BLASTX 7.6.2
Query= UN18043 /QuerySize=1579
(1578 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9LYT3|TT12_ARATH Protein TRANSPARENT TESTA 12 OS=Arabidopsis... 314 2e-084
sp|Q96FL8|S47A1_HUMAN Multidrug and toxin extrusion protein 1 OS... 182 7e-045
sp|Q5RFD2|S47A1_PONAB Multidrug and toxin extrusion protein 1 OS... 179 4e-044
sp|A1L1P9|S47A1_DANRE Multidrug and toxin extrusion protein 1 OS... 179 6e-044
sp|Q3V050|S47A2_MOUSE Multidrug and toxin extrusion protein 2 OS... 176 5e-043
sp|Q10085|YAO6_SCHPO Uncharacterized transporter C11D3.06 OS=Sch... 154 3e-036
sp|A7KAU3|S47A2_RABIT Multidrug and toxin extrusion protein 2 OS... 142 1e-032
sp|Q9UT92|YL47_SCHPO Uncharacterized transporter C323.07c OS=Sch... 125 1e-027
sp|Q9K015|NORM_NEIMB Probable multidrug resistance protein norM ... 105 1e-021
sp|Q9JV27|NORM_NEIMA Probable multidrug resistance protein norM ... 104 3e-021
sp|Q86VL8|S47A2_HUMAN Multidrug and toxin extrusion protein 2 OS... 98 2e-019
sp|Q5R7E4|S47A2_PONAB Multidrug and toxin extrusion protein 2 OS... 73 6e-012
>sp|Q9LYT3|TT12_ARATH Protein TRANSPARENT TESTA 12 OS=Arabidopsis thaliana
GN=TT12 PE=2 SV=1
Length = 507
Score = 314 bits (802), Expect = 2e-084
Identities = 163/413 (39%), Positives = 251/413 (60%), Gaps = 2/413 (0%)
Frame = -3
Query: 1420 ESAKMWLIAAPVGFNVICQYGVSSVTNIFVGHIGEIELSAVSISLSVIGTFSFGFLLGMG 1241
ES +W ++ + Y +S VT +F GH+G ++L+ SI+ I ++G +LGM
Sbjct: 51 ESKLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVGIQGLAYGIMLGMA 110
Query: 1240 SALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCLFLLPIYIFATPVLRLLGQAEEIAVP 1061
SA++T+CGQA+GA Q +G+ QR+ ++ + +FL +Y ++ P+L+ +GQ+ IA
Sbjct: 111 SAVQTVCGQAYGARQYSSMGIICQRAMVLHLAAAVFLTFLYWYSGPILKTMGQSVAIAHE 170
Query: 1060 AGQFTLLTIPQLFSMAFNFPTSKFLQAQSKVTVIAWIGFIALLLHVGMLWLFIIVFGLGT 881
F IPQ+++ A P +FLQAQ+ V +A++ LLH + WL V G
Sbjct: 171 GQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTWLVTNVLDFGL 230
Query: 880 NGAALAFNITNWGIAISQIVYVI--GWCNDGWTGLSWLAFKEIWAFVRLSIASAVMLCLE 707
GAAL + + W + +Y++ C + WTG S AF+ IW + +L++ASAVMLCLE
Sbjct: 231 LGAALILSFSWWLLVAVNGMYILMSPNCKETWTGFSTRAFRGIWPYFKLTVASAVMLCLE 290
Query: 706 MWYMMSIIVLTGHLDNAVIAVGSLSICMNLNGLEAMLFIGINAAISVRVSNELGLGRPRA 527
+WY +++++G L N I++ ++SICM + +G++AAISVRVSNELG G PR
Sbjct: 291 IWYNQGLVIISGLLSNPTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRV 350
Query: 526 AKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIFTNSEVLQRAVFKLAYLLGITMVLNSV 347
A SV V ++LI V V +++ R + FT+ + AV L LL +++ LN +
