BLASTX 7.6.2
Query= UN19994 /QuerySize=1255
(1254 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|A6QP05|DHR12_BOVIN Dehydrogenase/reductase SDR family member ... 255 5e-067
sp|A0PJE2|DHR12_HUMAN Dehydrogenase/reductase SDR family member ... 250 2e-065
sp|Q8TC12|RDH11_HUMAN Retinol dehydrogenase 11 OS=Homo sapiens G... 156 3e-037
sp|Q9QYF1|RDH11_MOUSE Retinol dehydrogenase 11 OS=Mus musculus G... 152 7e-036
sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 OS=Bos taurus GN=... 144 1e-033
sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 OS=Homo sapiens G... 143 3e-033
sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 OS=Mus musculus G... 136 3e-031
sp|Q8CEE7|RDH13_MOUSE Retinol dehydrogenase 13 OS=Mus musculus G... 128 1e-028
sp|Q17QU7|DHR13_BOVIN Dehydrogenase/reductase SDR family member ... 125 1e-027
sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 OS=Homo sapiens G... 124 1e-027
sp|Q5SS80|DHR13_MOUSE Dehydrogenase/reductase SDR family member ... 123 4e-027
sp|Q9ERI6|RDH14_MOUSE Retinol dehydrogenase 14 OS=Mus musculus G... 122 5e-027
sp|Q6UX07|DHR13_HUMAN Dehydrogenase/reductase SDR family member ... 121 1e-026
sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gall... 114 1e-024
sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pong... 114 2e-024
sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo... 113 4e-024
sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member ... 112 7e-024
sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Dani... 110 2e-023
sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus ... 107 3e-022
sp|Q8VBZ0|DHRSX_MOUSE Dehydrogenase/reductase SDR family member ... 100 3e-020
>sp|A6QP05|DHR12_BOVIN Dehydrogenase/reductase SDR family member 12 OS=Bos
taurus GN=DHRS12 PE=2 SV=1
Length = 317
Score = 255 bits (651), Expect = 5e-067
Identities = 140/314 (44%), Positives = 191/314 (60%), Gaps = 6/314 (1%)
Frame = -3
Query: 1144 WRSTAFGIYGYMNFTKNGFLDHSKKFKPEDMQIQIQGKNCVVTGANSGIGYAAAEGLASR 965
+RS A+ G +TK+G+ SK F P+D+++Q+ G+ +VTG NSGIG A A +A R
Sbjct: 4 YRSAAWFAKGLREYTKSGYESASKDFVPDDLEVQVPGRAFMVTGGNSGIGKATAMEIAKR 63
Query: 964 GANVYMVCRNKERGEEALSKIQNSTGNQNVYLEVCDLSSVNDIKSFASTFASKDVPVHVL 785
G V++VCR+ R E A ++I +GNQN++L + DLS + F F ++ ++VL
Sbjct: 64 GGTVHLVCRDHSRAEGAKAEIIRESGNQNIFLHIVDLSLPKSVWKFVENF-KQEHTLNVL 122
Query: 784 VNNAGLLENKRTTTPEGFELNFAINVLGTYTMTELMLPLLEKASPDSKVITVSSGGMYTS 605
+NNAG + NKR T +G E NFA N LG Y +T ++P+LEK D +VITVSSGGM
Sbjct: 123 INNAGCMVNKRELTEDGLEKNFATNTLGVYVLTTALIPVLEK-EHDPRVITVSSGGMLVQ 181
Query: 604 PLTT-DLQFSGEKFDGVLQYARNKRIQVALTEKWADKYKNKGIGFYSMHPGWAETPGVAR 428
L T D Q FDG + YA+NKR QV LTE+WA + I F MHPGW +TPGV
Sbjct: 182 KLNTDDPQSERTAFDGTMVYAQNKRQQVVLTERWARAH--PAIHFSCMHPGWVDTPGVRL 239
Query: 427 SLPSFKESFSGKLRTSEEGADTVVWLALQPKEKL-VSGAFYFDRAEAPKHLTLAGTSKSH 251
S+P F +LR+ +GADTV+WLAL P SG F+ DR AP HL LA TS S
Sbjct: 240 SMPGFHARLGARLRSEAQGADTVLWLALAPAATAQPSGCFFQDRKPAPTHLPLARTSSSP 299
Query: 250 DLIDAVIDSVHSMA 209
