BLASTX 7.6.2
Query= UN18093 /QuerySize=1837
(1836 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P93846|CP51_SORBI Obtusifoliol 14-alpha demethylase OS=Sorghu... 768 3e-221
sp|P93596|CP51_WHEAT Obtusifoliol 14-alpha demethylase (Fragment... 763 1e-219
sp|Q1ZXH9|CP51_DICDI Probable lanosterol 14-alpha demethylase OS... 371 2e-101
sp|Q4PJW3|CP51A_BOVIN Lanosterol 14-alpha demethylase OS=Bos tau... 325 6e-088
sp|Q8K0C4|CP51A_MOUSE Lanosterol 14-alpha demethylase OS=Mus mus... 318 1e-085
sp|Q64654|CP51A_RAT Lanosterol 14-alpha demethylase OS=Rattus no... 316 5e-085
sp|Q5RE72|CP51A_PONAB Lanosterol 14-alpha demethylase OS=Pongo a... 313 4e-084
sp|Q16850|CP51A_HUMAN Lanosterol 14-alpha demethylase OS=Homo sa... 312 5e-084
sp|Q4R8S6|CP51A_MACFA Lanosterol 14-alpha demethylase OS=Macaca ... 312 5e-084
sp|O46420|CP51A_PIG Lanosterol 14-alpha demethylase OS=Sus scrof... 312 5e-084
sp|P0A513|CP51_MYCBO Lanosterol 14-alpha demethylase OS=Mycobact... 278 1e-073
sp|P0A512|CP51_MYCTU Lanosterol 14-alpha demethylase OS=Mycobact... 278 1e-073
sp|P50859|CP51_CANGA Lanosterol 14-alpha demethylase OS=Candida ... 231 2e-059
sp|Q9UVC3|CP51_CUNEL Lanosterol 14-alpha demethylase OS=Cunningh... 230 3e-059
sp|Q09736|CP51_SCHPO Lanosterol 14-alpha demethylase erg11 OS=Sc... 211 2e-053
sp|P10614|CP51_YEAST Lanosterol 14-alpha demethylase OS=Saccharo... 153 7e-036
sp|Q759W0|CP51_ASHGO Lanosterol 14-alpha demethylase OS=Ashbya g... 152 9e-036
sp|P49602|CP51_USTMA Lanosterol 14-alpha demethylase OS=Ustilago... 84 4e-015
>sp|P93846|CP51_SORBI Obtusifoliol 14-alpha demethylase OS=Sorghum bicolor
GN=CYP51 PE=1 SV=1
Length = 492
Score = 768 bits (1983), Expect = 3e-221
Identities = 367/487 (75%), Positives = 434/487 (89%), Gaps = 3/487 (0%)
Frame = +3
Query: 153 ELDSDKNLLKTGLVVIATLVLAKLIFSFFFKSDSKKKRLPPTLKAWPPLIGSLLRFLKGP 332
++ + L+ +V+AT++ KL+ S F+S KKRLPPT+ P++G L++F++GP
Sbjct: 5 DIPQQQRLMAGLALVVATVIFLKLLLS--FRSGGGKKRLPPTIPG-APVVGGLVKFMRGP 61
Query: 333 IVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVSAHFFKAPESDLSQQEVYQFNVPTFGPG 512
I M+R++Y LGSVFTV ++ +++TFLIGPEVSAHFFK E+++SQQEVY+FNVPTFGPG
Sbjct: 62 IPMIREQYAALGSVFTVPIITRRITFLIGPEVSAHFFKGNEAEMSQQEVYRFNVPTFGPG 121
Query: 513 VVFDVDYTVRQEQFRFFTEALRVNKLKGYVEMMVTEAEDYFSKWGESGEVDLKTELERLI 692
VVFDVDY+VRQEQFRFFTEALR NKL+ YV+ MV EAE+YFSKWGESG VDLK ELE LI
Sbjct: 122 VVFDVDYSVRQEQFRFFTEALRANKLRSYVDQMVAEAEEYFSKWGESGTVDLKYELEHLI 181
Query: 693 ILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVLFPYLPLPAHRRRDRAREKLSEI 872
ILTASRCLLGREVR++LFDDVSALFHDLDNG+ PISVLFPYLP+PAH+RRD+AR +L+EI
Sbjct: 182 ILTASRCLLGREVREKLFDDVSALFHDLDNGIQPISVLFPYLPIPAHKRRDKARARLAEI 241
Query: 873 FAKIIGSRKRSGKSENDMLQCFIESKYKDGRQTTESEVTGLLIAALFAGQHTSSITSTWT 1052
FA II SRK SG+SE DMLQCFI+SKYK+GR TTE EVTGLLIAALFAGQHTSSITSTWT
Sbjct: 242 FATIIKSRKASGQSEEDMLQCFIDSKYKNGRPTTEGEVTGLLIAALFAGQHTSSITSTWT 301
Query: 1053 GAYLMKYGEYFSEALDEQRKLMEKHGDKIDHDILSEMDVLYRCIKEALRLHPPLIMLMRA 1232
GAY++++ +YF+EA++EQ+ +M++HGDKIDHDIL+EMDVLYRCIKEALRLHPPLIML+R
Sbjct: 302 GAYMLRFKQYFAEAVEEQKDVMKRHGDKIDHDILAEMDVLYRCIKEALRLHPPLIMLLRQ 361
Query: 1233 SHSDFSVTARDGKTFDIPKGHIVATSPAFANRLPHIFKNPDSYDPDRFSPGREEDKAAGA 1412
SHSDF+VT ++GK +DIPKGHIVATSP+FANRLPHI+KNPDSYDPDRF PGREEDKAAGA
Sbjct: 362 SHSDFTVTTKEGKEYDIPKGHIVATSPSFANRLPHIYKNPDSYDPDRFGPGREEDKAAGA 421
Query: 1413 FSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELVSPFPEIDWNAMVVGVKGSVMV 1592
FSYISFGGGRHGCLGEPFAYLQIKAIW+HLLRNFE ELVSPFPE DWNAMVVG+KG VMV
Sbjct: 422 FSYISFGGGRHGCLGEPFAYLQIKAIWTHLLRNFEFELVSPFPENDWNAMVVGIKGEVMV 481
Query: 1593 RYKRRQL 1613
YKRR+L
Sbjct: 482 NYKRRKL 488
>sp|P93596|CP51_WHEAT Obtusifoliol 14-alpha demethylase (Fragment) OS=Triticum
aestivum GN=CYP51 PE=2 SV=1
Length = 453
Score = 763 bits (1968), Expect = 1e-219
Identities = 367/448 (81%), Positives = 412/448 (91%), Gaps = 1/448 (0%)
Frame = +3
Query: 270 PPTLKAWPPLIGSLLRFLKGPIVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVSAHFFKA 449
PPT+ P++G LLRFL+GPI ++R EY LG VFTV +L +++TFLIGP+VSAHFFK+
Sbjct: 3 PPTIPG-APVVGGLLRFLRGPIPLIRAEYARLGPVFTVPILTRRITFLIGPDVSAHFFKS 61
Query: 450 PESDLSQQEVYQFNVPTFGPGVVFDVDYTVRQEQFRFFTEALRVNKLKGYVEMMVTEAED 629
