BLASTX 7.6.2
Query= UN16899 /QuerySize=1207
(1206 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O80585|MTHR2_ARATH Methylenetetrahydrofolate reductase 2 OS=A... 484 6e-136
sp|Q9SE60|MTHR1_ARATH Methylenetetrahydrofolate reductase 1 OS=A... 443 2e-123
sp|Q75HE6|MTHR_ORYSJ Probable methylenetetrahydrofolate reductas... 383 2e-105
sp|Q9SE94|MTHR1_MAIZE Methylenetetrahydrofolate reductase 1 OS=Z... 380 1e-104
sp|P42898|MTHR_HUMAN Methylenetetrahydrofolate reductase OS=Homo... 203 2e-051
sp|Q9WU20|MTHR_MOUSE Methylenetetrahydrofolate reductase OS=Mus ... 203 4e-051
sp|Q60HE5|MTHR_MACFA Methylenetetrahydrofolate reductase OS=Maca... 202 5e-051
sp|Q5I598|MTHR_BOVIN Methylenetetrahydrofolate reductase OS=Bos ... 200 2e-050
sp|Q10258|MTHR1_SCHPO Methylenetetrahydrofolate reductase 1 OS=S... 196 4e-049
sp|Q17693|MTHR_CAEEL Probable methylenetetrahydrofolate reductas... 171 1e-041
sp|O74927|MTHR2_SCHPO Methylenetetrahydrofolate reductase 2 OS=S... 163 3e-039
sp|P46151|MTHR1_YEAST Methylenetetrahydrofolate reductase 1 OS=S... 163 4e-039
sp|P53128|MTHR2_YEAST Methylenetetrahydrofolate reductase 2 OS=S... 158 1e-037
>sp|O80585|MTHR2_ARATH Methylenetetrahydrofolate reductase 2 OS=Arabidopsis
thaliana GN=MTHFR2 PE=1 SV=2
Length = 594
Score = 484 bits (1245), Expect = 6e-136
Identities = 232/250 (92%), Positives = 241/250 (96%)
Frame = +2
Query: 257 GMGGLPQGRWGDSRSASYGALTDHQFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLG 436
G PQGRWGDSRSASYGAL+DHQFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLG
Sbjct: 345 GWEDFPQGRWGDSRSASYGALSDHQFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLG 404
Query: 437 NLKSSPWSELDGLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGPGGYV 616
NLKSSPWSELDGLQPET+IINEQL+K+NSKGFLTINSQPSVNAERSDS TVGWGGP GYV
Sbjct: 405 NLKSSPWSELDGLQPETRIINEQLIKVNSKGFLTINSQPSVNAERSDSPTVGWGGPVGYV 464
Query: 617 YQKAYLEFFCSKEKLDAVVEKCKALPSITYIAVNKGDNWVSNTAQSDVNAVTWGVFPAKE 796
YQKAYLEFFCSKEKLDAVVEKCKALPSITY+AVNKG+ WVSNTAQ+DVNAVTWGVFPAKE
Sbjct: 465 YQKAYLEFFCSKEKLDAVVEKCKALPSITYMAVNKGEQWVSNTAQADVNAVTWGVFPAKE 524
Query: 797 IIQPTIVDPASFKVWKDEAFETWSRSWANLYPESDPSRNLLEEVKNSYYLVSLVENDYIN 976
IIQPTIVDPASF VWKDEAFETWSRSWANLYPE+DPSRNLLEEVKNSYYLVSLVENDYIN
Sbjct: 525 IIQPTIVDPASFNVWKDEAFETWSRSWANLYPEADPSRNLLEEVKNSYYLVSLVENDYIN 584
Query: 977 GNIFTVFADL 1006
G+IF VFADL
Sbjct: 585 GDIFAVFADL 594
Score = 183 bits (462), Expect = 4e-045
