BLASTX 7.6.2
Query= UN19922 /QuerySize=1684
(1683 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54QP6|OSB8_DICDI Oxysterol-binding protein 8 OS=Dictyosteliu... 240 3e-062
sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c... 221 1e-056
sp|Q54ID7|OSB11_DICDI Oxysterol-binding protein 11 OS=Dictyostel... 215 1e-054
sp|Q8BXR9|OSBL6_MOUSE Oxysterol-binding protein-related protein ... 203 5e-051
sp|Q9BZF3|OSBL6_HUMAN Oxysterol-binding protein-related protein ... 202 7e-051
sp|Q9H4L5|OSBL3_HUMAN Oxysterol-binding protein-related protein ... 202 9e-051
sp|Q9DBS9|OSBL3_MOUSE Oxysterol-binding protein-related protein ... 196 5e-049
sp|Q9BZF2|OSBL7_HUMAN Oxysterol-binding protein-related protein ... 194 2e-048
sp|Q9BXW6|OSBL1_HUMAN Oxysterol-binding protein-related protein ... 175 1e-042
sp|Q8K4M9|OSBL1_RAT Oxysterol-binding protein-related protein 1 ... 174 2e-042
sp|Q91XL9|OSBL1_MOUSE Oxysterol-binding protein-related protein ... 174 2e-042
sp|Q8BX94|OSBL2_MOUSE Oxysterol-binding protein-related protein ... 170 3e-041
sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 OS=Sacc... 155 1e-036
sp|P35845|OSH1_YEAST Oxysterol-binding protein homolog 1 OS=Sacc... 154 2e-036
>sp|Q54QP6|OSB8_DICDI Oxysterol-binding protein 8 OS=Dictyostelium discoideum
GN=osbH PE=1 SV=1
Length = 402
Score = 240 bits (611), Expect = 3e-062
Identities = 142/379 (37%), Positives = 209/379 (55%), Gaps = 12/379 (3%)
Frame = -1
Query: 1464 EEEAQRGRWKDEERDSYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLD 1285
E +G + E+R K + Y+G DITS+++LPV IFEP++ LQ M+E ++Y+ LL
Sbjct: 23 ESGDNKGDIEPEQRKGLLKQLSSYVGKDITSLISLPVWIFEPVSFLQVMSEPLQYNALLS 82
Query: 1284 QADECEDPYLRLVYASSWAISVYFAYQRTWKPFNPILGETYEMAN-HGGISFLSEQVSHH 1108
+A + + +L L Y +++ ++Y RT KPFNPILGET+E+ + G FL+EQVSHH
Sbjct: 83 KASKQDSEFLCLAYLAAFNCALYSTAVRTRKPFNPILGETFEIVDKKGEFRFLAEQVSHH 142
Query: 1107 PPMSAGHAENEHFTYDVTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKVHN 928
PP+ +E +T + + LK+K GNS +V G KK +T HN
Sbjct: 143 PPIGVSETISEDYTLQLETLLKSKFYGNSSEVEIDGTNHFFNKKTNHHYTWNHLVTCCHN 202
Query: 927 LIFGRTWVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGK 748
+I G W+D G++V+ N TTG K VL F GW G+GRY V G + + + + +TGK
Sbjct: 203 IIIGSLWLDHYGDLVIENHTTGSKAVLKFAKSGWLGAGRYGVTGEIVDCEGDVRYRITGK 262
Query: 747 WNEKIS-YQPCDTEGEPLPGTELKEVWHVADVPKNDKFQYTHFAHK--INSFDTAPSKLL 577
WNE I +Q D T L W + P N+KF + + + I+ D L
Sbjct: 263 WNESIQLFQVMDNGSSSTTSTCL---WEASKEPINNKFLFPRWVEENVIDLNDEYKKILP 319
Query: 576 ASDSRLRPDRYALEQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITST 397
+DSRLR DR ALE+G+L A EKH+LEE+QR +KR R + +++ F D+
Sbjct: 320 VTDSRLRADRIALEEGNLDVAAKEKHNLEEKQREDKRQRVAENKEWETAQFKKVDD---A 376
Query: 396 PWGDIEIYQYNGKYNEHRD 340
+G + Y G Y E R+
Sbjct: 377 KFG--YRWNYCGNYWEERE 393
>sp|O14340|YB35_SCHPO Oxysterol-binding protein homolog C2F12.05c
