BLASTX 7.6.2
Query= UN17090 /QuerySize=1691
(1690 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q6PAV2|HERC4_MOUSE Probable E3 ubiquitin-protein ligase HERC4... 216 6e-055
sp|Q5PQN1|HERC4_RAT Probable E3 ubiquitin-protein ligase HERC4 O... 215 1e-054
sp|Q5GLZ8|HERC4_HUMAN Probable E3 ubiquitin-protein ligase HERC4... 213 4e-054
sp|Q15751|HERC1_HUMAN Probable E3 ubiquitin-protein ligase HERC1... 205 8e-052
sp|Q15034|HERC3_HUMAN Probable E3 ubiquitin-protein ligase HERC3... 204 2e-051
sp|O95714|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 OS=Homo ... 203 5e-051
sp|Q4U2R1|HERC2_MOUSE E3 ubiquitin-protein ligase HERC2 OS=Mus m... 203 5e-051
sp|Q9VR91|HERC2_DROME Probable E3 ubiquitin-protein ligase HERC2... 195 9e-049
sp|Q6NXM2|RCBT1_MOUSE RCC1 and BTB domain-containing protein 1 O... 154 3e-036
sp|Q8NDN9|RCBT1_HUMAN RCC1 and BTB domain-containing protein 1 O... 152 1e-035
sp|Q9UII4|HERC5_HUMAN Probable E3 ubiquitin-protein ligase HERC5... 148 1e-034
>sp|Q6PAV2|HERC4_MOUSE Probable E3 ubiquitin-protein ligase HERC4 OS=Mus
musculus GN=Herc4 PE=2 SV=2
Length = 1057
Score = 216 bits (548), Expect = 6e-055
Identities = 121/328 (36%), Positives = 184/328 (56%), Gaps = 14/328 (4%)
Frame = -3
Query: 1523 DEAVTAPPR--------KVLLISAGASHSVALLTGDVVCSWGRGEDGQLGHGDAEDRPSP 1368
DE + PR KV + G H+V +L V + G + GQLGH + R P
Sbjct: 18 DEEIVLEPRRSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGH--EKSRKKP 75
Query: 1367 TQLSALDEHQIVSVTCGADHTVAYSQSRSEVYSWGWGDFGRLG-HGNSSDLFTPLPIKAL 1191
Q+ ALD IV+V CG HT+A + + +VY+WG G+LG G+ + P IK+L
Sbjct: 76 EQVVALDAQNIVAVACGEAHTLALN-DKGQVYAWGLDSDGQLGLQGSEECIRVPRNIKSL 134
Query: 1190 HGVRIKQIACGDSHCLAVTMEGEVQSWGRNQNGQLGLG-DTEDSLVPRKIQAFEGIRIKM 1014
++I Q+ACG H LA++ EV WG+N+ GQLGLG D + P+ I++ GI
Sbjct: 135 SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIDCQKQTSPQLIKSLLGIPFMQ 194
Query: 1013 VAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHT 834
VAAG H+ +T G ++GWG ++G LGL D NDR VP + S ++K+ + CG HT
Sbjct: 195 VAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHT 254
Query: 833 ISVSYSGALYTYGWSKYGQLGHGDLEDHLIPHKLEALGNNVISQISGGWRHTMA-LTSDG 657
+++ G ++T+G YGQLGH + P K+ L ++++Q++ G +HT A + S G
Sbjct: 255 AALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSG 314
Query: 656 KLYGWGWNKFGQVGVGDNIDQCSPVQVR 573
++Y +G GQ+G G ++ SP V+
Sbjct: 315 RIYSFGLGGNGQLGTGSTSNRKSPFTVK 342
Score = 168 bits (423), Expect = 2e-040
Identities = 92/264 (34%), Positives = 146/264 (55%), Gaps = 4/264 (1%)
Frame = -3
Query: 1523 DEAVTAPPRKVLLISAGASHSVALLTGDVVCSWGRGEDGQLG-HGDAEDRPSPTQLSALD 1347
++ V + ++ ++ G +H++AL V +WG DGQLG G E P + +L
Sbjct: 76 EQVVALDAQNIVAVACGEAHTLALNDKGQVYAWGLDSDGQLGLQGSEECIRVPRNIKSLS 135
Query: 1346 EHQIVSVTCGADHTVAYSQSRSEVYSWGWGDFGRLGHG-NSSDLFTPLPIKALHGVRIKQ 1170
+ QIV V CG H++A S++ SEV+ WG +G+LG G + +P IK+L G+ Q
Sbjct: 136 DIQIVQVACGYYHSLALSKA-SEVFCWGQNKYGQLGLGIDCQKQTSPQLIKSLLGIPFMQ 194
Query: 1169 IACGDSHCLAVTMEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAGAEHT 990
+A G +H +T+ G + WGRN+ GQLGL D D VP +++ +I + G +HT
Sbjct: 195 VAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHT 254
Query: 989 AAVTEDGDLYGWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTIS-VSYSG 813