ESD+SQQEVY+FNVPTFGPGVVFDVDY VRQEQFRFFTEALR NKL+ YV+ MV EAE+
Sbjct: 62 NESDMSQQEVYRFNVPTFGPGVVFDVDYQVRQEQFRFFTEALRANKLRSYVDQMVAEAEE 121
Query: 630 YFSKWGESGEVDLKTELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVLF 809
YFSKWGESG VDLK ELE LIILTASRCLLGREVR++LFDDVSALFHDLDNGMLPISV+F
Sbjct: 122 YFSKWGESGTVDLKYELEHLIILTASRCLLGREVREKLFDDVSALFHDLDNGMLPISVIF 181
Query: 810 PYLPLPAHRRRDRAREKLSEIFAKIIGSRKRSGKSENDMLQCFIESKYKDGRQTTESEVT 989
PYLP+PAHRRRD+AR +L+EIFA II SRK SG+SE DMLQCFI+SKYK+GRQTTESEVT
Sbjct: 182 PYLPIPAHRRRDQARTRLAEIFATIIKSRKASGQSEEDMLQCFIDSKYKNGRQTTESEVT 241
Query: 990 GLLIAALFAGQHTSSITSTWTGAYLMKYGEYFSEALDEQRKLMEKHGDKIDHDILSEMDV 1169
GLLIAALFAGQHTSSITSTWTGAYL+K+ +YF+EA++EQ+++M++HGDKIDHDIL+EMDV
Sbjct: 242 GLLIAALFAGQHTSSITSTWTGAYLLKFQQYFAEAVEEQKEVMKRHGDKIDHDILAEMDV 301
Query: 1170 LYRCIKEALRLHPPLIMLMRASHSDFSVTARDGKTFDIPKGHIVATSPAFANRLPHIFKN 1349
LYRCIKEALRLHPPLIML+R SHSDFSVT R+GK FDIPKGHIVATSPAFANRLPHIFKN
Sbjct: 302 LYRCIKEALRLHPPLIMLLRQSHSDFSVTTREGKEFDIPKGHIVATSPAFANRLPHIFKN 361
Query: 1350 PDSYDPDRFSPGREEDKAAGAFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELV 1529
PDSYDPDRF+ GREEDK AGAFSYISFGGGRHGCLGEPFAYLQIKAIW+HLLRNFE ELV
Sbjct: 362 PDSYDPDRFAAGREEDKVAGAFSYISFGGGRHGCLGEPFAYLQIKAIWTHLLRNFEFELV 421
Query: 1530 SPFPEIDWNAMVVGVKGSVMVRYKRRQL 1613
SPFPE DWNAMVVG+KG VMV YKRR+L
Sbjct: 422 SPFPENDWNAMVVGIKGEVMVNYKRRKL 449
>sp|Q1ZXH9|CP51_DICDI Probable lanosterol 14-alpha demethylase OS=Dictyostelium
discoideum GN=cyp51 PE=3 SV=1
Length = 466
Score = 371 bits (950), Expect = 2e-101
Identities = 210/471 (44%), Positives = 292/471 (61%), Gaps = 20/471 (4%)
Frame = +3
Query: 198 IATLVLAKLIFSFFFKSDSKKKRLPPTLKAWPPLIGSLLRFLKGPIVMLRDEYPNLGSVF 377
IA LV+A L+ F KS S +PP ++ P IG +F K P+ ++R+ Y LG +F
Sbjct: 5 IAVLVIAILVIFAFKKSPS---NIPPIVET-IPFIGCFYQFAKNPLQLVRNSYDRLGEIF 60
Query: 378 TVNLLHKKMTFLIGPEVSAHFFKAPESDLSQQEVYQFNVPTFGPGVVFDVDYTVRQEQFR 557
T++L+ KMTF++GPE A FF+ + +LS +E Y+F P FG GVV+D + + EQ R
Sbjct: 61 TLHLMGFKMTFVLGPEAQALFFRGTDEELSPKEAYRFVTPVFGKGVVYDSETEIMYEQLR 120
Query: 558 FFTEALRVNKLKGYVEMMVTEAEDYF-SKWGESGEVDLKTELERLIILTASRCLLGREVR 734
F L +++LK V ++ E E YF +KWG+SGE+DL E+ +L ILTASRCL+G+ +
Sbjct: 121 FVKNGLVLSQLKKAVGIIQEETEKYFETKWGDSGEIDLLYEMNKLTILTASRCLMGKSIN 180
Query: 735 DQL--FDDVSALFHDLDNGMLPISVLFPYLPLPAHRRRDRAREKLSEIFAKIIGSRKRS- 905
L ++ L+H+L+ G+ PIS FP LPLP+ ++RD AR K++ IF II R+RS
Sbjct: 181 KSLGQSGQLADLYHELEEGLNPISFFFPNLPLPSFKKRDAARAKVAAIFHSIIQERRRST 240
Query: 906 GKSENDMLQCFIESKYKDGRQTTESEVTGLLIAALFAGQHTSSITSTWTGAYLMKYGEYF 1085
S +D+L + SKYKDG + ++ GL+I LFAGQHTSSIT T+T YL+ EYF
Sbjct: 241 DDSVDDVLYTLMNSKYKDGSVLEDEQIVGLMIGLLFAGQHTSSITLTYTIFYLLNNLEYF 300
Query: 1086 SEALDEQRKLMEKHGD-KIDHDILSEMDVLYRCIKEALRLHPPLIMLMRASHSDFSVTAR 1262
E + +++K +I+ D L M+ L I+E LRLHPPLI LMR +T
Sbjct: 301 DETQKDINDIVQKENQGEINFDGLKRMNRLETVIREVLRLHPPLIFLMRK-----VMTPM 355
Query: 1263 DGKTFDIPKGHIVATSPAFANRLPHIFKNPDSYDPDRFSPGREEDKAAGAFSYISFGGGR 1442
+ K IP GHI+A SP RLP ++KNPDS++P RF EDK FS+I+FGGG+
Sbjct: 356 EYKGKTIPAGHILAVSPQVGMRLPTVYKNPDSFEPKRFD---VEDKT--PFSFIAFGGGK 410
Query: 1443 HGCLGEPFAYLQIKAIWSHLLRNFELELVSPFPEIDWNAMVVGVKGSVMVR 1595
HGC GE F LQIK IW+ L + LE V P P D+ ++V G KG MV+
Sbjct: 411 HGCPGENFGILQIKTIWTVLSTKYNLE-VGPVPPTDFTSLVAGPKGPCMVK 460
>sp|Q4PJW3|CP51A_BOVIN Lanosterol 14-alpha demethylase OS=Bos taurus GN=CYP51A1
PE=2 SV=1
Length = 502
Score = 325 bits (833), Expect = 6e-088
Identities = 187/484 (38%), Positives = 272/484 (56%), Gaps = 20/484 (4%)
Frame = +3
Query: 144 ETMELDSDKNLLKTGLVVIATLVLAKLIFSFFFKSDSKKKRLPPTLKAWP------PLIG 305
+ ME + NL +++IA L++ F LP K+ P P +G
Sbjct: 14 QAMEQVTGGNL--ASMLLIACAFTLSLVYLFRLAVGHLAPPLPTGAKSPPYIVSPIPFLG 71
Query: 306 SLLRFLKGPIVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVSAHFFKAPESDLSQQEVY- 482
+ F K PI L D Y G VF+ ++ K T+L+G E +A F + DL+ +EVY
Sbjct: 72 HAIAFGKSPIEFLEDAYEKYGPVFSFTMVGKTFTYLLGSEAAALLFNSKNEDLNAEEVYS 131
Query: 483 QFNVPTFGPGVVFDVDYTVRQEQFRFFTEALRVNKLKGYVEMMVTEAEDYFSKWGESGEV 662
+ P FG GV +DV TV EQ + L + + +V ++ E ++YF WGESGE
Sbjct: 132 RLTTPVFGKGVAYDVPNTVFLEQKKMLKSGLNIAHFRQHVSIIEKETKEYFKSWGESGEK 191
Query: 663 DLKTELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVLFP-YLPLPAHRR 839