+ +I+ + +A
Sbjct: 300 AEEEKLIEILEELA 313
>sp|A0PJE2|DHR12_HUMAN Dehydrogenase/reductase SDR family member 12 OS=Homo
sapiens GN=DHRS12 PE=2 SV=2
Length = 317
Score = 250 bits (637), Expect = 2e-065
Identities = 138/317 (43%), Positives = 190/317 (59%), Gaps = 6/317 (1%)
Frame = -3
Query: 1153 LKTWRSTAFGIYGYMNFTKNGFLDHSKKFKPEDMQIQIQGKNCVVTGANSGIGYAAAEGL 974
+ +RS + G +TK+G+ K F P D+++QI G+ +VTG NSGIG A A +
Sbjct: 1 MSLYRSVVWFAKGLREYTKSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEI 60
Query: 973 ASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYLEVCDLSSVNDIKSFASTFASKDVPV 794
A RG V++VCR++ E+A +I +GNQN++L + DLS I F F ++ +
Sbjct: 61 AKRGGTVHLVCRDQAPAEDARGEIIRESGNQNIFLHIVDLSDPKQIWKFVENF-KQEHKL 119
Query: 793 HVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTMTELMLPLLEKASPDSKVITVSSGGM 614
HVL+NNAG + NKR T +G E NFA N LG Y +T ++P+LEK D +VITVSSGGM
Sbjct: 120 HVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEK-EHDPRVITVSSGGM 178
Query: 613 YTSPL-TTDLQFSGEKFDGVLQYARNKRIQVALTEKWADKYKNKGIGFYSMHPGWAETPG 437
L T DLQ FDG + YA+NKR QV LTE+WA + I F SMHPGWA+TPG
Sbjct: 179 LVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGH--PAIHFSSMHPGWADTPG 236
Query: 436 VARSLPSFKESFSGKLRTSEEGADTVVWLALQPKEKL-VSGAFYFDRAEAPKHLTLAGTS 260
V +++P F F +LR+ +GADT++WLAL SG F+ DR HL LA S
Sbjct: 237 VRQAMPGFHARFGDRLRSEAQGADTMLWLALSSAAAAQPSGRFFQDRKPVSTHLPLATAS 296
Query: 259 KSHDLIDAVIDSVHSMA 209
S + +I+ + +A
Sbjct: 297 SSPAEEEKLIEILEQLA 313
>sp|Q8TC12|RDH11_HUMAN Retinol dehydrogenase 11 OS=Homo sapiens GN=RDH11 PE=1
SV=2
Length = 318
Score = 156 bits (394), Expect = 3e-037
Identities = 93/254 (36%), Positives = 148/254 (58%), Gaps = 9/254 (3%)
Frame = -3
Query: 1048 IQIQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYL 869
+Q+ GK VVTGAN+GIG A+ LA RGA VY+ CR+ E+GE +IQ +TGNQ V +
Sbjct: 37 VQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLV 96
Query: 868 EVCDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTM 689
DLS I++FA F +++ +HVL+NNAG++ + T +GFE++ +N LG + +
Sbjct: 97 RKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLL 156
Query: 688 TELMLPLLEKASPDSKVITVSSGGMYTSPLTTDLQFSGEKF-DGVLQYARNKRIQVALTE 512
T L+L L++++P S+++ VSS + + GEKF + L Y +K + T+
Sbjct: 157 THLLLEKLKESAP-SRIVNVSSLAHHLGRIHFH-NLQGEKFYNAGLAYCHSKLANILFTQ 214
Query: 511 KWADKYKNKGIGFYSMHPGWAETPGVARSLPSFKE----SFSGKLRTSEEGADTVVWLAL 344
+ A + K G+ YS+HPG ++ V S SF FS ++T ++GA T + AL
Sbjct: 215 ELARRLKGSGVTTYSVHPGTVQSELVRHS--SFMRWMWWLFSFFIKTPQQGAQTSLHCAL 272
Query: 343 QPKEKLVSGAFYFD 302
+++SG + D
Sbjct: 273 TEGLEILSGNHFSD 286
>sp|Q9QYF1|RDH11_MOUSE Retinol dehydrogenase 11 OS=Mus musculus GN=Rdh11 PE=2
SV=2
Length = 316
Score = 152 bits (382), Expect = 7e-036
Identities = 86/252 (34%), Positives = 147/252 (58%), Gaps = 5/252 (1%)
Frame = -3
Query: 1048 IQIQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYL 869
+Q+ GK +VTGAN+GIG A+ LA RGA VY+ CR+ ++GE A +IQ TGN V++
Sbjct: 34 VQLPGKVAIVTGANTGIGKETAKDLAQRGARVYLACRDVDKGELAAREIQAVTGNSQVFV 93
