BLASTX 7.6.2
Query= UN18944 /QuerySize=2584
(2583 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9C509|SGPL_ARATH Sphingosine-1-phosphate lyase OS=Arabidopsi... 1000 1e-290
sp|Q52RG7|SGPL_ORYSJ Sphingosine-1-phosphate lyase OS=Oryza sati... 757 2e-217
sp|Q8CHN6|SGPL1_RAT Sphingosine-1-phosphate lyase 1 OS=Rattus no... 414 3e-114
sp|O95470|SGPL1_HUMAN Sphingosine-1-phosphate lyase 1 OS=Homo sa... 411 2e-113
sp|Q54RV9|SGPL_DICDI Sphingosine-1-phosphate lyase OS=Dictyostel... 410 4e-113
sp|Q8R0X7|SGPL1_MOUSE Sphingosine-1-phosphate lyase 1 OS=Mus mus... 407 2e-112
sp|Q5R4G0|SGPL1_PONAB Sphingosine-1-phosphate lyase 1 OS=Pongo a... 406 4e-112
sp|Q9V7Y2|SGPL_DROME Sphingosine-1-phosphate lyase OS=Drosophila... 395 9e-109
sp|Q05567|SGPL_YEAST Sphingosine-1-phosphate lyase OS=Saccharomy... 359 7e-098
sp|Q9Y194|SGPL_CAEEL Sphingosine-1-phosphate lyase OS=Caenorhabd... 343 5e-093
sp|A5ULW4|MFNA_METS3 L-tyrosine decarboxylase OS=Methanobrevibac... 211 2e-053
sp|Q9UZD5|MFNA_PYRAB L-tyrosine decarboxylase OS=Pyrococcus abys... 200 7e-050
sp|O58679|MFNA_PYRHO L-tyrosine decarboxylase OS=Pyrococcus hori... 198 2e-049
sp|Q5JJ82|MFNA_PYRKO L-tyrosine decarboxylase OS=Pyrococcus koda... 196 6e-049
sp|C5A2X8|MFNA_THEGJ L-tyrosine decarboxylase OS=Thermococcus ga... 192 2e-047
sp|Q8U1P6|MFNA_PYRFU L-tyrosine decarboxylase OS=Pyrococcus furi... 189 1e-046
sp|O27188|MFNA_METTH L-tyrosine decarboxylase OS=Methanobacteriu... 187 4e-046
sp|Q8PXA5|MFNA_METMA L-tyrosine decarboxylase OS=Methanosarcina ... 161 2e-038
sp|Q12VA2|MFNA_METBU L-tyrosine decarboxylase OS=Methanococcoide... 154 3e-036
sp|Q0W498|MFNA_UNCMA L-tyrosine decarboxylase OS=Uncultured meth... 145 2e-033
>sp|Q9C509|SGPL_ARATH Sphingosine-1-phosphate lyase OS=Arabidopsis thaliana
GN=At1g27980 PE=2 SV=1
Length = 544
Score = 1000 bits (2583), Expect = 1e-290
Identities = 495/544 (90%), Positives = 517/544 (95%)
Frame = +2
Query: 755 MDSLSFSSMKSMLIEARGSLNSRLSEFEPLALVFTPLITLFLAQVIGSVLGVVHEKGLKA 934
MDS S+SSMKSMLI+ARGSLNSRLSEFEPL L+ PL++LFLAQ+IGSV GVVHEKGLKA
Sbjct: 1 MDSFSYSSMKSMLIQARGSLNSRLSEFEPLVLLLVPLVSLFLAQIIGSVFGVVHEKGLKA 60
Query: 935 CLVGFIMGFFKKIPGVQSYIDAEKQKVVDQLQSGGNSKKNNWAKELPVRGLGVQVLEKME 1114
CL+GFIMG K IPGVQ+YIDAEKQKVVDQLQSG +SKK N + LPV+GLGV+VLEKME
Sbjct: 61 CLIGFIMGLLKMIPGVQNYIDAEKQKVVDQLQSGSSSKKKNKTEVLPVKGLGVEVLEKME 120
Query: 1115 SEKRNDPTWQGKCSGTVYIGGSESEGHFTLINQACSMFAHTNPLHIDVFQSVVRFESEVV 1294
+EKRND WQGKCSGTVYIGG+ESEGHF+LINQACSMFAHTNPLHIDVFQSVVRFESEVV
Sbjct: 121 NEKRNDAIWQGKCSGTVYIGGAESEGHFSLINQACSMFAHTNPLHIDVFQSVVRFESEVV 180
Query: 1295 AMTAALLGSKEAVSGEEICGNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHS 1474
AMTAALLGSKE SG +ICGNMTSGGTESIVLAVKSSRDYMKYKKGI RPEMIIPESGHS
Sbjct: 181 AMTAALLGSKETASGGQICGNMTSGGTESIVLAVKSSRDYMKYKKGITRPEMIIPESGHS 240
Query: 1475 AYDKAAQYFNIKLWRVPVGKDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQ 1654
AYDKAAQYF IKLWRVPV KDFRADVKA RRHINRNTIMIVGSAPGFPHGIIDPIEELGQ
Sbjct: 241 AYDKAAQYFKIKLWRVPVDKDFRADVKATRRHINRNTIMIVGSAPGFPHGIIDPIEELGQ 300
Query: 1655 LAFSYGICFHVDLCLGGFVLPFARKLGYEIPAFDFSVKGVTSISVDVHKYGLAPKGTSTV 1834
LA SYGICFHVDLCLGGFVLPFARKLGY+IP FDFSV+GVTSISVDVHKYGLAPKGTSTV
Sbjct: 301 LALSYGICFHVDLCLGGFVLPFARKLGYQIPPFDFSVQGVTSISVDVHKYGLAPKGTSTV 360
Query: 1835 LYRNHEIRKHQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIM 2014
LYRNHEIRKHQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYL+NT KIM
Sbjct: 361 LYRNHEIRKHQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLQNTSKIM 420
Query: 2015 EASKRLEEGVRGISELFVVGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIH 2194
EASKRLEEGVR I ELFV+GKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIH
Sbjct: 421 EASKRLEEGVREIHELFVIGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIH 480
Query: 2195 ICVTLQHVPVVDDFLQDLREAVETVKANPGPITGGLAPIYGAAGKMPDRGMVNELLVSFM 2374
IC+TLQHVPVVDDFL+DLREAVETVKANPGPITGGLAPIYGAAGKMPDRGMVNELLVSFM
Sbjct: 481 ICITLQHVPVVDDFLRDLREAVETVKANPGPITGGLAPIYGAAGKMPDRGMVNELLVSFM 540
Query: 2375 DSQY 2386
DSQY
Sbjct: 541 DSQY 544
>sp|Q52RG7|SGPL_ORYSJ Sphingosine-1-phosphate lyase OS=Oryza sativa subsp.
