BLASTX 7.6.2
Query= UN18947 /QuerySize=1568
(1567 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabi... 272 7e-072
sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase D... 203 3e-051
sp|Q55A09|Y9963_DICDI Probable serine/threonine-protein kinase D... 186 6e-046
sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kin... 181 1e-044
sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase ki... 179 8e-044
sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase ki... 178 1e-043
sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kina... 178 1e-043
sp|A7J1T0|M313B_XENLA Mitogen-activated protein kinase kinase ki... 175 8e-043
sp|A7J1T2|M313A_XENLA Mitogen-activated protein kinase kinase ki... 171 1e-041
sp|O43283|M3K13_HUMAN Mitogen-activated protein kinase kinase ki... 171 2e-041
sp|Q1HKZ5|M3K13_MOUSE Mitogen-activated protein kinase kinase ki... 171 2e-041
sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kin... 167 3e-040
sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kin... 166 5e-040
sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase ki... 163 3e-039
sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase ki... 163 3e-039
sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kina... 163 6e-039
sp|Q54L00|LIMKA_DICDI Probable LIM domain-containing serine/thre... 159 5e-038
sp|Q54I36|PYK3_DICDI Dual specificity protein kinase pyk3 OS=Dic... 159 5e-038
sp|P0CD62|LIMKB_DICDI Probable LIM domain-containing serine/thre... 158 2e-037
sp|Q54TA1|DRKC_DICDI Probable serine/threonine-protein kinase dr... 149 8e-035
>sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabidopsis thaliana
GN=HT1 PE=1 SV=1
Length = 390
Score = 272 bits (694), Expect = 7e-072
Identities = 127/266 (47%), Positives = 182/266 (68%), Gaps = 1/266 (0%)
Frame = -3
Query: 1082 DEWTIDLRKLHMGPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQL-MGQQFQQEV 906
+EWT DL +L +G A GA ++YRG Y VA+K++ P E+ + + QQF+ EV
Sbjct: 77 EEWTADLSQLFIGNKFASGAHSRIYRGIYKQRAVAVKMVRIPTHKEETRAKLEQQFKSEV 136
Query: 905 MMLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQALDV 726
+L+ L H NIV+FI AC++ V+CI+TEY G+LR +L K++ ++ ++ ++ ALD+
Sbjct: 137 ALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDI 196
Query: 725 ATGMAYVHGLGYIHRDLKSDNLLISADRSIKIADFGVARIEVKTEGMTPETGTYRWMAPE 546
+ GM Y+H G IHRDLKS+NLL++ + +K+ADFG + +E + GTYRWMAPE
Sbjct: 197 SRGMEYLHSQGVIHRDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGNMGTYRWMAPE 256
Query: 545 MIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCLPVLR 366
MI+ +PYT+KVDVYSFGIVLWEL T ++PFQ MT VQAAFAV + RP +P C P L
Sbjct: 257 MIKEKPYTRKVDVYSFGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALA 316
Query: 365 NILTRCWDADPEVRPPFTEIVMMLER 288
+++ RCW +P RP F+ IV +LE+
Sbjct: 317 HLIKRCWSENPSKRPDFSNIVAVLEK 342
>sp|Q55GU0|Y9955_DICDI Probable serine/threonine-protein kinase DDB_G0267514
OS=Dictyostelium discoideum GN=DDB_G0267514 PE=3 SV=1
Length = 916
Score = 203 bits (516), Expect = 3e-051
Identities = 105/264 (39%), Positives = 162/264 (61%), Gaps = 3/264 (1%)
Frame = -3
Query: 1085 FDEWTIDLRKLHMGPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQLMGQQFQQEV 906
F + I +L + L +G FG +Y+G + G VAIK ++ ED L ++F++E+
