BLASTX 7.6.2
Query= UN18607 /QuerySize=1272
(1271 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabi... 170 3e-041
sp|Q66L42|M3K10_MOUSE Mitogen-activated protein kinase kinase ki... 161 2e-038
sp|Q3U1V8|M3K9_MOUSE Mitogen-activated protein kinase kinase kin... 159 5e-038
sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kin... 158 1e-037
sp|Q7T2V3|M3K10_XENLA Mitogen-activated protein kinase kinase ki... 157 2e-037
sp|Q02779|M3K10_HUMAN Mitogen-activated protein kinase kinase ki... 156 5e-037
sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase ki... 153 3e-036
sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase ki... 153 3e-036
sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kina... 153 3e-036
sp|P18160|PYK1_DICDI Dual specificity protein kinase pyk1 OS=Dic... 137 2e-031
sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kin... 132 8e-030
sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kin... 131 1e-029
sp|Q05609|CTR1_ARATH Serine/threonine-protein kinase CTR1 OS=Ara... 130 2e-029
sp|Q23915|KINX_DICDI Probable serine/threonine-protein kinase ki... 119 5e-026
sp|A8X775|DLK1_CAEBR Mitogen-activated protein kinase kinase kin... 109 4e-023
sp|O01700|DLK1_CAEEL Mitogen-activated protein kinase kinase kin... 109 7e-023
sp|Q869N2|PAKB_DICDI Serine/threonine-protein kinase pakB OS=Dic... 94 2e-018
sp|Q03963|E2AK2_MOUSE Interferon-induced, double-stranded RNA-ac... 92 5e-018
sp|Q55GV3|PAKC_DICDI Serine/threonine-protein kinase pakC OS=Dic... 87 2e-016
sp|P43057|KPC1_CANAL Protein kinase C-like 1 OS=Candida albicans... 84 3e-015
>sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabidopsis thaliana
GN=HT1 PE=1 SV=1
Length = 390
Score = 170 bits (429), Expect = 3e-041
Identities = 77/182 (42%), Positives = 121/182 (66%), Gaps = 1/182 (0%)
Frame = -1
Query: 854 CVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKVIVHRDVKSENMLL 675
C++ EY++ G L+ +L KK L I+ V++LALD++RG+ YLHS+ ++HRD+KS N+LL
Sbjct: 161 CIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQGVIHRDLKSNNLLL 220
Query: 674 EPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEI 495
+K+ADFG + +E Q ++ G GT +MAPE+++ K Y RK DVYSFG+ LWE+
Sbjct: 221 NDEMRVKVADFGTSCLETQ-CREAKGNMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLWEL 279
Query: 494 YCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKL 315
+P+ + + + AV KN RP +P C ++A++++RCW NP KRP+ +V +
Sbjct: 280 TTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLIKRCWSENPSKRPDFSNIVAV 339
Query: 314 LE 309
LE
Sbjct: 340 LE 341
>sp|Q66L42|M3K10_MOUSE Mitogen-activated protein kinase kinase kinase 10 OS=Mus
musculus GN=Map3k10 PE=2 SV=2
Length = 940
Score = 161 bits (405), Expect = 2e-038
Identities = 103/325 (31%), Positives = 164/325 (50%), Gaps = 44/325 (13%)
Frame = -1
Query: 1226 GQSSSSSASAAVKSRKSPMQ-EWEIDLSKLDMNQVLARGTYGTAYRGVYAGQQVAVKV-- 1056
G S+ + A + S +Q EI +L + +++ G +G YR V+ G++VAVK
Sbjct: 69 GVFPSNYVAPAAPAAPSDLQLPQEIPFHELQLEEIIGVGGFGKVYRAVWRGEEVAVKAAR 128