+L L LIILTAS CL G+E+R QL + V+ L+ DLD G + L P +LPLP+ RR
Sbjct: 192 NLFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRR 251
Query: 840 RDRAREKLSEIFAKIIGSRKRSGKSENDMLQCFIESKYKDGRQTTESEVTGLLIAALFAG 1019
RDRA ++ IF K I R+ SG+ +D+LQ +ES YKDGR T+ EV G+LI L AG
Sbjct: 252 RDRAHREIKNIFYKAIQKRRESGEKIDDILQTLLESTYKDGRPLTDDEVAGMLIGLLLAG 311
Query: 1020 QHTSSITSTWTGAYLMKYGEYFSEALDEQRKLMEKHGDKIDHDILSEMDVLYRCIKEALR 1199
QHTSS TS W G +L + + EQ+ + ++ + +D L ++++L RCIKE LR
Sbjct: 312 QHTSSTTSAWMGFFLARDKTLQEKCFLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLR 371
Query: 1200 LHPPLIMLMRASHSDFSVTARDGKTFDIPKGHIVATSPAFANRLPHIFKNPDSYDPDRFS 1379
L PP++ +MR + + +V + IP GH V SP RL + ++PDR+
Sbjct: 372 LRPPIMTMMRLAKTPLTVAG-----YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRY- 425
Query: 1380 PGREEDKAAG-AFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELVSP-FPEIDW 1553
E+ A+G F+Y+ FG GRH C+GE FAY+QIK IWS +LR +E +L+ FP +++
Sbjct: 426 --LEDSPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNY 483
Query: 1554 NAMV 1565
M+
Sbjct: 484 TTMI 487
>sp|Q8K0C4|CP51A_MOUSE Lanosterol 14-alpha demethylase OS=Mus musculus
GN=Cyp51a1 PE=2 SV=1
Length = 503
Score = 318 bits (814), Expect = 1e-085
Identities = 182/482 (37%), Positives = 275/482 (57%), Gaps = 17/482 (3%)
Frame = +3
Query: 144 ETMELDSDKNLLKTGLV----VIATLVLAKLIFSFFFKSDSKKKRLPPTLKAWPPLIGSL 311
+ ME + NLL T L+ ++ + L +L + + K PP + + P +G
Sbjct: 16 QAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKS-PPHIYSPIPFLGHA 74
Query: 312 LRFLKGPIVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVSAHFFKAPESDLSQQEVY-QF 488
+ F K PI L + Y G VF+ ++ K T+L+G + +A F + DL+ +EVY +
Sbjct: 75 IAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEEVYGRL 134
Query: 489 NVPTFGPGVVFDVDYTVRQEQFRFFTEALRVNKLKGYVEMMVTEAEDYFSKWGESGEVDL 668
P FG GV +DV + EQ + L + K YV ++ EA++YF WGESGE ++
Sbjct: 135 TTPVFGKGVAYDVPNAIFLEQKKIIKSGLNIAHFKQYVPIIEKEAKEYFQSWGESGERNV 194
Query: 669 KTELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVLFP-YLPLPAHRRRD 845
L LIILTAS CL G+E+R QL + V+ L+ DLD G + L P +LPLP+ RRRD
Sbjct: 195 FEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFTHAAWLLPAWLPLPSFRRRD 254
Query: 846 RAREKLSEIFAKIIGSRKRSGKSENDMLQCFIESKYKDGRQTTESEVTGLLIAALFAGQH 1025
RA ++ IF K I R+ S + D+LQ ++S YKDGR T+ E++G+LI L AGQH
Sbjct: 255 RAHREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDGRPLTDEEISGMLIGLLLAGQH 314
Query: 1026 TSSITSTWTGAYLMKYGEYFSEALDEQRKLMEKHGDKIDHDILSEMDVLYRCIKEALRLH 1205
TSS TS W G +L K + EQ+ + + + +D L ++++L RCIKE LRL
Sbjct: 315 TSSTTSAWMGFFLAKDKPLQEKCYLEQKAVCGEDLPPLTYDQLKDLNLLDRCIKETLRLR 374
Query: 1206 PPLIMLMRASHSDFSVTARDGKTFDIPKGHIVATSPAFANRLPHIFKNPDSYDPDRFSPG 1385
PP++ +MR + + +V + IP GH V SP RL + ++PDR+
Sbjct: 375 PPIMTMMRMAKTPQTVAG-----YTIPPGHQVCVSPTVNQRLKDSWAERLDFNPDRY--- 426
Query: 1386 REEDKAAG-AFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELVSP-FPEIDWNA 1559
+++ A+G F+Y+ FG GRH C+GE FAY+QIK IWS +LR +E +L++ FP +++
Sbjct: 427 LQDNPASGEKFAYVPFGAGRHRCVGENFAYVQIKTIWSTMLRLYEFDLINGYFPTVNYTT 486
Query: 1560 MV 1565
M+
Sbjct: 487 MI 488
>sp|Q64654|CP51A_RAT Lanosterol 14-alpha demethylase OS=Rattus norvegicus
GN=Cyp51a1 PE=2 SV=1
Length = 503
Score = 316 bits (808), Expect = 5e-085
Identities = 181/482 (37%), Positives = 274/482 (56%), Gaps = 17/482 (3%)
Frame = +3
Query: 144 ETMELDSDKNLLKTGLV----VIATLVLAKLIFSFFFKSDSKKKRLPPTLKAWPPLIGSL 311
+ ME + NLL T L+ ++ + L +L + + K PP + + P +G
Sbjct: 16 QAMEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKS-PPYIYSPIPFLGHA 74
Query: 312 LRFLKGPIVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVSAHFFKAPESDLSQQEVY-QF 488
+ F K PI L + Y G VF+ ++ K T+L+G + +A F + DL+ +EVY +
Sbjct: 75 IAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEEVYGRL 134
Query: 489 NVPTFGPGVVFDVDYTVRQEQFRFFTEALRVNKLKGYVEMMVTEAEDYFSKWGESGEVDL 668
P FG GV +DV V EQ + L + K YV ++ EA++YF WGESGE ++
Sbjct: 135 TTPVFGKGVAYDVPNAVFLEQKKILKSGLNIAHFKQYVSIIEKEAKEYFKSWGESGERNV 194
Query: 669 KTELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVLFP-YLPLPAHRRRD 845
L LIILTAS CL G+E+R QL + V+ L+ DLD G + L P +LPLP+ RRRD