Query: 868 EVCDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTM 689
DL+ I++FA F +++ +H+L+NNAG++ + T +GFE++ +N LG + +
Sbjct: 94 RKLDLADTKSIRAFAKDFLAEEKHLHLLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLL 153
Query: 688 TELMLPLLEKASPDSKVITVSSGGMYTSPLTTDLQFSGEKF-DGVLQYARNKRIQVALTE 512
T L+L L++++P S+++ +SS G + + GEKF L Y +K + T+
Sbjct: 154 THLLLEKLKESAP-SRIVNLSSLGHHLGRIHFH-NLQGEKFYSAGLAYCHSKLANILFTK 211
Query: 511 KWADKYKNKGIGFYSMHPG--WAETPGVARSLPSFKESFSGKLRTSEEGADTVVWLALQP 338
+ A + K G+ YS+HPG +E + + + F ++T +EGA T ++ AL
Sbjct: 212 ELAKRLKGSGVTTYSVHPGTVHSELTRYSSIMRWLWQLFFVFIKTPQEGAQTSLYCALTE 271
Query: 337 KEKLVSGAFYFD 302
+ +SG+ + D
Sbjct: 272 GLESLSGSHFSD 283
>sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 OS=Bos taurus GN=RDH12 PE=2
SV=1
Length = 316
Score = 144 bits (363), Expect = 1e-033
Identities = 91/253 (35%), Positives = 144/253 (56%), Gaps = 7/253 (2%)
Frame = -3
Query: 1048 IQIQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYL 869
+Q+ GK V+TGAN+GIG A LA RGA VY+ CR+ +GE A S+IQ T N V +
Sbjct: 35 VQLFGKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIQADTKNSQVLV 94
Query: 868 EVCDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTM 689
DLS I++FA F +++ +H+L+NNAG++ + T +GFE + A+N LG + +
Sbjct: 95 RKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMLCPYSKTADGFETHLAVNHLGHFLL 154
Query: 688 TELMLPLLEKASPDSKVITVSSGGMYTSPLT-TDLQFSGEKFDGV-LQYARNKRIQVALT 515
T L+L L++++P ++V+ +SS + + DLQ G+K+ + Y +K V T
Sbjct: 155 THLLLGRLKESAP-ARVVNLSSVAHHLGKIRFHDLQ--GDKYYNLGFAYCHSKLANVLFT 211
Query: 514 EKWADKYKNKGIGFYSMHPGWAETPGVARS--LPSFKESFSGKLRTSEEGADTVVWLALQ 341
+ A + K G+ Y++HPG + V S L FS L+T+ EGA T + AL
Sbjct: 212 RELAKRLKGTGVTTYAVHPGIVRSKLVRHSFLLCLLWRLFSPFLKTTWEGAQTSLHCALA 271
Query: 340 PKEKLVSGAFYFD 302
+ +SG ++ D
Sbjct: 272 EGLEPLSGKYFSD 284
>sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 OS=Homo sapiens GN=RDH12 PE=1
SV=3
Length = 316
Score = 143 bits (359), Expect = 3e-033
Identities = 88/252 (34%), Positives = 142/252 (56%), Gaps = 5/252 (1%)
Frame = -3
Query: 1048 IQIQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYL 869
+Q+ GK V+TGAN+GIG A LASRGA VY+ CR+ +GE A S+I+ T N V +
Sbjct: 35 VQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLV 94
Query: 868 EVCDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTM 689
DLS I++FA F +++ +H+L+NNAG++ + T +GFE + +N LG + +
Sbjct: 95 RKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLL 154
Query: 688 TELMLPLLEKASPDSKVITVSSGGMYTSPLT-TDLQFSGEKFDGVLQYARNKRIQVALTE 512
T L+L L+ ++P ++V+ VSS + + DLQ S +++ Y +K V T
Sbjct: 155 TYLLLERLKVSAP-ARVVNVSSVAHHIGKIPFHDLQ-SEKRYSRGFAYCHSKLANVLFTR 212
Query: 511 KWADKYKNKGIGFYSMHPGWAETPGVARS--LPSFKESFSGKLRTSEEGADTVVWLALQP 338
+ A + + G+ Y++HPG + V S L FS ++T+ EGA T + AL
Sbjct: 213 ELAKRLQGTGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAE 272
Query: 337 KEKLVSGAFYFD 302
+ +SG ++ D
Sbjct: 273 GLEPLSGKYFSD 284
>sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 OS=Mus musculus GN=Rdh12 PE=2
