BLASTX 7.6.2
Query= UN17602 /QuerySize=1050
(1049 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q03529|SCS7_YEAST Ceramide very long chain fatty acid hydroxy... 181 9e-045
sp|O13846|SCS7_SCHPO Ceramide very long chain fatty acid hydroxy... 161 7e-039
sp|Q2LAM0|FA2H_RAT Fatty acid 2-hydroxylase OS=Rattus norvegicus... 136 3e-031
sp|Q4R4P4|FA2H_MACFA Fatty acid 2-hydroxylase OS=Macaca fascicul... 135 6e-031
sp|Q7L5A8|FA2H_HUMAN Fatty acid 2-hydroxylase OS=Homo sapiens GN... 134 2e-030
sp|Q5MPP0|FA2H_MOUSE Fatty acid 2-hydroxylase OS=Mus musculus GN... 131 1e-029
>sp|Q03529|SCS7_YEAST Ceramide very long chain fatty acid hydroxylase SCS7
OS=Saccharomyces cerevisiae GN=SCS7 PE=1 SV=1
Length = 384
Score = 181 bits (458), Expect = 9e-045
Identities = 99/235 (42%), Positives = 130/235 (55%), Gaps = 8/235 (3%)
Frame = -3
Query: 930 VDLDKPLVFQV---GHLGEEYQEWIHQPIVCVEGPRFFQSDFWEFLTRTVWWTIPTIWLP 760
+DL++PL+ Q+ + Y + IH+P +G +F E LT+T WW +P WLP
Sbjct: 148 LDLNRPLLMQILRSDFKKDFYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLP 207
Query: 759 VVCYVLSISAARGLTFPQMGLIVAFGVFTWTLLEYTLHRFLFHIE---TKSYWANTAHYL 589
VV Y + + A + + + GVF WTL+EY LHRFLFH + +S A H+L
Sbjct: 208 VVVYHMGV-ALKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFL 266
Query: 588 LHGCHHKHPQDGLRHVFPPTATAILLVPLWKLLHLIATPATAPAMLGGILFGYVMYDCTH 409
LHGCHH P D R V PPT IL P +KL+ + A A G LFGYV YD H
Sbjct: 267 LHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFGYVCYDECH 326
Query: 408 FYLHHGQPKEPTFKHLKKYHLNHHFRIQDKGYGITSSLWDRVFGTLPGIKAAQKK 244
F+LHH + P + LKKYHL HH++ G+G+TS WD VFGT G A K
Sbjct: 327 FFLHHSK-LPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVFGTYLGPDAPLSK 380
>sp|O13846|SCS7_SCHPO Ceramide very long chain fatty acid hydroxylase-like
protein C19G12.08 OS=Schizosaccharomyces pombe GN=SPAC19G12.08 PE=2
SV=1
Length = 347
Score = 161 bits (407), Expect = 7e-039
Identities = 89/228 (39%), Positives = 123/228 (53%), Gaps = 12/228 (5%)
Frame = -3
Query: 930 VDLDKPLVFQV--GHLGEE-YQEWIHQP-IVCVEGPRFFQSDFWEFLTRTVWWTIPTIWL 763
+DL KPL+ Q+ G++ ++ Y + +H+P G +F E LT+T W+ IP IW+
Sbjct: 107 LDLKKPLLPQILFGNIKKDVYLDQVHRPRHYRGSGSAPLFGNFLEPLTKTPWYMIPLIWV 166
Query: 762 PVVCYVLSISAARGLTFPQMGLIVAFGVFTWTLLEYTLHRFLFHIETKSYWAN-----TA 598
P V Y + A G+ F G+FTWTL+EYT+HRFLFH++ Y + T
Sbjct: 167 PCVTYGF-LYACTGIPFSVAITFFIIGLFTWTLVEYTMHRFLFHLD--EYTPDHPIFLTM 223
Query: 597 HYLLHGCHHKHPQDGLRHVFPPTATAILLVPLWKLLHLIATPATAPAMLGGILFGYVMYD 418
H+ HGCHH P D R V PP I P + + L+ A G + GYV YD
Sbjct: 224 HFAFHGCHHFLPADKYRLVMPPALFLIFATPWYHFIQLVLPHYIGVAGFSGAILGYVFYD 283
Query: 417 CTHFYLHHGQPKEPTFKHLKKYHLNHHFRIQDKGYGITSSLWDRVFGT 274
