BLASTX 7.6.2
Query= UN17664 /QuerySize=1535
(1534 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q0WQF7|OPD21_ARATH Dihydrolipoyllysine-residue acetyltransfer... 509 3e-143
sp|Q1RJT3|ODP2_RICBR Dihydrolipoyllysine-residue acetyltransfera... 213 3e-054
sp|Q8BMF4|ODP2_MOUSE Dihydrolipoyllysine-residue acetyltransfera... 206 4e-052
sp|Q4ULG1|ODP2_RICFE Dihydrolipoyllysine-residue acetyltransfera... 205 7e-052
sp|Q86AD5|Y1564_DICDI Pyruvate dehydrogenase complex subunit hom... 204 2e-051
sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltransfera... 203 4e-051
sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransferase... 203 5e-051
sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltransfera... 202 8e-051
sp|P22439|ODPX_BOVIN Pyruvate dehydrogenase protein X component ... 202 8e-051
sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransfera... 201 1e-050
sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltransfera... 201 1e-050
sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X component,... 200 2e-050
sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X component,... 198 2e-049
sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltransfera... 197 2e-049
sp|P12695|ODP2_YEAST Dihydrolipoyllysine-residue acetyltransfera... 196 3e-049
sp|Q68WK6|ODP2_RICTY Dihydrolipoyllysine-residue acetyltransfera... 193 4e-048
sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltransfera... 193 4e-048
sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltransfera... 185 8e-046
sp|P21883|ODP2_BACSU Dihydrolipoyllysine-residue acetyltransfera... 142 1e-032
>sp|Q0WQF7|OPD21_ARATH Dihydrolipoyllysine-residue acetyltransferase component 1
of pyruvate dehydrogenase complex, mitochondrial OS=Arabidopsis
thaliana GN=LTA3 PE=1 SV=2
Length = 637
Score = 509 bits (1309), Expect = 3e-143
Identities = 268/298 (89%), Positives = 279/298 (93%), Gaps = 5/298 (1%)
Frame = +3
Query: 345 MEASSIEASGPYGTLLKSDVVAAIASGKTSKKSLSTEKKQPSKENLSKSSSVSRPESKSS 524
+EASSIEASGPYGTLLKSDVVAAIASGK SK S ST+KKQPSKE SKSSS S+P S
Sbjct: 344 LEASSIEASGPYGTLLKSDVVAAIASGKASKSSASTKKKQPSKETPSKSSSTSKP----S 399
Query: 525 VTPS-NDYEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVVLDPLLAFRKELQENHGVKV 701
VT S N+YEDFPNSQIRKIIAKRLLESKQKIPHLYL SDVVLDPLLAFRKELQENHGVKV
Sbjct: 400 VTQSDNNYEDFPNSQIRKIIAKRLLESKQKIPHLYLQSDVVLDPLLAFRKELQENHGVKV 459
Query: 702 SVNDIVIKAVAVALRNVRHANAFWDAEKGEIVLCEDVDISIAVATEKGLMTPIIRNADQK 881
SVNDIVIKAVAVALRNVR ANAFWDAEKG+IV+C+ VDISIAVATEKGLMTPII+NADQK
Sbjct: 460 SVNDIVIKAVAVALRNVRQANAFWDAEKGDIVMCDSVDISIAVATEKGLMTPIIKNADQK 519
Query: 882 SISAISSEVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVDQFCAIINPPQAGILAVGR 1061
SISAIS EVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVD FCAIINPPQAGILAVGR
Sbjct: 520 SISAISLEVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVDNFCAIINPPQAGILAVGR 579
Query: 1062 GNKVVEAVLGIDGTEKPSVVTKMNVTLSADHRIFDGQVGASFLSELRSNFEDVRRLLL 1235
GNKVVE V+G+DG EKPSVVTKMNVTLSADHRIFDGQVGASF+SELRSNFEDVRRLLL
Sbjct: 580 GNKVVEPVIGLDGIEKPSVVTKMNVTLSADHRIFDGQVGASFMSELRSNFEDVRRLLL 637
Score = 200 bits (506), Expect = 4e-050
