BLASTX 7.6.2
Query= UN18339 /QuerySize=1475
(1474 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8NBU5|ATAD1_HUMAN ATPase family AAA domain-containing protei... 276 3e-073
sp|Q9D5T0|ATAD1_MOUSE ATPase family AAA domain-containing protei... 276 3e-073
sp|Q505J9|ATAD1_RAT ATPase family AAA domain-containing protein ... 276 3e-073
sp|Q503W7|ATD1B_DANRE ATPase family AAA domain-containing protei... 274 1e-072
sp|Q7ZZ25|ATD1A_DANRE ATPase family AAA domain-containing protei... 273 3e-072
sp|P28737|MSP1_YEAST Protein MSP1 OS=Saccharomyces cerevisiae GN... 252 9e-066
sp|B7PXE3|SPAST_IXOSC Spastin OS=Ixodes scapularis GN=spas PE=3 ... 222 6e-057
sp|Q6AZT2|SPAST_XENLA Spastin OS=Xenopus laevis GN=spast PE=2 SV=1 213 3e-054
sp|Q05AS3|SPAST_XENTR Spastin OS=Xenopus tropicalis GN=spast PE=... 213 3e-054
sp|Q719N1|SPAST_PIG Spastin (Fragment) OS=Sus scrofa GN=SPAST PE... 213 4e-054
sp|Q6NW58|SPAST_DANRE Spastin OS=Danio rerio GN=spast PE=2 SV=2 212 6e-054
sp|A2VDN5|SPAST_BOVIN Spastin OS=Bos taurus GN=SPAST PE=2 SV=1 211 1e-053
sp|Q5ZK92|SPAST_CHICK Spastin OS=Gallus gallus GN=SPAST PE=2 SV=1 211 1e-053
sp|Q9QYY8|SPAST_MOUSE Spastin OS=Mus musculus GN=Spast PE=2 SV=3 211 1e-053
sp|B2RYN7|SPAST_RAT Spastin OS=Rattus norvegicus GN=Spast PE=2 SV=1 211 1e-053
sp|Q9UBP0|SPAST_HUMAN Spastin OS=Homo sapiens GN=SPAST PE=1 SV=1 210 2e-053
sp|Q60QD1|FIGL1_CAEBR Fidgetin-like protein 1 OS=Caenorhabditis ... 210 4e-053
sp|O16299|FIGL1_CAEEL Fidgetin-like protein 1 OS=Caenorhabditis ... 204 2e-051
sp|Q8MNV0|SPAST_CAEEL Probable spastin homolog spas-1 OS=Caenorh... 203 3e-051
sp|A8XV40|SPAST_CAEBR Probable spastin homolog spas-1 OS=Caenorh... 201 1e-050
>sp|Q8NBU5|ATAD1_HUMAN ATPase family AAA domain-containing protein 1 OS=Homo
sapiens GN=ATAD1 PE=1 SV=1
Length = 361
Score = 276 bits (705), Expect = 3e-073
Identities = 143/310 (46%), Positives = 204/310 (65%), Gaps = 1/310 (0%)
Frame = -3
Query: 1274 LDPNREASKKALEHKKEISKRLGRPLIHTTPYEDVIARDVINPDHIDVEFGSIGGLETIK 1095
+DP R+ +A + +++ K++G + + YE IA +++P ++ V + I GL+ +
Sbjct: 41 IDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVI 100
Query: 1094 EALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIAKESGAVFINVRVS 915
L + VILP K+ LF +LL P KGVLLYGPPG GKT++AKA AKE+G FIN++ S
Sbjct: 101 TDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPS 160
Query: 914 NLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHEAMANMKTEFMALW 735
L KW+G++QKL AAVFSLA KLQP+IIFIDE+DSFL R S+DHEA A MK +FM+LW
Sbjct: 161 TLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLW 220
Query: 734 DGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAEILKVTLKGERVEP 555
DG TD + +V+V+ ATNRP +LD AI+RR+P F I P K+R ILK+ LK E V+
Sbjct: 221 DGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREAILKLILKNENVDR 280
Query: 554 DIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEE-ERKGRPCPVPRPLSQLDLEKVL 378
+D VA+ +G++GSD+ E+C+ AA +RE + + RP+ Q DL + +
Sbjct: 281 HVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDEDEIRPVQQQDLHRAI 340
Query: 377 ATSKKTQVAA 348
KK++ AA
Sbjct: 341 EKMKKSKDAA 350
>sp|Q9D5T0|ATAD1_MOUSE ATPase family AAA domain-containing protein 1 OS=Mus
musculus GN=Atad1 PE=1 SV=1