Sbjct: 195 FEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRD 254
Query: 846 RAREKLSEIFAKIIGSRKRSGKSENDMLQCFIESKYKDGRQTTESEVTGLLIAALFAGQH 1025
RA ++ IF K I R+ S + D+LQ ++S YKDGR T+ E+ G+LI L AGQH
Sbjct: 255 RAHREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDGRPLTDDEIAGMLIGLLLAGQH 314
Query: 1026 TSSITSTWTGAYLMKYGEYFSEALDEQRKLMEKHGDKIDHDILSEMDVLYRCIKEALRLH 1205
TSS TS W G +L + + EQ+ + + + ++ L ++++L RCIKE LRL
Sbjct: 315 TSSTTSAWMGFFLARDKPLQDKCYLEQKTVCGEDLPPLTYEQLKDLNLLDRCIKETLRLR 374
Query: 1206 PPLIMLMRASHSDFSVTARDGKTFDIPKGHIVATSPAFANRLPHIFKNPDSYDPDRFSPG 1385
PP++ +MR + + +V + IP GH V SP RL + ++PDR+
Sbjct: 375 PPIMTMMRMAKTPQTVAG-----YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRY--- 426
Query: 1386 REEDKAAG-AFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELVSP-FPEIDWNA 1559
+++ A+G F+Y+ FG GRH C+GE FAY+QIK IWS +LR +E +L++ FP +++
Sbjct: 427 LQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLINGYFPSVNYTT 486
Query: 1560 MV 1565
M+
Sbjct: 487 MI 488
>sp|Q5RE72|CP51A_PONAB Lanosterol 14-alpha demethylase OS=Pongo abelii
GN=CYP51A1 PE=2 SV=2
Length = 503
Score = 313 bits (800), Expect = 4e-084
Identities = 170/436 (38%), Positives = 258/436 (59%), Gaps = 12/436 (2%)
Frame = +3
Query: 270 PPTLKAWPPLIGSLLRFLKGPIVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVSAHFFKA 449
PP + + P +G + F K PI L + Y G VF+ ++ K T+L+G + +A F +
Sbjct: 61 PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNS 120
Query: 450 PESDLSQQEVY-QFNVPTFGPGVVFDVDYTVRQEQFRFFTEALRVNKLKGYVEMMVTEAE 626
DL+ ++VY + P FG GV +DV V EQ + L + K +V ++ E +
Sbjct: 121 KNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK 180
Query: 627 DYFSKWGESGEVDLKTELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVL 806
+YF WGESGE ++ L LIILTAS CL G+EVR QL + V+ L+ DLD G + L
Sbjct: 181 EYFESWGESGEKNVFEALSELIILTASHCLHGKEVRSQLNEKVAQLYADLDGGFSHAAWL 240
Query: 807 FP-YLPLPAHRRRDRAREKLSEIFAKIIGSRKRSGKSENDMLQCFIESKYKDGRQTTESE 983
P +LPLP+ RRRDRA ++ +IF K I R++S + +D+LQ +++ YKDGR T+ E
Sbjct: 241 LPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE 300
Query: 984 VTGLLIAALFAGQHTSSITSTWTGAYLMKYGEYFSEALDEQRKLMEKHGDKIDHDILSEM 1163
V G+LI L AGQHTSS TS W G +L + + EQ+ + ++ + +D L ++
Sbjct: 301 VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQEKCYLEQKTVCGENLPPLTYDQLKDL 360
Query: 1164 DVLYRCIKEALRLHPPLIMLMRASHSDFSVTARDGKTFDIPKGHIVATSPAFANRLPHIF 1343
++L RCIKE LRL PP++++MR + + +V + IP GH V SP RL +
Sbjct: 361 NLLDRCIKETLRLRPPIMIMMRMARTPQTVAG-----YTIPPGHQVCVSPTVNQRLKDSW 415
Query: 1344 KNPDSYDPDRFSPGREEDKAAG-AFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFEL 1520
++PDR+ +++ A+G F+Y+ FG GRH C+GE FAY+QIK IWS +LR +E
Sbjct: 416 VERLDFNPDRY---LQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF 472
Query: 1521 ELVSP-FPEIDWNAMV 1565
+L+ FP +++ M+
Sbjct: 473 DLIDGYFPTVNYTTMI 488
>sp|Q16850|CP51A_HUMAN Lanosterol 14-alpha demethylase OS=Homo sapiens
GN=CYP51A1 PE=1 SV=3
Length = 503
Score = 312 bits (799), Expect = 5e-084
Identities = 169/436 (38%), Positives = 258/436 (59%), Gaps = 12/436 (2%)
Frame = +3
Query: 270 PPTLKAWPPLIGSLLRFLKGPIVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVSAHFFKA 449
PP + + P +G + F K PI L + Y G VF+ ++ K T+L+G + +A F +
Sbjct: 61 PPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNS 120
Query: 450 PESDLSQQEVY-QFNVPTFGPGVVFDVDYTVRQEQFRFFTEALRVNKLKGYVEMMVTEAE 626
DL+ ++VY + P FG GV +DV V EQ + L + K +V ++ E +
Sbjct: 121 KNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETK 180
Query: 627 DYFSKWGESGEVDLKTELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVL 806
+YF WGESGE ++ L LIILTAS CL G+E+R QL + V+ L+ DLD G + L
Sbjct: 181 EYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWL 240
Query: 807 FP-YLPLPAHRRRDRAREKLSEIFAKIIGSRKRSGKSENDMLQCFIESKYKDGRQTTESE 983
P +LPLP+ RRRDRA ++ +IF K I R++S + +D+LQ +++ YKDGR T+ E
Sbjct: 241 LPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDE 300
Query: 984 VTGLLIAALFAGQHTSSITSTWTGAYLMKYGEYFSEALDEQRKLMEKHGDKIDHDILSEM 1163
V G+LI L AGQHTSS TS W G +L + + EQ+ + ++ + +D L ++
Sbjct: 301 VAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDL 360
Query: 1164 DVLYRCIKEALRLHPPLIMLMRASHSDFSVTARDGKTFDIPKGHIVATSPAFANRLPHIF 1343
