BLASTX 7.6.2
Query= UN16821 /QuerySize=2070
(2069 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabi... 309 7e-083
sp|Q54TA1|DRKC_DICDI Probable serine/threonine-protein kinase dr... 171 3e-041
sp|Q55A09|Y9963_DICDI Probable serine/threonine-protein kinase D... 166 7e-040
sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kin... 161 2e-038
sp|Q54I36|PYK3_DICDI Dual specificity protein kinase pyk3 OS=Dic... 161 2e-038
sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kin... 160 4e-038
sp|Q54L00|LIMKA_DICDI Probable LIM domain-containing serine/thre... 159 1e-037
sp|A7J1T0|M313B_XENLA Mitogen-activated protein kinase kinase ki... 154 3e-036
sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase ki... 153 8e-036
sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase ki... 153 8e-036
sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kina... 152 1e-035
sp|Q95UN8|M3KSL_DROME Mitogen-activated protein kinase kinase ki... 151 3e-035
sp|A7J1T2|M313A_XENLA Mitogen-activated protein kinase kinase ki... 149 1e-034
sp|Q66L42|M3K10_MOUSE Mitogen-activated protein kinase kinase ki... 105 1e-021
sp|Q02779|M3K10_HUMAN Mitogen-activated protein kinase kinase ki... 105 2e-021
sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase ki... 102 1e-020
sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase ki... 102 1e-020
sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kina... 102 1e-020
sp|Q7T2V3|M3K10_XENLA Mitogen-activated protein kinase kinase ki... 94 3e-018
sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kin... 93 6e-018
>sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabidopsis thaliana
GN=HT1 PE=1 SV=1
Length = 390
Score = 309 bits (790), Expect = 7e-083
Identities = 162/355 (45%), Positives = 231/355 (65%), Gaps = 18/355 (5%)
Frame = +1
Query: 772 EGVKKSKKDT--GWSKLLNNGGGGGGRKVSASEAA----EEYRVDMSKLFFGLKFAHGLH 933
E ++K + D+ WS +L + V EA+ EE+ D+S+LF G KFA G H
Sbjct: 44 ETMEKKRFDSMESWSMILES------ENVETWEASKGEREEWTADLSQLFIGNKFASGAH 97
Query: 934 SRLYHGKYEDKPVAVKLITVPDDDENGCLGARLEKQFTKEVTLLPRLSHPNVIKFVGAYK 1113
SR+Y G Y+ + VAVK++ +P E A+LE+QF EV LL RL HPN+++F+ A K
Sbjct: 98 SRIYRGIYKQRAVAVKMVRIPTHKEE--TRAKLEQQFKSEVALLSRLFHPNIVQFIAACK 155
Query: 1114 DQPVYCVLTEYLPEGSLRSYLHKPENRSLPLKKLIEFALDISRGMEYIHSRHVVHWDLKP 1293
PVYC++TEY+ +G+LR YL+K E SL ++ ++ ALDISRGMEY+HS+ V+H DLK
Sbjct: 156 KPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQGVIHRDLKS 215
Query: 1294 ENVLIDEDLQLKIADFGIACEEEYCDMLADDPGTYRWMAPEMIRRKPHGRKADVYSFGLL 1473
N+L+++++++K+ADFG +C E C + GTYRWMAPEMI+ KP+ RK DVYSFG++
Sbjct: 216 NNLLLNDEMRVKVADFGTSCLETQCREAKGNMGTYRWMAPEMIKEKPYTRKVDVYSFGIV 275
