BLASTX 7.6.2
Query= UN16634 /QuerySize=687
(686 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pong... 80 1e-014
sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Dani... 80 1e-014
sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo... 80 1e-014
sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gall... 75 3e-013
sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus ... 75 4e-013
sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member ... 69 3e-011
sp|Q9QYF1|RDH11_MOUSE Retinol dehydrogenase 11 OS=Mus musculus G... 67 7e-011
sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 OS=Bos taurus GN=... 66 2e-010
sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 OS=Mus musculus G... 66 2e-010
sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 OS=Homo sapiens G... 65 5e-010
sp|Q9VLU5|WWOX_DROME WW domain-containing oxidoreductase OS=Dros... 63 2e-009
sp|Q8TC12|RDH11_HUMAN Retinol dehydrogenase 11 OS=Homo sapiens G... 62 3e-009
sp|Q03326|OXIR_STRAT Probable oxidoreductase OS=Streptomyces ant... 57 1e-007
sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 OS=Homo sapiens G... 56 2e-007
sp|O74959|YJCD_SCHPO Uncharacterized oxidoreductase C736.13 OS=S... 54 8e-007
>sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pongo abelii
GN=WWOX PE=2 SV=1
Length = 414
Score = 80 bits (196), Expect = 1e-014
Identities = 39/102 (38%), Positives = 62/102 (60%)
Frame = +2
Query: 161 FGSASTAEEVTQGIDATHLAAIITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKT 340
+ ++TA E+ QG D T ++TG GIG ETA+ A GAHV++ RNM A +A +
Sbjct: 107 YDGSTTALEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVS 166
Query: 341 EILRQNANARVTLIHLDLSSFKSIKAFVRDFHALHLPLNILI 466
IL + A+V + LDL+ +S++ F F A ++PL++L+
Sbjct: 167 RILEEWHKAKVEAVTLDLALLRSVQHFAEAFKAKNVPLHVLV 208
>sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Danio rerio GN=wwox
PE=2 SV=1
Length = 412
Score = 80 bits (195), Expect = 1e-014
Identities = 41/105 (39%), Positives = 61/105 (58%)
Frame = +2
Query: 152 PSGFGSASTAEEVTQGIDATHLAAIITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEK 331
P + + A E+ G D + I+TG GIG ETAR A GAHV++ RN A K
Sbjct: 101 PKRYDGNTGALEILHGQDLSDKVIIVTGANSGIGFETARSFALHGAHVILACRNQSRASK 160
Query: 332 AKTEILRQNANARVTLIHLDLSSFKSIKAFVRDFHALHLPLNILI 466
A + I+ + + ARV ++ LDL+S +S++ F F A LPL++L+
Sbjct: 161 AASLIMGEWSKARVEVLPLDLASLRSVRQFAELFKATKLPLHVLV 205
>sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo sapiens
GN=WWOX PE=1 SV=1
Length = 414
Score = 80 bits (195), Expect = 1e-014
Identities = 39/102 (38%), Positives = 62/102 (60%)
Frame = +2
Query: 161 FGSASTAEEVTQGIDATHLAAIITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKT 340
+ ++TA E+ QG D T ++TG GIG ETA+ A GAHV++ RNM A +A +
Sbjct: 107 YDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVS 166
Query: 341 EILRQNANARVTLIHLDLSSFKSIKAFVRDFHALHLPLNILI 466
IL + A+V + LDL+ +S++ F F A ++PL++L+
Sbjct: 167 RILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLV 208
>sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gallus gallus
GN=WWOX PE=2 SV=2
Length = 414
Score = 75 bits (184), Expect = 3e-013
Identities = 40/98 (40%), Positives = 58/98 (59%)
Frame = +2