Query: 1055 LDWGEDGVSTADDLRISFEQEVAVWQKLHHPNVTKFIGAPMGTSDLKIPSSSDSVGHGNS 876
LD D TA+ +R QE ++ L HPN+ GA + +L
Sbjct: 129 LDPERDPAVTAEQVR----QEARLFGALQHPNIIALRGACLSPPNL-------------- 170
Query: 875 AHPAKACCVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKV---IVH 705
C+V+EY GG L + L + ++P ++ A+ +ARG++YLH+ I+H
Sbjct: 171 -------CLVMEYARGGALSRVLAGR---RVPPHVLVNWAVQVARGMNYLHNDAPVPIIH 220
Query: 704 RDVKSENMLL--------EPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGK 549
RD+KS N+L+ + LKI DFG+AR E M+ GT +MAPEV+
Sbjct: 221 RDLKSINILILEAIENHNLADTVLKITDFGLAR-EWHKTTKMSA-AGTYAWMAPEVIRLS 278
Query: 548 AYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRR 369
+++ DV+SFGV LWE+ ++PY + +++ V L IP CP+ A ++
Sbjct: 279 LFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEE 338
Query: 368 CWDPNPDKRPEMEEVVKLLEAVNTS 294
CWDP+P RP+ ++K LE + S
Sbjct: 339 CWDPDPHGRPDFGSILKQLEVIEQS 363
>sp|Q3U1V8|M3K9_MOUSE Mitogen-activated protein kinase kinase kinase 9 OS=Mus
musculus GN=Map3k9 PE=2 SV=1
Length = 1077
Score = 159 bits (401), Expect = 5e-038
Identities = 107/337 (31%), Positives = 166/337 (49%), Gaps = 45/337 (13%)
Frame = -1
Query: 1220 SSSSSASAAVKSRKSPMQEWEIDLSKLDMNQVLARGTYGTAYRGVYAGQQVAVKVL--DW 1047
SS A S P+Q EID ++L + +++ G +G YR +AG +VAVK D
Sbjct: 111 SSRCQPGAEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWAGDEVAVKAARHDP 170
Query: 1046 GEDGVSTADDLRISFEQEVAVWQKLHHPNVTKFIGAPMGTSDLKIPSSSDSVGHGNSAHP 867
ED T +++R QE ++ L HPN+ G + +L
Sbjct: 171 DEDISQTIENVR----QEAKLFAMLKHPNIIALRGVCLKEPNL----------------- 209
Query: 866 AKACCVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKVIV---HRDV 696
C+V+E+ GG L + L K ++P ++ A+ +ARG++YLH + IV HRD+
Sbjct: 210 ----CLVMEFARGGPLNRVLSGK---RIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDL 262
Query: 695 KSENMLL--------EPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYN 540
KS N+L+ NK L+I DFG+AR E M+ GT +MAPEV+ ++
Sbjct: 263 KSSNILILQKVENGDLSNKILEITDFGLAR-EWHRTTKMSA-AGTYAWMAPEVIRASMFS 320
Query: 539 RKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWD 360
+ DV+S+GV LWE+ ++P+ +++ V L IP CP+ A +M CW+
Sbjct: 321 KGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWN 380
Query: 359 PNPDKRPEMEEVVKLLEAVNTSKGGGMIPPDKFQGCL 249
P+P RP ++ L + S G +P D F CL
Sbjct: 381 PDPHSRPSFTSILDQLTTIEES-GFFEMPKDSFH-CL 415
>sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 OS=Homo
sapiens GN=MAP3K9 PE=1 SV=3
Length = 1104
Score = 158 bits (398), Expect = 1e-037
Identities = 103/322 (31%), Positives = 161/322 (50%), Gaps = 45/322 (13%)
Frame = -1
Query: 1175 PMQEWEIDLSKLDMNQVLARGTYGTAYRGVYAGQQVAVKVL--DWGEDGVSTADDLRISF 1002
P+Q EID ++L + +++ G +G YR + G +VAVK D ED T +++R
Sbjct: 133 PIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVR--- 189
Query: 1001 EQEVAVWQKLHHPNVTKFIGAPMGTSDLKIPSSSDSVGHGNSAHPAKACCVVVEYVAGGT 822
QE ++ L HPN+ G + +L C+V+E+ GG
Sbjct: 190 -QEAKLFAMLKHPNIIALRGVCLKEPNL---------------------CLVMEFARGGP 227
Query: 821 LKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKVIV---HRDVKSENMLL-------- 675
