BLASTX 7.6.2
Query= UN16778 /QuerySize=726
(725 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54DD7|UNC50_DICDI Protein unc-50 homolog OS=Dictyostelium di... 216 1e-055
sp|Q5U520|UN50B_XENLA Protein unc-50 homolog B OS=Xenopus laevis... 166 1e-040
sp|Q53HI1|UNC50_HUMAN Protein unc-50 homolog OS=Homo sapiens GN=... 163 1e-039
sp|Q3ZBG6|UNC50_BOVIN Protein unc-50 homolog OS=Bos taurus GN=UN... 161 7e-039
sp|O55227|UNC50_RAT Protein unc-50 homolog OS=Rattus norvegicus ... 160 9e-039
sp|Q9CQ61|UNC50_MOUSE Protein unc-50 homolog OS=Mus musculus GN=... 160 1e-038
sp|Q6DKM1|UN50A_XENLA Protein unc-50 homolog A OS=Xenopus laevis... 158 5e-038
sp|Q7ZUU1|UNC50_DANRE Protein unc-50 homolog OS=Danio rerio GN=u... 153 1e-036
sp|Q9VHN5|UNC50_DROME Protein unc-50 homolog OS=Drosophila melan... 148 5e-035
sp|P87155|MUG16_SCHPO Protein GMH1 homolog OS=Schizosaccharomyce... 147 1e-034
sp|Q10045|UNC50_CAEEL Protein unc-50 OS=Caenorhabditis elegans G... 144 7e-034
sp|P36125|GMH1_YEAST Protein GMH1 OS=Saccharomyces cerevisiae GN... 77 1e-013
>sp|Q54DD7|UNC50_DICDI Protein unc-50 homolog OS=Dictyostelium discoideum
GN=DDB_G0292320 PE=3 SV=1
Length = 261
Score = 216 bits (549), Expect = 1e-055
Identities = 100/207 (48%), Positives = 142/207 (68%), Gaps = 2/207 (0%)
Frame = +2
Query: 107 SRSRSSPSSSRANPMFLQYFRRIVKWQQMDVEYTFWQMLNLCTSPKVVYQHTKYHKQTKN 286
+R ++ S+SR + +YFRRI + QMD+EYTFW M LC +P VY+ T +HKQTKN
Sbjct: 15 TRDGTASSASRYRRLIPEYFRRIFHYPQMDIEYTFWIMFYLCFNPSRVYRVTSWHKQTKN 74
Query: 287 QWARDDPAFIVICSLLLIVATLAYCATYDH-SGSHAVVVVVSVFLTHFLITGAVIATCCW 463
QWARDDPAF VI + +A+++Y T+ S + + V+ F+ G +IAT W
Sbjct: 75 QWARDDPAFAVILVFFMAIASMSYAITFHFLSFLNVIKVMFWAVFVDFITVGLLIATIGW 134
Query: 464 FLTNSYLREEAPNSHVVEQRVEWLYTFDVHCNSFFPMFVLLYVVHYFLSPLLITHGFIAL 643
++TN +LR N H V+Q VEWLY FD+HCNSFFP+F++LYVV +FL P+L+++ A
Sbjct: 135 WVTNKFLRVSVHN-HSVDQSVEWLYAFDIHCNSFFPLFIILYVVQFFLLPILLSNSLFAA 193
Query: 644 LLSNLLFMVGASYYHYLNFLGYDVLPF 724
+LSN L+++G SYY+Y+ FLGY+ LPF
Sbjct: 194 ILSNTLYIIGFSYYYYVTFLGYNALPF 220
>sp|Q5U520|UN50B_XENLA Protein unc-50 homolog B OS=Xenopus laevis GN=unc50-b
