BLASTX 7.6.2
Query= UN19018 /QuerySize=1422
(1421 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q71DJ5|LIP1_ARATH Triacylglycerol lipase 1 OS=Arabidopsis tha... 711 4e-204
sp|Q67ZU1|LIP2_ARATH Triacylglycerol lipase 2 OS=Arabidopsis tha... 278 6e-074
sp|P07098|LIPG_HUMAN Gastric triacylglycerol lipase OS=Homo sapi... 181 1e-044
sp|Q8BM14|LIPK_MOUSE Lipase member K OS=Mus musculus GN=Lipk PE=... 181 2e-044
sp|Q5VXI9|LIPN_HUMAN Lipase member N OS=Homo sapiens GN=LIPN PE=... 176 3e-043
sp|Q5VXJ0|LIPK_HUMAN Lipase member K OS=Homo sapiens GN=LIPK PE=... 174 1e-042
sp|O46108|LIP3_DROME Lipase 3 OS=Drosophila melanogaster GN=Lip3... 173 3e-042
sp|Q5VYY2|LIPM_HUMAN Lipase member M OS=Homo sapiens GN=LIPM PE=... 173 5e-042
sp|Q8K2A6|LIPM_MOUSE Lipase member M OS=Mus musculus GN=Lipm PE=... 169 7e-041
sp|Q4R4S5|LICH_MACFA Lysosomal acid lipase/cholesteryl ester hyd... 133 4e-030
sp|Q9Z0M5|LICH_MOUSE Lysosomal acid lipase/cholesteryl ester hyd... 131 2e-029
sp|P38571|LICH_HUMAN Lysosomal acid lipase/cholesteryl ester hyd... 128 1e-028
sp|Q5W064|LIPJ_HUMAN Lipase member J OS=Homo sapiens GN=LIPJ PE=... 120 4e-026
sp|P04634|LIPG_RAT Gastric triacylglycerol lipase OS=Rattus norv... 119 5e-026
sp|Q3U4B4|LIPN_MOUSE Lipase member N OS=Mus musculus GN=Lipn PE=... 119 6e-026
sp|Q29458|LIPG_BOVIN Gastric triacylglycerol lipase OS=Bos tauru... 118 1e-025
sp|O46107|LIP1_DROME Lipase 1 OS=Drosophila melanogaster GN=Lip1... 117 2e-025
sp|Q64194|LICH_RAT Lysosomal acid lipase/cholesteryl ester hydro... 117 2e-025
sp|P80035|LIPG_CANFA Gastric triacylglycerol lipase OS=Canis fam... 115 9e-025
sp|Q9CPP7|LIPG_MOUSE Gastric triacylglycerol lipase OS=Mus muscu... 114 3e-024
>sp|Q71DJ5|LIP1_ARATH Triacylglycerol lipase 1 OS=Arabidopsis thaliana GN=LIP1
PE=1 SV=1
Length = 393
Score = 711 bits (1834), Expect = 4e-204
Identities = 342/395 (86%), Positives = 368/395 (93%), Gaps = 2/395 (0%)
Frame = +1
Query: 121 MKWLLVAVLTACTISSAVTQSHILRGSPVNSLCADLVHPAGYSCTEHTIQTKDGYILALQ 300
MKWLLVAVLT+ TI SA+TQSH+L GSPVNSLCADL+HPA YSCTEH+IQTKDGYILALQ
Sbjct: 1 MKWLLVAVLTSLTIFSALTQSHLLHGSPVNSLCADLIHPANYSCTEHSIQTKDGYILALQ 60
Query: 301 RVASPAQNLTLQYGPPVLLQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGNVRGTRY 480
RVAS LQ GPPVLLQHGLFMAGDVWFL+S KESLGF+LAD+GFDVW+GNVRGTRY
Sbjct: 61 RVASLGPR--LQSGPPVLLQHGLFMAGDVWFLNSPKESLGFILADHGFDVWVGNVRGTRY 118
Query: 481 SYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQYMYSVANSKIFLVGHSQGTIMSFAALTQ 660
SYGHVTLS+TDKEFWDWSWQDLAMYDLAEM+QY+YS++NSKIFLVGHSQGTIMSFAALTQ
Sbjct: 119 SYGHVTLSDTDKEFWDWSWQDLAMYDLAEMIQYLYSISNSKIFLVGHSQGTIMSFAALTQ 178
Query: 661 PRVAEMVEAAALLCPISYLDHVTAPLVERMVFMHLDQMVVALGLHQINFRSDTLVKLVDS 840
P VAEMVEAAALLCPISYLDHVTAPLVERMVFMHLDQMVVALGLHQINFRSD LVKLVDS
Sbjct: 179 PHVAEMVEAAALLCPISYLDHVTAPLVERMVFMHLDQMVVALGLHQINFRSDMLVKLVDS 238
Query: 841 LCEGHMDCTDFLSSITGKNCCFNASRIEYYLDYEPHPSSVKNLRHLFQMIRKGSFAKFDY 1020
LCEGHMDCTDFL+SITG NCCFNAS+IEYYLDYEPHPSSVKN+RHLFQMIRKG+FA++DY
Sbjct: 239 LCEGHMDCTDFLTSITGTNCCFNASKIEYYLDYEPHPSSVKNIRHLFQMIRKGTFAQYDY 298
Query: 1021 GFLKNILTYGTSKPPEFELGLIPASLPMWMGYGGSDLLADVTDVERTLAELPSRPELLYL 1200
G+ KN+ TYG SKPPEF L IPASLPMWMGYGG+D LADVTDVE TLAELPS PELLYL
Sbjct: 299 GYFKNLRTYGLSKPPEFILSHIPASLPMWMGYGGTDGLADVTDVEHTLAELPSSPELLYL 358
Query: 1201 ENYGHIDFVLSTSAKEDVYMHMIQFFRARKKSSSW 1305