Query: 1474 LWEMVAGATPYEDMNPIQAAFAVVDKNLRPVIPGDCPAAMKALIERCWSVAPDKRPDFWQ 1653
LWE+ P++ M P+QAAFAV +KN RP +P C A+ LI+RCWS P KRPDF
Sbjct: 276 LWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLIKRCWSENPSKRPDFSN 335
Query: 1654 IVKVLEQFEASLEREGNLDLASNKICKDTRKGLKHWIQKLGPVHGGSSGIGGSAV 1818
IV VLE+++ + +EG L L S+ T+K + ++ G V SS S+V
Sbjct: 336 IVAVLEKYDECV-KEG-LPLTSHASLTKTKKAILDHLK--GCVTSISSPFSSSSV 386
>sp|Q54TA1|DRKC_DICDI Probable serine/threonine-protein kinase drkC
OS=Dictyostelium discoideum GN=drkC PE=3 SV=1
Length = 749
Score = 171 bits (431), Expect = 3e-041
Identities = 96/268 (35%), Positives = 152/268 (56%), Gaps = 11/268 (4%)
Frame = +1
Query: 883 VDMSKLFFGLKFAHGLHSRLYHGKYEDKPVAVKLITVPDDDENGCLGARLEKQFTKEVTL 1062
+D+S++ + G + ++ G + VA+K + ++D+ L + +E T+
Sbjct: 486 IDISEIVVQNRIGRGSCAEVFTGTWRGIIVAIKKAKLLNEDDEDFL-----NELAQEATI 540
Query: 1063 LPRLSHPNVIKFVGAYKDQPVYCVLTEYLPEGSLRSYLHKPENRSLPLKKLIEFALDISR 1242
+ +L HPN+ +F+G + P ++ EY+P GSL LH P + SL ++ ALDI++
Sbjct: 541 MSQLRHPNICQFLGTCNNPPEILIVMEYMPLGSLYRILHDP-SISLDWPRMKSMALDIAK 599
Query: 1243 GMEYIH--SRHVVHWDLKPENVLIDEDLQLKIADFGIACE-EEYCD-MLADDP-GTYRWM 1407
GM Y+H V+H DLK N+L+DE ++KI+DFG++ +++ D A P GT W
Sbjct: 600 GMNYLHCCDPIVIHRDLKSHNLLVDEHYRVKISDFGLSTRFKKHLDKKTAMTPVGTPCWT 659
Query: 1408 APEMIRRKPHGRKADVYSFGLLLWEMVAGATPYEDMNPIQAAFAVVDKNLRPVIPGDCPA 1587
APE++R P+ KADV+SF ++LWE+V PY+ M Q +V LRP++P A
Sbjct: 660 APEVLRNDPYTEKADVFSFAIVLWEIVTREDPYQGMPTFQIVISVGQHKLRPIVPPQVSA 719
Query: 1588 AMKALIERCWSVAPDKRPDFWQIVKVLE 1671
LI CWS P +RP F +IVK LE
Sbjct: 720 PFTRLITECWSEDPQQRPSFQEIVKRLE 747
>sp|Q55A09|Y9963_DICDI Probable serine/threonine-protein kinase DDB_G0272254
OS=Dictyostelium discoideum GN=DDB_G0272254 PE=3 SV=1
Length = 1331
Score = 166 bits (419), Expect = 7e-040
Identities = 84/216 (38%), Positives = 131/216 (60%), Gaps = 8/216 (3%)
Frame = +1
Query: 1036 KQFTKEVTLLPRLSHPNVIKFVGAYKDQPVYCVLTEYLPEGSLRSYLH-KPENRSLPLK- 1209
++F EV LL L HPN++ G Y P+ C++ E+LP G+L +H KP + +K
Sbjct: 1115 QEFKAEVELLGSLQHPNLVTCYG-YSLNPM-CIVMEFLPSGNLFELIHSKPSEQQQSIKL 1172
Query: 1210 ---KLIEFALDISRGMEYIHSRHVVHWDLKPENVLIDEDLQLKIADFGIACEEEYCDMLA 1380
++ A DI+RGM+++H+R+++H DLK N+L+D+ +KIAD GIA E + +
Sbjct: 1173 DSTLILAIAFDIARGMQHLHTRNIIHRDLKSSNLLMDKHFNIKIADLGIARETSFTQTMT 1232
Query: 1381 DDPGTYRWMAPEMIRRKPHGRKADVYSFGLLLWEMVAGATPYEDMNPIQAAFAVVDKNLR 1560
GT W APE++R + + +KADVYS+ ++L+E++ G PY+ + P+ A V K LR
Sbjct: 1233 -TIGTVAWTAPEILRHESYNQKADVYSYAIVLYELLTGEEPYQGIPPMNAGILVASKGLR 1291
Query: 1561 PVIPGDCPAAMKALIERCWSVAPDKRPDFWQIVKVL 1668
P +P +C K L+ CWS P+KRP F +I L