OS=Schizosaccharomyces pombe GN=SPBC2F12.05c PE=1 SV=2
Length = 1310
Score = 221 bits (563), Expect = 1e-056
Identities = 140/374 (37%), Positives = 208/374 (55%), Gaps = 21/374 (5%)
Frame = -1
Query: 1434 DEERDSYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYL 1255
D + S W +++ IG D+T M TLPV EP ++LQ++AE MEY+ LLDQA +DPY
Sbjct: 932 DRPKISLWGILKGMIGKDMTKM-TLPVSFNEPTSLLQRVAEDMEYTELLDQASHNKDPYQ 990
Query: 1254 RLVYASSWAISVYFA-YQRTWKPFNPILGETYEMAN-HGGISFLSEQVSHHPPMSAGHAE 1081
R++Y +++A S Y + R KPFNP+LGETYE + G F+ EQVSHHPP+ A ++E
Sbjct: 991 RILYVAAFAASEYASTLNRVAKPFNPLLGETYEFCHPQRGFRFIVEQVSHHPPVGAAYSE 1050
Query: 1080 NEHFTYDVTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLV---PPLTKVHNLIFGRT 910
+ ++ Y S +K+K G S D+ P+G + L+ ++L + V +I G
Sbjct: 1051 SANWKYYGESSVKSKFYGKSFDISPLGTWFLELRHPSGEVELYTWKKVTSSVVGIILGSP 1110
Query: 909 WVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGKWNEKIS 730
VD+ G+M + N ++G VL F+P GW G+ +EV G V S D+ PK M+ G WN+KI
Sbjct: 1111 SVDNYGQMHIVNHSSGINCVLDFKPRGWRGTNAHEVKGSVQSTDDTPKWMVNGHWNDKIF 1170
Query: 729 YQPCDTEGEPLPGTELKEVWHVADVPKNDKFQYTHFAHKINSFDTAPSKLL-ASDSRLRP 553
Q P +W + P F T FA +N+ L +D+RLRP
Sbjct: 1171 GQQ--------PNGNKILLWQNHERPPR-PFNLTPFAISLNALTPQLKPWLPPTDTRLRP 1221
Query: 552 DRYALEQGDLSKAGSEKHSLEERQRAEKRTRET-KGQKFTPRWFDLTDEITSTPWGDIEI 376
D+ A+E G A SEK+ LEE+QR ++R RE + ++PRWF P +
Sbjct: 1222 DQRAMENGQYDLAASEKNRLEEKQRKKRRMREQGEMPPWSPRWFSAAKH----PVTGEDY 1277
Query: 375 YQYNGKYNEHRDTA 334
+Q+N +Y + R+ A
Sbjct: 1278 WQFNNEYWKIREEA 1291
>sp|Q54ID7|OSB11_DICDI Oxysterol-binding protein 11 OS=Dictyostelium discoideum
GN=osbK PE=3 SV=1
Length = 571
Score = 215 bits (545), Expect = 1e-054
Identities = 119/368 (32%), Positives = 205/368 (55%), Gaps = 10/368 (2%)
Frame = -1
Query: 1431 EERDSYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYLR 1252
E++ S WK + +G D S+V+LPV FEP+T+L+ E + + L+++A C D R
Sbjct: 88 EDKKSLWKKVGGLVGKDPMSLVSLPVYFFEPLTVLECQLEPLRFVELIEKASTCSDSIDR 147
Query: 1251 LVYASSWAISVYFAYQRTWKPFNPILGETYE-MANHGGISFLSEQVSHHPPMSAGHAENE 1075
L+Y +++ I+V+ +Y RT KPFNP+LGET+E + G EQVSHHPP+ +E
Sbjct: 148 LMYLTAFNIAVFSSYTRTAKPFNPLLGETFEYIDKQGRYKSFCEQVSHHPPIGIAQTTSE 207
Query: 1074 HFTYDVTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKVHNLIFGRTWVDSP 895
F S + TK GNS+DV+ G+ + L G P HN+IFG+ W++
Sbjct: 208 IFDLQQESWITTKFWGNSLDVFSHGQNHLYLNSTGEHFTWKVPSAICHNIIFGKMWIEHY 267
Query: 894 GEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGKWNEKISYQPCD 715
G++++ N TG+K ++ FQ GWF + +V G + + ++ + GKW++ + +
Sbjct: 268 GDLIVENHNTGEKAIINFQKSGWFEGTQRKVQGEILDSKGNARVHINGKWDKYVKAKK-H 326
Query: 714 TEGEPLPGTELKEVWHVA-DVPKN-DKFQYTHFAHKINSFDTAPSKLLAS-DSRLRPDRY 544
+EG + +W + P+N +K+++ + +N +L S DSR+R DR
Sbjct: 327 SEGPSRKSSGEITLWEATIEPPENFNKWKHGKWIQGLNEMSKEYQAVLPSTDSRVRMDRI 386
