BLASTX 7.6.2
Query= UN19105 /QuerySize=802
(801 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O80585|MTHR2_ARATH Methylenetetrahydrofolate reductase 2 OS=A... 457 4e-128
sp|Q9SE60|MTHR1_ARATH Methylenetetrahydrofolate reductase 1 OS=A... 439 2e-122
sp|Q9SE94|MTHR1_MAIZE Methylenetetrahydrofolate reductase 1 OS=Z... 414 5e-115
sp|Q75HE6|MTHR_ORYSJ Probable methylenetetrahydrofolate reductas... 403 1e-111
sp|P53128|MTHR2_YEAST Methylenetetrahydrofolate reductase 2 OS=S... 232 3e-060
sp|P46151|MTHR1_YEAST Methylenetetrahydrofolate reductase 1 OS=S... 183 1e-045
sp|O74927|MTHR2_SCHPO Methylenetetrahydrofolate reductase 2 OS=S... 176 2e-043
sp|Q10258|MTHR1_SCHPO Methylenetetrahydrofolate reductase 1 OS=S... 151 5e-036
sp|O67422|METF_AQUAE 5,10-methylenetetrahydrofolate reductase OS... 121 6e-027
sp|Q17693|MTHR_CAEEL Probable methylenetetrahydrofolate reductas... 79 2e-014
sp|Q5I598|MTHR_BOVIN Methylenetetrahydrofolate reductase OS=Bos ... 79 4e-014
sp|P42898|MTHR_HUMAN Methylenetetrahydrofolate reductase OS=Homo... 79 4e-014
sp|Q60HE5|MTHR_MACFA Methylenetetrahydrofolate reductase OS=Maca... 79 4e-014
sp|Q9WU20|MTHR_MOUSE Methylenetetrahydrofolate reductase OS=Mus ... 79 4e-014
sp|P0AEZ1|METF_ECOLI 5,10-methylenetetrahydrofolate reductase OS... 77 2e-013
sp|P0AEZ2|METF_SHIFL 5,10-methylenetetrahydrofolate reductase OS... 77 2e-013
sp|P71319|METF_PECCC 5,10-methylenetetrahydrofolate reductase OS... 76 2e-013
sp|P11003|METF_SALTY 5,10-methylenetetrahydrofolate reductase OS... 75 4e-013
sp|P45208|METF_HAEIN 5,10-methylenetetrahydrofolate reductase OS... 68 7e-011
>sp|O80585|MTHR2_ARATH Methylenetetrahydrofolate reductase 2 OS=Arabidopsis
thaliana GN=MTHFR2 PE=1 SV=2
Length = 594
Score = 457 bits (1175), Expect = 4e-128
Identities = 214/240 (89%), Positives = 228/240 (95%)
Frame = +2
Query: 41 MKVVDKIKSWTDEGKTTFSFEFFPPRTEDGVDNLFERMDRLVAYGPAFCDITWGAGGTTA 220
MKV+DKI+S DEGKT FSFEFFPP+TEDGVDNLFERMDR+VAYGP FCDITWGAGG+TA
Sbjct: 1 MKVIDKIQSLADEGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGSTA 60
Query: 221 DLTLDIVSRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGENK 400
DLTLDI SRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHG++K
Sbjct: 61 DLTLDIASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDK 120
Query: 401 FVQVEGGFGCALDLVNHIRSKYGDYFGVAVAGYPEAHPDVIGENGLASKEAYESDLEYLK 580
FVQVEGGF CALDLVNHIRSKYGDYFG+ VAGYPEAHPDVIGENGLAS EAY+SDLEYLK
Sbjct: 121 FVQVEGGFDCALDLVNHIRSKYGDYFGITVAGYPEAHPDVIGENGLASNEAYQSDLEYLK 180
Query: 581 KKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKCPIVPGIMPINNYKGFLRMIGFCRPR 760
KK+DAGADLIVTQLF+DTDI LKFVNDCRQIGI CPIVPGIMPINNY+GFLRM GFC+ +
Sbjct: 181 KKIDAGADLIVTQLFYDTDIFLKFVNDCRQIGISCPIVPGIMPINNYRGFLRMTGFCKTK 240
>sp|Q9SE60|MTHR1_ARATH Methylenetetrahydrofolate reductase 1 OS=Arabidopsis
thaliana GN=MTHFR1 PE=1 SV=1