Identities = 104/116 (89%), Positives = 105/116 (90%)
Frame = +2
Query: 2 NIAKWWKKEGDKIEVGDVIGEIETDKATLEFESLEEGYLAKILIPEGSKDVAVGKPIALI 181
NIAKWWKKEGDKIEVGDVIGEIETDKATLEFESLEEGYLAKILIPEGSKDVAVGKPIALI
Sbjct: 228 NIAKWWKKEGDKIEVGDVIGEIETDKATLEFESLEEGYLAKILIPEGSKDVAVGKPIALI 287
Query: 182 VEDAESIETIKSSSAGGSEAVTEKLAPQSVVDKSGGKKAGFTKISPAAKLLILEHG 349
VEDAESIE IKSSSAG SE T K P SVVDK +KAGFTKISPAAKLLILEHG
Sbjct: 288 VEDAESIEAIKSSSAGSSEVDTVKEVPDSVVDKPTERKAGFTKISPAAKLLILEHG 343
>sp|Q1RJT3|ODP2_RICBR Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia bellii (strain RML369-C)
GN=pdhC PE=3 SV=1
Length = 418
Score = 213 bits (542), Expect = 3e-054
Identities = 122/235 (51%), Positives = 157/235 (66%), Gaps = 11/235 (4%)
Frame = +3
Query: 540 DYEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVVLDPLLAFRKELQENHG----VKVSV 707
+Y PN+ IRKIIAKRLLESKQ +PH YLS + +D LL R+++ ++ G K+SV
Sbjct: 187 EYRLAPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIREDINKSFGDDKSAKISV 246
Query: 708 NDIVIKAVAVALRNVRHANAFWDAEKGEIVLCEDVDISIAVATEKGLMTPIIRNADQKSI 887
ND +I AVA AL+ V +ANA W + I +VDIS+AVA E GL+TPIIRNADQK+I
Sbjct: 247 NDFIILAVAKALQEVPNANASWGDD--AIRYYNNVDISVAVAIENGLVTPIIRNADQKNI 304
Query: 888 SAISSEVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVDQFCAIINPPQAGILAVGRGN 1067
+SSE+K L +KAR KL P EFQGG F+ISNLGMY + F AIINPPQ+ I+ VG +
Sbjct: 305 VDLSSEMKGLIKKARENKLTPEEFQGGGFTISNLGMYGIKNFNAIINPPQSCIMGVGSSS 364
Query: 1068 KVVEAVLGIDGTEKPSVVTKMNVTLSADHRIFDGQVGASFLSELRSNFEDVRRLL 1232
K I ++ S+ T M+VTLSADHR+ DG VGA FL+ + E +L
Sbjct: 365 K-----RAIVKNDQISIATIMDVTLSADHRVVDGAVGAEFLAAFKRFIESPALML 414
>sp|Q8BMF4|ODP2_MOUSE Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Mus musculus GN=Dlat
PE=1 SV=2
Length = 642
Score = 206 bits (523), Expect = 4e-052
Identities = 121/269 (44%), Positives = 171/269 (63%), Gaps = 15/269 (5%)
Frame = +3
Query: 423 GKTSKKSLSTEKKQPSKENLSKSSSVSRPESKSSVTPSNDYEDFPNSQIRKIIAKRLLES 602
G+ KK + + PSK + +++++ P + + P+ + D P S IR++IA+RL++S
Sbjct: 377 GRIIKKDI--DSFVPSKAAPAAAAAMAPPGPRVAPAPAGVFTDIPISNIRRVIAQRLMQS 434
Query: 603 KQKIPHLYLSSDVVLDPLLAFRKELQ---ENHGVKVSVNDIVIKAVAVALRNVRHANAFW 773
KQ IPH YLS DV + +L RKEL E G K+SVND +IKA A+A V AN+ W
Sbjct: 435 KQTIPHYYLSVDVNMGEVLLVRKELNKMLEGKG-KISVNDFIIKASALACLKVPEANSSW 493
Query: 774 DAEKGEIVLCED--VDISIAVATEKGLMTPIIRNADQKSISAISSEVKELAQKARSGKLA 947
+ V+ ++ VD+S+AV+T GL+TPI+ NA K + I+S+V LA KAR GKL
Sbjct: 494 ----MDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGLETIASDVVSLASKAREGKLQ 549
Query: 948 PHEFQGGTFSISNLGMYPVDQFCAIINPPQAGILAVGRGNKVVEAVLGIDGTEKPSVVTK 1127
PHEFQGGTF+ISNLGM+ + F AIINPPQA ILA+G + ++ D + V +
Sbjct: 550 PHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASE---DKLIPADNEKGFDVASV 606
Query: 1128 MNVTLSADHRIFDGQVGASFLSELRSNFE 1214
M+VTLS DHR+ DG VGA +L+E + E
Sbjct: 607 MSVTLSCDHRVVDGAVGAQWLAEFKKYLE 635
>sp|Q4ULG1|ODP2_RICFE Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia felis GN=pdhC PE=3 SV=1
Length = 412
Score = 205 bits (521), Expect = 7e-052
Identities = 115/229 (50%), Positives = 151/229 (65%), Gaps = 11/229 (4%)
Frame = +3