Query: 543 ALEQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITSTPWGDIEIYQYN 364
LE+ + A EK+ +EER+R +++TRE++ + + P +F ++ + +G + +N
Sbjct: 387 YLEREENKLANKEKNKIEEREREKRKTRESRKEIWKPNYFSKRED---SKYG--YRWDFN 441
Query: 363 GKYNEHRD 340
GKY + RD
Sbjct: 442 GKYWDERD 449
>sp|Q8BXR9|OSBL6_MOUSE Oxysterol-binding protein-related protein 6 OS=Mus
musculus GN=Osbpl6 PE=2 SV=1
Length = 959
Score = 203 bits (514), Expect = 5e-051
Identities = 126/346 (36%), Positives = 191/346 (55%), Gaps = 21/346 (6%)
Frame = -1
Query: 1434 DEERDSYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYL 1255
D + W +++ IG D+ S V++PV + EP+ LQ + E MEYS LLD+A E +DPY
Sbjct: 590 DTSNINLWNILRNNIGKDL-SKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYE 648
Query: 1254 RLVYASSWAISVYFA--YQRTWKPFNPILGETYE-MANHGGISFLSEQVSHHPPMSAGHA 1084
R+V +++A+S Y + ++ KPFNP+LGETYE + G F SEQVSHHPP+SA H
Sbjct: 649 RMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHC 708
Query: 1083 ENEHFTYDVTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKVHNLIFGRTWV 904
E+++F + + K K G S+++ PVG VTL K G T +HN++ GR W+
Sbjct: 709 ESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVTLPKYGDYYVWNKVTTCIHNILSGRRWI 768
Query: 903 DSPGEMVMTNLTTGDKVV-LYFQPCGWFGSGRYEVDGYVYSADEEPKIM--MTGKWNEKI 733
+ GE+ + N + + L F ++ S EV G V D+E K++ + GKW+E +
Sbjct: 769 EHYGEVTLRNTKSSVCICKLTFVKVNYWNSNVNEVQGVV--IDQEGKVVHRLFGKWHEGL 826
Query: 732 SYQPCDTEGEPLPGTELKEVWHVADVPKNDKFQY--THFAHKINSFDTAPSKLL-ASDSR 562
C K +W +P N + Y T FA ++N D LL +D+R
Sbjct: 827 Y---CGV------APSAKCIWRPGSLPTNYELYYGFTRFAVELNELDPVLKDLLPPTDAR 877
Query: 561 LRPDRYALEQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWF 424
RPD+ LE+G+L A +EK +EE QR+ +R E + P++F
Sbjct: 878 FRPDQRFLEEGNLEAAAAEKQRVEELQRSRRRYMEENNLEHIPKFF 923
>sp|Q9BZF3|OSBL6_HUMAN Oxysterol-binding protein-related protein 6 OS=Homo
sapiens GN=OSBPL6 PE=1 SV=1
Length = 934
Score = 202 bits (513), Expect = 7e-051
Identities = 123/344 (35%), Positives = 186/344 (54%), Gaps = 17/344 (4%)
Frame = -1
Query: 1434 DEERDSYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYL 1255
D + W +++ IG D+ S V++PV + EP+ LQ + E MEYS LLD+A E +DPY
Sbjct: 565 DTSNINLWNILRNNIGKDL-SKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYE 623
Query: 1254 RLVYASSWAISVYFA--YQRTWKPFNPILGETYE-MANHGGISFLSEQVSHHPPMSAGHA 1084
R+V +++A+S Y + ++ KPFNP+LGETYE + G F SEQVSHHPP+SA H
Sbjct: 624 RMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHC 683
Query: 1083 ENEHFTYDVTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKVHNLIFGRTWV 904
E+++F + + K K G S+++ PVG V L K G T +HN++ GR W+
Sbjct: 684 ESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWI 743
Query: 903 DSPGEMVMTNLTTGDKVV-LYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGKWNEKISY 727
+ GE+ + N + + L F ++ S EV G V + + + GKW+E +