Sbjct: 1292 PELPDNCDPNWKKLVVWCWSEDPNKRPSFEEITNYL 1327
>sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kinase MLT OS=Mus
musculus GN=Mltk PE=1 SV=1
Length = 802
Score = 161 bits (407), Expect = 2e-038
Identities = 83/223 (37%), Positives = 128/223 (57%), Gaps = 8/223 (3%)
Frame = +1
Query: 1048 KEVTLLPRLSHPNVIKFVGAYKDQPVYCVLTEYLPEGSLRSYLHKPENRSLPLKKLIEFA 1227
KE +L LSH N+I+F G + P Y ++TEY GSL Y++ + + ++ ++ +A
Sbjct: 52 KEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWA 111
Query: 1228 LDISRGMEYIHSR---HVVHWDLKPENVLIDEDLQLKIADFGIACEEEYCDMLADDPGTY 1398
D+++GM Y+H V+H DLK NV+I D LKI DFG + + ++ GT+
Sbjct: 112 TDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMS-LVGTF 170
Query: 1399 RWMAPEMIRRKPHGRKADVYSFGLLLWEMVAGATPYEDMNPIQAAFAVVDKNLRPVIPGD 1578
WMAPE+I+ P D YS+G++LWEM+ P++ + +Q A+ VV+KN R IP
Sbjct: 171 PWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 230
Query: 1579 CPAAMKALIERCWSVAPDKRPDFWQIVKVLEQFEASLEREGNL 1707
CP + L+ +CW KRP F QI+ +LE S+ + NL
Sbjct: 231 CPRSFAELLHQCWEADAKKRPSFKQIISILE----SMSNDTNL 269
>sp|Q54I36|PYK3_DICDI Dual specificity protein kinase pyk3 OS=Dictyostelium
discoideum GN=pyk3 PE=1 SV=1
Length = 1338
Score = 161 bits (407), Expect = 2e-038
Identities = 85/222 (38%), Positives = 132/222 (59%), Gaps = 4/222 (1%)
Frame = +1
Query: 1033 EKQFTKEVTLLPRLSHPNVIKFVGAYKDQPVYCVLTEYLPEGSLRSYLHKPENRSLPLKK 1212
+++F KEV+ L + HPNV+ F+GA D P C+ TEYL GSL LH + + PL
Sbjct: 1094 DEKFIKEVSSLIKSHHPNVVTFMGACIDPP--CIFTEYLQGGSLYDVLHIQKIKLNPL-M 1150
Query: 1213 LIEFALDISRGMEYIHSRHVVHWDLKPENVLIDEDLQLKIADFGIACEEEYCDMLADDPG 1392
+ + D+S GME++HS ++H DL +N+L+DE +KIADFG+A DM
Sbjct: 1151 MYKMIHDLSLGMEHLHSIQMLHRDLTSKNILLDEFKNIKIADFGLATTLS-DDMTLSGIT 1209
Query: 1393 TYRWMAPEMIRRKPHGRKADVYSFGLLLWEMVAGATPYEDMNPIQAAFAVVDKNLRPVIP 1572
RW +PE+ + + K DVYSFGL+++E+ G P+E ++ +A +N RP IP
Sbjct: 1210 NPRWRSPELTKGLVYNEKVDVYSFGLVVYEIYTGKIPFEGLDGTASAAKAAFENYRPAIP 1269
Query: 1573 GDCPAAMKALIERCWSVAPDKRPDFWQIVKVLEQFEASLERE 1698
DCP +++ LI +CW+ P +RP F +I+ LE ++ ++
Sbjct: 1270 PDCPVSLRKLITKCWASDPSQRPSFTEILTELETMKSKFIKQ 1311
>sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kinase MLT OS=Homo
sapiens GN=MLTK PE=1 SV=2
Length = 800
Score = 160 bits (404), Expect = 4e-038
Identities = 80/211 (37%), Positives = 122/211 (57%), Gaps = 4/211 (1%)
Frame = +1
Query: 1048 KEVTLLPRLSHPNVIKFVGAYKDQPVYCVLTEYLPEGSLRSYLHKPENRSLPLKKLIEFA 1227
KE +L LSH N+I+F G + P Y ++TEY GSL Y++ + + + ++ +A
Sbjct: 52 KEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWA 111
Query: 1228 LDISRGMEYIHSR---HVVHWDLKPENVLIDEDLQLKIADFGIACEEEYCDMLADDPGTY 1398
D+++GM Y+H V+H DLK NV+I D LKI DFG + + ++ GT+