Sbjct: 351 AMLSVVVVNITTVLISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGI 410
Query: 346 QPVISGVAIGGG*QGLVAYINLGCYYIFGLPFGYLLGYKANLGVMGLWAGMIA 188
QP++SGVAIG G Q +VAY+NL YY+ GLP G +LG+K +LGV G+W GMIA
Sbjct: 411 QPILSGVAIGSGWQAVVAYVNLVTYYVIGLPIGCVLGFKTSLGVAGIWWGMIA 463
>sp|Q96FL8|S47A1_HUMAN Multidrug and toxin extrusion protein 1 OS=Homo sapiens
GN=SLC47A1 PE=1 SV=1
Length = 570
Score = 182 bits (461), Expect = 7e-045
Identities = 124/427 (29%), Positives = 215/427 (50%), Gaps = 6/427 (1%)
Frame = -3
Query: 1420 ESAKMWLIAAPVGFNVICQYGVSSVTNIFVGHIGEIELSAVSISLSVIGTFSFGFLLGMG 1241
E + ++A P + + +S ++++F GH+G++EL AV+++++VI G+
Sbjct: 34 ELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLS 93
Query: 1240 SALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCLFLLPIYIFATPVLRLLGQAEEIAVP 1061
SA +TL Q +G+ + +GV +QRS ++L + C +++ +L L Q +++
Sbjct: 94 SACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRL 153
Query: 1060 AGQFTLLTIPQLFSMAFNFPTSKFLQAQSKVTVIAWIGFIALLLHVGMLWLFIIVFGLGT 881
+ + IP L + K+L Q V G A L++ +LF+ LG
Sbjct: 154 TQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGV 213
Query: 880 NGAALAFNITNWGIAISQIVYVIG--WCNDGWTGLSWLAFKEIWAFVRLSIASAVMLCLE 707
G+ALA I+ + +A+ +Y++G W G S ++ +F+RL+I S +MLC+E
Sbjct: 214 IGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCME 273
Query: 706 MWYMMSIIVLTGHLDNAVIAVGSLSICMNLNGLEAMLFIGINAAISVRVSNELGLGRPRA 527
W L+G L ++ +G+ SI L + M+ G + A SVRV N LG G
Sbjct: 274 WWAYEVGSFLSGIL--GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQ 331
Query: 526 AKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIFTNSEVLQRAVFKLAYLLGITMVLNSV 347
A+ S V++ ++L + F V ++ +DH IFT + V ++ + ++ + ++
Sbjct: 332 ARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEAL 391
Query: 346 QPVISGVAIGGG*QGLVAYINLGCYYIFGLPFGYLLGYKANLGVMGLWAGMIAETTSKEV 167
GV G G Q + A +N YY+ GLP G L + LGVMGLW+G+I T + V
Sbjct: 392 ACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAV 451
Query: 166 VA*LLGF 146
LGF
Sbjct: 452 C--FLGF 456
>sp|Q5RFD2|S47A1_PONAB Multidrug and toxin extrusion protein 1 OS=Pongo abelii
GN=SLC47A1 PE=2 SV=1
Length = 570
Score = 179 bits (454), Expect = 4e-044
Identities = 123/427 (28%), Positives = 213/427 (49%), Gaps = 6/427 (1%)
Frame = -3
Query: 1420 ESAKMWLIAAPVGFNVICQYGVSSVTNIFVGHIGEIELSAVSISLSVIGTFSFGFLLGMG 1241
E + ++A P + + +S ++++F GH+G++EL AV+++++VI G+
Sbjct: 34 ELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLS 93
Query: 1240 SALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCLFLLPIYIFATPVLRLLGQAEEIAVP 1061