Sbjct: 744 EHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLY- 802
Query: 726 QPCDTEGEPLPGTELKEVWHVADVPKNDKFQY--THFAHKINSFDTAPSKLL-ASDSRLR 556
C K +W +P N + Y T FA ++N D LL +D+R R
Sbjct: 803 --CGV------APSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFR 854
Query: 555 PDRYALEQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWF 424
PD+ LE+G+L A SEK +EE QR+ +R E + P++F
Sbjct: 855 PDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFF 898
>sp|Q9H4L5|OSBL3_HUMAN Oxysterol-binding protein-related protein 3 OS=Homo
sapiens GN=OSBPL3 PE=1 SV=1
Length = 887
Score = 202 bits (512), Expect = 9e-051
Identities = 120/344 (34%), Positives = 191/344 (55%), Gaps = 17/344 (4%)
Frame = -1
Query: 1419 SYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYLRLVYA 1240
S W +++ IG D+ S V +PV + EP+ LQ++ E +EYS LLD+A + P R+VY
Sbjct: 527 SLWNILRNNIGKDL-SKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYV 585
Query: 1239 SSWAISVYFA--YQRTWKPFNPILGETYE-MANHGGISFLSEQVSHHPPMSAGHAENEHF 1069
+++AIS Y + Y+ KPFNP+LGETYE + G F SEQVSHHPP+SA HAE+ +F
Sbjct: 586 AAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQFFSEQVSHHPPISACHAESRNF 645
Query: 1068 TYDVTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKVHNLIFGRTWVDSPGE 889
+ + K K G S+++ P+G T VTL G + + +HN++ G+ W++ GE
Sbjct: 646 VFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGE 705
Query: 888 MVMTNLTTGD-KVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGKWNEKISYQPCDT 712
+V+ NL + F ++ + +E++G V+ + + GKW+E I C
Sbjct: 706 IVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIY---CG- 761
Query: 711 EGEPLPGTELKEVWHVADVPK--NDKFQYTHFAHKINSFDTAPSKLL-ASDSRLRPDRYA 541
G+ VW +PK + +T FA ++N D + LL +D+R RPD+
Sbjct: 762 -----GGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRF 816
Query: 540 LEQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDE 409
LE+G+L +A +K +E+ QR +R E + PR+F +D+
Sbjct: 817 LEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRKSDD 860
>sp|Q9DBS9|OSBL3_MOUSE Oxysterol-binding protein-related protein 3 OS=Mus
musculus GN=Osbpl3 PE=1 SV=1
Length = 855
Score = 196 bits (497), Expect = 5e-049
Identities = 117/344 (34%), Positives = 185/344 (53%), Gaps = 27/344 (7%)
Frame = -1
Query: 1419 SYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYLRLVYA 1240
S W +++ IG D+ S V +PV + EP+ LQ++ E +EYS LLD+A P R+VY
Sbjct: 495 SLWSILRNNIGKDL-SKVAMPVELNEPLNTLQRLCEELEYSELLDKASRIPSPLERMVYV 553
Query: 1239 SSWAISVYFA--YQRTWKPFNPILGETYE-MANHGGISFLSEQVSHHPPMSAGHAENEHF 1069
+++AIS Y + ++ KPFNP+LGETYE + G F +EQVSHHPP+SA HAE+ +F
Sbjct: 554 AAFAISAYASSYFRAGSKPFNPVLGETYECIRQDKGFQFFAEQVSHHPPISACHAESGNF 613
Query: 1068 TYDVTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKVHNLIFGRTWVDSPGE 889
+ + K K G S+++ P+G T VTL G + + +HN++ G+ W++ GE
Sbjct: 614 VFWQDVRWKNKFWGKSMEIVPIGTTHVTLPAFGDHFEWNKVTSCIHNILSGQRWIEHYGE 673