AA+T++G ++ +G G YG LG + + P +V ++ VACG +HT + V SG
Sbjct: 255 AALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQVACGRQHTSAFVPSSG 314
Query: 812 ALYTYGWSKYGQLGHGDLEDHLIP 741
+Y++G GQLG G + P
Sbjct: 315 RIYSFGLGGNGQLGTGSTSNRKSP 338
>sp|Q5PQN1|HERC4_RAT Probable E3 ubiquitin-protein ligase HERC4 OS=Rattus
norvegicus GN=Herc4 PE=2 SV=1
Length = 1057
Score = 215 bits (546), Expect = 1e-054
Identities = 121/328 (36%), Positives = 185/328 (56%), Gaps = 14/328 (4%)
Frame = -3
Query: 1523 DEAVTAPPR--------KVLLISAGASHSVALLTGDVVCSWGRGEDGQLGHGDAEDRPSP 1368
DE + PR KV + G H+V +L V + G + GQLGH + R P
Sbjct: 18 DEEIVLEPRKSDFFVNKKVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGH--EKSRKKP 75
Query: 1367 TQLSALDEHQIVSVTCGADHTVAYSQSRSEVYSWGWGDFGRLG-HGNSSDLFTPLPIKAL 1191
Q+ ALD IV+V+CG HT+A + + +VY+WG G+LG G+ + P IK+L
Sbjct: 76 EQVVALDAQNIVAVSCGEAHTLALN-DKGQVYAWGLDSDGQLGLQGSEECIRVPRNIKSL 134
Query: 1190 HGVRIKQIACGDSHCLAVTMEGEVQSWGRNQNGQLGLG-DTEDSLVPRKIQAFEGIRIKM 1014
++I Q+ACG H LA++ EV WG+N+ GQLGLG + + P+ I++ GI
Sbjct: 135 SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGIECQKQTSPQLIKSLLGIPFMQ 194
Query: 1013 VAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHT 834
VAAG H+ +T G ++GWG ++G LGL D NDR VP + S ++K+ + CG HT
Sbjct: 195 VAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHT 254
Query: 833 ISVSYSGALYTYGWSKYGQLGHGDLEDHLIPHKLEALGNNVISQISGGWRHTMA-LTSDG 657
+++ G ++T+G YGQLGH + P K+ L ++++QI+ G +HT A + S G
Sbjct: 255 AALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSG 314
Query: 656 KLYGWGWNKFGQVGVGDNIDQCSPVQVR 573
++Y +G GQ+G G ++ SP V+
Sbjct: 315 RIYSFGLGGNGQLGTGSTSNRKSPFTVK 342
Score = 168 bits (425), Expect = 1e-040
Identities = 93/264 (35%), Positives = 145/264 (54%), Gaps = 4/264 (1%)
Frame = -3
Query: 1523 DEAVTAPPRKVLLISAGASHSVALLTGDVVCSWGRGEDGQLG-HGDAEDRPSPTQLSALD 1347
++ V + ++ +S G +H++AL V +WG DGQLG G E P + +L
Sbjct: 76 EQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLQGSEECIRVPRNIKSLS 135
Query: 1346 EHQIVSVTCGADHTVAYSQSRSEVYSWGWGDFGRLGHGNSSDLFT-PLPIKALHGVRIKQ 1170
+ QIV V CG H++A S++ SEV+ WG +G+LG G T P IK+L G+ Q
Sbjct: 136 DIQIVQVACGYYHSLALSKA-SEVFCWGQNKYGQLGLGIECQKQTSPQLIKSLLGIPFMQ 194
Query: 1169 IACGDSHCLAVTMEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAGAEHT 990
+A G +H +T+ G + WGRN+ GQLGL D D VP +++ +I + G +HT
Sbjct: 195 VAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHT 254
Query: 989 AAVTEDGDLYGWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTIS-VSYSG 813
AA+T++G ++ +G G YG LG + + P +V ++ +ACG +HT + V SG
Sbjct: 255 AALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTQIACGRQHTSAFVPSSG 314
Query: 812 ALYTYGWSKYGQLGHGDLEDHLIP 741
+Y++G GQLG G + P
Sbjct: 315 RIYSFGLGGNGQLGTGSTSNRKSP 338
>sp|Q5GLZ8|HERC4_HUMAN Probable E3 ubiquitin-protein ligase HERC4 OS=Homo
sapiens GN=HERC4 PE=1 SV=1
Length = 1057
Score = 213 bits (541), Expect = 4e-054
Identities = 120/328 (36%), Positives = 185/328 (56%), Gaps = 14/328 (4%)
Frame = -3
Query: 1523 DEAVTAPPRK--------VLLISAGASHSVALLTGDVVCSWGRGEDGQLGHGDAEDRPSP 1368
DE + PRK V + G H+V +L V + G + GQLGH + R P
Sbjct: 18 DEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGH--EKSRKKP 75