SA +TL Q +G+ + +GV +QRS +IL + C +++ +L L Q +++
Sbjct: 94 SACDTLISQTYGSQNLKHVGVILQRSALILLLCCFPCWALFLNTQHILLLFRQDPDVSRL 153
Query: 1060 AGQFTLLTIPQLFSMAFNFPTSKFLQAQSKVTVIAWIGFIALLLHVGMLWLFIIVFGLGT 881
+ + IP L + K+L Q V G A L++ +LF+ LG
Sbjct: 154 TQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGA 213
Query: 880 NGAALAFNITNWGIAISQIVYVIG--WCNDGWTGLSWLAFKEIWAFVRLSIASAVMLCLE 707
G+ALA I+ + +A+ Y++G W G S ++ +F+ L++ S +MLC+E
Sbjct: 214 IGSALANLISQYTLALLLFFYILGKKLHQATWGGWSLECLQDWASFLHLAVPSMLMLCME 273
Query: 706 MWYMMSIIVLTGHLDNAVIAVGSLSICMNLNGLEAMLFIGINAAISVRVSNELGLGRPRA 527
W L+G L ++ +G+ SI L + M+ G + A SVRV N LG G
Sbjct: 274 WWAYEVGSFLSGIL--GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQ 331
Query: 526 AKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIFTNSEVLQRAVFKLAYLLGITMVLNSV 347
A+ S V++ ++L + F V ++ +DH IFT + V ++ + ++ + ++
Sbjct: 332 ARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEAL 391
Query: 346 QPVISGVAIGGG*QGLVAYINLGCYYIFGLPFGYLLGYKANLGVMGLWAGMIAETTSKEV 167
GV G G Q + A +N YY+ GLP G L + LGVMGLW+G+I T + V
Sbjct: 392 ACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATKLGVMGLWSGIIICTVFQAV 451
Query: 166 VA*LLGF 146
LGF
Sbjct: 452 C--FLGF 456
>sp|A1L1P9|S47A1_DANRE Multidrug and toxin extrusion protein 1 OS=Danio rerio
GN=slc47a1 PE=2 SV=1
Length = 590
Score = 179 bits (453), Expect = 6e-044
Identities = 119/412 (28%), Positives = 202/412 (49%), Gaps = 6/412 (1%)
Frame = -3
Query: 1423 TESAKMWLIAAPVGFNVICQYGVSSVTNIFVGHIGEIELSAVSISLSVIGTFSFGFLLGM 1244
TE ++ +A PV + + + +S V+ +F GH+G+ EL+ V+++++VI G+
Sbjct: 51 TEIVELLKLAGPVFISQLMIFLISFVSTVFCGHLGKTELAGVALAIAVINVTGISIGSGL 110
Query: 1243 GSALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCLFLLPIYIFATPVLRLLGQAEEIAV 1064
SA +TL Q FG+ + +GV +QR +IL ++C + I P+L + Q+ +A
Sbjct: 111 ASACDTLISQTFGSNNLKRVGVILQRGILILLLACFPCWALLINTEPILLAVRQSPNVAS 170
Query: 1063 PAGQFTLLTIPQLFSMAFNFPTSKFLQAQSKVTVIAWIGFIALLLHVGMLWLFIIVFGLG 884
+ + + +P L + ++LQ Q + G +L+ + ++F+ + LG
Sbjct: 171 LSQLYVKIFMPALPAAFMYQLQGRYLQNQGIIWPQVITGAAGNILNALINYVFLHLLELG 230
Query: 883 TNGAALAFNITNWGIAISQIVYVIGWCN---DGWTGLSWLAFKEIWAFVRLSIASAVMLC 713
G+A A I+ + +A+ VY I W N W G S +E AF+RL++ S +MLC
Sbjct: 231 VAGSAAANTISQYSLAVFLYVY-IRWKNLHKATWDGWSRDCLQEWGAFIRLALPSMLMLC 289
Query: 712 LEMWYMMSIIVLTGHLDNAVIAVGSLSICMNLNGLEAMLFIGINAAISVRVSNELGLGRP 533
+E W L G + +G+ S+ L + M +G A SVRV N LG G
Sbjct: 290 VEWWTYEIGGFLAGLISET--ELGAQSVVYELATIAYMFPLGFAVAASVRVGNALGAGNT 347
Query: 532 RAAKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIFTNSEVLQRAVFKLAYLLGITMVLN 353