Length = 361
Score = 276 bits (705), Expect = 3e-073
Identities = 143/310 (46%), Positives = 204/310 (65%), Gaps = 1/310 (0%)
Frame = -3
Query: 1274 LDPNREASKKALEHKKEISKRLGRPLIHTTPYEDVIARDVINPDHIDVEFGSIGGLETIK 1095
+DP R+ +A + +++ K++G + + YE IA +++P ++ V + I GL+ +
Sbjct: 41 IDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVI 100
Query: 1094 EALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIAKESGAVFINVRVS 915
L + VILP K+ LF +LL P KGVLLYGPPG GKT++AKA AKE+G FIN++ S
Sbjct: 101 TDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPS 160
Query: 914 NLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHEAMANMKTEFMALW 735
L KW+G++QKL AAVFSLA KLQP+IIFIDE+DSFL R S+DHEA A MK +FM+LW
Sbjct: 161 TLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLW 220
Query: 734 DGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAEILKVTLKGERVEP 555
DG TD + +V+V+ ATNRP +LD AI+RR+P F I P K+R ILK+ LK E V+
Sbjct: 221 DGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREAILKLILKNENVDR 280
Query: 554 DIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEE-ERKGRPCPVPRPLSQLDLEKVL 378
+D VA+ +G++GSD+ E+C+ AA +RE + + RP+ Q DL + +
Sbjct: 281 HVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDEDEIRPVQQQDLHRAI 340
Query: 377 ATSKKTQVAA 348
KK++ AA
Sbjct: 341 EKMKKSKDAA 350
>sp|Q505J9|ATAD1_RAT ATPase family AAA domain-containing protein 1 OS=Rattus
norvegicus GN=Atad1 PE=2 SV=1
Length = 361
Score = 276 bits (705), Expect = 3e-073
Identities = 143/310 (46%), Positives = 204/310 (65%), Gaps = 1/310 (0%)
Frame = -3
Query: 1274 LDPNREASKKALEHKKEISKRLGRPLIHTTPYEDVIARDVINPDHIDVEFGSIGGLETIK 1095
+DP R+ +A + +++ K++G + + YE IA +++P ++ V + I GL+ +
Sbjct: 41 IDPTRKQKVEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDPLNMHVTWSDIAGLDDVI 100
Query: 1094 EALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIAKESGAVFINVRVS 915
L + VILP K+ LF +LL P KGVLLYGPPG GKT++AKA AKE+G FIN++ S
Sbjct: 101 TDLKDTVILPIKKKHLFENSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGCRFINLQPS 160
Query: 914 NLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHEAMANMKTEFMALW 735
L KW+G++QKL AAVFSLA KLQP+IIFIDE+DSFL R S+DHEA A MK +FM+LW
Sbjct: 161 TLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLW 220
Query: 734 DGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAEILKVTLKGERVEP 555
DG TD + +V+V+ ATNRP +LD AI+RR+P F I P K+R ILK+ LK E V+
Sbjct: 221 DGLDTDHSCQVIVMGATNRPQDLDSAIMRRMPTRFHINQPALKQREAILKLILKNENVDR 280
Query: 554 DIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEE-ERKGRPCPVPRPLSQLDLEKVL 378
+D VA+ +G++GSD+ E+C+ AA +RE + + RP+ Q DL + +
Sbjct: 281 HVDLLEVAQETDGFSGSDLKEMCRDAALLCVREYVNSTSEESHDEDEIRPVQQQDLHRAI 340
Query: 377 ATSKKTQVAA 348
KK++ AA
Sbjct: 341 EKMKKSKDAA 350
>sp|Q503W7|ATD1B_DANRE ATPase family AAA domain-containing protein 1-B OS=Danio
rerio GN=atad1b PE=2 SV=2
Length = 362
Score = 274 bits (700), Expect = 1e-072
Identities = 137/308 (44%), Positives = 206/308 (66%), Gaps = 2/308 (0%)
Frame = -3
Query: 1274 LDPNREASKKALEHKKEISKRLGRPLIHTTPYEDVIARDVINPDHIDVEFGSIGGLETIK 1095
+DP R+ +A + +++ +++G + + YE IA +++P + + + I GL+ +
Sbjct: 45 IDPTRKQKVEAQKQAEKLMRQIGVQNVKLSEYEMSIAAHLVDPLTMQITWHDIAGLDEVI 104
