BLASTX 7.6.2
Query= UN19476 /QuerySize=1451
(1450 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9M2P4|SINA2_ARATH E3 ubiquitin-protein ligase SINAT2 OS=Arab... 634 8e-181
sp|P93748|SINA1_ARATH Putative E3 ubiquitin-protein ligase SINAT... 597 8e-170
sp|Q84JL3|SINA3_ARATH E3 ubiquitin-protein ligase SINAT3 OS=Arab... 472 4e-132
sp|Q8S3N1|SINA5_ARATH E3 ubiquitin-protein ligase SINAT5 OS=Arab... 454 8e-127
sp|Q9STN8|SINA4_ARATH E3 ubiquitin-protein ligase SINAT4 OS=Arab... 452 4e-126
sp|P61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A OS=Mus ... 163 5e-039
sp|Q920M9|SIAH1_RAT E3 ubiquitin-protein ligase SIAH1 OS=Rattus ... 163 5e-039
sp|Q8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 OS=Homo ... 162 9e-039
sp|Q06985|SIA1B_MOUSE E3 ubiquitin-protein ligase SIAH1B OS=Mus ... 161 1e-038
sp|Q7ZVG6|SIAH1_DANRE E3 ubiquitin-protein ligase Siah1 OS=Danio... 160 3e-038
sp|Q86MW9|SINA_SCHMA E3 ubiquitin-protein ligase sina OS=Schisto... 160 3e-038
sp|P61093|SINA_DROER E3 ubiquitin-protein ligase sina OS=Drosoph... 156 4e-037
sp|P21461|SINA_DROME E3 ubiquitin-protein ligase sina OS=Drosoph... 156 4e-037
sp|Q8I147|SINA_DROWI E3 ubiquitin-protein ligase sina OS=Drosoph... 156 4e-037
sp|Q8T3Y0|SINAL_DROME Probable E3 ubiquitin-protein ligase sinah... 154 2e-036
sp|P29304|SINA_DROVI E3 ubiquitin-protein ligase sina OS=Drosoph... 152 7e-036
sp|A8X679|SIAH1_CAEBR E3 ubiquitin-protein ligase siah-1 OS=Caen... 143 5e-033
sp|Q965X6|SIAH1_CAEEL E3 ubiquitin-protein ligase siah-1 OS=Caen... 139 5e-032
sp|Q7SYL3|SIAH2_DANRE E3 ubiquitin-protein ligase Siah2 OS=Danio... 139 6e-032
sp|O43255|SIAH2_HUMAN E3 ubiquitin-protein ligase SIAH2 OS=Homo ... 136 4e-031
>sp|Q9M2P4|SINA2_ARATH E3 ubiquitin-protein ligase SINAT2 OS=Arabidopsis
thaliana GN=SINAT2 PE=2 SV=1
Length = 308
Score = 634 bits (1633), Expect = 8e-181
Identities = 297/311 (95%), Positives = 301/311 (96%), Gaps = 3/311 (0%)
Frame = -3
Query: 1262 MAPGGSALKEVLESTSTGMDYEVKMAKAEVNNNTNNKPTKSGSAGVGKYGMHSNNGVYEL 1083
MAPGGSALKEV+ES STGMDYEVK AK EVN NNKPTK GSAG+GKYG+HSNNGVYEL
Sbjct: 1 MAPGGSALKEVMESNSTGMDYEVKTAKVEVN---NNKPTKPGSAGIGKYGIHSNNGVYEL 57
Query: 1082 LECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEKVAESLEVP 903
LECPVCTNLMYPPIHQCPNGHTLCSN K RVQNTCPTCRYELGNIRCLALEKVAESLEVP
Sbjct: 58 LECPVCTNLMYPPIHQCPNGHTLCSNCKLRVQNTCPTCRYELGNIRCLALEKVAESLEVP 117
Query: 902 CRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLKDDHKVDMH 723
CRYQ+LGCHDIFPYYSKLKHEQHCRFRPY CPYAGSECSVTGDIPTLVVHLKDDHKVDMH
Sbjct: 118 CRYQNLGCHDIFPYYSKLKHEQHCRFRPYTCPYAGSECSVTGDIPTLVVHLKDDHKVDMH 177
Query: 722 DGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDEN 543
DGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDEN
Sbjct: 178 DGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDEN 237
Query: 542 EAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDRQELK 363
EAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDRQELK
Sbjct: 238 EAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDRQELK 297
Query: 362 LRVTGRIWKEE 330
LRVTGRIWKEE
Sbjct: 298 LRVTGRIWKEE 308
>sp|P93748|SINA1_ARATH Putative E3 ubiquitin-protein ligase SINAT1
OS=Arabidopsis thaliana GN=SINAT1 PE=2 SV=1
Length = 305
Score = 597 bits (1538), Expect = 8e-170