japonica GN=SPL PE=2 SV=2
Length = 539
Score = 757 bits (1952), Expect = 2e-217
Identities = 371/529 (70%), Positives = 431/529 (81%)
Frame = +2
Query: 794 IEARGSLNSRLSEFEPLALVFTPLITLFLAQVIGSVLGVVHEKGLKACLVGFIMGFFKKI 973
+ R + N LS +EPL L+ PL+ L A+ + + V ++GL+ L+ M K +
Sbjct: 9 LRLRDAANHHLSRYEPLVLLAAPLLALLAARTLHAAAAAVADRGLRTVLLALAMTAIKLL 68
Query: 974 PGVQSYIDAEKQKVVDQLQSGGNSKKNNWAKELPVRGLGVQVLEKMESEKRNDPTWQGKC 1153
PGV +YI+AEK+KVVDQLQSGG S K+ ELP GL QV+ +E+ K D WQGKC
Sbjct: 69 PGVSAYINAEKRKVVDQLQSGGTSTKSTLRTELPTVGLSNQVINDLETLKARDVNWQGKC 128
Query: 1154 SGTVYIGGSESEGHFTLINQACSMFAHTNPLHIDVFQSVVRFESEVVAMTAALLGSKEAV 1333
SGTVYI GSESEGHF LIN+A SMF+HTNPLH DVF+SV + E+EVVAMTAALLG KE
Sbjct: 129 SGTVYIAGSESEGHFALINKAYSMFSHTNPLHQDVFKSVAQLEAEVVAMTAALLGIKEKS 188
Query: 1334 SGEEICGNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFNIKL 1513
SG +ICGNMTSGGTESI+LAVK+SRDYM+ KKGI +PEMII ES HSAYDKAAQYFNIK+
Sbjct: 189 SGGQICGNMTSGGTESILLAVKTSRDYMRTKKGITKPEMIIAESAHSAYDKAAQYFNIKV 248
Query: 1514 WRVPVGKDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFHVDL 1693
RVPV K+F ADVK +R IN NTIM+VGSAPGFPHG+IDPIEELG+LA Y IC HVDL
Sbjct: 249 RRVPVNKEFLADVKGFKRCINGNTIMMVGSAPGFPHGLIDPIEELGELASRYDICLHVDL 308
Query: 1694 CLGGFVLPFARKLGYEIPAFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQFV 1873
CLGGFVLPFARKLGY IP FDF VKGVTSIS DVHKYGLAPKGTS VLY+NHEIRK F
Sbjct: 309 CLGGFVLPFARKLGYPIPPFDFCVKGVTSISTDVHKYGLAPKGTSIVLYKNHEIRKPYFF 368
Query: 1874 AVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEGVRGI 2053
+VTEW+GGLYVSPTIAGSRPG L+AGAWAAM SLG GY+ENTG IME SK+++ G+ I
Sbjct: 369 SVTEWTGGLYVSPTIAGSRPGGLIAGAWAAMTSLGLNGYMENTGHIMEVSKKIQRGIEDI 428
Query: 2054 SELFVVGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQHVPVVDD 2233
LFV+GKPDMT+VAFGS ++DIFEVNDIMSSKGWHLNALQRPNS+HICVTLQH + ++
Sbjct: 429 PGLFVIGKPDMTVVAFGSDSVDIFEVNDIMSSKGWHLNALQRPNSLHICVTLQHTVIYEE 488
Query: 2234 FLQDLREAVETVKANPGPITGGLAPIYGAAGKMPDRGMVNELLVSFMDS 2380
FL+DL+++V+TVKANPGPI+GG APIYGAAGKMPDRGMV ELLV FMD+
Sbjct: 489 FLKDLKDSVDTVKANPGPISGGRAPIYGAAGKMPDRGMVRELLVEFMDA 537
>sp|Q8CHN6|SGPL1_RAT Sphingosine-1-phosphate lyase 1 OS=Rattus norvegicus
GN=Sgpl1 PE=2 SV=1
Length = 568
Score = 414 bits (1062), Expect = 3e-114
Identities = 226/537 (42%), Positives = 325/537 (60%), Gaps = 18/537 (3%)
Frame = +2
Query: 797 EARGSLNSRLSEFEPLALVFTPLITLFLAQVIGSVLGVVHEKGLKACLVGFIMGFFKKIP 976
+A+ +N +++EP L+ ++ L + + + + L + + +K+P
Sbjct: 25 KAKNYVNGYCTKYEPWQLIAGSVLCTLLVVWVYEL--IFQPESLWSRFKNKLFRLIRKMP 82
Query: 977 GVQSYIDAEKQKVVDQLQSGGNSKK--NNWAKELPVRGLG-VQVLEKMESEKRNDPTWQ- 1144
+ I + K L K ++ K LP +GL +VLE+++ D WQ
Sbjct: 83 FIGRKIQQQLTKAKKDLVKNMPFLKLDKDYVKTLPAQGLSTAEVLERLKEYSSMDVFWQE 142
Query: 1145 GKCSGTVYIGGSESEGHFTLINQACSMFAHTNPLHIDVFQSVVRFESEVVAMTAALLGSK 1324
GK SG VY G + L+ QA F +NPLH D+F + + E+E+V MT +L
Sbjct: 143 GKASGAVYSGEPKLT---ELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMTCSLFN-- 197
Query: 1325 EAVSGEEICGNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFN 1504
G + CG +TSGGTESI++A K+ RD + +KGIK PE++ PES H+A+DKAA YF
Sbjct: 198 ---GGPDSCGCVTSGGTESILMACKAYRD-LALEKGIKTPEIVAPESAHAAFDKAAHYFG 253
Query: 1505 IKLWRVPVGKDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFH 1684
+K+ RV K+ DV+AM+R I+RNT M+V SAP FPHG+IDPI E+ +LA Y I FH
Sbjct: 254 MKIVRVAQKKNMEVDVRAMKRAISRNTAMLVCSAPQFPHGVIDPIPEVAKLAVKYKIPFH 313
Query: 1685 VDLCLGGFVLPFARKLGYEI-PAFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRK 1861
VD CLGGF++ F K GY + FDF VKGVTSIS D HKYG APKG+S V+Y N + RK
Sbjct: 314 VDACLGGFLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRK 373
Query: 1862 HQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEG 2041
+QF +W GG+Y SP+IAGSRPG ++A WAA+M GE GY+E T +I++ ++ L+
Sbjct: 374 YQFFVDADWQGGIYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSE 433
Query: 2042 VRGISELFVVGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQHV- 2218
+ I +F++G P ++++A GS DI+ ++++MS+KGW+ N LQ P SIH C+TL H
Sbjct: 434 LENIKNIFILGDPQLSVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTR 493
Query: 2219 -PVVDDFLQDLREAVETVKANPGPITGGLAPIYGAAGKMPDRGMVNELLVSFMDSQY 2386
V FL+D+RE+V + NP T G+ IYG A DR MV E+ F+DS Y
Sbjct: 494 KRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQATIDRKMVAEISSVFLDSLY 550
>sp|O95470|SGPL1_HUMAN Sphingosine-1-phosphate lyase 1 OS=Homo sapiens GN=SGPL1
PE=1 SV=3
Length = 568
Score = 411 bits (1054), Expect = 2e-113
Identities = 227/537 (42%), Positives = 325/537 (60%), Gaps = 18/537 (3%)
Frame = +2
Query: 797 EARGSLNSRLSEFEPLALVFTPLITLFLAQVIGSVLGVVHEKGLKACLVGFIMGFFKKIP 976
+A+ +N +++EP L+ ++ L ++ V + L + +K+P
Sbjct: 25 KAKNYVNGHCTKYEPWQLIAWSVVWTLL--IVWGYEFVFQPESLWSRFKKKCFKLTRKMP 82
