BLASTX 7.6.2
Query= UN20038 /QuerySize=1680
(1679 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8W207|CSN2_ARATH COP9 signalosome complex subunit 2 OS=Arabi... 842 2e-243
sp|Q6IR75|CSN2_XENLA COP9 signalosome complex subunit 2 (Fragmen... 557 1e-157
sp|P61201|CSN2_HUMAN COP9 signalosome complex subunit 2 OS=Homo ... 553 2e-156
sp|P61202|CSN2_MOUSE COP9 signalosome complex subunit 2 OS=Mus m... 553 2e-156
sp|P61203|CSN2_RAT COP9 signalosome complex subunit 2 OS=Rattus ... 553 2e-156
sp|Q6IQT4|CSN2_DANRE COP9 signalosome complex subunit 2 OS=Danio... 553 2e-156
sp|Q54HL6|CSN2_DICDI COP9 signalosome complex subunit 2 OS=Dicty... 530 1e-149
sp|Q94899|CSN2_DROME COP9 signalosome complex subunit 2 OS=Droso... 530 1e-149
sp|O01422|CSN2_CAEEL COP9 signalosome complex subunit 2 OS=Caeno... 465 6e-130
sp|Q5B3U7|CSN2_EMENI COP9 signalosome complex subunit 2 OS=Emeri... 453 3e-126
sp|Q7SI58|CSN2_NEUCR COP9 signalosome complex subunit 2 OS=Neuro... 438 8e-122
sp|Q9HFR0|CSN2_SCHPO COP9 signalosome complex subunit 2 OS=Schiz... 397 1e-109
>sp|Q8W207|CSN2_ARATH COP9 signalosome complex subunit 2 OS=Arabidopsis thaliana
GN=CSN2 PE=1 SV=1
Length = 439
Score = 842 bits (2174), Expect = 2e-243
Identities = 417/439 (94%), Positives = 430/439 (97%)
Frame = +3
Query: 180 MASDADMEDYGFEYSDDEQEEQDVDIENQYYSAKGMVETEPEAALSEFAEVVKMEPDKAE 359
MASDADMEDYGFEYSD+EQEEQDVDIENQYY++KGMVETEPE ALS FAEVV+MEP+KA+
Sbjct: 1 MASDADMEDYGFEYSDEEQEEQDVDIENQYYNSKGMVETEPEEALSGFAEVVQMEPEKAD 60
Query: 360 WGFKALKQTVKIYYRLGKYKEMMDAYREMLTYIKSAVTRNYSEKCINNIMDFVSGSASQN 539
WGFKALKQTVKIYYRLGKYKEMM+AY EMLTYIKSAVTRNYSEKCINNIMDFVSGSASQN
Sbjct: 61 WGFKALKQTVKIYYRLGKYKEMMEAYTEMLTYIKSAVTRNYSEKCINNIMDFVSGSASQN 120
Query: 540 TGLLQEFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDG 719
TGLLQEFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDG
Sbjct: 121 TGLLQEFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDG 180
Query: 720 TDDQKKGSQLLEVYAIEIQIYTETKDNKKLKQLYQKALAIKSAIPHPRIMGIIRECGGKM 899
TDDQKKGSQLLEVYAIEIQIYTETKDNKKLKQLY KALAIKSAIPHPRIMGIIRECGGKM
Sbjct: 181 TDDQKKGSQLLEVYAIEIQIYTETKDNKKLKQLYHKALAIKSAIPHPRIMGIIRECGGKM 240
Query: 900 HMAERQWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKN 1079
HMAERQW EAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKN
Sbjct: 241 HMAERQWEEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKN 300
Query: 1080 DPEILAMTNLIAAYQRNEIIEFEKILKNNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIK 1259
DPEILAMTNLIAAYQRNEIIEFE+ILK+NRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIK
Sbjct: 301 DPEILAMTNLIAAYQRNEIIEFERILKSNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIK 360
Query: 1260 PYTKIKIPFISKELNVPEKDVTELLVSLILDSRIDGHIDEINRYLLRGDSANGRKLHKAV 1439
PYTKI IPFISKELNVPE DVTELLVSLILDSRIDGHIDE+NRYLLRGDS NGRKLHKAV
Sbjct: 361 PYTKIGIPFISKELNVPETDVTELLVSLILDSRIDGHIDEMNRYLLRGDSGNGRKLHKAV 420
Query: 1440 DKWNTQLKSLSMSITNRVC 1496
DKWN+QLKSLS +IT+RVC
Sbjct: 421 DKWNSQLKSLSSNITSRVC 439
>sp|Q6IR75|CSN2_XENLA COP9 signalosome complex subunit 2 (Fragment) OS=Xenopus
laevis GN=csn2 PE=2 SV=1
Length = 441
Score = 557 bits (1434), Expect = 1e-157
Identities = 266/433 (61%), Positives = 345/433 (79%), Gaps = 2/433 (0%)
Frame = +3
Query: 195 DMEDYGFEYSDDEQEEQDVDIENQYYSAKGMVETEPEAALSEFAEVVKMEPDKAEWGFKA 374
D EDY EYS+D E +VD+ENQYY++K + E +P+AALS F +V+++E +K EWGFKA
Sbjct: 10 DEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKA 69
Query: 375 LKQTVKIYYRLGKYKEMMDAYREMLTYIKSAVTRNYSEKCINNIMDFVSGSASQNTGLLQ 554