Identities = 282/311 (90%), Positives = 292/311 (93%), Gaps = 6/311 (1%)
Frame = -3
Query: 1262 MAPGGSALKEVLESTSTGMDYEVKMAKAEVNNNTNNKPTKSGSAGVGKYGMHSNNGVYEL 1083
MAPGGSALKE LES STG+DYEVKMAK E N+KPTKSGS +GK+ HS+NGVYEL
Sbjct: 1 MAPGGSALKEALESNSTGVDYEVKMAKVE----ANSKPTKSGSGSIGKF--HSSNGVYEL 54
Query: 1082 LECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEKVAESLEVP 903
LECPVCTNLMYPPIHQCPNGHTLCS+ K RVQNTCPTCRYELGNIRCLALEKVAESLEVP
Sbjct: 55 LECPVCTNLMYPPIHQCPNGHTLCSSCKLRVQNTCPTCRYELGNIRCLALEKVAESLEVP 114
Query: 902 CRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLKDDHKVDMH 723
CRYQ+LGC DIFPYYSKLKHEQHCRFR Y+CPYAGSECSVTGDIPTLV HLKDDHKVDMH
Sbjct: 115 CRYQNLGCQDIFPYYSKLKHEQHCRFRSYSCPYAGSECSVTGDIPTLVDHLKDDHKVDMH 174
Query: 722 DGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDEN 543
DGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDEN
Sbjct: 175 DGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDEN 234
Query: 542 EAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDRQELK 363
EAKKFSYSLEVGAH RKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSG D++ELK
Sbjct: 235 EAKKFSYSLEVGAHSRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGSDKEELK 294
Query: 362 LRVTGRIWKEE 330
LRVTGRIWKEE
Sbjct: 295 LRVTGRIWKEE 305
>sp|Q84JL3|SINA3_ARATH E3 ubiquitin-protein ligase SINAT3 OS=Arabidopsis
thaliana GN=SINAT3 PE=2 SV=1
Length = 326
Score = 472 bits (1213), Expect = 4e-132
Identities = 218/286 (76%), Positives = 244/286 (85%), Gaps = 2/286 (0%)
Frame = -3
Query: 1187 AKAEVNNNTNNKPTKSGSAGVGKYGMHSNNGVYELLECPVCTNLMYPPIHQCPNGHTLCS 1008
A +++TNN T +A G + + V+ELLECPVCTN MYPPIHQC NGHTLCS
Sbjct: 28 ASVSKHHHTNNNTTNVNAAASGL--LPTTTSVHELLECPVCTNSMYPPIHQCHNGHTLCS 85
Query: 1007 NRKARVQNTCPTCRYELGNIRCLALEKVAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCR 828
KARV N CPTCR ELG+IRCLALEKVAESLE+PC++ SLGC +IFPYYSKLKHE C
Sbjct: 86 TCKARVHNRCPTCRQELGDIRCLALEKVAESLELPCKHMSLGCPEIFPYYSKLKHETVCN 145
Query: 827 FRPYACPYAGSECSVTGDIPTLVVHLKDDHKVDMHDGCTFNHRYVKSNPHEVENATWMLT 648
FRPY+CPYAGSECSVTGDIP LV HL+DDHKVDMH GCTFNHRYVKSNP EVENATWMLT
Sbjct: 146 FRPYSCPYAGSECSVTGDIPFLVAHLRDDHKVDMHSGCTFNHRYVKSNPREVENATWMLT 205
Query: 647 VFNCFGRQFCLHFEAFQLGMAPVYMAFLRFMGDENEAKKFSYSLEVGAHGRKLTWQGIPR 468
VF+CFG+ FCLHFEAFQLGMAPVYMAFLRFMGDE EA+ ++YSLEVG +GRKL W+G PR
Sbjct: 206 VFHCFGQYFCLHFEAFQLGMAPVYMAFLRFMGDETEARNYNYSLEVGGYGRKLIWEGTPR 265
Query: 467 SIRDSHRKVRDSQDGLIIPRNLALYFSGGDRQELKLRVTGRIWKEE 330
S+RDSHRKVRDS DGLII RN+AL+FSGGDR+ELKLRVTGRIWKE+
Sbjct: 266 SVRDSHRKVRDSHDGLIIQRNMALFFSGGDRKELKLRVTGRIWKEQ 311
>sp|Q8S3N1|SINA5_ARATH E3 ubiquitin-protein ligase SINAT5 OS=Arabidopsis
thaliana GN=SINAT5 PE=1 SV=2
Length = 309
Score = 454 bits (1167), Expect = 8e-127
Identities = 205/255 (80%), Positives = 226/255 (88%)
Frame = -3
Query: 1094 VYELLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEKVAES 915
VYELLECPVCTN MYPPIHQC NGHTLCS K+RV N CPTCR ELG+IRCLALEKVAES
Sbjct: 40 VYELLECPVCTNSMYPPIHQCHNGHTLCSTCKSRVHNRCPTCRQELGDIRCLALEKVAES 99
Query: 914 LEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLKDDHK 735
LE+PC+Y +LGC IFPYYSKLKHE C FRPY+CPYAGSEC+ GDI LV HL+DDHK
Sbjct: 100 LELPCKYYNLGCLGIFPYYSKLKHESQCNFRPYSCPYAGSECAAVGDITFLVAHLRDDHK 159
Query: 734 VDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFM 555