Query: 173 STAEEVTQGIDATHLAAIITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKTEILR 352
STA E+ QG D + IITG GIG ETA+ A GA+V++ RNM A IL
Sbjct: 111 STAMEILQGRDLSGKVIIITGANSGIGFETAKSFALHGAYVILACRNMSRGNDAVQRILE 170
Query: 353 QNANARVTLIHLDLSSFKSIKAFVRDFHALHLPLNILI 466
+ A+V + LDL+S +S++ F F + ++PL+IL+
Sbjct: 171 EWHKAKVEAMTLDLASLRSVQNFAEAFKSKNMPLHILV 208
>sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus musculus
GN=Wwox PE=1 SV=1
Length = 414
Score = 75 bits (183), Expect = 4e-013
Identities = 37/102 (36%), Positives = 61/102 (59%)
Frame = +2
Query: 161 FGSASTAEEVTQGIDATHLAAIITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKT 340
+ ++TA E+ QG D T ++TG GIG ETA+ A GAHV++ RN+ A +A +
Sbjct: 107 YDGSTTAMEILQGRDFTGKVVLVTGANSGIGFETAKSFALHGAHVILACRNLSRASEAVS 166
Query: 341 EILRQNANARVTLIHLDLSSFKSIKAFVRDFHALHLPLNILI 466
IL + A+V + LDL+ +S++ F F A ++ L++L+
Sbjct: 167 RILEEWHKAKVEAMTLDLAVLRSVQHFAEAFKAKNVSLHVLV 208
>sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member on chromosome X
OS=Homo sapiens GN=DHRSX PE=2 SV=2
Length = 330
Score = 69 bits (166), Expect = 3e-011
Identities = 33/83 (39%), Positives = 53/83 (63%)
Frame = +2
Query: 221 AIITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLIHLDLSS 400
AI+TGGT GIG TA+ +A+ G HV+I N A++ ++I + N +V ++ DL+S
Sbjct: 46 AIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLAS 105
Query: 401 FKSIKAFVRDFHALHLPLNILIS 469
SI+ FV+ F +PL++LI+
Sbjct: 106 MTSIRQFVQKFKMKKIPLHVLIN 128
>sp|Q9QYF1|RDH11_MOUSE Retinol dehydrogenase 11 OS=Mus musculus GN=Rdh11 PE=2
SV=2
Length = 316
Score = 67 bits (163), Expect = 7e-011
Identities = 38/93 (40%), Positives = 54/93 (58%)
Frame = +2
Query: 191 TQGIDATHLAAIITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKTEILRQNANAR 370
T + AI+TG GIG ETA+ +AQRGA V + R++ E A EI N++
Sbjct: 31 TSNVQLPGKVAIVTGANTGIGKETAKDLAQRGARVYLACRDVDKGELAAREIQAVTGNSQ 90
Query: 371 VTLIHLDLSSFKSIKAFVRDFHALHLPLNILIS 469
V + LDL+ KSI+AF +DF A L++LI+
Sbjct: 91 VFVRKLDLADTKSIRAFAKDFLAEEKHLHLLIN 123
>sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 OS=Bos taurus GN=RDH12 PE=2
SV=1
Length = 316
Score = 66 bits (159), Expect = 2e-010
Identities = 38/82 (46%), Positives = 50/82 (60%)
Frame = +2
Query: 224 IITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLIHLDLSSF 403
+ITG GIG ETAR +A+RGA V I R++ E A +EI N++V + LDLS
Sbjct: 43 VITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIQADTKNSQVLVRKLDLSDT 102
Query: 404 KSIKAFVRDFHALHLPLNILIS 469
KSI+AF F A L+ILI+
Sbjct: 103 KSIRAFAEGFLAEEKQLHILIN 124
>sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 OS=Mus musculus GN=Rdh12 PE=2
SV=1
Length = 316
Score = 66 bits (159), Expect = 2e-010
Identities = 39/93 (41%), Positives = 52/93 (55%)
Frame = +2
Query: 191 TQGIDATHLAAIITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKTEILRQNANAR 370
T + +ITG GIG ETAR +A+RGA V I R++ E A +EI N++
Sbjct: 32 TTNVQIPGKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIRADTKNSQ 91
Query: 371 VTLIHLDLSSFKSIKAFVRDFHALHLPLNILIS 469
V + LDLS KSI+AF F A L+ILI+
Sbjct: 92 VLVRKLDLSDTKSIRAFAERFLAEEKKLHILIN 124
>sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 OS=Homo sapiens GN=RDH12 PE=1
SV=3
Length = 316
Score = 65 bits (156), Expect = 5e-010
