BLASTX 7.6.2
Query= UN17559 /QuerySize=1117
(1116 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q03529|SCS7_YEAST Ceramide very long chain fatty acid hydroxy... 161 1e-038
sp|O13846|SCS7_SCHPO Ceramide very long chain fatty acid hydroxy... 141 1e-032
sp|Q4R4P4|FA2H_MACFA Fatty acid 2-hydroxylase OS=Macaca fascicul... 118 1e-025
sp|Q2LAM0|FA2H_RAT Fatty acid 2-hydroxylase OS=Rattus norvegicus... 117 1e-025
sp|Q7L5A8|FA2H_HUMAN Fatty acid 2-hydroxylase OS=Homo sapiens GN... 116 3e-025
sp|Q5MPP0|FA2H_MOUSE Fatty acid 2-hydroxylase OS=Mus musculus GN... 112 4e-024
>sp|Q03529|SCS7_YEAST Ceramide very long chain fatty acid hydroxylase SCS7
OS=Saccharomyces cerevisiae GN=SCS7 PE=1 SV=1
Length = 384
Score = 161 bits (406), Expect = 1e-038
Identities = 87/207 (42%), Positives = 117/207 (56%), Gaps = 8/207 (3%)
Frame = +2
Query: 167 VDLDKPLVFQV---GHLGEEYQEWIHQPIVCVEGPRFFQSDFWEFLTRTVWWAIPTIWLP 337
+DL++PL+ Q+ + Y + IH+P +G +F E LT+T WW +P WLP
Sbjct: 148 LDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLP 207
Query: 338 VVCYVLSISAARGLTFPQMGLIVAFGVFTWTLLEYTLHRFLFHIE---TKSYWANTAHYL 508
VV Y + + A + + + GVF WTL+EY LHRFLFH + +S A H+L
Sbjct: 208 VVVYHMGV-ALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFL 266
Query: 509 LHGCHHKHPQDGLRLVFPPTATAILLVPLWKLLHLIATPATAPAMLGGILFGYVMYDCTH 688
LHGCHH P D RLV PPT IL P +KL+ + A A G LFGYV YD H
Sbjct: 267 LHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECH 326
Query: 689 FYLHHGQPKEPTFKHLKKYHLNHHFRS 769
F+LHH + P + LKKYHL HH+++
Sbjct: 327 FFLHHSK-LPPFMRKLKKYHLEHHYKN 352
>sp|O13846|SCS7_SCHPO Ceramide very long chain fatty acid hydroxylase-like
protein C19G12.08 OS=Schizosaccharomyces pombe GN=SPAC19G12.08 PE=2
SV=1
Length = 347
Score = 141 bits (353), Expect = 1e-032
Identities = 78/209 (37%), Positives = 112/209 (53%), Gaps = 12/209 (5%)
Frame = +2
Query: 167 VDLDKPLVFQV--GHLGEE-YQEWIHQP-IVCVEGPRFFQSDFWEFLTRTVWWAIPTIWL 334
+DL KPL+ Q+ G++ ++ Y + +H+P G +F E LT+T W+ IP IW+
Sbjct: 107 LDLKKPLLPQILFGNIKKDVYLDQVHRPRHYRGSGSAPLFGNFLEPLTKTPWYMIPLIWV 166
Query: 335 PVVCYVLSISAARGLTFPQMGLIVAFGVFTWTLLEYTLHRFLFHIETKSYWAN-----TA 499
P V Y + A G+ F G+FTWTL+EYT+HRFLFH++ Y + T
Sbjct: 167 PCVTYGF-LYACTGIPFSVAITFFIIGLFTWTLVEYTMHRFLFHLD--EYTPDHPIFLTM 223
Query: 500 HYLLHGCHHKHPQDGLRLVFPPTATAILLVPLWKLLHLIATPATAPAMLGGILFGYVMYD 679
H+ HGCHH P D RLV PP I P + + L+ A G + GYV YD
Sbjct: 224 HFAFHGCHHFLPADKYRLVMPPALFLIFATPWYHFIQLVLPHYIGVAGFSGAILGYVFYD 283
Query: 680 CTHFYLHHGQPKEPTFKHLKKYHLNHHFR 766