Query: 1094 EALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIAKESGAVFINVRVS 915
L + VILP ++ LF +LL P KGVLLYGPPG GKT++AKA AKE+G FIN++ S
Sbjct: 105 TELKDTVILPIQKRHLFEGSRLLQPPKGVLLYGPPGCGKTLIAKATAKEAGFRFINLQPS 164
Query: 914 NLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHEAMANMKTEFMALW 735
L KW+G++QKL AAVFSLA KLQP+IIFIDE+DSFL R S+DHEA A MK +FM+LW
Sbjct: 165 TLTDKWYGESQKLAAAVFSLAIKLQPSIIFIDEIDSFLRNRSSSDHEATAMMKAQFMSLW 224
Query: 734 DGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAEILKVTLKGERVEP 555
DG TD N +V+++ ATNRP +LD AILRR+P F I P+ ++R +ILK+ L+ E VE
Sbjct: 225 DGLDTDYNCQVIIMGATNRPQDLDSAILRRMPTRFHINQPNVRQRKDILKLILENENVES 284
Query: 554 DIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEEERKGRPCPVPRPLSQLDLEKVLA 375
++ +A+ +G++GSD+ E+C+ AA +R+ + +E RP+ Q DL++ +
Sbjct: 285 AVELSEIAKQTDGFSGSDLREMCRDAALLCVRDFVHQESPEE--DFIRPIRQEDLQRAIE 342
Query: 374 TSKKTQVA 351
KK++ A
Sbjct: 343 KMKKSKSA 350
>sp|Q7ZZ25|ATD1A_DANRE ATPase family AAA domain-containing protein 1-A OS=Danio
rerio GN=atad1a PE=2 SV=2
Length = 380
Score = 273 bits (697), Expect = 3e-072
Identities = 134/279 (48%), Positives = 192/279 (68%)
Frame = -3
Query: 1274 LDPNREASKKALEHKKEISKRLGRPLIHTTPYEDVIARDVINPDHIDVEFGSIGGLETIK 1095
LDP ++ +A + +++ K++G + T YE IA +++P I V + + GL+ I
Sbjct: 44 LDPTQKQKSQAKKRAEQLMKQIGVEGVSLTEYEMNIATLLVDPRSIKVTWRDVAGLDEII 103
Query: 1094 EALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIAKESGAVFINVRVS 915
+ + VILP ++ LF+ KLL P KGVLLYGPPG GKT++AKA AK SG FIN++ S
Sbjct: 104 SEMQDTVILPFQKRHLFSGSKLLQPPKGVLLYGPPGCGKTLIAKATAKASGCRFINLQAS 163
Query: 914 NLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHEAMANMKTEFMALW 735
L KW+G++QKL AAVFSLA K+QP IIF+DE+DSFL R S DHEA A MK +FM+LW
Sbjct: 164 TLTDKWYGESQKLTAAVFSLAVKIQPCIIFLDEIDSFLRNRSSMDHEATAMMKAQFMSLW 223
Query: 734 DGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAEILKVTLKGERVEP 555
DG T N++VMV+ ATNRP ++D AILRR+P AF +G+P+ +R EIL++ L GE +
Sbjct: 224 DGLDTGENSQVMVMGATNRPQDVDAAILRRMPTAFHVGLPNAAQREEILRLILSGENLSN 283
Query: 554 DIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEEER 438
I+ +A EGY+GSD+ ELC+ AA + +R+ + +++
Sbjct: 284 AINLKEIASQSEGYSGSDLKELCRDAAMYRVRDYVRKQQ 322
>sp|P28737|MSP1_YEAST Protein MSP1 OS=Saccharomyces cerevisiae GN=MSP1 PE=1
SV=2
Length = 362
Score = 252 bits (641), Expect = 9e-066
Identities = 127/274 (46%), Positives = 186/274 (67%), Gaps = 3/274 (1%)
Frame = -3
Query: 1253 SKKALEHKKEISKRLGRPLIHTTPYEDVIARDVINPDHIDVEFGSIGGLETIKEALYELV 1074
+K++L+ +K + + + YE I ++ PD I++ F IGGL+ + L+E V
Sbjct: 48 AKQSLQWEKLVKRSPALAEVTLDAYERTILSSIVTPDEINITFQDIGGLDPLISDLHESV 107
Query: 1073 ILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIAKESGAVFINVRVSNLMSKWF 894
I P PE+++ LL GVLLYGPPG GKTMLAKA+AKESGA FI++R+S++M KW+
Sbjct: 108 IYPLMMPEVYSNSPLLQAPSGVLLYGPPGCGKTMLAKALAKESGANFISIRMSSIMDKWY 167
Query: 893 GDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHEAMANMKTEFMALWDGFSTDP 714
G++ K+V A+FSLA KLQP IIFIDE+DSFL +R STDHE A +K EFM LWDG
Sbjct: 168 GESNKIVDAMFSLANKLQPCIIFIDEIDSFLRERSSTDHEVTATLKAEFMTLWDGLLN-- 225
Query: 713 NARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAEILKVTLKGERVEPD-IDYDH 537
N RVM++ ATNR +++D+A LRRLP+ F + +P +R +IL V LK +++ D D