Identities = 86/89 (96%), Positives = 88/89 (98%)
Frame = +3
Query: 3 KAYGIHLGTEMCRKILAHGTKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPAN 182
KAYGIHLGTEMC+K+LAHG KSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPAN
Sbjct: 260 KAYGIHLGTEMCKKMLAHGVKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPAN 319
Query: 183 VFRTKEDVRPIFWANRPKSYISRTKGWED 269
VFRTKEDVRPIFWANRPKSYISRTKGWED
Sbjct: 320 VFRTKEDVRPIFWANRPKSYISRTKGWED 348
>sp|Q9SE60|MTHR1_ARATH Methylenetetrahydrofolate reductase 1 OS=Arabidopsis
thaliana GN=MTHFR1 PE=1 SV=1
Length = 592
Score = 443 bits (1137), Expect = 2e-123
Identities = 206/248 (83%), Positives = 226/248 (91%)
Frame = +2
Query: 257 GMGGLPQGRWGDSRSASYGALTDHQFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLG 436
G P GRWGDS SA+Y L+D+QF+RP+ RDKKLQQEWVVPLKS+ED+QEKFKELC+G
Sbjct: 345 GWNDFPHGRWGDSHSAAYSTLSDYQFARPKGRDKKLQQEWVVPLKSIEDVQEKFKELCIG 404
Query: 437 NLKSSPWSELDGLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGPGGYV 616
NLKSSPWSELDGLQPETKIINEQL KINS GFLTINSQPSVNA +SDS +GWGGPGGYV
Sbjct: 405 NLKSSPWSELDGLQPETKIINEQLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYV 464
Query: 617 YQKAYLEFFCSKEKLDAVVEKCKALPSITYIAVNKGDNWVSNTAQSDVNAVTWGVFPAKE 796
YQKAYLEFFCSK+KLD +VEK KA PSITY+AVNK +NWVSNT +SDVNAVTWGVFPAKE
Sbjct: 465 YQKAYLEFFCSKDKLDTLVEKSKAFPSITYMAVNKSENWVSNTGESDVNAVTWGVFPAKE 524
Query: 797 IIQPTIVDPASFKVWKDEAFETWSRSWANLYPESDPSRNLLEEVKNSYYLVSLVENDYIN 976
+IQPTIVDPASFKVWKDEAFE WSRSWANLYPE DPSR LLEEVKNSYYLVSLV+N+YIN
Sbjct: 525 VIQPTIVDPASFKVWKDEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNNYIN 584
Query: 977 GNIFTVFA 1000
G+IF+VFA
Sbjct: 585 GDIFSVFA 592
Score = 169 bits (428), Expect = 3e-041
Identities = 81/103 (78%), Positives = 88/103 (85%), Gaps = 1/103 (0%)
Frame = +3
Query: 3 KAYGIHLGTEMCRKILAHGTKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPAN 182
KAYGIH TEMC+KILAHG SLHLYTLN++KSA+ ILMNLG+IDESKISRSLPWRRPAN
Sbjct: 260 KAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNLGLIDESKISRSLPWRRPAN 319
Query: 183 VFRTKEDVRPIFWANRPKSYISRTKGWED-SHKAGGVIHAVLH 308
VFRTKEDVRPIFWANRPKSYISRTKGW D H G H+ +
Sbjct: 320 VFRTKEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDSHSAAY 362
>sp|Q75HE6|MTHR_ORYSJ Probable methylenetetrahydrofolate reductase OS=Oryza
sativa subsp. japonica GN=Os03g0815200 PE=2 SV=1
Length = 594
Score = 383 bits (982), Expect = 2e-105
Identities = 178/250 (71%), Positives = 207/250 (82%)