Query: 977 GVQSYIDAEKQKVVDQLQSGGNSKK--NNWAKELPVRGLGVQ-VLEKMESEKRNDPTWQ- 1144
+ I + K D + + K + K LP +GL VLEK++ D WQ
Sbjct: 83 IIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQE 142
Query: 1145 GKCSGTVYIGGSESEGHFTLINQACSMFAHTNPLHIDVFQSVVRFESEVVAMTAALLGSK 1324
G+ SGTVY G E L+ +A FA +NPLH D+F + + E+E+V + +L
Sbjct: 143 GRASGTVYSG---EEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFN-- 197
Query: 1325 EAVSGEEICGNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFN 1504
G + CG +TSGGTESI++A K+ RD + ++KGIK PE++ P+S H+A++KAA YF
Sbjct: 198 ---GGPDSCGCVTSGGTESILMACKAYRD-LAFEKGIKTPEIVAPQSAHAAFNKAASYFG 253
Query: 1505 IKLWRVPVGKDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFH 1684
+K+ RVP+ K DV+AMRR I+RNT M+V S P FPHG+IDP+ E+ +LA Y I H
Sbjct: 254 MKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLH 313
Query: 1685 VDLCLGGFVLPFARKLGYEIP-AFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRK 1861
VD CLGGF++ F K GY + FDF VKGVTSIS D HKYG APKG+S VLY + + R
Sbjct: 314 VDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRN 373
Query: 1862 HQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEG 2041
+QF T+W GG+Y SPTIAGSRPG + A WAA+M GE GY+E T +I++ ++ L+
Sbjct: 374 YQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSE 433
Query: 2042 VRGISELFVVGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQHV- 2218
+ I +FV G P ++++A GS+ DI+ ++++M++KGW+LN LQ P SIH C+TL H
Sbjct: 434 LENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHAR 493
Query: 2219 -PVVDDFLQDLREAVETVKANPGPITGGLAPIYGAAGKMPDRGMVNELLVSFMDSQY 2386
V FL+D+RE+V + NP T G+ IYG A DR MV EL F+DS Y
Sbjct: 494 KRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLY 550
>sp|Q54RV9|SGPL_DICDI Sphingosine-1-phosphate lyase OS=Dictyostelium discoideum
GN=sglA PE=2 SV=1
Length = 528
Score = 410 bits (1052), Expect = 4e-113
Identities = 209/476 (43%), Positives = 317/476 (66%), Gaps = 17/476 (3%)
Frame = +2
Query: 965 KKIPGVQSYIDAEKQKVVDQLQSGGNSKKNNWAKELPVRGLGVQ-VLEKMES-EKRNDPT 1138
K +PGV + E+ K +L+ + N LP++G+ + ++E+M++ K ++
Sbjct: 52 KSMPGVSDIVKKERAKAKVELKKMFKTDVRNAHYTLPLKGIKHEDLIEEMKALAKVDESH 111
Query: 1139 W-QGKCSGTVYIGGSESEGHFTLINQACSMFAHTNPLHIDVFQSVVRFESEVVAMTAALL 1315
W K SG VY+G E H L+N+A S+F+ +NPLH VF S+ +FE+E ++M + +L
Sbjct: 112 WVDSKVSGCVYLGEKE---HTKLLNEAYSLFSLSNPLHPSVFPSIRKFETESISMVSNML 168
Query: 1316 GSKEAVSGEEICGNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQ 1495
+ ++ G++TSGGTESI +AVK+ RD+ YK RPE+++P + H+A+DKA +
Sbjct: 169 NAH-----SKVVGSLTSGGTESIFMAVKAYRDF--YKDRTDRPEIVVPVTIHAAFDKACE 221
Query: 1496 YFNIKLWRVPVGK-DFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYG 1672
Y I++ + V ++ D+ AM++ IN++TI++ GSA FPHGIIDPI+E+ +LA Y
Sbjct: 222 YLKIRIVHIDVDPVSYKVDMAAMKKAINKDTILVAGSAVNFPHGIIDPIDEIAKLAQQYD 281
Query: 1673 ICFHVDLCLGGFVLPFARKLGYEIPAFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHE 1852
I HVD CLGGF+LPFA KL Y+IP FDF + GVTS+SVD HK+G A KGTS VL+ N +
Sbjct: 282 IGCHVDACLGGFILPFAEKLDYDIPVFDFRIPGVTSMSVDTHKFGYAAKGTSVVLFGNKK 341
Query: 1853 IRKHQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRL 2032
+R+ + W GG+Y SPT+ GSRPG LVA WA+++S+G +G+LE +ME +K++
Sbjct: 342 LRRAMYFVAPNWPGGIYASPTLPGSRPGGLVAACWASLVSMGNDGFLEKAKGVMETTKKI 401
Query: 2033 EEGVRGISELFVVGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQ 2212
+G++ I+ + ++G P +VAF +IF VND MS KGWHLNALQRPNS+H+CVT +
Sbjct: 402 IKGLQSINGVKIIGDPKAMVVAFTCD--NIFYVNDYMSKKGWHLNALQRPNSLHVCVTAK 459
Query: 2213 HVPVVDDFLQDLREAVETVKANPGPI-TGGLAPIYGAAGKMPDRGMVNELLVSFMD 2377
+ + F++DL+++++ VK N G + G APIYG+A +PDR MV +L F+D
Sbjct: 460 MIGMESLFIEDLKDSIKLVKDNSGSLPKDGTAPIYGSAHSVPDREMVGTILSDFID 515
>sp|Q8R0X7|SGPL1_MOUSE Sphingosine-1-phosphate lyase 1 OS=Mus musculus GN=Sgpl1
PE=2 SV=1
Length = 568
Score = 407 bits (1045), Expect = 2e-112
Identities = 223/544 (40%), Positives = 329/544 (60%), Gaps = 20/544 (3%)
Frame = +2
Query: 779 MKSMLIEARGSLNSRLSEFEPLALV-FTPLITLFLAQVIGSVLGVVHEKGLKACLVGFIM 955
++S +A+ +N +++EP L+ ++ L TL + V + + L + +
Sbjct: 19 LESYSTKAKNYVNGYCTKYEPWQLIAWSVLCTLLIVWVYELIF---QPESLWSRFKKKLF 75
Query: 956 GFFKKIPGVQSYIDAEKQKVVDQLQSGGNSKK--NNWAKELPVRGLG-VQVLEKMESEKR 1126
+K+P + I+ + K L K ++ K LP +G+G +VLE+++
Sbjct: 76 KLIRKMPFIGRKIEQQVSKAKKDLVKNMPFLKVDKDYVKTLPAQGMGTAEVLERLKEYSS 135
Query: 1127 NDPTWQ-GKCSGTVYIGGSESEGHFTLINQACSMFAHTNPLHIDVFQSVVRFESEVVAMT 1303
D +WQ GK SG VY G + L+ QA F +NPLH D+F + + E+E+V MT
Sbjct: 136 MDGSWQEGKASGAVYNGEPKLT---ELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMT 192
Query: 1304 AALLGSKEAVSGEEICGNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYD 1483
+L G + CG +TSGGTESI++A K+ RD + +KGIK PE++ PES H+A+D
Sbjct: 193 CSLFN-----GGPDSCGCVTSGGTESILMACKAYRD-LALEKGIKTPEIVAPESAHAAFD 246