Sbjct: 652 FSDIEISFSELKISSKLGEGTFGVVYKGLWRGSSVAIKQIKINEDVNNQVL--EEFRKEL 709
Query: 905 MMLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQALDV 726
+L+ L+H NIV + AC C +TEY GGSL L ++ + + ++L K A+ +
Sbjct: 710 TILSRLRHPNIVLLMAACTAPPNLCFITEYLPGGSLYDALHSKKIK-MNMQLYKKLAIQI 768
Query: 725 ATGMAYVHGLGYIHRDLKSDNLLISADRSIKIADFGVARIEVKTEGMTPETGTYRWMAPE 546
A GM Y+H G IHRD+KS NLL+ ++KI DFG+++++ K+ MT G+ WM+PE
Sbjct: 769 AQGMNYLHLSGVIHRDIKSLNLLLDEHMNVKICDFGLSKLKSKSTEMTKSIGSPIWMSPE 828
Query: 545 MIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCLPVLR 366
++ YT+KVDVY+FGI+LWEL TG +P+ + +VQ A AV + +RP IP+ L
Sbjct: 829 LLMGEDYTEKVDVYAFGIILWELGTGELPYSGLDSVQLALAVTTKSLRPPIPNAWPYQLS 888
Query: 365 NILTRCWDADPEVRPPFTEIVMML 294
+++ CW DP RP FTEI+ +L
Sbjct: 889 HLIQACWHQDPLKRPSFTEILNLL 912
>sp|Q55A09|Y9963_DICDI Probable serine/threonine-protein kinase DDB_G0272254
OS=Dictyostelium discoideum GN=DDB_G0272254 PE=3 SV=1
Length = 1331
Score = 186 bits (470), Expect = 6e-046
Identities = 102/266 (38%), Positives = 155/266 (58%), Gaps = 9/266 (3%)
Frame = -3
Query: 1070 IDLRKLHMGPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQLMGQQFQQEVMMLAT 891
I+ + + + +G F K+ +G + G DVA+K L +D + +++ Q+F+ EV +L +
Sbjct: 1068 INYSDIKIDKEIGKGHFSKVLKGNWKGKDVAVKKLNSNKDKAREEMI-QEFKAEVELLGS 1126
Query: 890 LKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKR---QNRAVPL--KLAVKQALDV 726
L+H N+V G M CIV E+ G+L + + + Q +++ L L + A D+
Sbjct: 1127 LQHPNLVTCYGYSLNPM--CIVMEFLPSGNLFELIHSKPSEQQQSIKLDSTLILAIAFDI 1184
Query: 725 ATGMAYVHGLGYIHRDLKSDNLLISADRSIKIADFGVARIEVKTEGMTPETGTYRWMAPE 546
A GM ++H IHRDLKS NLL+ +IKIAD G+AR T+ MT GT W APE
Sbjct: 1185 ARGMQHLHTRNIIHRDLKSSNLLMDKHFNIKIADLGIARETSFTQTMT-TIGTVAWTAPE 1243
Query: 545 MIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCLPVLR 366
+++H Y QK DVYS+ IVL+ELLTG P+Q + + A V ++G+RP +PD+C P +
Sbjct: 1244 ILRHESYNQKADVYSYAIVLYELLTGEEPYQGIPPMNAGILVASKGLRPELPDNCDPNWK 1303
Query: 365 NILTRCWDADPEVRPPFTEIVMMLER 288
++ CW DP RP F EI L +
Sbjct: 1304 KLVVWCWSEDPNKRPSFEEITNYLTK 1329
>sp|P80192|M3K9_HUMAN Mitogen-activated protein kinase kinase kinase 9 OS=Homo
sapiens GN=MAP3K9 PE=1 SV=3
Length = 1104
Score = 181 bits (459), Expect = 1e-044
Identities = 103/288 (35%), Positives = 157/288 (54%), Gaps = 16/288 (5%)
Frame = -3
Query: 1070 IDLRKLHMGPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQLMGQQFQQEVMMLAT 891
ID +L + + G FGK+YR + GD+VA+K D + +Q + + +QE + A
Sbjct: 139 IDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTI-ENVRQEAKLFAM 197
Query: 890 LKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQALDVATGMA 711
LKH NI+ G C + C+V E+A+GG L + L+ + +P + V A+ +A GM
Sbjct: 198 LKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLS---GKRIPPDILVNWAVQIARGMN 254
Query: 710 YVHG---LGYIHRDLKSDNLLI--------SADRSIKIADFGVARIEVKTEGMTPETGTY 564
Y+H + IHRDLKS N+LI +++ +KI DFG+AR +T M+ GTY
Sbjct: 255 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMS-AAGTY 313
Query: 563 RWMAPEMIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDD 384
WMAPE+I+ +++ DV+S+G++LWELLTG VPF+ + + A+ V + IP
Sbjct: 314 AWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPST 373
Query: 383 CLPVLRNILTRCWDADPEVRPPFTEIVMMLERAEAEVMNNVRKARFRC 240