Query: 1367 TQLSALDEHQIVSVTCGADHTVAYSQSRSEVYSWGWGDFGRLG-HGNSSDLFTPLPIKAL 1191
Q+ ALD IV+V+CG HT+A + + +VY+WG G+LG G+ + P IK+L
Sbjct: 76 EQVVALDAQNIVAVSCGEAHTLALN-DKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL 134
Query: 1190 HGVRIKQIACGDSHCLAVTMEGEVQSWGRNQNGQLGLG-DTEDSLVPRKIQAFEGIRIKM 1014
++I Q+ACG H LA++ EV WG+N+ GQLGLG D + P+ +++ GI
Sbjct: 135 SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQ 194
Query: 1013 VAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHT 834
VAAG H+ +T G ++GWG ++G LGL D NDR VP + S ++K+ + CG HT
Sbjct: 195 VAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHT 254
Query: 833 ISVSYSGALYTYGWSKYGQLGHGDLEDHLIPHKLEALGNNVISQISGGWRHTMA-LTSDG 657
+++ G ++T+G YGQLGH + P K+ L +++++I+ G +HT A + S G
Sbjct: 255 AALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSG 314
Query: 656 KLYGWGWNKFGQVGVGDNIDQCSPVQVR 573
++Y +G GQ+G G ++ SP V+
Sbjct: 315 RIYSFGLGGNGQLGTGSTSNRKSPFTVK 342
>sp|Q15751|HERC1_HUMAN Probable E3 ubiquitin-protein ligase HERC1 OS=Homo
sapiens GN=HERC1 PE=1 SV=2
Length = 4861
Score = 205 bits (521), Expect = 8e-052
Identities = 124/369 (33%), Positives = 193/369 (52%), Gaps = 13/369 (3%)
Frame = -3
Query: 1427 WGRGEDGQLGHGDAEDRPSPTQLSALDEHQIVSVTCGADHTVAYSQSRSEVYSWGWGDFG 1248
WG G GQL R +A Q V CG + T Q+ V + G G +G
Sbjct: 4002 WGAGRHGQLAEA---GRNVMVPAAAPSFSQAQQVICGQNCTFVI-QANGTVLACGEGSYG 4057
Query: 1247 RLGHGNSSDLFTPLPIKALHGVRIKQI--ACG-DSHCLAVTMEGEVQSWGRNQNGQLGLG 1077
RLG GNS DL I AL G + Q+ +CG D H +A+T GEV SWG G+LG G
Sbjct: 4058 RLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHG 4117
Query: 1076 DTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDRNDRLVP 897
+++ PR+I+A +G + ++ G +H+A VT DG L+ +G G YG LGLG+ +++ +P
Sbjct: 4118 NSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLP 4177
Query: 896 ERVTSAGAEKMSMVACGWRHTISVSYSGAL-YTYGWSKYGQLGHGDLEDHLIPHKLEALG 720
ERVT+ ++ VACG HT++VS G++ + +G YG+LG G+ P K++ L
Sbjct: 4178 ERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLC 4237
Query: 719 NNVISQISGGWRHTMALTSDGKLYGWGWNKFGQVGVGDNIDQCSPVQVRFPDDQKVVQVS 540
I +++ G + ++ALT DG +Y +G ++ + G + P Q+ + V+
Sbjct: 4238 GIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVA 4297
Query: 539 CGWRHTLAVTERNNVFAWGRGTNGQLGIGESLDRNSPKIIEALSVDGASGQQIESSNFDP 360
G HTLA+ +V+AWG + GQLG+G + P + V G G+ + +
Sbjct: 4298 VGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTL-----VTGLQGKNVRQISAGR 4352
Query: 359 SSGKSWVSP 333
+W +P
Sbjct: 4353 CHSAAWTAP 4361
Score = 204 bits (518), Expect = 2e-051
Identities = 113/329 (34%), Positives = 183/329 (55%), Gaps = 5/329 (1%)
Frame = -3
Query: 1484 ISAGASHSVALLTGDVVCSWGRGEDGQLGHGDAEDRPSPTQLSALDEHQIVSV--TCGAD 1311
+ G + + + V + G G G+LG G+++D T +SAL + + +CG+D
Sbjct: 4032 VICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSD 4091
Query: 1310 -HTVAYSQSRSEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGVRIKQIACGDSHCLAVT 1134
H++A ++S EV+SWG GD+G+LGHGNS P I+AL G + Q++CG H VT
Sbjct: 4092 GHSMALTES-GEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVT 4150
Query: 1133 MEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDGDL-YG 957
+G++ ++G G+LGLG+T + +P ++ A EG +I VA G HT AV+ DG + +