Query: 1484 KAAQYFNIKLWRVPVGKDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAF 1663
KAA YF +K+ RV + K+ DV+AM+R I+RNT M+V S P FPHG++DP+ E+ +LA
Sbjct: 247 KAAHYFGMKIVRVALKKNMEVDVQAMKRAISRNTAMLVCSTPQFPHGVMDPVPEVAKLAV 306
Query: 1664 SYGICFHVDLCLGGFVLPFARKLGYEI-PAFDFSVKGVTSISVDVHKYGLAPKGTSTVLY 1840
Y I HVD CLGGF++ F K GY + FDF VKGVTSIS D HKYG APKG+S V+Y
Sbjct: 307 RYKIPLHVDACLGGFLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMY 366
Query: 1841 RNHEIRKHQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEA 2020
N + R +QF +W GG+Y SP+IAGSRPG ++A WAA+M GE GY+E T +I++
Sbjct: 367 SNEKYRTYQFFVGADWQGGVYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKT 426
Query: 2021 SKRLEEGVRGISELFVVGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHIC 2200
++ L+ + I +F+ G P ++++A GS DI+ ++++MS+KGW+ N LQ P SIH C
Sbjct: 427 ARFLKSELENIKNIFIFGDPQLSVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFC 486
Query: 2201 VTLQHV--PVVDDFLQDLREAVETVKANPGPITGGLAPIYGAAGKMPDRGMVNELLVSFM 2374
+TL H V FL+D+RE+V + NP T G+ IYG A DR +V E+ F+
Sbjct: 487 ITLVHTRKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQATIDRKLVAEISSVFL 546
Query: 2375 DSQY 2386
D Y
Sbjct: 547 DCLY 550
>sp|Q5R4G0|SGPL1_PONAB Sphingosine-1-phosphate lyase 1 OS=Pongo abelii GN=SGPL1
PE=2 SV=1
Length = 568
Score = 406 bits (1043), Expect = 4e-112
Identities = 226/537 (42%), Positives = 323/537 (60%), Gaps = 18/537 (3%)
Frame = +2
Query: 797 EARGSLNSRLSEFEPLALVFTPLITLFLAQVIGSVLGVVHEKGLKACLVGFIMGFFKKIP 976
+A+ +N +++EP L+ ++ L ++ V + L + +K+P
Sbjct: 25 KAKNYVNGHCTKYEPWQLIAWSVVWTLL--IVWGYEFVFQPESLWSRFKKKCFKLTRKMP 82
Query: 977 GVQSYIDAEKQKVVDQLQSGGNSKK--NNWAKELPVRGLGVQ-VLEKMESEKRNDPTWQ- 1144
+ I + K D + + K + K LP +GL VLEK++ D WQ
Sbjct: 83 IIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQE 142
Query: 1145 GKCSGTVYIGGSESEGHFTLINQACSMFAHTNPLHIDVFQSVVRFESEVVAMTAALLGSK 1324
G+ SGTVY G E L+ +A FA +NPLH D+F + + E+E+V + +L
Sbjct: 143 GRASGTVYSG---EEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFN-- 197
Query: 1325 EAVSGEEICGNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFN 1504
G + CG +TSGGTESI++A K+ RD + ++KGIK E++ P+S H+A++KAA YF
Sbjct: 198 ---GGPDSCGCVTSGGTESILMACKAYRD-LAFEKGIKTSEIVAPQSAHAAFNKAASYFG 253
Query: 1505 IKLWRVPVGKDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFH 1684
+K+ RVP+ K DV+AMRR I+RNT M+V S P FPHG+IDP+ E+ +LA Y I H
Sbjct: 254 MKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLH 313
Query: 1685 VDLCLGGFVLPFARKLGYEIP-AFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRK 1861
VD CLGGF+ F K GY + FDF VKGVTSIS D HKYG APKG+S VLY + + R
Sbjct: 314 VDACLGGFLTVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRN 373
Query: 1862 HQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEG 2041
+QF T+W GG+Y SPTIAGSRPG + A WAA+M GE GY+E T +I++ ++ L+
Sbjct: 374 YQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSE 433
Query: 2042 VRGISELFVVGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQHV- 2218
+ I +FV G P ++++A GS+ DI+ ++++M++KGW+LN LQ P SIH C+TL H
Sbjct: 434 LENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHAR 493
Query: 2219 -PVVDDFLQDLREAVETVKANPGPITGGLAPIYGAAGKMPDRGMVNELLVSFMDSQY 2386
V FL+D+RE+V + NP T G+ IYG A DR MV EL F+DS Y
Sbjct: 494 KRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLY 550
>sp|Q9V7Y2|SGPL_DROME Sphingosine-1-phosphate lyase OS=Drosophila melanogaster
GN=Sply PE=2 SV=1
Length = 545
Score = 395 bits (1014), Expect = 9e-109
Identities = 207/487 (42%), Positives = 296/487 (60%), Gaps = 22/487 (4%)
Frame = +2
Query: 959 FFKKIPGVQSYIDAEKQKVVDQLQSGGNSKKNN----WAKELPVRGLGVQVLEKMESE-- 1120
F KKIP V+ ++ E K + ++ KK+N +++ LP +GL + + ++ E
Sbjct: 64 FAKKIPAVRRQVETELAKAKNDFET--EIKKSNAHLTYSETLPEKGLSKEEILRLVDEHL 121
Query: 1121 KRNDPTWQ-GKCSGTVYIGGSESEGHFTLINQACSMFAHTNPLHIDVFQSVVRFESEVVA 1297
K W+ G+ SG VY L+ + ++TNPLH D+F V + E+EVV
Sbjct: 122 KTGHYNWRDGRVSGAVY---GYKPDLVELVTEVYGKASYTNPLHADLFPGVCKMEAEVVR 178
Query: 1298 MTAALLGSKEAVSGEEICGNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSA 1477
M L A CG MT+GGTESIV+A+K+ RD+ + KGI RP +++P++ H+A
Sbjct: 179 MACNLFHGNSA-----SCGTMTTGGTESIVMAMKAYRDFAREYKGITRPNIVVPKTVHAA 233
Query: 1478 YDKAAQYFNIKLWRVPVGKD-FRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQ 1654
+DK QYFNI + V V + + D+K +R INRNTI++VGSAP FP+G ID IE +
Sbjct: 234 FDKGGQYFNIHVRSVDVDPETYEVDIKKFKRAINRNTILLVGSAPNFPYGTIDDIEAIAA 293
Query: 1655 LAFSYGICFHVDLCLGGFVLPFARKLGYEIPAFDFSVKGVTSISVDVHKYGLAPKGTSTV 1834
L Y I HVD CLG FV+ R GY++ FDF VKGVTSIS D HKYG APKG+S +
Sbjct: 294 LGVKYDIPVHVDACLGSFVVALVRNAGYKLRPFDFEVKGVTSISADTHKYGFAPKGSSVI 353
Query: 1835 LYRNHEIRKHQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIM 2014