Sbjct: 112 TDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMS-LVGTF 170
Query: 1399 RWMAPEMIRRKPHGRKADVYSFGLLLWEMVAGATPYEDMNPIQAAFAVVDKNLRPVIPGD 1578
WMAPE+I+ P D YS+G++LWEM+ P++ + +Q A+ VV+KN R IP
Sbjct: 171 PWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSS 230
Query: 1579 CPAAMKALIERCWSVAPDKRPDFWQIVKVLE 1671
CP + L+ +CW KRP F QI+ +LE
Sbjct: 231 CPRSFAELLHQCWEADAKKRPSFKQIISILE 261
>sp|Q54L00|LIMKA_DICDI Probable LIM domain-containing serine/threonine-protein
kinase DDB_G0287001 OS=Dictyostelium discoideum GN=DDB_G0287001 PE=3
SV=1
Length = 650
Score = 159 bits (400), Expect = 1e-037
Identities = 95/270 (35%), Positives = 144/270 (53%), Gaps = 12/270 (4%)
Frame = +1
Query: 904 FGLKFAHGLHSRLYHGKYEDKPVAVKLITVPDDDENGCLGARLEKQFTKEVTLLPRL--S 1077
FG A G ++Y G Y+ + VA+K+ + EN C ++F +EVT++ +
Sbjct: 388 FGDVIASGASGKVYKGIYKGRDVAIKVYS----SENFCFNI---EEFDREVTIMSLIDSD 440
Query: 1078 HPNVIKFVGAYKDQPVYCV-LTEYLPEGSLRSYLHKPENRSLPLKKLIEFALDISRGMEY 1254
HPN +F GA K Y ++E + GSLR L E + L + A DI+ M++
Sbjct: 441 HPNFTRFYGANKQNKKYLFHVSELVKSGSLRDLLLDKE-KPLAYFTQLSIASDIANAMKH 499
Query: 1255 IHSRHVVHWDLKPENVLIDEDLQLKIADFGIACEEEYCDMLADDPGTYRWMAPEMIRRKP 1434
+HS V+H DLK NVLI ED K+ DFG + + + + GT +M+PE+ +
Sbjct: 500 LHSIGVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKQMTLNLGTSCYMSPELFKGNG 559
Query: 1435 HGRKADVYSFGLLLWEMVAGATPYEDMNPIQAAFAVVDKNLRPVIPGDCPAAMKALIERC 1614
+ DVY+FG++LWE++A PYE++N +V K RP IP DCP+ LI+ C
Sbjct: 560 YDETCDVYAFGIVLWEIIARKEPYENINSWSIP-VLVAKGERPTIPADCPSEYSKLIKAC 618
Query: 1615 WSVAPDKRPDFWQIVKVLEQFEASLEREGN 1704
W+ P KRP F +I L++ SL + N
Sbjct: 619 WTDKPKKRPSFKEICDTLKKISESLTLKRN 648
>sp|A7J1T0|M313B_XENLA Mitogen-activated protein kinase kinase kinase 13-B
OS=Xenopus laevis GN=map3k13-b PE=2 SV=1
Length = 961
Score = 154 bits (388), Expect = 3e-036
Identities = 78/215 (36%), Positives = 117/215 (54%), Gaps = 2/215 (0%)
Frame = +1
Query: 1027 RLEKQFTKEVTLLPRLSHPNVIKFVGAYKDQPVYCVLTEYLPEGSLRSYLHKPENRSLPL 1206
++ +Q ++ L +L HPN+I F G P YC+L EY +G L L R +
Sbjct: 199 KVREQKETDIKHLRKLKHPNIIAFKGVCTQAPCYCILMEYCAQGQLYEVLR--AGRKVTP 256
Query: 1207 KKLIEFALDISRGMEYIHSRHVVHWDLKPENVLIDEDLQLKIADFGIACEEEYCDMLADD 1386
K L+E++ I+ GM Y+H ++H DLK NVL+ +KI+DFG + E
Sbjct: 257 KLLVEWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHADTVKISDFGTSKELSDKSTKMSF 316
Query: 1387 PGTYRWMAPEMIRRKPHGRKADVYSFGLLLWEMVAGATPYEDMNPIQAAFAVVDKNLRPV 1566
GT WMAPE+IR +P K D++SFG+LLWE++ G PY+D++ + V +L
Sbjct: 317 AGTVAWMAPEVIRNEPVSEKVDIWSFGVLLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP 376
Query: 1567 IPGDCPAAMKALIERCWSVAPDKRPDFWQIVKVLE 1671