Frame = +2
Query: 257 GMGGLPQGRWGDSRSASYGALTDHQFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLG 436
G P GRWGDSR+ SYGALTD+QF+RPR R KKLQ+EW VP+KSVEDI E+F C G
Sbjct: 345 GWDQYPHGRWGDSRNPSYGALTDYQFTRPRGRGKKLQEEWAVPVKSVEDINERFMNFCQG 404
Query: 437 NLKSSPWSELDGLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGPGGYV 616
L SSPWSELDGLQPETKII++QLVKIN KGFLTINSQP+VN ERSDS++VGWGGPGGYV
Sbjct: 405 KLTSSPWSELDGLQPETKIIDDQLVKINQKGFLTINSQPAVNGERSDSTSVGWGGPGGYV 464
Query: 617 YQKAYLEFFCSKEKLDAVVEKCKALPSITYIAVNKGDNWVSNTAQSDVNAVTWGVFPAKE 796
YQKAYLEFFCSKEKLD ++EK KA PS+TYIAVNK SN + VNAVTWGVFP KE
Sbjct: 465 YQKAYLEFFCSKEKLDQLIEKSKAFPSLTYIAVNKDGESFSNIPTNAVNAVTWGVFPGKE 524
Query: 797 IIQPTIVDPASFKVWKDEAFETWSRSWANLYPESDPSRNLLEEVKNSYYLVSLVENDYIN 976
I+QPT+VD ASF VWKDEAFE WS+ WA L+PE D SR +L++V+ SY+LVSLV+NDYIN
Sbjct: 525 IVQPTVVDSASFMVWKDEAFEIWSKGWACLFPEGDSSREILDKVQKSYFLVSLVDNDYIN 584
Query: 977 GNIFTVFADL 1006
G++F F ++
Sbjct: 585 GDLFAAFKEI 594
Score = 162 bits (408), Expect = 7e-039
Identities = 76/88 (86%), Positives = 81/88 (92%)
Frame = +3
Query: 3 KAYGIHLGTEMCRKILAHGTKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPAN 182
KAYGIHLGTEMC+KILA G K+LHLYTLNMEKSAL ILMNLG+I+ESKISRSLPWR P N
Sbjct: 260 KAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALGILMNLGLIEESKISRSLPWRPPTN 319
Query: 183 VFRTKEDVRPIFWANRPKSYISRTKGWE 266
VFR KEDVRPIFWANRPKSYISRT GW+
Sbjct: 320 VFRVKEDVRPIFWANRPKSYISRTLGWD 347
>sp|Q9SE94|MTHR1_MAIZE Methylenetetrahydrofolate reductase 1 OS=Zea mays PE=2
SV=1
Length = 593
Score = 380 bits (975), Expect = 1e-104
Identities = 177/247 (71%), Positives = 202/247 (81%)
Frame = +2
Query: 257 GMGGLPQGRWGDSRSASYGALTDHQFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLG 436
G P GRWGDSR+ SYGALTDHQF+RPR R KKLQ+EW VPLKSVEDI E+F C G
Sbjct: 345 GWDQYPHGRWGDSRNPSYGALTDHQFTRPRGRGKKLQEEWAVPLKSVEDISERFTNFCQG 404
Query: 437 NLKSSPWSELDGLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGPGGYV 616
L SSPWSELDGLQPETKII++QLV IN KGFLTINSQP+VN E+SDS TVGWGGPGGYV
Sbjct: 405 KLTSSPWSELDGLQPETKIIDDQLVNINQKGFLTINSQPAVNGEKSDSPTVGWGGPGGYV 464
Query: 617 YQKAYLEFFCSKEKLDAVVEKCKALPSITYIAVNKGDNWVSNTAQSDVNAVTWGVFPAKE 796
YQKAYLEFFC+KEKLD ++EK KA PS+TYIAVNK SN + + VNAVTWGVFP KE
Sbjct: 465 YQKAYLEFFCAKEKLDQLIEKIKAFPSLTYIAVNKDGETFSNISPNAVNAVTWGVFPGKE 524
Query: 797 IIQPTIVDPASFKVWKDEAFETWSRSWANLYPESDPSRNLLEEVKNSYYLVSLVENDYIN 976
IIQPT+VD ASF VWKDEAFE W+R W ++PE D SR LLE+V+ +YYLVSLV+NDY+