Query: 540 DYEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVVLDPLLAFR----KELQENHGVKVSV 707
+Y PN+ IRKIIAKRLLESKQ +PH YLS + +D LL R K E+ ++SV
Sbjct: 184 EYRLVPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIREDINKSFSEDKSTRISV 243
Query: 708 NDIVIKAVAVALRNVRHANAFWDAEKGEIVLCEDVDISIAVATEKGLMTPIIRNADQKSI 887
ND +I AVA AL+ + +ANA W + I +VDIS+AVA E GL+TPI++NA+QK+I
Sbjct: 244 NDFIILAVAKALQELPNANASWGED--AIRYHNNVDISVAVAIENGLVTPIVKNANQKNI 301
Query: 888 SAISSEVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVDQFCAIINPPQAGILAVGRGN 1067
+S E+KEL +KA+ KL P EFQGG F+ISNLGMY + F AIINPPQ+ I+ VG
Sbjct: 302 IELSREMKELIKKAKDNKLTPEEFQGGGFTISNLGMYGIKNFNAIINPPQSCIMGVG--- 358
Query: 1068 KVVEAVLGIDGTEKPSVVTKMNVTLSADHRIFDGQVGASFLSELRSNFE 1214
A I ++ ++ T M+VTLSADHR+ DG VGA FL+ + E
Sbjct: 359 --ASAKRAIVKNDQVTIATIMDVTLSADHRVVDGAVGAEFLAAFKKFIE 405
>sp|Q86AD5|Y1564_DICDI Pyruvate dehydrogenase complex subunit homolog
DDB_G0271564, mitochondrial OS=Dictyostelium discoideum GN=pdhX PE=3
SV=1
Length = 413
Score = 204 bits (518), Expect = 2e-051
Identities = 119/275 (43%), Positives = 172/275 (62%), Gaps = 23/275 (8%)
Frame = +3
Query: 402 VVAAIASGKTSKKSLSTEKKQPS-----KENLSKSSSVSRPESKSSVTPSNDYEDFPNSQ 566
+ +++ S + S S + P+ K+ + ++++ ++KS V YED PN+
Sbjct: 81 IASSVKSSQPSSSSSPSIVDSPTLTSQIKDQIKIVTTITNDKNKSKVI----YEDIPNNN 136
Query: 567 IRKIIAKRLLESKQKIPHLYLSSDVVLDPLLAFRKELQENHGVKVSVNDIVIKAVAVALR 746
IR++IA +L +SKQ++PH Y++ + LD +LA RK + EN VK+SVND V++A A+ALR
Sbjct: 137 IRRVIATKLSQSKQQVPHFYMTVECELDNVLAMRKSMPEN--VKISVNDFVLRACALALR 194
Query: 747 NVRHANAFWDAEKGEIVLCEDVDISIAVATEKGLMTPIIRNADQKSISAISSEVKELAQK 926
+ AN+ W E GE +L VDIS AV+T++GL+TPII N D+K + AIS+E K+LA K
Sbjct: 195 DNPQANSKWSDEHGEAILNPTVDISFAVSTDRGLITPIITNTDKKQLLAISNESKQLALK 254
Query: 927 ARSGKLAPHEFQGGTFSISNLGMYPVDQFCAIINPPQAGILAVGRGNKV---------VE 1079
AR GKL P EF GGTFS+SNLGM+ + F AIIN PQAGILA+G G KV +E
Sbjct: 255 ARDGKLKPEEFIGGTFSVSNLGMFGITSFNAIINYPQAGILAIGTGRKVLRPPSTYQPIE 314
Query: 1080 AVLGID-GTEKPSVVTKMNVTLSAD--HRIFDGQV 1175
L G+E S + N L+ + ++FD V
Sbjct: 315 TNLNASYGSEGKSEIINTNGPLTTEQLEKLFDNTV 349
>sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia conorii GN=pdhC PE=3 SV=1
Length = 412
Score = 203 bits (515), Expect = 4e-051
Identities = 114/229 (49%), Positives = 151/229 (65%), Gaps = 11/229 (4%)
Frame = +3
Query: 540 DYEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVVLDPLLAFRKEL----QENHGVKVSV 707
+Y PN+ IRKIIAKRLLESKQ +PH YLS + +D LL R+++ E+ ++SV
Sbjct: 184 EYRLVPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLLDIREDINKFFSEDKSTRISV 243
Query: 708 NDIVIKAVAVALRNVRHANAFWDAEKGEIVLCEDVDISIAVATEKGLMTPIIRNADQKSI 887
ND +I AVA AL+ V +ANA W + I +VDIS+AVA E GL+TPI++NA+QK+I
Sbjct: 244 NDFIILAVAKALQEVPNANASWGED--AIRYYNNVDISVAVAIENGLVTPIVKNANQKNI 301
Query: 888 SAISSEVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVDQFCAIINPPQAGILAVGRGN 1067
+S E+K L +KA+ KL P EFQGG F+ISNLGMY + F AIINPPQ+ I+ VG
Sbjct: 302 LELSREMKALIKKAKDNKLTPEEFQGGGFTISNLGMYGIKNFNAIINPPQSCIMGVG--- 358
Query: 1068 KVVEAVLGIDGTEKPSVVTKMNVTLSADHRIFDGQVGASFLSELRSNFE 1214
A I ++ ++ T M+VTLSADHR+ DG VGA FL + E
Sbjct: 359 --ASAKRAIVKNDQITIATIMDVTLSADHRVVDGAVGAEFLVAFKKFIE 405