Sbjct: 4151 SDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWA 4210
Query: 956 WGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTISVSYSGALYTYGWSKYGQ 777
+G G YG LGLG+ + P+++ + VACG + +++++ G +YT+G +
Sbjct: 4211 FGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIG 4270
Query: 776 LGHGDLEDHLIPHKLEALGNNVISQISGGWRHTMALTSDGKLYGWGWNKFGQVGVGDNID 597
L G +H P ++ L +I ++ G HT+AL S+G +Y WG N GQ+G+G
Sbjct: 4271 LPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNH 4330
Query: 596 QCSPVQVRFPDDQKVVQVSCGWRHTLAVT 510
P V + V Q+S G H+ A T
Sbjct: 4331 VREPTLVTGLQGKNVRQISAGRCHSAAWT 4359
>sp|Q15034|HERC3_HUMAN Probable E3 ubiquitin-protein ligase HERC3 OS=Homo
sapiens GN=HERC3 PE=1 SV=1
Length = 1050
Score = 204 bits (517), Expect = 2e-051
Identities = 114/312 (36%), Positives = 178/312 (57%), Gaps = 8/312 (2%)
Frame = -3
Query: 1499 RKVLLISAGASHSVALLTGDVVCSWGRGEDGQLGHGDAEDRPSPTQLSALDEHQIVSVTC 1320
R V ++ G +HSV LL V + G GQLGH + P Q+ AL + I+ V C
Sbjct: 34 RSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGALADQHIIHVAC 91
Query: 1319 GADHTVAYSQSRSEVYSWGWGDFGRLGHGNSSD-LFTPLPIKALHGVRIKQIACGDSHCL 1143
G H++A S R +++SWG G G+LG + D + P I+ L+ I Q++CG+ HCL
Sbjct: 92 GESHSLALS-DRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCL 150
Query: 1142 AVTMEGEVQSWGRNQNGQLGLG-DTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDGD 966
A+ +G+ +WG+N +GQLGLG + P+++++ EGI + VAAG H+ A++ G
Sbjct: 151 ALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA 210
Query: 965 LYGWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTISVSYSGALYTYGWSK 786
++GWG G LGL D DR P V +K+ ++CG HT ++ SG ++T+G
Sbjct: 211 VFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGS 270
Query: 785 YGQLGHGDLEDHLIPHKLEALGNNVISQISGGWRHTMA-LTSDGKLYGWGWNKFGQVGVG 609
GQLGH + D + P ++ L + ++QI+ G +HT+A + S G +Y +G GQ+G G
Sbjct: 271 CGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTG 330
Query: 608 D--NIDQCSPVQ 579
N+ SPV+
Sbjct: 331 HTCNVKCPSPVK 342
Score = 156 bits (394), Expect = 4e-037
Identities = 84/246 (34%), Positives = 136/246 (55%), Gaps = 4/246 (1%)
Frame = -3
Query: 1493 VLLISAGASHSVALLTGDVVCSWGRGEDGQLGHGDAEDRPS-PTQLSALDEHQIVSVTCG 1317
++ ++ G SHS+AL + SWG G DGQLG ED + P + L++ I+ V+CG
Sbjct: 86 IIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCG 145
Query: 1316 ADHTVAYSQSRSEVYSWGWGDFGRLGHGNS-SDLFTPLPIKALHGVRIKQIACGDSHCLA 1140
H +A + + + ++WG G+LG G +P +++L G+ + Q+A G +H A
Sbjct: 146 NWHCLALA-ADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA 204
Query: 1139 VTMEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDGDLY 960
+++ G V WG N GQLGL D +D P ++ ++ ++ G EHTA +T+ G ++
Sbjct: 205 LSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVF 264
Query: 959 GWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTIS-VSYSGALYTYGWSKY 783
+G G G LG ND + P RV +++ +ACG +HT++ V SG +Y +G
Sbjct: 265 TFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGAR 324
Query: 782 GQLGHG 765
GQLG G
Sbjct: 325 GQLGTG 330
>sp|O95714|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens
GN=HERC2 PE=1 SV=1
Length = 4834
Score = 203 bits (514), Expect = 5e-051
Identities = 116/346 (33%), Positives = 186/346 (53%), Gaps = 5/346 (1%)