L + L K ++P ++ A+ +ARG++YLH + IV HRD+KS N+L+
Sbjct: 228 LNRVLSGK---RIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGD 284
Query: 674 EPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEI 495
NK LKI DFG+AR E M+ GT +MAPEV+ +++ DV+S+GV LWE+
Sbjct: 285 LSNKILKITDFGLAR-EWHRTTKMSA-AGTYAWMAPEVIRASMFSKGSDVWSYGVLLWEL 342
Query: 494 YCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKL 315
++P+ +++ V L IP CP+ A +M CW+P+P RP ++
Sbjct: 343 LTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQ 402
Query: 314 LEAVNTSKGGGMIPPDKFQGCL 249
L + S G +P D F CL
Sbjct: 403 LTTIEES-GFFEMPKDSFH-CL 422
>sp|Q7T2V3|M3K10_XENLA Mitogen-activated protein kinase kinase kinase 10
OS=Xenopus laevis GN=map3k10 PE=1 SV=1
Length = 1005
Score = 157 bits (396), Expect = 2e-037
Identities = 97/302 (32%), Positives = 157/302 (51%), Gaps = 43/302 (14%)
Frame = -1
Query: 1160 EIDLSKLDMNQVLARGTYGTAYRGVYAGQQVAVKVL--DWGEDGVSTADDLRISFEQEVA 987
EI+ +L++++++ G +G Y+G++ ++VAVK + D ED TA+++R QE
Sbjct: 112 EIEFDELNLDEIIGVGGFGKVYKGLWRDEEVAVKAVRHDPDEDINVTAENVR----QEAK 167
Query: 986 VWQKLHHPNVTKFIGAPMGTSDLKIPSSSDSVGHGNSAHPAKACCVVVEYVAGGTLKKFL 807
++ L HPN+ G + L C+V+EY GG L + L
Sbjct: 168 IFCMLCHPNIIALTGVCLKPPHL---------------------CLVMEYARGGPLHRAL 206
Query: 806 IKKYRTKLPIKDVIQLALDLARGLSYLHSKVIV---HRDVKSENMLLEP--------NKT 660
K K+P ++ A+ +A+G++YLH++ IV HRD+ S N+L+ NKT
Sbjct: 207 AGK---KVPAHVLVNWAVQIAKGMTYLHNEAIVPIIHRDLGSSNILILEKAENDDLFNKT 263
Query: 659 LKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDM 480
L I DFG+AR E Q M+ GT +MAPEV+ +++ DV+SFGV LWE+ ++
Sbjct: 264 LNITDFGLAR-EWQKTTKMSA-AGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEV 321
Query: 479 PYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLEAVN 300
PY + +++ V L IP CP+ I+ CWDP+P RP +++ L +
Sbjct: 322 PYREIDALAVAYGVAMNKLTLPIPSTCPEPFVRILEACWDPDPHSRPTFSCILEQLTTIE 381
Query: 299 TS 294
S
Sbjct: 382 QS 383
>sp|Q02779|M3K10_HUMAN Mitogen-activated protein kinase kinase kinase 10 OS=Homo
sapiens GN=MAP3K10 PE=1 SV=3
Length = 954
Score = 156 bits (392), Expect = 5e-037
Identities = 96/302 (31%), Positives = 154/302 (50%), Gaps = 43/302 (14%)
Frame = -1
Query: 1160 EIDLSKLDMNQVLARGTYGTAYRGVYAGQQVAVKV--LDWGEDGVSTADDLRISFEQEVA 987
EI +L + +++ G +G YR ++ G++VAVK LD +D TA+ + QE
Sbjct: 92 EIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVC----QEAR 147
Query: 986 VWQKLHHPNVTKFIGAPMGTSDLKIPSSSDSVGHGNSAHPAKACCVVVEYVAGGTLKKFL 807
++ L HPN+ GA + L C+V+EY GG L + L
Sbjct: 148 LFGALQHPNIIALRGACLNPPHL---------------------CLVMEYARGGALSRVL 186
Query: 806 IKKYRTKLPIKDVIQLALDLARGLSYLHSKV---IVHRDVKSENMLL--------EPNKT 660
+ ++P ++ A+ +ARG++YLH+ I+HRD+KS N+L+ +
Sbjct: 187 AGR---RVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTV 243
Query: 659 LKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDM 480
LKI DFG+AR E M+ GT +MAPEV+ +++ DV+SFGV LWE+ ++
Sbjct: 244 LKITDFGLAR-EWHKTTKMSA-AGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEV 301