>sp|P08461|ODP2_RAT Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Rattus norvegicus
GN=Dlat PE=1 SV=3
Length = 632
Score = 203 bits (514), Expect = 5e-051
Identities = 116/247 (46%), Positives = 161/247 (65%), Gaps = 13/247 (5%)
Frame = +3
Query: 489 SSSVSRPESKSSVTPSNDYEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVVLDPLLAFR 668
+++ + P + + TP+ + D P S IR++IA+RL++SKQ IPH YLS DV + +L R
Sbjct: 387 AAAAAPPGPRVAPTPAGVFIDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGEVLLVR 446
Query: 669 KELQ---ENHGVKVSVNDIVIKAVAVALRNVRHANAFWDAEKGEIVLCED--VDISIAVA 833
KEL E G K+SVND +IKA A+A V AN+ W + V+ ++ VD+S+AV+
Sbjct: 447 KELNKMLEGKG-KISVNDFIIKASALACLKVPEANSSW----MDTVIRQNHVVDVSVAVS 501
Query: 834 TEKGLMTPIIRNADQKSISAISSEVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVDQF 1013
T GL+TPI+ NA K + I+S+V LA KAR GKL PHEFQGGTF+ISNLGM+ + F
Sbjct: 502 TPAGLITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIKNF 561
Query: 1014 CAIINPPQAGILAVGRGNKVVEAVLGIDGTEKPSVVTKMNVTLSADHRIFDGQVGASFLS 1193
AIINPPQA ILA+G + ++ D + V + M+VTLS DHR+ DG VGA +L+
Sbjct: 562 SAIINPPQACILAIGASE---DKLIPADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLA 618
Query: 1194 ELRSNFE 1214
E + E
Sbjct: 619 EFKKYLE 625
>sp|P36413|ODP2_DICDI Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Dictyostelium
discoideum GN=pdhC PE=1 SV=2
Length = 635
Score = 202 bits (512), Expect = 8e-051
Identities = 111/259 (42%), Positives = 160/259 (61%), Gaps = 7/259 (2%)
Frame = +3
Query: 465 PSKENLS---KSSSVSRPESKSSVTPSNDYEDFPNSQIRKIIAKRLLESKQKIPHLYLSS 635
P K+ ++ + + + + ++ T S ++ D P+S IRK+ A RL ESKQ IPH YL+
Sbjct: 380 PQKQEVAQQQQQQTTTTTKKPTTPTSSGEFTDIPHSNIRKVTAARLTESKQTIPHYYLTM 439
Query: 636 DVVLDPLLAFRKELQENHGVKVSVNDIVIKAVAVALRNVRHANAFWDAEKGEIVLCEDVD 815
+ +D LL R EL + VK+SVND ++KA A ALR+ N+ W + I ++D
Sbjct: 440 ECRVDKLLKLRSELNAMNTVKISVNDFIVKASAAALRDNPVVNSTWTDQ--FIRRYHNID 497
Query: 816 ISIAVATEKGLMTPIIRNADQKSISAISSEVKELAQKARSGKLAPHEFQGGTFSISNLGM 995
I++AV T +GL TPI+R D K +++IS+ VK+LA+KA++GKL P EF+ GTF+ISNLGM
Sbjct: 498 INVAVNTPQGLFTPIVRGVDMKGLNSISTSVKQLAEKAQNGKLHPSEFESGTFTISNLGM 557
Query: 996 YPVDQFCAIINPPQAGILAVGRGNKVVEAVLGIDGTEKPSVVTKMNVTLSADHRIFDGQV 1175
+ QF A+INPPQA ILAV G VL T ++VTLS DHR+ DG V
Sbjct: 558 LGIKQFAAVINPPQAAILAV--GTTETRVVLSNKPDSPYETATILSVTLSCDHRVIDGAV 615
Query: 1176 GASFLSELRSNFEDVRRLL 1232
GA +L + E+ +L+
Sbjct: 616 GAEWLKSFKDYVENPIKLI 634
>sp|P22439|ODPX_BOVIN Pyruvate dehydrogenase protein X component OS=Bos taurus
GN=PDHX PE=1 SV=3
Length = 501
Score = 202 bits (512), Expect = 8e-051
Identities = 112/268 (41%), Positives = 163/268 (60%), Gaps = 8/268 (2%)
Frame = +3
Query: 441 SLSTEKKQPSKENLSKSSSVSRPESKSSVTP-----SNDYEDFPNSQIRKIIAKRLLESK 605
+L T P + ++S RP TP + + P S IR++IAKRL ESK
Sbjct: 236 ALPTTPAAPLPPQAAATASYPRPMIPPVSTPGQPNVEGTFTEIPASNIRRVIAKRLTESK 295
Query: 606 QKIPHLYLSSDVVLDPLLAFRKELQENHGVKVSVNDIVIKAVAVALRNVRHANAFWDAEK 785
IPH Y ++D L +L R+ L + +KVSVND +IKA AV L+ + + NA WD E
Sbjct: 296 STIPHAYATTDCDLGAVLTARQNLVRD-DIKVSVNDFIIKAAAVTLKQMPNVNASWDGEG 354
Query: 786 GEIVLCEDVDISIAVATEKGLMTPIIRNADQKSISAISSEVKELAQKARSGKLAPHEFQG 965