C ++ CW+ DP RP FT I+ L E + K F C
Sbjct: 374 CPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHC 421
>sp|Q16584|M3K11_HUMAN Mitogen-activated protein kinase kinase kinase 11 OS=Homo
sapiens GN=MAP3K11 PE=1 SV=1
Length = 847
Score = 179 bits (452), Expect = 8e-044
Identities = 104/283 (36%), Positives = 155/283 (54%), Gaps = 16/283 (5%)
Frame = -3
Query: 1061 RKLHMGPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQLMGQQFQQEVMMLATLKH 882
++L + + G FGK+YRG++ G+ VA+K + D E + + +QE + A L H
Sbjct: 115 QELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPD-EDISVTAESVRQEARLFAMLAH 173
Query: 881 ANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQALDVATGMAYVH 702
NI+ C C+V EYA GG L + L R VP + V A+ +A GM Y+H
Sbjct: 174 PNIIALKAVCLEEPNLCLVMEYAAGGPLSRALA---GRRVPPHVLVNWAVQIARGMHYLH 230
Query: 701 G---LGYIHRDLKSDNLL----ISAD----RSIKIADFGVARIEVKTEGMTPETGTYRWM 555
+ IHRDLKS+N+L I +D +++KI DFG+AR KT M+ GTY WM
Sbjct: 231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMS-AAGTYAWM 289
Query: 554 APEMIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCLP 375
APE+I+ +++ DV+SFG++LWELLTG VP++ + + A+ V + IP C
Sbjct: 290 APEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPE 349
Query: 374 VLRNILTRCWDADPEVRPPFTEIVMMLERAEAEVMNNVRKARF 246
++ CW DP RP F I+ LE EA+V+ + + F
Sbjct: 350 PFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSF 392
>sp|Q80XI6|M3K11_MOUSE Mitogen-activated protein kinase kinase kinase 11 OS=Mus
musculus GN=Map3k11 PE=1 SV=1
Length = 850
Score = 178 bits (451), Expect = 1e-043
Identities = 102/283 (36%), Positives = 153/283 (54%), Gaps = 16/283 (5%)
Frame = -3
Query: 1061 RKLHMGPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQLMGQQFQQEVMMLATLKH 882
++L + + G FGK+YRG++ G+ VA+K + D E + + +QE + A L H
Sbjct: 116 QELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPD-EDISVTAESVRQEARLFAMLAH 174
Query: 881 ANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQALDVATGMAYVH 702
NI+ C C+V EYA GG L + L R VP + V A+ +A GM Y+H
Sbjct: 175 PNIIALKAVCLEEPNLCLVMEYAAGGPLSRALA---GRRVPPHVLVNWAVQIARGMHYLH 231
Query: 701 G---LGYIHRDLKSDNLLI--------SADRSIKIADFGVARIEVKTEGMTPETGTYRWM 555
+ IHRDLKS+N+L+ +++KI DFG+AR KT M+ GTY WM
Sbjct: 232 CEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMS-AAGTYAWM 290
Query: 554 APEMIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCLP 375
APE+I+ +++ DV+SFG++LWELLTG VP++ + + A+ V + IP C
Sbjct: 291 APEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPE 350
Query: 374 VLRNILTRCWDADPEVRPPFTEIVMMLERAEAEVMNNVRKARF 246
++ CW DP RP F I+ LE EA+V+ + + F
Sbjct: 351 PFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSF 393
>sp|Q66HA1|M3K11_RAT Mitogen-activated protein kinase kinase kinase 11 OS=Rattus
norvegicus GN=Map3k11 PE=2 SV=1
Length = 850
Score = 178 bits (451), Expect = 1e-043
Identities = 102/283 (36%), Positives = 153/283 (54%), Gaps = 16/283 (5%)
Frame = -3
Query: 1061 RKLHMGPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQLMGQQFQQEVMMLATLKH 882
++L + + G FGK+YRG++ G+ VA+K + D E + + +QE + A L H
Sbjct: 116 QELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPD-EDISVTAESVRQEARLFAMLAH 174
Query: 881 ANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQALDVATGMAYVH 702