++L RCIKE LRL PP++++MR + + +V + IP GH V SP RL +
Sbjct: 361 NLLDRCIKETLRLRPPIMIMMRMARTPQTVAG-----YTIPPGHQVCVSPTVNQRLKDSW 415
Query: 1344 KNPDSYDPDRFSPGREEDKAAG-AFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFEL 1520
++PDR+ +++ A+G F+Y+ FG GRH C+GE FAY+QIK IWS +LR +E
Sbjct: 416 VERLDFNPDRY---LQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF 472
Query: 1521 ELVSP-FPEIDWNAMV 1565
+L+ FP +++ M+
Sbjct: 473 DLIDGYFPTVNYTTMI 488
>sp|Q4R8S6|CP51A_MACFA Lanosterol 14-alpha demethylase OS=Macaca fascicularis
GN=CYP51A1 PE=2 SV=2
Length = 503
Score = 312 bits (799), Expect = 5e-084
Identities = 177/483 (36%), Positives = 276/483 (57%), Gaps = 19/483 (3%)
Frame = +3
Query: 144 ETMELDSDKNLLKTGLVVIATLVLAKLIFSFFFKSDSKKK-----RLPPTLKAWPPLIGS 308
+ ME + NLL +++IA L++ F + + + PP + + P +G
Sbjct: 16 QAMEKVTGGNLL--SMLLIACAFTLSLVYLFRLAAGHLVQLPAGAKSPPYIFSPIPFLGH 73
Query: 309 LLRFLKGPIVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVSAHFFKAPESDLSQQEVY-Q 485
+ F K P+ L + Y G VF+ ++ K T+L+G + +A F + DL+ ++VY +
Sbjct: 74 AIAFGKSPVEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSR 133
Query: 486 FNVPTFGPGVVFDVDYTVRQEQFRFFTEALRVNKLKGYVEMMVTEAEDYFSKWGESGEVD 665
P FG GV +DV V EQ + L + K +V ++ E ++YF WGESGE +
Sbjct: 134 LTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFQSWGESGEKN 193
Query: 666 LKTELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVLFP-YLPLPAHRRR 842
+ L LIILTAS CL G+E+R QL + V+ L+ DLD G + L P +LPLP+ RRR
Sbjct: 194 VFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRR 253
Query: 843 DRAREKLSEIFAKIIGSRKRSGKSENDMLQCFIESKYKDGRQTTESEVTGLLIAALFAGQ 1022
DRA ++ IF K I R++S + +D+LQ +++ YKDGR T+ EV G+LI L AGQ
Sbjct: 254 DRAHREIKNIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQ 313
Query: 1023 HTSSITSTWTGAYLMKYGEYFSEALDEQRKLMEKHGDKIDHDILSEMDVLYRCIKEALRL 1202
HTSS TS W G +L + + EQ+ + ++ + +D L ++++L RCIKE LRL
Sbjct: 314 HTSSTTSAWMGFFLARDKTLQEKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRL 373
Query: 1203 HPPLIMLMRASHSDFSVTARDGKTFDIPKGHIVATSPAFANRLPHIFKNPDSYDPDRFSP 1382
PP++++MR + + +V + IP GH V SP RL + ++PDR+
Sbjct: 374 RPPIMIMMRMARTPQTVAG-----YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRY-- 426
Query: 1383 GREEDKAAG-AFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELVSP-FPEIDWN 1556
+++ A+G F+Y+ FG GRH C+GE FAY+QIK IWS +LR +E +L+ FP +++
Sbjct: 427 -LQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYT 485
Query: 1557 AMV 1565
M+
Sbjct: 486 TMI 488
>sp|O46420|CP51A_PIG Lanosterol 14-alpha demethylase OS=Sus scrofa GN=CYP51A1
PE=2 SV=1
Length = 503
Score = 312 bits (799), Expect = 5e-084
Identities = 184/485 (37%), Positives = 275/485 (56%), Gaps = 23/485 (4%)
Frame = +3
Query: 144 ETMELDSDKNLLKTGLVVIA-TLVLAKLIFSFFFKSDSKKKRLPPTLKAWP------PLI 302
+ ME + NLL + L+ A TL+L L F ++ LP K+ P P +
Sbjct: 16 QAMEQVTGVNLLSSLLLACAFTLILVYL----FRQAIGHLAPLPAGAKSPPYIFSPIPFL 71
Query: 303 GSLLRFLKGPIVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVSAHFFKAPESDLSQQEVY 482
G + F K PI L + Y G VF+ ++ K T+L+G + +A F + DL+ ++VY
Sbjct: 72 GHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVY 131
Query: 483 -QFNVPTFGPGVVFDVDYTVRQEQFRFFTEALRVNKLKGYVEMMVTEAEDYFSKWGESGE 659
+ P FG GV +DV V EQ + L + + +V ++ E ++YF WGESGE
Sbjct: 132 SRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFRQHVSIIEKETKEYFQSWGESGE 191
Query: 660 VDLKTELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVLFP-YLPLPAHR 836
+L L LIILTAS CL G+E+R QL + V+ L+ DLD G + L P +LPLP+ R
Sbjct: 192 RNLFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFR 251
Query: 837 RRDRAREKLSEIFAKIIGSRKRSGKSENDMLQCFIESKYKDGRQTTESEVTGLLIAALFA 1016
RRDRA ++ IF K I R++S + +D+LQ ++S YKDGR T+ EV G+LI L A
Sbjct: 252 RRDRAHREIKNIFYKAIQKRRQSEEKIDDILQTLLDSTYKDGRPLTDDEVAGMLIGLLLA 311
Query: 1017 GQHTSSITSTWTGAYLMKYGEYFSEALDEQRKLMEKHGDKIDHDILSEMDVLYRCIKEAL 1196
GQHTSS TS W G +L + + EQ+ + + + +D L ++++L RCIKE L
Sbjct: 312 GQHTSSTTSAWMGFFLARDKTLQEKCYLEQKTVCGEDLPPLTYDQLKDLNLLDRCIKETL 371
Query: 1197 RLHPPLIMLMRASHSDFSVTARDGKTFDIPKGHIVATSPAFANRLPHIFKNPDSYDPDRF 1376
RL PP++ +MR + + +V + IP GH V SP RL + ++PDR+