Frame = -3
Query: 1436 VCSWGRGEDGQLGHGDAEDRPSPTQLSALDEHQIVSVTCGADHTVAYSQSRSEVYSWGWG 1257
+ WG GQLG + PT AL + V + G + T+ + ++Y+ G+G
Sbjct: 3954 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQL-IGGEQTLFAVTADGKLYATGYG 4012
Query: 1256 DFGRLGHGNSSDLFTPLPIKALHGVRIKQIA--CGDSHCLAVTMEGEVQSWGRNQNGQLG 1083
GRLG G + + TP ++++ V IK++A G HCLA++ EGEV SWG ++G+LG
Sbjct: 4013 AGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLG 4072
Query: 1082 LGDTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDRNDRL 903
G+ PR I++ GI + VAAG H+A VT GDLY WG GRYG LG D D+L
Sbjct: 4073 HGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQL 4132
Query: 902 VPERVTSAGAEKMSMVACGW--RHTISVSYSGALYTYGWSKYGQLGHGDLEDHLIPHKLE 729
P+ V + ++ +ACG T+ ++ ++++G YG+LG G + +P K++
Sbjct: 4133 KPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKID 4192
Query: 728 ALGNNVISQISGGWRHTMALTSDGKLYGWGWNKFGQVGVGDNIDQCSPVQVRFPDDQKVV 549
+L + ++ G + ++ALT G +Y WG + ++G G + P QV+ +KV+
Sbjct: 4193 SLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVI 4252
Query: 548 QVSCGWRHTLAVTERNNVFAWGRGTNGQLGIGESLDRNSPKIIEAL 411
++ G H + TE V+ WG GQLG G + P+++ AL
Sbjct: 4253 AIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAAL 4298
Score = 159 bits (401), Expect = 7e-038
Identities = 79/228 (34%), Positives = 126/228 (55%), Gaps = 1/228 (0%)
Frame = -3
Query: 1496 KVLLISAGASHSVALLTGDVVCSWGRGEDGQLGHGDAEDRPSPTQLSALDEHQIVSVTCG 1317
+V+ ++AG +HS + + +WG+G G+LGH D+ED+ P + AL H++V + CG
Sbjct: 4092 EVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACG 4151
Query: 1316 A-DHTVAYSQSRSEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGVRIKQIACGDSHCLA 1140
+ D V+SWG GD+G+LG G S P+ I +L G+ + ++ CG +A
Sbjct: 4152 SGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVA 4211
Query: 1139 VTMEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDGDLY 960
+T G V +WG+ +LG G + PR++Q +G ++ +A G+ H TEDG++Y
Sbjct: 4212 LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVY 4271
Query: 959 GWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTISVSYS 816
WG G LG G N P V + +K++ VACG HT++ S S
Sbjct: 4272 TWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTS 4319
Score = 148 bits (372), Expect = 2e-034
Identities = 80/225 (35%), Positives = 117/225 (52%), Gaps = 1/225 (0%)
Frame = -3
Query: 1499 RKVLLISAGASHSVALLTGDVVCSWGRGEDGQLGHGDAEDRPSPTQLSALDEHQIVSVTC 1320
+++ I+ G+SHS AL + + +WG GE G+LGHGD + P + L H+++ V C
Sbjct: 3099 KRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVAC 3158
Query: 1319 GA-DHTVAYSQSRSEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGVRIKQIACGDSHCL 1143
G+ D V+SWG GDFG+LG G S P I+ L+G + QI CG L
Sbjct: 3159 GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSL 3218
Query: 1142 AVTMEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDGDL 963
A+T G V +WG+ +LG G P+ ++ G +I VA GA H AVT+ G +
Sbjct: 3219 ALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQV 3278
Query: 962 YGWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTIS 828
Y WG +G G G P V +K++ VACG H+++
Sbjct: 3279 YAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVA 3323
>sp|Q4U2R1|HERC2_MOUSE E3 ubiquitin-protein ligase HERC2 OS=Mus musculus