Query: 888 MVMTNLTTGD-KVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGKWNEKI-----SY 727
+ + NL + F ++ + +E++G V+ + + GKW+E I S
Sbjct: 674 IDIKNLNDDSCHCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCGGASS 733
Query: 726 QPCDTEGEPLPGTELKEVWHVADVPK--NDKFQYTHFAHKINSFDTAPSKLL-ASDSRLR 556
C VW +PK + +T FA ++N D LL +D+R R
Sbjct: 734 STC--------------VWRANPMPKGYEQYYGFTQFALELNEMDPLSRSLLPPTDTRFR 779
Query: 555 PDRYALEQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWF 424
PD+ LE+GD+ +A +K +E+ QR +R E G + PR+F
Sbjct: 780 PDQRLLEEGDIEEAEVQKQRIEKLQRERRRVLEENGVEHQPRFF 823
>sp|Q9BZF2|OSBL7_HUMAN Oxysterol-binding protein-related protein 7 OS=Homo
sapiens GN=OSBPL7 PE=2 SV=1
Length = 842
Score = 194 bits (492), Expect = 2e-048
Identities = 121/350 (34%), Positives = 191/350 (54%), Gaps = 17/350 (4%)
Frame = -1
Query: 1419 SYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYLRLVYA 1240
S W +++ IG D+ S V++PV + EP+ LQ++ E +EYS LLDQA DP R+VY
Sbjct: 478 SLWNILRNNIGKDL-SKVSMPVQLNEPLNTLQRLCEELEYSSLLDQASRIADPCERMVYI 536
Query: 1239 SSWAISVYFA-YQRT-WKPFNPILGETYEMAN-HGGISFLSEQVSHHPPMSAGHAENEHF 1069
+++A+S Y + Y R KPFNP+LGETYE G F+SEQVSHHPP+SA HAE+E+F
Sbjct: 537 AAFAVSAYSSTYHRAGCKPFNPVLGETYECERPDRGFRFISEQVSHHPPISACHAESENF 596
Query: 1068 TYDVTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKVHNLIFGRTWVDSPGE 889
+ K K K G S+++ PVG V+L + G + + +HN++ G+ W++ GE
Sbjct: 597 AFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGE 656
Query: 888 MVMTNLTTGD-KVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGKWNEKISYQPCDT 712
+++ N + F ++ S +EV G V S + GKW+E + Y+
Sbjct: 657 VLIRNTQDSSCHCKITFCKAKYWSSNVHEVQGAVLSRSGRVLHRLFGKWHEGL-YR---- 711
Query: 711 EGEPLPGTELKEVWHVADVPKNDK--FQYTHFAHKINSFDTAPSKLLAS-DSRLRPDRYA 541
P PG + +W +P + + F +T FA ++N + L S D+RLRPD+
Sbjct: 712 --GPTPGGQC--IWKPNSMPPDHERNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRY 767
Query: 540 LEQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITSTPW 391
LE+G++ A ++K +E+ QR ++ E R+F + + W
Sbjct: 768 LEEGNIQAAEAQKRRIEQLQRDRRKVMEENNIVHQARFFRRQTDSSGKEW 817
>sp|Q9BXW6|OSBL1_HUMAN Oxysterol-binding protein-related protein 1 OS=Homo
sapiens GN=OSBPL1A PE=1 SV=2
Length = 950
Score = 175 bits (442), Expect = 1e-042
Identities = 92/231 (39%), Positives = 137/231 (59%), Gaps = 5/231 (2%)
Frame = -1
Query: 1419 SYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYLRLVYA 1240
S W +++K IG ++ S +T+PVI EP++ LQ++ E ME++YL+ +A DP R+
Sbjct: 548 SIWSILRKCIGMEL-SKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCV 606
Query: 1239 SSWAIS-VYFAYQRTWKPFNPILGETYEMANHG-GISFLSEQVSHHPPMSAGHAE--NEH 1072
+++A+S V ++RT KPFNP+LGETYE+ G +SEQVSHHPP+SA HAE N
Sbjct: 607 AAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNND 666