VDMH GCTFNHRYVKSNP EVENATWMLTVF CFG+ FCLHFEAFQLGMAPVYMAFLRFM
Sbjct: 160 VDMHTGCTFNHRYVKSNPREVENATWMLTVFQCFGQYFCLHFEAFQLGMAPVYMAFLRFM 219
Query: 554 GDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDR 375
GDE++A+ ++YSLEVG GRK TW+G PRS+RDSHRKVRDS DGLII RN+AL+FSGGD+
Sbjct: 220 GDEDDARNYTYSLEVGGSGRKQTWEGTPRSVRDSHRKVRDSHDGLIIQRNMALFFSGGDK 279
Query: 374 QELKLRVTGRIWKEE 330
+ELKLRVTGRIWKE+
Sbjct: 280 KELKLRVTGRIWKEQ 294
>sp|Q9STN8|SINA4_ARATH E3 ubiquitin-protein ligase SINAT4 OS=Arabidopsis
thaliana GN=SINAT4 PE=2 SV=1
Length = 327
Score = 452 bits (1161), Expect = 4e-126
Identities = 207/266 (77%), Positives = 227/266 (85%)
Frame = -3
Query: 1127 VGKYGMHSNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNI 948
VG VYELLECPVCT MYPPIHQC NGHTLCS K RV N CPTCR ELG+I
Sbjct: 47 VGPTATAPATSVYELLECPVCTYSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDI 106
Query: 947 RCLALEKVAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIP 768
RCLALEKVAESLE+PC++ +LGC +IFPYYSKLKHE C FRPY+CPYAGSEC + GDIP
Sbjct: 107 RCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYSCPYAGSECGIVGDIP 166
Query: 767 TLVVHLKDDHKVDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGM 588
LV HL+DDHKVDMH G TFNHRYVKSNP EVENATWMLTVF+CFG+ FCLHFEAFQLGM
Sbjct: 167 FLVAHLRDDHKVDMHAGSTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGM 226
Query: 587 APVYMAFLRFMGDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPR 408
PVYMAFLRFMGDE +A+ +SYSLEVG GRKLTW+G PRSIRDSHRKVRDS DGLII R
Sbjct: 227 GPVYMAFLRFMGDEEDARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQR 286
Query: 407 NLALYFSGGDRQELKLRVTGRIWKEE 330
N+AL+FSGGDR+ELKLRVTG+IWKE+
Sbjct: 287 NMALFFSGGDRKELKLRVTGKIWKEQ 312
>sp|P61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus
GN=Siah1a PE=1 SV=1
Length = 282
Score = 163 bits (410), Expect = 5e-039
Identities = 90/243 (37%), Positives = 133/243 (54%), Gaps = 8/243 (3%)
Frame = -3
Query: 1106 SNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEK 927
SNN + L ECPVC + + PPI QC +GH +CSN + ++ CPTCR LG+IR LA+EK
Sbjct: 31 SNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRNLAMEK 89
Query: 926 VAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLK 747
VA S+ PC+Y S GC P+ K +HE+ C FRPY+CP G+ C G + ++ HL
Sbjct: 90 VANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLM 149
Query: 746 DDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVY 576
HK + G N P V+ W++ + +CFG F L E + +
Sbjct: 150 HQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQEKYDGHQQF 205
Query: 575 MAFLRFMGDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLAL 396
A ++ +G +A+ F+Y LE+ H R+LTW+ PRSI + + D L+ ++A
Sbjct: 206 FAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQ 265
Query: 395 YFS 387
F+
Sbjct: 266 LFA 268
>sp|Q920M9|SIAH1_RAT E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus
GN=Siah1 PE=1 SV=2
Length = 282
Score = 163 bits (410), Expect = 5e-039
Identities = 90/243 (37%), Positives = 133/243 (54%), Gaps = 8/243 (3%)
Frame = -3
Query: 1106 SNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEK 927
SNN + L ECPVC + + PPI QC +GH +CSN + ++ CPTCR LG+IR LA+EK
Sbjct: 31 SNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRNLAMEK 89
Query: 926 VAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLK 747
