BLASTX 7.6.2
Query= UN17450 /QuerySize=1179
(1178 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54Q31|PHB2_DICDI Prohibitin-2 OS=Dictyostelium discoideum GN... 329 3e-089
sp|Q5XIH7|PHB2_RAT Prohibitin-2 OS=Rattus norvegicus GN=Phb2 PE=... 300 1e-080
sp|Q99623|PHB2_HUMAN Prohibitin-2 OS=Homo sapiens GN=PHB2 PE=1 SV=2 300 2e-080
sp|O35129|PHB2_MOUSE Prohibitin-2 OS=Mus musculus GN=Phb2 PE=1 SV=1 300 2e-080
sp|P50085|PHB2_YEAST Prohibitin-2 OS=Saccharomyces cerevisiae GN... 299 3e-080
sp|Q2HJ97|PHB2_BOVIN Prohibitin-2 OS=Bos taurus GN=PHB2 PE=2 SV=1 299 3e-080
sp|Q5RB19|PHB2_PONAB Prohibitin-2 OS=Pongo abelii GN=PHB2 PE=2 SV=1 297 1e-079
sp|Q5ZMN3|PHB2_CHICK Prohibitin-2 OS=Gallus gallus GN=PHB2 PE=2 ... 296 3e-079
sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex protein 2 ... 295 5e-079
sp|A9UMS3|PHB2_XENTR Prohibitin-2 OS=Xenopus tropicalis GN=phb2 ... 295 7e-079
sp|O94550|PHB2_SCHPO Prohibitin-2 OS=Schizosaccharomyces pombe G... 293 2e-078
sp|Q54GI9|PHB1_DICDI Prohibitin-1, mitochondrial OS=Dictyosteliu... 276 2e-073
sp|P67778|PHB_MOUSE Prohibitin OS=Mus musculus GN=Phb PE=1 SV=1 272 6e-072
sp|P67779|PHB_RAT Prohibitin OS=Rattus norvegicus GN=Phb PE=1 SV=1 272 6e-072
sp|P40961|PHB1_YEAST Prohibitin-1 OS=Saccharomyces cerevisiae GN... 271 1e-071
sp|Q3T165|PHB_BOVIN Prohibitin OS=Bos taurus GN=PHB PE=2 SV=1 270 2e-071
sp|P35232|PHB_HUMAN Prohibitin OS=Homo sapiens GN=PHB PE=1 SV=1 270 2e-071
sp|P84173|PHB_CHICK Prohibitin OS=Gallus gallus GN=PHB PE=1 SV=1 268 5e-071
sp|P24156|L2CC_DROME Protein l(2)37Cc OS=Drosophila melanogaster... 262 4e-069
sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex protein 1 ... 261 1e-068
>sp|Q54Q31|PHB2_DICDI Prohibitin-2 OS=Dictyostelium discoideum GN=phbB PE=3
SV=1
Length = 293
Score = 329 bits (842), Expect = 3e-089
Identities = 175/294 (59%), Positives = 223/294 (75%), Gaps = 6/294 (2%)
Frame = -2
Query: 1114 KKKMNLNNV-KVPKVPGGGAVSALLKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGV 938
K ++N NN+ K+PK GG L +GG+GL A SL NV+GGHRAI+FNR VG+
Sbjct: 5 KFQVNFNNIPKLPKGSFGGGFGLL----ALGGVGLL-ALSSLVNVEGGHRAIVFNRFVGI 59
Query: 937 KDKVYPEGTHLMVPWFERPVIYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPE 758
K+KVY EGTH +VPWFER IYDVRA+P + S +GS+DLQMV I +RVL++P QLP
Sbjct: 60 KNKVYNEGTHFIVPWFERAEIYDVRAKPRSISSLTGSKDLQMVNITIRVLSKPKVSQLPA 119
Query: 757 IYRTLGENYSERVLPSIIHETLKAVVAQYNASQLITQREAVSREIRKILTQRATNFNIAL 578
IYRTLG++Y ERVLPSI++E LK++VAQ+NASQLITQRE VSR I K L RA +FNI L
Sbjct: 120 IYRTLGKDYDERVLPSIVNEILKSIVAQFNASQLITQREQVSRLIFKRLVDRAKDFNIEL 179
Query: 577 DDVSITTLTFGKEFTAAIEAKQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIG 398
DDVSIT L FG+E+ AAIEAKQVA QEAERA+F+VEKA QDKRS +++A+GEA+SAQLI
Sbjct: 180 DDVSITHLNFGREYAAAIEAKQVAQQEAERARFLVEKALQDKRSIIVKAEGEAQSAQLIN 239
Query: 397 QAIANNQAFITLRKIEAAREIAQTIAHSANKVYLSSDDLLLNLQKMNLDVDPKK 236
AI + + LR +EA++EIA ++ S NK+Y+S++ LLLN +N + PKK
Sbjct: 240 DAIKQSPYLVQLRTLEASKEIAHILSKSPNKLYISNETLLLNGFDLNNNQQPKK 293
>sp|Q5XIH7|PHB2_RAT Prohibitin-2 OS=Rattus norvegicus GN=Phb2 PE=1 SV=1
Length = 299
Score = 300 bits (768), Expect = 1e-080
Identities = 148/275 (53%), Positives = 214/275 (77%), Gaps = 3/275 (1%)
Frame = -2
Query: 1087 KVPKVPGGGAVSALLKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGV-KDKVYPEGT 911
