S
Sbjct: 233 YMSPERLQGTHYSVQSDIWSMGLSLVELAIGRYPIPPPDAKELEAS 278
>sp|Q24324|DSOR1_DROME Dual specificity mitogen-activated protein kinase kinase
dSOR1 OS=Drosophila melanogaster GN=Dsor1 PE=2 SV=2
Length = 396
Score = 196 bits (496), Expect = 5e-049
Identities = 106/217 (48%), Positives = 141/217 (64%), Gaps = 3/217 (1%)
Frame = +2
Query: 251 ELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKSIAQELKINQSS 430
ELS DL+ + +G G+ GVV V+H T A K+I L V AI+K I +ELK+
Sbjct: 81 ELSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHEC 140
Query: 431 QCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIFKQVLQGLIYLH 610
P++V Y +FY +G IS+ +EYMDGGSL+ LK IPES L I VL+GL YL
Sbjct: 141 NFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLR 200
Query: 611 HDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIVGNK 790
+ IIHRD+KPSN+L+N GE+KI DFGVS + ++ +AN+FVGT +YMSPER+ G
Sbjct: 201 DNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDS--MANSFVGTRSYMSPERLQGTH 258
Query: 791 YGNKSDIWSLGLVVLECATGKFPYLPPDEEETWSSVF 901
Y +SDIWSLGL ++E A G +P +PP T S+F
Sbjct: 259 YSVQSDIWSLGLSLVEMAIGMYP-IPPPNTATLESIF 294
>sp|Q02750|MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase
1 OS=Homo sapiens GN=MAP2K1 PE=1 SV=2
Length = 393
Score = 195 bits (495), Expect = 6e-049
Identities = 108/255 (42%), Positives = 149/255 (58%), Gaps = 14/255 (5%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D + + +G G+ GVV V HK +G A K+I L + AIR
Sbjct: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y +FY +G IS+ +E+MDGGSL+ LK IPE L +
Sbjct: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 170
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
V++GL YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 228
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEETWSSVFELM-------EA 916
YMSPER+ G Y +SDIWS+GL ++E A G++P PPD +E ELM +A
Sbjct: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE-----LELMFGCQVEGDA 283
Query: 917 IVDQPPPALPSESFS 961
P P P S
Sbjct: 284 AETPPRPRTPGRPLS 298
>sp|P29678|MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase
1 OS=Oryctolagus cuniculus GN=MAP2K1 PE=1 SV=2
Length = 393
Score = 195 bits (495), Expect = 6e-049
Identities = 108/255 (42%), Positives = 149/255 (58%), Gaps = 14/255 (5%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D + + +G G+ GVV V HK +G A K+I L + AIR
Sbjct: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y +FY +G IS+ +E+MDGGSL+ LK IPE L +
Sbjct: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 170
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
V++GL YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 228
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEETWSSVFELM-------EA 916
YMSPER+ G Y +SDIWS+GL ++E A G++P PPD +E ELM +A
Sbjct: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE-----LELMFGCQVEGDA 283
Query: 917 IVDQPPPALPSESFS 961
P P P S
Sbjct: 284 AETPPRPRTPGRPLS 298
>sp|Q91447|MP2K1_SERCA Dual specificity mitogen-activated protein kinase kinase
1 (Fragment) OS=Serinus canaria GN=MAP2K1 PE=2 SV=1
Length = 388
Score = 195 bits (495), Expect = 6e-049
Identities = 100/222 (45%), Positives = 140/222 (63%), Gaps = 2/222 (0%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D + + +G G+ GVV V HK +G A K+I L + AIR
Sbjct: 44 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQ 103
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y +FY +G IS+ +E+MDGGSL+ LK IPE L +
Sbjct: 104 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 163
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
V++GL YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 164 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 221
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEE 883
YMSPER+ G Y +SDIWS+GL ++E A G++P PPD +E
Sbjct: 222 YMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPIPPPDSKE 263