NI+ C C+V EYA GG L + L R VP + V A+ +A GM Y+H
Sbjct: 175 PNIIALKAVCLEEPNLCLVMEYAAGGPLSRALA---GRRVPPHVLVNWAVQIARGMHYLH 231
Query: 701 G---LGYIHRDLKSDNLLI--------SADRSIKIADFGVARIEVKTEGMTPETGTYRWM 555
+ IHRDLKS+N+L+ +++KI DFG+AR KT M+ GTY WM
Sbjct: 232 CEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMS-AAGTYAWM 290
Query: 554 APEMIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCLP 375
APE+I+ +++ DV+SFG++LWELLTG VP++ + + A+ V + IP C
Sbjct: 291 APEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPE 350
Query: 374 VLRNILTRCWDADPEVRPPFTEIVMMLERAEAEVMNNVRKARF 246
++ CW DP RP F I+ LE EA+V+ + + F
Sbjct: 351 PFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSF 393
>sp|A7J1T0|M313B_XENLA Mitogen-activated protein kinase kinase kinase 13-B
OS=Xenopus laevis GN=map3k13-b PE=2 SV=1
Length = 961
Score = 175 bits (443), Expect = 8e-043
Identities = 98/302 (32%), Positives = 165/302 (54%), Gaps = 20/302 (6%)
Frame = -3
Query: 1082 DEWTIDLRKLHMGPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQLMGQQFQQEVM 903
D W + ++ L GA G ++ G + G++VAIK + +Q + ++
Sbjct: 162 DTWEVPFEEISELQWLGSGAQGAVFLGKFRGEEVAIKKVR------------EQKETDIK 209
Query: 902 MLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQALDVA 723
L LKH NI+ F G C ++ +CI+ EY G L + L R R V KL V+ + +A
Sbjct: 210 HLRKLKHPNIIAFKGVCTQAPCYCILMEYCAQGQLYEVL--RAGRKVTPKLLVEWSTGIA 267
Query: 722 TGMAYVHGLGYIHRDLKSDNLLISADRSIKIADFGVARIEVKTEGMTPETGTYRWMAPEM 543
+GM Y+H IHRDLKS N+L++ ++KI+DFG ++ GT WMAPE+
Sbjct: 268 SGMNYLHLHKIIHRDLKSPNVLVTHADTVKISDFGTSKELSDKSTKMSFAGTVAWMAPEV 327
Query: 542 IQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCLPVLRN 363
I++ P ++KVD++SFG++LWELLTG +P++++ + + V + + +P C +
Sbjct: 328 IRNEPVSEKVDIWSFGVLLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 387
Query: 362 ILTRCWDADPEVRPPFTEIVMMLERAEAEVMNNVRKARFRCCAQPMTID*VRETRQKHRK 183
++ + W + P RP F +I+M L+ A A+V+ ++ F+ A+ RE +KH +
Sbjct: 388 LMKQTWQSKPRNRPSFRQILMHLDIAAADVLGTPQETYFKSQAE------WREEVKKHFE 441
Query: 182 NI 177
I
Sbjct: 442 KI 443
>sp|A7J1T2|M313A_XENLA Mitogen-activated protein kinase kinase kinase 13-A
OS=Xenopus laevis GN=map3k13-a PE=2 SV=1
Length = 961
Score = 171 bits (433), Expect = 1e-041
Identities = 95/302 (31%), Positives = 164/302 (54%), Gaps = 20/302 (6%)
Frame = -3
Query: 1082 DEWTIDLRKLHMGPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQLMGQQFQQEVM 903
+ W + ++ L GA G ++ G + G++VAIK + +Q + ++
Sbjct: 160 ETWEVPFEEISELQWLGSGAQGAVFLGKFRGEEVAIKKVR------------EQKETDIK 207
Query: 902 MLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQALDVA 723
L LKH NI+ F G C ++ +C++ EY G L + L R R V +L V + +A
Sbjct: 208 HLRKLKHPNIIAFKGVCTQAPCYCLIMEYCAHGQLYEVL--RAGRKVSPRLLVDWSNGIA 265
Query: 722 TGMAYVHGLGYIHRDLKSDNLLISADRSIKIADFGVARIEVKTEGMTPETGTYRWMAPEM 543
+GM Y+H IHRDLKS N+L++ ++KI+DFG ++ GT WMAPE+
Sbjct: 266 SGMNYLHLHKIIHRDLKSPNVLVTHTDTVKISDFGTSKELSDKSTKMSFAGTVAWMAPEV 325
Query: 542 IQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCLPVLRN 363
I++ P ++KVD++SFG++LWELLTG +P++++ + + V + + +P C +
Sbjct: 326 IRNEPVSEKVDIWSFGVLLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 385
Query: 362 ILTRCWDADPEVRPPFTEIVMMLERAEAEVMNNVRKARFRCCAQPMTID*VRETRQKHRK 183