++P P G + LK+ + G YG S++ V+GGHRAI FNR+ GV +D + EG
Sbjct: 11 RLPSGPRG--MGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGL 68
Query: 910 HLMVPWFERPVIYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENY 731
H +PWF+ P+IYD+RARP + S +GS+DLQMV I LRVL+RP A +LP +Y+ LG +Y
Sbjct: 69 HFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDY 128
Query: 730 SERVLPSIIHETLKAVVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLT 551
ERVLPSI++E LK+VVA++NASQLITQR VS IR+ LT+RA +F++ LDDV+IT L+
Sbjct: 129 EERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELS 188
Query: 550 FGKEFTAAIEAKQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAF 371
F +E+TAA+EAKQVA QEA+RA+F+VEKA+Q++R +++A+GEA++A+++G+A++ N +
Sbjct: 189 FSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGY 248
Query: 370 ITLRKIEAAREIAQTIAHSANKVYLSSDDLLLNLQ 266
I LRKI AA+ I++TIA S N++YL++D+L+LNLQ
Sbjct: 249 IKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQ 283
>sp|Q99623|PHB2_HUMAN Prohibitin-2 OS=Homo sapiens GN=PHB2 PE=1 SV=2
Length = 299
Score = 300 bits (767), Expect = 2e-080
Identities = 148/275 (53%), Positives = 214/275 (77%), Gaps = 3/275 (1%)
Frame = -2
Query: 1087 KVPKVPGGGAVSALLKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGV-KDKVYPEGT 911
++P P G + LK+ + G YG S++ V+GGHRAI FNR+ GV +D + EG
Sbjct: 11 RLPAGPRG--MGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGL 68
Query: 910 HLMVPWFERPVIYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENY 731
H +PWF+ P+IYD+RARP + S +GS+DLQMV I LRVL+RP A +LP +Y+ LG +Y
Sbjct: 69 HFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDY 128
Query: 730 SERVLPSIIHETLKAVVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLT 551
ERVLPSI++E LK+VVA++NASQLITQR VS IR+ LT+RA +F++ LDDV+IT L+
Sbjct: 129 EERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELS 188
Query: 550 FGKEFTAAIEAKQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAF 371
F +E+TAA+EAKQVA QEA+RA+F+VEKA+Q++R +++A+GEA++A+++G+A++ N +
Sbjct: 189 FSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGY 248
Query: 370 ITLRKIEAAREIAQTIAHSANKVYLSSDDLLLNLQ 266
I LRKI AA+ I++TIA S N++YL++D+L+LNLQ
Sbjct: 249 IKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQ 283
>sp|O35129|PHB2_MOUSE Prohibitin-2 OS=Mus musculus GN=Phb2 PE=1 SV=1
Length = 299
Score = 300 bits (767), Expect = 2e-080
Identities = 148/275 (53%), Positives = 214/275 (77%), Gaps = 3/275 (1%)
Frame = -2
Query: 1087 KVPKVPGGGAVSALLKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGV-KDKVYPEGT 911
++P P G + LK+ + G YG S++ V+GGHRAI FNR+ GV +D + EG
Sbjct: 11 RLPAGPRG--MGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGL 68
Query: 910 HLMVPWFERPVIYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENY 731
H +PWF+ P+IYD+RARP + S +GS+DLQMV I LRVL+RP A +LP +Y+ LG +Y
Sbjct: 69 HFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDY 128
Query: 730 SERVLPSIIHETLKAVVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLT 551
ERVLPSI++E LK+VVA++NASQLITQR VS IR+ LT+RA +F++ LDDV+IT L+
Sbjct: 129 EERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELS 188
Query: 550 FGKEFTAAIEAKQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAF 371
F +E+TAA+EAKQVA QEA+RA+F+VEKA+Q++R +++A+GEA++A+++G+A++ N +
Sbjct: 189 FSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGY 248