>sp|Q05116|MP2K1_XENLA Dual specificity mitogen-activated protein kinase kinase
1 OS=Xenopus laevis GN=map2k1 PE=1 SV=2
Length = 395
Score = 195 bits (495), Expect = 6e-049
Identities = 108/258 (41%), Positives = 151/258 (58%), Gaps = 11/258 (4%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D + V +G G+ GVV V HK T A K+I L + AIR
Sbjct: 51 EAFLTQKQKVGELKDDDFEKVSELGAGNGGVVFKVSHKPTSLIMARKLIHLEIKPAIRNQ 110
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y +FY +G IS+ +E+MDGGSL+ LK IPE L +
Sbjct: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGKIPEKILGKVS 170
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
V++GL YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 228
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEETWSSVF-------ELMEA 916
YMSPER+ G Y +SDIWS+GL ++E A G++P PPD +E +F
Sbjct: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAIGRYPIPPPDAKEL-ELIFGCSVERDPASSE 287
Query: 917 IVDQP-PPALPSESFSPE 967
+ +P PP P S+ P+
Sbjct: 288 LAPRPRPPGRPISSYGPD 305
>sp|P31938|MP2K1_MOUSE Dual specificity mitogen-activated protein kinase kinase
1 OS=Mus musculus GN=Map2k1 PE=1 SV=2
Length = 393
Score = 195 bits (494), Expect = 8e-049
Identities = 100/222 (45%), Positives = 140/222 (63%), Gaps = 2/222 (0%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D + + +G G+ GVV V HK +G A K+I L + AIR
Sbjct: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y +FY +G IS+ +E+MDGGSL+ LK IPE L +
Sbjct: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 170
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
V++GL YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 228
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEE 883
YMSPER+ G Y +SDIWS+GL ++E A G++P PPD +E
Sbjct: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270
>sp|Q01986|MP2K1_RAT Dual specificity mitogen-activated protein kinase kinase 1
OS=Rattus norvegicus GN=Map2k1 PE=1 SV=2
Length = 393
Score = 195 bits (494), Expect = 8e-049
Identities = 100/222 (45%), Positives = 140/222 (63%), Gaps = 2/222 (0%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D + + +G G+ GVV V HK +G A K+I L + AIR
Sbjct: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y +FY +G IS+ +E+MDGGSL+ LK IPE L +
Sbjct: 111 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 170
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
V++GL YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 228
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEE 883
YMSPER+ G Y +SDIWS+GL ++E A G++P PPD +E
Sbjct: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270
>sp|Q63980|MP2K1_CRIGR Dual specificity mitogen-activated protein kinase kinase
1 OS=Cricetulus griseus GN=MAP2K1 PE=1 SV=1
Length = 393
Score = 194 bits (491), Expect = 2e-048
Identities = 100/222 (45%), Positives = 139/222 (62%), Gaps = 2/222 (0%)
Frame = +2
Query: 218 EALSPIKPADDELSLSDLDMVKFIGKGSSGVVQLVQHKWTGQFFALKVIQLNVDEAIRKS 397
EA K EL D + + +G G+ GVV V HK +G A K+I L + AIR
Sbjct: 51 EAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ 110
Query: 398 IAQELKINQSSQCPYLVTSYQSFYDNGAISLILEYMDGGSLEDFLKSVKTIPESYLSAIF 577
I +EL++ PY+V Y FY +G IS+ +E+MDGGSL+ LK IPE L +
Sbjct: 111 IIRELQVLHECNSPYIVGFYGVFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVS 170
Query: 578 KQVLQGLIYLHHDKHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYN 757
V++GL YL I+HRD+KPSN+L+N RGE+K+ DFGVS + ++ +AN+FVGT +
Sbjct: 171 IAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRS 228
Query: 758 YMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYLPPDEEE 883
YMSPER+ G Y +SDIWS+GL ++E A G++P PPD +E
Sbjct: 229 YMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKE 270
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,946,960,590
Number of Sequences: 518415
Number of Extensions: 65946960590
Number of Successful Extensions: 470808347
Number of sequences better than 0.0: 0
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