VA S+ PC+Y S GC P+ K +HE+ C FRPY+CP G+ C G + ++ HL
Sbjct: 90 VANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLM 149
Query: 746 DDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVY 576
HK + G N P V+ W++ + +CFG F L E + +
Sbjct: 150 HQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQEKYDGHQQF 205
Query: 575 MAFLRFMGDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLAL 396
A ++ +G +A+ F+Y LE+ H R+LTW+ PRSI + + D L+ ++A
Sbjct: 206 FAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQ 265
Query: 395 YFS 387
F+
Sbjct: 266 LFA 268
>sp|Q8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 OS=Homo sapiens
GN=SIAH1 PE=1 SV=2
Length = 282
Score = 162 bits (408), Expect = 9e-039
Identities = 90/243 (37%), Positives = 132/243 (54%), Gaps = 8/243 (3%)
Frame = -3
Query: 1106 SNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEK 927
SNN + L ECPVC + + PPI QC +GH +CSN + ++ CPTCR LG+IR LA+EK
Sbjct: 31 SNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRNLAMEK 89
Query: 926 VAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLK 747
VA S+ PC+Y S GC P+ K HE+ C FRPY+CP G+ C G + ++ HL
Sbjct: 90 VANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLM 149
Query: 746 DDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVY 576
HK + G N P V+ W++ + +CFG F L E + +
Sbjct: 150 HQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQEKYDGHQQF 205
Query: 575 MAFLRFMGDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLAL 396
A ++ +G +A+ F+Y LE+ H R+LTW+ PRSI + + D L+ ++A
Sbjct: 206 FAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQ 265
Query: 395 YFS 387
F+
Sbjct: 266 LFA 268
>sp|Q06985|SIA1B_MOUSE E3 ubiquitin-protein ligase SIAH1B OS=Mus musculus
GN=Siah1b PE=2 SV=2
Length = 282
Score = 161 bits (407), Expect = 1e-038
Identities = 89/243 (36%), Positives = 133/243 (54%), Gaps = 8/243 (3%)
Frame = -3
Query: 1106 SNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEK 927
SNN + L ECPVC + + PPI QC +GH +CSN + ++ CPTCR LG+IR LA+EK
Sbjct: 31 SNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRNLAVEK 89
Query: 926 VAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLK 747
VA S+ PC+Y + GC P+ K +HE+ C FRPY+CP G+ C G + ++ HL
Sbjct: 90 VANSVLFPCKYSASGCEITLPHTKKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLM 149
Query: 746 DDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVY 576
HK + G N P V+ W++ + +CFG F L E + +
Sbjct: 150 HQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQEKYDGHQQF 205
Query: 575 MAFLRFMGDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLAL 396
A ++ +G +A+ F+Y LE+ H R+LTW+ PRSI + + D L+ ++A
Sbjct: 206 FAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQ 265
Query: 395 YFS 387
F+
Sbjct: 266 LFA 268
>sp|Q7ZVG6|SIAH1_DANRE E3 ubiquitin-protein ligase Siah1 OS=Danio rerio GN=siah1
PE=2 SV=2
Length = 282
Score = 160 bits (404), Expect = 3e-038
Identities = 89/243 (36%), Positives = 133/243 (54%), Gaps = 8/243 (3%)
Frame = -3
Query: 1106 SNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEK 927
SN+ + L ECPVC + + PPI QC +GH +CSN + ++ CPTCR LG+IR LA+EK
Sbjct: 31 SNSDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRNLAMEK 89
Query: 926 VAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLK 747