LY + + + HQF T+W GG+Y SPT+ GSR G ++A WA MMS G +GYLE T +I+
Sbjct: 354 LYSDKKYKDHQFTVTTDWPGGVYGSPTVNGSRAGGIIAACWATMMSFGYDGYLEATKRIV 413
Query: 2015 EASKRLEEGVRGISELFVVGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIH 2194
+ ++ +E GVR I +F+ GKP +++A GS DIF ++D + GW+LNALQ P+ IH
Sbjct: 414 DTARYIERGVRDIDGIFIFGKPATSVIALGSNVFDIFRLSDSLCKLGWNLNALQFPSGIH 473
Query: 2195 ICVTLQHVP--VVDDFLQDLREAVETVKANPG-PITGGLAPIYGAAGKMPDRGMVNELLV 2365
+CVT H V D F+ D+R + +PG P+ G +A +YG A +PDR ++ E+
Sbjct: 474 LCVTDMHTQPGVADKFIADVRSCTAEIMKDPGQPVVGKMA-LYGMAQSIPDRSVIGEVTR 532
Query: 2366 SFMDSQY 2386
F+ S Y
Sbjct: 533 LFLHSMY 539
>sp|Q05567|SGPL_YEAST Sphingosine-1-phosphate lyase OS=Saccharomyces cerevisiae
GN=DPL1 PE=1 SV=1
Length = 589
Score = 359 bits (920), Expect = 7e-098
Identities = 192/478 (40%), Positives = 290/478 (60%), Gaps = 18/478 (3%)
Frame = +2
Query: 980 VQSYIDAEKQKVVDQLQSGGNSKKNNWAKELPVRGLG----VQVLEKMESEKRNDPTWQG 1147
V+ + KQ + D+L + N +LP G+ ++ L K+ + +G
Sbjct: 110 VEKEVTKVKQSIEDELIRSDSQLMN--FPQLPSNGIPQDDVIEELNKLNDLIPHTQWKEG 167
Query: 1148 KCSGTVYIGGSESEGHFTLINQACSMFAHTNPLHIDVFQSVVRFESEVVAMTAALLGSKE 1327
K SG VY GG + L A + N LH DVF +V + ESEVV+M + +
Sbjct: 168 KVSGAVYHGGDDL---IHLQTIAYEKYCVANQLHPDVFPAVRKMESEVVSMVLRMFNAPS 224
Query: 1328 AVSGEEICGNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFNI 1507
CG TSGGTES++LA S++ Y + +GI PE+I P + H+ +DKAA YF +
Sbjct: 225 DTG----CGTTTSGGTESLLLACLSAKMYALHHRGITEPEIIAPVTAHAGFDKAAYYFGM 280
Query: 1508 KLWRVPVG-KDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFH 1684
KL V + ++ D+ +++ IN+NTI++VGSAP FPHGI D IE LG++A Y + H
Sbjct: 281 KLRHVELDPTTYQVDLGKVKKFINKNTILLVGSAPNFPHGIADDIEGLGKIAQKYKLPLH 340
Query: 1685 VDLCLGGFVLPFARKLGYE-IPAFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRK 1861
VD CLG F++ F K GY+ +P DF V GVTSIS D HKYG APKG+S ++YRN ++R
Sbjct: 341 VDSCLGSFIVSFMEKAGYKNLPLLDFRVPGVTSISCDTHKYGFAPKGSSVIMYRNSDLRM 400
Query: 1862 HQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEG 2041
HQ+ W+GGLY SPT+AGSRPG++V G WA M+++GE GY+E+ +I+ A+ + ++
Sbjct: 401 HQYYVNPAWTGGLYGSPTLAGSRPGAIVVGCWATMVNMGENGYIESCQEIVGAAMKFKKY 460
Query: 2042 VR-GISELFVVGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQHV 2218
++ I +L ++G P ++++F SK L+I E++D +S KGWH NALQ+P ++H+ T
Sbjct: 461 IQENIPDLNIMGNPRYSVISFSSKTLNIHELSDRLSKKGWHFNALQKPVALHMAFTRLSA 520
Query: 2219 PVVDDFLQDLREAVETVK--ANPGPITGGLAPIYGAAGKMPDRGMVNELLVSFMDSQY 2386
VVD+ LR V+ +K +N P G + +YG AG + G+ ++L+V F+D+ Y
Sbjct: 521 HVVDEICDILRTTVQELKSESNSKPSPDGTSALYGVAGSVKTAGVADKLIVGFLDALY 578
>sp|Q9Y194|SGPL_CAEEL Sphingosine-1-phosphate lyase OS=Caenorhabditis elegans
GN=spl-1 PE=2 SV=1
Length = 552
Score = 343 bits (878), Expect = 5e-093
Identities = 198/536 (36%), Positives = 303/536 (56%), Gaps = 24/536 (4%)
Frame = +2
Query: 812 LNSRLSEFEPLALVFTPL-ITLFLAQVIGSVLGVVHEKGLKACLVGFIMGFFKKIPGVQS 988
+N RLS ++P+ LV TL +V+ L E + + ++ +K+P V+
Sbjct: 22 INDRLSRYDPVVLVLAAFGGTLVYTKVVH--LYRKSEDPILKRMGAYVFSLLRKLPAVRD 79
Query: 989 YID----AEKQKVVDQLQSGGNSKKNNWAKELPVRGLGVQVLEKMESEKRNDPTWQ---G 1147
I+ AEK K+++ + + K + LP+ L + ++ + + T+ G
Sbjct: 80 KIEKELAAEKPKLIESIHK--DDKDKQFISTLPIAPLSQDSIMELAKKYEDYNTFNIDGG 137
Query: 1148 KCSGTVYIGGSESEGHFTLINQACSMFAHTNPLHIDVFQSVVRFESEVVAMTAALLGSKE 1327
+ SG VY H L+ + +A +NPLH DVF + E+E++ M L E
Sbjct: 138 RVSGAVYT--DRHAEHINLLGKIYEKYAFSNPLHPDVFPGARKMEAELIRMVLNLYNGPE 195
Query: 1328 AVSGEEICGNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFNI 1507
S G++TSGGTESI++A S R+ + GI+ P ++ ++ H+A+DKAA +
Sbjct: 196 DSS-----GSVTSGGTESIIMACFSYRN-RAHSLGIEHPVILACKTAHAAFDKAAHLCGM 249
Query: 1508 KLWRVPVGKDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFHV 1687
+L VPV D R D+K M R I+ N M+VGSAP FP G IDPI E+ +L YGI HV
Sbjct: 250 RLRHVPVDSDNRVDLKEMERLIDSNVCMLVGSAPNFPSGTIDPIPEIAKLGKKYGIPVHV 309
Query: 1688 DLCLGGFVLPFARKLGYEIPAFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQ 1867
D CLGGF++PF GY IP FDF GVTSIS D HKYG PKG+S V+YR+ E+ Q
Sbjct: 310 DACLGGFMIPFMNDAGYLIPVFDFRNPGVTSISCDTHKYGCTPKGSSIVMYRSKELHHFQ 369
Query: 1868 FVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEGVR 2047
+ +V +W GG+Y +PTIAGSR G+ A AWA ++S G + Y+ +I++ ++ L E +
Sbjct: 370 YFSVADWCGGIYATPTIAGSRAGANTAVAWATLLSFGRDEYVRRCAQIVKHTRMLAEKIE 429
Query: 2048 GISELFVVGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQHV--P 2221
I + GK D+++VAF ++I+EV+D M GW+LN LQ P +IHIC+T+
Sbjct: 430 KIKWIKPYGKSDVSLVAFSGNGVNIYEVSDKMMKLGWNLNTLQNPAAIHICLTINQANEE 489
Query: 2222 VVDDFLQDLREAVETVKA-NPGPITGGLAPIYGAAGKMPDRGMVNELLVSFMDSQY 2386
VV+ F DL + E + A G+A +YG A ++P + +V+E++ ++D+ Y
Sbjct: 490 VVNAFAVDLEKICEELAAKGEQKADSGMAAMYGMAAQVP-KSVVDEVIALYIDATY 544