Query: 370 ITLRKIEAAREIAQTIAHSANKVYLSSDDLLLNLQ 266
I LRKI AA+ I++TIA S N++YL++D+L+LNLQ
Sbjct: 249 IKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQ 283
>sp|P50085|PHB2_YEAST Prohibitin-2 OS=Saccharomyces cerevisiae GN=PHB2 PE=1
SV=2
Length = 310
Score = 299 bits (765), Expect = 3e-080
Identities = 150/264 (56%), Positives = 207/264 (78%), Gaps = 1/264 (0%)
Frame = -2
Query: 1063 GAVSALLKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGVKDKVYPEGTHLMVPWFER 884
GA + L + ++GG L+ ++L+NVDGGHRAI+++R+ GV +++ EGTH + PW +
Sbjct: 36 GAFAGLGGLLLLGGGALF-INNALFNVDGGHRAIVYSRIHGVSSRIFNEGTHFIFPWLDT 94
Query: 883 PVIYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENYSERVLPSII 704
P+IYDVRA+P V S +G++DLQMV I RVL+RP QLP IYRTLG++Y ERVLPSI+
Sbjct: 95 PIIYDVRAKPRNVASLTGTKDLQMVNITCRVLSRPDVVQLPTIYRTLGQDYDERVLPSIV 154
Query: 703 HETLKAVVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLTFGKEFTAAI 524
+E LKAVVAQ+NASQLITQRE VSR IR+ L +RA+ FNI LDDVSIT +TF EFT A+
Sbjct: 155 NEVLKAVVAQFNASQLITQREKVSRLIRENLVRRASKFNILLDDVSITYMTFSPEFTNAV 214
Query: 523 EAKQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAFITLRKIEAA 344
EAKQ+A Q+A+RA F+V+KA Q+K+ V+RAQGEAKSA+LIG+AI ++ ++ L++++ A
Sbjct: 215 EAKQIAQQDAQRAAFVVDKARQEKQGMVVRAQGEAKSAELIGEAIKKSRDYVELKRLDTA 274
Query: 343 REIAQTIAHSANKVYLSSDDLLLN 272
R+IA+ +A S N+V L ++ LLLN
Sbjct: 275 RDIAKILASSPNRVILDNEALLLN 298
>sp|Q2HJ97|PHB2_BOVIN Prohibitin-2 OS=Bos taurus GN=PHB2 PE=2 SV=1
Length = 299
Score = 299 bits (764), Expect = 3e-080
Identities = 148/275 (53%), Positives = 214/275 (77%), Gaps = 3/275 (1%)
Frame = -2
Query: 1087 KVPKVPGGGAVSALLKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGV-KDKVYPEGT 911
++P P G + LK+ + G YG S++ V+GGHRAI FNR+ GV +D + EG
Sbjct: 11 RLPSGPRG--MGTALKLLLGAGAVAYGIRESVFTVEGGHRAIFFNRIGGVQQDTILAEGL 68
Query: 910 HLMVPWFERPVIYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENY 731
H +PWF+ P+IYD+RARP + S +GS+DLQMV I LRVL+RP A +LP +Y+ LG +Y
Sbjct: 69 HFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAMELPSMYQRLGLDY 128
Query: 730 SERVLPSIIHETLKAVVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLT 551
ERVLPSI++E LK+VVA++NASQLITQR VS IR+ LT+RA +F++ LDDV+IT L+
Sbjct: 129 EERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELS 188
Query: 550 FGKEFTAAIEAKQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAF 371
F +E+TAA+EAKQVA QEA+RA+F+VEKA+Q++R +++A+GEA++A+++G+A++ N +
Sbjct: 189 FSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAARMLGEALSKNPGY 248
Query: 370 ITLRKIEAAREIAQTIAHSANKVYLSSDDLLLNLQ 266
I LRKI AA+ I++TIA S N++YL++D+L+LNLQ
Sbjct: 249 IKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQ 283
>sp|Q5RB19|PHB2_PONAB Prohibitin-2 OS=Pongo abelii GN=PHB2 PE=2 SV=1
Length = 299
Score = 297 bits (760), Expect = 1e-079
Identities = 147/275 (53%), Positives = 213/275 (77%), Gaps = 3/275 (1%)
Frame = -2
Query: 1087 KVPKVPGGGAVSALLKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGV-KDKVYPEGT 911
++P P G + LK+ + G YG S++ V+GGHRAI FNR+ GV +D + EG
Sbjct: 11 RLPAGPRG--MGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGL 68
Query: 910 HLMVPWFERPVIYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENY 731
H +PWF+ P+IYD+RARP + S +GS+DLQMV I LRVL+RP A +LP +Y+ LG +Y
Sbjct: 69 HFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDY 128
Query: 730 SERVLPSIIHETLKAVVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLT 551
ERVLPSI++E LK+VVA++NASQLITQR VS IR+ LT+RA +F++ LDDV+IT L+
Sbjct: 129 EERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELS 188
Query: 550 FGKEFTAAIEAKQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAF 371
F +E+TAA+EAKQVA QEA+RA+F+VEKA+Q++R +++A+GEA++A+++G+A++ N +
Sbjct: 189 FSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGY 248
Query: 370 ITLRKIEAAREIAQTIAHSANKVYLSSDDLLLNLQ 266
I LRKI AA+ I++TIA S N++Y ++D+L+LNLQ
Sbjct: 249 IKLRKIRAAQNISKTIATSQNRIYPTADNLVLNLQ 283
>sp|Q5ZMN3|PHB2_CHICK Prohibitin-2 OS=Gallus gallus GN=PHB2 PE=2 SV=1
Length = 301
Score = 296 bits (756), Expect = 3e-079
Identities = 149/275 (54%), Positives = 212/275 (77%), Gaps = 3/275 (1%)
Frame = -2
Query: 1087 KVPKVPGGGAVSALLKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGV-KDKVYPEGT 911
++P P G V LK+ + G YG S++ V+GG RAI FNR+ GV +D + EG
Sbjct: 11 RLPAGPRG--VGTALKLLLGAGALAYGVRESVFIVEGGQRAIFFNRIGGVQQDTILAEGL 68
Query: 910 HLMVPWFERPVIYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENY 731
H +PWF+ P+IYD+RARP + S +GS+DLQMV I LRVLTRP A +LP +Y+ LG +Y
Sbjct: 69 HFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLTRPNAAELPSMYQRLGLDY 128
Query: 730 SERVLPSIIHETLKAVVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLT 551
ERVLPSI++E LK+VVA++NASQLITQR VS IR+ LT+RA +F++ LDDV+IT L+
Sbjct: 129 EERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELS 188
Query: 550 FGKEFTAAIEAKQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAF 371
F +E+TAA+EAKQVA QEA+RA+F+VEKA+Q+++ +++A+GEA +A+++G+A++ N +
Sbjct: 189 FSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQKQKIVQAEGEATAAKMLGEALSRNPGY 248
Query: 370 ITLRKIEAAREIAQTIAHSANKVYLSSDDLLLNLQ 266
I LRKI AA+ I++TIA S N+VYL++D+L+LNLQ
Sbjct: 249 IKLRKIRAAQNISKTIAGSQNRVYLTADNLVLNLQ 283
>sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex protein 2
OS=Caenorhabditis elegans GN=phb-2 PE=1 SV=2
Length = 294
Score = 295 bits (754), Expect = 5e-079
Identities = 141/252 (55%), Positives = 194/252 (76%)
Frame = -2
Query: 1024 GLGLYGATHSLYNVDGGHRAIMFNRLVGVKDKVYPEGTHLMVPWFERPVIYDVRARPYLV 845
G +YG S++ V+ GHRAIMFNR+ G+ +Y EG H +PWF+ P+IYD+RARP +
Sbjct: 30 GAAVYGVAQSMFTVEAGHRAIMFNRIGGLSTDLYKEGLHFRIPWFQYPIIYDIRARPNQI 89
Query: 844 ESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENYSERVLPSIIHETLKAVVAQYNA 665
S +GS+DLQMV IGLRVL+RP + L IYRTLG+N+ ERVLPSI +E LK VVA++NA
Sbjct: 90 RSPTGSKDLQMVNIGLRVLSRPNPEHLVHIYRTLGQNWEERVLPSICNEVLKGVVAKFNA 149
Query: 664 SQLITQREAVSREIRKILTQRATNFNIALDDVSITTLTFGKEFTAAIEAKQVAAQEAERA 485
SQLITQR+ VS +RK L +RA +FNI LDDVS+T L F +++AA+EAKQVAAQEA+RA
Sbjct: 150 SQLITQRQQVSMLVRKTLIERALDFNIILDDVSLTELAFSPQYSAAVEAKQVAAQEAQRA 209
Query: 484 KFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAFITLRKIEAAREIAQTIAHSANK 305
F VE+A+Q K+ +++A+GEA+SA+L+G+A+ N+ F+ LRKI AA++IA+ ++ S NK
Sbjct: 210 TFYVERAKQQKQEKIVQAEGEAESAKLLGEAMKNDPGFLKLRKIRAAQKIARIVSESGNK 269
Query: 304 VYLSSDDLLLNL 269
YL + L+LN+
Sbjct: 270 TYLPTGGLMLNI 281
>sp|A9UMS3|PHB2_XENTR Prohibitin-2 OS=Xenopus tropicalis GN=phb2 PE=2 SV=1
Length = 301
Score = 295 bits (753), Expect = 7e-079
Identities = 148/275 (53%), Positives = 209/275 (76%), Gaps = 3/275 (1%)
Frame = -2
Query: 1087 KVPKVPGGGAVSALLKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGV-KDKVYPEGT 911