Sbjct: 226 NGRVMIIGATNRINDIDDAFLRRLPKRFLVSLPGSDQRYKILSVLLKDTKLDEDEFDLQL 285
Query: 536 VARLCEGYTGSDIFELCKKAAYFPIREILEEERK 435
+A +G++GSD+ ELC++AA +E ++++R+
Sbjct: 286 IADNTKGFSGSDLKELCREAALDAAKEYIKQKRQ 319
>sp|B7PXE3|SPAST_IXOSC Spastin OS=Ixodes scapularis GN=spas PE=3 SV=1
Length = 648
Score = 222 bits (565), Expect = 6e-057
Identities = 121/260 (46%), Positives = 167/260 (64%), Gaps = 6/260 (2%)
Frame = -3
Query: 1133 VEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIA 954
V F I G E K+AL E+VILP+ RPELF L P KG+LL+GPPG GKTMLAKA+A
Sbjct: 371 VLFSDIAGQEVAKQALSEMVILPTDRPELFT--GLRAPPKGLLLFGPPGNGKTMLAKAVA 428
Query: 953 KESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHE 774
ES + F+N+ ++L SK+ G+ +KLV A+F++A +LQP+IIFIDEVDS L +R+ +HE
Sbjct: 429 HESNSTFLNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLSERKDNEHE 488
Query: 773 AMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAE 594
A +KTEF+ +DG T RV+V+ ATNRP ELD+A LRR + + +PD R
Sbjct: 489 ATRRLKTEFLVEFDGLHTGSEERVLVMGATNRPQELDDAALRRFTKRVYVTLPDHNTRVI 548
Query: 593 ILKVTLKGERVEPDID-YDHVARLCEGYTGSDIFELCKKAAYFPIREILEEERKGRPCPV 417
+L+ LK D ++ARL EGY+GSD+ L K AA PIRE+ E+ + C
Sbjct: 549 LLEKLLKKHNNPLSADKLKYLARLTEGYSGSDLTALAKDAALGPIRELNPEQVR---CVD 605
Query: 416 PRPLSQLDLEKVLATSKKTQ 357
P+ + + L+ L + KK +
Sbjct: 606 PKKMRNISLQDFLDSLKKVR 625
>sp|Q6AZT2|SPAST_XENLA Spastin OS=Xenopus laevis GN=spast PE=2 SV=1
Length = 600
Score = 213 bits (542), Expect = 3e-054
Identities = 117/248 (47%), Positives = 161/248 (64%), Gaps = 3/248 (1%)
Frame = -3
Query: 1133 VEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIA 954
V+F I G + K+AL E+VILPS RPELF L P +G+LL+GPPG GKTMLAKA+A
Sbjct: 323 VKFADIAGQDLAKQALQEIVILPSIRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 380
Query: 953 KESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHE 774
ES A F N+ ++L SK+ G+ +KLV A+FS+A +LQP+IIFIDEVDS L +RR +H+
Sbjct: 381 AESNATFFNISAASLTSKYVGEGEKLVRALFSVARELQPSIIFIDEVDSLLCERREGEHD 440
Query: 773 AMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAE 594
A +KTEF+ +DG + + RV+V+ ATNRP ELD+A+LRR + + +P+ + R
Sbjct: 441 ASRRLKTEFLIEFDGVQSGGDDRVLVMGATNRPQELDDAVLRRFTKRVYVALPNEETRLV 500
Query: 593 ILKVTL-KGERVEPDIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEEERKGRPCPV 417
+LK L K + + ++RL EGY+GSDI L K AA PIRE+ E+ K
Sbjct: 501 LLKNLLSKQGNPLSEKELTQLSRLTEGYSGSDITALAKDAALGPIRELKPEQVKNMAASE 560
Query: 416 PRPLSQLD 393
R + D
Sbjct: 561 MRNMKYSD 568
>sp|Q05AS3|SPAST_XENTR Spastin OS=Xenopus tropicalis GN=spast PE=2 SV=1
Length = 603
Score = 213 bits (541), Expect = 3e-054
Identities = 117/249 (46%), Positives = 163/249 (65%), Gaps = 5/249 (2%)
Frame = -3
Query: 1133 VEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIA 954
V+F I G + K+AL E+VILPS RPELF L P +G+LL+GPPG GKTMLAKA+A
Sbjct: 326 VKFADIAGQDLAKQALQEIVILPSIRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 383
Query: 953 KESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHE 774
ES A F N+ ++L SK+ G+ +KLV A+FS+A +LQP+IIFIDEVDS L +RR +H+
Sbjct: 384 AESNATFFNISAASLTSKYVGEGEKLVRALFSVARELQPSIIFIDEVDSLLCERREGEHD 443
Query: 773 AMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAE 594