+ + +DIS+AVAT++GL+TP+I++A K + I+ VK L++KAR GKL P E+QG
Sbjct: 355 AKQL--PSIDISVAVATDRGLITPVIKDAAAKGLQEIADSVKALSKKARDGKLLPEEYQG 412
Query: 966 GTFSISNLGMYPVDQFCAIINPPQAGILAVGRGNKVVEAVLGIDGTEKPSVVTKMNVTLS 1145
G+FSISNLGM+ +D+F A+INPPQA ILAVGR V++ +G + + VT+S
Sbjct: 413 GSFSISNLGMFGIDEFTAVINPPQACILAVGRFRPVLKLTQDEEGNAQLQQRQLITVTMS 472
Query: 1146 ADHRIFDGQVGASFLSELRSNFEDVRRL 1229
+D R+ D ++ FL ++N E+ RL
Sbjct: 473 SDSRVVDDELATRFLESFKANLENPLRL 500
>sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens GN=DLAT
PE=1 SV=3
Length = 647
Score = 201 bits (511), Expect = 1e-050
Identities = 122/269 (45%), Positives = 169/269 (62%), Gaps = 15/269 (5%)
Frame = +3
Query: 423 GKTSKKSLSTEKKQPSKENLSKSSSVSRPESKSSVTPSNDYEDFPNSQIRKIIAKRLLES 602
G+ +KK + + PSK + ++ V + P+ + D P S IR++IA+RL++S
Sbjct: 382 GRITKKDI--DSFVPSKVAPAPAAVVPPTGPGMAPVPTGVFTDIPISNIRRVIAQRLMQS 439
Query: 603 KQKIPHLYLSSDVVLDPLLAFRKELQE--NHGVKVSVNDIVIKAVAVALRNVRHANAFWD 776
KQ IPH YLS DV + +L RKEL + K+SVND +IKA A+A V AN+ W
Sbjct: 440 KQTIPHYYLSIDVNMGEVLLVRKELNKILEGRSKISVNDFIIKASALACLKVPEANSSW- 498
Query: 777 AEKGEIVLCED--VDISIAVATEKGLMTPIIRNADQKSISAISSEVKELAQKARSGKLAP 950
+ V+ ++ VD+S+AV+T GL+TPI+ NA K + I+++V LA KAR GKL P
Sbjct: 499 ---MDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGVETIANDVVSLATKAREGKLQP 555
Query: 951 HEFQGGTFSISNLGMYPVDQFCAIINPPQAGILAVGRG-NKVVEAVLGIDGTEKPSVVTK 1127
HEFQGGTF+ISNLGM+ + F AIINPPQA ILA+G +K+V A D + V +
Sbjct: 556 HEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLVPA----DNEKGFDVASM 611
Query: 1128 MNVTLSADHRIFDGQVGASFLSELRSNFE 1214
M+VTLS DHR+ DG VGA +L+E R E
Sbjct: 612 MSVTLSCDHRVVDGAVGAQWLAEFRKYLE 640
>sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Zymomonas mobilis GN=pdhC PE=3 SV=2
Length = 440
Score = 201 bits (511), Expect = 1e-050
Identities = 107/243 (44%), Positives = 157/243 (64%), Gaps = 10/243 (4%)
Frame = +3
Query: 483 SKSSSVSRPESKSSVTPSNDYEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVVLDPLLA 662
S + SVS PE+ +T + S +R++IA+RL ESKQ IPH+YL+ DV +D LL
Sbjct: 193 SSNPSVSTPEASGKITHDTPHNSIKLSNMRRVIARRLTESKQNIPHIYLTVDVQMDALLK 252
Query: 663 FRKELQEN---HGVKVSVNDIVIKAVAVALRNVRHANAFWDAEKGEIVLCEDVDISIAVA 833
R EL E+ +K+SVND++IKA A+AL+ + N +D + +++ DIS+AV+
Sbjct: 253 LRSELNESLAVQNIKISVNDMLIKAQALALKATPNVNVAFDGD--QMLQFSQADISVAVS 310
Query: 834 TEKGLMTPIIRNADQKSISAISSEVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVDQF 1013
E GL+TPI++ AD KS+SA+S E+KEL +AR G+L P E+QGGT SISN+GM+ + QF
Sbjct: 311 VEGGLITPILKQADTKSLSALSVEMKELIARAREGRLQPQEYQGGTSSISNMGMFGIKQF 370
Query: 1014 CAIINPPQAGILAVGRGNKVVEAVLGIDGTEKPSVVTKMNVTLSADHRIFDGQVGASFLS 1193
A+INPPQA ILA+G G + + + ++ T +T S DHR+ DG A+F+S
Sbjct: 371 NAVINPPQASILAIGSGERRPWVI-----DDAITIATVATITGSFDHRVIDGADAAAFMS 425
Query: 1194 ELR 1202
+
Sbjct: 426 AFK 428
>sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial
OS=Homo sapiens GN=PDHX PE=1 SV=3
Length = 501
Score = 200 bits (508), Expect = 2e-050
Identities = 113/260 (43%), Positives = 159/260 (61%), Gaps = 8/260 (3%)
Frame = +3
Query: 465 PSKENLSKSSSVSRPESKSSVTPS-----NDYEDFPNSQIRKIIAKRLLESKQKIPHLYL 629
PS + S RP TP + + P S IR++IAKRL ESK +PH Y