SV=1
Length = 316
Score = 136 bits (342), Expect = 3e-031
Identities = 83/252 (32%), Positives = 140/252 (55%), Gaps = 5/252 (1%)
Frame = -3
Query: 1048 IQIQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYL 869
+QI GK V+TGAN+GIG A LA RGA VY+ CR+ +GE A S+I+ T N V +
Sbjct: 35 VQIPGKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIRADTKNSQVLV 94
Query: 868 EVCDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTM 689
DLS I++FA F +++ +H+L+NNAG++ + T +GFE +F +N LG + +
Sbjct: 95 RKLDLSDTKSIRAFAERFLAEEKKLHILINNAGVMMCPYSKTTDGFETHFGVNHLGHFLL 154
Query: 688 TELMLPLLEKASPDSKVITVSSGGMYTSPLT-TDLQFSGEKFDGVLQYARNKRIQVALTE 512
T L+L L++++P ++V+ +SS + DLQ +++ Y +K + T
Sbjct: 155 TYLLLERLKESAP-ARVVNLSSIAHLIGKIRFHDLQ-GQKRYCSAFAYGHSKLANLLFTR 212
Query: 511 KWADKYKNKGIGFYSMHPG--WAETPGVARSLPSFKESFSGKLRTSEEGADTVVWLALQP 338
+ A + + G+ Y++HPG +E + L FS +++ +GA T + AL
Sbjct: 213 ELAKRLQGTGVTAYAVHPGVVLSEITRNSYLLCLLWRLFSPFFKSTSQGAQTSLHCALAE 272
Query: 337 KEKLVSGAFYFD 302
+ +SG ++ D
Sbjct: 273 DLEPLSGKYFSD 284
>sp|Q8CEE7|RDH13_MOUSE Retinol dehydrogenase 13 OS=Mus musculus GN=Rdh13 PE=2
SV=1
Length = 334
Score = 128 bits (320), Expect = 1e-028
Identities = 78/217 (35%), Positives = 117/217 (53%), Gaps = 3/217 (1%)
Frame = -3
Query: 1042 IQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYLEV 863
I GK +VTGAN+GIG A LA RG NV + CR+ E+ E A I+ T N V E
Sbjct: 36 IPGKTVIVTGANTGIGKQTALELAKRGGNVILACRDMEKCEVAAKDIRGETLNPRVRAER 95
Query: 862 CDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTMTE 683
DL+S+ I+ FA ++ V +LVNNA ++ TT +GFE+ F +N LG + +T
Sbjct: 96 LDLASLKSIREFARKVIKEEERVDILVNNAAVMRCPHWTTEDGFEMQFGVNYLGHFLLTN 155
Query: 682 LMLPLLEKASPDSKVITVSSGGMYTSPLT-TDLQFSGEKFDGVLQYARNKRIQVALTEKW 506
L+L L KAS S++I +SS + DL + +K+D Y ++K V T++
Sbjct: 156 LLLDKL-KASAPSRIINLSSLAHVAGHIDFEDLNWQMKKYDTKAAYCQSKLAVVLFTKEL 214
Query: 505 ADKYKNKGIGFYSMHPGWAETPGVARSLPSFKESFSG 395
+ + + G+ ++HPG A T + R +FSG
Sbjct: 215 SHRLQGSGVTVNALHPGVARTE-LGRHTGMHNSAFSG 250
>sp|Q17QU7|DHR13_BOVIN Dehydrogenase/reductase SDR family member 13 OS=Bos
taurus GN=DHRS13 PE=2 SV=1
Length = 377
Score = 125 bits (312), Expect = 1e-027
Identities = 83/252 (32%), Positives = 131/252 (51%), Gaps = 10/252 (3%)
Frame = -3
Query: 1042 IQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYLEV 863
++G+ VVTGANSGIG A LA RGA V + CR++ERGE A ++ +GN V
Sbjct: 34 LRGRTAVVTGANSGIGKMTALELARRGARVVLACRSRERGEAAAFDLRQESGNNEVIFMA 93
Query: 862 CDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTMTE 683
DL+S+ +++FA+ F S + + +L++NAG+ RT P F L +N +G + +T
Sbjct: 94 LDLASLASVRAFATAFLSSEPRLDILIHNAGISSCGRTREP--FNLLLRVNHIGPFLLTH 151
Query: 682 LMLPLLEKASPDSKVITVSSGGMYTSPLT-TDLQFSGEKFDGVLQ-YARNKRIQVALTEK 509
L+LP L+ ++P S+V+ VSS L T L + L+ YA +K V +
Sbjct: 152 LLLPRLKTSAP-SRVVVVSSAAHRRGRLDFTRLDHPVVGWQQELRAYANSKLANVLFARE 210
Query: 508 WADKYKNKGIGFYSMHPGWAETPGVARSLPSFKESFSGK-----LRTSEEGADTVVWLAL 344
A + + G+ Y+ HPG + R +P + LR GA T ++ AL