Sbjct: 525 IIQPTVVDHASFMVWKDEAFEIWTRGWGCMFPEGDSSRELLEKVQKTYYLVSLVDNDYVQ 584
Query: 977 GNIFTVF 997
G++F F
Sbjct: 585 GDLFAAF 591
Score = 149 bits (375), Expect = 5e-035
Identities = 67/88 (76%), Positives = 77/88 (87%)
Frame = +3
Query: 3 KAYGIHLGTEMCRKILAHGTKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPAN 182
+ YGIHLGTEMC+KILA G K+LHLYTLNM+KSA+ ILMNLG+I+ESK+SR LPWR N
Sbjct: 260 RQYGIHLGTEMCKKILATGIKTLHLYTLNMDKSAIGILMNLGLIEESKVSRPLPWRPATN 319
Query: 183 VFRTKEDVRPIFWANRPKSYISRTKGWE 266
VFR KEDVRPIFWANRPKSY+ RT GW+
Sbjct: 320 VFRVKEDVRPIFWANRPKSYLKRTLGWD 347
>sp|P42898|MTHR_HUMAN Methylenetetrahydrofolate reductase OS=Homo sapiens
GN=MTHFR PE=1 SV=3
Length = 656
Score = 203 bits (516), Expect = 2e-051
Identities = 103/244 (42%), Positives = 153/244 (62%), Gaps = 13/244 (5%)
Frame = +2
Query: 272 PQGRWGDSRSASYGALTDHQ--FSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLG--- 436
P GRWG+S S ++G L D+ + + ++ ++L + W L S E + E F G
Sbjct: 385 PNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLYLSGEPN 444
Query: 437 ----NLKSSPWSELDGLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGP 604
+ PW++ + L ET ++ E+L+++N +G LTINSQP++N + S VGWG
Sbjct: 445 RNGHKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPIVGWGPS 503
Query: 605 GGYVYQKAYLEFFCSKEKLDAVVEKCKALP-SITYIAVN-KGDNWVSNTAQSDVNAVTWG 778
GGYV+QKAYLEFF S+E +A+++ K + Y VN KG+N ++N + NAVTWG
Sbjct: 504 GGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGEN-ITNAPELQPNAVTWG 562
Query: 779 VFPAKEIIQPTIVDPASFKVWKDEAFETWSRSWANLYPESDPSRNLLEEVKNSYYLVSLV 958
+FP +EIIQPT+VDP SF WKDEAF W W LY E PSR +++ + ++Y+LV+LV
Sbjct: 563 IFPGREIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYFLVNLV 622
Query: 959 ENDY 970
+ND+
Sbjct: 623 DNDF 626
Score = 87 bits (214), Expect = 2e-016
Identities = 44/88 (50%), Positives = 56/88 (63%), Gaps = 2/88 (2%)
Frame = +3
Query: 9 YGIHLGTEMCRKILAHG-TKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPANV 185
YGI L +C+++LA G LH YTLN E + +L LGM E R LPW A+
Sbjct: 297 YGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHP 355
Query: 186 FRTKEDVRPIFWANRPKSYISRTKGWED 269
R +EDVRPIFWA+RPKSYI RT+ W++
Sbjct: 356 KRREEDVRPIFWASRPKSYIYRTQEWDE 383
>sp|Q9WU20|MTHR_MOUSE Methylenetetrahydrofolate reductase OS=Mus musculus
GN=Mthfr PE=2 SV=1
Length = 654
Score = 203 bits (514), Expect = 4e-051
Identities = 102/244 (41%), Positives = 155/244 (63%), Gaps = 13/244 (5%)