TH++LHH + LK +HL+HH++ YGITS WDRVFGT
Sbjct: 284 LTHYFLHHRRMPNAYLTDLKTWHLDHHYKDYKSAYGITSWFWDRVFGT 331
>sp|Q2LAM0|FA2H_RAT Fatty acid 2-hydroxylase OS=Rattus norvegicus GN=Fa2h PE=1
SV=2
Length = 372
Score = 136 bits (341), Expect = 3e-031
Identities = 64/148 (43%), Positives = 94/148 (63%), Gaps = 4/148 (2%)
Frame = -3
Query: 705 MGLIVAFGVFTWTLLEYTLHRFLFHIE--TKSYWANTAHYLLHGCHHKHPQDGLRHVFPP 532
+GL V G+ WTL+EY +HRFLFH++ + S++ H+++HG HHK P DG R VFPP
Sbjct: 216 IGLFV-LGMLIWTLVEYLIHRFLFHMKPPSNSHYLIMLHFVMHGQHHKAPFDGSRLVFPP 274
Query: 531 TATAILLVPLWKLLHLIATPATAPAMLGGILFGYVMYDCTHFYLHHGQPKEPTFKH-LKK 355
++++ + L LI A A + G L GYV+YD TH+YLH G P + ++ + +K
Sbjct: 275 VPASVVVAFFYVFLRLILPEAVAGILFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYNMKA 334
Query: 354 YHLNHHFRIQDKGYGITSSLWDRVFGTL 271
+H+ HHF Q G+GI++ LWD F TL
Sbjct: 335 HHVKHHFEYQKSGFGISTKLWDYFFHTL 362
Score = 80 bits (197), Expect = 2e-014
Identities = 40/82 (48%), Positives = 54/82 (65%), Gaps = 3/82 (3%)
Frame = -3
Query: 930 VDLDKPLVFQVGHLGEEYQEWIHQPIVCVEGPRFFQSDFWEFLTRTVWWTIPTIWLPVVC 751
VD KPL++QVGHLGE+Y EW+HQP+ R F SD E ++TVW+++P IW+P+V
Sbjct: 124 VDWQKPLLWQVGHLGEKYDEWVHQPV--ARPIRLFHSDLIEAFSKTVWYSVPIIWVPLVL 181
Query: 750 YVLSISAARGLTFPQMGLIVAF 685
Y LS S R LT + L +F
Sbjct: 182 Y-LSWSYYRTLTQDNIRLFASF 202
>sp|Q4R4P4|FA2H_MACFA Fatty acid 2-hydroxylase OS=Macaca fascicularis GN=FA2H
PE=2 SV=1
Length = 372
Score = 135 bits (339), Expect = 6e-031
Identities = 62/141 (43%), Positives = 89/141 (63%), Gaps = 3/141 (2%)
Frame = -3
Query: 684 GVFTWTLLEYTLHRFLFHIE--TKSYWANTAHYLLHGCHHKHPQDGLRHVFPPTATAILL 511
G+F W+L+EY +HRFLFH++ + SY+ H+++HG HHK P DG R VFPP ++++
Sbjct: 222 GIFLWSLIEYLIHRFLFHMKPPSDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVI 281
Query: 510 VPLWKLLHLIATPATAPAMLGGILFGYVMYDCTHFYLHHGQPKEPTFKH-LKKYHLNHHF 334
+ L LI A + G L GYV+YD TH+YLH G P ++ + LK +H+ HHF
Sbjct: 282 GVFYLCLQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHRGSYLYNLKAHHVKHHF 341
Query: 333 RIQDKGYGITSSLWDRVFGTL 271
Q G+GI++ LWD F TL
Sbjct: 342 AHQKSGFGISTKLWDYCFHTL 362
Score = 79 bits (192), Expect = 6e-014
Identities = 44/86 (51%), Positives = 57/86 (66%), Gaps = 6/86 (6%)
Frame = -3
Query: 930 VDLDKPLVFQVGHLGEEYQEWIHQPIVCVEGPRFFQSDFWEFLTRTVWWTIPTIWLPVVC 751
VD KPL++QVGHLGE+Y EW+HQP+ R F SD E L++TVW+++P IW+P+V
Sbjct: 124 VDWQKPLLWQVGHLGEKYDEWVHQPV--TRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVL 181
Query: 750 YVLSISAARGLTFPQMGLIVAFGVFT 673
Y LS S R TF Q G + F FT
Sbjct: 182 Y-LSWSYYR--TFAQ-GNVRLFTSFT 203
>sp|Q7L5A8|FA2H_HUMAN Fatty acid 2-hydroxylase OS=Homo sapiens GN=FA2H PE=1
SV=1
Length = 372
Score = 134 bits (335), Expect = 2e-030