Length = 592
Score = 439 bits (1127), Expect = 2e-122
Identities = 204/240 (85%), Positives = 226/240 (94%)
Frame = +2
Query: 41 MKVVDKIKSWTDEGKTTFSFEFFPPRTEDGVDNLFERMDRLVAYGPAFCDITWGAGGTTA 220
MKVVDKIKS T++G+T FSFEFFPP+TEDGV+NLFERMDRLV+YGP FCDITWGAGG+TA
Sbjct: 1 MKVVDKIKSVTEQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGGSTA 60
Query: 221 DLTLDIVSRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGENK 400
DLTL+I SRMQNV+CVE+MMHLTCTNMP+EKIDHALETIRSNGIQNVLALRGDPPHG++K
Sbjct: 61 DLTLEIASRMQNVICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQDK 120
Query: 401 FVQVEGGFGCALDLVNHIRSKYGDYFGVAVAGYPEAHPDVIGENGLASKEAYESDLEYLK 580
FVQVEGGF CALDLVNHIRSKYGDYFG+ VAGYPEAHPDVI +GLA+ E+Y+SDL YLK
Sbjct: 121 FVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAYLK 180
Query: 581 KKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKCPIVPGIMPINNYKGFLRMIGFCRPR 760
KKVDAGADLIVTQLF+DTDI LKFVNDCRQIGI CPIVPGIMPI+NYKGFLRM GFC+ +
Sbjct: 181 KKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTK 240
>sp|Q9SE94|MTHR1_MAIZE Methylenetetrahydrofolate reductase 1 OS=Zea mays PE=2
SV=1
Length = 593
Score = 414 bits (1062), Expect = 5e-115
Identities = 191/240 (79%), Positives = 218/240 (90%)
Frame = +2
Query: 41 MKVVDKIKSWTDEGKTTFSFEFFPPRTEDGVDNLFERMDRLVAYGPAFCDITWGAGGTTA 220
MKV++KI +G+T FSFE+FPP+TE+GV+NLFERMDR+VA+GP+FCDITWGAGG+TA
Sbjct: 1 MKVIEKILEAAGDGRTAFSFEYFPPKTEEGVENLFERMDRMVAHGPSFCDITWGAGGSTA 60
Query: 221 DLTLDIVSRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGENK 400
DLTL+I +RMQN+VCVE+MMHLTCTNMPVEKIDHALETI+SNGIQNVLALRGDPPHG++K
Sbjct: 61 DLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQDK 120
Query: 401 FVQVEGGFGCALDLVNHIRSKYGDYFGVAVAGYPEAHPDVIGENGLASKEAYESDLEYLK 580
FVQVEGGF CALDLV HIR+KYGDYFG+ VAGYPEAHPD I G A+ EAY +DL YLK
Sbjct: 121 FVQVEGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQGEGGATLEAYSNDLAYLK 180
Query: 581 KKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKCPIVPGIMPINNYKGFLRMIGFCRPR 760
+KVDAGADLIVTQLF+DTDI LKFVNDCRQIGI CPIVPGIMPINNYKGFLRM GFC+ +
Sbjct: 181 RKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCKTK 240
>sp|Q75HE6|MTHR_ORYSJ Probable methylenetetrahydrofolate reductase OS=Oryza
sativa subsp. japonica GN=Os03g0815200 PE=2 SV=1
Length = 594
Score = 403 bits (1034), Expect = 1e-111
Identities = 186/240 (77%), Positives = 214/240 (89%)
Frame = +2
Query: 41 MKVVDKIKSWTDEGKTTFSFEFFPPRTEDGVDNLFERMDRLVAYGPAFCDITWGAGGTTA 220
MKV++KI+ +G+T FSFE+FPP+TE+G+DNLFERMDR+VA+GP FCDITWGAGG+TA
Sbjct: 1 MKVIEKIQEAAADGRTVFSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGGSTA 60
Query: 221 DLTLDIVSRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGENK 400
DLTL+I +RMQN+VCVE+MMHLTCTNMPVEKID AL TI+SNGIQNVLALRGDPPHG++K
Sbjct: 61 DLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDDALTTIKSNGIQNVLALRGDPPHGQDK 120