++ + W + P RP F +I+M L+ A A+V+ ++ F+ A+ RE +KH +
Sbjct: 386 LMKQTWHSKPRNRPSFRQILMHLDIASADVLGTPQETYFKSQAE------WREEVKKHFE 439
Query: 182 NI 177
I
Sbjct: 440 KI 441
>sp|O43283|M3K13_HUMAN Mitogen-activated protein kinase kinase kinase 13 OS=Homo
sapiens GN=MAP3K13 PE=1 SV=1
Length = 966
Score = 171 bits (431), Expect = 2e-041
Identities = 95/302 (31%), Positives = 162/302 (53%), Gaps = 20/302 (6%)
Frame = -3
Query: 1082 DEWTIDLRKLHMGPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQLMGQQFQQEVM 903
D W + ++ L GA G ++ G + ++VAIK + +Q + ++
Sbjct: 159 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVR------------EQNETDIK 206
Query: 902 MLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQALDVA 723
L LKH NI+ F G C ++ +CI+ EY G L + L R R + +L V + +A
Sbjct: 207 HLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL--RAGRKITPRLLVDWSTGIA 264
Query: 722 TGMAYVHGLGYIHRDLKSDNLLISADRSIKIADFGVARIEVKTEGMTPETGTYRWMAPEM 543
+GM Y+H IHRDLKS N+L++ ++KI+DFG ++ GT WMAPE+
Sbjct: 265 SGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEV 324
Query: 542 IQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCLPVLRN 363
I++ P ++KVD++SFG+VLWELLTG +P++++ + + V + + +P C +
Sbjct: 325 IRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 384
Query: 362 ILTRCWDADPEVRPPFTEIVMMLERAEAEVMNNVRKARFRCCAQPMTID*VRETRQKHRK 183
++ + W + P RP F + +M L+ A A+V+ ++ F+ A+ RE +KH +
Sbjct: 385 LMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAE------WREEVKKHFE 438
Query: 182 NI 177
I
Sbjct: 439 KI 440
>sp|Q1HKZ5|M3K13_MOUSE Mitogen-activated protein kinase kinase kinase 13 OS=Mus
musculus GN=Map3k13 PE=2 SV=1
Length = 959
Score = 171 bits (431), Expect = 2e-041
Identities = 95/302 (31%), Positives = 162/302 (53%), Gaps = 20/302 (6%)
Frame = -3
Query: 1082 DEWTIDLRKLHMGPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQLMGQQFQQEVM 903
D W + ++ L GA G ++ G + ++VAIK + +Q + ++
Sbjct: 158 DTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVR------------EQNETDIK 205
Query: 902 MLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQALDVA 723
L LKH NI+ F G C ++ +CI+ EY G L + L R R + +L V + +A
Sbjct: 206 HLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVL--RAGRKITPRLLVDWSTGIA 263
Query: 722 TGMAYVHGLGYIHRDLKSDNLLISADRSIKIADFGVARIEVKTEGMTPETGTYRWMAPEM 543
+GM Y+H IHRDLKS N+L++ ++KI+DFG ++ GT WMAPE+
Sbjct: 264 SGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEV 323
Query: 542 IQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCLPVLRN 363
I++ P ++KVD++SFG+VLWELLTG +P++++ + + V + + +P C +
Sbjct: 324 IRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKI 383
Query: 362 ILTRCWDADPEVRPPFTEIVMMLERAEAEVMNNVRKARFRCCAQPMTID*VRETRQKHRK 183
++ + W + P RP F + +M L+ A A+V+ ++ F+ A+ RE +KH +
Sbjct: 384 LMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAE------WREEVKKHFE 437
Query: 182 NI 177
I
Sbjct: 438 KI 439
>sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kinase MLT OS=Mus
musculus GN=Mltk PE=1 SV=1
Length = 802
Score = 167 bits (421), Expect = 3e-040
Identities = 89/225 (39%), Positives = 134/225 (59%), Gaps = 4/225 (1%)
Frame = -3
Query: 956 EDPEKAQLMGQQFQQEVMMLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKR 777