Sbjct: 211 LATQLEGTGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCAL 270
Query: 343 QPKEKLVSGAFY 308
Q + +SG ++
Sbjct: 271 QEGIEPLSGRYF 282
>sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1
SV=2
Length = 331
Score = 124 bits (311), Expect = 1e-027
Identities = 71/201 (35%), Positives = 112/201 (55%), Gaps = 2/201 (0%)
Frame = -3
Query: 1042 IQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYLEV 863
I GK +VTGAN+GIG A LA RG N+ + CR+ E+ E A I+ T N +V
Sbjct: 36 IPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARH 95
Query: 862 CDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTMTE 683
DL+S+ I+ FA+ ++ V +L+NNAG++ TT +GFE+ F +N LG + +T
Sbjct: 96 LDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTN 155
Query: 682 LMLPLLEKASPDSKVITVSSGGMYTSPLT-TDLQFSGEKFDGVLQYARNKRIQVALTEKW 506
L+L L KAS S++I +SS + DL + K++ Y ++K V T++
Sbjct: 156 LLLDKL-KASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKEL 214
Query: 505 ADKYKNKGIGFYSMHPGWAET 443
+ + + G+ ++HPG A T
Sbjct: 215 SRRLQGSGVTVNALHPGVART 235
>sp|Q5SS80|DHR13_MOUSE Dehydrogenase/reductase SDR family member 13 OS=Mus
musculus GN=Dhrs13 PE=1 SV=1
Length = 376
Score = 123 bits (307), Expect = 4e-027
Identities = 84/253 (33%), Positives = 130/253 (51%), Gaps = 12/253 (4%)
Frame = -3
Query: 1042 IQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYLEV 863
++G+ VVTGANSGIG A LA RGA V + CR++ERGE A ++ +GN V
Sbjct: 34 LRGRTVVVTGANSGIGKMTALELARRGARVVLACRSRERGEAAAFDLRQESGNNEVIFMA 93
Query: 862 CDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTMTE 683
DL+S+ +++FA+ F S + + VL++NAG+ RT E F L +N +G + +T
Sbjct: 94 LDLASLASVQAFATAFLSSEPRLDVLIHNAGISSCGRTR--ETFNLLLRVNHVGPFLLTH 151
Query: 682 LMLPLLEKASPDSKVITVSSGGMYTSPL---TTDLQFSGEKFDGVLQYARNKRIQVALTE 512
L+LP L +P S+V+ VSS L D G + + + YA +K V
Sbjct: 152 LLLPRLRSCAP-SRVVIVSSAAHRRGRLDFTRLDCPVVGWQQE-LRAYADSKLANVLFAR 209
Query: 511 KWADKYKNKGIGFYSMHPGWAETPGVARSLPSFKESFSGK-----LRTSEEGADTVVWLA 347
+ A + + G+ Y+ HPG + R LP + LR + GA T ++ A
Sbjct: 210 ELATQLEGTGVTCYAAHPGPVNSELFLRHLPGWLRPILRPLAWLVLRAPQGGAQTPLYCA 269
Query: 346 LQPKEKLVSGAFY 308
LQ + +SG ++
Sbjct: 270 LQEGIEPLSGRYF 282
>sp|Q9ERI6|RDH14_MOUSE Retinol dehydrogenase 14 OS=Mus musculus GN=Rdh14 PE=1
SV=1
Length = 334
Score = 122 bits (306), Expect = 5e-027
Identities = 87/293 (29%), Positives = 146/293 (49%), Gaps = 26/293 (8%)
Frame = -3
Query: 1042 IQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQ-----------N 896
+ GK ++TGANSG+G A A L GA V M CR++ R EEA +++ +
Sbjct: 42 MHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRQELCQAGGAGPD 101
Query: 895 STGNQNVYLEVCDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFA 716
T Q V E+ DL+S+ +++F ++ + VL+NNAG+ T T +GFE+ F
Sbjct: 102 GTDGQLVVKEL-DLASLRSVRAFCQELLQEEPRLDVLINNAGVFHCPYTKTEDGFEMQFG 160
Query: 715 INVLGTYTMTELMLPLLEKASPDSKVITVSSGGMYTSPLTTDLQFSGEKFDGVLQYARNK 536
+N LG + +T L+L LL+ ++P S+++ VSS + + S + ++ Y+R+K
Sbjct: 161 VNHLGHFLLTNLLLGLLKSSAP-SRIVVVSSKLYKYGEINFEDLNSEQSYNKSFCYSRSK 219