E+YGHIDFVL +SAKEDVY HMIQFFRA+ KSSSW
Sbjct: 359 EDYGHIDFVLGSSAKEDVYKHMIQFFRAKVKSSSW 393
>sp|Q67ZU1|LIP2_ARATH Triacylglycerol lipase 2 OS=Arabidopsis thaliana GN=LIP2
PE=2 SV=1
Length = 418
Score = 278 bits (711), Expect = 6e-074
Identities = 138/365 (37%), Positives = 213/365 (58%), Gaps = 9/365 (2%)
Frame = +1
Query: 214 LCADLVHPAGYSCTEHTIQTKDGYILALQRVASPAQNLTLQYG---PPVLLQHGLFMAGD 384
+CA VH GY C EH + T+DGYIL +QR+ G PVL+QHG+ + G
Sbjct: 51 ICASSVHIFGYKCEEHDVVTQDGYILNMQRIPEGRAGAVAGDGGKRQPVLIQHGILVDGM 110
Query: 385 VWFLDSTKESLGFVLADYGFDVWIGNVRGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLA 564
W L+ ++L +LAD GFDVW+GN RGTR+S H L+ + + FW+W+W +L YDL
Sbjct: 111 SWLLNPADQNLPLILADQGFDVWMGNTRGTRFSRRHKYLNPSQRAFWNWTWDELVSYDLP 170
Query: 565 EMVQYMYSVANSKIFLVGHSQGTIMSFAALTQPRVAEMVEAAALLCPISYLDHVTAPLVE 744
M +++ + KI +GHS GT++ FA+ ++ + + V +AA+L P++YL H+T + +
Sbjct: 171 AMFDHIHGLTGQKIHYLGHSLGTLIGFASFSEKGLVDQVRSAAMLSPVAYLSHMTTVIGD 230
Query: 745 RMVFMHLDQMVVALGLHQINFRSDTLVKLVDSLC-EGHMDCTDFLSSITGKNCCFNASRI 921
L + LG + N +S + + ++C + +DC D +S ITGKNCC NAS I
Sbjct: 231 IAAKTFLAEATSILGWPEFNPKSGLVGDFIKAICLKAGIDCYDLVSVITGKNCCLNASTI 290
Query: 922 EYYLDYEPHPSSVKNLRHLFQMIRKGSFAKFDYGFL-KNILTYGTSKPPEFELGLIPASL 1098
+ +L EP +S KN+ HL Q +R K++YG +NI YG + PP + + IP L
Sbjct: 291 DLFLANEPQSTSTKNMIHLAQTVRDKELRKYNYGSSDRNIKHYGQAIPPAYNISAIPHEL 350
Query: 1099 PMWMGYGGSDLLADVTDVERTLAELP----SRPELLYLENYGHIDFVLSTSAKEDVYMHM 1266
P++ YGG D LADV DVE L + + + ++++Y H DF++ +AK+ VY +
Sbjct: 351 PLFFSYGGLDSLADVKDVEFLLDQFKYHDIDKMNVQFVKDYAHADFIMGVTAKDVVYNQV 410
Query: 1267 IQFFR 1281
FF+
Sbjct: 411 ATFFK 415
>sp|P07098|LIPG_HUMAN Gastric triacylglycerol lipase OS=Homo sapiens GN=LIPF
PE=1 SV=1
Length = 398
Score = 181 bits (458), Expect = 1e-044
Identities = 127/405 (31%), Positives = 204/405 (50%), Gaps = 24/405 (5%)
Frame = +1
Query: 127 WLLVAVLTACTISSAVTQSHIL-----RGSP-VNSLCADLVHPAGYSCTEHTIQTKDGYI 288
WLL LT ++ S + +H L GSP V + ++ GY E+ + T+DGYI
Sbjct: 2 WLL---LTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYI 58
Query: 289 LALQRVASPAQNL-TLQYGPPVLLQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGNV 465
L + R+ +N P V LQHGL + W + SL F+LAD G+DVW+GN
Sbjct: 59 LEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNS 118
Query: 466 RGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQYMYSVANSK-IFLVGHSQGTIMS 642
RG ++ ++ S EFW +S+ ++A YDL + ++ K + VGHSQGT +
Sbjct: 119 RGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIG 178
Query: 643 FAAL-TQPRVAEMVEAAALLCPISYLDHVTAPLVERMVFMHLDQMVVALG---LHQINFR 810
F A T P +A+ ++ L P++ + + T L+ ++ F+ G + NF
Sbjct: 179 FIAFSTNPSLAKRIKTFYALAPVATVKY-TKSLINKLRFVPQSLFKFIFGDKIFYPHNFF 237
Query: 811 SDTLVKLVDSLCEGHMDCTDFLSSITG---KNCCFNASRIEYYLDYEPHPSSVKNLRHLF 981
L V S ++ C++ L I G KN FN SR++ YL + P +SV+N+ H
Sbjct: 238 DQFLATEVCSREMLNLLCSNALFIICGFDSKN--FNTSRLDVYLSHNPAGTSVQNMFHWT 295
Query: 982 QMIRKGSFAKFDYGF-LKNILTYGTSKPPEFELGLIPASLPMWMGYGGSDLLADVTDVER 1158
Q ++ G F +D+G ++N + Y S+PP + + + + +W GG DLLAD DV
Sbjct: 296 QAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVW--NGGKDLLADPQDVGL 353
Query: 1159 TLAELPSRPELLYLENYGHIDFVLSTSAKEDVYMHMIQFFRARKK 1293
L +LP+ + Y H+DF+ + A ++VY ++ KK
Sbjct: 354 LLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK 398
>sp|Q8BM14|LIPK_MOUSE Lipase member K OS=Mus musculus GN=Lipk PE=2 SV=1