+D E A + ++E +L+ L H NI++F G + IVTEYA GSL ++
Sbjct: 38 QDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSN 97
Query: 776 QNRAVPLKLAVKQALDVATGMAYVH---GLGYIHRDLKSDNLLISADRSIKIADFGVARI 606
++ + ++ + A DVA GM Y+H + IHRDLKS N++I+AD +KI DFG +R
Sbjct: 98 RSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF 157
Query: 605 EVKTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAF 426
T M+ GT+ WMAPE+IQ P ++ D YS+G+VLWE+LT VPF+ + +Q A+
Sbjct: 158 HNHTTHMS-LVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAW 216
Query: 425 AVVNRGVRPSIPDDCLPVLRNILTRCWDADPEVRPPFTEIVMMLE 291
VV + R +IP C +L +CW+AD + RP F +I+ +LE
Sbjct: 217 LVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILE 261
>sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kinase MLT OS=Homo
sapiens GN=MLTK PE=1 SV=2
Length = 800
Score = 166 bits (419), Expect = 5e-040
Identities = 89/225 (39%), Positives = 133/225 (59%), Gaps = 4/225 (1%)
Frame = -3
Query: 956 EDPEKAQLMGQQFQQEVMMLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKR 777
+D E A + ++E +L+ L H NI++F G + IVTEYA GSL ++
Sbjct: 38 QDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSN 97
Query: 776 QNRAVPLKLAVKQALDVATGMAYVH---GLGYIHRDLKSDNLLISADRSIKIADFGVARI 606
++ + + + A DVA GM Y+H + IHRDLKS N++I+AD +KI DFG +R
Sbjct: 98 RSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF 157
Query: 605 EVKTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAF 426
T M+ GT+ WMAPE+IQ P ++ D YS+G+VLWE+LT VPF+ + +Q A+
Sbjct: 158 HNHTTHMS-LVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAW 216
Query: 425 AVVNRGVRPSIPDDCLPVLRNILTRCWDADPEVRPPFTEIVMMLE 291
VV + R +IP C +L +CW+AD + RP F +I+ +LE
Sbjct: 217 LVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILE 261
>sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 OS=Homo
sapiens GN=MAP3K12 PE=1 SV=2
Length = 859
Score = 163 bits (412), Expect = 3e-039
Identities = 82/229 (35%), Positives = 136/229 (59%), Gaps = 2/229 (0%)
Frame = -3
Query: 917 QQEVMMLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQ 738
+ ++ L LKH NI+ F G C ++ +CI+ E+ G L + L R R V L V
Sbjct: 159 ETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL--RAGRPVTPSLLVDW 216
Query: 737 ALDVATGMAYVHGLGYIHRDLKSDNLLISADRSIKIADFGVARIEVKTEGMTPETGTYRW 558
++ +A GM Y+H IHRDLKS N+LI+ D +KI+DFG ++ GT W
Sbjct: 217 SMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAW 276
Query: 557 MAPEMIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCL 378
MAPE+I++ P ++KVD++SFG+VLWELLTG +P++++ + + V + + +P C
Sbjct: 277 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCP 336
Query: 377 PVLRNILTRCWDADPEVRPPFTEIVMMLERAEAEVMNNVRKARFRCCAQ 231
+ +L +CW++ P RP F +I++ L+ A A+V++ ++ F+ A+
Sbjct: 337 DGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAE 385
>sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase kinase 12 OS=Mus
musculus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 163 bits (412), Expect = 3e-039
Identities = 82/229 (35%), Positives = 136/229 (59%), Gaps = 2/229 (0%)
Frame = -3
Query: 917 QQEVMMLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQ 738
+ ++ L LKH NI+ F G C ++ +CI+ E+ G L + L R R V L V
Sbjct: 192 ETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL--RAGRPVTPSLLVDW 249