PE=2 SV=1
Length = 259
Score = 166 bits (420), Expect = 1e-040
Identities = 87/222 (39%), Positives = 130/222 (58%), Gaps = 15/222 (6%)
Frame = +2
Query: 92 MLPTTSRSRSSPSSSRANP----------MFLQYFRRIVKWQQMDVEYTFWQMLNLCTSP 241
MLPTTS S SP + +P +Y RR+ ++QMD E+ WQML L TSP
Sbjct: 1 MLPTTSVSPRSPDNGILSPRDATRHTAGAKRYKYLRRLFHFKQMDFEFALWQMLYLFTSP 60
Query: 242 KVVYQHTKYHKQTKNQWARDDPAFIVICSLLLIVATLAYCATYDHSGSHAVVVVVSVFLT 421
+ VY++ Y KQTK+QWARDDPAF+V+ + L V+T+ + D S +++ V
Sbjct: 61 QKVYRNFHYRKQTKDQWARDDPAFLVLLGIWLCVSTVGFGFVLDMSFFETFTLLLWVVFI 120
Query: 422 HFLITGAVIATCCWFLTNSYLREEAPNSHVVEQRVEWLYTFDVHCNSFFPMFVLLYVVH- 598
+ G +IAT WF++N Y+ N + VEW YTFDVH N+F+P+ V+L+ +
Sbjct: 121 DCVGVGLLIATSMWFVSNKYM----VNRQGKDYDVEWGYTFDVHLNAFYPLLVILHFIQL 176
Query: 599 YFLSPLLITHGFIALLLSNLLFMVGASYYHYLNFLGYDVLPF 724
+F++ +++T FI + N L+++ YY Y+ FLGY LPF
Sbjct: 177 FFINHVILTGWFIGCFVGNTLWLIAIGYYIYITFLGYSALPF 218
>sp|Q53HI1|UNC50_HUMAN Protein unc-50 homolog OS=Homo sapiens GN=UNC50 PE=1
SV=2
Length = 259
Score = 163 bits (412), Expect = 1e-039
Identities = 79/190 (41%), Positives = 121/190 (63%), Gaps = 5/190 (2%)
Frame = +2
Query: 158 QYFRRIVKWQQMDVEYTFWQMLNLCTSPKVVYQHTKYHKQTKNQWARDDPAFIVICSLLL 337
+Y RR+ +++QMD E+ WQML L TSP+ VY++ Y KQTK+QWARDDPAF+V+ S+ L
Sbjct: 33 KYLRRLFRFRQMDFEFAAWQMLYLFTSPQRVYRNFHYRKQTKDQWARDDPAFLVLLSIWL 92
Query: 338 IVATLAYCATYDHSGSHAVVVVVSVFLTHFLITGAVIATCCWFLTNSYLREEAPNSHVVE 517
V+T+ + D + +++ V L + G +IAT WF++N YL + +
Sbjct: 93 CVSTIGFGFVLDMGFFETIKLLLWVVLIDCVGVGLLIATLMWFISNKYLVKRQSRDY--- 149
Query: 518 QRVEWLYTFDVHCNSFFPMFVLLYVVH-YFLSPLLITHGFIALLLSNLLFMVGASYYHYL 694
VEW Y FDVH N+F+P+ V+L+ + +F++ +++T FI L+ N L++V YY Y+
Sbjct: 150 -DVEWGYAFDVHLNAFYPLLVILHFIQLFFINHVILTDTFIGYLVGNTLWLVAVGYYIYV 208
Query: 695 NFLGYDVLPF 724
FLGY LPF
Sbjct: 209 TFLGYSALPF 218
>sp|Q3ZBG6|UNC50_BOVIN Protein unc-50 homolog OS=Bos taurus GN=UNC50 PE=2 SV=1
Length = 259
Score = 161 bits (405), Expect = 7e-039
Identities = 77/190 (40%), Positives = 120/190 (63%), Gaps = 5/190 (2%)
Frame = +2
Query: 158 QYFRRIVKWQQMDVEYTFWQMLNLCTSPKVVYQHTKYHKQTKNQWARDDPAFIVICSLLL 337