Length = 398
Score = 181 bits (457), Expect = 2e-044
Identities = 115/396 (29%), Positives = 196/396 (49%), Gaps = 18/396 (4%)
Frame = +1
Query: 121 MKWLLVAVLTACTISSAVTQSH---ILRGSPVNSLCADLVHPAGYSCTEHTIQTKDGYIL 291
M WLL T C + S + + N ++L+ GY +H + T+DGYIL
Sbjct: 1 MWWLLAT--TCCVLLSGPIDGYKQESITNPEANMNISELISYWGYPYEKHDVITEDGYIL 58
Query: 292 ALQRVASPAQNLTLQYGPP--VLLQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGNV 465
R+ + + + P V LQHGL + + W + SL F+LAD G+DVW+GN
Sbjct: 59 GTYRIPH-GKGCSRKTAPKAVVYLQHGLIASANNWICNLPNNSLAFLLADSGYDVWLGNS 117
Query: 466 RGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQYMYSVANSK-IFLVGHSQGTIMS 642
RG +S H+ LS ++W +SW ++A YDL V + + K +F VGHSQGT ++
Sbjct: 118 RGNTWSRNHLRLSPKSPQYWAFSWDEMAKYDLPATVNLILEKSGQKQLFYVGHSQGTTIA 177
Query: 643 FAAL-TQPRVAEMVEAAALLCPISYLDHVTAPLVERMVFMHLDQMVVALGLHQINFRSDT 819
F A T P +A+ + L P++ + + +P+ +++ + + V G + +
Sbjct: 178 FIAFSTNPELAKKIRLFFALAPVATVKYTRSPM-KKLTTLSRKAVKVLFGDKMFSTHTWF 236
Query: 820 LVKLVDSLCEG---HMDCTDFLSSITGKN-CCFNASRIEYYLDYEPHPSSVKNLRHLFQM 987
+ +C H C++FL S++G + N SR++ YL P +SV+N+ H Q
Sbjct: 237 EQFIATKVCNRKLFHQLCSNFLFSLSGFDPQNLNMSRLDVYLSQSPAGTSVQNMLHWAQA 296
Query: 988 IRKGSFAKFDYGFL-KNILTYGTSKPPEFELGLIPASLPMWMGYGGSDLLADVTDVERTL 1164
+ G FD+G +N++ + PP + + + MW GG D++AD D + L
Sbjct: 297 VNSGQLQAFDWGNPDQNMMHFNQLTPPVYNISKMRVPTAMWS--GGQDVVADAKDTKNLL 354
Query: 1165 AELPSRPELLYLENYGHIDFVLSTSAKEDVYMHMIQ 1272
++ + + +Y H+DF L A ++VY +I+
Sbjct: 355 PKIANLIYYKEIPHYNHMDFYLGQDAPQEVYGDLIR 390
>sp|Q5VXI9|LIPN_HUMAN Lipase member N OS=Homo sapiens GN=LIPN PE=2 SV=2
Length = 398
Score = 176 bits (446), Expect = 3e-043
Identities = 120/402 (29%), Positives = 195/402 (48%), Gaps = 20/402 (4%)
Frame = +1
Query: 121 MKWLLVAVLTACTISSAVTQSHILR-----GSPVNSLCADLVHPAGYSCTEHTIQTKDGY 285
M WLL+ T C I + L V ++++ GY E+ + T+DGY
Sbjct: 1 MMWLLLT--TTCLICGTLNAGGFLDLENEVNPEVWMNTSEIIIYNGYPSEEYEVTTEDGY 58
Query: 286 ILALQRVA-SPAQNLTLQYGPPVLLQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGN 462
IL + R+ + P V +QH LF W + SLGF+LAD G+DVW+GN
Sbjct: 59 ILLVNRIPYGRTHARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWMGN 118
Query: 463 VRGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQYMYS-VANSKIFLVGHSQGTIM 639
RG +S H TLSETD++FW +S+ ++A YDL ++ ++ + K++ +GHS GT +
Sbjct: 119 SRGNTWSRRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLGTTI 178
Query: 640 SFAAL-TQPRVAEMVEAAALLCPISYLDHVTAPLVERMVFMHLDQMVVALGLHQINFRSD 816
F A T P +A+ ++ L P + T + F+ + ++ A+ + F D
Sbjct: 179 GFVAFSTMPELAQRIKMNFALGPTISFKYPTG--IFTRFFLLPNSIIKAVFGTKGFFLED 236
Query: 817 TLVKLVDS-LCEGH---MDCTDFLSSITGKN-CCFNASRIEYYLDYEPHPSSVKNLRHLF 981
K+ + +C + C++F+S G N N SR++ Y+ + P SSV N+ H+
Sbjct: 237 KKTKIASTKICNNKILWLICSEFMSLWAGSNKKNMNQSRMDVYMSHAPTGSSVHNILHIK 296
Query: 982 QMIRKGSFAKFDYG-FLKNILTYGTSKPPEFELGLIPASLPMWMGYGGSDLLADVTDVER 1158
Q+ F +D+G N+ Y S PP ++L + +W GG D+L DV R
Sbjct: 297 QLYHSDEFRAYDWGNDADNMKHYNQSHPPIYDLTAMKVPTAIWA--GGHDVLVTPQDVAR 354
Query: 1159 TLAELPSRPELLYLENYGHIDFVLSTSAKEDVYMHMIQFFRA 1284
L ++ S L ++ H DFV A + +Y +I +A
Sbjct: 355 ILPQIKSLHYFKLLPDWNHFDFVWGLDAPQRMYSEIIALMKA 396
>sp|Q5VXJ0|LIPK_HUMAN Lipase member K OS=Homo sapiens GN=LIPK PE=2 SV=2
Length = 399
Score = 174 bits (441), Expect = 1e-042
Identities = 108/356 (30%), Positives = 180/356 (50%), Gaps = 21/356 (5%)