VA S+ PC+Y S GC P+ K +HE+ C FRPY+CP G+ C G + ++ HL
Sbjct: 90 VANSVLFPCKYASSGCEVTLPHTDKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLL 149
Query: 746 DDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVY 576
HK + G N P V+ W++ + +CFG F L E + +
Sbjct: 150 HQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQEKYDGHQQF 205
Query: 575 MAFLRFMGDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLAL 396
A ++ +G +A+ F+Y LE+ H R+LTW+ PRSI + + D L+ ++A
Sbjct: 206 FAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQ 265
Query: 395 YFS 387
F+
Sbjct: 266 LFA 268
>sp|Q86MW9|SINA_SCHMA E3 ubiquitin-protein ligase sina OS=Schistosoma mansoni
GN=SINA PE=1 SV=1
Length = 371
Score = 160 bits (404), Expect = 3e-038
Identities = 86/236 (36%), Positives = 131/236 (55%), Gaps = 9/236 (3%)
Frame = -3
Query: 1085 LLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEKVAESLEV 906
L ECPVC + PPI QC +GH +C++ ++++ ++CPTCR L NIR LA+EK+A S+
Sbjct: 123 LFECPVCMDYALPPIMQCQSGHIVCASCRSKL-SSCPTCRGNLDNIRNLAMEKLASSVLF 181
Query: 905 PCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLKDDHK--- 735
PC+Y + GC + F Y SK +HE C +RPY CP G+ C G++ ++ HL HK
Sbjct: 182 PCKYSTSGCPETFHYTSKSEHEAACEYRPYDCPCPGASCKWLGELEQVMPHLVHHHKSIT 241
Query: 734 VDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFM 555
+ F + S P V+ W++ + +CFG F L E + ++ A ++ +
Sbjct: 242 TLQGEDIVFLATDI-SLPGAVD---WVM-MQSCFGHSFMLVLEKQERVPDQIFFALVQLI 296
Query: 554 GDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFS 387
G +A +F Y LE+ H R+LTW+ PRSI D + D L+ N A F+
Sbjct: 297 GTRKQADQFVYRLELNGHRRRLTWEACPRSIHDGVQSAIAVSDCLVFDSNTAHSFA 352
>sp|P61093|SINA_DROER E3 ubiquitin-protein ligase sina OS=Drosophila erecta
GN=sina PE=3 SV=1
Length = 314
Score = 156 bits (394), Expect = 4e-037
Identities = 100/308 (32%), Positives = 156/308 (50%), Gaps = 13/308 (4%)
Frame = -3
Query: 1265 TMAPGGSALKEVLESTSTGMDYEVKMAKAEVNNNTNNKPTKSGSAGVGKYGMHSNNGVYE 1086
T A G+ V +TST + N ++++ + S SAG G GM ++ +
Sbjct: 13 TAAAAGAGATGVATNTSTSTGSSSAGNTSSANTSSSSSSSLS-SAGGGDAGMSAD--LTS 69
Query: 1085 LLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEKVAESLEV 906
L ECPVC + + PPI QC +GH +C + ++++ CPTCR L NIR LA+EKVA +++
Sbjct: 70 LFECPVCFDYVLPPILQCSSGHLVCVSCRSKL-TCCPTCRGPLANIRNLAMEKVASNVKF 128
Query: 905 PCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLKDDHK-VD 729
PC++ GC Y K +HE+ C RPY CP G+ C G + ++ HL HK +
Sbjct: 129 PCKHSGYGCTASLVYTEKTEHEETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSIT 188
Query: 728 MHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVYMAFLRFM 555
G N P V+ W++ + +CFG F L E + + A ++ +
Sbjct: 189 TLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLI 244
Query: 554 GDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDR 375
G EA+ F Y LE+ + R+LTW+ +PRSI + + D L+ ++A F+ D
Sbjct: 245 GSRKEAENFVYRLELNGNRRRLTWEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFA--DN 302
Query: 374 QELKLRVT 351
L + VT
Sbjct: 303 GNLGINVT 310
>sp|P21461|SINA_DROME E3 ubiquitin-protein ligase sina OS=Drosophila
melanogaster GN=sina PE=1 SV=2
Length = 314
Score = 156 bits (394), Expect = 4e-037
Identities = 100/308 (32%), Positives = 156/308 (50%), Gaps = 13/308 (4%)
Frame = -3
Query: 1265 TMAPGGSALKEVLESTSTGMDYEVKMAKAEVNNNTNNKPTKSGSAGVGKYGMHSNNGVYE 1086