A +KTEF+ +DG + + RV+V+ ATNRP ELD+A+LRR + + +P+ + R
Sbjct: 444 ASRRLKTEFLIEFDGVQSGGDDRVLVMGATNRPQELDDAVLRRFTKRVYVSLPNEETRLL 503
Query: 593 ILKVTLKGERVEP--DIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEEERKGRPCP 420
+LK L ++ P + + ++RL EGY+GSDI L K AA PIRE+ E+ K
Sbjct: 504 LLK-NLLSKQGNPLNEKELTQLSRLTEGYSGSDITALAKDAALGPIRELKPEQVKNMAAS 562
Query: 419 VPRPLSQLD 393
R + D
Sbjct: 563 EMRNIKYSD 571
>sp|Q719N1|SPAST_PIG Spastin (Fragment) OS=Sus scrofa GN=SPAST PE=2 SV=2
Length = 613
Score = 213 bits (540), Expect = 4e-054
Identities = 119/259 (45%), Positives = 165/259 (63%), Gaps = 3/259 (1%)
Frame = -3
Query: 1133 VEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIA 954
V+F I G E K+AL E+VILPS RPELF L P +G+LL+GPPG GKTMLAKA+A
Sbjct: 336 VKFDDIAGQELAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 393
Query: 953 KESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHE 774
ES A F N+ ++L SK+ G+ +KLV A+F++A +LQP+IIFIDEVDS L +RR +H+
Sbjct: 394 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLRERREGEHD 453
Query: 773 AMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAE 594
A +KTEF+ +DG + + RV+V+ ATNRP ELDEA+LRR + + +P+ + R
Sbjct: 454 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLL 513
Query: 593 ILKVTL-KGERVEPDIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEEERKGRPCPV 417
+LK L K + +ARL +GY+GSD+ L K AA PIRE+ E+ K
Sbjct: 514 LLKNLLCKQGSPLTQKELAQLARLTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASE 573
Query: 416 PRPLSQLDLEKVLATSKKT 360
R + D + L K++
Sbjct: 574 MRNIRLSDFTESLKKIKRS 592
>sp|Q6NW58|SPAST_DANRE Spastin OS=Danio rerio GN=spast PE=2 SV=2
Length = 570
Score = 212 bits (539), Expect = 6e-054
Identities = 116/272 (42%), Positives = 170/272 (62%), Gaps = 4/272 (1%)
Frame = -3
Query: 1172 VIARDVINPDHIDVEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGP 993
+I ++++ + V F I G + K+AL E+VILP+ RPELF L P +G+LL+GP
Sbjct: 280 LILNEIVDSGSV-VRFDDIAGQDLAKQALQEIVILPALRPELFT--GLRAPARGLLLFGP 336
Query: 992 PGTGKTMLAKAIAKESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEV 813
PG GKTMLAKA+A ES A F N+ + L SK+ G+ +KLV A+F++A +LQP+IIFIDE+
Sbjct: 337 PGNGKTMLAKAVAMESNATFFNISAATLTSKYVGEGEKLVRALFAVARELQPSIIFIDEI 396
Query: 812 DSFLGQRRSTDHEAMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQA 633
DS L +RR +H+A +KTEF+ +DG + + RV+V+ ATNRP ELDEA+LRR +
Sbjct: 397 DSLLCERREGEHDASRRLKTEFLIEFDGVQSGGDERVLVMGATNRPQELDEAVLRRFAKR 456
Query: 632 FEIGMPDRKERAEILKVTLKGERVE-PDIDYDHVARLCEGYTGSDIFELCKKAAYFPIRE 456
+ +P + R ++LK L R + +ARL +GY+GSD+ L K AA PIRE
Sbjct: 457 IYVALPTEETRLKLLKNLLSKHRNPLSQKELSQLARLTDGYSGSDLTSLAKDAALGPIRE 516
Query: 455 ILEEERKGRPCPVPRPLSQLDLEKVLATSKKT 360
+ E+ + R + D + L K++
Sbjct: 517 LKPEQVRNMSAHEMRDIRISDFLESLKRIKRS 548
>sp|A2VDN5|SPAST_BOVIN Spastin OS=Bos taurus GN=SPAST PE=2 SV=1
Length = 614
Score = 211 bits (537), Expect = 1e-053
Identities = 118/259 (45%), Positives = 164/259 (63%), Gaps = 3/259 (1%)
Frame = -3
Query: 1133 VEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIA 954
V+F I G E K+AL E+VILPS RPELF L P +G+LL+GPPG GKTMLAKA+A
Sbjct: 337 VKFDDIAGQELAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 394