Query: 479 PYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLLEAVN 300
PY + +++ V L IP CP+ A ++ CWDP+P RP+ ++K LE +
Sbjct: 302 PYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIE 361
Query: 299 TS 294
S
Sbjct: 362 QS 363
>sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 OS=Homo
sapiens GN=MAP3K11 PE=1 SV=1
Length = 847
Score = 153 bits (385), Expect = 3e-036
Identities = 102/327 (31%), Positives = 162/327 (49%), Gaps = 44/327 (13%)
Frame = -1
Query: 1244 WDLNMGGQSSSSSASAAVKSRKSPMQEWEIDLSKLDMNQVLARGTYGTAYRGVYAGQQVA 1065
W +GGQ ++ + P E +L + +V+ G +G YRG + G+ VA
Sbjct: 84 WAGQVGGQVGIFPSNYVSRGGGPPPCE-VASFQELRLEEVIGIGGFGKVYRGSWRGELVA 142
Query: 1064 VKVL--DWGEDGVSTADDLRISFEQEVAVWQKLHHPNVTKFIGAPMGTSDLKIPSSSDSV 891
VK D ED TA+ +R QE ++ L HPN+ + +L
Sbjct: 143 VKAARQDPDEDISVTAESVR----QEARLFAMLAHPNIIALKAVCLEEPNL--------- 189
Query: 890 GHGNSAHPAKACCVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKV- 714
C+V+EY AGG L + L + ++P ++ A+ +ARG+ YLH +
Sbjct: 190 ------------CLVMEYAAGGPLSRALAGR---RVPPHVLVNWAVQIARGMHYLHCEAL 234
Query: 713 --IVHRDVKSEN-MLLEP-------NKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPE 564
++HRD+KS N +LL+P +KTLKI DFG+AR + Q GT +MAPE
Sbjct: 235 VPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQ--MSAAGTYAWMAPE 292
Query: 563 VLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVA 384
V++ +++ DV+SFGV LWE+ ++PY +++ V L IP CP+ A
Sbjct: 293 VIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFA 352
Query: 383 NIMRRCWDPNPDKRPEMEEVVKLLEAV 303
+M CW +P +RP+ +++ LEA+
Sbjct: 353 QLMADCWAQDPHRRPDFASILQQLEAL 379
>sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase kinase 11 OS=Mus
musculus GN=Map3k11 PE=1 SV=1
Length = 850
Score = 153 bits (385), Expect = 3e-036
Identities = 102/327 (31%), Positives = 162/327 (49%), Gaps = 44/327 (13%)
Frame = -1
Query: 1244 WDLNMGGQSSSSSASAAVKSRKSPMQEWEIDLSKLDMNQVLARGTYGTAYRGVYAGQQVA 1065
W +GGQ ++ + P E +L + +V+ G +G YRG + G+ VA
Sbjct: 85 WAGQVGGQVGIFPSNYVSRGGGPPPCE-VASFQELRLEEVIGIGGFGKVYRGSWRGELVA 143
Query: 1064 VKVL--DWGEDGVSTADDLRISFEQEVAVWQKLHHPNVTKFIGAPMGTSDLKIPSSSDSV 891
VK D ED TA+ +R QE ++ L HPN+ + +L
Sbjct: 144 VKAARQDPDEDISVTAESVR----QEARLFAMLAHPNIIALKAVCLEEPNL--------- 190
Query: 890 GHGNSAHPAKACCVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKV- 714
C+V+EY AGG L + L + ++P ++ A+ +ARG+ YLH +
Sbjct: 191 ------------CLVMEYAAGGPLSRALAGR---RVPPHVLVNWAVQIARGMHYLHCEAL 235
Query: 713 --IVHRDVKSEN-MLLEP-------NKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPE 564
++HRD+KS N +LL+P +KTLKI DFG+AR + Q GT +MAPE
Sbjct: 236 VPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQ--MSAAGTYAWMAPE 293
Query: 563 VLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVA 384
V++ +++ DV+SFGV LWE+ ++PY +++ V L IP CP+ A
Sbjct: 294 VIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFA 353
Query: 383 NIMRRCWDPNPDKRPEMEEVVKLLEAV 303
+M CW +P +RP+ +++ LEA+
Sbjct: 354 QLMADCWAQDPHRRPDFASILQQLEAL 380
>sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kinase 11 OS=Rattus