Frame = +1
Query: 241 GYSCTEHTIQTKDGYILALQRV----ASPAQNLTLQYGPPVLLQHGLFMAGDVWFLDSTK 408
GY E+ + TKDGYIL + R+ P + P V LQHGL + W +
Sbjct: 43 GYPYEEYDVTTKDGYILGIYRIPHGRGCPGRTAP---KPAVYLQHGLIASASNWICNLPN 99
Query: 409 ESLGFVLADYGFDVWIGNVRGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQYMYS 588
SL F+LAD G+DVW+GN RG +S H+ LS E+W +S ++A YDL + ++
Sbjct: 100 NSLAFLLADSGYDVWLGNSRGNTWSRKHLKLSPKSPEYWAFSLDEMAKYDLPATINFIIE 159
Query: 589 VANSK-IFLVGHSQGTIMSFAAL-TQPRVAEMVEAAALLCPISYLDHVTAPLVERMVFMH 762
K ++ VGHSQGT ++F A T P +A+ ++ L P+ + + +P+ +
Sbjct: 160 KTGQKRLYYVGHSQGTTIAFIAFSTNPELAKKIKIFFALAPVVTVKYTQSPMKK---LTT 216
Query: 763 LDQMVVALGLHQINFRSDTLVK--LVDSLCEGHM---DCTDFLSSITGKN-CCFNASRIE 924
L + VV + F TL + +C + C++FL +++G + N SR++
Sbjct: 217 LSRRVVKVLFGDKMFHPHTLFDQFIATKVCNRKLFRRICSNFLFTLSGFDPQNLNMSRLD 276
Query: 925 YYLDYEPHPSSVKNLRHLFQMIRKGSFAKFDYGFL-KNILTYGTSKPPEFELGLIPASLP 1101
YL + P +SV+N+ H Q + G FD+G +N++ + PP + + +
Sbjct: 277 VYLSHNPAGTSVQNMLHWAQAVNSGQLQAFDWGNSDQNMMHFHQLTPPLYNITKMEVPTA 336
Query: 1102 MWMGYGGSDLLADVTDVERTLAELPSRPELLYLENYGHIDFVLSTSAKEDVYMHMI 1269
+W GG D++AD DVE L ++ + + +Y H+DF L A +++Y +I
Sbjct: 337 IW--NGGQDIVADPKDVENLLPQIANLIYYKLIPHYNHVDFYLGEDAPQEIYQDLI 390
>sp|O46108|LIP3_DROME Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1
Length = 394
Score = 173 bits (438), Expect = 3e-042
Identities = 108/377 (28%), Positives = 184/377 (48%), Gaps = 21/377 (5%)
Frame = +1
Query: 187 ILRGSPVNSLCADLVHPAGYSCTEHTIQTKDGYILALQRVASPAQNLTLQYGPPVLLQHG 366
+L GS S C + + GY H + T D YIL + R+ + P L HG
Sbjct: 18 VLAGSRPISDCGERIEDDGYPMERHEVVTSDNYILTMHRIPYSPKTGESSNRPVAFLMHG 77
Query: 367 LFMAGDVWFLDSTKESLGFVLADYGFDVWIGNVRGTRYSYGHVTLSETDKEFWDWSWQDL 546
+ + W L + SL ++LAD G+DVW+GN RG YS H + FW++SW ++
Sbjct: 78 MLSSSSDWVLMGPERSLAYMLADAGYDVWMGNARGNTYSKAHKYWPTYWQIFWNFSWNEI 137
Query: 547 AMYDLAEMVQYMYS-VANSKIFLVGHSQGTIMSFAALTQ-PRVAEMVEAAALLCPISYLD 720
MYD+ M+ Y+ + ++ VGHSQGT + +++ P + +++A LL P +Y+
Sbjct: 138 GMYDVPAMIDYVLAKTGQQQVQYVGHSQGTTVYLVMVSERPEYNDKIKSAHLLGPAAYMG 197
Query: 721 HVTAPLVERM--VFMHLDQMVVALGLHQI----NFRSDTLVKLVDSLCEGHMDCTDFLSS 882
++ +PL + + +V G + F+ D +++ + C + +
Sbjct: 198 NMKSPLTRAFAPILGQPNAIVEVCGSMEFMPSNKFKQDLGIEMCQATSPYADMCANEIFL 257
Query: 883 ITGKNCCFNASRIEYYL-----DYEPHPSSVKNLRHLFQMIRKGSFAKFDYGFLKNILTY 1047
I G ++ +++Y L P +SV H Q G F KFDY L+N Y
Sbjct: 258 IGG----YDTEQLDYELLEHIKATSPAGASVNQNLHFCQEYNSGKFRKFDYTALRNPYEY 313
Query: 1048 GTSKPPEFELGLIPASLPMWMGYGGSDLLADVTDVERTLAELPSR--PELLYLENYGHID 1221
G+ PP+++L A P+ + YG +D + DV+DV + ELP+ L+ E + H+D
Sbjct: 314 GSYFPPDYKLK--NAKAPVLLYYGANDWMCDVSDVRKLRDELPNMALDYLVPFEKWAHLD 371
Query: 1222 FVLSTSAKEDVYMHMIQ 1272
F+ T A++ VY +++
Sbjct: 372 FIWGTEARKYVYDEVLK 388
>sp|Q5VYY2|LIPM_HUMAN Lipase member M OS=Homo sapiens GN=LIPM PE=2 SV=2
Length = 423
Score = 173 bits (436), Expect = 5e-042
Identities = 117/374 (31%), Positives = 190/374 (50%), Gaps = 21/374 (5%)
Frame = +1
Query: 220 ADLVHPAGYSCTEHTIQTKDGYILALQRV-ASPAQNLTLQYGPPVLLQHGLFMAGDVWFL 396
++++ GY C E+ + T+DGYIL++ R+ Q P VLLQHGL W
Sbjct: 50 SEIIQHQGYPCEEYEVATEDGYILSVNRIPRGLVQPKKTGSRPVVLLQHGLVGGASNWIS 109
Query: 397 DSTKESLGFVLADYGFDVWIGNVRGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQ 576
+ SLGF+LAD GFDVW+GN RG +S H TLS EFW +S+ ++A +DL ++