>sp|A5ULW4|MFNA_METS3 L-tyrosine decarboxylase OS=Methanobrevibacter smithii
(strain PS / ATCC 35061 / DSM 861) GN=mfnA PE=3 SV=1
Length = 385
Score = 211 bits (536), Expect = 2e-053
Identities = 121/337 (35%), Positives = 192/337 (56%), Gaps = 16/337 (4%)
Frame = +2
Query: 1256 VFQSVVRFESEVVAMTAALLGSKEAVSGEEICGNMTSGGTESIVLAVKSSRDYMKYKKGI 1435
+F+ E+EV+ LL E GN+ +GGTE+ ++A++++R++ + KGI
Sbjct: 59 LFKGTKYIENEVIKSIGELLSISEPY------GNIVTGGTEANIMAMRAARNHARKYKGI 112
Query: 1436 KRPEMIIPESGHSAYDKAAQYFNIKLWRVPVGKDFRADVKAMRRHINRNTIMIVGSAPGF 1615
K E+IIP+S H ++ KAA N+K+ + ++++ DV +++ +I+ NT+ IV A
Sbjct: 113 KEGEIIIPDSAHFSFKKAADMMNLKIIEAKLDENYKIDVDSVKENISDNTVAIVAIAGTT 172
Query: 1616 PHGIIDPIEELGQLAFSYGICFHVDLCLGGFVLPFARKLGYEIPAFDFSVKGVTSISVDV 1795
G++DPIEEL ++A+ I FHVD GGF +PF RK+GYE P FDFS+ GV SI+VD
Sbjct: 173 ELGLVDPIEELSEIAYENNIYFHVDAAFGGFSIPFLRKIGYEFPPFDFSLPGVCSITVDP 232
Query: 1796 HKYGLAPKGTSTVLYRNHEIRKHQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSL 1975
HK GLAP +L+R E + +AV + TI G+R G+ A +A M L
Sbjct: 233 HKMGLAPIPAGGILFRKKEYL--EVMAVDSPYLTVKTQSTIVGTRSGAASAATYAIMKYL 290
Query: 1976 GEEGYLENTGKIMEASKRLEEGVRGISELFVVGKPDMTIVAFGSKALDIFEVNDIMSSKG 2155
G EGY + G +M+ + +EG+ I VV +P++ IVAF ++ ++ D + G
Sbjct: 291 GNEGYEKLAGNLMDNTHYFKEGLEKIG-YDVVVEPELNIVAFNHPDMEAHDLADKLEDLG 349
Query: 2156 WHLNALQRPNSIHIC----VTLQHVPVVDDFLQDLRE 2254
W ++ + P +I + +T QH + D L DL E
Sbjct: 350 WRVSVAKCPIAIRVVLMNHITKQH---LTDLLDDLTE 383
>sp|Q9UZD5|MFNA_PYRAB L-tyrosine decarboxylase OS=Pyrococcus abyssi GN=mfnA PE=3
SV=1
Length = 384
Score = 200 bits (506), Expect = 7e-050
Identities = 116/303 (38%), Positives = 178/303 (58%), Gaps = 11/303 (3%)
Frame = +2
Query: 1352 GNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFNIKLWRVPVG 1531
G++ SGGTE+ +LAV++ R+ +RPE+I+P+S H ++ KA + +KL +
Sbjct: 88 GHIVSGGTEANILAVRAFRNI----SDAERPELILPKSAHFSFIKAGEMLGVKLVWAELK 143
Query: 1532 KDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFHVDLCLGGFV 1711
+D+ DVK + I+ NTI IVG A G++D I L LA YGI HVD GGFV
Sbjct: 144 QDYAVDVKDVEAKISDNTIGIVGIAGTTGLGVVDDIPALSDLAREYGIPLHVDAAFGGFV 203
Query: 1712 LPFARKLGYEIPAFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQFVAVTEWS 1891
+PFA+ LGY++P FDF +KGV SI++D HK G+AP +++R + K V +
Sbjct: 204 IPFAKSLGYDLPDFDFKLKGVESITIDPHKMGMAPIPAGGIIFRRKKYLKAISVLAPYLA 263
Query: 1892 GGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEGVRGISELFVV 2071
GG TI G+RPG+ V WA + LG EGY E K ME S+ E ++ ++ ++V
Sbjct: 264 GGKVWQATITGTRPGASVLAVWALIKHLGFEGYREIVRKAMELSRWFAEEIKKLNNAWLV 323
Query: 2072 GKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQHV--PVVDDFLQD 2245
+P + IV+F +K ++ +V + +GW ++A + I V + HV +V++FL+D
Sbjct: 324 REPMLNIVSFQTK--NLRKVERELKRRGWGISAHRGYIRI---VFMPHVTKEMVEEFLRD 378
Query: 2246 LRE 2254
LRE
Sbjct: 379 LRE 381
>sp|O58679|MFNA_PYRHO L-tyrosine decarboxylase OS=Pyrococcus horikoshii GN=mfnA
PE=3 SV=1
Length = 383
Score = 198 bits (503), Expect = 2e-049
Identities = 113/303 (37%), Positives = 179/303 (59%), Gaps = 11/303 (3%)
Frame = +2
Query: 1352 GNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFNIKLWRVPVG 1531
G++ SGGTE+ +LAV++ R+ +++PE+I+P+S H ++ KA + +KL +
Sbjct: 87 GHIVSGGTEANILAVRAFRNL----SDVEKPELILPKSAHFSFIKAGEMLGVKLVWAELN 142
Query: 1532 KDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFHVDLCLGGFV 1711
D+ DV+ + I+ NTI IVG A G++D I L LA YGI HVD GGFV
Sbjct: 143 PDYTVDVRDVEAKISDNTIGIVGIAGTTGLGVVDDIPALSDLARDYGIPLHVDAAFGGFV 202
Query: 1712 LPFARKLGYEIPAFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQFVAVTEWS 1891
+PFA++LGYE+P FDF +KGV SI++D HK G+AP +++R + K V +
Sbjct: 203 IPFAKELGYELPDFDFKLKGVQSITIDPHKMGMAPIPAGGIVFRRKKYLKAISVLAPYLA 262
Query: 1892 GGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEGVRGISELFVV 2071
GG TI G+RPG+ V WA + LG EGY+ + M+ S+ E ++ I+ ++V
Sbjct: 263 GGKVWQATITGTRPGASVIAVWALIKHLGFEGYMRIVERAMKLSRWFAEEIKKINNAWLV 322
Query: 2072 GKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQHV--PVVDDFLQD 2245
+P + IV+F +K L +V + S+GW ++A + I V + HV ++++FL+D
Sbjct: 323 REPMLNIVSFQTKNLK--KVERELKSRGWGISAHRGYIRI---VFMPHVTREMIEEFLKD 377
Query: 2246 LRE 2254
L+E
Sbjct: 378 LKE 380
>sp|Q5JJ82|MFNA_PYRKO L-tyrosine decarboxylase OS=Pyrococcus kodakaraensis
GN=mfnA PE=3 SV=1
Length = 384
Score = 196 bits (498), Expect = 6e-049
Identities = 112/303 (36%), Positives = 176/303 (58%), Gaps = 11/303 (3%)
Frame = +2
Query: 1352 GNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFNIKLWRVPVG 1531
G++ SGGTE+ +LAV++ R+ GI++PE+I+PES H ++ KAA+ +KL +
Sbjct: 86 GHIVSGGTEANILAVRAMRNL----AGIEKPELILPESAHFSFIKAAEMLGVKLVWAELN 141
Query: 1532 KDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFHVDLCLGGFV 1711
D+ +VK + + I TI IVG A G++D I L LA YG+ HVD GGFV