GN=Herc2 PE=1 SV=2
Length = 4836
Score = 203 bits (514), Expect = 5e-051
Identities = 116/346 (33%), Positives = 186/346 (53%), Gaps = 5/346 (1%)
Frame = -3
Query: 1436 VCSWGRGEDGQLGHGDAEDRPSPTQLSALDEHQIVSVTCGADHTVAYSQSRSEVYSWGWG 1257
+ WG GQLG + PT AL + V + G + T+ + ++Y+ G+G
Sbjct: 3956 IYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQL-IGGEQTLFAVTADGKLYATGYG 4014
Query: 1256 DFGRLGHGNSSDLFTPLPIKALHGVRIKQIA--CGDSHCLAVTMEGEVQSWGRNQNGQLG 1083
GRLG G + + TP ++++ V IK++A G HCLA++ EGEV SWG ++G+LG
Sbjct: 4015 AGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLG 4074
Query: 1082 LGDTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDRNDRL 903
G+ PR I++ GI + VAAG H+A VT GDLY WG GRYG LG D D+L
Sbjct: 4075 HGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQL 4134
Query: 902 VPERVTSAGAEKMSMVACGW--RHTISVSYSGALYTYGWSKYGQLGHGDLEDHLIPHKLE 729
P+ V + ++ +ACG T+ ++ ++++G YG+LG G + +P K++
Sbjct: 4135 KPKLVEALQGHRVIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKID 4194
Query: 728 ALGNNVISQISGGWRHTMALTSDGKLYGWGWNKFGQVGVGDNIDQCSPVQVRFPDDQKVV 549
+L + ++ G + ++ALT G +Y WG + ++G G + P QV+ +KV+
Sbjct: 4195 SLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVI 4254
Query: 548 QVSCGWRHTLAVTERNNVFAWGRGTNGQLGIGESLDRNSPKIIEAL 411
++ G H + TE V+ WG GQLG G + P+++ AL
Sbjct: 4255 AIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAAL 4300
Score = 159 bits (400), Expect = 9e-038
Identities = 78/228 (34%), Positives = 126/228 (55%), Gaps = 1/228 (0%)
Frame = -3
Query: 1496 KVLLISAGASHSVALLTGDVVCSWGRGEDGQLGHGDAEDRPSPTQLSALDEHQIVSVTCG 1317
+V+ ++AG +HS + + +WG+G G+LGH D+ED+ P + AL H+++ + CG
Sbjct: 4094 EVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVIDIACG 4153
Query: 1316 A-DHTVAYSQSRSEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGVRIKQIACGDSHCLA 1140
+ D V+SWG GD+G+LG G S P+ I +L G+ + ++ CG +A
Sbjct: 4154 SGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVA 4213
Query: 1139 VTMEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDGDLY 960
+T G V +WG+ +LG G + PR++Q +G ++ +A G+ H TEDG++Y
Sbjct: 4214 LTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVY 4273
Query: 959 GWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTISVSYS 816
WG G LG G N P V + +K++ VACG HT++ S S
Sbjct: 4274 TWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTS 4321
>sp|Q9VR91|HERC2_DROME Probable E3 ubiquitin-protein ligase HERC2 OS=Drosophila
melanogaster GN=HERC2 PE=1 SV=3
Length = 4912
Score = 195 bits (495), Expect = 9e-049
Identities = 115/365 (31%), Positives = 190/365 (52%), Gaps = 8/365 (2%)
Frame = -3
Query: 1484 ISAGASHSVALLTGDVVCS---WGRGEDGQLGHGDAEDRPSPTQLSALDEHQIVSVTCGA 1314
+S + A D+ C+ WG + QLG PT + + + + G+
Sbjct: 2969 VSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGS 3028
Query: 1313 DHTVAYSQSRSEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGVRIKQIA--CGDSHCLA 1140
SQ +VY+ G G GRLG G + ++ P + L +K++A G H LA
Sbjct: 3029 KSLFIVSQD-GKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALA 3087
Query: 1139 VTMEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDGDLY 960
+T++G+V SWG ++G+LG G+ PR ++A +I+ VA G+ H+AA++ G+LY