Sbjct: 110 NLPNNSLGFILADAGFDVWMGNSRGNAWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVIN 169
Query: 577 Y-MYSVANSKIFLVGHSQGTIMSFAAL-TQPRVAEMVEAAALLCPISYLDHVTAPLVERM 750
+ + KI+ VG+SQGT M F A T P +A+ ++ L PI+ + H +P +
Sbjct: 170 FILQKTGQEKIYYVGYSQGTTMGFIAFSTMPELAQKIKMYFALAPIATVKHAKSPGTK-- 227
Query: 751 VFMHLDQMVV--ALGLHQINFRSDTLVKLVDSLC-EGHMD--CTDFLSSITGKNC-CFNA 912
F+ L M++ G + +++ L +LV LC + +D C++ + + G N N
Sbjct: 228 -FLLLPDMMIKGLFGKKEFLYQTRFLRQLVIYLCGQVILDQICSNIMLLLGGFNTNNMNM 286
Query: 913 SRIEYYLDYEPHPSSVKNLRHLFQMIRKGSFAKFDYGF-LKNILTYGTSKPPEFELGLIP 1089
SR Y + +SV+N+ H Q + G FD+G KN+ P + + +
Sbjct: 287 SRASVYAAHTLAGTSVQNILHWSQAVNSGELRAFDWGSETKNLEKCNQPTPVRYRVRDMT 346
Query: 1090 ASLPMWMGYGGSDLLADVTDVERTLAELPSRPELLYLEN---YGHIDFVLSTSAKEDVYM 1260
MW GG D L++ DV+ L+E+ + L+Y +N + H+DF+ A +Y
Sbjct: 347 VPTAMWT--GGQDWLSNPEDVKMLLSEVTN---LIYHKNIPEWAHVDFIWGLDAPHRMYN 401
Query: 1261 HMIQFFRARKKSSS 1302
+I + + + S
Sbjct: 402 EIIHLMQQEETNLS 415
>sp|Q8K2A6|LIPM_MOUSE Lipase member M OS=Mus musculus GN=Lipm PE=2 SV=1
Length = 422
Score = 169 bits (426), Expect = 7e-041
Identities = 122/402 (30%), Positives = 199/402 (49%), Gaps = 28/402 (6%)
Frame = +1
Query: 127 WLLVAVLTACTISSAVTQSHI-LRGSPVNSL--CADLVHPAGYSCTEHTIQTKDGYILAL 297
WLL +L A + V H+ + + + ++++ GY E+ + T+DGYIL++
Sbjct: 18 WLL--ILVAYLLQRNVNSGHLPTKAADPEAFMNVSEIIKHKGYPSEEYEVATEDGYILSV 75
Query: 298 QRVASPAQNLTLQYG-PPVLLQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGNVRGT 474
R+ L + P VLLQHGL W + SLGF+LAD GFDVW+GN RG
Sbjct: 76 NRIPRGQTRLKKEGSRPVVLLQHGLLGDASNWISNLPNNSLGFILADAGFDVWMGNSRGN 135
Query: 475 RYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQY-MYSVANSKIFLVGHSQGTIMSFAA 651
+S H TLS EFW +S+ ++A +DL ++ + + K++ VG+SQGT M F A
Sbjct: 136 TWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQKTGQKKVYYVGYSQGTTMGFIA 195
Query: 652 L-TQPRVAEMVEAAALLCPISYLDHVTAPLVERMVFMHLDQMV--VALGLHQINFRSDTL 822
T P +A ++ L PI+ + + +P + F+ L M+ V G + +++
Sbjct: 196 FSTMPELAHKIKMYFALAPIATVKYARSPGTK---FLLLPDMMIKVLFGRQEFLYQTRFF 252
Query: 823 VKLVDSLCEGHM----DCTDFLSSITGKNC-CFNASRIEYYLDYEPHPSSVKNLRHLFQM 987
+L LC G M C++ + + G N N SR Y+ + P +SV+N+ H Q
Sbjct: 253 RQLFIYLC-GQMILDQICSNIILLLGGFNTNNMNMSRANVYVAHTPAGTSVQNILHWSQA 311
Query: 988 IRKGSFAKFDYGF-LKNILTYGTSKPPEFELGLIPASLPMWMGYGGSDLLADVTDVERTL 1164
+ G FD+G KN P +++ + MW GG D L++ DV+ L
Sbjct: 312 VNSGELRAFDWGSETKNQEKCNQPTPIRYKVRDMMVPTAMWT--GGQDWLSNPDDVKTLL 369
Query: 1165 AELPSRPELLYLEN---YGHIDFVLSTSAKEDVYMHMIQFFR 1281
+E+ + L+Y +N + H+DF+ A + VY +I +
Sbjct: 370 SEVTN---LIYHKNIPEWAHVDFIWGLDAPQRVYNEIIHLMK 408
>sp|Q4R4S5|LICH_MACFA Lysosomal acid lipase/cholesteryl ester hydrolase
OS=Macaca fascicularis GN=LIPA PE=2 SV=1
Length = 399
Score = 133 bits (333), Expect = 4e-030
Identities = 74/214 (34%), Positives = 122/214 (57%), Gaps = 5/214 (2%)
Frame = +1
Query: 118 RMKWL-LVAVLTACTISSAVTQSHILRGSP-VNSLCADLVHPAGYSCTEHTIQTKDGYIL 291
+M++L LV L T+ S + + +P N ++++ G+ E+ ++T+DGYIL
Sbjct: 2 KMRFLGLVVCLVLWTLHSEASGGKLTAVNPETNMNVSEIISYWGFPSEEYLVETEDGYIL 61
Query: 292 ALQRVASPAQNLTLQYGPPVL-LQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGNVR 468
L R+ +N + + PV+ LQHGL W + SLGF+LAD GFDVW+GN R
Sbjct: 62 CLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSR 121
Query: 469 GTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQYMYS-VANSKIFLVGHSQGTIMSF 645