AK S V + +L+ V I +D A IFT E + V ++ + G + +
Sbjct: 348 ERAKLSAKVALVCGVLVSCVVATLIGCTKDVIAYIFTTEEEIVSRVSQVMIMYGFFHLFD 407
Query: 352 SVQPVISGVAIGGG*QGLVAYINLGCYYIFGLPFGYLLGYKANLGVMGLWAG 197
++ + G+ G G Q L A N+ YY G P G L + ++G++GLW G
Sbjct: 408 AIAGITGGIVRGAGKQLLGALCNIVGYYFVGFPTGVSLMFALSMGIIGLWIG 459
>sp|Q3V050|S47A2_MOUSE Multidrug and toxin extrusion protein 2 OS=Mus musculus
GN=Slc47a2 PE=1 SV=1
Length = 573
Score = 176 bits (445), Expect = 5e-043
Identities = 126/423 (29%), Positives = 213/423 (50%), Gaps = 14/423 (3%)
Frame = -3
Query: 1444 DVKRVLCTESAKMWLIAAPVGFNVICQYGVSSVTNIFVGHIGEIELSAVSISLSVIGTFS 1265
DV+R E+A + +A PV + + +S V++IF GH+G++EL AV++++SV+
Sbjct: 39 DVRR----EAAALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTG 94
Query: 1264 FGFLLGMGSALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCLFLLPIYIFATPVLRLLG 1085
G+ SA +TL Q+FG + +GV +QR +IL + C I++ +L LL
Sbjct: 95 ISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILILLLCCFPCWAIFLNTERLLLLLR 154
Query: 1084 QAEEIAVPAGQFTLLTIPQLFSMAFNFP-TSKFLQAQSKVTVIAWIGFIALLLHVGMLWL 908
Q ++A A + ++ IP L AF F +++LQ+Q + +G A +++VGM
Sbjct: 155 QDPDVARLAQVYVMICIPAL-PAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAF 213
Query: 907 FIIVFGLGTNGAALAFNITNWGIAISQIVYVIGWCN----DGWTGLSWLAFKEIWAFVRL 740
+ LG G+A A + + ++ +YV W W G + F+E ++ RL
Sbjct: 214 LLYALDLGVVGSAWANTTSQFFLSALLFLYV--WWKRIHIHTWGGWTRECFQEWSSYTRL 271
Query: 739 SIASAVMLCLEMWYMMSIIVLTGHLDNAVIAVGSLSICMNLNGLEAMLFIGINAAISVRV 560
+I S M+C+E W L G ++ V +G+ ++ L + M+ G A SVRV
Sbjct: 272 AIPSMFMVCIEWWTFEIGTFLAGLVN--VTELGAQAVIYELASVAYMVPFGFGVAASVRV 329
Query: 559 SNELGLGRPRAAKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIFTNSEVLQRAVFKLAY 380
N LG G A+ S + + + L+ + + +D A IFTN + + V ++
Sbjct: 330 GNALGAGNADQARCSCTTVLLCAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMP 389
Query: 379 LLGITMVLNSVQPVISGVAIGGG*QGLVAYINLGCYYIFGLPFGYLLGYKANLGVMGLWA 200
+ + +++ GV G G Q + A +N YY FG P G L + A LG++GLWA
Sbjct: 390 IFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVSLMFAAKLGIIGLWA 449
Query: 199 GMI 191
G+I
Sbjct: 450 GLI 452
>sp|Q10085|YAO6_SCHPO Uncharacterized transporter C11D3.06
OS=Schizosaccharomyces pombe GN=SPAC11D3.06 PE=2 SV=1
Length = 455
Score = 154 bits (387), Expect = 3e-036
Identities = 114/416 (27%), Positives = 197/416 (47%), Gaps = 12/416 (2%)
Frame = -3
Query: 1423 TESAKMWLIAAPVGFNVICQYGVSSVTNIFVGHIGEIELSAVSISLSVIGTFSFGFLLGM 1244
TE + + +APV Q + + + I G +G ELS + + + S G+L+ +