Query: 1071 FTYDVTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKVHNLIFGRTWVDSPG 892
F + + K K G SV+ P G + L + P VHN+I G+ W++ G
Sbjct: 667 FIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYG 726
Query: 891 EMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGKWNE 739
+ + N TGDK VL F+PCG FG ++V+GY+ ++ + GKW E
Sbjct: 727 NVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTE 777
Score = 65 bits (156), Expect = 2e-009
Identities = 39/118 (33%), Positives = 61/118 (51%), Gaps = 9/118 (7%)
Frame = -1
Query: 699 LPGTELKEVWHVADVPKN--DKFQYTHFAHKINSFD-TAPSKLLASDSRLRPDRYALEQG 529
+PG+ L +W +A P N + +T FA +N D S + +D RLRPD A+E G
Sbjct: 827 IPGSVL--LWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENG 884
Query: 528 DLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITSTPWGDIEIYQYNGKY 355
++ +A EK LEE+QRA ++ R + + RWF P+ + + Y+G Y
Sbjct: 885 EIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWF----HQGPNPYNGAQDWIYSGSY 938
>sp|Q8K4M9|OSBL1_RAT Oxysterol-binding protein-related protein 1 OS=Rattus
norvegicus GN=Osbpl1a PE=1 SV=1
Length = 950
Score = 174 bits (441), Expect = 2e-042
Identities = 92/231 (39%), Positives = 137/231 (59%), Gaps = 5/231 (2%)
Frame = -1
Query: 1419 SYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYLRLVYA 1240
S W +++K IG ++ S +T+PVI EP++ LQ++ E ME++YL+ +A DP R+
Sbjct: 548 SIWSILRKCIGMEL-SKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSFSDPVERMQCV 606
Query: 1239 SSWAIS-VYFAYQRTWKPFNPILGETYEMANHG-GISFLSEQVSHHPPMSAGHAE--NEH 1072
+++A+S V ++RT KPFNP+LGETYE+ G +SEQVSHHPP+SA HAE N
Sbjct: 607 AAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNND 666
Query: 1071 FTYDVTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKVHNLIFGRTWVDSPG 892
F + + K K G SV+ P G + L + P VHN+I G+ W++ G
Sbjct: 667 FIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYG 726
Query: 891 EMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGKWNE 739
+ + N TGDK VL F+PCG FG ++V+GY+ ++ + GKW E
Sbjct: 727 NVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTE 777
Score = 65 bits (158), Expect = 1e-009
Identities = 45/146 (30%), Positives = 71/146 (48%), Gaps = 11/146 (7%)
Frame = -1
Query: 777 EEPKIMMTGKWNEKISYQPC-DTEGE-PLPGTELKEVWHVADVPKN--DKFQYTHFAHKI 610
EE K +E+ P D+E +PG+ L +W +A P N + +T FA +
Sbjct: 799 EEKKTSKQASTSEESDEMPVPDSESVFVIPGSAL--LWRIAPRPPNSAQMYNFTSFAMVL 856
Query: 609 NSFDTAPSKLL-ASDSRLRPDRYALEQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTP 433
N D ++ +D RLRPD A+E G++ +A EK LEE+QRA ++ R + +
Sbjct: 857 NEVDKEMETVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKT 916
Query: 432 RWFDLTDEITSTPWGDIEIYQYNGKY 355
RWF P+ + + Y+G Y
Sbjct: 917 RWF----HQGPNPYSGAQDWIYSGSY 938
>sp|Q91XL9|OSBL1_MOUSE Oxysterol-binding protein-related protein 1 OS=Mus
musculus GN=Osbpl1a PE=1 SV=2
Length = 950
Score = 174 bits (440), Expect = 2e-042