Query: 535 RIQVALTEKWADKYKNKGIGFYSMHPGWAET--------PGVARSLPSFKESFSGKLRTS 380
+ T + A + + + +HPG T P +AR P F +T
Sbjct: 220 LANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLAR--PLFNLVSWAFFKTP 277
Query: 379 EEGADTVVWLALQPKEKLVSGAFYFDRAE---APKHLTLAGTSKSHDLIDAVI 230
EGA T ++LA P + VSG ++ D E PK + + K D+ + ++
Sbjct: 278 LEGAQTSIYLACSPDVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMV 330
>sp|Q6UX07|DHR13_HUMAN Dehydrogenase/reductase SDR family member 13 OS=Homo
sapiens GN=DHRS13 PE=1 SV=1
Length = 377
Score = 121 bits (303), Expect = 1e-026
Identities = 81/253 (32%), Positives = 130/253 (51%), Gaps = 12/253 (4%)
Frame = -3
Query: 1042 IQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYLEV 863
++G+ VVTGANSGIG A LA RGA V + CR++ERGE A ++ +GN V
Sbjct: 34 LRGRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMA 93
Query: 862 CDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTMTE 683
DL+S+ +++FA+ F S + + +L++NAG+ RT E F L +N +G + +T
Sbjct: 94 LDLASLASVRAFATAFLSSEPRLDILIHNAGISSCGRTR--EAFNLLLRVNHIGPFLLTH 151
Query: 682 LMLPLLEKASPDSKVITVSSGGMYTSPL---TTDLQFSGEKFDGVLQYARNKRIQVALTE 512
L+LP L+ +P S+V+ V+S L D G + + + YA K V
Sbjct: 152 LLLPCLKACAP-SRVVVVASAAHCRGRLDFKRLDRPVVGWRQE-LRAYADTKLANVLFAR 209
Query: 511 KWADKYKNKGIGFYSMHPGWAETPGVARSLPSFKESFSGK-----LRTSEEGADTVVWLA 347
+ A++ + G+ Y+ HPG + R +P + LR GA T ++ A
Sbjct: 210 ELANQLEATGVTCYAAHPGPVNSELFLRHVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCA 269
Query: 346 LQPKEKLVSGAFY 308
LQ + +SG ++
Sbjct: 270 LQEGIEPLSGRYF 282
>sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gallus gallus
GN=WWOX PE=2 SV=2
Length = 414
Score = 114 bits (285), Expect = 1e-024
Identities = 70/255 (27%), Positives = 127/255 (49%), Gaps = 10/255 (3%)
Frame = -3
Query: 1042 IQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYLEV 863
+ GK ++TGANSGIG+ A+ A GA V + CRN RG +A+ +I V
Sbjct: 122 LSGKVIIITGANSGIGFETAKSFALHGAYVILACRNMSRGNDAVQRILEEWHKAKVEAMT 181
Query: 862 CDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTMTE 683
DL+S+ +++FA F SK++P+H+LV NA + + T +G E F +N LG + + +
Sbjct: 182 LDLASLRSVQNFAEAFKSKNMPLHILVCNAAIFGSSWCLTEDGLESTFQVNHLGHFYLVQ 241
Query: 682 LMLPLLEKASPDSKVITVSSGGMYTSPLTTD-------LQFSGEKFDGVLQYARNKRIQV 524
L+ +L ++SP V+ S +T + L S +++ +L Y R+K +
Sbjct: 242 LLEDILRRSSPARVVVVSSESHRFTEIKDSSGKLDFSLLSPSKKEYWAMLAYNRSKLCNI 301
Query: 523 ALTEKWADKYKNKGIGFYSMHPGWAETPGVARSLPSFKESFS---GKLRTSEEGADTVVW 353
+ + + G+ S+HPG + R+ + F+ ++ ++GA T V+
Sbjct: 302 LFSNELNRRLSPHGVTSNSVHPGNMIYSSIHRNWWVYTLLFTLARPFTKSMQQGAATTVY 361
Query: 352 LALQPKEKLVSGAFY 308
A + + + G ++
Sbjct: 362 CATAAELEGLGGMYF 376
>sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pongo abelii
GN=WWOX PE=2 SV=1
Length = 414
Score = 114 bits (283), Expect = 2e-024
Identities = 80/258 (31%), Positives = 129/258 (50%), Gaps = 20/258 (7%)
Frame = -3
Query: 1036 GKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYLEVCD 857
GK VVTGANSGIG+ A+ A GA+V + CRN R EA+S+I V D
Sbjct: 124 GKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAVTLD 183