Sbjct: 6 TEVKYLLINSAPVILGYALQNSLQTSSVIVTGRLGPSELSVA--AFAYMFAMSTGWLIAL 63
Query: 1243 G--SALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCLFLLPIYIFATPVLRLLGQAEEI 1070
G +A +TL +GAG+ LG+ +Q +I+L + L + ++ ++ P+L L Q E+
Sbjct: 64 GGTTAFDTLGSNLWGAGKKQELGILLQTGFIVLSILYLPICLVWWYSKPILIFLHQTPEL 123
Query: 1069 AVPAGQFTLLTIPQLFSMAFNFPTSKFLQAQSKVTVIAWIGFIALLLHVGMLWLFIIVFG 890
A + +F IP KFLQ Q ++I + L+V + +L + +G
Sbjct: 124 AEASQKFLRYLIPGGLGYVCFELLKKFLQTQEITRAGSYILLVTSPLNVALNFLLVHYYG 183
Query: 889 LGTNGAALAFNITNW--GIAISQIV-YVIGWCNDGWTGLSWLAFKEIWAFVRLSIASAVM 719
LG GA LA ++ W I ++Q YV G + W G + + FV+LS+ VM
Sbjct: 184 LGLKGAPLATGLSYWLSFILLTQYAKYVKG--AEAWNGWNKRCLENFGPFVKLSLLGIVM 241
Query: 718 LCLEMWYMMSIIVLTGHLDNAVIAVGSLSICMNLNGLEAMLFIGINAAISVRVSNELGLG 539
+ E W + ++ G L + + + S+ M + L + G+ S RV+ LG G
Sbjct: 242 VGTEWWAFEIVALVAGKL--GAVPLAAQSVIMTTDQLLNTIPFGLGIITSNRVAYYLGAG 299
Query: 538 RPRAAKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIFTNSEVLQRAVFKLAYLLGITMV 359
P A + V + +G V M+ +I R+ + IFTN + + V + L+ +
Sbjct: 300 LPDNASLTAKVAAIVGVAVGSVIMITMIAVRNIYGRIFTNDPDVIQLVALVMPLVAAFQI 359
Query: 358 LNSVQPVISGVAIGGG*QGLVAYINLGCYYIFGLPFGYLLGYKANLGVMGLWAGMI 191
+S+ + G G G Q + A +N+ YY+F LP G L + G++GLW G +
Sbjct: 360 SDSLNGTMGGALRGTGRQKVGAIVNITAYYLFALPLGIYLAFHGK-GLVGLWIGQV 414
>sp|A7KAU3|S47A2_RABIT Multidrug and toxin extrusion protein 2 OS=Oryctolagus
cuniculus GN=SLC47A2 PE=1 SV=1
Length = 601
Score = 142 bits (356), Expect = 1e-032
Identities = 103/412 (25%), Positives = 192/412 (46%), Gaps = 4/412 (0%)
Frame = -3
Query: 1420 ESAKMWLIAAPVGFNVICQYGVSSVTNIFVGHIGEIELSAVSISLSVIGTFSFGFLLGMG 1241
E+ +++++ P+ + + V +F GH+G++EL++V++ ++ + G+
Sbjct: 59 EARALFVLSGPLFLFQVLNFLTYVVGTVFCGHLGKVELASVTLGVAFVNVCGVSVGAGLS 118
Query: 1240 SALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCLFLLPIYIFATPVLRLLGQAEEIAVP 1061
SA +TL Q+FG+ +GV +QR +IL + CL +++ +L L Q ++
Sbjct: 119 SACDTLMSQSFGSPNKKHVGVILQRGSLILLLCCLPCWALFLNTQHILLLFRQDPAVSRL 178
Query: 1060 AGQFTLLTIPQLFSMAFNFPTSKFLQAQSKVTVIAWIGFIALLLHVGMLWLFIIVFGLGT 881
+ ++ IP L ++ +K+LQ Q V G + ++ + + V LG
Sbjct: 179 TQDYAMIFIPGLPAIFLYSLLAKYLQNQGIVWPQVLSGVVGNCVNGVANYALVSVLNLGV 238
Query: 880 NGAALAFNITNWGIAISQIVYVI--GWCNDGWTGLSWLAFKEIWAFVRLSIASAVMLCLE 707
G+A A I+ + A ++++ + W G S ++ F+ L+I S +M+C+E
Sbjct: 239 RGSAYANTISQFVQAAFLFLHIVLKKLHLETWEGWSSQCLRDWGPFLSLAIPSMLMMCVE 298
Query: 706 MWYMMSIIVLTGHLDNAVIAVGSLSICMNLNGLEAMLFIGINAAISVRVSNELGLGRPRA 527
W L G L V+ + +I + + M+ +G+ A+ VRV LG
Sbjct: 299 WWAYEIGSFLMGLL--GVVDLSGQAIIYEVATVVYMIPMGLGMAVCVRVGTALGAADTLQ 356