Sbjct: 142 DDYTVNVKDVEKKITDRTIGIVGIAGTTGLGVVDDIPALSDLALDYGLPLHVDAAFGGFV 201
Query: 1712 LPFARKLGYEIPAFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQFVAVTEWS 1891
+PFA+ LGYEIP FDF +KGV SI++D HK G+ P +++R + V +
Sbjct: 202 IPFAKALGYEIPDFDFRLKGVKSITIDPHKMGMVPIPAGGIIFREKKFLDSISVLAPYLA 261
Query: 1892 GGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEGVRGISELFVV 2071
GG TI G+RPG+ WA + LG +GY E + ME ++ ++ I ++++
Sbjct: 262 GGKIWQATITGTRPGANALAVWAMIKHLGFDGYKEVVKEKMELARWFASELKKIPGIYLI 321
Query: 2072 GKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQHV--PVVDDFLQD 2245
+P + IV+FGS+ L+ E+ + ++GW ++A + I V + HV +++FL+D
Sbjct: 322 REPVLNIVSFGSEKLE--ELEKELKARGWGVSAHRGYIRI---VVMPHVKREHLEEFLRD 376
Query: 2246 LRE 2254
LRE
Sbjct: 377 LRE 379
>sp|C5A2X8|MFNA_THEGJ L-tyrosine decarboxylase OS=Thermococcus gammatolerans
(strain DSM 15229 / JCM 11827 / EJ3) GN=mfnA PE=3 SV=1
Length = 383
Score = 192 bits (486), Expect = 2e-047
Identities = 109/305 (35%), Positives = 175/305 (57%), Gaps = 11/305 (3%)
Frame = +2
Query: 1352 GNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFNIKLWRVPVG 1531
G++ SGGTE+ +LAV++ R+ G+++PE+I+P+S H ++ KA + +KL +
Sbjct: 86 GHIVSGGTEANILAVRAFRNL----AGVEKPELILPKSAHFSFIKAGEMLGVKLIWAELN 141
Query: 1532 KDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFHVDLCLGGFV 1711
+D+ +V+ + I NTI IVG A G++D I L LA YG+ HVD GGFV
Sbjct: 142 EDYTVNVRDVEEKITDNTIGIVGIAGTTGLGVVDDIPALSDLALDYGLPLHVDAAFGGFV 201
Query: 1712 LPFARKLGYEIPAFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQFVAVTEWS 1891
+PFA+ LGY+IP FDF +KGV SI++D HK G+ P +++R + + +
Sbjct: 202 IPFAKALGYDIPDFDFRLKGVKSITIDPHKMGMVPIPAGGIIFRERKYIDAISILAPYLA 261
Query: 1892 GGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEGVRGISELFVV 2071
GG TI G+RPG+ WA + LG EGY E K ME S+ ++ I ++++
Sbjct: 262 GGRIWQATITGTRPGANALAVWAMIKHLGFEGYKEIVRKAMELSQWFAGELKKIPGVYLI 321
Query: 2072 GKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQHV--PVVDDFLQD 2245
+P + IV+FG++ L+ V + + +GW ++A + I V + HV +++FL+D
Sbjct: 322 REPVLNIVSFGTENLE--RVEEELKRRGWGISAHRGYIRI---VMMPHVRREHLEEFLRD 376
Query: 2246 LREAV 2260
L E V
Sbjct: 377 LEEIV 381
>sp|Q8U1P6|MFNA_PYRFU L-tyrosine decarboxylase OS=Pyrococcus furiosus GN=mfnA
PE=3 SV=1
Length = 371
Score = 189 bits (479), Expect = 1e-046
Identities = 102/273 (37%), Positives = 161/273 (58%), Gaps = 6/273 (2%)
Frame = +2
Query: 1352 GNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFNIKLWRVPVG 1531
G++ SGGTE+ +LAV++ R+ ++ PE+I+P+S H ++ KA + +KL +
Sbjct: 87 GHIVSGGTEANILAVRAFRNL----ADVENPELILPKSAHFSFIKAGEMLGVKLIWADLN 142
Query: 1532 KDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFHVDLCLGGFV 1711
D+ DVK + I+ NTI IVG A G++D I L LA YGI HVD GGFV
Sbjct: 143 PDYTVDVKDVEAKISENTIGIVGIAGTTGLGVVDDIPALSDLARDYGIPLHVDAAFGGFV 202
Query: 1712 LPFARKLGYEIPAFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQFVAVTEWS 1891
+PFA++LGY++P FDF +KGV SI++D HK G+AP +++R+ + + V +
Sbjct: 203 IPFAKELGYDLPDFDFKLKGVQSITIDPHKMGMAPIPAGGIVFRHKKYLRAISVLAPYLA 262
Query: 1892 GGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEGVRGISELFVV 2071
GG TI G+RPG+ V WA + LG EGY+E + M+ S+ E ++ ++V
Sbjct: 263 GGKIWQATITGTRPGASVLAVWALIKHLGFEGYMEIVDRAMKLSRWFAEEIKKTPGAWLV 322
Query: 2072 GKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNA 2170
+P + IV+F +K ++ V + S+GW ++A
Sbjct: 323 REPMLNIVSFKTK--NLRRVERELKSRGWGISA 353
>sp|O27188|MFNA_METTH L-tyrosine decarboxylase OS=Methanobacterium
thermoautotrophicum GN=mfnA PE=3 SV=1
Length = 363
Score = 187 bits (474), Expect = 4e-046
Identities = 102/301 (33%), Positives = 175/301 (58%), Gaps = 14/301 (4%)
Frame = +2
Query: 1325 EAVSGEEICGNMTSGGTESIVLAVKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFN 1504
E +S + G++ +GGTE+ ++A++++R+ G ++PE+I+P+S H ++ KAA
Sbjct: 54 ELLSEPDAAGHIITGGTEANLMAMRAARN----MAGAEKPEIIVPKSAHFSFRKAADILG 109
Query: 1505 IKLWRVPVGKDFRADVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFH 1684
++L + +D+R DV+++R+ I+ NT+ +VG A G IDP+EEL ++ I H
Sbjct: 110 LRLREAELDQDYRVDVESVRKLISENTVAVVGVAGTTELGRIDPVEELSEICLDEDIHLH 169
Query: 1685 VDLCLGGFVLPFARKLGYEIPAFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKH 1864
+D GGF++PF R+ G E+P FDF ++GV+SI+VD HK GLAP + +L+R+
Sbjct: 170 IDAAFGGFIIPFLRETGAELPEFDFKLQGVSSITVDPHKMGLAPIPSGCILFRDASYLDA 229
Query: 1865 QFVA---VTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLE 2035
+ +TE TI G+R G+ A WA M +G EGY + ++M ++RL
Sbjct: 230 MSIETPYLTEKQ-----QSTIVGTRTGASAAATWAIMKHMGREGYRKLALRVMGVTRRLR 284
Query: 2036 EGVRGISELFVVGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQH 2215
+G+ + VV +P++ IVAF A+ E+ D + GW ++ P +I + V + H
Sbjct: 285 DGLVELDYQLVV-EPELNIVAFNHPAMGPHELADRLEELGWAVSVSSCPPAIRV-VLMPH 342