Query: 401 FVQVEGGFGCALDLVNHIRSKYGDYFGVAVAGYPEAHPDVIGENGLASKEAYESDLEYLK 580
FVQV GGF CALDLV HIR+KYGDYFG+ VAGYPEAHPD I A+ EAY +DL YLK
Sbjct: 121 FVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQSTEGATPEAYSNDLAYLK 180
Query: 581 KKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKCPIVPGIMPINNYKGFLRMIGFCRPR 760
+KVDAGADLI+TQLF+DTDI LKFVNDCRQIGI CPIVPGIMPINNYKGFLRM GFC+ +
Sbjct: 181 QKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCKTK 240
>sp|P53128|MTHR2_YEAST Methylenetetrahydrofolate reductase 2 OS=Saccharomyces
cerevisiae GN=MET13 PE=1 SV=2
Length = 600
Score = 232 bits (590), Expect = 3e-060
Identities = 117/235 (49%), Positives = 158/235 (67%), Gaps = 10/235 (4%)
Frame = +2
Query: 41 MKVVDKIKSWTD-EGKTTFSFEFFPPRTEDGVDNLFERMDRLV-AYGPAFCDITWGA-GG 211
MK+ +K++ GK T+SFE+F P+T GV NL++RMDR+ A P F DITW A GG
Sbjct: 1 MKITEKLEQHRQTSGKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGGG 60
Query: 212 TTADLTLDIVSRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHG 391
+ L+ D+V+ Q+V+ +E+ MHLTCTNMP+ ID ALE +G QN+LALRGDPP
Sbjct: 61 RLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPRD 120
Query: 392 ENKFVQVEGGFGCALDLVNHIRSKYGDYFGVAVAGYPEAHPDVIGENGLASKEAYESDLE 571
+ VEGGF A DL+ +I+SKYGD+F + VAGYPE HP+ L +K+ + DLE
Sbjct: 121 AENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPE------LPNKDV-KLDLE 173
Query: 572 YLKKKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKCPIVPGIMPINNYKGFLR 736
YLK+K+DAG D I+TQ+F+D D + + + R G+ PI+PGIMPI Y FLR
Sbjct: 174 YLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLR 228
>sp|P46151|MTHR1_YEAST Methylenetetrahydrofolate reductase 1 OS=Saccharomyces
cerevisiae GN=MET12 PE=1 SV=2
Length = 657
Score = 183 bits (464), Expect = 1e-045
Identities = 104/217 (47%), Positives = 132/217 (60%), Gaps = 6/217 (2%)
Frame = +2
Query: 95 SFEFFPPRTEDGVDNLFERMDRLVAYGPAFCDITWGAGGTTADLTLDIVSRMQNVVCVES 274
S EFFPP+TE G NL ERM R+ A P F +TWGAGGTTA+ TL + S Q + +
Sbjct: 16 SLEFFPPKTELGTRNLMERMHRMTALDPLFITVTWGAGGTTAEKTLTLASLAQQTLNIPV 75
Query: 275 MMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGEN--KFVQVEGGFGCALDLVN 448
MHLTCTN ID AL+ + GI+N+LALRGDPP GE+ E F A+DLV
Sbjct: 76 CMHLTCTNTEKAIIDDALDRCYNAGIRNILALRGDPPIGEDWLDSQSNESPFKYAVDLVR 135
Query: 449 HIRSKYGDYFGVAVAGYPEAHPDVIGENGLASKEAYESDLEYLKKKVDAGADLIVTQLFF 628
+I+ YGD F V VA YPE H + E ++ DL YLK+KV+AGAD ++TQLF+
Sbjct: 136 YIKQSYGDKFCVGVAAYPEGHCEGEAE---GHEQDPLKDLVYLKEKVEAGADFVITQLFY 192
Query: 629 DTDILLKFVNDCRQ-IGIKCPIVPGIMPINNYKGFLR 736
D + L F R+ I P+ PG+MPIN+Y F R
Sbjct: 193 DVEKFLTFEMLFRERISQDLPLFPGLMPINSYLLFHR 229
>sp|O74927|MTHR2_SCHPO Methylenetetrahydrofolate reductase 2
OS=Schizosaccharomyces pombe GN=met11 PE=2 SV=2
Length = 641
Score = 176 bits (445), Expect = 2e-043
Identities = 97/242 (40%), Positives = 139/242 (57%), Gaps = 9/242 (3%)