Query: 953 KESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHE 774
ES A F N+ ++L SK+ G+ +KLV A+F++A +LQP+IIFIDEVDS L +RR +H+
Sbjct: 395 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 454
Query: 773 AMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAE 594
A +KTEF+ +DG + + RV+V+ ATNRP ELDEA+LRR + + +P+ + R
Sbjct: 455 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFTKRVYVSLPNEETRLL 514
Query: 593 ILKVTL-KGERVEPDIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEEERKGRPCPV 417
+LK L K + +AR+ GY+GSD+ L K AA PIRE+ E+ K
Sbjct: 515 LLKNLLCKQGSPLTQKELAQLARMTNGYSGSDLTALAKDAALGPIRELKPEQVKNMSASE 574
Query: 416 PRPLSQLDLEKVLATSKKT 360
R + D + L K++
Sbjct: 575 MRNIRLSDFTESLKKIKRS 593
>sp|Q5ZK92|SPAST_CHICK Spastin OS=Gallus gallus GN=SPAST PE=2 SV=1
Length = 613
Score = 211 bits (537), Expect = 1e-053
Identities = 116/260 (44%), Positives = 166/260 (63%), Gaps = 5/260 (1%)
Frame = -3
Query: 1133 VEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIA 954
V+F I G E K+AL E+VILPS RPELF L P +G+LL+GPPG GKTMLAKA+A
Sbjct: 336 VKFDDIAGQELAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 393
Query: 953 KESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHE 774
ES A F N+ ++L SK+ G+ +KLV A+F++A +LQP+IIFIDEVDS L +RR +H+
Sbjct: 394 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 453
Query: 773 AMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAE 594
A +KTEF+ +DG + R++V+ ATNRP ELD+A+LRR + + +P+ + R
Sbjct: 454 ASRRLKTEFLIEFDGVQSSGEDRILVMGATNRPQELDDAVLRRFTKRVYVSLPNEETRLI 513
Query: 593 ILKVTLKGERVEP--DIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEEERKGRPCP 420
+LK L ++ P + +AR+ +GY+GSD+ L K AA PIRE+ E+ K
Sbjct: 514 LLK-NLLSKQGSPLTQKELAQLARMTDGYSGSDLTALVKDAALGPIRELKPEQVKNMSAS 572
Query: 419 VPRPLSQLDLEKVLATSKKT 360
R + D + L K++
Sbjct: 573 EMRNIKLSDFTESLKKIKRS 592
>sp|Q9QYY8|SPAST_MOUSE Spastin OS=Mus musculus GN=Spast PE=2 SV=3
Length = 614
Score = 211 bits (537), Expect = 1e-053
Identities = 118/259 (45%), Positives = 165/259 (63%), Gaps = 3/259 (1%)
Frame = -3
Query: 1133 VEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIA 954
V+F I G E K+AL E+VILPS RPELF L P +G+LL+GPPG GKTMLAKA+A
Sbjct: 337 VKFDDIAGQELAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 394
Query: 953 KESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHE 774
ES A F N+ ++L SK+ G+ +KLV A+F++A +LQP+IIFIDEVDS L +RR +H+
Sbjct: 395 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 454
Query: 773 AMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAE 594
A +KTEF+ +DG + + RV+V+ ATNRP ELDEA+LRR + + +P+ + R
Sbjct: 455 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLL 514
Query: 593 ILKVTL-KGERVEPDIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEEERKGRPCPV 417
+LK L K + +AR+ +GY+GSD+ L K AA PIRE+ E+ K
Sbjct: 515 LLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASE 574
Query: 416 PRPLSQLDLEKVLATSKKT 360
R + D + L K++
Sbjct: 575 MRNIRLSDFTESLKKIKRS 593
>sp|B2RYN7|SPAST_RAT Spastin OS=Rattus norvegicus GN=Spast PE=2 SV=1
Length = 581
Score = 211 bits (537), Expect = 1e-053
Identities = 118/259 (45%), Positives = 165/259 (63%), Gaps = 3/259 (1%)
Frame = -3
Query: 1133 VEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIA 954