Query: 856 LSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTMTELM 677
L+ + ++ FA F +K+VP+HVLV NA + T +G E F +N LG + + +L+
Sbjct: 184 LALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLL 243
Query: 676 LPLLEKASPDSKVITVSSGGMYTSPLTTDLQFSGEKFD------------GVLQYARNKR 533
+L +++P ++VI VSS S TD+ S K D +L Y R+K
Sbjct: 244 QDVLCRSAP-ARVIVVSS----ESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKL 298
Query: 532 IQVALTEKWADKYKNKGIGFYSMHPGWAETPGVARSLPSFKESFS---GKLRTSEEGADT 362
V + + + +G+ ++HPG + RS + F+ ++ ++GA T
Sbjct: 299 CNVLFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAAT 358
Query: 361 VVWLALQPKEKLVSGAFY 308
V+ A P+ + + G ++
Sbjct: 359 TVYCAAAPELEGLGGMYF 376
>sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo sapiens
GN=WWOX PE=1 SV=1
Length = 414
Score = 113 bits (281), Expect = 4e-024
Identities = 79/258 (30%), Positives = 129/258 (50%), Gaps = 20/258 (7%)
Frame = -3
Query: 1036 GKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYLEVCD 857
GK VVTGANSGIG+ A+ A GA+V + CRN R EA+S+I V D
Sbjct: 124 GKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLD 183
Query: 856 LSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTMTELM 677
L+ + ++ FA F +K+VP+HVLV NA + T +G E F +N LG + + +L+
Sbjct: 184 LALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLL 243
Query: 676 LPLLEKASPDSKVITVSSGGMYTSPLTTDLQFSGEKFD------------GVLQYARNKR 533
+L +++P ++VI VSS S TD+ S K D +L Y R+K
Sbjct: 244 QDVLCRSAP-ARVIVVSS----ESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKL 298
Query: 532 IQVALTEKWADKYKNKGIGFYSMHPGWAETPGVARSLPSFKESFS---GKLRTSEEGADT 362
+ + + + +G+ ++HPG + RS + F+ ++ ++GA T
Sbjct: 299 CNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAAT 358
Query: 361 VVWLALQPKEKLVSGAFY 308
V+ A P+ + + G ++
Sbjct: 359 TVYCAAVPELEGLGGMYF 376
>sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member on chromosome X
OS=Homo sapiens GN=DHRSX PE=2 SV=2
Length = 330
Score = 112 bits (279), Expect = 7e-024
Identities = 64/173 (36%), Positives = 96/173 (55%), Gaps = 3/173 (1%)
Frame = -3
Query: 1024 VVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYLEVCDLSSV 845
+VTG GIGY+ A+ LA G +V + N + ++ +SKI+ T N V CDL+S+
Sbjct: 47 IVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLASM 106
Query: 844 NDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTMTELMLPLL 665
I+ F F K +P+HVL+NNAG++ + T +GFE +F +N LG + +T L+L L
Sbjct: 107 TSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLLDTL 166
Query: 664 -EKASP--DSKVITVSSGGMYTSPLTTDLQFSGEKFDGVLQYARNKRIQVALT 515
E SP ++V+TVSS Y + L D S + YA++K V T
Sbjct: 167 KESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFT 219
>sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Danio rerio GN=wwox
PE=2 SV=1
Length = 412
Score = 110 bits (274), Expect = 2e-023
Identities = 81/292 (27%), Positives = 134/292 (45%), Gaps = 34/292 (11%)
Frame = -3
Query: 1090 FLDHSKKFKPEDMQIQ------------------IQGKNCVVTGANSGIGYAAAEGLASR 965