Frame = +2
Query: 272 PQGRWGDSRSASYGALTDHQ--FSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLG--- 436
P GRWG+S S ++G L D+ + + ++ ++L + W L S E + E F+ G
Sbjct: 384 PNGRWGNSSSPAFGELKDYYLFYLKSKSPREELLKMWGEELTSEESVFEVFEHYLSGEPN 443
Query: 437 ----NLKSSPWSELDGLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGP 604
+ PW++ + L ET ++ E+L+++N G LTINSQP++NA+ S VGWG
Sbjct: 444 RHGYRVTCLPWND-EPLAAETSLMKEELLRVNRLGILTINSQPNINAKPSSDPVVGWGPS 502
Query: 605 GGYVYQKAYLEFFCSKEKLDAVVEKCKALP-SITYIAVN-KGDNWVSNTAQSDVNAVTWG 778
GGYV+QKAYLEFF S+E ++A+++ K + Y V+ KG+N ++N + NAVTWG
Sbjct: 503 GGYVFQKAYLEFFTSRETVEALLQVLKTYELRVNYHIVDVKGEN-ITNAPELQPNAVTWG 561
Query: 779 VFPAKEIIQPTIVDPASFKVWKDEAFETWSRSWANLYPESDPSRNLLEEVKNSYYLVSLV 958
+FP +EIIQPT+VDP SF WKDEAF W W LY E PSR +++ + ++Y+LV+LV
Sbjct: 562 IFPGREIIQPTVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYFLVNLV 621
Query: 959 ENDY 970
+N++
Sbjct: 622 DNEF 625
Score = 87 bits (215), Expect = 2e-016
Identities = 44/88 (50%), Positives = 56/88 (63%), Gaps = 2/88 (2%)
Frame = +3
Query: 9 YGIHLGTEMCRKILAHG-TKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPANV 185
YGI L +CR++L G LH YTLN E + + +L LGM E R LPW A+
Sbjct: 296 YGIELAVRLCRELLDSGLVPGLHFYTLNREVATMEVLKQLGMWTEDP-RRPLPWALSAHP 354
Query: 186 FRTKEDVRPIFWANRPKSYISRTKGWED 269
R +EDVRPIFWA+RPKSYI RT+ W++
Sbjct: 355 KRREEDVRPIFWASRPKSYIYRTQDWDE 382
>sp|Q60HE5|MTHR_MACFA Methylenetetrahydrofolate reductase OS=Macaca fascicularis
GN=MTHFR PE=2 SV=1
Length = 656
Score = 202 bits (513), Expect = 5e-051
Identities = 103/244 (42%), Positives = 152/244 (62%), Gaps = 13/244 (5%)
Frame = +2
Query: 272 PQGRWGDSRSASYGALTDHQ--FSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLG--- 436
P GRWG+S S ++G L D+ + + ++ + L + W L S E + E F G
Sbjct: 385 PNGRWGNSSSPAFGELKDYYLFYLKSKSPRELLLKMWGEELTSEESVFEVFVLYLSGEPN 444
Query: 437 ----NLKSSPWSELDGLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGP 604
+ PW++ + L ET ++ E+L+++N +G LTINSQP++N + S VGWG
Sbjct: 445 RNGHKVTCLPWND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPVVGWGPS 503
Query: 605 GGYVYQKAYLEFFCSKEKLDAVVEKCKALP-SITYIAVN-KGDNWVSNTAQSDVNAVTWG 778
GGYV+QKAYLEFF S+E +A+++ K + Y VN KG+N ++N + NAVTWG
Sbjct: 504 GGYVFQKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGEN-ITNAPELQPNAVTWG 562
Query: 779 VFPAKEIIQPTIVDPASFKVWKDEAFETWSRSWANLYPESDPSRNLLEEVKNSYYLVSLV 958
+FP +EIIQPT+VDP SF WKDEAF W W LY E PSR +++ + ++Y+LV+LV