+Y RR+ +++QMD E+ WQML L TSP+ VY++ Y KQTK+QWARDDPAF+V+ S+ L
Sbjct: 33 KYLRRLFRFRQMDFEFAAWQMLYLFTSPQRVYRNFHYRKQTKDQWARDDPAFLVLLSIWL 92
Query: 338 IVATLAYCATYDHSGSHAVVVVVSVFLTHFLITGAVIATCCWFLTNSYLREEAPNSHVVE 517
V+T+ + D + +++ V + G +I+T WF++N YL + +
Sbjct: 93 CVSTIGFGFVLDMGFFETIKLLLWVVFIDCVGVGLLISTLMWFISNKYLVKRQSRDY--- 149
Query: 518 QRVEWLYTFDVHCNSFFPMFVLLYVVH-YFLSPLLITHGFIALLLSNLLFMVGASYYHYL 694
VEW Y FDVH N+F+P+ V+L+ + +F++ +++T FI L+ N L++V YY Y+
Sbjct: 150 -DVEWGYAFDVHLNAFYPLLVILHFIQLFFINHVILTDTFIGYLVGNTLWLVAVGYYIYV 208
Query: 695 NFLGYDVLPF 724
FLGY LPF
Sbjct: 209 TFLGYSALPF 218
>sp|O55227|UNC50_RAT Protein unc-50 homolog OS=Rattus norvegicus GN=Unc50 PE=1
SV=1
Length = 259
Score = 160 bits (404), Expect = 9e-039
Identities = 76/190 (40%), Positives = 120/190 (63%), Gaps = 5/190 (2%)
Frame = +2
Query: 158 QYFRRIVKWQQMDVEYTFWQMLNLCTSPKVVYQHTKYHKQTKNQWARDDPAFIVICSLLL 337
+Y RR+ +++QMD E+ WQML L TSP+ VY++ Y KQTK+QWARDDPAF+V+ S+ L
Sbjct: 33 KYLRRLFRFRQMDFEFAAWQMLYLFTSPQRVYRNFHYRKQTKDQWARDDPAFLVLLSIWL 92
Query: 338 IVATLAYCATYDHSGSHAVVVVVSVFLTHFLITGAVIATCCWFLTNSYLREEAPNSHVVE 517
V+T+ + D + +++ V + G +I+T WF++N YL + +
Sbjct: 93 CVSTIGFGFVLDMGFFETIKLLLWVVFIDCVGVGLLISTLMWFISNKYLVKRQSRDY--- 149
Query: 518 QRVEWLYTFDVHCNSFFPMFVLLYVVH-YFLSPLLITHGFIALLLSNLLFMVGASYYHYL 694
VEW Y FDVH N+F+P+ V+L+ + +F++ +++T FI L+ N L+++ YY Y+
Sbjct: 150 -DVEWGYAFDVHLNAFYPLLVILHFIQLFFINHVILTDTFIGYLVGNTLWLIAVGYYIYV 208
Query: 695 NFLGYDVLPF 724
FLGY LPF
Sbjct: 209 TFLGYSALPF 218
>sp|Q9CQ61|UNC50_MOUSE Protein unc-50 homolog OS=Mus musculus GN=Unc50 PE=2
SV=1
Length = 259
Score = 160 bits (403), Expect = 1e-038
Identities = 76/190 (40%), Positives = 120/190 (63%), Gaps = 5/190 (2%)
Frame = +2
Query: 158 QYFRRIVKWQQMDVEYTFWQMLNLCTSPKVVYQHTKYHKQTKNQWARDDPAFIVICSLLL 337
+Y RR+ +++QMD E+ WQML L TSP+ VY++ Y KQTK+QWARDDPAF+V+ S+ L
Sbjct: 33 KYLRRLFRFRQMDFEFAAWQMLYLFTSPQRVYRNFHYRKQTKDQWARDDPAFLVLLSIWL 92
Query: 338 IVATLAYCATYDHSGSHAVVVVVSVFLTHFLITGAVIATCCWFLTNSYLREEAPNSHVVE 517
V+T+ + D + +++ V + G +I+T WF++N YL + +