G +S H TLS + EFW +S+ ++A YDL + ++ + +++ VGHSQGT + F
Sbjct: 122 GNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGF 181
Query: 646 AALTQ-PRVAEMVEAAALLCPISYLDHVTAPLVE 744
A +Q P +A+ ++ L P+ +D T+P+ +
Sbjct: 182 IAFSQIPELAKRIKMFFALAPVVSVDFCTSPMAK 215
>sp|Q9Z0M5|LICH_MOUSE Lysosomal acid lipase/cholesteryl ester hydrolase OS=Mus
musculus GN=Lipa PE=2 SV=1
Length = 397
Score = 131 bits (327), Expect = 2e-029
Identities = 77/211 (36%), Positives = 115/211 (54%), Gaps = 10/211 (4%)
Frame = +1
Query: 133 LVAVLTACTISSAVTQSHILRGSP-VNSLCADLVHPAGYSCTEHTIQTKDGYILALQRVA 309
LV V T + S V + P VN +++ GY EH++ T DGYIL++ R+
Sbjct: 6 LVFVFTIGILLSRVPTGTVSAVDPEVNMNVTEIIMRWGYPGEEHSVLTGDGYILSIHRIP 65
Query: 310 SPAQNLTLQYG----PPVLLQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGNVRGTR 477
+N +G P V LQHGL W + SLGF+LAD GFDVW+GN RG
Sbjct: 66 RGWKN---HFGKGPRPVVYLQHGLLADSSNWVTNIDNSSLGFLLADRGFDVWMGNSRGNT 122
Query: 478 YSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQYMYS-VANSKIFLVGHSQGTIMSFAAL 654
+S H TLS + EFW +S+ ++A YDL + Y+ + +I+ VGHSQG + F A
Sbjct: 123 WSLKHKTLSVSQDEFWAFSFDEMAKYDLPASINYILNKTGQEQIYYVGHSQGCTIGFIAF 182
Query: 655 TQ-PRVAEMVEAAALLCPISYLDHVTAPLVE 744
+Q P +A+ ++ +L P+ L+ + PL++
Sbjct: 183 SQMPELAKKIKMFLVLAPVLSLNFASGPLLQ 213
>sp|P38571|LICH_HUMAN Lysosomal acid lipase/cholesteryl ester hydrolase OS=Homo
sapiens GN=LIPA PE=1 SV=2
Length = 399
Score = 128 bits (321), Expect = 1e-028
Identities = 73/214 (34%), Positives = 121/214 (56%), Gaps = 5/214 (2%)
Frame = +1
Query: 118 RMKWL-LVAVLTACTISSAVTQSHILRGSP-VNSLCADLVHPAGYSCTEHTIQTKDGYIL 291
+M++L LV L T+ S + + P N ++++ G+ E+ ++T+DGYIL
Sbjct: 2 KMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYIL 61
Query: 292 ALQRVASPAQNLTLQYGPPVL-LQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGNVR 468
L R+ +N + + PV+ LQHGL W + SLGF+LAD GFDVW+GN R
Sbjct: 62 CLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSR 121
Query: 469 GTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQYMYS-VANSKIFLVGHSQGTIMSF 645
G +S H TLS + EFW +S+ ++A YDL + ++ + +++ VGHSQGT + F
Sbjct: 122 GNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGF 181
Query: 646 AALTQ-PRVAEMVEAAALLCPISYLDHVTAPLVE 744
A +Q P +A+ ++ L P++ + T+P+ +
Sbjct: 182 IAFSQIPELAKRIKMFFALGPVASVAFCTSPMAK 215
>sp|Q5W064|LIPJ_HUMAN Lipase member J OS=Homo sapiens GN=LIPJ PE=2 SV=2
Length = 366
Score = 120 bits (299), Expect = 4e-026
Identities = 67/176 (38%), Positives = 97/176 (55%), Gaps = 5/176 (2%)
Frame = +1
Query: 241 GYSCTEHTIQTKDGYILALQRVA--SPAQNLTLQYGPPVLLQHGLFMAGDVWFLDSTKES 414
GY E+ I T+DGYIL L R+ N L V LQHGL + W + S
Sbjct: 11 GYPDEEYDIVTEDGYILGLYRIPYWRTDNNKNLAQRVVVYLQHGLLTSASSWISNLPNNS 70
Query: 415 LGFVLADYGFDVWIGNVRGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQY-MYSV 591
LGF+LAD G+DVW+GN RG +S H+ L + KEFW +S+ ++A YDL + + +
Sbjct: 71 LGFILADAGYDVWMGNSRGNTWSRKHLYLETSSKEFWAFSFDEMAKYDLPASIDFTVKQT 130
Query: 592 ANSKIFLVGHSQGTIMSFAAL-TQPRVAEMVEAAALLCPISYLDHVTAPLVERMVF 756
+IF VGHSQGT + F T ++AE ++ L P+ ++ +PL+ RM +
Sbjct: 131 RQEEIFYVGHSQGTTIGFITFSTISKIAERIKIFFALAPVFSTKYLKSPLI-RMTY 185
>sp|P04634|LIPG_RAT Gastric triacylglycerol lipase OS=Rattus norvegicus GN=Lipf
PE=2 SV=1
Length = 395
Score = 119 bits (298), Expect = 5e-026
Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 13/213 (6%)
Frame = +1