norvegicus GN=Map3k11 PE=2 SV=1
Length = 850
Score = 153 bits (385), Expect = 3e-036
Identities = 102/327 (31%), Positives = 162/327 (49%), Gaps = 44/327 (13%)
Frame = -1
Query: 1244 WDLNMGGQSSSSSASAAVKSRKSPMQEWEIDLSKLDMNQVLARGTYGTAYRGVYAGQQVA 1065
W +GGQ ++ + P E +L + +V+ G +G YRG + G+ VA
Sbjct: 85 WAGQVGGQVGIFPSNYVSRGGGPPPCE-VASFQELRLEEVIGIGGFGKVYRGSWRGELVA 143
Query: 1064 VKVL--DWGEDGVSTADDLRISFEQEVAVWQKLHHPNVTKFIGAPMGTSDLKIPSSSDSV 891
VK D ED TA+ +R QE ++ L HPN+ + +L
Sbjct: 144 VKAARQDPDEDISVTAESVR----QEARLFAMLAHPNIIALKAVCLEEPNL--------- 190
Query: 890 GHGNSAHPAKACCVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKV- 714
C+V+EY AGG L + L + ++P ++ A+ +ARG+ YLH +
Sbjct: 191 ------------CLVMEYAAGGPLSRALAGR---RVPPHVLVNWAVQIARGMHYLHCEAL 235
Query: 713 --IVHRDVKSEN-MLLEP-------NKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPE 564
++HRD+KS N +LL+P +KTLKI DFG+AR + Q GT +MAPE
Sbjct: 236 VPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQ--MSAAGTYAWMAPE 293
Query: 563 VLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVA 384
V++ +++ DV+SFGV LWE+ ++PY +++ V L IP CP+ A
Sbjct: 294 VIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFA 353
Query: 383 NIMRRCWDPNPDKRPEMEEVVKLLEAV 303
+M CW +P +RP+ +++ LEA+
Sbjct: 354 QLMADCWAQDPHRRPDFASILQQLEAL 380
>sp|P18160|PYK1_DICDI Dual specificity protein kinase pyk1 OS=Dictyostelium
discoideum GN=splA PE=1 SV=3
Length = 2410
Score = 137 bits (344), Expect = 2e-031
Identities = 93/332 (28%), Positives = 155/332 (46%), Gaps = 43/332 (12%)
Frame = -1
Query: 1247 KWDLNMGGQSSSSSASAAVKSRKSP----------MQEWEIDLSKLDMNQVLARGTYGTA 1098
KW GG + SS S SR P E+EID ++L+ Q + +G +G
Sbjct: 2071 KWIDPFGGWETQSSLSHP-PSRPPPPPPPPPQLPVRSEYEIDFNELEFGQTIGKGFFGEV 2129
Query: 1097 YRGVYAGQQVAVKVLDWGEDGVSTADDLRISFEQEVAVWQKLHHPNVTKFIGAPMGTSDL 918
RG + VA+K++ D T L + F+ EV + KL HPNV +F+GA +
Sbjct: 2130 KRGYWRETDVAIKII--YRDQFKTKSSL-VMFQNEVGILSKLRHPNVVQFLGACTAGGED 2186
Query: 917 KIPSSSDSVGHGNSAHPAKACCVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARG 738
++ +G G+ + F + + + +K + +A +
Sbjct: 2187 HHCIVTEWMGGGS--------------LRQFLTDHFNLLEQNPHIRLKLALDIAKGM--N 2230
Query: 737 LSYLHSKVIVHRDVKSENMLLEPN-------------KTLKIADFGVARVEAQNPQDMTG 597
+ + I+HRD+ S N+LL+ N KI+DFG++R++ + MT
Sbjct: 2231 YLHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKMEQASQMTQ 2290
Query: 596 ETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHKNLRP 417
G + YMAPEV +G + + K DVYS+G+ L+E+ D P D +++H +++ RP
Sbjct: 2291 SVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLTSDEPQQDMKPMKMAHLAAYESYRP 2350
Query: 416 EIPKCCPQSVANIMRRCWDPNPDKRPEMEEVV 321
IP I+ +CWD NPD RP ++++
Sbjct: 2351 PIPLTTSSKWKEILTQCWDSNPDSRPTFKQII 2382
>sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kinase MLT OS=Mus
musculus GN=Mltk PE=1 SV=1
Length = 802
Score = 132 bits (330), Expect = 8e-030
Identities = 61/187 (32%), Positives = 110/187 (58%), Gaps = 5/187 (2%)
Frame = -1