Identities = 61/141 (43%), Positives = 89/141 (63%), Gaps = 3/141 (2%)
Frame = -3
Query: 684 GVFTWTLLEYTLHRFLFHIE--TKSYWANTAHYLLHGCHHKHPQDGLRHVFPPTATAILL 511
G F W+L+EY +HRFLFH++ + SY+ H+++HG HHK P DG R VFPP ++++
Sbjct: 222 GTFLWSLIEYLIHRFLFHMKPPSDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVI 281
Query: 510 VPLWKLLHLIATPATAPAMLGGILFGYVMYDCTHFYLHHGQPKEPTFKH-LKKYHLNHHF 334
+ + LI A + G L GYV+YD TH+YLH G P + ++ + LK +H+ HHF
Sbjct: 282 GVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHF 341
Query: 333 RIQDKGYGITSSLWDRVFGTL 271
Q G+GI++ LWD F TL
Sbjct: 342 AHQKSGFGISTKLWDYCFHTL 362
Score = 80 bits (196), Expect = 2e-014
Identities = 49/127 (38%), Positives = 70/127 (55%), Gaps = 7/127 (5%)
Frame = -3
Query: 930 VDLDKPLVFQVGHLGEEYQEWIHQPIVCVEGPRFFQSDFWEFLTRTVWWTIPTIWLPVVC 751
VD KPL++QVGHLGE+Y EW+HQP+ R F SD E L++TVW+++P IW+P+V
Sbjct: 124 VDWRKPLLWQVGHLGEKYDEWVHQPV--TRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVL 181
Query: 750 YVLSISAARGLTFPQMGLIVAFGVFTWTLLEYTLHRFLFHIETKSYWANTAHYLLHG--C 577
Y LS S R + L +F + ++ LF + T + + YL+H
Sbjct: 182 Y-LSWSYYRTFAQGNVRLFTSFTTEYTVAVPKSMFPGLFMLGT--FLWSLIEYLIHRFLF 238
Query: 576 HHKHPQD 556
H K P D
Sbjct: 239 HMKPPSD 245
>sp|Q5MPP0|FA2H_MOUSE Fatty acid 2-hydroxylase OS=Mus musculus GN=Fa2h PE=1
SV=1
Length = 372
Score = 131 bits (328), Expect = 1e-029
Identities = 61/148 (41%), Positives = 91/148 (61%), Gaps = 4/148 (2%)
Frame = -3
Query: 705 MGLIVAFGVFTWTLLEYTLHRFLFHIE--TKSYWANTAHYLLHGCHHKHPQDGLRHVFPP 532
+GL V G+ WT +EY +HRFLFH++ + S++ H+++HG HHK P DG R VFPP
Sbjct: 216 IGLFV-LGMLFWTFVEYVIHRFLFHMKPPSNSHYLIMLHFVMHGQHHKAPFDGSRLVFPP 274
Query: 531 TATAILLVPLWKLLHLIATPATAPAMLGGILFGYVMYDCTHFYLHHGQPKEPTFKH-LKK 355
++++ + L LI + G L GYV+YD TH+YLH G P + ++ + +K
Sbjct: 275 VPASLVIAFFYVFLRLILPETVGGIIFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYNMKA 334
Query: 354 YHLNHHFRIQDKGYGITSSLWDRVFGTL 271
+H+ HHF Q G+GI++ LWD F TL
Sbjct: 335 HHVKHHFEYQKSGFGISTKLWDYFFHTL 362
Score = 78 bits (191), Expect = 8e-014
Identities = 38/72 (52%), Positives = 50/72 (69%), Gaps = 3/72 (4%)
Frame = -3
Query: 930 VDLDKPLVFQVGHLGEEYQEWIHQPIVCVEGPRFFQSDFWEFLTRTVWWTIPTIWLPVVC 751
VD KPL++QVGHLGE+Y EW+HQP+ R F SD E ++TVW+++P IW+P+V
Sbjct: 124 VDWQKPLLWQVGHLGEKYDEWVHQPV--ARPIRLFHSDLIEAFSKTVWYSVPIIWVPLVL 181
Query: 750 YVLSISAARGLT 715
Y LS S R LT
Sbjct: 182 Y-LSWSYYRTLT 192
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,471,325,924
Number of Sequences: 518415
Number of Extensions: 72471325924
Number of Successful Extensions: 505334272
Number of sequences better than 0.0: 0
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