Identities = 92/231 (39%), Positives = 136/231 (58%), Gaps = 5/231 (2%)
Frame = -1
Query: 1419 SYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYLRLVYA 1240
S W +++K IG ++ S +T+PVI EP++ LQ++ E ME++YL+ +A DP R+
Sbjct: 548 SIWSILRKCIGMEL-SKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCV 606
Query: 1239 SSWAIS-VYFAYQRTWKPFNPILGETYEMANHG-GISFLSEQVSHHPPMSAGHAE--NEH 1072
+++A+S V ++RT KPFNP+LGETYE+ G +SEQVSHHPP+SA HAE N
Sbjct: 607 AAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNND 666
Query: 1071 FTYDVTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKVHNLIFGRTWVDSPG 892
F + + K K G SV+ P G + L P VHN+I G+ W++ G
Sbjct: 667 FIFHGSIYPKLKFWGKSVEAEPKGTITLELLDHNEAYTWTNPTCCVHNIIVGKLWIEQYG 726
Query: 891 EMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGKWNE 739
+ + N TGDK VL F+PCG FG ++V+GY+ ++ + GKW E
Sbjct: 727 NVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTE 777
>sp|Q8BX94|OSBL2_MOUSE Oxysterol-binding protein-related protein 2 OS=Mus
musculus GN=Osbpl2 PE=2 SV=1
Length = 484
Score = 170 bits (430), Expect = 3e-041
Identities = 89/231 (38%), Positives = 137/231 (59%), Gaps = 5/231 (2%)
Frame = -1
Query: 1419 SYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYLRLVYA 1240
S W +++K IG ++ S +T+P+ EP++ LQ++ E ME+ YL+ +A P R+
Sbjct: 75 SVWSILKKCIGLEL-SKITMPIAFNEPLSFLQRITEYMEHVYLIHKASSQSQPLERMQSV 133
Query: 1239 SSWAIS-VYFAYQRTWKPFNPILGETYEMANHG-GISFLSEQVSHHPPMSAGHAE--NEH 1072
+++A+S V ++RT KPFNP+LGETYE+ G F+SEQVSHHPP+SA ++E N+
Sbjct: 134 AAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFYSEGLNQD 193
Query: 1071 FTYDVTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVVLDLVPPLTKVHNLIFGRTWVDSPG 892
F + + K K G SV+ P G + L K P VHN+I G+ W++ G
Sbjct: 194 FRFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVILGQLWIEQYG 253
Query: 891 EMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGKWNE 739
+ + N TGDK +L+F+PCG FG + V+GY+ + + +M GKW E
Sbjct: 254 IVEIVNHRTGDKCILHFKPCGLFGKELHRVEGYIQDKNRKKLFIMYGKWTE 304
>sp|Q12451|OSH2_YEAST Oxysterol-binding protein homolog 2 OS=Saccharomyces
cerevisiae GN=OSH2 PE=1 SV=1
Length = 1283
Score = 155 bits (390), Expect = 1e-036
Identities = 95/250 (38%), Positives = 141/250 (56%), Gaps = 7/250 (2%)
Frame = -1
Query: 1434 DEERDSYWKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYL 1255
D + S W +++ +G D+T M TLPV EP ++LQ++AE +EYS LLDQA ED L
Sbjct: 892 DRPKISLWAVLKSMVGKDMTRM-TLPVTFNEPTSLLQRVAEDLEYSELLDQAATFEDSTL 950
Query: 1254 RLVYASSWAISVYFA-YQRTWKPFNPILGETYEMAN-HGGISFLSEQVSHHPPMSAGHAE 1081
R +Y +++ S Y + +R KPFNP+LGET+E + F +EQVSHHPP+SA E
Sbjct: 951 RTLYVAAFTASSYASTTKRVAKPFNPLLGETFEYSRPDKQYRFFTEQVSHHPPISATWTE 1010
Query: 1080 NEHFTYDVTSKLKTKLLGNSVDVYPVGRTRVTLK-KDGVVLDLV---PPLTKVHNLIFGR 913
+ + + S + TK G S +V +G + L+ D +L P V ++ G