T A G+ V +TST + N ++++ + S SAG G GM ++ +
Sbjct: 13 TAAAAGAGATGVATNTSTSTGSSSAGNTSSANTSSSSSSSLS-SAGGGDAGMSAD--LTS 69
Query: 1085 LLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEKVAESLEV 906
L ECPVC + + PPI QC +GH +C + ++++ CPTCR L NIR LA+EKVA +++
Sbjct: 70 LFECPVCFDYVLPPILQCSSGHLVCVSCRSKL-TCCPTCRGPLANIRNLAMEKVASNVKF 128
Query: 905 PCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLKDDHK-VD 729
PC++ GC Y K +HE+ C RPY CP G+ C G + ++ HL HK +
Sbjct: 129 PCKHSGYGCTASLVYTEKTEHEETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSIT 188
Query: 728 MHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVYMAFLRFM 555
G N P V+ W++ + +CFG F L E + + A ++ +
Sbjct: 189 TLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLI 244
Query: 554 GDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDR 375
G EA+ F Y LE+ + R+LTW+ +PRSI + + D L+ ++A F+ D
Sbjct: 245 GSRKEAENFVYRLELNGNRRRLTWEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFA--DN 302
Query: 374 QELKLRVT 351
L + VT
Sbjct: 303 GNLGINVT 310
>sp|Q8I147|SINA_DROWI E3 ubiquitin-protein ligase sina OS=Drosophila willistoni
GN=sina PE=3 SV=1
Length = 331
Score = 156 bits (394), Expect = 4e-037
Identities = 105/335 (31%), Positives = 163/335 (48%), Gaps = 15/335 (4%)
Frame = -3
Query: 1337 NNKINPKRANHLTTS*IQRHLI*LTMAPGGSALKEVLESTSTGMDYEVKMAKAEVNNNTN 1158
+NKINPKR + GG++ + +TG + A ++ N
Sbjct: 2 SNKINPKRREPTAAAAAAVAAGVGGGVGGGASGVATANTNTTGSSSTGGSSSAGTTSSAN 61
Query: 1157 NKPTKS---GSAGVGKYGMHSNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQ 987
+ S SAG G GM ++ + L ECPVC + + PPI QC +GH +C + ++++
Sbjct: 62 TSSSSSSSLSSAGGGDAGMSAD--LTSLFECPVCFDYVLPPILQCSSGHLVCVSCRSKL- 118
Query: 986 NTCPTCRYELGNIRCLALEKVAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACP 807
CPTCR L NIR LA+EKVA +++ PC++ GC Y K +HE+ C RPY CP
Sbjct: 119 TCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEHEETCECRPYLCP 178
Query: 806 YAGSECSVTGDIPTLVVHLKDDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCF 633
G+ C G + ++ HL HK + G N P V+ W++ + +CF
Sbjct: 179 CPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCF 234
Query: 632 GRQFCLHFEAFQ-LGMAPVYMAFLRFMGDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRD 456
G F L E + + A ++ +G EA+ F Y LE+ + R+LTW+ +PRSI +
Sbjct: 235 GHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWEAMPRSIHE 294
Query: 455 SHRKVRDSQDGLIIPRNLALYFSGGDRQELKLRVT 351
+ D L+ ++A F+ D L + VT
Sbjct: 295 GVASAIHNSDCLVFDTSIAQLFA--DNGNLGINVT 327
>sp|Q8T3Y0|SINAL_DROME Probable E3 ubiquitin-protein ligase sinah OS=Drosophila
melanogaster GN=sinah PE=1 SV=2
Length = 351
Score = 154 bits (388), Expect = 2e-036
Identities = 87/235 (37%), Positives = 121/235 (51%), Gaps = 7/235 (2%)
Frame = -3
Query: 1085 LLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEKVAESLEV 906
LLECPVC + PPI QCP GH +CS ++++ CP CR + NIR LA+EKVA L
Sbjct: 103 LLECPVCFGYIMPPIMQCPRGHLICSTCRSKL-TICPVCRVFMTNIRSLAMEKVASKLIF 161
Query: 905 PCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLKDDHK-VD 729
PC++ GC Y K KHE+ C RPY CPY +CS G + + HL H+ V
Sbjct: 162 PCKHSHFGCRARLSYAEKTKHEEDCECRPYFCPYPDDKCSWQGPLRDVYQHLMSSHENVI 221
Query: 728 MHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGM-APVYMAFLRFMG 552
+G N + +E A V +C GR F L E LG Y R +G