Frame = +2
Query: 41 MKVVDKIKSWTDEGKTTFSFEFFPPRTEDGVDNLFERMDRLVA-YGPAFCDITWGAGGTT 217
MK+VD I G +SFE+FPP+T G++NL R+ R+ P F +TWG G+T
Sbjct: 1 MKIVDLIDK-IPNGNAFYSFEYFPPKTTVGLENLSSRITRMSRNMMPLFSSVTWGTAGST 59
Query: 218 ADLTLDIVSRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGEN 397
A++++ + ++ + + +HLTCTN+ ID ALET + GI+N+LALRGDPP +
Sbjct: 60 AEVSIYLAKMLEQHHKIPACLHLTCTNVDKAIIDKALETAKEYGIRNILALRGDPPLNSD 119
Query: 398 KFVQVEGGFGCALDLVNHIRSKYGDYFGVAVAGYPEAHPDVIGENGLASKEAYESDLEYL 577
+ F A+DLV +IR KYGDYF + VA YPE H D N + D+ +L
Sbjct: 120 HWEGKVSEFEHAVDLVRYIREKYGDYFCIGVAAYPEGHVD---SNVPELSKDPLRDIPFL 176
Query: 578 KKKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKC----PIVPGIMPINNYKGFLRMIG 745
+KV+AGAD I+TQ+F++ + +KF N R PI+P IMPI +Y RM
Sbjct: 177 IEKVEAGADFIITQIFYEPEAFIKFENFVRNHSSNALRNIPIIPAIMPIQSYGSLKRMTR 236
Query: 746 FC 751
C
Sbjct: 237 LC 238
>sp|Q10258|MTHR1_SCHPO Methylenetetrahydrofolate reductase 1
OS=Schizosaccharomyces pombe GN=met9 PE=1 SV=1
Length = 603
Score = 151 bits (381), Expect = 5e-036
Identities = 79/161 (49%), Positives = 107/161 (66%), Gaps = 3/161 (1%)
Frame = +2
Query: 41 MKVVDKIKSWTDEGKTTFSFEFFPPRTEDGVDNLFERMDRLVAYG-PAFCDITWGAGGTT 217
MK+ DK+ + K T+S+EFFPP+T GV NL+ R+DR+ +G P F D+TWGAGGT+
Sbjct: 1 MKISDKLLHPDWKEKVTYSYEFFPPKTSTGVQNLYNRIDRMKTWGRPMFVDVTWGAGGTS 60
Query: 218 ADLTLDIVSRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGEN 397
++LT IV+ +Q V++ MHLTCTNM E ID AL+ G +N+LALRGDP +
Sbjct: 61 SELTPGIVNVIQTDFEVDTCMHLTCTNMSTEMIDAALKRAHETGCRNILALRGDPVK-DT 119
Query: 398 KFVQVEGGFGCALDLVNHIRSKYGDYFGVAVAGYPEAH-PD 517
+ + E GF A DLV +IR+ Y D F + VAGYPE + PD
Sbjct: 120 DWTEGESGFRYASDLVRYIRTHYNDEFCIGVAGYPEGYSPD 160
>sp|O67422|METF_AQUAE 5,10-methylenetetrahydrofolate reductase OS=Aquifex
aeolicus GN=metF PE=3 SV=1
Length = 296
Score = 121 bits (303), Expect = 6e-027
Identities = 62/154 (40%), Positives = 91/154 (59%)
Frame = +2
Query: 56 KIKSWTDEGKTTFSFEFFPPRTEDGVDNLFERMDRLVAYGPAFCDITWGAGGTTADLTLD 235
KI +G + SFEFFPP+TE+G LFE + +L P F +T+GAGG+T D T +
Sbjct: 2 KIGDILRKGVFSISFEFFPPKTEEGERQLFETIRKLEKLNPTFVSVTYGAGGSTRDRTRN 61
Query: 236 IVSRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGENKFVQVE 415
IV ++ + M HLTC E++ L+ ++ GI+N+LALRGD P + + +
Sbjct: 62 IVQKIHEETNLTVMAHLTCIAHTREELIDILQDYKNIGIENILALRGDVPRDKPDWRPPK 121
Query: 416 GGFGCALDLVNHIRSKYGDYFGVAVAGYPEAHPD 517
G A +LV IR ++GD+F + VA YPE HP+
Sbjct: 122 GACKYAKELVELIRKEFGDWFSIGVASYPEGHPE 155
Score = 67 bits (161), Expect = 2e-010
Identities = 29/65 (44%), Positives = 41/65 (63%)
Frame = +2
Query: 557 ESDLEYLKKKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKCPIVPGIMPINNYKGFLR 736
E +++Y K+KV+AGAD +TQ+FF D +FV C+ GI I+PGIMPI N+K +
Sbjct: 160 EWEVKYFKEKVEAGADFSITQMFFVNDYYYRFVEMCKNAGIDISIIPGIMPITNFKQIRK 219
Query: 737 MIGFC 751
C
Sbjct: 220 FASLC 224