Query: 851 VVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKV---IVHRDVKSENM 681
+V EY + G+L ++ ++ ++ ++ A D+A+G+ YLH + ++HRD+KS N+
Sbjct: 80 IVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNV 139
Query: 680 LLEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLW 501
++ + LKI DFG +R N GT +MAPEV++ + CD YS+GV LW
Sbjct: 140 VIAADGVLKICDFGASRF--HNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLW 197
Query: 500 EIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVV 321
E+ ++P+ +++ VV KN R IP CP+S A ++ +CW+ + KRP ++++
Sbjct: 198 EMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQII 257
Query: 320 KLLEAVN 300
+LE+++
Sbjct: 258 SILESMS 264
>sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kinase MLT OS=Homo
sapiens GN=MLTK PE=1 SV=2
Length = 800
Score = 131 bits (328), Expect = 1e-029
Identities = 61/187 (32%), Positives = 109/187 (58%), Gaps = 5/187 (2%)
Frame = -1
Query: 851 VVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKV---IVHRDVKSENM 681
+V EY + G+L ++ ++ + ++ A D+A+G+ YLH + ++HRD+KS N+
Sbjct: 80 IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNV 139
Query: 680 LLEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLW 501
++ + LKI DFG +R N GT +MAPEV++ + CD YS+GV LW
Sbjct: 140 VIAADGVLKICDFGASRF--HNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLW 197
Query: 500 EIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVV 321
E+ ++P+ +++ VV KN R IP CP+S A ++ +CW+ + KRP ++++
Sbjct: 198 EMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQII 257
Query: 320 KLLEAVN 300
+LE+++
Sbjct: 258 SILESMS 264
>sp|Q05609|CTR1_ARATH Serine/threonine-protein kinase CTR1 OS=Arabidopsis
thaliana GN=CTR1 PE=1 SV=1
Length = 821
Score = 130 bits (326), Expect = 2e-029
Identities = 75/197 (38%), Positives = 114/197 (57%), Gaps = 7/197 (3%)
Frame = -1
Query: 851 VVVEYVAGGTLKKFLIKK-YRTKLPIKDVIQLALDLARGLSYLHSK--VIVHRDVKSENM 681
+V EY++ G+L + L K R +L + + +A D+A+G++YLH++ IVHRD+KS N+
Sbjct: 623 IVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNL 682
Query: 680 LLEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLW 501
L++ T+K+ DFG++R++A GT +MAPEVL + N K DVYSFGV LW
Sbjct: 683 LVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILW 742
Query: 500 EIYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVV 321
E+ P+ + + A++ AV K R EIP+ VA I+ CW P KRP ++
Sbjct: 743 ELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIM 802
Query: 320 KLLEAVNTSKGGGMIPP 270
LL + S +PP
Sbjct: 803 DLLRPLIKS----AVPP 815
>sp|Q23915|KINX_DICDI Probable serine/threonine-protein kinase kinX
OS=Dictyostelium discoideum GN=kinX PE=3 SV=2
Length = 1094
Score = 119 bits (297), Expect = 5e-026
Identities = 72/199 (36%), Positives = 114/199 (57%), Gaps = 10/199 (5%)
Frame = -1
Query: 851 VVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKVIVHRDVKSENMLLE 672
+V E + GG L+ +L K LP +ALD++ +SYLHSK IVHRD+KS N+L++
Sbjct: 97 IVTELIEGGDLQYYL-KNQSIDLPWFLRANIALDVSLAMSYLHSKSIVHRDLKSTNLLVD 155
Query: 671 PNKTLKIADFGVAR-VEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEI 495