Sbjct: 222 TMEG---NDIIFLATNVNLEGALDWTMVQSCHGRHFLLSLEKINLGEDCQQYFTACRMIG 278
Query: 551 DENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFS 387
+A +F Y++ + A+ R L WQ PRSIR++ ++ D L++ ++ FS
Sbjct: 279 SMKDAAEFVYNISLEAYNRTLRWQSKPRSIRENFSSFTNA-DFLVLNKHTVELFS 332
>sp|P29304|SINA_DROVI E3 ubiquitin-protein ligase sina OS=Drosophila virilis
GN=sina PE=3 SV=1
Length = 314
Score = 152 bits (383), Expect = 7e-036
Identities = 97/308 (31%), Positives = 155/308 (50%), Gaps = 13/308 (4%)
Frame = -3
Query: 1265 TMAPGGSALKEVLESTSTGMDYEVKMAKAEVNNNTNNKPTKSGSAGVGKYGMHSNNGVYE 1086
T+A +A V+ +T+T N +++ + SAG G GM ++ +
Sbjct: 13 TVAAAVAAATAVV-ATNTSSSTGSSAGNTSSANTSSSSSSSLSSAGGGDAGMSAD--LTS 69
Query: 1085 LLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEKVAESLEV 906
L ECPVC + + PPI QC +GH +C + ++++ CPTCR L NIR LA+E+VA +++
Sbjct: 70 LFECPVCFDYVLPPILQCSSGHLVCVSCRSKL-TCCPTCRGPLANIRNLAMEEVASNVKF 128
Query: 905 PCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLKDDHK-VD 729
PC++ GC Y K +HE+ C RPY CP G+ C G + ++ HL HK +
Sbjct: 129 PCKHSGYGCTASLVYTEKTEHEETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSIT 188
Query: 728 MHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ-LGMAPVYMAFLRFM 555
G N P V+ W++ + +CFG F L E + + A ++ +
Sbjct: 189 TLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLI 244
Query: 554 GDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDR 375
G EA+ F Y LE+ + R+LTW+ +PRSI + + D L+ ++A F+ D
Sbjct: 245 GSRKEAENFVYRLELNGNRRRLTWEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFA--DN 302
Query: 374 QELKLRVT 351
L + VT
Sbjct: 303 GNLGINVT 310
>sp|A8X679|SIAH1_CAEBR E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis
briggsae GN=siah-1 PE=3 SV=2
Length = 434
Score = 143 bits (358), Expect = 5e-033
Identities = 86/276 (31%), Positives = 138/276 (50%), Gaps = 19/276 (6%)
Frame = -3
Query: 1172 NNNTNNKPTKSGSAG--------VGKYGMHSNNGVYELLECPVCTNLMYPPIHQCPNGHT 1017
+N T++ PT + + VG S+ + + ECPVC M PP QCP+GH
Sbjct: 131 SNTTHSTPTVAQAMQSVAPHIPIVGAGADDSSAEILSVFECPVCLEYMLPPYMQCPSGHL 190
Query: 1016 LCSNRKARVQNTCPTCRYELGNIRCLALEKVAESLEVPCRYQSLGCHDIFPYYSKLKHEQ 837
+CSN + ++Q CPTCR ++R L LEK+A ++ PC++ + GC F + K+ HE+
Sbjct: 191 VCSNCRPKLQ-CCPTCRGPTPSVRNLGLEKIANTVRFPCKFSNSGCPLNFHHIDKMDHEE 249
Query: 836 HCRFRPYACPYAGSECSVTGDIPTLVVHLKDDHK-VDMHDGCTFNHRYVKSN-PHEVENA 663
C +RPY+CP G+ C G + ++ HLK HK + G N P V+
Sbjct: 250 LCEYRPYSCPCPGASCKWQGALADVMDHLKKVHKSITTLQGEDIVFLATDINLPGAVD-- 307
Query: 662 TWMLTVFNCFGRQFCLHFEAFQ----LGMAPVYMAFLRFMGDENEAKKFSYSLEVGAHGR 495
W++ + +CF F L E + ++ A ++ +G + EA F Y LE+ A+ R
Sbjct: 308 -WVM-MQSCFDYNFMLVLEKQEKYDPAQSTQMFYAVVQLIGSKKEADNFVYRLELSANRR 365
Query: 494 KLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFS 387
+++W+ PRSI + D L + A F+
Sbjct: 366 RMSWEATPRSIHEGVAFAIQQSDCLAFDTSAAQLFA 401
>sp|Q965X6|SIAH1_CAEEL E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis
elegans GN=siah-1 PE=1 SV=2
Length = 339
Score = 139 bits (350), Expect = 5e-032
Identities = 81/246 (32%), Positives = 124/246 (50%), Gaps = 11/246 (4%)
Frame = -3
Query: 1106 SNNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYELGNIRCLALEK 927
S+ + + ECPVC M PP QC +GH +CSN + ++Q CPTCR ++R L LEK
Sbjct: 80 SSAEILSVFECPVCLEYMLPPYMQCSSGHLVCSNCRPKLQ-CCPTCRGPTPSVRNLGLEK 138