++P P G + L +G G Y S++ V+GGHRAI FNR+ GV +D + EG
Sbjct: 11 RLPAGPRGMGTAMKLLLG--AGAVAYAVKESVFTVEGGHRAIFFNRIGGVQQDTILAEGL 68
Query: 910 HLMVPWFERPVIYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENY 731
H PWF+ P+IYD+RARP + S +GS+DLQMV I LRVL+RP+A +LP +Y+ LG +Y
Sbjct: 69 HFRFPWFQYPIIYDIRARPRKISSPTGSKDLQMVNITLRVLSRPLASELPFMYQRLGLDY 128
Query: 730 SERVLPSIIHETLKAVVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLT 551
ERVLPSI++E LK+VVA++NASQLITQR VS IR+ LT+RA +F+I LDDV+IT L+
Sbjct: 129 DERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSIILDDVAITELS 188
Query: 550 FGKEFTAAIEAKQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAF 371
F +E+TAA+E+KQVA QEA+RA+F+VEKA+QD++ +++A+GEA +A++IG A++ N +
Sbjct: 189 FSREYTAAVESKQVAQQEAQRAQFLVEKAKQDQKQKIVQAEGEAAAAKMIGDALSKNPGY 248
Query: 370 ITLRKIEAAREIAQTIAHSANKVYLSSDDLLLNLQ 266
+ LR+I AA+ IA+TIA S N+VYL++D L+LNLQ
Sbjct: 249 LKLRRIRAAQSIAKTIASSQNRVYLNADSLVLNLQ 283
>sp|O94550|PHB2_SCHPO Prohibitin-2 OS=Schizosaccharomyces pombe GN=phb2 PE=2
SV=1
Length = 279
Score = 293 bits (748), Expect = 2e-078
Identities = 147/257 (57%), Positives = 195/257 (75%), Gaps = 2/257 (0%)
Frame = -2
Query: 1036 GIIGGLGLYG--ATHSLYNVDGGHRAIMFNRLVGVKDKVYPEGTHLMVPWFERPVIYDVR 863
G++ LGL G SL+NVDGGHRAI ++R+ G+K+ +YPEGTH ++PW E + YDVR
Sbjct: 20 GLLLALGLAGFAVQTSLFNVDGGHRAIKYSRIGGIKNLIYPEGTHFLIPWIETAIDYDVR 79
Query: 862 ARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENYSERVLPSIIHETLKAV 683
A+P + S +G++DLQMV I RVL+RP LP+IYRTLG +Y ERVLPSI++E LK+V
Sbjct: 80 AKPRNISSLTGTKDLQMVNINCRVLSRPDVHALPKIYRTLGGDYDERVLPSIVNEVLKSV 139
Query: 682 VAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLTFGKEFTAAIEAKQVAA 503
VAQ+NASQLITQRE VSR +R+ L +RA FNI LDDVS+T + F EFTAA+EAKQ+A
Sbjct: 140 VAQFNASQLITQRERVSRLVRENLMKRAARFNILLDDVSLTHVQFSPEFTAAVEAKQIAQ 199
Query: 502 QEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAFITLRKIEAAREIAQTI 323
Q+A+RA F V++A +K+ ++RAQGE ++AQLIG+AI N FI LRK+E AREIA +
Sbjct: 200 QDAQRATFYVDRARMEKQGFIVRAQGEGRAAQLIGEAIKNKPGFIELRKLETAREIANIL 259
Query: 322 AHSANKVYLSSDDLLLN 272
+ S NKV L++ LLL+
Sbjct: 260 SKSNNKVMLNASTLLLD 276
>sp|Q54GI9|PHB1_DICDI Prohibitin-1, mitochondrial OS=Dictyostelium discoideum
GN=phbA PE=3 SV=1
Length = 271
Score = 276 bits (705), Expect = 2e-073
Identities = 138/266 (51%), Positives = 203/266 (76%), Gaps = 1/266 (0%)
Frame = -2
Query: 1057 VSALLKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGVKDKVYPEGTHLMVPWFERPV 878
++ L+ + + G GL A S+Y VDGG RA++F+R+ GVK+K EGTH ++PW ++P+
Sbjct: 5 LNKLIPLALTVGTGLSLAQSSMYTVDGGQRAVIFDRISGVKEKSVGEGTHFIMPWLQKPI 64
Query: 877 IYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENYSERVLPSIIHE 698
I+D+R+ P ++S +GS+DLQ V + +RVL RP + LP I+ LG +Y ER+LPS+ +E
Sbjct: 65 IFDIRSSPRNIKSDTGSKDLQTVSVTVRVLFRPDVEHLPSIFSKLGLDYDERILPSLGNE 124
Query: 697 TLKAVVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLTFGKEFTAAIEA 518
LK+VVAQY+A++LITQRE VS+EIR+ L +RA FN+ LDDVSIT L+F ++FT AIE
Sbjct: 125 VLKSVVAQYDATELITQREVVSKEIRESLMKRAKEFNLLLDDVSITHLSFSQDFTNAIEH 184
Query: 517 KQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAFITLRKIEAARE 338
KQVA QEAER+K+IV K EQ+K++ +IRA+GEA++A+LIGQA+ N+ AFI LR+IEA ++
Sbjct: 185 KQVAQQEAERSKYIVMKNEQEKKANIIRAEGEAEAAKLIGQAMGNSAAFIELRRIEAYKD 244
Query: 337 IAQTIAHSANKVYL-SSDDLLLNLQK 263