LKQ +KI ++LG Y EMM+ Y+++LTYI+SAVTRNYSEK IN+I+D++ S S+ LLQ
Sbjct: 70 LKQMIKINFKLGNYPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYI--STSKQMDLLQ 127
Query: 555 EFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDGTDDQK 734
EFY+TTL AL++AKN+RLWFKTN KL ++ + EY ++ KIL++LH+SCQ +DG DD K
Sbjct: 128 EFYETTLDALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLK 187
Query: 735 KGSQLLEVYAIEIQIYTETKDNKKLKQLYQKALAIKSAIPHPRIMGIIRECGGKMHMAER 914
KG+QLLE+YA+EIQ+YT K+NKKLK LY+++L IKSAIPHP IMG+IRECGGKMH+ E
Sbjct: 188 KGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREG 247
Query: 915 QWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKNDPEIL 1094
++ +A TDFFEAFKNYDE+G+ RR CLKYLVLANMLM+S +NPFD QEAKPYKNDPEIL
Sbjct: 248 EFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEIL 307
Query: 1095 AMTNLIAAYQRNEIIEFEKILKNNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIKPYTKI 1274
AMTNL++AYQ N+I EFEKILK N IMDDPFIR ++E+LL+ +RTQVL+KLIKPYT+I
Sbjct: 308 AMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRI 367
Query: 1275 KIPFISKELNVPEKDVTELLVSLILDSRIDGHIDEINRYLLRGDSANGRKLHKAVDKWNT 1454
IPFISKELN+ DV LLV ILD+ I G ID++N+ L G + A+DKW
Sbjct: 368 HIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTN 427
Query: 1455 QLKSLSMSITNRV 1493
QL SL+ ++ +++
Sbjct: 428 QLNSLNQAVVSKL 440
>sp|P61201|CSN2_HUMAN COP9 signalosome complex subunit 2 OS=Homo sapiens
GN=COPS2 PE=1 SV=1
Length = 443
Score = 553 bits (1424), Expect = 2e-156
Identities = 264/433 (60%), Positives = 345/433 (79%), Gaps = 2/433 (0%)
Frame = +3
Query: 195 DMEDYGFEYSDDEQEEQDVDIENQYYSAKGMVETEPEAALSEFAEVVKMEPDKAEWGFKA 374
D EDY EYS+D E +VD+ENQYY++K + E +P+AALS F +V+++E +K EWGFKA
Sbjct: 12 DEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKA 71
Query: 375 LKQTVKIYYRLGKYKEMMDAYREMLTYIKSAVTRNYSEKCINNIMDFVSGSASQNTGLLQ 554
LKQ +KI ++L + EMM+ Y+++LTYI+SAVTRNYSEK IN+I+D++ S S+ LLQ
Sbjct: 72 LKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYI--STSKQMDLLQ 129
Query: 555 EFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDGTDDQK 734
EFY+TTL+AL++AKN+RLWFKTN KL ++ + EY ++ KIL++LH+SCQ +DG DD K
Sbjct: 130 EFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLK 189
Query: 735 KGSQLLEVYAIEIQIYTETKDNKKLKQLYQKALAIKSAIPHPRIMGIIRECGGKMHMAER 914
KG+QLLE+YA+EIQ+YT K+NKKLK LY+++L IKSAIPHP IMG+IRECGGKMH+ E
Sbjct: 190 KGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREG 249
Query: 915 QWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKNDPEIL 1094
++ +A TDFFEAFKNYDE+G+ RR CLKYLVLANMLM+S +NPFD QEAKPYKNDPEIL
Sbjct: 250 EFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEIL 309
Query: 1095 AMTNLIAAYQRNEIIEFEKILKNNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIKPYTKI 1274
AMTNL++AYQ N+I EFEKILK N IMDDPFIR ++E+LL+ +RTQVL+KLIKPYT+I
Sbjct: 310 AMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRI 369
Query: 1275 KIPFISKELNVPEKDVTELLVSLILDSRIDGHIDEINRYLLRGDSANGRKLHKAVDKWNT 1454
IPFISKELN+ DV LLV ILD+ I G ID++N+ L G + A+DKW
Sbjct: 370 HIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTN 429
Query: 1455 QLKSLSMSITNRV 1493
QL SL+ ++ +++
Sbjct: 430 QLNSLNQAVVSKL 442
>sp|P61202|CSN2_MOUSE COP9 signalosome complex subunit 2 OS=Mus musculus
GN=Cops2 PE=1 SV=1
Length = 443
Score = 553 bits (1424), Expect = 2e-156
Identities = 264/433 (60%), Positives = 345/433 (79%), Gaps = 2/433 (0%)
Frame = +3
Query: 195 DMEDYGFEYSDDEQEEQDVDIENQYYSAKGMVETEPEAALSEFAEVVKMEPDKAEWGFKA 374
D EDY EYS+D E +VD+ENQYY++K + E +P+AALS F +V+++E +K EWGFKA
Sbjct: 12 DEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKA 71