Query: 526 AKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIFTNSEVLQRAVFKLAYLLGITMVLNSV 347
AK S + + LV + + IFT+ E + V ++ + + ++ +V
Sbjct: 357 AKRSAVSGLLCTAGTSLVVGTLLGLLNSQLGYIFTSDEEVIALVNQVLPIYIVFQLVEAV 416
Query: 346 QPVISGVAIGGG*QGLVAYINLGCYYIFGLPFGYLLGYKANLGVMGLWAGMI 191
V GV G G Q A +N YYI GLP G +L + + +MGLW GM+
Sbjct: 417 CCVFGGVLRGTGKQAFGAIVNAIMYYIVGLPLGIVLTFVVGMRIMGLWLGML 468
>sp|Q9UT92|YL47_SCHPO Uncharacterized transporter C323.07c
OS=Schizosaccharomyces pombe GN=SPAC323.07c PE=1 SV=1
Length = 533
Score = 125 bits (312), Expect = 1e-027
Identities = 111/423 (26%), Positives = 189/423 (44%), Gaps = 7/423 (1%)
Frame = -3
Query: 1432 VLCTESAKMWLIAAPVGFNVICQYGVSSVTNIFVGHIGEIELSAVSISLSVIGTFSFGFL 1253
V+ E +++ + +P + Q T +GH+G+ L+A S+S +F
Sbjct: 86 VIKHELSELLRLGSPTVIAYLLQSSEQFSTVFTLGHLGKEYLAASSLSTMTAAISAFSIF 145
Query: 1252 LGMGSALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCLFLLPIYIFATPVLRLLGQAEE 1073
G+ S+L+TL QAFGA + + + +Y+QR +IL V + + I++ +L L Q
Sbjct: 146 QGVISSLDTLATQAFGANKPYNVAIYLQRCLLILAVLHIPVALIWLNLEHILIFLHQDPM 205
Query: 1072 IAVPAGQFTLLTIPQLFSMAFNFPTSKFLQAQSKVTVIAWIGFIALLLHVGMLWLFI--I 899
+A G++ + I A ++LQAQ T I ++ A L++ + +L +
Sbjct: 206 VAHLCGRYMRVFILAAPGYAVFEALKRYLQAQGIFTPITYVLCFAAPLNILLNYLLVWHP 265
Query: 898 VFGLGTNGAALAFNITNWGIAISQIVYV-IGWCNDGWTGLSWLAFKEIWAFVRLSIASAV 722
G G GA +A T W +I I+Y+ W G S A K + + S +
Sbjct: 266 TIGFGFLGAPVAVATTFWFQSICLILYICFSSTPIPWPGFSRQALKNLSPMLHFSFHGML 325
Query: 721 MLCLEMWYMMSIIVL-TGHLDNAVIAVGSLSICMNLNGLEAMLFIGINAAISVRVSNELG 545
M+ E W + L G+L A +A S SI + L + A S RV + +G
Sbjct: 326 MIVTE-WAAYEMTSLGAGYLGTAPLA--SQSILLTSTSLLFQIPFAFAVASSTRVGHLIG 382
Query: 544 LGRPRAAKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIFTNSEVLQRAVFKLAYLLGIT 365
GR A+ V +L I + I RD + +FT+ + V + +L +
Sbjct: 383 SGRANLARLCSRVAYSLALCISIFDGSLIFCFRDVWGSLFTSDPEVLAVVKDIFPILSLF 442
Query: 364 MVLNSVQPVISGVAIGGG*QGLVAYINLGCYYIFGLPFGYLLGYKANLGVMGLWAGMIAE 185
+V + + V G+ G G Q + I++G Y+F LP + N G+ G+W GMI
Sbjct: 443 IVTDGLNAVGGGLLRGTGKQYIGGLISIGSSYLFALPVTVFVVVYFNTGLKGIWCGMILS 502
Query: 184 TTS 176
+ +
Sbjct: 503 SVT 505
>sp|Q9K015|NORM_NEIMB Probable multidrug resistance protein norM OS=Neisseria
meningitidis serogroup B GN=norM PE=3 SV=1
Length = 459
Score = 105 bits (260), Expect = 1e-021
Identities = 94/430 (21%), Positives = 185/430 (43%), Gaps = 18/430 (4%)
Frame = -3
Query: 1432 VLCTESAKMWLIAAPVGFNVICQYGVSSVTNIFVGHIGEIELSAVSISLSVIGTFSFGFL 1253
V E + +A P+ + Q G+ V + G G+ +L+AV++ S T F