Identities = 38/82 (46%), Positives = 49/82 (59%)
Frame = +2
Query: 224 IITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLIHLDLSSF 403
+ITG GIG ETAR +A RGA V I R++ E A +EI N++V + LDLS
Sbjct: 43 VITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDT 102
Query: 404 KSIKAFVRDFHALHLPLNILIS 469
KSI+AF F A L+ILI+
Sbjct: 103 KSIRAFAEGFLAEEKQLHILIN 124
>sp|Q9VLU5|WWOX_DROME WW domain-containing oxidoreductase OS=Drosophila
melanogaster GN=Wwox PE=2 SV=1
Length = 409
Score = 63 bits (151), Expect = 2e-009
Identities = 37/92 (40%), Positives = 49/92 (53%), Gaps = 2/92 (2%)
Frame = +2
Query: 161 FGSASTAEEVTQGIDATHLAAIITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKT 340
F S STA +V G D A+ITG GIG ETAR +A G ++ RN AE A
Sbjct: 104 FDSCSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIE 163
Query: 341 EILRQN--ANARVTLIHLDLSSFKSIKAFVRD 430
I ++ A +R LDLSS +S++ FV +
Sbjct: 164 RIAQERPAARSRCRFAALDLSSLRSVQRFVEE 195
>sp|Q8TC12|RDH11_HUMAN Retinol dehydrogenase 11 OS=Homo sapiens GN=RDH11 PE=1
SV=2
Length = 318
Score = 62 bits (149), Expect = 3e-009
Identities = 34/82 (41%), Positives = 48/82 (58%)
Frame = +2
Query: 224 IITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLIHLDLSSF 403
++TG GIG ETA+ +AQRGA V + R++ E EI N +V + LDLS
Sbjct: 45 VVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDT 104
Query: 404 KSIKAFVRDFHALHLPLNILIS 469
KSI+AF + F A L++LI+
Sbjct: 105 KSIRAFAKGFLAEEKHLHVLIN 126
>sp|Q03326|OXIR_STRAT Probable oxidoreductase OS=Streptomyces antibioticus PE=3
SV=1
Length = 298
Score = 57 bits (135), Expect = 1e-007
Identities = 33/90 (36%), Positives = 47/90 (52%), Gaps = 3/90 (3%)
Frame = +2
Query: 200 IDATHLAAIITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTL 379
+D T A++TGG G+G ET R +A GA V + R AE E+ RVT
Sbjct: 1 MDLTGRRAVVTGGASGLGAETVRALAAAGAEVTVATRRPLSAEPLVQELAAAGGAGRVTA 60
Query: 380 IHLDLSSFKSIKAFVRDFHALHLPLNILIS 469
LDLS S+++F R + PL+IL++
Sbjct: 61 EALDLSDPASVESFARAWRG---PLDILVA 87
>sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1
SV=2
Length = 331
Score = 56 bits (133), Expect = 2e-007
Identities = 30/82 (36%), Positives = 46/82 (56%)
Frame = +2
Query: 224 IITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLIHLDLSSF 403
I+TG GIG +TA +A+RG ++++ R+M E A +I + N V HLDL+S
Sbjct: 42 IVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDLASL 101
Query: 404 KSIKAFVRDFHALHLPLNILIS 469
KSI+ F ++ILI+
Sbjct: 102 KSIREFAAKIIEEEERVDILIN 123
>sp|O74959|YJCD_SCHPO Uncharacterized oxidoreductase C736.13
OS=Schizosaccharomyces pombe GN=SPCC736.13 PE=2 SV=1
Length = 339
Score = 54 bits (128), Expect = 8e-007
Identities = 29/89 (32%), Positives = 49/89 (55%)
Frame = +2
Query: 203 DATHLAAIITGGTGGIGMETARVMAQRGAHVVIGARNMGVAEKAKTEILRQNANARVTLI 382
D T A++TG +GGIG TA +A++GA V + RN +K +I + ++++ +
Sbjct: 39 DLTGKVALVTGSSGGIGYVTALELARKGAKVYLAGRNEEKYQKVMKQIHDEVRHSKIRFL 98
Query: 383 HLDLSSFKSIKAFVRDFHALHLPLNILIS 469
LDL F+S+ F A L+IL++
Sbjct: 99 RLDLLDFESVYQAAESFIAKEEKLHILVN 127
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,472,851,095
Number of Sequences: 518415
Number of Extensions: 69472851095
Number of Successful Extensions: 496854919
Number of sequences better than 0.0: 0
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