Sbjct: 563 IFPGREIIQPTVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRTIIQYIHDNYFLVNLV 622
Query: 959 ENDY 970
+ND+
Sbjct: 623 DNDF 626
Score = 87 bits (213), Expect = 3e-016
Identities = 44/88 (50%), Positives = 55/88 (62%), Gaps = 2/88 (2%)
Frame = +3
Query: 9 YGIHLGTEMCRKILAHG-TKSLHLYTLNMEKSALAILMNLGMIDESKISRSLPWRRPANV 185
YGI L +C ++LA G LH YTLN E + +L LGM E R LPW A+
Sbjct: 297 YGIELAVSLCHELLASGLVPGLHFYTLNREMATTEVLKRLGMWTEDP-RRPLPWALSAHP 355
Query: 186 FRTKEDVRPIFWANRPKSYISRTKGWED 269
R +EDVRPIFWA+RPKSYI RT+ W++
Sbjct: 356 KRREEDVRPIFWASRPKSYIYRTQEWDE 383
>sp|Q5I598|MTHR_BOVIN Methylenetetrahydrofolate reductase OS=Bos taurus GN=MTHFR
PE=2 SV=1
Length = 655
Score = 200 bits (508), Expect = 2e-050
Identities = 100/244 (40%), Positives = 154/244 (63%), Gaps = 13/244 (5%)
Frame = +2
Query: 272 PQGRWGDSRSASYGALTDHQ--FSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLGNLK 445
P GRWG+S S ++G L D+ + + ++ ++L + W L S E + + F G
Sbjct: 384 PNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFQVFAHHLSGEPN 443
Query: 446 SS-------PWSELDGLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGP 604
+ PW++ + L ET ++ E+L+++N +G LTINSQP++N + S VGWG
Sbjct: 444 QNGYKVTCLPWND-EPLAAETSLMKEELLRVNRRGILTINSQPNINGKPSSDPIVGWGPS 502
Query: 605 GGYVYQKAYLEFFCSKEKLDAVVEKCKALP-SITYIAVN-KGDNWVSNTAQSDVNAVTWG 778
GGYV+QKAYLEFF S+E ++A+++ K + Y V+ KG+N ++N + NAVTWG
Sbjct: 503 GGYVFQKAYLEFFTSRETVEALLQVLKKYELRVNYHIVDVKGEN-ITNAPELQPNAVTWG 561
Query: 779 VFPAKEIIQPTIVDPASFKVWKDEAFETWSRSWANLYPESDPSRNLLEEVKNSYYLVSLV 958
+FP +EIIQPT+VDP SF WKDEAF W W LY E PSR +++ + ++Y+LV+LV
Sbjct: 562 IFPGREIIQPTVVDPVSFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYFLVNLV 621
Query: 959 ENDY 970
+N++
Sbjct: 622 DNEF 625
>sp|Q10258|MTHR1_SCHPO Methylenetetrahydrofolate reductase 1
OS=Schizosaccharomyces pombe GN=met9 PE=1 SV=1
Length = 603
Score = 196 bits (496), Expect = 4e-049
Identities = 104/244 (42%), Positives = 143/244 (58%), Gaps = 5/244 (2%)
Frame = +2
Query: 269 LPQGRWGDSRSASYGALTDHQFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLGNLKS 448
LP GRWGDSRS ++G ++ R K++ W P KS +I + F C + S
Sbjct: 345 LPHGRWGDSRSPAFGEFDAIRYGL-RMSPKEITTSWGSP-KSYSEIGDLFARYCEKKISS 402
Query: 449 SPWSELDGLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGPGGYVYQKA 628
PWS+L + E +I +QL+ +N FLTINSQP++N E+S GWG P GYV+QK
Sbjct: 403 LPWSDLP-ISDEADLIRDQLLSMNRNAFLTINSQPALNGEKSSHPVFGWGPPNGYVFQKP 461