V+F I G E K+AL E+VILPS RPELF L P +G+LL+GPPG GKTMLAKA+A
Sbjct: 304 VKFDDIAGQELAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 361
Query: 953 KESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHE 774
ES A F N+ ++L SK+ G+ +KLV A+F++A +LQP+IIFIDEVDS L +RR +H+
Sbjct: 362 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 421
Query: 773 AMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAE 594
A +KTEF+ +DG + + RV+V+ ATNRP ELDEA+LRR + + +P+ + R
Sbjct: 422 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLL 481
Query: 593 ILKVTL-KGERVEPDIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEEERKGRPCPV 417
+LK L K + +AR+ +GY+GSD+ L K AA PIRE+ E+ K
Sbjct: 482 LLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASE 541
Query: 416 PRPLSQLDLEKVLATSKKT 360
R + D + L K++
Sbjct: 542 MRNIRLSDFTESLKKIKRS 560
>sp|Q9UBP0|SPAST_HUMAN Spastin OS=Homo sapiens GN=SPAST PE=1 SV=1
Length = 616
Score = 210 bits (534), Expect = 2e-053
Identities = 117/259 (45%), Positives = 165/259 (63%), Gaps = 3/259 (1%)
Frame = -3
Query: 1133 VEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIA 954
V+F I G + K+AL E+VILPS RPELF L P +G+LL+GPPG GKTMLAKA+A
Sbjct: 339 VKFDDIAGQDLAKQALQEIVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVA 396
Query: 953 KESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHE 774
ES A F N+ ++L SK+ G+ +KLV A+F++A +LQP+IIFIDEVDS L +RR +H+
Sbjct: 397 AESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHD 456
Query: 773 AMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAE 594
A +KTEF+ +DG + + RV+V+ ATNRP ELDEA+LRR + + +P+ + R
Sbjct: 457 ASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLL 516
Query: 593 ILKVTL-KGERVEPDIDYDHVARLCEGYTGSDIFELCKKAAYFPIREILEEERKGRPCPV 417
+LK L K + +AR+ +GY+GSD+ L K AA PIRE+ E+ K
Sbjct: 517 LLKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASE 576
Query: 416 PRPLSQLDLEKVLATSKKT 360
R + D + L K++
Sbjct: 577 MRNIRLSDFTESLKKIKRS 595
>sp|Q60QD1|FIGL1_CAEBR Fidgetin-like protein 1 OS=Caenorhabditis briggsae
GN=figl-1 PE=3 SV=1
Length = 591
Score = 210 bits (532), Expect = 4e-053
Identities = 105/228 (46%), Positives = 154/228 (67%), Gaps = 3/228 (1%)
Frame = -3
Query: 1133 VEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAIA 954
+ + + GLE K+AL E+V+LP +RP++F L P KGVLL+GPPGTGKTM+ + +A
Sbjct: 313 IGWADVAGLEGAKKALKEIVVLPFQRPDIFT--GLRAPPKGVLLFGPPGTGKTMIGRCVA 370
Query: 953 KESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDHE 774
++ A F N+ S+L SKW G+ +KLV A+FS+A P++IFIDE+DS L R ++HE
Sbjct: 371 SQAQATFFNISASSLTSKWVGEGEKLVRALFSVARLKLPSVIFIDEIDSLLSARSESEHE 430
Query: 773 AMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERAE 594
+ +KTEF+ DG +T P+ R++VL ATNRP ELDEA RR + I +P+ R +
Sbjct: 431 SSRRIKTEFLVQLDGVNTAPDERLLVLGATNRPQELDEAARRRFQKRLYIALPEPDSRTQ 490
Query: 593 ILKVTLKGERVE-PDIDYDHVARLCEGYTGSDIFELCKKAAYFPIREI 453
I++ L+G R E D + + + RL +GY+G+D+ +LC +AA PIREI
Sbjct: 491 IVENLLRGTRHEITDHNLEKIRRLTDGYSGADMRQLCTEAAMGPIREI 538
>sp|O16299|FIGL1_CAEEL Fidgetin-like protein 1 OS=Caenorhabditis elegans
GN=figl-1 PE=1 SV=1
Length = 594
Score = 204 bits (517), Expect = 2e-051
Identities = 101/229 (44%), Positives = 153/229 (66%), Gaps = 3/229 (1%)