Sbjct: 372 RLRPPIMTMMRMAKTPQTVAG-----YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRY 426
Query: 1377 SPGREEDKAAG-AFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELVSP-FPEID 1550
+++ A+G F+Y+ FG GRH C+GE FAY+QIK IWS +LR +E +L+ FP ++
Sbjct: 427 ---LQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVN 483
Query: 1551 WNAMV 1565
+ M+
Sbjct: 484 YTTMI 488
>sp|P0A513|CP51_MYCBO Lanosterol 14-alpha demethylase OS=Mycobacterium bovis
GN=cyp51 PE=3 SV=1
Length = 451
Score = 278 bits (710), Expect = 1e-073
Identities = 169/444 (38%), Positives = 246/444 (55%), Gaps = 21/444 (4%)
Frame = +3
Query: 303 GSLLRFLKGPIVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVSAHFFKAPESDLSQQEVY 482
G L F PI +++ G V T L K++ L G + FF+A + DL Q + Y
Sbjct: 17 GHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAY 76
Query: 483 QFNVPTFGPGVVFDVDYTVRQEQFRFFTEALRVNKLKGYVEMMVTEAEDYFSKWGESGEV 662
F P FG GVVFD R+E ALR ++KG+ + + + WGE+GE+
Sbjct: 77 PFMTPIFGEGVVFDASPERRKEMLH--NAALRGEQMKGHAATIEDQVRRMIADWGEAGEI 134
Query: 663 DLKTELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVLFPYLPLPAHRRR 842
DL L I T+S CL+G++ RDQL + L+H+L+ G P++ + PYLP+ + RRR
Sbjct: 135 DLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLPIESFRRR 194
Query: 843 DRAREKLSEIFAKIIGSR---KRSGKSENDMLQCFIESKYKDGR-QTTESEVTGLLIAAL 1010
D AR L + A I+ R + KS+ DML I K + G + + E+TG+ I+ +
Sbjct: 195 DEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMM 254
Query: 1011 FAGQHTSSITSTWTGAYLMKYGEYFSEALDEQRKLMEKHGD--KIDHDILSEMDVLYRCI 1184
FAG HTSS T++WT LM++ + ++ +DE L E +GD + L ++ L +
Sbjct: 255 FAGHHTSSGTASWTLIELMRHRDAYAAVIDE---LDELYGDGRSVSFHALRQIPQLENVL 311
Query: 1185 KEALRLHPPLIMLMRASHSDFSVTARDGKTFDIPKGHIVATSPAFANRLPHIFKNPDSYD 1364
KE LRLHPPLI+LMR + +F V I +G +VA SPA +NR+P F +P +
Sbjct: 312 KETLRLHPPLIILMRVAKGEFEVQGH-----RIHEGDLVAASPAISNRIPEDFPDPHDFV 366
Query: 1365 PDRFSPGREEDKAAGAFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELVSPFPE 1544
P R+ R+ED +++I FG GRH C+G FA +QIKAI+S LLR +E E+ P PE
Sbjct: 367 PARYEQPRQED-LLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQP-PE 424
Query: 1545 I---DWNAMVVGVKGSVMVRYKRR 1607
D + MVV + VRY+RR
Sbjct: 425 SYRNDHSKMVVQLAQPACVRYRRR 448
>sp|P0A512|CP51_MYCTU Lanosterol 14-alpha demethylase OS=Mycobacterium
tuberculosis GN=cyp51 PE=1 SV=1
Length = 451
Score = 278 bits (710), Expect = 1e-073
Identities = 169/444 (38%), Positives = 246/444 (55%), Gaps = 21/444 (4%)
Frame = +3
Query: 303 GSLLRFLKGPIVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVSAHFFKAPESDLSQQEVY 482
G L F PI +++ G V T L K++ L G + FF+A + DL Q + Y
Sbjct: 17 GHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAY 76
Query: 483 QFNVPTFGPGVVFDVDYTVRQEQFRFFTEALRVNKLKGYVEMMVTEAEDYFSKWGESGEV 662
F P FG GVVFD R+E ALR ++KG+ + + + WGE+GE+
Sbjct: 77 PFMTPIFGEGVVFDASPERRKEMLH--NAALRGEQMKGHAATIEDQVRRMIADWGEAGEI 134
Query: 663 DLKTELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVLFPYLPLPAHRRR 842
DL L I T+S CL+G++ RDQL + L+H+L+ G P++ + PYLP+ + RRR
Sbjct: 135 DLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLPIESFRRR 194
Query: 843 DRAREKLSEIFAKIIGSR---KRSGKSENDMLQCFIESKYKDGR-QTTESEVTGLLIAAL 1010
D AR L + A I+ R + KS+ DML I K + G + + E+TG+ I+ +
Sbjct: 195 DEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMM 254
Query: 1011 FAGQHTSSITSTWTGAYLMKYGEYFSEALDEQRKLMEKHGD--KIDHDILSEMDVLYRCI 1184
FAG HTSS T++WT LM++ + ++ +DE L E +GD + L ++ L +
Sbjct: 255 FAGHHTSSGTASWTLIELMRHRDAYAAVIDE---LDELYGDGRSVSFHALRQIPQLENVL 311
Query: 1185 KEALRLHPPLIMLMRASHSDFSVTARDGKTFDIPKGHIVATSPAFANRLPHIFKNPDSYD 1364
KE LRLHPPLI+LMR + +F V I +G +VA SPA +NR+P F +P +
Sbjct: 312 KETLRLHPPLIILMRVAKGEFEVQGH-----RIHEGDLVAASPAISNRIPEDFPDPHDFV 366
Query: 1365 PDRFSPGREEDKAAGAFSYISFGGGRHGCLGEPFAYLQIKAIWSHLLRNFELELVSPFPE 1544
P R+ R+ED +++I FG GRH C+G FA +QIKAI+S LLR +E E+ P PE
Sbjct: 367 PARYEQPRQED-LLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQP-PE 424
Query: 1545 I---DWNAMVVGVKGSVMVRYKRR 1607
D + MVV + VRY+RR
Sbjct: 425 SYRNDHSKMVVQLAQPACVRYRRR 448
>sp|P50859|CP51_CANGA Lanosterol 14-alpha demethylase OS=Candida glabrata
GN=ERG11 PE=3 SV=1
Length = 533
Score = 231 bits (588), Expect = 2e-059