Query: 737 ALDVATGMAYVHGLGYIHRDLKSDNLLISADRSIKIADFGVARIEVKTEGMTPETGTYRW 558
++ +A GM Y+H IHRDLKS N+LI+ D +KI+DFG ++ GT W
Sbjct: 250 SMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAW 309
Query: 557 MAPEMIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCL 378
MAPE+I++ P ++KVD++SFG+VLWELLTG +P++++ + + V + + +P C
Sbjct: 310 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCP 369
Query: 377 PVLRNILTRCWDADPEVRPPFTEIVMMLERAEAEVMNNVRKARFRCCAQ 231
+ +L +CW++ P RP F +I++ L+ A A+V++ ++ F+ A+
Sbjct: 370 DGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAE 418
>sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kinase 12 OS=Rattus
norvegicus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 163 bits (410), Expect = 6e-039
Identities = 82/229 (35%), Positives = 135/229 (58%), Gaps = 2/229 (0%)
Frame = -3
Query: 917 QQEVMMLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAVKQ 738
+ ++ L LKH NI+ F G C ++ +CI+ E+ G L + L R R V L V
Sbjct: 192 ETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVL--RAGRPVTPSLLVDW 249
Query: 737 ALDVATGMAYVHGLGYIHRDLKSDNLLISADRSIKIADFGVARIEVKTEGMTPETGTYRW 558
++ +A GM Y+H IHRDLKS N+LI+ D +KI+DFG ++ GT W
Sbjct: 250 SMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAW 309
Query: 557 MAPEMIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCL 378
MAPE+I++ P ++KVD++SFG+VLWELLTG +P++++ + + V + + +P C
Sbjct: 310 MAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCP 369
Query: 377 PVLRNILTRCWDADPEVRPPFTEIVMMLERAEAEVMNNVRKARFRCCAQ 231
+ +L +CW+ P RP F +I++ L+ A A+V++ ++ F+ A+
Sbjct: 370 DGFKILLRQCWNRKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAE 418
>sp|Q54L00|LIMKA_DICDI Probable LIM domain-containing serine/threonine-protein
kinase DDB_G0287001 OS=Dictyostelium discoideum GN=DDB_G0287001 PE=3
SV=1
Length = 650
Score = 159 bits (402), Expect = 5e-038
Identities = 94/256 (36%), Positives = 141/256 (55%), Gaps = 9/256 (3%)
Frame = -3
Query: 1046 GPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQLMGQQFQQEV--MMLATLKHANI 873
G +A GA GK+Y+G Y G DVAIK+ E ++F +EV M L H N
Sbjct: 389 GDVIASGASGKVYKGIYKGRDVAIKVY----SSENFCFNIEEFDREVTIMSLIDSDHPNF 444
Query: 872 VRFIGACRRSMVWCI-VTEYAKGGSLRQFLTKRQNRAVPLKLAVKQALDVATGMAYVHGL 696
RF GA +++ + V+E K GSLR L ++ + + + A D+A M ++H +
Sbjct: 445 TRFYGANKQNKKYLFHVSELVKSGSLRDLLLDKE-KPLAYFTQLSIASDIANAMKHLHSI 503
Query: 695 GYIHRDLKSDNLLISADRSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYTQK 516
G IHRDLKS N+LI+ D + K+ DFG +R + MT GT +M+PE+ + Y +
Sbjct: 504 GVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKQMTLNLGTSCYMSPELFKGNGYDET 563
Query: 515 VDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCLPVLRNILTRCWDAD 336
DVY+FGIVLWE++ P++N+ + +V +G RP+IP DC ++ CW
Sbjct: 564 CDVYAFGIVLWEIIARKEPYENINSWSIP-VLVAKGERPTIPADCPSEYSKLIKACWTDK 622
Query: 335 PEVRPPFTEIVMMLER 288
P+ RP F EI L++
Sbjct: 623 PKKRPSFKEICDTLKK 638
>sp|Q54I36|PYK3_DICDI Dual specificity protein kinase pyk3 OS=Dictyostelium
discoideum GN=pyk3 PE=1 SV=1
Length = 1338
Score = 159 bits (402), Expect = 5e-038
Identities = 86/225 (38%), Positives = 133/225 (59%), Gaps = 10/225 (4%)
Frame = -3
Query: 926 QQFQQEVMMLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLA 747