Query: 2216 V 2218
+
Sbjct: 343 I 343
>sp|Q8PXA5|MFNA_METMA L-tyrosine decarboxylase OS=Methanosarcina mazei GN=mfnA
PE=3 SV=1
Length = 398
Score = 161 bits (407), Expect = 2e-038
Identities = 114/359 (31%), Positives = 182/359 (50%), Gaps = 21/359 (5%)
Frame = +2
Query: 1211 QACSMFAHTNPLHIDVFQSVVRFESEVVAMTAALL--GSKEAVSG----EEICGNMTSGG 1372
+A +F N + +F + E EVV M LL S + SG +CG +T+GG
Sbjct: 42 EANRLFIEANLGDLGLFAGAHKLEQEVVRMLGNLLHASSIDVPSGGLCQSSVCGYLTTGG 101
Query: 1373 TESIVLAVKSSRDYMKY-KKGIK-RPEMIIPESGHSAYDKAAQYFNIKLWRVPVGKDFRA 1546
TES + AV+ ++ + KK K P ++IP S H ++DK A I++ R + +FR
Sbjct: 102 TESNIQAVRGMKNLVTAGKKEFKGTPNIVIPASAHFSFDKVADMMGIEVRRASLDSEFRV 161
Query: 1547 DVKAMRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFHVDLCLGGFVLPFAR 1726
D+ ++ + IN NTI +VG A G IDPI++L ++A + HVD GGFV+PF
Sbjct: 162 DMASVEKLINENTIGLVGIAGNTEFGQIDPIDKLSEVALENELFLHVDAAFGGFVIPFLE 221
Query: 1727 KLGYEIPAFDFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQFVAVTEWSGGLYV 1906
K FDF V GVTSI++D HK GL+ + +L+R+ V+ +
Sbjct: 222 K----PQPFDFKVPGVTSIAIDPHKMGLSTIPSGALLFRSPSFLDSLKVSTPYLTTKSQF 277
Query: 1907 SPTIAGSRPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEGVR--GISELFVVGKP 2080
T+ G+R G+ A A M LG EGY +N ME + ++ E R G L +P
Sbjct: 278 --TLTGTRSGASAAATCAVMKYLGYEGYRKNVQYCMELTSKIVEEARKLGFEPLI---EP 332
Query: 2081 DMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQHVPV-VDDFLQDLRE 2254
M +VA D+ ++ GW+++ + P ++ + + + P ++ FL+DL++
Sbjct: 333 VMNVVALKVPNPDLVR-ERLLKKFGWNVSITRTPRALRLVLMPHNSPEDIELFLEDLKK 390
>sp|Q12VA2|MFNA_METBU L-tyrosine decarboxylase OS=Methanococcoides burtonii
(strain DSM 6242) GN=mfnA PE=3 SV=1
Length = 379
Score = 154 bits (389), Expect = 3e-036
Identities = 102/337 (30%), Positives = 176/337 (52%), Gaps = 19/337 (5%)
Frame = +2
Query: 1214 ACSMFAHTNPLHIDVFQSVVRFESEVVAMTAALLGSKEAVSGEEICGNMTSGGTESIVLA 1393
A + F +N +F E +V+AM +L K + E G +T+GGTES + A
Sbjct: 43 AHTQFIESNMGDPGLFPGTFNLEKQVLAMFGKMLHHK---NSPEKAGYLTTGGTESNIQA 99
Query: 1394 VKSSRDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFNIKLWRVPVGKDFRADVKAMRRHI 1573
++S + ++ I RP +++PES H ++DK A I++ + + K + D+ ++R I
Sbjct: 100 IRSMHN---FRHDISRPNIVMPESAHFSFDKVANLSGIEIRKASLDKLLKVDLDSVRSLI 156
Query: 1574 NRNTIMIVGSAPGFPHGIIDPIEELGQLAFSYGICFHVDLCLGGFVLPFARKLGYEIPAF 1753
++NTI +VG A G +DPI EL ++A GI H+D GGFV+PF + Y +
Sbjct: 157 DKNTIGLVGIAGTTEFGQLDPINELSKIAIEKGIFLHIDAAFGGFVIPF-MDIDY---TY 212
Query: 1754 DFSVKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQFVAVTEWSGGLYVSP--TIAGS 1927
DF ++GVTS+++D HK L+ + +L++ E F + + L V+ ++ G+
Sbjct: 213 DFRLEGVTSMTIDPHKMALSTIPSGGLLFKEPE----YFECLEIHTPYLSVNKQYSLTGT 268
Query: 1928 RPGSLVAGAWAAMMSLGEEGYLENTGKIMEASKRLEEGVRGISELFVVGKPDMTIVAFGS 2107
R G+ VA +A M LG +GY + M +K+L +G + + V P + IVA
Sbjct: 269 RSGAGVASTYAVMKHLGRKGYKKVVSDCMSVTKKLVDGAEKLG-INTVIDPVLNIVALDV 327
Query: 2108 KALDIFEVNDIMSSKGWHLNALQRPNSIHICVTLQHV 2218
D+ ++ GWH++ + P ++ I V + H+
Sbjct: 328 PEADLVR-KKLLDEYGWHVSITRNPRALRI-VIMPHI 362
>sp|Q0W498|MFNA_UNCMA L-tyrosine decarboxylase OS=Uncultured methanogenic
archaeon RC-I GN=mfnA PE=3 SV=1
Length = 375
Score = 145 bits (365), Expect = 2e-033
Identities = 103/332 (31%), Positives = 171/332 (51%), Gaps = 20/332 (6%)
Frame = +2
Query: 1226 FAHTNPLHIDVFQSVVRFESEVVAMTAALLGSKEAVSGEEICGNMTSGGTESIVLAVKSS 1405
F +TN +F E + + LL A G +++GGTES + A++++
Sbjct: 47 FVNTNLGDPKLFPGTADIEHRCIGLIGDLLHLPAAT------GYISTGGTESNIQALRTA 100
Query: 1406 RDYMKYKKGIKRPEMIIPESGHSAYDKAAQYFNIKLWRVPVGKDFRADVKAMRRHINRNT 1585
MK+ +R +++PES H +++KA+Q I + R P+ RAD M I++NT
Sbjct: 101 IQ-MKHTDR-RRANIVVPESAHYSFEKASQMLGIAIRRAPLDDLLRADPSEMAALIDKNT 158
Query: 1586 IMIVGSAPGFPHGIIDPIEELGQLAFSYGICFHVDLCLGGFVLPFARKLGYEIPA-FDFS 1762
I +V A G IDPIEE+G+LA + + HVD GGFV+PF + PA FDF
Sbjct: 159 IALVAVAGTTEFGQIDPIEEIGRLAQEHDLYLHVDAAFGGFVIPFMDR-----PAKFDFE 213
Query: 1763 VKGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQFVAVTEWSGGLYVSPTIAGSRPGSL 1942
+ GV SI++D HK GL+ + +LYR+ + K + + V ++AG+R G+
Sbjct: 214 IPGVQSITIDPHKMGLSTIPSGGLLYRSESLMK--VLEINAQYLTSMVQTSLAGTRSGAS 271
Query: 1943 VAGAWAAMMSLGEEGYLENTGKIMEASKRLEEGVRGISELFVVGKPDMTIVAFGSKALDI 2122
A A+A + LG GY E ME ++ L E + + ++ +P + IV ++A D
Sbjct: 272 AASAYAVLQYLGRAGYREIVATCMENTRILREQLEDMGMEPII-EPVLNIVT--ARAKDP 328
Query: 2123 FEVNDIMSSKGWHLNALQRPNSIHICVTLQHV 2218
+ ++ K W+++ P ++ + V + HV
Sbjct: 329 VGLRKKLAEKNWYVSTTVHPCALRM-VVMPHV 359
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,378,909,851
Number of Sequences: 518415
Number of Extensions: 78378909851
Number of Successful Extensions: 523441567
Number of sequences better than 0.0: 0
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