N +K+ DFG AR VE N + MT GT +M+PE++ G Y+ + D++SFG+ L EI
Sbjct: 156 KNWKIKVCDFGFARIVEEDNNKSMT-ICGTDNWMSPEMITGLDYDERSDIFSFGIVLLEI 214
Query: 494 YCCDMP---YADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEV 324
P D SF ++ +V L IP CP+S+ ++ C +P+ RP +E+
Sbjct: 215 ISRVKPAPYMRDASFG-LAEDIVRNQL---IPTDCPESLIDLTFNCCSVDPNNRPSFKEI 270
Query: 323 VKLLEAVNTSKGGGMIPPD 267
+ L+ + T+ ++ P+
Sbjct: 271 SQTLKQIKTTLDSNIVYPE 289
>sp|A8X775|DLK1_CAEBR Mitogen-activated protein kinase kinase kinase dlk-1
OS=Caenorhabditis briggsae GN=dlk-1 PE=3 SV=1
Length = 857
Score = 109 bits (272), Expect = 4e-023
Identities = 58/178 (32%), Positives = 97/178 (54%), Gaps = 4/178 (2%)
Frame = -1
Query: 854 CVVVEYVAGGTLKKFLIKK-YRTKLPIKDVIQLALDLARGLSYLHSKVIVHRDVKSENML 678
C+V+EY G L L +K T+ D ++ ++A G+ YLH ++HRD+KS N+L
Sbjct: 124 CIVMEYCPKGQLCTVLRQKNLITRQMFSDWVK---EIADGMHYLHQNKVIHRDLKSPNIL 180
Query: 677 LEPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWE 498
+ ++KI DFG + ++ +N M GT+ +MAPE+++ + N K DVYSFGV LWE
Sbjct: 181 ISAEDSIKICDFGTSHLQKKNDSTMMSFCGTVSWMAPEMIKKEPCNEKVDVYSFGVVLWE 240
Query: 497 IYCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEV 324
+ + PYA+ + I V L +P+ P+ + ++++C RP +
Sbjct: 241 MLTRETPYANIAQMAIIFGVGTNILNLPMPEEAPRGLVLLIKQCLSQKGRNRPSFSHI 298
>sp|O01700|DLK1_CAEEL Mitogen-activated protein kinase kinase kinase dlk-1
OS=Caenorhabditis elegans GN=dlk-1 PE=1 SV=4
Length = 928
Score = 109 bits (270), Expect = 7e-023
Identities = 57/177 (32%), Positives = 95/177 (53%), Gaps = 2/177 (1%)
Frame = -1
Query: 854 CVVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKVIVHRDVKSENMLL 675
C+V+EY + G L L K R + + Q ++A G+ YLH ++HRD+KS N+L+
Sbjct: 197 CIVMEYCSKGQLCTVL--KSRNTITRELFAQWVKEIADGMHYLHQNKVIHRDLKSPNILI 254
Query: 674 EPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEI 495
++KI DFG + ++ + M GT+ +MAPE+++ + N K DVYSFGV LWE+
Sbjct: 255 SAEDSIKICDFGTSHMQKKMDSTMMSFCGTVSWMAPEMIKKQPCNEKVDVYSFGVVLWEM 314
Query: 494 YCCDMPYADCSFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEV 324
+ PYA+ + I V L +P+ P+ + ++++C RP +
Sbjct: 315 LTRETPYANIAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHI 371
>sp|Q869N2|PAKB_DICDI Serine/threonine-protein kinase pakB OS=Dictyostelium
discoideum GN=pakB PE=1 SV=1
Length = 852
Score = 94 bits (231), Expect = 2e-018
Identities = 53/195 (27%), Positives = 100/195 (51%), Gaps = 3/195 (1%)
Frame = -1
Query: 851 VVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKVIVHRDVKSENMLLE 672
V +E++ GG L + L + KL + + + +GL+Y+HS+ +HRD+KS+N+LL
Sbjct: 641 VAMEFMGGGCLTEILEQFNSVKLVEAQIAYVCAETLKGLAYIHSQHRIHRDIKSDNILLG 700
Query: 671 PNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIY 492
+ ++K+ADFG A ++ Q GT +MAPE++ G+ Y+RK D++S G+ E+
Sbjct: 701 SDGSVKLADFGYAAQLTKSKQKRVTIVGTPYWMAPELIRGQNYDRKVDIWSLGIMAMEMA 760
Query: 491 CCDMPYADCSFAEISHAVVHKNLRPEI--PKCCPQSVANIMRRCWDPNPDKRPEMEEVVK 318
+ PY + K + P++ + +++C D + + RPE + ++
Sbjct: 761 ESEPPYMSFPPLRALFLITTKGI-PDLKDQNKWSDDFKDFVKKCLDKDVENRPEAKVLLN 819