Sbjct: 244 PSPLQATAGPSYPRPVIPPVSTPGQPNAVGTFTEIPASNIRRVIAKRLTESKSTVPHAYA 303
Query: 630 SSDVVLDPLLAFRKELQENHGVKVSVNDIVIKAVAVALRNVRHANAFWDAEKGEIVLCED 809
++D L +L R++L ++ +KVSVND +IKA AV L+ + N WD E + +
Sbjct: 304 TADCDLGAVLKVRQDLVKD-DIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQL--PF 360
Query: 810 VDISIAVATEKGLMTPIIRNADQKSISAISSEVKELAQKARSGKLAPHEFQGGTFSISNL 989
+DIS+AVAT+KGL+TPII++A K I I+ VK L++KAR GKL P E+QGG+FSISNL
Sbjct: 361 IDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNL 420
Query: 990 GMYPVDQFCAIINPPQAGILAVGRGNKVVEAVLGIDGTEKPSVVTKMNVTLSADHRIFDG 1169
GM+ +D+F A+INPPQA ILAVGR V++ +G K + VT+S+D R+ D
Sbjct: 421 GMFGIDEFTAVINPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDD 480
Query: 1170 QVGASFLSELRSNFEDVRRL 1229
++ FL ++N E+ RL
Sbjct: 481 ELATRFLKSFKANLENPIRL 500
>sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X component, mitochondrial
OS=Mus musculus GN=Pdhx PE=2 SV=1
Length = 501
Score = 198 bits (501), Expect = 2e-049
Identities = 105/229 (45%), Positives = 151/229 (65%), Gaps = 3/229 (1%)
Frame = +3
Query: 543 YEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVVLDPLLAFRKELQENHGVKVSVNDIVI 722
+ + P S IR++IAKRL ESK +PH Y ++D L +L R++L ++ +KVSVND +I
Sbjct: 275 FTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRRDLVKD-DIKVSVNDFII 333
Query: 723 KAVAVALRNVRHANAFWDAEKGEIVLCEDVDISIAVATEKGLMTPIIRNADQKSISAISS 902
+A AV L+ + N WD E + + VDIS+AVAT+KGL+TPII++A K I I+
Sbjct: 334 RAAAVTLKQMPGVNVTWDGEGPKQL--PSVDISVAVATDKGLITPIIKDAAAKGIQEIAD 391
Query: 903 EVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVDQFCAIINPPQAGILAVGRGNKVVEA 1082
VK L++KAR GKL P E+QGG+FSISNLGM+ +D+F A+INPPQA ILAVGR V++
Sbjct: 392 SVKVLSKKARDGKLMPEEYQGGSFSISNLGMFGIDEFAAVINPPQACILAVGRFRPVLKL 451
Query: 1083 VLGIDGTEKPSVVTKMNVTLSADHRIFDGQVGASFLSELRSNFEDVRRL 1229
+G + + VT+S+D R+ D ++ FL ++N E+ RL
Sbjct: 452 TEDEEGNPQLQQHQLITVTMSSDSRVVDDELATRFLETFKANLENPMRL 500
>sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia prowazekii GN=pdhC PE=3
SV=1
Length = 408
Score = 197 bits (500), Expect = 2e-049
Identities = 117/250 (46%), Positives = 156/250 (62%), Gaps = 13/250 (5%)
Frame = +3
Query: 480 LSKSSSVSRPESKSSVTPSNDYEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVVLDPLL 659
LS SS S +K + +Y PN+ IRKIIAKRLLESKQ +PH YLS + +D LL
Sbjct: 162 LSYDSSTS--SNKIVYRDTEEYRSVPNNNIRKIIAKRLLESKQTVPHFYLSIECNVDKLL 219
Query: 660 AFR----KELQENHGVKVSVNDIVIKAVAVALRNVRHANAFWDAEKGEIVLCEDVDISIA 827
R K E+ K+SVND +I AVA AL+ V +ANA W + I +VDIS+A
Sbjct: 220 DVREDINKSFSEDKVTKISVNDFIILAVAKALQEVPNANASWSED--AIRYYNNVDISVA 277
Query: 828 VATEKGLMTPIIRNADQKSISAISSEVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVD 1007
VA E G++TPI+++A++K+I +S E+K L +KA+ KL P EFQGG F+ISNLGMY +
Sbjct: 278 VAIENGIVTPIVKDANKKNIIELSREMKTLIKKAKDNKLTPIEFQGGGFTISNLGMYGIK 337
Query: 1008 QFCAIINPPQAGILAVGRGNKVVEAVLGIDGTEKPSVVTKMNVTLSADHRIFDGQVGASF 1187
F AIIN PQ+ I+ VG K I ++ + T M+VTLSADHR+ DG V A F
Sbjct: 338 NFNAIINTPQSCIMGVGASTK-----RAIVKNDQIIIATIMDVTLSADHRVIDGAVSAEF 392
Query: 1188 LSELRSNFED 1217
L+ + E+
Sbjct: 393 LASFKRFIEN 402
>sp|P12695|ODP2_YEAST Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Saccharomyces