Sbjct: 93 CVSTIGFGFVLDMGFFETIKLLLWVVFIDCVGVGLLISTLMWFVSNKYLVKRQSRDY--- 149
Query: 518 QRVEWLYTFDVHCNSFFPMFVLLYVVH-YFLSPLLITHGFIALLLSNLLFMVGASYYHYL 694
VEW Y FDVH N+F+P+ V+L+ + +F++ +++T FI L+ N L+++ YY Y+
Sbjct: 150 -DVEWGYAFDVHLNAFYPLLVILHFIQLFFINHVILTDTFIGYLVGNTLWLIAVGYYIYV 208
Query: 695 NFLGYDVLPF 724
FLGY LPF
Sbjct: 209 TFLGYSALPF 218
>sp|Q6DKM1|UN50A_XENLA Protein unc-50 homolog A OS=Xenopus laevis GN=unc50-a
PE=2 SV=1
Length = 259
Score = 158 bits (398), Expect = 5e-038
Identities = 80/218 (36%), Positives = 129/218 (59%), Gaps = 10/218 (4%)
Frame = +2
Query: 74 RSREEKMLPTTSRSRSSPSSSRANPMFLQYFRRIVKWQQMDVEYTFWQMLNLCTSPKVVY 253
RS + +L +R + + R +Y RR+ ++QMD E+ WQML L TSP+ VY
Sbjct: 10 RSPDNGILSPREAARHTAGAKR-----YKYLRRLFHFKQMDFEFALWQMLYLFTSPQKVY 64
Query: 254 QHTKYHKQTKNQWARDDPAFIVICSLLLIVATLAYCATYDHSGSHAVVVVVSVFLTHFLI 433
++ Y KQTK+QWARDDPAF+V+ S+ L V+T+ + D S +++ V +
Sbjct: 65 RNFHYRKQTKDQWARDDPAFLVLLSIWLCVSTVGFGFVLDMSFFETFKLLLWVVFIDCVG 124
Query: 434 TGAVIATCCWFLTNSYLREEAPNSHVVEQRVEWLYTFDVHCNSFFPMFVLLYVVH-YFLS 610
G +IAT WF++N Y+ + + VEW YTFDVH N+F+P+ V+L+ + +F++
Sbjct: 125 VGLLIATLMWFVSNKYMVKRQGKDY----DVEWGYTFDVHLNAFYPLLVILHFIQLFFIN 180
Query: 611 PLLITHGFIALLLSNLLFMVGASYYHYLNFLGYDVLPF 724
++++ FI + N ++++ YY Y+ FLGY LPF
Sbjct: 181 HVILSGWFIGYFVGNTIWLIAIGYYIYITFLGYSALPF 218
>sp|Q7ZUU1|UNC50_DANRE Protein unc-50 homolog OS=Danio rerio GN=unc50 PE=2 SV=1
Length = 259
Score = 153 bits (386), Expect = 1e-036
Identities = 75/192 (39%), Positives = 121/192 (63%), Gaps = 7/192 (3%)
Frame = +2
Query: 158 QYFRRIVKWQQMDVEYTFWQMLNLCTSPKVVYQHTKYHKQTKNQWARDDPAFIVICSLLL 337
+Y RR++ ++QMD E+ WQML L TSP+ VY++ Y KQTK+QWARDDPAF+V+ S+ L
Sbjct: 31 KYLRRLLHFRQMDFEFAVWQMLYLFTSPQKVYRNFHYRKQTKDQWARDDPAFLVLLSIWL 90
Query: 338 IVATLAYCATYDHSGSHAVVVVVSVFLTHFLITGAVIATCCWFLTNSYLREEAPNSHVVE 517
V+T+ + D + +++ V + G +I+T WF+TN YL + PN +
Sbjct: 91 CVSTVGFGLVLDMGFVETLTLLLWVVFIDCIGVGLLISTLMWFVTNKYLMKH-PNR---D 146
Query: 518 QRVEWLYTFDVHCNSFFPMFVLLYVVH-YFLSPLLI--THGFIALLLSNLLFMVGASYYH 688
VEW Y FDVH N+F+P+ V+L+ + +F++ +++ + F+ + N ++++ YY