I ++++ S Y+ +S +LL+NL K
Sbjct: 245 ITESLSKSKQVTYVPTSGNLLMNLNK 270
>sp|P67778|PHB_MOUSE Prohibitin OS=Mus musculus GN=Phb PE=1 SV=1
Length = 272
Score = 272 bits (693), Expect = 6e-072
Identities = 138/258 (53%), Positives = 189/258 (73%), Gaps = 5/258 (1%)
Frame = -2
Query: 1045 LKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGVKDKVYPEGTHLMVPWFERPVIYDV 866
L + + GG+ +LYNVD GHRA++F+R GV+D V EGTH ++PW ++P+I+D
Sbjct: 14 LALAVAGGV----VNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDC 69
Query: 865 RARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENYSERVLPSIIHETLKA 686
R+RP V +GS+DLQ V I LR+L RP+A QLP IY ++GE+Y ERVLPSI E LK+
Sbjct: 70 RSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLPSITTEILKS 129
Query: 685 VVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLTFGKEFTAAIEAKQVA 506
VVA+++A +LITQRE VSR++ LT+RA F + LDDVS+T LTFGKEFT A+EAKQVA
Sbjct: 130 VVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVA 189
Query: 505 AQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIAN-NQAFITLRKIEAAREIAQ 329
QEAERA+F+VEKAEQ K++A+I A+G++K+A+LI ++A I LRK+EAA +IA
Sbjct: 190 QQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAY 249
Query: 328 TIAHSANKVYLSSDDLLL 275
++ S N YL + +L
Sbjct: 250 QLSRSRNITYLPAGQSVL 267
>sp|P67779|PHB_RAT Prohibitin OS=Rattus norvegicus GN=Phb PE=1 SV=1
Length = 272
Score = 272 bits (693), Expect = 6e-072
Identities = 138/258 (53%), Positives = 189/258 (73%), Gaps = 5/258 (1%)
Frame = -2
Query: 1045 LKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGVKDKVYPEGTHLMVPWFERPVIYDV 866
L + + GG+ +LYNVD GHRA++F+R GV+D V EGTH ++PW ++P+I+D
Sbjct: 14 LALAVAGGV----VNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDC 69
Query: 865 RARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENYSERVLPSIIHETLKA 686
R+RP V +GS+DLQ V I LR+L RP+A QLP IY ++GE+Y ERVLPSI E LK+
Sbjct: 70 RSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLPSITTEILKS 129
Query: 685 VVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLTFGKEFTAAIEAKQVA 506
VVA+++A +LITQRE VSR++ LT+RA F + LDDVS+T LTFGKEFT A+EAKQVA
Sbjct: 130 VVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVA 189
Query: 505 AQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIAN-NQAFITLRKIEAAREIAQ 329
QEAERA+F+VEKAEQ K++A+I A+G++K+A+LI ++A I LRK+EAA +IA
Sbjct: 190 QQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAY 249
Query: 328 TIAHSANKVYLSSDDLLL 275
++ S N YL + +L
Sbjct: 250 QLSRSRNITYLPAGQSVL 267
>sp|P40961|PHB1_YEAST Prohibitin-1 OS=Saccharomyces cerevisiae GN=PHB1 PE=1
SV=2
Length = 287
Score = 271 bits (691), Expect = 1e-071
Identities = 133/257 (51%), Positives = 196/257 (76%), Gaps = 1/257 (0%)
Frame = -2
Query: 1057 VSALLKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGVKDKVYPEGTHLMVPWFERPV 878
+ + K+ + G+ G +S+Y+V GG R ++F+R+ GVK +V EGTH +VPW ++ +
Sbjct: 8 IDVITKVALPIGIIASGIQYSMYDVKGGSRGVIFDRINGVKQQVVGEGTHFLVPWLQKAI 67
Query: 877 IYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENYSERVLPSIIHE 698
IYDVR +P + + +G++DLQMV + LRVL RP QLP IY+ LG +Y ERVLPSI +E
Sbjct: 68 IYDVRTKPKSIATNTGTKDLQMVSLTLRVLHRPEVLQLPAIYQNLGLDYDERVLPSIGNE 127
Query: 697 TLKAVVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLTFGKEFTAAIEA 518
LK++VAQ++A++LITQRE +S++IRK L+ RA F I L+DVSIT +TFG EFT A+E