+P CP K L+++ W P RP F QI+ L+
Sbjct: 377 VPSTCPDGFKILMKQTWQSKPRNRPSFRQILMHLD 411
>sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 OS=Homo
sapiens GN=MAP3K12 PE=1 SV=2
Length = 859
Score = 153 bits (384), Expect = 8e-036
Identities = 75/207 (36%), Positives = 115/207 (55%), Gaps = 2/207 (0%)
Frame = +1
Query: 1051 EVTLLPRLSHPNVIKFVGAYKDQPVYCVLTEYLPEGSLRSYLHKPENRSLPLKKLIEFAL 1230
++ L +L HPN+I F G P YC+L E+ +G L L R + L+++++
Sbjct: 161 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLR--AGRPVTPSLLVDWSM 218
Query: 1231 DISRGMEYIHSRHVVHWDLKPENVLIDEDLQLKIADFGIACEEEYCDMLADDPGTYRWMA 1410
I+ GM Y+H ++H DLK N+LI D +KI+DFG + E GT WMA
Sbjct: 219 GIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMA 278
Query: 1411 PEMIRRKPHGRKADVYSFGLLLWEMVAGATPYEDMNPIQAAFAVVDKNLRPVIPGDCPAA 1590
PE+IR +P K D++SFG++LWE++ G PY+D++ + V +L +P CP
Sbjct: 279 PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDG 338
Query: 1591 MKALIERCWSVAPDKRPDFWQIVKVLE 1671
K L+ +CW+ P RP F QI+ L+
Sbjct: 339 FKILLRQCWNSKPRNRPSFRQILLHLD 365
>sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase kinase 12 OS=Mus
musculus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 153 bits (384), Expect = 8e-036
Identities = 75/207 (36%), Positives = 115/207 (55%), Gaps = 2/207 (0%)
Frame = +1
Query: 1051 EVTLLPRLSHPNVIKFVGAYKDQPVYCVLTEYLPEGSLRSYLHKPENRSLPLKKLIEFAL 1230
++ L +L HPN+I F G P YC+L E+ +G L L R + L+++++
Sbjct: 194 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLR--AGRPVTPSLLVDWSM 251
Query: 1231 DISRGMEYIHSRHVVHWDLKPENVLIDEDLQLKIADFGIACEEEYCDMLADDPGTYRWMA 1410
I+ GM Y+H ++H DLK N+LI D +KI+DFG + E GT WMA
Sbjct: 252 GIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMA 311
Query: 1411 PEMIRRKPHGRKADVYSFGLLLWEMVAGATPYEDMNPIQAAFAVVDKNLRPVIPGDCPAA 1590
PE+IR +P K D++SFG++LWE++ G PY+D++ + V +L +P CP
Sbjct: 312 PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDG 371
Query: 1591 MKALIERCWSVAPDKRPDFWQIVKVLE 1671
K L+ +CW+ P RP F QI+ L+
Sbjct: 372 FKILLRQCWNSKPRNRPSFRQILLHLD 398
>sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kinase 12 OS=Rattus
norvegicus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 152 bits (383), Expect = 1e-035
Identities = 75/207 (36%), Positives = 115/207 (55%), Gaps = 2/207 (0%)
Frame = +1
Query: 1051 EVTLLPRLSHPNVIKFVGAYKDQPVYCVLTEYLPEGSLRSYLHKPENRSLPLKKLIEFAL 1230
++ L +L HPN+I F G P YC+L E+ +G L L R + L+++++
Sbjct: 194 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLR--AGRPVTPSLLVDWSM 251
Query: 1231 DISRGMEYIHSRHVVHWDLKPENVLIDEDLQLKIADFGIACEEEYCDMLADDPGTYRWMA 1410
I+ GM Y+H ++H DLK N+LI D +KI+DFG + E GT WMA