TH++LHH + LK +HL+HH++
Sbjct: 284 LTHYFLHHRRMPNAYLTDLKTWHLDHHYK 312
>sp|Q4R4P4|FA2H_MACFA Fatty acid 2-hydroxylase OS=Macaca fascicularis GN=FA2H
PE=2 SV=1
Length = 372
Score = 118 bits (294), Expect = 1e-025
Identities = 53/120 (44%), Positives = 77/120 (64%), Gaps = 3/120 (2%)
Frame = +2
Query: 413 GVFTWTLLEYTLHRFLFHIE--TKSYWANTAHYLLHGCHHKHPQDGLRLVFPPTATAILL 586
G+F W+L+EY +HRFLFH++ + SY+ H+++HG HHK P DG RLVFPP ++++
Sbjct: 222 GIFLWSLIEYLIHRFLFHMKPPSDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVI 281
Query: 587 VPLWKLLHLIATPATAPAMLGGILFGYVMYDCTHFYLHHGQPKEPTFKH-LKKYHLNHHF 763
+ L LI A + G L GYV+YD TH+YLH G P ++ + LK +H+ HHF
Sbjct: 282 GVFYLCLQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHRGSYLYNLKAHHVKHHF 341
Score = 79 bits (192), Expect = 7e-014
Identities = 44/86 (51%), Positives = 57/86 (66%), Gaps = 6/86 (6%)
Frame = +2
Query: 167 VDLDKPLVFQVGHLGEEYQEWIHQPIVCVEGPRFFQSDFWEFLTRTVWWAIPTIWLPVVC 346
VD KPL++QVGHLGE+Y EW+HQP+ R F SD E L++TVW+++P IW+P+V
Sbjct: 124 VDWQKPLLWQVGHLGEKYDEWVHQPV--TRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVL 181
Query: 347 YVLSISAARGLTFPQMGLIVAFGVFT 424
Y LS S R TF Q G + F FT
Sbjct: 182 Y-LSWSYYR--TFAQ-GNVRLFTSFT 203
>sp|Q2LAM0|FA2H_RAT Fatty acid 2-hydroxylase OS=Rattus norvegicus GN=Fa2h PE=1
SV=2
Length = 372
Score = 117 bits (293), Expect = 1e-025
Identities = 55/127 (43%), Positives = 82/127 (64%), Gaps = 4/127 (3%)
Frame = +2
Query: 392 MGLIVAFGVFTWTLLEYTLHRFLFHIE--TKSYWANTAHYLLHGCHHKHPQDGLRLVFPP 565
+GL V G+ WTL+EY +HRFLFH++ + S++ H+++HG HHK P DG RLVFPP
Sbjct: 216 IGLFV-LGMLIWTLVEYLIHRFLFHMKPPSNSHYLIMLHFVMHGQHHKAPFDGSRLVFPP 274
Query: 566 TATAILLVPLWKLLHLIATPATAPAMLGGILFGYVMYDCTHFYLHHGQPKEPTFKH-LKK 742
++++ + L LI A A + G L GYV+YD TH+YLH G P + ++ + +K
Sbjct: 275 VPASVVVAFFYVFLRLILPEAVAGILFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYNMKA 334
Query: 743 YHLNHHF 763
+H+ HHF
Sbjct: 335 HHVKHHF 341
Score = 80 bits (197), Expect = 2e-014
Identities = 40/82 (48%), Positives = 54/82 (65%), Gaps = 3/82 (3%)
Frame = +2
Query: 167 VDLDKPLVFQVGHLGEEYQEWIHQPIVCVEGPRFFQSDFWEFLTRTVWWAIPTIWLPVVC 346
VD KPL++QVGHLGE+Y EW+HQP+ R F SD E ++TVW+++P IW+P+V
Sbjct: 124 VDWQKPLLWQVGHLGEKYDEWVHQPV--ARPIRLFHSDLIEAFSKTVWYSVPIIWVPLVL 181
Query: 347 YVLSISAARGLTFPQMGLIVAF 412
Y LS S R LT + L +F
Sbjct: 182 Y-LSWSYYRTLTQDNIRLFASF 202
>sp|Q7L5A8|FA2H_HUMAN Fatty acid 2-hydroxylase OS=Homo sapiens GN=FA2H PE=1
SV=1
Length = 372
Score = 116 bits (290), Expect = 3e-025