Sbjct: 128 VLKSIVAQFDAAELITQREIISQKIRKELSTRANEFGIKLEDVSITHMTFGPEFTKAVEQ 187
Query: 517 KQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIAN-NQAFITLRKIEAAR 341
KQ+A Q+AERAKF+VEKAEQ+++++VIRA+GEA+SA+ I +A+A + +R++EA++
Sbjct: 188 KQIAQQDAERAKFLVEKAEQERQASVIRAEGEAESAEFISKALAKVGDGLLLIRRLEASK 247
Query: 340 EIAQTIAHSANKVYLSS 290
+IAQT+A+S+N VYL S
Sbjct: 248 DIAQTLANSSNVVYLPS 264
>sp|Q3T165|PHB_BOVIN Prohibitin OS=Bos taurus GN=PHB PE=2 SV=1
Length = 272
Score = 270 bits (689), Expect = 2e-071
Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 5/258 (1%)
Frame = -2
Query: 1045 LKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGVKDKVYPEGTHLMVPWFERPVIYDV 866
L + + GG+ +LYNVD GHRA++F+R GV+D V EGTH ++PW ++P+I+D
Sbjct: 14 LALAVAGGV----VNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDC 69
Query: 865 RARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENYSERVLPSIIHETLKA 686
R+RP V +GS+DLQ V I LR+L RP+A QLP I+ ++GE+Y ERVLPSI E LK+
Sbjct: 70 RSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKS 129
Query: 685 VVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLTFGKEFTAAIEAKQVA 506
VVA+++A +LITQRE VSR++ LT+RA F + LDDVS+T LTFGKEFT A+EAKQVA
Sbjct: 130 VVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVA 189
Query: 505 AQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIAN-NQAFITLRKIEAAREIAQ 329
QEAERA+F+VEKAEQ K++A+I A+G++K+A+LI ++A I LRK+EAA +IA
Sbjct: 190 QQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAY 249
Query: 328 TIAHSANKVYLSSDDLLL 275
++ S N YL + +L
Sbjct: 250 QLSRSRNITYLPAGQSVL 267
>sp|P35232|PHB_HUMAN Prohibitin OS=Homo sapiens GN=PHB PE=1 SV=1
Length = 272
Score = 270 bits (689), Expect = 2e-071
Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 5/258 (1%)
Frame = -2
Query: 1045 LKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGVKDKVYPEGTHLMVPWFERPVIYDV 866
L + + GG+ +LYNVD GHRA++F+R GV+D V EGTH ++PW ++P+I+D
Sbjct: 14 LALAVAGGV----VNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDC 69
Query: 865 RARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENYSERVLPSIIHETLKA 686
R+RP V +GS+DLQ V I LR+L RP+A QLP I+ ++GE+Y ERVLPSI E LK+
Sbjct: 70 RSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKS 129
Query: 685 VVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLTFGKEFTAAIEAKQVA 506
VVA+++A +LITQRE VSR++ LT+RA F + LDDVS+T LTFGKEFT A+EAKQVA
Sbjct: 130 VVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVA 189
Query: 505 AQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIAN-NQAFITLRKIEAAREIAQ 329
QEAERA+F+VEKAEQ K++A+I A+G++K+A+LI ++A I LRK+EAA +IA
Sbjct: 190 QQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAY 249
Query: 328 TIAHSANKVYLSSDDLLL 275
++ S N YL + +L
Sbjct: 250 QLSRSRNITYLPAGQSVL 267
>sp|P84173|PHB_CHICK Prohibitin OS=Gallus gallus GN=PHB PE=1 SV=1
Length = 272
Score = 268 bits (685), Expect = 5e-071
Identities = 137/258 (53%), Positives = 188/258 (72%), Gaps = 5/258 (1%)
Frame = -2
Query: 1045 LKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGVKDKVYPEGTHLMVPWFERPVIYDV 866
L + + GG+ +LYNVD GHRA++F+R GV+D V EGTH ++PW ++P+I+D
Sbjct: 14 LGLAVAGGV----VNSALYNVDAGHRAVIFDRFRGVQDTVVGEGTHFLIPWVQKPIIFDC 69
Query: 865 RARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENYSERVLPSIIHETLKA 686
R+RP + +GS+DLQ V I LR+L RP+ QLP I+ ++GE+Y ERVLPSI E LK+