Query: 127 WLLVAVLTACTISSAVTQSHILRGS------PVNSLCADLVHPAGYSCTEHTIQTKDGYI 288
WLL+ T A H L G N + ++ GY C E+ + T+DGYI
Sbjct: 2 WLLLITSVISTFGGA----HGLFGKLGPGNPEANMNISQMITYWGYPCQEYEVVTEDGYI 57
Query: 289 LALQRVASPAQNL-TLQYGPPVLLQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGNV 465
L + R+ N + P V LQHGL + W + SL F+LAD G+DVW+GN
Sbjct: 58 LGVYRIPHGKNNSENIGKRPVVYLQHGLIASATNWIANLPNNSLAFMLADAGYDVWLGNS 117
Query: 466 RGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQY-MYSVANSKIFLVGHSQGTIMS 642
RG +S +V S EFW +S+ ++A YDL + + + KI VGHSQGT +
Sbjct: 118 RGNTWSRKNVYYSPDSVEFWAFSFDEMAKYDLPATINFIVQKTGQEKIHYVGHSQGTTIG 177
Query: 643 FAAL-TQPRVAEMVEAAALLCPISYLDHVTAPL 738
F A T P +A+ ++ L P++ + + +PL
Sbjct: 178 FIAFSTNPTLAKKIKTFYALAPVATVKYTQSPL 210
>sp|Q3U4B4|LIPN_MOUSE Lipase member N OS=Mus musculus GN=Lipn PE=2 SV=1
Length = 400
Score = 119 bits (297), Expect = 6e-026
Identities = 70/212 (33%), Positives = 110/212 (51%), Gaps = 10/212 (4%)
Frame = +1
Query: 121 MKWLLVAVLTACTISSAVTQSHILR-----GSPVNSLCADLVHPAGYSCTEHTIQTKDGY 285
M WL + TAC I ++ L V ++++ GY E+ + T DGY
Sbjct: 3 MMWLFLT--TACLIPGTLSAGGFLDFENKVNPEVWMNASEIIMYNGYPSEEYDVTTADGY 60
Query: 286 ILALQRVA-SPAQNLTLQYGPPVLLQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGN 462
ILA+ R+ AQ P V +QH LF W + SLGF+LAD G+DVW+GN
Sbjct: 61 ILAINRIPHGRAQTGQTGPRPVVYMQHALFADNAYWLENFANGSLGFILADAGYDVWMGN 120
Query: 463 VRGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQYMYS-VANSKIFLVGHSQGTIM 639
RG +S H TLS +++FW +S+ ++A YDL ++ ++ + K++ +GHS GT +
Sbjct: 121 SRGNTWSRRHKTLSANEEKFWAFSFNEMAKYDLPGIIDFIVNKTGQEKLYFIGHSLGTTI 180
Query: 640 SFAAL-TQPRVAEMVEAAALLCPISYLDHVTA 732
F A T P +A+ ++ L P+ + T+
Sbjct: 181 GFVAFSTMPELAQRIKMNFALGPVISFKYPTS 212
>sp|Q29458|LIPG_BOVIN Gastric triacylglycerol lipase OS=Bos taurus GN=LIPF PE=1
SV=1
Length = 397
Score = 118 bits (295), Expect = 1e-025
Identities = 71/201 (35%), Positives = 103/201 (51%), Gaps = 4/201 (1%)
Frame = +1
Query: 121 MKWLLVAVLTACTISSAVTQSHILRGSPVNSL-CADLVHPAGYSCTEHTIQTKDGYILAL 297
M WLLV V +A + +P S+ + ++ GY H + T DGYIL +
Sbjct: 1 MWWLLVTVCFIHMSGNAFCFLGKIAKNPEASMNVSQMISYWGYPSEMHKVITADGYILQV 60
Query: 298 QRVASPAQNLT-LQYGPPVLLQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGNVRGT 474
R+ N L P V LQHGL + W + K SLGF+LAD G+DVW+GN RG
Sbjct: 61 YRIPHGKNNANHLGQRPVVFLQHGLLGSATNWISNLPKNSLGFLLADAGYDVWLGNSRGN 120
Query: 475 RYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQY-MYSVANSKIFLVGHSQGTIMSFAA 651
++ H+ S EFW +S+ ++A YDL + + + K+ VGHSQGT + F A
Sbjct: 121 TWAQEHLYYSPDSPEFWAFSFDEMAEYDLPSTIDFILRRTGQKKLHYVGHSQGTTIGFIA 180
Query: 652 L-TQPRVAEMVEAAALLCPIS 711
T P +AE ++ L P++
Sbjct: 181 FSTSPTLAEKIKVFYALAPVA 201
>sp|O46107|LIP1_DROME Lipase 1 OS=Drosophila melanogaster GN=Lip1 PE=2 SV=2
Length = 439
Score = 117 bits (293), Expect = 2e-025
Identities = 63/186 (33%), Positives = 94/186 (50%), Gaps = 9/186 (4%)
Frame = +1
Query: 226 LVHPAGYSCTEHTIQTKDGYILALQRVASPAQNLTLQYGPPVLLQHGLFMAGDVWFLDST 405
L+ GY H + T+DGYIL + R+ Q PP LLQHGL + + +
Sbjct: 71 LIAKYGYESEVHHVTTEDGYILTMHRIRK-------QGAPPFLLQHGLVDSSAGFVVMGP 123
Query: 406 KESLGFVLADYGFDVWIGNVRGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQYMY 585
SL ++LAD+ +DVW+GN RG RYS H TL + +FWD+SW ++ MYDL M+ ++
Sbjct: 124 NVSLAYLLADHNYDVWLGNARGNRYSRNHTTLDPDESKFWDFSWHEIGMYDLPAMIDHVL 183