Query: 629 YLEFFCSKEKLDAVVEKCKALPSITYIAVNKGDNWVSNTAQSDVNAVTWGVFPAKEIIQP 808
Y+EFF L+ + E K L S++Y NK + +N+ NAVTWGVFP +EIIQP
Sbjct: 462 YVEFFVHPSLLNELKETVKKLNSVSYFVTNKNGDLDTNSQYEIPNAVTWGVFPNREIIQP 521
Query: 809 TIVDPASFKVWKDEAFETWSRSWANLYPESDPSRNLLEEVKNSYYLVSLVENDYING-NI 985
TIV+ SF WKDEA+ + WAN Y SR LL + ++L +V+ND+ NG ++
Sbjct: 522 TIVESTSFLAWKDEAY-SLGMEWANAYSPDSISRKLLVSMMKEWFLCVIVDNDFQNGQSL 580
Query: 986 FTVF 997
F VF
Sbjct: 581 FDVF 584
>sp|Q17693|MTHR_CAEEL Probable methylenetetrahydrofolate reductase
OS=Caenorhabditis elegans GN=C06A8.1 PE=1 SV=2
Length = 663
Score = 171 bits (431), Expect = 1e-041
Identities = 83/177 (46%), Positives = 116/177 (65%), Gaps = 4/177 (2%)
Frame = +2
Query: 452 PWSELD-GLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGPGGYVYQKA 628
PW+E + G+QPET +I+EQLV N G LT+NSQPSVN S VGWG PGGY YQKA
Sbjct: 468 PWTEAETGVQPETSLISEQLVWCNENGILTVNSQPSVNGAPSTDPLVGWGKPGGYCYQKA 527
Query: 629 YLEFFCSKEKLDAVVEKC-KALP-SITYIAVNKGDNW-VSNTAQSDVNAVTWGVFPAKEI 799
YLE F + E D +++ + P + Y A+NK + +N+ ++ AVTWGVFP EI
Sbjct: 528 YLECFMTAELSDKLIQIIEREFPVRVNYHAINKDSTFDKTNSEETTPIAVTWGVFPGSEI 587
Query: 800 IQPTIVDPASFKVWKDEAFETWSRSWANLYPESDPSRNLLEEVKNSYYLVSLVENDY 970
QPT+VDP SF+ W+DEA++ W W + YP+ S +++ V + + LV+LV+ND+
Sbjct: 588 AQPTVVDPLSFRAWRDEAYQMWMAQWGDFYPKESKSYGVIKAVHDEFRLVTLVDNDF 644
>sp|O74927|MTHR2_SCHPO Methylenetetrahydrofolate reductase 2
OS=Schizosaccharomyces pombe GN=met11 PE=2 SV=2
Length = 641
Score = 163 bits (411), Expect = 3e-039
Identities = 87/237 (36%), Positives = 136/237 (57%), Gaps = 8/237 (3%)
Frame = +2
Query: 278 GRWGDSRSASYGALTDH--QFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLGNLKSS 451
GR+GD RS +YG + + P + KL W P+ DI F++ + ++ +
Sbjct: 401 GRFGDPRSPAYGEIDGYGPTLHFPPSEALKL---WGYPVDE-SDITSLFQKHIMSDISAI 456
Query: 452 PWSELDGLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGPGGYVYQKAY 631
PW + + ++ ETK I + L+K+N + T+ SQP+VN S GWG GG V+QKA+
Sbjct: 457 PWID-EPVEVETKTIAKYLLKLNGNSWWTVGSQPAVNGAPSADPVFGWGPKGGRVFQKAF 515
Query: 632 LEFFCSKEKLDAVVEKCKALPSITYIAVNKGDNWVSNTAQSDVNAVTWGVFPAKEIIQPT 811
+E F + + L + K P +TY A N +++N + +AVTWGV+P +EIIQ T
Sbjct: 516 VECFVNGKDLKDFITKWHDNPQVTYYAGNNKSEFLTNAPKDGASAVTWGVYPGREIIQST 575
Query: 812 IVDPASFKVWKDEAFETWSRSWANLYPESDPSRNLLEEVKNSYYLVSLVENDYINGN 982
I+ SFK W E+F+ W WANLY ++ PSR LLE N +LV+++ +D+++ N
Sbjct: 576 IIAEVSFKAWLSESFQVWG-EWANLYSKNTPSRKLLENCINDRWLVTVIHHDFMDKN 631