Sbjct: 252 GIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMA 311
Query: 1411 PEMIRRKPHGRKADVYSFGLLLWEMVAGATPYEDMNPIQAAFAVVDKNLRPVIPGDCPAA 1590
PE+IR +P K D++SFG++LWE++ G PY+D++ + V +L +P CP
Sbjct: 312 PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDG 371
Query: 1591 MKALIERCWSVAPDKRPDFWQIVKVLE 1671
K L+ +CW+ P RP F QI+ L+
Sbjct: 372 FKILLRQCWNRKPRNRPSFRQILLHLD 398
>sp|Q95UN8|M3KSL_DROME Mitogen-activated protein kinase kinase kinase
OS=Drosophila melanogaster GN=slpr PE=1 SV=1
Length = 1161
Score = 151 bits (379), Expect = 3e-035
Identities = 93/289 (32%), Positives = 144/289 (49%), Gaps = 21/289 (7%)
Frame = +1
Query: 853 SASEAAEEYRVDMSKLFFGLKFAHGLHSRLYHGKYEDKPVAVKLITVPDDDENGCLGARL 1032
SA + + ++ ++L G +++ G Y+ + VA+K+ +D+ R+
Sbjct: 127 SAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDM----QRM 182
Query: 1033 EKQFTKEVTLLPRLSHPNVIKFVGAYKDQPVYCVLTEYLPEGSLRSYLHKPENRSLPLKK 1212
+E L L H N+ G + + C++ EY GSL L +P
Sbjct: 183 RDNVLQEAKLFWALKHENIAALRGVCLNTKL-CLVMEYARGGSLNRIL----AGKIPPDV 237
Query: 1213 LIEFALDISRGMEYIHSR---HVVHWDLKPENVLIDEDLQ--------LKIADFGIACEE 1359
L+ +A+ I+RGM Y+H+ ++H DLK NVLI E ++ LKI DFG+A E
Sbjct: 238 LVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLA-RE 296
Query: 1360 EYCDMLADDPGTYRWMAPEMIRRKPHGRKADVYSFGLLLWEMVAGATPYEDMNPIQAAFA 1539
Y GTY WM PE+I + + +DV+S+G+LLWE++ G TPY+ +P+ A+
Sbjct: 297 MYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYG 356
Query: 1540 VVDKNLRPVIPGDCPAAMKALIERCWSVAPDKRPDFWQIVKVLEQFEAS 1686
V L IP CP AL++ CW P KRP F +I+K LE S
Sbjct: 357 VAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACS 405
>sp|A7J1T2|M313A_XENLA Mitogen-activated protein kinase kinase kinase 13-A
OS=Xenopus laevis GN=map3k13-a PE=2 SV=1
Length = 961
Score = 149 bits (374), Expect = 1e-034
Identities = 75/215 (34%), Positives = 116/215 (53%), Gaps = 2/215 (0%)
Frame = +1
Query: 1027 RLEKQFTKEVTLLPRLSHPNVIKFVGAYKDQPVYCVLTEYLPEGSLRSYLHKPENRSLPL 1206
++ +Q ++ L +L HPN+I F G P YC++ EY G L L R +
Sbjct: 197 KVREQKETDIKHLRKLKHPNIIAFKGVCTQAPCYCLIMEYCAHGQLYEVLR--AGRKVSP 254
Query: 1207 KKLIEFALDISRGMEYIHSRHVVHWDLKPENVLIDEDLQLKIADFGIACEEEYCDMLADD 1386
+ L++++ I+ GM Y+H ++H DLK NVL+ +KI+DFG + E
Sbjct: 255 RLLVDWSNGIASGMNYLHLHKIIHRDLKSPNVLVTHTDTVKISDFGTSKELSDKSTKMSF 314
Query: 1387 PGTYRWMAPEMIRRKPHGRKADVYSFGLLLWEMVAGATPYEDMNPIQAAFAVVDKNLRPV 1566
GT WMAPE+IR +P K D++SFG+LLWE++ G PY+D++ + V +L
Sbjct: 315 AGTVAWMAPEVIRNEPVSEKVDIWSFGVLLWELLTGEIPYKDVDSSAIIWGVGSNSLHLP 374
Query: 1567 IPGDCPAAMKALIERCWSVAPDKRPDFWQIVKVLE 1671
+P CP K L+++ W P RP F QI+ L+
Sbjct: 375 VPSTCPDGFKILMKQTWHSKPRNRPSFRQILMHLD 409