Sbjct: 3088 LTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELY 3147
Query: 959 GWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWR--HTISVSYSGALYTYGWSK 786
WG G YG LG GD +L P+ VT+ ++ VACG R T++++ GA++++G
Sbjct: 3148 TWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGD 3207
Query: 785 YGQLGHGDLEDHLIPHKLEALGNNVISQISGGWRHTMALTSDGKLYGWGWNKFGQVGVGD 606
+G+LG G E PH++E L + QI G + ++ALT G+++ WG + ++G G
Sbjct: 3208 FGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGG 3267
Query: 605 NIDQCSPVQVRFPDDQKVVQVSCGWRHTLAVTERNNVFAWGRGTNGQLGIGESLDRNSPK 426
+ P + ++V+ V+ G H LAVT+ V+AWG +GQ G G + P
Sbjct: 3268 DQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPA 3327
Query: 425 IIEAL 411
++ L
Sbjct: 3328 LVIGL 3332
Score = 181 bits (457), Expect = 2e-044
Identities = 98/280 (35%), Positives = 156/280 (55%), Gaps = 3/280 (1%)
Frame = -3
Query: 1496 KVLLISAGASHSVALLTGDVVCSWGRGEDGQLGHGDAEDRPSPTQLSALDEHQIVSVTCG 1317
K + +++G H +AL T V +WG GEDG+LGHG+ P + L+ + + CG
Sbjct: 4137 KKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACG 4196
Query: 1316 ADHTVAYSQSRSEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGVRIKQIAC--GDSHCL 1143
+ H+ A + S V +WG G +GRLGHG+S D P ++AL G R IAC GD+ L
Sbjct: 4197 SAHSAAITAS-GHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTL 4255
Query: 1142 AVTMEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDGDL 963
+T + V SWG G+LG G ++ +P KI++ G+ + V G++ + A+T+ G +
Sbjct: 4256 CITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAV 4315
Query: 962 YGWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTISVSYSGALYTYGWSKY 783
Y WG G + LG G + P++V + +K+ +A G H ++ S SG +YT+G +
Sbjct: 4316 YTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDE 4375
Query: 782 GQLGHGDLEDHLIPHKLEALGNNVISQISGGWRHTMALTS 663
GQLG G + P + AL I +++ G HT+AL++
Sbjct: 4376 GQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALST 4415
Score = 150 bits (378), Expect = 3e-035
Identities = 85/226 (37%), Positives = 124/226 (54%), Gaps = 3/226 (1%)
Frame = -3
Query: 1499 RKVLLISAGASHSVALLTGDVVCSWGRGEDGQLGHGDAEDRPSPTQLSALDEHQIVSVTC 1320
+K+ ++ G+SHS A+ + + +WG GE G+LGHGD + P ++AL ++V V C
Sbjct: 3125 KKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVAC 3184
Query: 1319 GA--DHTVAYSQSRSEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGVRIKQIACGDSHC 1146
G+ T+A ++ V+SWG GDFG+LG G S TP I+ L G+ + QI CG
Sbjct: 3185 GSRDAQTLALTED-GAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFS 3243
Query: 1145 LAVTMEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDGD 966
LA+T GEV +WG+ +LG G + P+ I G R+ VA GA H AVT+ G
Sbjct: 3244 LALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQ 3303
Query: 965 LYGWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTIS 828
+Y WG +G G G+ P V A ++ VACG H+I+
Sbjct: 3304 VYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSIA 3349
>sp|Q6NXM2|RCBT1_MOUSE RCC1 and BTB domain-containing protein 1 OS=Mus musculus
GN=Rcbtb1 PE=2 SV=1
Length = 531
Score = 154 bits (387), Expect = 3e-036
Identities = 83/241 (34%), Positives = 133/241 (55%), Gaps = 5/241 (2%)
Frame = -3
Query: 1499 RKVLLISAGASHSVALLTGD-VVCSWGRGEDGQLGHGDAEDRPSPTQL-SALDEHQIVSV 1326