+ D + F EDMQ++ + K +VTGANSGIG+ A A
Sbjct: 85 YFDPRQAFTVEDMQVKPKRYDGNTGALEILHGQDLSDKVIIVTGANSGIGFETARSFALH 144
Query: 964 GANVYMVCRNKERGEEALSKIQNSTGNQNVYLEVCDLSSVNDIKSFASTFASKDVPVHVL 785
GA+V + CRN+ R +A S I V + DL+S+ ++ FA F + +P+HVL
Sbjct: 145 GAHVILACRNQSRASKAASLIMGEWSKARVEVLPLDLASLRSVRQFAELFKATKLPLHVL 204
Query: 784 VNNAGLLENKRTTTPEGFELNFAINVLGTYTMTELMLPLLEKASPDSKVITVSSGGMYTS 605
V NA + T +GFE F I LG + + +L+ +L ++P V+ S +T
Sbjct: 205 VCNAAVCSQPWRLTEDGFESTFQICHLGHFLLVQLLQDVLRLSAPARVVVVSSESHRFTD 264
Query: 604 PLTT------DLQFSGEK-FDGVLQYARNKRIQVALTEKWADKYKNKGIGFYSMHPGWAE 446
L + DL +K + +L Y R K + + + + GI ++HPG
Sbjct: 265 LLDSCGNLDLDLLSPPQKNYWSLLAYNRAKLCNLLFSSELHRRMSPHGICCNALHPGSMM 324
Query: 445 TPGVARS------LPSFKESFSGKLRTSEEGADTVVWLALQPKEKLVSGAFY 308
+ RS L S F+ ++ ++GA T V+ A+ P+ + + G ++
Sbjct: 325 FTSIHRSWWLLTLLFSLARPFT---KSMQQGAATTVYCAVAPELEGIGGMYF 373
>sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus musculus
GN=Wwox PE=1 SV=1
Length = 414
Score = 107 bits (265), Expect = 3e-022
Identities = 69/206 (33%), Positives = 105/206 (50%), Gaps = 17/206 (8%)
Frame = -3
Query: 1036 GKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNSTGNQNVYLEVCD 857
GK +VTGANSGIG+ A+ A GA+V + CRN R EA+S+I V D
Sbjct: 124 GKVVLVTGANSGIGFETAKSFALHGAHVILACRNLSRASEAVSRILEEWHKAKVEAMTLD 183
Query: 856 LSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAINVLGTYTMTELM 677
L+ + ++ FA F +K+V +HVLV NAG T +G E F +N LG + + +L+
Sbjct: 184 LAVLRSVQHFAEAFKAKNVSLHVLVCNAGTFALPWGLTKDGLETTFQVNHLGHFYLVQLL 243
Query: 676 LPLLEKASPDSKVITVSSGGMYTSPLTTDLQFSGEKFD------------GVLQYARNKR 533
+L ++SP ++VI VSS S TD+ S K D +L Y R+K
Sbjct: 244 QDVLCRSSP-ARVIVVSS----ESHRFTDINDSSGKLDLSRLSPPRSDYWAMLAYNRSKL 298
Query: 532 IQVALTEKWADKYKNKGIGFYSMHPG 455
+ + + + +G+ ++HPG
Sbjct: 299 CNILFSNELHRRLSPRGVTSNAVHPG 324
>sp|Q8VBZ0|DHRSX_MOUSE Dehydrogenase/reductase SDR family member on chromosome X
homolog OS=Mus musculus GN=Dhrsx PE=2 SV=2
Length = 335
Score = 100 bits (247), Expect = 3e-020
Identities = 58/181 (32%), Positives = 96/181 (53%), Gaps = 4/181 (2%)
Frame = -3
Query: 1069 FKPEDMQIQIQGKNCVVTGANSGIGYAAAEGLASRGANVYMVCRNKERGEEALSKIQNST 890
F+P + Q G+ +VTGA +GIG + A LA G V + ++ RG+E +S I+
Sbjct: 33 FRPPVLPPQ-PGRVAIVTGATAGIGRSTARQLARLGMCVVVAGNDEHRGQEVVSSIRAEM 91
Query: 889 GNQNVYLEVCDLSSVNDIKSFASTFASKDVPVHVLVNNAGLLENKRTTTPEGFELNFAIN 710
G+ + DL+S+ ++ FA F + +P+H+LVNNAG++ R T +GFE + +N
Sbjct: 92 GSDRAHFLPLDLASLASVRGFARDFQALGLPLHLLVNNAGVMLEPRAETEDGFERHLGVN 151
Query: 709 VLGTYTMTELMLPLLEKASPD---SKVITVSSGGMYTSPLTTDLQFSGEKFDGVLQYARN 539
LG + +T L+LP L + + S+V+TV S Y + + YA++
Sbjct: 152 FLGHFLLTLLLLPALRASGAEGRGSRVVTVGSATHYVGTVDMADLHGRHAYSPYAAYAQS 211
Query: 538 K 536
K
Sbjct: 212 K 212
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,872,592,117
Number of Sequences: 518415
Number of Extensions: 81872592117
Number of Successful Extensions: 541474699
Number of sequences better than 0.0: 0
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