Sbjct: 147 YDVEWGYAFDVHLNAFYPLLVILHFLQLFFINHVVVISSDWFLGYFVGNTMWLIAIGYYV 206
Query: 689 YLNFLGYDVLPF 724
Y+ FLGY LPF
Sbjct: 207 YITFLGYSALPF 218
>sp|Q9VHN5|UNC50_DROME Protein unc-50 homolog OS=Drosophila melanogaster
GN=CG9773 PE=1 SV=1
Length = 275
Score = 148 bits (372), Expect = 5e-035
Identities = 81/216 (37%), Positives = 121/216 (56%), Gaps = 8/216 (3%)
Frame = +2
Query: 77 SREEKMLPTTSRSRSSPSSSRANPMFLQYFRRIVKWQQMDVEYTFWQMLNLCTSPKVVYQ 256
SR LP + R S A +Y RR++K+ QMD E+ WQML L +P+ VY+
Sbjct: 25 SRLHSPLPPPANHRRDCLS--ATTKSYKYLRRLLKFNQMDFEFALWQMLYLFVAPQKVYR 82
Query: 257 HTKYHKQTKNQWARDDPAFIVICSLLLIVATLAYCATYDHSGSHAVVVVVSVFLTHFLIT 436
+ Y KQTK+Q+ARDDPAF+V+ + L V +L + S ++ + V +
Sbjct: 83 NFNYRKQTKSQFARDDPAFLVLLVVCLCVTSLGFAYVLGLSFWQSISFIFYVVFVDCIFV 142
Query: 437 GAVIATCCWFLTNSYLREEAPNSHVVEQRVEWLYTFDVHCNSFFPMFVLLYVVHYFLSPL 616
G +IA+ W +TN YLR ++ +E +EW Y FDVH N+FFP +LL+ + F
Sbjct: 143 GIIIASFFWAVTNRYLR-----TNSLEPDIEWGYAFDVHLNAFFPPLMLLHFIQLFFYNW 197
Query: 617 LITH-GFIALLLSNLLFMVGASYYHYLNFLGYDVLP 721
LI+ FI+ L N +++G YY Y+ FLGY+ +P
Sbjct: 198 LISQTWFISRFLGNTFWLMGMGYYVYITFLGYNCIP 233
>sp|P87155|MUG16_SCHPO Protein GMH1 homolog OS=Schizosaccharomyces pombe
GN=mug16 PE=1 SV=1
Length = 235
Score = 147 bits (369), Expect = 1e-034
Identities = 70/188 (37%), Positives = 111/188 (59%), Gaps = 5/188 (2%)
Frame = +2
Query: 170 RIVKWQQMDVEYTFWQMLNLCTSPKVVYQHTKYHKQTKNQWARDDPAFIVICSLLLIVAT 349
R++K QMD E +W M NL +P+ VY+ KQ N++ R+D +FIV+ S +++++
Sbjct: 10 RLLKLSQMDFERAWWDMANLFRAPRRVYRSITLRKQNINRYGREDFSFIVLFSCMIVISA 69
Query: 350 LAYCATYDHSGSHAVVVVVSVFLTHFLITGAVIATCCWFLTNSYLREEAPNSHVV---EQ 520
L + Y ++ V + + F G ++AT +F+ +L + N ++ +
Sbjct: 70 LLWALFYMNTPKGYVTTITFMLFVDFGAVGVIMATMYYFIAKRFLMKS--NDTILSSTDY 127
Query: 521 RVEWLYTFDVHCNSFFPMFVLLYVVHYFLSPLLITHGFIALLLSNLLFMVGASYYHYLNF 700
++EW Y FDVHCNSFFP FVLLYV+ FL P++ FI+L + N L++V YY YL F
Sbjct: 128 QLEWNYCFDVHCNSFFPSFVLLYVIQLFLLPVITRDNFISLFMGNTLYLVALCYYSYLTF 187
Query: 701 LGYDVLPF 724
+GY +LPF
Sbjct: 188 IGYQILPF 195
>sp|Q10045|UNC50_CAEEL Protein unc-50 OS=Caenorhabditis elegans GN=unc-50 PE=2
SV=2