cerevisiae GN=PDA2 PE=1 SV=1
Length = 482
Score = 196 bits (498), Expect = 3e-049
Identities = 120/296 (40%), Positives = 177/296 (59%), Gaps = 11/296 (3%)
Frame = +3
Query: 360 IEASGPYGTLLKSDVVAAIASGKTSKKSLSTEKKQPSKENLSKSSSVSRPESKSSVTPSN 539
+ +GP G + K+D+ + + K+SK+S T + + SS+ + S T S
Sbjct: 194 VHGTGPRGRITKADIESYLE--KSSKQSSQTSGAAAATPAAATSSTTAGSAPSPSSTAS- 250
Query: 540 DYEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVVLDPLLAFRKELQ--ENHGVKVSVND 713
YED P S +R II +RLL+S Q IP +SS + + LL R+ L N K+S+ND
Sbjct: 251 -YEDVPISTMRSIIGERLLQSTQGIPSYIVSSKISISKLLKLRQSLNATANDKYKLSIND 309
Query: 714 IVIKAVAVALRNVRHANAFWDAEKGEIVLCEDVDISIAVATEKGLMTPIIRNADQKSISA 893
+++KA+ VA + V ANA+W + I ++VD+S+AVAT GL+TPI++N + K +S
Sbjct: 310 LLVKAITVAAKRVPDANAYWLPNENVIRKFKNVDVSVAVATPTGLLTPIVKNCEAKGLSQ 369
Query: 894 ISSEVKELAQKARSGKLAPHEFQGGTFSISNLGM-YPVDQFCAIINPPQAGILAVGRGNK 1070
IS+E+KEL ++AR KLAP EFQGGT ISN+GM V+ F +IINPPQ+ ILA+ +
Sbjct: 370 ISNEIKELVKRARINKLAPEEFQGGTICISNMGMNNAVNMFTSIINPPQSTILAIATVER 429
Query: 1071 V-VEAVLGIDGTEKPSVVTKMNVTLSADHRIFDGQVGASFLSELRSNFEDVRRLLL 1235
V VE +G + VT +T + DHR DG GA F+ EL++ E+ +LL
Sbjct: 430 VAVEDAAAENGFSFDNQVT---ITGTFDHRTIDGAKGAEFMKELKTVIENPLEMLL 482
>sp|Q68WK6|ODP2_RICTY Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rickettsia typhi GN=pdhC PE=3 SV=1
Length = 404
Score = 193 bits (489), Expect = 4e-048
Identities = 114/247 (46%), Positives = 153/247 (61%), Gaps = 11/247 (4%)
Frame = +3
Query: 486 KSSSVSRPESKSSVTPSNDYEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVVLDPLLAF 665
K +S S + + +Y PN+ IR+IIAKRLLESKQ +PH YLS + +D LL
Sbjct: 158 KQDILSYSPSTAYNRDTEEYRSVPNNNIRQIIAKRLLESKQTVPHFYLSIECNVDKLLDI 217
Query: 666 R----KELQENHGVKVSVNDIVIKAVAVALRNVRHANAFWDAEKGEIVLCEDVDISIAVA 833
R K E+ K+SVND +I AVA AL+ V +ANA W + I +VDIS+AVA
Sbjct: 218 REDINKSFSEDKLTKISVNDFIILAVAKALQEVPNANASW--AEDAIRYYNNVDISVAVA 275
Query: 834 TEKGLMTPIIRNADQKSISAISSEVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVDQF 1013
E G++TPII++A++K+I +S E+K L +KA+ KL P EFQGG F+ISNLGMY + F
Sbjct: 276 IENGIVTPIIKDANKKNIIELSHEMKILIKKAKDNKLTPVEFQGGGFTISNLGMYGIKNF 335
Query: 1014 CAIINPPQAGILAVGRGNKVVEAVLGIDGTEKPSVVTKMNVTLSADHRIFDGQVGASFLS 1193
AIIN PQ+ I+ VG K I ++ + T M+VTLSADHR+ DG V A FL+
Sbjct: 336 NAIINTPQSCIMGVGASTK-----RAIVKNDQIIIATIMDVTLSADHRVIDGAVSAEFLA 390
Query: 1194 ELRSNFE 1214
+ E
Sbjct: 391 SFKRFIE 397
>sp|O59816|ODP2_SCHPO Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex, mitochondrial OS=Schizosaccharomyces
pombe GN=SPCC794.07 PE=2 SV=1
Length = 483
Score = 193 bits (489), Expect = 4e-048
Identities = 114/254 (44%), Positives = 153/254 (60%), Gaps = 8/254 (3%)
Frame = +3
Query: 465 PSKENLSKSSSVSRPESKSSVTPSNDYEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVV 644
P N + + + + S + DYED P S +RKIIA RL ESK PH Y++ V
Sbjct: 229 PKPSNEAAAKATTPAASAADAAAPGDYEDLPLSNMRKIIASRLAESKNMNPHYYVTVSVN 288
Query: 645 LDPLLAFRKEL--QENHGVKVSVNDIVIKAVAVALRNVRHANAFWDAEKGEIVLCEDVDI 818
++ ++ R L + K+SVND+VIKA ALR V NA W + I ++VDI
Sbjct: 289 MEKIIRLRAALNAMADGRYKLSVNDLVIKATTAALRQVPEVNAAWMGD--FIRQYKNVDI 346