++F +EV L H N+V F+GAC CI TEY +GGSL L ++ + PL +
Sbjct: 1095 EKFIKEVSSLIKSHHPNVVTFMGACIDPP--CIFTEYLQGGSLYDVLHIQKIKLNPL-MM 1151
Query: 746 VKQALDVATGMAYVHGLGYIHRDLKSDNLLISADRSIKIADFGVARI---EVKTEGMTPE 576
K D++ GM ++H + +HRDL S N+L+ ++IKIADFG+A ++ G+T
Sbjct: 1152 YKMIHDLSLGMEHLHSIQMLHRDLTSKNILLDEFKNIKIADFGLATTLSDDMTLSGIT-- 1209
Query: 575 TGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPS 396
RW +PE+ + Y +KVDVYSFG+V++E+ TG +PF+ + +A RP+
Sbjct: 1210 --NPRWRSPELTKGLVYNEKVDVYSFGLVVYEIYTGKIPFEGLDGTASAAKAAFENYRPA 1267
Query: 395 IPDDCLPVLRNILTRCWDADPEVRPPFTEIVMMLERAEAEVMNNV 261
IP DC LR ++T+CW +DP RP FTEI+ LE +++ + +
Sbjct: 1268 IPPDCPVSLRKLITKCWASDPSQRPSFTEILTELETMKSKFIKQL 1312
>sp|P0CD62|LIMKB_DICDI Probable LIM domain-containing serine/threonine-protein
kinase DDB_G0286997 OS=Dictyostelium discoideum GN=DDB_G0286997 PE=3
SV=1
Length = 966
Score = 158 bits (397), Expect = 2e-037
Identities = 94/256 (36%), Positives = 140/256 (54%), Gaps = 9/256 (3%)
Frame = -3
Query: 1046 GPALAQGAFGKLYRGTYNGDDVAIKILERPEDPEKAQLMGQQFQQEV--MMLATLKHANI 873
G +A GA GK+Y+G Y G DVAIK+ E +F +EV M L H N
Sbjct: 705 GDVIAAGASGKVYKGIYKGRDVAIKVY----SSENFCFNIDEFDREVTIMSLIDSDHPNF 760
Query: 872 VRFIGACRRSMVWCI-VTEYAKGGSLRQFLTKRQNRAVPLKLAVKQALDVATGMAYVHGL 696
RF GA +++ + V+E K GSLR L ++ + + + A D+A M ++H +
Sbjct: 761 TRFYGANKQNKKYLFHVSELVKSGSLRDLLLDKE-KPLLYFTQLSIASDIANAMKHLHSI 819
Query: 695 GYIHRDLKSDNLLISADRSIKIADFGVARIEVKTEGMTPETGTYRWMAPEMIQHRPYTQK 516
G IHRDLKS N+LI+ D + K+ DFG +R + MT GT +M+PE+ + Y +
Sbjct: 820 GVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKHMTMNLGTSCYMSPELFKGNGYDET 879
Query: 515 VDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGVRPSIPDDCLPVLRNILTRCWDAD 336
DVY+FGIVLWE++ P++N+ + +V +G RP+IP DC ++ CW
Sbjct: 880 CDVYAFGIVLWEIIARKEPYENINSWSIP-VMVAKGDRPTIPADCPSEYSKLIKACWTDK 938
Query: 335 PEVRPPFTEIVMMLER 288
P+ RP F EI L++
Sbjct: 939 PKKRPSFKEICDTLKK 954
>sp|Q54TA1|DRKC_DICDI Probable serine/threonine-protein kinase drkC
OS=Dictyostelium discoideum GN=drkC PE=3 SV=1
Length = 749
Score = 149 bits (374), Expect = 8e-035
Identities = 86/218 (39%), Positives = 121/218 (55%), Gaps = 10/218 (4%)
Frame = -3
Query: 923 QFQQEVMMLATLKHANIVRFIGACRRSMVWCIVTEYAKGGSLRQFLTKRQNRAVPLKLAV 744
+ QE +++ L+H NI +F+G C IV EY GSL + L + ++
Sbjct: 533 ELAQEATIMSQLRHPNICQFLGTCNNPPEILIVMEYMPLGSLYRIL-HDPSISLDWPRMK 591
Query: 743 KQALDVATGMAYVHGLG--YIHRDLKSDNLLISADRSIKIADFGVA-----RIEVKTEGM 585
ALD+A GM Y+H IHRDLKS NLL+ +KI+DFG++ ++ KT M
Sbjct: 592 SMALDIAKGMNYLHCCDPIVIHRDLKSHNLLVDEHYRVKISDFGLSTRFKKHLDKKT-AM 650
Query: 584 TPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELLTGMVPFQNMTAVQAAFAVVNRGV 405
TP GT W APE++++ PYT+K DV+SF IVLWE++T P+Q M Q +V +
Sbjct: 651 TP-VGTPCWTAPEVLRNDPYTEKADVFSFAIVLWEIVTREDPYQGMPTFQIVISVGQHKL 709
Query: 404 RPSIPDDCLPVLRNILTRCWDADPEVRPPFTEIVMMLE 291
RP +P ++T CW DP+ RP F EIV LE
Sbjct: 710 RPIVPPQVSAPFTRLITECWSEDPQQRPSFQEIVKRLE 747
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,378,909,851
Number of Sequences: 518415
Number of Extensions: 78378909851
Number of Successful Extensions: 523441567
Number of sequences better than 0.0: 0
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