Query: 586 SVAN-SKIFLVGHSQGTIMSFAALT-QPRVAEMVEAAALLCPISYLDHVTAPLVERMVFM 759
V K+ GHSQG F + +P + V + L P Y R + +
Sbjct: 184 KVTGFPKLHYAGHSQGCTSFFVMCSMRPAYNDKVVSMQALAPAVYAKETEDHPYIRAISL 243
Query: 760 HLDQMV 777
+ + +V
Sbjct: 244 YFNSLV 249
>sp|Q64194|LICH_RAT Lysosomal acid lipase/cholesteryl ester hydrolase OS=Rattus
norvegicus GN=Lipa PE=2 SV=1
Length = 397
Score = 117 bits (292), Expect = 2e-025
Identities = 62/168 (36%), Positives = 96/168 (57%), Gaps = 5/168 (2%)
Frame = +1
Query: 256 EHTIQTKDGYILALQRVASPAQNLTLQYGPPVLL---QHGLFMAGDVWFLDSTKESLGFV 426
EH++QT DGYIL + R+ +N + PV+ +HG W + SLGF+
Sbjct: 46 EHSVQTGDGYILGVHRIPHGRKNQFDKGPKPVVYLQWRHGFLADSSNWVTNIDNNSLGFI 105
Query: 427 LADYGFDVWIGNVRGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQYMYS-VANSK 603
LAD GFDVW+GN RG +S H TLS + E+W +S+ ++A YDL + Y+ + +
Sbjct: 106 LADAGFDVWMGNSRGNTWSRKHKTLSVSQDEYWAFSFDEMAKYDLPASINYILNKTGQEQ 165
Query: 604 IFLVGHSQGTIMSFAALTQ-PRVAEMVEAAALLCPISYLDHVTAPLVE 744
++ VGHSQG + F A +Q P +A+ V+ L P+ L+ + P+V+
Sbjct: 166 LYNVGHSQGCTIGFIAFSQMPELAKKVKMFFALAPVLSLNFASGPMVK 213
>sp|P80035|LIPG_CANFA Gastric triacylglycerol lipase OS=Canis familiaris GN=LIPF
PE=1 SV=2
Length = 398
Score = 115 bits (287), Expect = 9e-025
Identities = 69/218 (31%), Positives = 112/218 (51%), Gaps = 12/218 (5%)
Frame = +1
Query: 127 WLLVAVLTACTISSAVTQSHILRGS------PVNSLCADLVHPAGYSCTEHTIQTKDGYI 288
WLL LTA ++ S + +H L G V + ++ GY E+ + T+DGYI
Sbjct: 2 WLL---LTAASVISTLGTTHGLFGKLHPTNPEVTMNISQMITYWGYPAEEYEVVTEDGYI 58
Query: 289 LALQRVASPAQNL-TLQYGPPVLLQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGNV 465
L + R+ +N + P LQHGL + W + SL F+LAD G+DVW+GN
Sbjct: 59 LGIDRIPYGRKNSENIGRRPVAFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNS 118
Query: 466 RGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQY-MYSVANSKIFLVGHSQGTIMS 642
RG ++ ++ S EFW +S+ ++A YDL + + + K+ VGHSQGT +
Sbjct: 119 RGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFILKKTGQDKLHYVGHSQGTTIG 178
Query: 643 FAAL-TQPRVAEMVEAAALLCPISYLDHVTAPLVERMV 753
F A T P++A+ ++ L P++ + + L + M+
Sbjct: 179 FIAFSTNPKLAKRIKTFYALAPVATVKYTETLLNKLML 216
>sp|Q9CPP7|LIPG_MOUSE Gastric triacylglycerol lipase OS=Mus musculus GN=Lipf
PE=2 SV=1
Length = 395
Score = 114 bits (283), Expect = 3e-024
Identities = 69/212 (32%), Positives = 107/212 (50%), Gaps = 13/212 (6%)
Frame = +1
Query: 127 WLLVAVLTACTISSAVTQSHILRGS------PVNSLCADLVHPAGYSCTEHTIQTKDGYI 288
WLL+ ++ SA +H L G N + ++ GY E+ + T+DGYI
Sbjct: 2 WLLLVT----SVLSAFGGAHGLFGKLGPKNPEANMNVSQMITYWGYPSEEYEVVTEDGYI 57
Query: 289 LALQRVASPAQNL-TLQYGPPVLLQHGLFMAGDVWFLDSTKESLGFVLADYGFDVWIGNV 465
L + R+ +N + P LQHGL + W + SL F+LAD G+DVW+GN
Sbjct: 58 LGVYRIPYGKKNSENIGKRPVAYLQHGLIASATNWITNLPNNSLAFILADAGYDVWLGNS 117
Query: 466 RGTRYSYGHVTLSETDKEFWDWSWQDLAMYDLAEMVQY-MYSVANSKIFLVGHSQGTIMS 642
RG +S +V S EFW +S+ ++A YDL + + + KI VGHSQGT +
Sbjct: 118 RGNTWSRKNVYYSPDSVEFWAFSFDEMAKYDLPATIDFIVQKTGQEKIHYVGHSQGTTIG 177
Query: 643 FAAL-TQPRVAEMVEAAALLCPISYLDHVTAP 735
F A T P +A+ ++ L P++ + + +P
Sbjct: 178 FIAFSTNPALAKKIKRFYALAPVATVKYTESP 209
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,378,909,851
Number of Sequences: 518415
Number of Extensions: 78378909851
Number of Successful Extensions: 523441567
Number of sequences better than 0.0: 0
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