Identities = 150/480 (31%), Positives = 229/480 (47%), Gaps = 31/480 (6%)
Frame = +3
Query: 252 SKKKRLPPTLKAWPPLIGSLLRFLKGPIVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVS 431
S +K PP + W P +GS + + P D G +F+ LL + MT +GP+
Sbjct: 51 SLRKDRPPLVFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKGH 110
Query: 432 AHFFKAPESDLSQQEVY-QFNVPTFGPGVVFDVDYTVRQEQFRFFTEALRVNKLKGYVEM 608
F A +D+S + Y P FG GV++D EQ +F AL YV +
Sbjct: 111 EFIFNAKLADVSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVPL 170
Query: 609 MVTEAEDYFS-------KWGESGEVDLKTELERLIILTASRCLLGREVRDQLFDDVSALF 767
+ E YF SG VD+ + I TASR LLG+E+RD+L D + L+
Sbjct: 171 IAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGKEMRDKLDTDFAYLY 230
Query: 768 HDLDNGMLPISVLFPYLPLPAHRRRDRAREKLSEIFAKIIGSRKRSGKSENDML--QCFI 941
DLD G PI+ +FP LPL +R+RD A++ +S + +I R+ +N L +
Sbjct: 231 SDLDKGFTPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKERREKNDIQNRDLIDELMK 290
Query: 942 ESKYKDGRQTTESEVTGLLIAALFAGQHTSSITSTWTGAYLMKYGEYFSEALDEQRKLME 1121
S YKDG + T+ E+ LLI L GQHTS+ TS W +L + + E EQ +++
Sbjct: 291 NSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLN 350
Query: 1122 KHGDKIDHDILSEMDVLYRCIKEALRLHPPLIMLMRASHSDFSVTARDGKTFDIPKGHIV 1301
++ +D L M +L + IKE LRLH PL L R D ++ ++ +P+ + V
Sbjct: 351 NDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAI---PNTSYVVPRDYHV 407
Query: 1302 ATSPAFANRLPHIFKNPDSYDPDRF---------SPGREEDKAAGAFS------YISFGG 1436
SP + + F P+ ++ R+ + G E D GA S Y+ FGG
Sbjct: 408 LVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGG 467
Query: 1437 GRHGCLGEPFAYLQIKAIWSHLLRNFELELVS---PFPEIDWNAMVVGVKGSVMVRYKRR 1607
GRH C+GE FAY Q+ + S +R + + P D+ +MV + +++R
Sbjct: 468 GRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVPPSDFTSMVTLPTAPAKIYWEKR 527
>sp|Q9UVC3|CP51_CUNEL Lanosterol 14-alpha demethylase OS=Cunninghamella elegans
GN=CYP51 PE=3 SV=1
Length = 512
Score = 230 bits (586), Expect = 3e-059
Identities = 127/377 (33%), Positives = 210/377 (55%), Gaps = 5/377 (1%)
Frame = +3
Query: 255 KKKRLPPTLKAWPPLIGSLLRFLKGPIVMLRDEYPNLGSVFTVNLLHKKMTFLIGPEVSA 434
K PP + + P++G+ ++F P+ L++ G VFT ++ K++T +G + +
Sbjct: 41 KNPNEPPNVFSLIPVLGNAVQFGMNPVAFLQECQKKYGDVFTFTMVGKRVTVCLGADGNQ 100
Query: 435 HFFKAPESDLSQQEVYQFNVP-TFGPGVVFDVDYTVRQEQFRFFTEALRVNKLKGYVEMM 611
F + ++ S E Y FGP VV+D + V EQ +F L + + +V M+
Sbjct: 101 FVFNSKQNLSSAAEAYNHMTKYVFGPDVVYDAPHAVFMEQKKFIKAGLNSDCFRQHVPMI 160
Query: 612 VTEAEDYFSKWGE-SGEVDLKTELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGM 788
V E E++F K+ + +G ++ LII TASRCL+G+E+R L +V+ L++DLD G
Sbjct: 161 VQETEEFFKKFNKPTGFIEAYETFGSLIIYTASRCLMGKEIRASLDGNVAKLYYDLDQGF 220
Query: 789 LPISVLFPYLPLPAHRRRDRAREKLSEIFAKIIGSRKRSGKSEN-DMLQCFIESKYKDGR 965
PI+ +FP LPLP++RRRD A +K++++++ II RK + N D+LQ +++ YKDG
Sbjct: 221 KPINFIFPNLPLPSYRRRDVACKKMADLYSSIIQRRKDEKDNNNADLLQALMDATYKDGT 280
Query: 966 QTTESEVTGLLIAALFAGQHTSSITSTWTGAYLMKYGEYFSEALDEQRKLMEKHGDKIDH 1145
+ + G++IA LF GQHTS+ TS WT L + +EQ + + +
Sbjct: 281 HIPDHHIAGMMIAVLFGGQHTSATTSAWTILELANRPDIIKALREEQIEKLGSLKADLTF 340
Query: 1146 DILSEMDVLYRCIKEALRLHPPLIMLMRASHSDFSVTARDGKTFDIPKGHIVATSPAFAN 1325
D L ++ +L I+E LRLHPP+ +MR +D V ++G +IPKG+ + +P
Sbjct: 341 DNLKDLPLLEAAIRETLRLHPPIFQMMRRVVADKIVYEKNG--MEIPKGNFICAAPGVTQ 398
Query: 1326 RLPHIFKNPDSYDPDRF 1376
P F P +Y+P R+
Sbjct: 399 VDPTYFNEPTTYNPYRW 415
>sp|Q09736|CP51_SCHPO Lanosterol 14-alpha demethylase erg11
OS=Schizosaccharomyces pombe GN=erg11 PE=1 SV=1
Length = 495
Score = 211 bits (535), Expect = 2e-053
Identities = 130/416 (31%), Positives = 207/416 (49%), Gaps = 11/416 (2%)
Frame = +3
Query: 195 VIATLVLAKLIFSFFFKSDSKKKRLPPTLKAWPPLIGSLLRFLKGPIVMLRDEYPNLGSV 374
++ ++ LA + + S+ + PP + W P +GS + + P V R+ G V
Sbjct: 8 ILLSIALAWYVGYIINQLTSRNSKRPPIVFHWIPFVGSAVAYGMDPYVFFRECRAKYGDV 67
Query: 375 FTVNLLHKKMTFLIGPEVSAHFFKAPESDLSQQEVY-QFNVPTFGPGVVFDVDYTVRQEQ 551
FT + +KMT +G + + F +DL+ +E Y P FG VV+D+ V E
Sbjct: 68 FTFVCMGRKMTAFLGVQGNDFLFNGKLADLNAEEAYSHLTTPVFGKDVVYDIPNHVFMEH 127
Query: 552 FRFFTEALRVNKLKGYVEMMVTEAEDYFSKW-----GESGEVDLKTELERLIILTASRCL 716
+F L ++ + YV +++ E + + S G+ G DL + + I TASR L
Sbjct: 128 KKFIKSGLGFSQFRSYVPLILNEMDAFLSTSPDFGPGKEGVADLLKTMPVMTIYTASRTL 187