>sp|P46151|MTHR1_YEAST Methylenetetrahydrofolate reductase 1 OS=Saccharomyces
cerevisiae GN=MET12 PE=1 SV=2
Length = 657
Score = 163 bits (410), Expect = 4e-039
Identities = 87/236 (36%), Positives = 138/236 (58%), Gaps = 7/236 (2%)
Frame = +2
Query: 272 PQGRWGDSRSASYGALTDHQFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLGNLKSS 451
P GR+GDSRS +YG + + S ++ K L+ W +P K++ D+++ F + G+ +
Sbjct: 412 PNGRFGDSRSPAYGEIDGYGPSIKVSKSKALEL-WGIP-KTIGDLKDIFIKYLEGSTDAI 469
Query: 452 PWSELDGLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGPGGYVYQKAY 631
PWS+L GL ET +I E+L+++N +G+LT+ SQP+ NA S GWG G +YQKA+
Sbjct: 470 PWSDL-GLSAETALIQEELIQLNYRGYLTLASQPATNATLSSDKIFGWGPAKGRLYQKAF 528
Query: 632 LEFFCSKEKLDAVVE---KCKALPSITYIAVNKGDNWVSNTAQSDVNAVTWGVFPAKEII 802
+E F +++ + ++ +Y A + ++ +N + VTWGVFP +
Sbjct: 529 VEMFIHRQQWETTLKPKLDHYGRRKFSYYAGDSSGSFETNLDPHSSSVVTWGVFPNSPVK 588
Query: 803 QPTIVDPASFKVWKDEAFETWSRSWANLYPESDPSRNLLEEVKNSYYLVSLVENDY 970
Q TI++ SFK W+DEAF WS WA L+P + P+ LL V Y LVS+V +D+
Sbjct: 589 QTTIIEEESFKAWRDEAFSIWS-EWAKLFPRNTPANILLRLVHKDYCLVSIVHHDF 643
>sp|P53128|MTHR2_YEAST Methylenetetrahydrofolate reductase 2 OS=Saccharomyces
cerevisiae GN=MET13 PE=1 SV=2
Length = 600
Score = 158 bits (397), Expect = 1e-037
Identities = 90/237 (37%), Positives = 129/237 (54%), Gaps = 4/237 (1%)
Frame = +2
Query: 272 PQGRWGDSRSASYGALTDHQFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLGNLKSS 451
P GR+GDS S ++G L R K + W P S+ D+ GNLK
Sbjct: 354 PNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLELWSTP-TSINDVAFLVINYLNGNLKCL 412
Query: 452 PWSELDGLQPETKIINEQLVKINSKGFLTINSQPSVNAERSDSSTVGWGGPGGYVYQKAY 631
PWS++ + E I L+++N +TINSQP VN RS+ GWG GYVYQK Y
Sbjct: 413 PWSDIP-INDEINPIKAHLIELNQHSIITINSQPQVNGIRSNDKIHGWGPKDGYVYQKQY 471
Query: 632 LEFFCSKEKLDAVVEKCKALPSITYIAV-NKGDNWVSNTAQSDVNAVTWGVFPAKEIIQP 808
LEF K KL +++ K +TY A+ ++GD ++ S NAVTWG+FP +EI+QP
Sbjct: 472 LEFMLPKTKLPKLIDTLKNNEFLTYFAIDSQGDLLSNHPDNSKSNAVTWGIFPGREILQP 531
Query: 809 TIVDPASFKVWKDEAFETWSRSWANLYPESDP-SRNLLEEVKNSYYLVSLVENDYIN 976
TIV+ SF WK+E + + N+ P S ++ + + Y LV++V+NDYI+
Sbjct: 532 TIVEKISFLAWKEEFYHILNEWKLNMNKYDKPHSAQFIQSLIDDYCLVNIVDNDYIS 588
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,472,851,095
Number of Sequences: 518415
Number of Extensions: 69472851095
Number of Successful Extensions: 496854919
Number of sequences better than 0.0: 0
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