Sbjct: 70 RSRPRNIPVITGSKDLQNVNITLRILFRPVTAQLPRIFTSIGEDYDERVLPSITTEILKS 129
Query: 685 VVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLTFGKEFTAAIEAKQVA 506
VVA+++A +LITQRE VSR++ + LT+RA F + LDDVS+T LTFGKEFT A+E KQVA
Sbjct: 130 VVARFDAGELITQRELVSRQVSEDLTERAATFGLILDDVSLTHLTFGKEFTEAVEMKQVA 189
Query: 505 AQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIAN-NQAFITLRKIEAAREIAQ 329
QEAERA+FIVEKAEQ K++AVI A+G++K+A+LI ++A I LRK+EAA +IA
Sbjct: 190 QQEAERARFIVEKAEQQKKAAVISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAY 249
Query: 328 TIAHSANKVYLSSDDLLL 275
++ S N YL S +L
Sbjct: 250 QLSRSRNITYLPSGQSVL 267
>sp|P24156|L2CC_DROME Protein l(2)37Cc OS=Drosophila melanogaster GN=l(2)37Cc
PE=1 SV=2
Length = 276
Score = 262 bits (669), Expect = 4e-069
Identities = 133/261 (50%), Positives = 186/261 (71%), Gaps = 6/261 (2%)
Frame = -2
Query: 1045 LKIGIIGGLGLYGATHSLYNVDGGHRAIMFNRLVGVKDKVYPEGTHLMVPWFERPVIYDV 866
L + ++GG+ +LYNV+GGHRA++F+R G+K+ V EGTH +PW +RP+I+D+
Sbjct: 14 LGVAVLGGV----VNSALYNVEGGHRAVIFDRFTGIKENVVGEGTHFFIPWVQRPIIFDI 69
Query: 865 RARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENYSERVLPSIIHETLKA 686
R++P V +GS+DLQ V I LR+L RP+ DQLP+IY LG++Y ERVLPSI E LKA
Sbjct: 70 RSQPRNVPVITGSKDLQNVNITLRILYRPIPDQLPKIYTILGQDYDERVLPSIAPEVLKA 129
Query: 685 VVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLTFGKEFTAAIEAKQVA 506
VVAQ++A +LITQRE VS+ + + LT RA F LDD+S+T LTFG+EFT A+E KQVA
Sbjct: 130 VVAQFDAGELITQREMVSQRVSQELTVRAKQFGFILDDISLTHLTFGREFTLAVEMKQVA 189
Query: 505 AQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIAN-NQAFITLRKIEAAREIAQ 329
QEAE+A+F+VEKAEQ K +++I A+G+A++A L+ ++ + LR+IEAA +IA
Sbjct: 190 QQEAEKARFVVEKAEQQKLASIISAEGDAEAAGLLAKSFGEAGDGLVELRRIEAAEDIAY 249
Query: 328 TIAHSANKVYL-SSDDLLLNL 269
++ S YL S LLNL
Sbjct: 250 QLSRSRGVAYLPSGQSTLLNL 270
>sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex protein 1
OS=Caenorhabditis elegans GN=phb-1 PE=1 SV=1
Length = 275
Score = 261 bits (665), Expect = 1e-068
Identities = 138/270 (51%), Positives = 194/270 (71%), Gaps = 5/270 (1%)
Frame = -2
Query: 1060 AVSALLKIGIIG-GLGLYG--ATHSLYNVDGGHRAIMFNRLVGVKDKVYPEGTHLMVPWF 890
A L ++G +G GL + G A +LYNVDGG RA++F+R GVK++V EGTH ++PW
Sbjct: 5 AQKLLGRLGTVGVGLSIAGGIAQTALYNVDGGQRAVIFDRFSGVKNEVVGEGTHFLIPWV 64
Query: 889 ERPVIYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRTLGENYSERVLPS 710
++P+I+D+R+ P V + +GS+DLQ V I LR+L RP D+LP IY +G +Y+ERVLPS
Sbjct: 65 QKPIIFDIRSTPRAVTTITGSKDLQNVNITLRILHRPSPDRLPNIYLNIGLDYAERVLPS 124
Query: 709 IIHETLKAVVAQYNASQLITQREAVSREIRKILTQRATNFNIALDDVSITTLTFGKEFTA 530
I +E LKAVVAQ++A ++ITQRE VS+ L +RA F + LDD++IT L FG+EFT
Sbjct: 125 ITNEVLKAVVAQFDAHEMITQREVVSQRASVALRERAAQFGLLLDDIAITHLNFGREFTE 184
Query: 529 AIEAKQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIAN-NQAFITLRKI 353
A+E KQVA QEAE+A+++VEKAEQ K +AV A+G+A++A+L+ +A A+ + LRKI
Sbjct: 185 AVEMKQVAQQEAEKARYLVEKAEQMKIAAVTTAEGDAQAAKLLAKAFASAGDGLVELRKI 244
Query: 352 EAAREIAQTIAHSANKVYL-SSDDLLLNLQ 266
EAA EIA+ +A + N YL + LLNLQ
Sbjct: 245 EAAEEIAERMAKNKNVTYLPGNQQTLLNLQ 274
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,471,325,924
Number of Sequences: 518415
Number of Extensions: 72471325924
Number of Successful Extensions: 505334272
Number of sequences better than 0.0: 0
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