>sp|Q17693|MTHR_CAEEL Probable methylenetetrahydrofolate reductase
OS=Caenorhabditis elegans GN=C06A8.1 PE=1 SV=2
Length = 663
Score = 79 bits (194), Expect = 2e-014
Identities = 35/63 (55%), Positives = 47/63 (74%)
Frame = +2
Query: 551 AYESDLEYLKKKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKCPIVPGIMPINNYKGF 730
+Y++DL YLK K DAGA+ ++TQLFF+ + KFV DCR+IGI PI+PGIMPI Y+
Sbjct: 219 SYKADLMYLKAKCDAGANFVITQLFFEAETFEKFVRDCREIGITQPIIPGIMPIMGYESI 278
Query: 731 LRM 739
R+
Sbjct: 279 KRI 281
>sp|Q5I598|MTHR_BOVIN Methylenetetrahydrofolate reductase OS=Bos taurus GN=MTHFR
PE=2 SV=1
Length = 655
Score = 79 bits (192), Expect = 4e-014
Identities = 32/65 (49%), Positives = 48/65 (73%)
Frame = +2
Query: 548 EAYESDLEYLKKKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKCPIVPGIMPINNYKG 727
E++E+DL++LK+KV AGAD I+TQLFF+ + +FV C +IGI CP++PGI PI Y
Sbjct: 204 ESFEADLKHLKEKVAAGADFIITQLFFEAETFFRFVKACSEIGITCPVLPGIFPIQGYHS 263
Query: 728 FLRMI 742
+++
Sbjct: 264 LRQLV 268
>sp|P42898|MTHR_HUMAN Methylenetetrahydrofolate reductase OS=Homo sapiens
GN=MTHFR PE=1 SV=3
Length = 656
Score = 79 bits (192), Expect = 4e-014
Identities = 33/64 (51%), Positives = 46/64 (71%)
Frame = +2
Query: 551 AYESDLEYLKKKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKCPIVPGIMPINNYKGF 730
++E+DL++LK+KV AGAD I+TQLFF+ D +FV C +GI CPIVPGI PI Y
Sbjct: 206 SFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSL 265
Query: 731 LRMI 742
+++
Sbjct: 266 RQLV 269
>sp|Q60HE5|MTHR_MACFA Methylenetetrahydrofolate reductase OS=Macaca fascicularis
GN=MTHFR PE=2 SV=1
Length = 656
Score = 79 bits (192), Expect = 4e-014
Identities = 33/64 (51%), Positives = 46/64 (71%)
Frame = +2
Query: 551 AYESDLEYLKKKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKCPIVPGIMPINNYKGF 730
++E+DL++LK+KV AGAD I+TQLFF+ D +FV C +GI CPIVPGI PI Y
Sbjct: 206 SFEADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSL 265
Query: 731 LRMI 742
+++
Sbjct: 266 RQLV 269
>sp|Q9WU20|MTHR_MOUSE Methylenetetrahydrofolate reductase OS=Mus musculus
GN=Mthfr PE=2 SV=1
Length = 654
Score = 79 bits (192), Expect = 4e-014
Identities = 34/70 (48%), Positives = 46/70 (65%)
Frame = +2
Query: 533 GLASKEAYESDLEYLKKKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKCPIVPGIMPI 712
G E++E DL++LK+KV AGAD I+TQLFF+ FV C +IGI CPI+PGI PI
Sbjct: 199 GHPDAESFEDDLKHLKEKVSAGADFIITQLFFEASTFFSFVKACTEIGISCPILPGIFPI 258
Query: 713 NNYKGFLRMI 742
Y +++
Sbjct: 259 QGYTSLRQLV 268
>sp|P0AEZ1|METF_ECOLI 5,10-methylenetetrahydrofolate reductase OS=Escherichia
coli (strain K12) GN=metF PE=1 SV=1
Length = 296
Score = 77 bits (187), Expect = 2e-013
Identities = 38/108 (35%), Positives = 61/108 (56%)
Frame = +2
Query: 77 EGKTTFSFEFFPPRTEDGVDNLFERMDRLVAYGPAFCDITWGAGGTTADLTLDIVSRMQN 256
+G+ SFEFFPPRT + L+ +DRL + P F +T+GA D T I+ +++
Sbjct: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79