>sp|Q66L42|M3K10_MOUSE Mitogen-activated protein kinase kinase kinase 10 OS=Mus
musculus GN=Map3k10 PE=2 SV=2
Length = 940
Score = 105 bits (261), Expect = 1e-021
Identities = 53/124 (42%), Positives = 70/124 (56%), Gaps = 1/124 (0%)
Frame = +1
Query: 1315 DLQLKIADFGIACEEEYCDMLADDPGTYRWMAPEMIRRKPHGRKADVYSFGLLLWEMVAG 1494
D LKI DFG+A E ++ GTY WMAPE+IR + +DV+SFG+LLWE++ G
Sbjct: 241 DTVLKITDFGLAREWHKTTKMS-AAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTG 299
Query: 1495 ATPYEDMNPIQAAFAVVDKNLRPVIPGDCPAAMKALIERCWSVAPDKRPDFWQIVKVLEQ 1674
PY +++ + A+ V L IP CP L+E CW P RPDF I+K LE
Sbjct: 300 EVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQLEV 359
Query: 1675 FEAS 1686
E S
Sbjct: 360 IEQS 363
>sp|Q02779|M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 OS=Homo
sapiens GN=MAP3K10 PE=1 SV=3
Length = 954
Score = 105 bits (260), Expect = 2e-021
Identities = 53/124 (42%), Positives = 70/124 (56%), Gaps = 1/124 (0%)
Frame = +1
Query: 1315 DLQLKIADFGIACEEEYCDMLADDPGTYRWMAPEMIRRKPHGRKADVYSFGLLLWEMVAG 1494
D LKI DFG+A E ++ GTY WMAPE+IR + +DV+SFG+LLWE++ G
Sbjct: 241 DTVLKITDFGLAREWHKTTKMS-AAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTG 299
Query: 1495 ATPYEDMNPIQAAFAVVDKNLRPVIPGDCPAAMKALIERCWSVAPDKRPDFWQIVKVLEQ 1674
PY +++ + A+ V L IP CP L+E CW P RPDF I+K LE
Sbjct: 300 EVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEV 359
Query: 1675 FEAS 1686
E S
Sbjct: 360 IEQS 363
>sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 OS=Homo
sapiens GN=MAP3K11 PE=1 SV=1
Length = 847
Score = 102 bits (254), Expect = 1e-020
Identities = 52/129 (40%), Positives = 73/129 (56%), Gaps = 1/129 (0%)
Frame = +1
Query: 1312 EDLQLKIADFGIACEEEYCDMLADDPGTYRWMAPEMIRRKPHGRKADVYSFGLLLWEMVA 1491
E LKI DFG+A E ++ GTY WMAPE+I+ + +DV+SFG+LLWE++
Sbjct: 259 EHKTLKITDFGLAREWHKTTQMS-AAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLT 317
Query: 1492 GATPYEDMNPIQAAFAVVDKNLRPVIPGDCPAAMKALIERCWSVAPDKRPDFWQIVKVLE 1671
G PY ++ + A+ V L IP CP L+ CW+ P +RPDF I++ LE
Sbjct: 318 GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLE 377
Query: 1672 QFEASLERE 1698
EA + RE
Sbjct: 378 ALEAQVLRE 386
>sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase kinase 11 OS=Mus
musculus GN=Map3k11 PE=1 SV=1
Length = 850
Score = 102 bits (254), Expect = 1e-020
Identities = 52/129 (40%), Positives = 73/129 (56%), Gaps = 1/129 (0%)
Frame = +1
Query: 1312 EDLQLKIADFGIACEEEYCDMLADDPGTYRWMAPEMIRRKPHGRKADVYSFGLLLWEMVA 1491
E LKI DFG+A E ++ GTY WMAPE+I+ + +DV+SFG+LLWE++
Sbjct: 260 EHKTLKITDFGLAREWHKTTQMS-AAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLT 318