Frame = -3
Query: 1136 DVEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLAKAI 957
++ + + GLE K+AL E+V+LP KRP++F + P KGVLL+GPPGTGKTM+ + +
Sbjct: 312 EIGWADVAGLEGAKKALREIVVLPFKRPDVFT--GIRAPPKGVLLFGPPGTGKTMIGRCV 369
Query: 956 AKESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRSTDH 777
A + A F N+ S+L SKW G+ +KLV A+FS+A P++IFIDE+DS L R ++H
Sbjct: 370 ASQCKATFFNISASSLTSKWVGEGEKLVRALFSVARLKLPSVIFIDEIDSLLSSRSESEH 429
Query: 776 EAMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRKERA 597
E+ +KTEF+ DG +T P+ R++VL ATNRP ELDEA RR + I +P+ + R
Sbjct: 430 ESSRRIKTEFLVQLDGVNTAPDERLLVLGATNRPQELDEAARRRFQKRLYIALPEPESRT 489
Query: 596 EILKVTLKGERVE-PDIDYDHVARLCEGYTGSDIFELCKKAAYFPIREI 453
+I++ L G R + + + + + L +GY+G+D+ +LC +AA PIR+I
Sbjct: 490 QIVQNLLVGTRHDITNHNLERIRELTDGYSGADMRQLCTEAAMGPIRDI 538
>sp|Q8MNV0|SPAST_CAEEL Probable spastin homolog spas-1 OS=Caenorhabditis elegans
GN=spas-1 PE=1 SV=2
Length = 512
Score = 203 bits (515), Expect = 3e-051
Identities = 104/234 (44%), Positives = 147/234 (62%), Gaps = 5/234 (2%)
Frame = -3
Query: 1145 DHIDVEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLA 966
D+ V + G + K AL E VILP+ P LF L P KG+LL+GPPG GKT+LA
Sbjct: 232 DNTGVRMDDVAGCHSAKAALEEAVILPALNPNLFK--GLRQPVKGILLFGPPGNGKTLLA 289
Query: 965 KAIAKESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRS 786
KA+A ES +F N+ S+L SKW GD++K + +F +A QP+IIFIDE+DS L +R
Sbjct: 290 KAVAGESKQMFFNISASSLTSKWVGDSEKTIRGLFQIARNAQPSIIFIDEIDSILCERSE 349
Query: 785 TDHEAMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRK 606
D E MKTEF+ +DG ++ + R++V+ ATNRP ELD+A+LRR P+ + +PD +
Sbjct: 350 KDAEVSRRMKTEFLVQFDGATSSADDRILVIGATNRPHELDDAVLRRFPKRIMLNLPDEE 409
Query: 605 ERAEILKVTLKGERVEPDI---DYDHVARLCEGYTGSDIFELCKKAAYFPIREI 453
R E++ TLK + + D ++A G++ SD+ LCK+AA PIREI
Sbjct: 410 ARKELITKTLKKHNMMDGLISSDIRYIASNTSGFSNSDLVALCKEAAMVPIREI 463
>sp|A8XV40|SPAST_CAEBR Probable spastin homolog spas-1 OS=Caenorhabditis
briggsae GN=spas-1 PE=3 SV=2
Length = 542
Score = 201 bits (510), Expect = 1e-050
Identities = 103/234 (44%), Positives = 147/234 (62%), Gaps = 5/234 (2%)
Frame = -3
Query: 1145 DHIDVEFGSIGGLETIKEALYELVILPSKRPELFAYGKLLGPQKGVLLYGPPGTGKTMLA 966
D V + G + K L E VILP+ P LF+ L P KG+LL+GPPG GKT+LA
Sbjct: 262 DSTGVRMDDVAGCHSAKATLEEAVILPALNPNLFS--GLRQPVKGILLFGPPGNGKTLLA 319
Query: 965 KAIAKESGAVFINVRVSNLMSKWFGDAQKLVAAVFSLAYKLQPAIIFIDEVDSFLGQRRS 786
KA+A ES +F N+ S+L SKW GD++K + +F +A QP+IIFIDE+DS L +R
Sbjct: 320 KAVAGESKQMFFNISASSLTSKWVGDSEKTIRGLFQIARNGQPSIIFIDEIDSILCERSE 379
Query: 785 TDHEAMANMKTEFMALWDGFSTDPNARVMVLAATNRPSELDEAILRRLPQAFEIGMPDRK 606
D E MKTEF+ +DG ++ P+ R++V+ ATNRP ELD+A+LRR P+ + +PD +
Sbjct: 380 KDAEVSRRMKTEFLVQFDGATSSPDDRILVIGATNRPYELDDAVLRRFPKRIMLNLPDTE 439
Query: 605 ERAEILKVTLKGERVEPDI---DYDHVARLCEGYTGSDIFELCKKAAYFPIREI 453
R E++ TLK + + D ++A G++ SD+ LCK+AA P+REI
Sbjct: 440 ARKELITNTLKKHDMMDGLSSSDIRYIASNTSGFSNSDLVALCKEAAMVPVREI 493
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,436,365,428
Number of Sequences: 518415
Number of Extensions: 75436365428
Number of Successful Extensions: 513409628
Number of sequences better than 0.0: 0
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