Query: 257 VVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGENK 400
+E+ HLTC + +++ +NGI++++ALRGD P G K
Sbjct: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127
>sp|P0AEZ2|METF_SHIFL 5,10-methylenetetrahydrofolate reductase OS=Shigella
flexneri GN=metF PE=3 SV=1
Length = 296
Score = 77 bits (187), Expect = 2e-013
Identities = 38/108 (35%), Positives = 61/108 (56%)
Frame = +2
Query: 77 EGKTTFSFEFFPPRTEDGVDNLFERMDRLVAYGPAFCDITWGAGGTTADLTLDIVSRMQN 256
+G+ SFEFFPPRT + L+ +DRL + P F +T+GA D T I+ +++
Sbjct: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKGIKD 79
Query: 257 VVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGENK 400
+E+ HLTC + +++ +NGI++++ALRGD P G K
Sbjct: 80 RTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127
>sp|P71319|METF_PECCC 5,10-methylenetetrahydrofolate reductase OS=Pectobacterium
carotovorum subsp. carotovorum GN=metF PE=3 SV=1
Length = 298
Score = 76 bits (186), Expect = 2e-013
Identities = 38/108 (35%), Positives = 60/108 (55%)
Frame = +2
Query: 77 EGKTTFSFEFFPPRTEDGVDNLFERMDRLVAYGPAFCDITWGAGGTTADLTLDIVSRMQN 256
+G+ SFEFFPPRT D + L+ +DRL + P F +T+GA D T I+ ++
Sbjct: 20 QGRINVSFEFFPPRTSDMEETLWSSIDRLSSLKPKFVSVTYGANSGERDRTHSIIKTIKE 79
Query: 257 VVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGENK 400
+E+ HLTC + E++ + +GI++++ALRGD P K
Sbjct: 80 RTGLEAAPHLTCIDASREQLREIAQDYWESGIRHIVALRGDLPQEGGK 127
>sp|P11003|METF_SALTY 5,10-methylenetetrahydrofolate reductase OS=Salmonella
typhimurium GN=metF PE=3 SV=2
Length = 296
Score = 75 bits (184), Expect = 4e-013
Identities = 37/108 (34%), Positives = 60/108 (55%)
Frame = +2
Query: 77 EGKTTFSFEFFPPRTEDGVDNLFERMDRLVAYGPAFCDITWGAGGTTADLTLDIVSRMQN 256
+G+ SFEFFPPRT + L+ +DRL + P F +T+GA D T ++ ++
Sbjct: 20 QGQINVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGERDRTHSVIKGIKE 79
Query: 257 VVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGENK 400
+E+ HLTC + +++ +NGI++++ALRGD P G K
Sbjct: 80 RTGLEAAPHLTCIDATRDELRTIARDYWNNGIRHIVALRGDLPPGSGK 127
>sp|P45208|METF_HAEIN 5,10-methylenetetrahydrofolate reductase OS=Haemophilus
influenzae GN=metF PE=3 SV=1
Length = 292
Score = 68 bits (164), Expect = 7e-011
Identities = 34/81 (41%), Positives = 52/81 (64%), Gaps = 5/81 (6%)
Frame = +2
Query: 506 AHPDVIGENGLASKEAYESDLEYLKKKVDAGADLIVTQLFFDTDILLKFVNDCRQIGIKC 685
A+P+V E ++ ++DL LK+K+DAGA+ ++TQ FFD + L+F + C IGI
Sbjct: 149 AYPEVHPE-----AKSAQADLINLKRKIDAGANHVITQFFFDIENYLRFRDRCASIGIDT 203
Query: 686 PIVPGIMPINNYKGFLRMIGF 748
IVPGI+P+ N+K +M F
Sbjct: 204 EIVPGILPVTNFKQLQKMASF 224
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,378,909,851
Number of Sequences: 518415
Number of Extensions: 78378909851
Number of Successful Extensions: 523441567
Number of sequences better than 0.0: 0
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