Query: 926 VAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLK 747
+A ++ PC++ + GC F + K +HE+ C FRPY CP G+ C G + ++ HLK
Sbjct: 139 IANTVRFPCKFSTSGCPLNFHHADKTEHEELCEFRPYCCPCPGASCKWQGGLSDVMEHLK 198
Query: 746 DDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQ----LGMA 585
HK + G N P V+ W++ + +CF F L E +
Sbjct: 199 KIHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFDYNFMLVLEKQEKYDPAQPT 254
Query: 584 PVYMAFLRFMGDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRN 405
++ A ++ +G + EA F Y LE+ A R+++W+ PRSI + D L N
Sbjct: 255 QMFYAVVQLIGSKKEADNFVYRLELSASRRRMSWEATPRSIHEGVVVAIQQSDCLAFDSN 314
Query: 404 LALYFS 387
A F+
Sbjct: 315 AAQLFA 320
>sp|Q7SYL3|SIAH2_DANRE E3 ubiquitin-protein ligase Siah2 OS=Danio rerio
GN=siah2l PE=2 SV=2
Length = 331
Score = 139 bits (349), Expect = 6e-032
Identities = 87/249 (34%), Positives = 129/249 (51%), Gaps = 11/249 (4%)
Frame = -3
Query: 1085 LLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTCRYEL-GNIRCLALEKVAESLE 909
L ECPVC + + PPI QC GH +C+ + ++ + CPTCR L +IR LA+EKVA +L
Sbjct: 86 LFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTCRGPLTPSIRNLAMEKVASTLP 144
Query: 908 VPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSECSVTGDIPTLVVHLKDDHK-V 732
PC+Y S GC + K +HE+ C FRPY CP G+ C G + ++ HL HK +
Sbjct: 145 FPCKYSSAGCLLSLHHSEKPEHEEVCEFRPYTCPCPGASCKWQGSLEEVMPHLMHAHKSI 204
Query: 731 DMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFCLHFEAFQLGMA-PVYMAFLRF 558
G N P V+ W++ + +CFG F L E + + A +
Sbjct: 205 TTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYEGHQQFFAIVLL 260
Query: 557 MGDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGD 378
+G +A+ F+Y LE+ + R+LTW+ PRSI D + D L+ ++A F+ D
Sbjct: 261 IGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTSIAHLFA--D 318
Query: 377 RQELKLRVT 351
L + VT
Sbjct: 319 NGNLGINVT 327
>sp|O43255|SIAH2_HUMAN E3 ubiquitin-protein ligase SIAH2 OS=Homo sapiens
GN=SIAH2 PE=1 SV=1
Length = 324
Score = 136 bits (342), Expect = 4e-031
Identities = 90/270 (33%), Positives = 137/270 (50%), Gaps = 13/270 (4%)
Frame = -3
Query: 1142 SGSAGVGKYGMHS--NNGVYELLECPVCTNLMYPPIHQCPNGHTLCSNRKARVQNTCPTC 969
SG G G G S ++ + L ECPVC + + PPI QC GH +C+ + ++ + CPTC
Sbjct: 56 SGPGGGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTC 114
Query: 968 RYEL-GNIRCLALEKVAESLEVPCRYQSLGCHDIFPYYSKLKHEQHCRFRPYACPYAGSE 792
R L +IR LA+EKVA ++ PC+Y + GC + K +HE C +RPY+CP G+
Sbjct: 115 RGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGAS 174
Query: 791 CSVTGDIPTLVVHLKDDHK-VDMHDGCTFNHRYVKSN-PHEVENATWMLTVFNCFGRQFC 618
C G + ++ HL HK + G N P V+ W++ + +CFG F
Sbjct: 175 CKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFM 230
Query: 617 LHFEAFQLGMA-PVYMAFLRFMGDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKV 441
L E + + A + +G +A+ F+Y LE+ + R+LTW+ PRSI D
Sbjct: 231 LVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAA 290
Query: 440 RDSQDGLIIPRNLALYFSGGDRQELKLRVT 351
+ D L+ +A F+ D L + VT
Sbjct: 291 IMNSDCLVFDTAIAHLFA--DNGNLGINVT 318
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,872,592,117
Number of Sequences: 518415
Number of Extensions: 81872592117
Number of Successful Extensions: 541474699
Number of sequences better than 0.0: 0
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