Identities = 52/120 (43%), Positives = 77/120 (64%), Gaps = 3/120 (2%)
Frame = +2
Query: 413 GVFTWTLLEYTLHRFLFHIE--TKSYWANTAHYLLHGCHHKHPQDGLRLVFPPTATAILL 586
G F W+L+EY +HRFLFH++ + SY+ H+++HG HHK P DG RLVFPP ++++
Sbjct: 222 GTFLWSLIEYLIHRFLFHMKPPSDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVI 281
Query: 587 VPLWKLLHLIATPATAPAMLGGILFGYVMYDCTHFYLHHGQPKEPTFKH-LKKYHLNHHF 763
+ + LI A + G L GYV+YD TH+YLH G P + ++ + LK +H+ HHF
Sbjct: 282 GVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHF 341
Score = 82 bits (200), Expect = 8e-015
Identities = 50/132 (37%), Positives = 72/132 (54%), Gaps = 7/132 (5%)
Frame = +2
Query: 167 VDLDKPLVFQVGHLGEEYQEWIHQPIVCVEGPRFFQSDFWEFLTRTVWWAIPTIWLPVVC 346
VD KPL++QVGHLGE+Y EW+HQP+ R F SD E L++TVW+++P IW+P+V
Sbjct: 124 VDWRKPLLWQVGHLGEKYDEWVHQPV--TRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVL 181
Query: 347 YVLSISAARGLTFPQMGLIVAFGVFTWTLLEYTLHRFLFHIETKSYWANTAHYLLHG--C 520
Y LS S R + L +F + ++ LF + T + + YL+H
Sbjct: 182 Y-LSWSYYRTFAQGNVRLFTSFTTEYTVAVPKSMFPGLFMLGT--FLWSLIEYLIHRFLF 238
Query: 521 HHKHPQDGLRLV 556
H K P D L+
Sbjct: 239 HMKPPSDSYYLI 250
>sp|Q5MPP0|FA2H_MOUSE Fatty acid 2-hydroxylase OS=Mus musculus GN=Fa2h PE=1
SV=1
Length = 372
Score = 112 bits (280), Expect = 4e-024
Identities = 52/127 (40%), Positives = 79/127 (62%), Gaps = 4/127 (3%)
Frame = +2
Query: 392 MGLIVAFGVFTWTLLEYTLHRFLFHIE--TKSYWANTAHYLLHGCHHKHPQDGLRLVFPP 565
+GL V G+ WT +EY +HRFLFH++ + S++ H+++HG HHK P DG RLVFPP
Sbjct: 216 IGLFV-LGMLFWTFVEYVIHRFLFHMKPPSNSHYLIMLHFVMHGQHHKAPFDGSRLVFPP 274
Query: 566 TATAILLVPLWKLLHLIATPATAPAMLGGILFGYVMYDCTHFYLHHGQPKEPTFKH-LKK 742
++++ + L LI + G L GYV+YD TH+YLH G P + ++ + +K
Sbjct: 275 VPASLVIAFFYVFLRLILPETVGGIIFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYNMKA 334
Query: 743 YHLNHHF 763
+H+ HHF
Sbjct: 335 HHVKHHF 341
Score = 78 bits (191), Expect = 9e-014
Identities = 38/72 (52%), Positives = 50/72 (69%), Gaps = 3/72 (4%)
Frame = +2
Query: 167 VDLDKPLVFQVGHLGEEYQEWIHQPIVCVEGPRFFQSDFWEFLTRTVWWAIPTIWLPVVC 346
VD KPL++QVGHLGE+Y EW+HQP+ R F SD E ++TVW+++P IW+P+V
Sbjct: 124 VDWQKPLLWQVGHLGEKYDEWVHQPV--ARPIRLFHSDLIEAFSKTVWYSVPIIWVPLVL 181
Query: 347 YVLSISAARGLT 382
Y LS S R LT
Sbjct: 182 Y-LSWSYYRTLT 192
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,471,325,924
Number of Sequences: 518415
Number of Extensions: 72471325924
Number of Successful Extensions: 505334272
Number of sequences better than 0.0: 0
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