Sbjct: 12 VFLKEVRLLTTLALPMLLAQVAQVGIGFVDTVMAGGAGKEDLAAVALGSSAFATVYITF- 70
Query: 1252 LGMGSALETLCGQAFGAGQVHMLG-VYMQRSWIILFVSCLFLLPIYIFATPVLRLLGQAE 1076
+G+ +AL + Q +GAG+ +G Q W LF+ ++ ++ TP L ++
Sbjct: 71 MGIMAALNPMIAQLYGAGKTDEVGETGRQGIWFGLFLGVFGMVLMWAAITPFRNWLTLSD 130
Query: 1075 EIAVPAGQFTLLTIPQLFSMAFNFPTSKFLQAQSKVTVIAWIGFIALLLHVGMLWLFII- 899
+ Q+ L T + + + + + ++ +I + F A +L+V + ++F+
Sbjct: 131 YVEGTMAQYMLFTSLAMPAAMVHRALHAYTSSLNRPRLIMLVSFAAFVLNVPLNYIFVYG 190
Query: 898 VFG---LGTNGAALAFNITNWGIAISQIVYVIGWCNDGWTGLS-------WLAFKEIWAF 749
FG LG G LA W A++ +Y+ GL+ W FK+IW
Sbjct: 191 KFGMPALGGAGCGLATMAVFWFSALALWIYIAKENFFRPFGLTAKFGKPDWAVFKQIW-- 248
Query: 748 VRLSIASAVMLCLEMWYMMSIIVLTGHLDNAVIAVGSLSICMNLNGLEAMLFIGINAAIS 569
++ + LE I+ L +A + I +L+G+ M+ + +A +
Sbjct: 249 -KIGAPIGLSYFLEASAFSFIVFLIAPFGEDYVAAQQVGI--SLSGILYMIPQSVGSAGT 305
Query: 568 VRVSNELGLGRPRAAKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIFTNSEVLQRAVFK 389
VR+ LG A+Y V++ ++ ++ ++++++ R ++ N +
Sbjct: 306 VRIGFSLGRREFSRARYISGVSLVLGWMLAVITVLSLVLFRSPLVSMYNNDPAVLSIAAT 365
Query: 388 LAYLLGITMVLNSVQPVISGVAIGGG*QGLVAYINLGCYYIFGLPFGYLLGYKANLGVMG 209
+ G+ + Q + S G + +I+ ++ GL GYLL Y+ N+G+ G
Sbjct: 366 VLLFAGLFQPADFTQCIASYALRGYKVTKVPMFIHAAAFWGCGLLPGYLLAYRFNMGIYG 425
Query: 208 LWAGMIAETT 179
W +IA T
Sbjct: 426 FWTALIASLT 435
>sp|Q9JV27|NORM_NEIMA Probable multidrug resistance protein norM OS=Neisseria
meningitidis serogroup A GN=norM PE=3 SV=1
Length = 459
Score = 104 bits (257), Expect = 3e-021
Identities = 93/430 (21%), Positives = 185/430 (43%), Gaps = 18/430 (4%)
Frame = -3
Query: 1432 VLCTESAKMWLIAAPVGFNVICQYGVSSVTNIFVGHIGEIELSAVSISLSVIGTFSFGFL 1253
V E + +A P+ + Q G+ V + G G+ +L+AV++ S T F
Sbjct: 12 VFLKEVRLLTALALPMLLAQVAQVGIGFVDTVMAGGAGKEDLAAVALGSSAFATVYITF- 70
Query: 1252 LGMGSALETLCGQAFGAGQVHMLG-VYMQRSWIILFVSCLFLLPIYIFATPVLRLLGQAE 1076
+G+ +AL + Q +GAG+ +G Q W LF+ ++ ++ TP L ++
Sbjct: 71 MGIMAALNPMIAQLYGAGKTDEVGETGRQGIWFGLFLGVFGMVLMWAAITPFRNWLTLSD 130
Query: 1075 EIAVPAGQFTLLTIPQLFSMAFNFPTSKFLQAQSKVTVIAWIGFIALLLHVGMLWLFII- 899
+ Q+ L T + + + + + ++ +I + F A +L+V + ++F+
Sbjct: 131 YVEGTMAQYMLFTSLAMPAAMVHRALHAYASSLNRPRLIMLVSFAAFVLNVPLNYIFVYG 190
Query: 898 VFG---LGTNGAALAFNITNWGIAISQIVYVIGWCNDGWTGLS-------WLAFKEIWAF 749
FG LG G LA W A++ +Y+ GL+ W FK+IW
Sbjct: 191 KFGMPALGGAGCGLATMAVFWFSALALWIYIAKENFFRPFGLTAKFGKPDWAVFKQIW-- 248
Query: 748 VRLSIASAVMLCLEMWYMMSIIVLTGHLDNAVIAVGSLSICMNLNGLEAMLFIGINAAIS 569
++ + LE I+ L +A + I +L+G+ M+ + +A +
Sbjct: 249 -KIGAPIGLSYFLEASAFSFIVFLIAPFGEDYVAAQQVGI--SLSGILYMIPQSVGSAGT 305
Query: 568 VRVSNELGLGRPRAAKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIFTNSEVLQRAVFK 389
VR+ LG A+Y V++ ++ ++ ++++++ R ++ N +
Sbjct: 306 VRIGFSLGRREFSRARYISGVSLVSGWMLAVITVLSLVLFRSPLVSMYNNDPAVLSIAAT 365
Query: 388 LAYLLGITMVLNSVQPVISGVAIGGG*QGLVAYINLGCYYIFGLPFGYLLGYKANLGVMG 209
+ G+ + Q + S G + +I+ ++ GL GYLL Y+ ++G+ G
Sbjct: 366 VLLFAGLFQPADFTQCIASYALRGYKVTKVPMFIHAAAFWGCGLLPGYLLAYRFDMGIYG 425
Query: 208 LWAGMIAETT 179
W +IA T
Sbjct: 426 FWTALIASLT 435
>sp|Q86VL8|S47A2_HUMAN Multidrug and toxin extrusion protein 2 OS=Homo sapiens
GN=SLC47A2 PE=1 SV=1
Length = 602
Score = 98 bits (242), Expect = 2e-019
Identities = 69/244 (28%), Positives = 115/244 (47%), Gaps = 4/244 (1%)
Frame = -3
Query: 913 WLFIIVFGLGTNGAALAFNITNWGIAISQIVYVI--GWCNDGWTGLSWLAFKEIWAFVRL 740
+ + V LG G+A A I+ + + ++Y++ + W G S ++ F L
Sbjct: 235 YALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSL 294
Query: 739 SIASAVMLCLEMWYMMSIIVLTGHLDNAVIAVGSLSICMNLNGLEAMLFIGINAAISVRV 560
++ S +M+C+E W L G L +V+ + + ++ + + M+ +G++ + VRV
Sbjct: 295 AVPSMLMICVEWWAYEIGSFLMGLL--SVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRV 352
Query: 559 SNELGLGRPRAAKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIFTNSEVLQRAVFKLAY 380
LG AK S V + I LV I I ++ IFTN E + V ++
Sbjct: 353 GMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLP 412
Query: 379 LLGITMVLNSVQPVISGVAIGGG*QGLVAYINLGCYYIFGLPFGYLLGYKANLGVMGLWA 200
+ + V ++ V GV G G Q A +N YYI GLP G LL + + +MGLW
Sbjct: 413 VYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWL 472
Query: 199 GMIA 188
GM+A
Sbjct: 473 GMLA 476
>sp|Q5R7E4|S47A2_PONAB Multidrug and toxin extrusion protein 2 OS=Pongo abelii
GN=SLC47A2 PE=2 SV=1
Length = 581
Score = 73 bits (177), Expect = 6e-012
Identities = 47/139 (33%), Positives = 67/139 (48%)
Frame = -3
Query: 604 AMLFIGINAAISVRVSNELGLGRPRAAKYSVYVTVFQSLLIGLVFMVAIIIARDHFAIIF 425
A + +G++ + VRV LG AK S V + I LV I I ++ IF
Sbjct: 316 ARIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIF 375
Query: 424 TNSEVLQRAVFKLAYLLGITMVLNSVQPVISGVAIGGG*QGLVAYINLGCYYIFGLPFGY 245
TN E + V ++ + + V ++ V GV G G Q A +N YYI GLP G
Sbjct: 376 TNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGI 435
Query: 244 LLGYKANLGVMGLWAGMIA 188
LL + + +MGLW GM+A
Sbjct: 436 LLTFVVRMRIMGLWLGMLA 454
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,436,365,428
Number of Sequences: 518415
Number of Extensions: 75436365428
Number of Successful Extensions: 513409628
Number of sequences better than 0.0: 0
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