Query: 1492 GATPYEDMNPIQAAFAVVDKNLRPVIPGDCPAAMKALIERCWSVAPDKRPDFWQIVKVLE 1671
G PY ++ + A+ V L IP CP L+ CW+ P +RPDF I++ LE
Sbjct: 319 GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLE 378
Query: 1672 QFEASLERE 1698
EA + RE
Sbjct: 379 ALEAQVLRE 387
>sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kinase 11 OS=Rattus
norvegicus GN=Map3k11 PE=2 SV=1
Length = 850
Score = 102 bits (254), Expect = 1e-020
Identities = 52/129 (40%), Positives = 73/129 (56%), Gaps = 1/129 (0%)
Frame = +1
Query: 1312 EDLQLKIADFGIACEEEYCDMLADDPGTYRWMAPEMIRRKPHGRKADVYSFGLLLWEMVA 1491
E LKI DFG+A E ++ GTY WMAPE+I+ + +DV+SFG+LLWE++
Sbjct: 260 EHKTLKITDFGLAREWHKTTQMS-AAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLT 318
Query: 1492 GATPYEDMNPIQAAFAVVDKNLRPVIPGDCPAAMKALIERCWSVAPDKRPDFWQIVKVLE 1671
G PY ++ + A+ V L IP CP L+ CW+ P +RPDF I++ LE
Sbjct: 319 GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLE 378
Query: 1672 QFEASLERE 1698
EA + RE
Sbjct: 379 ALEAQVLRE 387
>sp|Q7T2V3|M3K10_XENLA Mitogen-activated protein kinase kinase kinase 10
OS=Xenopus laevis GN=map3k10 PE=1 SV=1
Length = 1005
Score = 94 bits (233), Expect = 3e-018
Identities = 47/121 (38%), Positives = 67/121 (55%), Gaps = 1/121 (0%)
Frame = +1
Query: 1324 LKIADFGIACEEEYCDMLADDPGTYRWMAPEMIRRKPHGRKADVYSFGLLLWEMVAGATP 1503
L I DFG+A E + ++ GTY WMAPE+IR + +DV+SFG+LLWE++ G P
Sbjct: 264 LNITDFGLAREWQKTTKMS-AAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVP 322
Query: 1504 YEDMNPIQAAFAVVDKNLRPVIPGDCPAAMKALIERCWSVAPDKRPDFWQIVKVLEQFEA 1683
Y +++ + A+ V L IP CP ++E CW P RP F I++ L E
Sbjct: 323 YREIDALAVAYGVAMNKLTLPIPSTCPEPFVRILEACWDPDPHSRPTFSCILEQLTTIEQ 382
Query: 1684 S 1686
S
Sbjct: 383 S 383
>sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 OS=Homo
sapiens GN=MAP3K9 PE=1 SV=3
Length = 1104
Score = 93 bits (230), Expect = 6e-018
Identities = 47/121 (38%), Positives = 66/121 (54%), Gaps = 1/121 (0%)
Frame = +1
Query: 1324 LKIADFGIACEEEYCDMLADDPGTYRWMAPEMIRRKPHGRKADVYSFGLLLWEMVAGATP 1503
LKI DFG+A E ++ GTY WMAPE+IR + +DV+S+G+LLWE++ G P
Sbjct: 290 LKITDFGLAREWHRTTKMS-AAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVP 348
Query: 1504 YEDMNPIQAAFAVVDKNLRPVIPGDCPAAMKALIERCWSVAPDKRPDFWQIVKVLEQFEA 1683
+ ++ + A+ V L IP CP L+E CW+ P RP F I+ L E
Sbjct: 349 FRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEE 408
Query: 1684 S 1686
S
Sbjct: 409 S 409
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,472,851,095
Number of Sequences: 518415
Number of Extensions: 69472851095
Number of Successful Extensions: 496854919
Number of sequences better than 0.0: 0
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