Query: 317 LLEAVNTSKGGGMIP 273
G++P
Sbjct: 820 HPFLKTACNSNGLVP 834
>sp|Q03963|E2AK2_MOUSE Interferon-induced, double-stranded RNA-activated protein
kinase OS=Mus musculus GN=Eif2ak2 PE=1 SV=2
Length = 515
Score = 92 bits (228), Expect = 5e-018
Identities = 61/231 (26%), Positives = 110/231 (47%), Gaps = 12/231 (5%)
Frame = -1
Query: 1001 EQEVAVWQKLHHPNVTKFIGAPMGTSDLKIPSSSDSVGHGNSAHPAKACCVVVEYVAGGT 822
E EV +L+H N+ ++ G S SD+ S + + + +E+ GT
Sbjct: 281 EHEVQALAELNHVNIVQYHSCWEGVDYDPEHSMSDT-----SRYKTRCLFIQMEFCDKGT 335
Query: 821 LKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKVIVHRDVKSENMLLEPNKTLKIADF 642
L++++ + ++K+ ++ L + G+ Y+HSK ++HRD+K N+ L + +KI DF
Sbjct: 336 LEQWMRNRNQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDF 395
Query: 641 GVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWE-IYCCDMPYADC 465
G+A + + T TGTL YM+PE L K Y ++ D+++ G+ L E ++ C
Sbjct: 396 GLATALENDGKSRTRRTGTLQYMSPEQLFLKHYGKEVDIFALGLILAELLHTCFTESEKI 455
Query: 464 SFAEISHAVVHKNLRPEIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVKLL 312
F E N +++++ P RPE E++K L
Sbjct: 456 KFFESLRKGDFSN------DIFDNKEKSLLKKLLSEKPKDRPETSEILKTL 500
>sp|Q55GV3|PAKC_DICDI Serine/threonine-protein kinase pakC OS=Dictyostelium
discoideum GN=pakC PE=1 SV=1
Length = 493
Score = 87 bits (215), Expect = 2e-016
Identities = 54/180 (30%), Positives = 88/180 (48%), Gaps = 3/180 (1%)
Frame = -1
Query: 851 VVVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKVIVHRDVKSENMLLE 672
V +E++ GG L L K+ + + + + L Y+HS +HRD+KS+N+LL
Sbjct: 292 VAMEFMGGGCLTDILEAFDNIKMSEIQIAYVVKETLKALQYIHSLHRIHRDIKSDNILLG 351
Query: 671 PNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIY 492
++KIADFG A Q Q GT +MAPE++ G Y K D++S G+ + E+
Sbjct: 352 SEGSVKIADFGYAAQLTQKQQKRNTVVGTPYWMAPELIRGHDYGVKVDIWSLGIMMMEMA 411
Query: 491 CCDMPYADCSFAEISHAVVHKNLRP--EIPKCCPQSVANIMRRCWDPNPDKRPEMEEVVK 318
+ PY D + K + P E K ++ + +C D N RP+ +++K
Sbjct: 412 EGEPPYMDFPPLRALFLITTKGIPPLKETTK-WSKTFQDFFSKCLDINVANRPDATDLLK 470
>sp|P43057|KPC1_CANAL Protein kinase C-like 1 OS=Candida albicans GN=PKC1 PE=3
SV=1
Length = 1097
Score = 84 bits (205), Expect = 3e-015
Identities = 45/143 (31%), Positives = 79/143 (55%), Gaps = 3/143 (2%)
Frame = -1
Query: 848 VVEYVAGGTLKKFLIKKYRTKLPIKDVIQLALDLARGLSYLHSKVIVHRDVKSENMLLEP 669
V+EY++GG L + K + K A ++ GL Y H IV+RD+K +N+LL
Sbjct: 849 VMEYISGGDLMWHIQK---NRFTAKRAKFYACEVLLGLKYFHDNGIVYRDLKLDNILLTT 905
Query: 668 NKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKAYNRKCDVYSFGVCLWEIYC 489
+KI D+G+ + + + + GT +MAPE++ GKAY+R D ++FGV L+++
Sbjct: 906 KGHIKIGDYGLCKEDMWHKSTTSTFCGTPEFMAPEIVAGKAYDRSVDWWAFGVLLFQMLL 965
Query: 488 CDMPYADCSFAEISHAVVHKNLR 420
C P+ +I +A+ + ++
Sbjct: 966 CQSPFKGDDEDDIFNAIENDEVK 988
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,436,365,428
Number of Sequences: 518415
Number of Extensions: 75436365428
Number of Successful Extensions: 513409628
Number of sequences better than 0.0: 0
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