Sbjct: 1011 SPRWDFWGESFVDTKFNGRSFNVKHLGLWHIKLRPNDNEKEELYTWKKPNNTVIGILIGN 1070
Query: 912 TWVDSPGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGKWNEKI 733
VD+ GE+ + N TTGD LYF+ GW SG YE+ G VY+ ++ ++ G WNE I
Sbjct: 1071 PQVDNHGEVNVVNHTTGDHCKLYFKARGWRSSGAYEITGEVYNKKKQKVWILGGHWNEAI 1130
Query: 732 SYQPCDTEGE 703
+ +G+
Sbjct: 1131 FAKKVVKDGD 1140
Score = 64 bits (153), Expect = 4e-009
Identities = 42/113 (37%), Positives = 60/113 (53%), Gaps = 16/113 (14%)
Frame = -1
Query: 675 VWHVADVPKNDKFQYTHFAHKINSFDTAPSK-----LLASDSRLRPDRYALEQGDLSKAG 511
+W D P+ + F T FA +N AP L +D+RLRPD+ A+E G +AG
Sbjct: 1165 IWKANDRPE-EPFNLTPFAITLN----APQPHLLPWLPPTDTRLRPDQRAMEDGRYDEAG 1219
Query: 510 SEKHSLEERQRAEKRTRETKGQKFTPRWFDL-TDEITSTPWGDIEIYQYNGKY 355
EK +EE+QRA +R RE ++ P+WF T IT + ++Y GKY
Sbjct: 1220 DEKFRVEEKQRAARRKREENNLEYHPQWFVRDTHPITKAKY-----WRYTGKY 1267
>sp|P35845|OSH1_YEAST Oxysterol-binding protein homolog 1 OS=Saccharomyces
cerevisiae GN=OSH1 PE=1 SV=4
Length = 1188
Score = 154 bits (389), Expect = 2e-036
Identities = 89/265 (33%), Positives = 146/265 (55%), Gaps = 9/265 (3%)
Frame = -1
Query: 1413 WKMMQKYIGSDITSMVTLPVIIFEPMTMLQKMAELMEYSYLLDQADECEDPYLRLVYASS 1234
W +++ +G D+T + TLPV EP ++LQ+++E +EYS++LDQA ED LR++Y ++
Sbjct: 801 WSVLKSMVGQDLTKL-TLPVSFNEPTSLLQRVSEDIEYSHILDQAATFEDSSLRMLYVAA 859
Query: 1233 WAISVYFA-YQRTWKPFNPILGETYEMA-NHGGISFLSEQVSHHPPMSAGHAENEHFTYD 1060
+ S+Y + R KPFNP+LGET+E A G F +EQVSHHPP+SA E+ + +
Sbjct: 860 FTASMYASTTNRVSKPFNPLLGETFEYARTDGQYRFFTEQVSHHPPISATWTESPKWDFY 919
Query: 1059 VTSKLKTKLLGNSVDVYPVGRTRVTLKKDGVV------LDLVPPLTKVHNLIFGRTWVDS 898
+ + G + V +G +T++ D + P V ++ G+ VD+
Sbjct: 920 GECNVDSSFNGRTFAVQHLGLWYITIRPDHNISVPEETYSWKKPNNTVIGILMGKPQVDN 979
Query: 897 PGEMVMTNLTTGDKVVLYFQPCGWFGSGRYEVDGYVYSADEEPKIMMTGKWNEKISYQPC 718
G++ +TN TTGD +L+++ GW +G YEV G V++ D++ ++ G WN+ I +
Sbjct: 980 SGDVKVTNHTTGDYCMLHYKAHGWTSAGAYEVRGEVFNKDDKKLWVLGGHWNDSIYGKKV 1039
Query: 717 DTEGEPLPGTELKEVWHVADVPKND 643
G L +K PK D
Sbjct: 1040 TARGGELTLDRIKTANSATGGPKLD 1064
Score = 72 bits (175), Expect = 1e-011
Identities = 44/121 (36%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Frame = -1
Query: 714 TEGEPLPGTELKEVWHVADVPKNDKFQYTHFAHKINSFDTAPSKLLA-SDSRLRPDRYAL 538
T G L G++ +W + P + F T FA +N+ LA +DSRLRPD+ A+
Sbjct: 1058 TGGPKLDGSKFL-IWKANERP-SVPFNLTSFALTLNALPPHLIPYLAPTDSRLRPDQRAM 1115
Query: 537 EQGDLSKAGSEKHSLEERQRAEKRTRETKGQKFTPRWFDLTDEITSTPWGDIEIYQYNGK 358
E G+ KA +EKH +E +QRA K+ RE KG+++ P+WF + P +++NG+
Sbjct: 1116 ENGEYDKAAAEKHRVEVKQRAAKKEREQKGEEYRPKWFVQEEH----PVTKSLYWKFNGE 1171
Query: 357 Y 355
Y
Sbjct: 1172 Y 1172
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,872,592,117
Number of Sequences: 518415
Number of Extensions: 81872592117
Number of Successful Extensions: 541474699
Number of sequences better than 0.0: 0
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