Query: 717 LGREVRDQLFDDVSALFHDLDNGMLPISVLFPYLPLPAHRRRDRAREKLSEIFAKIIGSR 896
G EVR + L+HDLD G P++ +FP+LPLP +RRRDRA + + + + KII R
Sbjct: 188 QGAEVRKGFDAGFADLYHDLDQGFSPVNFVFPWLPLPRNRRRDRAHKIMQKTYLKIIKDR 247
Query: 897 KRSGKSE-NDMLQCFIESKYKDGRQTTESEVTGLLIAALFAGQHTSSITSTWTGAYLMKY 1073
+ S ++ DM+ + KY+DGR E E+ G++IA L AGQHTS+ T W A L
Sbjct: 248 RSSTENPGTDMIWTLMSCKYRDGRPLKEHEIAGMMIALLMAGQHTSAATIVWVLALLGSK 307
Query: 1074 GEYFSEALDEQRKLMEKHGDKIDHDILSEMDVLYRCIKEALRLHPPLIMLMRASHSDFSV 1253
E +EQ++++ ++ + + D +M +L I+E LRLHPP+ MR D V
Sbjct: 308 PEIIEMLWEEQKRVVGENLE-LKFDQYKDMPLLNYVIQETLRLHPPIHSHMRKVKRDLPV 366
Query: 1254 TARDGKTFDIPKGHIVATSPAFANRLPHIFKNPDSYDPDRFSPGREEDKAAGAFSY 1421
G IP + + +P F + +DP R++ ED+ A Y
Sbjct: 367 ---PGSKIVIPANNYLLAAPGLTATEEEYFTHATDFDPKRWNDRVNEDENAEQIDY 419
>sp|P10614|CP51_YEAST Lanosterol 14-alpha demethylase OS=Saccharomyces
cerevisiae GN=ERG11 PE=1 SV=1
Length = 530
Score = 153 bits (384), Expect = 7e-036
Identities = 90/266 (33%), Positives = 143/266 (53%), Gaps = 13/266 (4%)
Frame = +3
Query: 651 SGEVDLKTELERLIILTASRCLLGREVRDQLFDDVSALFHDLDNGMLPISVLFPYLPLPA 830
+G +D+ + I TASR LLG+E+R +L D + L+ DLD G PI+ +FP LPL
Sbjct: 191 TGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEH 250
Query: 831 HRRRDRAREKLSEIFAKIIGSRKRSGK-SENDMLQCFIE-SKYKDGRQTTESEVTGLLIA 1004
+R+RD A++ +S + +I R+++ + D++ ++ S YKDG + T+ E+ LLI
Sbjct: 251 YRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIG 310
Query: 1005 ALFAGQHTSSITSTWTGAYLMKYGEYFSEALDEQRKLMEKHGDKIDHDILSEMDVLYRCI 1184
L GQHTS+ TS W +L + + E +EQ ++++ ++ +D+L EM +L + I
Sbjct: 311 VLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTI 370
Query: 1185 KEALRLHPPLIMLMRASHSDFSVTARDGKTFDIPKGHIVATSPAFANRLPHIFKNPDSYD 1364
KE LR+H PL L R D V ++ IP G+ V SP + + F N ++
Sbjct: 371 KETLRMHHPLHSLFRKVMKDMHV---PNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFN 427
Query: 1365 PDR--------FSPGREEDKAAGAFS 1418
R +S G E D GA S
Sbjct: 428 IHRWNKDSASSYSVGEEVDYGFGAIS 453
>sp|Q759W0|CP51_ASHGO Lanosterol 14-alpha demethylase OS=Ashbya gossypii
GN=ERG11 PE=3 SV=1
Length = 529
Score = 152 bits (383), Expect = 9e-036
Identities = 96/297 (32%), Positives = 151/297 (50%), Gaps = 15/297 (5%)
Frame = +3
Query: 564 TEALR--VNKLKGYVEMMVTEAEDYFSKWGESGEVDLKTELERLIILTASRCLLGREVRD 737
TEA R V + V + ++ + SG V++ + I TASR LLG E+
Sbjct: 158 TEAFRRYVPMVMDEVRKYLRTSKHFMMNERSSGVVNVMETQPEMTIFTASRSLLGAEMHS 217
Query: 738 QLFDDVSALFHDLDNGMLPISVLFPYLPLPAHRRRDRAREKLSEIFAKIIGSRKRSGK-S 914
L D + L+ DLD G P++ +F LPL +RRRD A+ +S + K+I R+++
Sbjct: 218 MLDADFAYLYADLDKGFTPLNFVFRDLPLDNYRRRDNAQRTISSTYMKVIERRRKNNDVQ 277
Query: 915 ENDMLQCFIES-KYKDGRQTTESEVTGLLIAALFAGQHTSSITSTWTGAYLMKYGEYFSE 1091
+ D++ + S +YKDG + T+ ++ LLI L GQHTS+ TS W +L + + E
Sbjct: 278 DRDLIDALMTSAQYKDGVKMTDQQIANLLIGVLMGGQHTSAATSAWVLLHLAERPDIQEE 337
Query: 1092 ALDEQRKLMEKHGDKIDHDILSEMDVLYRCIKEALRLHPPLIMLMRASHSDFSVTARDGK 1271
+EQ ++++ ++ +++L EM +L + IKE LR+H PL L R D V
Sbjct: 338 LYEEQMRVLDGGAKELTYELLQEMPLLNQVIKETLRMHHPLHSLFRKVTRDMPV---PNT 394
Query: 1272 TFDIPKGHIVATSPAFANRLPHIFKNPDSYDPDRF--------SPGREEDKAAGAFS 1418
++ IPK H V SP F + F N ++P R+ S G + D GA S
Sbjct: 395 SYVIPKDHYVLASPGFCHLSEEYFPNAKEFNPHRWDNDAASSVSTGEKVDYGFGAIS 451
>sp|P49602|CP51_USTMA Lanosterol 14-alpha demethylase OS=Ustilago maydis
GN=ERG11 PE=3 SV=1
Length = 561
Score = 84 bits (205), Expect = 4e-015
Identities = 46/123 (37%), Positives = 77/123 (62%), Gaps = 4/123 (3%)
Frame = +3
Query: 546 EQFRFFTEALRVNKLKGYVEMMVTEAEDYFSKWGESGEVDLKTELERLIILTASRCLLGR 725
E FR + + V++++ Y++ ++A K ++ VD+ + LIILTASR L G+
Sbjct: 165 ENFRVYVPQI-VDEVREYIK---SDARFSALKTRKTITVDIFQAMSELIILTASRTLQGK 220
Query: 726 EVRDQLFDDVSALFHDLDNGMLPISVLFPYLPLPAHRRRDRAREKLSEIFAKIIGSRKRS 905
EVR L + L+HDLD+G PI+ + P LPLP++ +RDRA++K+S+ + I+ R+ +
Sbjct: 221 EVRQGLDKSFAQLYHDLDSGFTPINFVIPNLPLPSNFKRDRAQKKMSQFYQDIVAKRRAA 280
Query: 906 GKS 914
G S
Sbjct: 281 GAS 283
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,436,365,428
Number of Sequences: 518415
Number of Extensions: 75436365428
Number of Successful Extensions: 513409628
Number of sequences better than 0.0: 0
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