Length = 301
Score = 144 bits (362), Expect = 7e-034
Identities = 81/197 (41%), Positives = 120/197 (60%), Gaps = 23/197 (11%)
Frame = +2
Query: 158 QYFRRIVKWQQMDVEYTFWQMLNLCTSPKVVYQHTKYHKQTKNQWARDDPAFIVICSLLL 337
++ RR+V +QMD E+ WQML L P VY++ Y K+TK+Q+ARDDPAF+V+ +L L
Sbjct: 66 RFTRRLVHIRQMDFEFALWQMLYLLIQPSKVYKNFIYRKRTKDQFARDDPAFLVLLALSL 125
Query: 338 IVATLAYCATYDHSGSHAVVVVVSVFLTHFLIT--------GAVIATCCWFLTNSYLREE 493
+ +++ Y ++A+ + F T FL + G VIAT W+++N +LR+
Sbjct: 126 LFSSIFY--------AYALGLEKIGFFTFFLWSVFVDCIGVGVVIATVLWWVSNRFLRK- 176
Query: 494 APNSHVVEQRVEWLYTFDVHCNSFFPMFVLLYVVHYFLSPLLI-THGFIALLLSNLLFMV 670
V +Q VEW Y FDVH N+FFPM +LL+V+ L P LI + F+++LL N + +
Sbjct: 177 -----VRDQDVEWGYCFDVHLNAFFPMLILLHVIVPILYPTLIDSPAFLSILLGNTFWFL 231
Query: 671 GASYYHYLNFLGYDVLP 721
A YY Y+ FLGY LP
Sbjct: 232 AACYYVYITFLGYTALP 248
>sp|P36125|GMH1_YEAST Protein GMH1 OS=Saccharomyces cerevisiae GN=GMH1 PE=1
SV=1
Length = 273
Score = 77 bits (187), Expect = 1e-013
Identities = 40/114 (35%), Positives = 63/114 (55%), Gaps = 5/114 (4%)
Frame = +2
Query: 386 HAVVVVVSVFLTHFLITGAVIATCCWFLTN-SYLREEAPNSHVVEQRVEWLYTFDVHCNS 562
H +V + + F I G ++AT + L N S+ + ++ + V VEW Y FDVHCNS
Sbjct: 128 HFFKSLVMMVILDFFIFGFIMATIFYLLLNRSHFKFKSSQNSV----VEWAYCFDVHCNS 183
Query: 563 FFPMFVLLYVVHYFLSPLLITHGFIALLLSNLLFMVGASYYHYLNFLGYDVLPF 724
F + + LY + + L P++ +I+LL+ N L+ +Y L F GY+ LPF
Sbjct: 184 FLIILLCLYFIQFLLLPIINLQNWISLLIGNSLYCFAIGHYFILTFYGYNQLPF 237
Score = 55 bits (131), Expect = 4e-007
Identities = 24/65 (36%), Positives = 41/65 (63%), Gaps = 1/65 (1%)
Frame = +2
Query: 167 RRIVKW-QQMDVEYTFWQMLNLCTSPKVVYQHTKYHKQTKNQWARDDPAFIVICSLLLIV 343
RR+ K + +D+E W+M +L P+ Y+ Y +QTKNQWARDDP+F + L+ +
Sbjct: 43 RRLFKTPKNLDLETASWEMFHLIFHPRKAYRSIYYQRQTKNQWARDDPSFFIFQIALISL 102
Query: 344 ATLAY 358
+++ +
Sbjct: 103 SSIIW 107
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,472,851,095
Number of Sequences: 518415
Number of Extensions: 69472851095
Number of Successful Extensions: 496854919
Number of sequences better than 0.0: 0
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