Query: 819 SIAVATEKGLMTPIIRNADQKSISAISSEVKELAQKARSGKLAPHEFQGGTFSISNLGMY 998
S+AVAT GL+TP+IRN ++ IS+ K+ Q+AR+ KL P E+QGGTF+ISNLGM+
Sbjct: 347 SMAVATPSGLITPVIRNTHALGLAEISTLAKDYGQRARNNKLKPEEYQGGTFTISNLGMF 406
Query: 999 PVDQFCAIINPPQAGILAVGRGNKVVEAVLGIDGTEKP-SVVTKMNVTLSADHRIFDGQV 1175
PVDQF AIINPPQA ILAVG V+ V+ +EK V M TLS+DHR+ DG +
Sbjct: 407 PVDQFTAIINPPQACILAVG---TTVDTVVPDSTSEKGFKVAPIMKCTLSSDHRVVDGAM 463
Query: 1176 GASFLSELRSNFED 1217
A F + L+ E+
Sbjct: 464 AARFTTALKKILEN 477
>sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Rhizobium meliloti GN=pdhC PE=3 SV=1
Length = 447
Score = 185 bits (469), Expect = 8e-046
Identities = 106/232 (45%), Positives = 147/232 (63%), Gaps = 14/232 (6%)
Frame = +3
Query: 543 YEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVVLDPLLAFRKELQ----ENHG---VKV 701
YE P+ +RK IAKRL+ESKQ IPH Y+S D LD L+A R +L E G K+
Sbjct: 217 YELVPHDGMRKTIAKRLVESKQTIPHFYVSVDCELDALMALRAQLNAAAPEKDGKPVYKL 276
Query: 702 SVNDIVIKAVAVALRNVRHANAFWDAEKGEIVLCEDVDISIAVATEKGLMTPIIRNADQK 881
SVND+VIKA+A+ALR+V AN W + +V + D+ +AV+ GL+TPI+R A+ K
Sbjct: 277 SVNDMVIKALALALRDVPDANVSWTDQ--NMVKHKHADVGVAVSIPGGLITPIVRQAELK 334
Query: 882 SISAISSEVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVDQFCAIINPPQAGILAVGR 1061
S+SAIS+E+K+L ++A+ KL P E+QGGT ++SN+GM V F A++NPP A ILAVG
Sbjct: 335 SLSAISNEMKDLGKRAKERKLKPEEYQGGTTAVSNMGMMGVKDFAAVVNPPHATILAVGA 394
Query: 1062 GNKVVEAVLGIDGTEKPSVVTKMNVTLSADHRIFDGQVGASFLSELRSNFED 1217
G V + ++ + M VTLS DHR DG +GA L+ + E+
Sbjct: 395 GEDRV-----VVRNKEMVIANVMTVTLSTDHRCVDGALGAELLAAFKRYIEN 441
>sp|P21883|ODP2_BACSU Dihydrolipoyllysine-residue acetyltransferase component of
pyruvate dehydrogenase complex OS=Bacillus subtilis GN=pdhC PE=1 SV=2
Length = 442
Score = 142 bits (356), Expect = 1e-032
Identities = 93/294 (31%), Positives = 156/294 (53%), Gaps = 17/294 (5%)
Frame = +3
Query: 345 MEASSIEASGPYGTLLKSDVVAAIASGKTSKKSLSTEKKQPSKENLSKSSSVSRPESKSS 524
++ + SG G ++K D+ + + G ++++ E P +E +K ++ PE +
Sbjct: 155 VDIRKVTGSGNNGRVVKEDIDSFVNGG--AQEAAPQETAAP-QETAAKPAAAPAPEGEFP 211
Query: 525 VTPSNDYEDFPNSQIRKIIAKRLLESKQKIPHLYLSSDVVLDPLLAFRKELQE---NHGV 695
T S IRK IAK ++ SK PH+ L +V + L+A RK+ ++ + G+
Sbjct: 212 ETREK------MSGIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGI 265
Query: 696 KVSVNDIVIKAVAVALRNVRHANAFWDAEKGEIVLCEDVDISIAVATEKGLMTPIIRNAD 875
K++ V+KA+ AL+ N D + E++ +I IA TEKGL+ P+++NAD
Sbjct: 266 KLTYLPYVVKALTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNAD 325
Query: 876 QKSISAISSEVKELAQKARSGKLAPHEFQGGTFSISNLGMYPVDQFCAIINPPQAGILAV 1055
+KS+ IS E+ LA KAR GKLAP E +G + +I+N+G F +IN P+ IL +
Sbjct: 326 RKSVFEISDEINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGI 385
Query: 1056 GRGNKVVEAVLGIDGTEKPSVVTKMNVTLSADHRIFDGQVGASFLSELRSNFED 1217
GR + E + DG + V + ++LS DHR+ DG + L+ ++ D
Sbjct: 386 GR---IAEKAIVRDGEIVAAPV--LALSLSFDHRMIDGATAQNALNHIKRLLND 434
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,471,325,924
Number of Sequences: 518415
Number of Extensions: 72471325924
Number of Successful Extensions: 505334272
Number of sequences better than 0.0: 0
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