+K+ +S G+ V L T D VV +WG QLG+G +P Q+ + L Q++ V
Sbjct: 74 KKIKSLSYGSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEV 133
Query: 1325 TCGADHTVAYSQSRSEVYSWGWGDFGRLGHGNSSDLFTPLPI-KALHGVRIKQIACGDSH 1149
CG+ H++A + + E+++WG+ + G++G G++++ TP + LH R+ IACG +
Sbjct: 134 ACGSHHSMALA-ADGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIACGQTS 192
Query: 1148 CLAVTMEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDG 969
+AV GEV WG N NGQLGLG+ + L P ++ A G+ + + G HT A+T++G
Sbjct: 193 SMAVLDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEG 252
Query: 968 DLYGWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTISVSYSGALYTYGWS 789
LY WG YG LG G +N+ L P ++ + + AC HT + G + Y W
Sbjct: 253 LLYAWGANTYGQLGTGSKNNLLSPTQIMVEKERVIEIAACHSTHTSAAKTQGG-HVYMWG 311
Query: 788 K 786
+
Sbjct: 312 Q 312
>sp|Q8NDN9|RCBT1_HUMAN RCC1 and BTB domain-containing protein 1 OS=Homo sapiens
GN=RCBTB1 PE=2 SV=1
Length = 531
Score = 152 bits (382), Expect = 1e-035
Identities = 84/241 (34%), Positives = 132/241 (54%), Gaps = 5/241 (2%)
Frame = -3
Query: 1499 RKVLLISAGASHSVALLTGD-VVCSWGRGEDGQLGHGDAEDRPSPTQL-SALDEHQIVSV 1326
+K+ +S G+ V L T D VV +WG QLG+G +P Q+ + L Q+V V
Sbjct: 74 KKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEV 133
Query: 1325 TCGADHTVAYSQSRSEVYSWGWGDFGRLGHGNSSDLFTPLPI-KALHGVRIKQIACGDSH 1149
CG+ H++A + + EV++WG+ + G++G G++++ TP + LH R+ IACG +
Sbjct: 134 ACGSHHSMALA-ADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTS 192
Query: 1148 CLAVTMEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAGAEHTAAVTEDG 969
+AV GEV WG N NGQLGLG+ + L P ++ A + + + G HT A+T++G
Sbjct: 193 SMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEG 252
Query: 968 DLYGWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTISVSYSGALYTYGWS 789
LY WG YG LG G++N+ L P + + + AC HT + G + Y W
Sbjct: 253 LLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGG-HVYMWG 311
Query: 788 K 786
+
Sbjct: 312 Q 312
>sp|Q9UII4|HERC5_HUMAN Probable E3 ubiquitin-protein ligase HERC5 OS=Homo
sapiens GN=HERC5 PE=1 SV=2
Length = 1024
Score = 148 bits (373), Expect = 1e-034
Identities = 78/208 (37%), Positives = 125/208 (60%), Gaps = 3/208 (1%)
Frame = -3
Query: 1358 SALDEHQIVSVTCGADHTVAYSQSRSEVYSWGWGDFGRLGHGNS-SDLFTPLPIKALHGV 1182
S L E +I+ +TCG H++A S+ E+++WG G+LG G TP ++ L GV
Sbjct: 133 SILQEKKIIQITCGDYHSLALSKG-GELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGV 191
Query: 1181 RIKQIACGDSHCLAVTMEGEVQSWGRNQNGQLGLGDTEDSLVPRKIQAFEGIRIKMVAAG 1002
+ QI+ G++H +A++M G + SWG+N+ GQLGLG TE P I+ + +++ VA G
Sbjct: 192 PLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACG 251
Query: 1001 AEHTAAVTEDGDLYGWGWGRYGNLGLGDRNDRLVPERVTSAGAEKMSMVACGWRHTIS-V 825
H+A +T+DG L+ +G G++G LG + L P V +++ +ACG HT++ V
Sbjct: 252 GSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYV 311
Query: 824 SYSGALYTYGWSKYGQLGHGDLEDHLIP 741
S G ++++G K GQLG+G D L+P
Sbjct: 312 SDLGKVFSFGSGKDGQLGNGGTRDQLMP 339
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,472,851,095
Number of Sequences: 518415
Number of Extensions: 69472851095
Number of Successful Extensions: 496854919
Number of sequences better than 0.0: 0
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