Query: 375 LKQTVKIYYRLGKYKEMMDAYREMLTYIKSAVTRNYSEKCINNIMDFVSGSASQNTGLLQ 554
LKQ +KI ++L + EMM+ Y+++LTYI+SAVTRNYSEK IN+I+D++ S S+ LLQ
Sbjct: 72 LKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYI--STSKQMDLLQ 129
Query: 555 EFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDGTDDQK 734
EFY+TTL+AL++AKN+RLWFKTN KL ++ + EY ++ KIL++LH+SCQ +DG DD K
Sbjct: 130 EFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLK 189
Query: 735 KGSQLLEVYAIEIQIYTETKDNKKLKQLYQKALAIKSAIPHPRIMGIIRECGGKMHMAER 914
KG+QLLE+YA+EIQ+YT K+NKKLK LY+++L IKSAIPHP IMG+IRECGGKMH+ E
Sbjct: 190 KGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREG 249
Query: 915 QWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKNDPEIL 1094
++ +A TDFFEAFKNYDE+G+ RR CLKYLVLANMLM+S +NPFD QEAKPYKNDPEIL
Sbjct: 250 EFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEIL 309
Query: 1095 AMTNLIAAYQRNEIIEFEKILKNNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIKPYTKI 1274
AMTNL++AYQ N+I EFEKILK N IMDDPFIR ++E+LL+ +RTQVL+KLIKPYT+I
Sbjct: 310 AMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRI 369
Query: 1275 KIPFISKELNVPEKDVTELLVSLILDSRIDGHIDEINRYLLRGDSANGRKLHKAVDKWNT 1454
IPFISKELN+ DV LLV ILD+ I G ID++N+ L G + A+DKW
Sbjct: 370 HIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTN 429
Query: 1455 QLKSLSMSITNRV 1493
QL SL+ ++ +++
Sbjct: 430 QLNSLNQAVVSKL 442
>sp|P61203|CSN2_RAT COP9 signalosome complex subunit 2 OS=Rattus norvegicus
GN=Cops2 PE=2 SV=1
Length = 443
Score = 553 bits (1424), Expect = 2e-156
Identities = 264/433 (60%), Positives = 345/433 (79%), Gaps = 2/433 (0%)
Frame = +3
Query: 195 DMEDYGFEYSDDEQEEQDVDIENQYYSAKGMVETEPEAALSEFAEVVKMEPDKAEWGFKA 374
D EDY EYS+D E +VD+ENQYY++K + E +P+AALS F +V+++E +K EWGFKA
Sbjct: 12 DEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKA 71
Query: 375 LKQTVKIYYRLGKYKEMMDAYREMLTYIKSAVTRNYSEKCINNIMDFVSGSASQNTGLLQ 554
LKQ +KI ++L + EMM+ Y+++LTYI+SAVTRNYSEK IN+I+D++ S S+ LLQ
Sbjct: 72 LKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYI--STSKQMDLLQ 129
Query: 555 EFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDGTDDQK 734
EFY+TTL+AL++AKN+RLWFKTN KL ++ + EY ++ KIL++LH+SCQ +DG DD K
Sbjct: 130 EFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLK 189
Query: 735 KGSQLLEVYAIEIQIYTETKDNKKLKQLYQKALAIKSAIPHPRIMGIIRECGGKMHMAER 914
KG+QLLE+YA+EIQ+YT K+NKKLK LY+++L IKSAIPHP IMG+IRECGGKMH+ E
Sbjct: 190 KGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREG 249
Query: 915 QWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKNDPEIL 1094
++ +A TDFFEAFKNYDE+G+ RR CLKYLVLANMLM+S +NPFD QEAKPYKNDPEIL
Sbjct: 250 EFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEIL 309
Query: 1095 AMTNLIAAYQRNEIIEFEKILKNNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIKPYTKI 1274
AMTNL++AYQ N+I EFEKILK N IMDDPFIR ++E+LL+ +RTQVL+KLIKPYT+I
Sbjct: 310 AMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRI 369
Query: 1275 KIPFISKELNVPEKDVTELLVSLILDSRIDGHIDEINRYLLRGDSANGRKLHKAVDKWNT 1454
IPFISKELN+ DV LLV ILD+ I G ID++N+ L G + A+DKW
Sbjct: 370 HIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTN 429
Query: 1455 QLKSLSMSITNRV 1493
QL SL+ ++ +++
Sbjct: 430 QLNSLNQAVVSKL 442
>sp|Q6IQT4|CSN2_DANRE COP9 signalosome complex subunit 2 OS=Danio rerio GN=cops2
PE=2 SV=1
Length = 443
Score = 553 bits (1423), Expect = 2e-156
Identities = 264/433 (60%), Positives = 346/433 (79%), Gaps = 2/433 (0%)
Frame = +3
Query: 195 DMEDYGFEYSDDEQEEQDVDIENQYYSAKGMVETEPEAALSEFAEVVKMEPDKAEWGFKA 374
D EDY EYS+D E +VD+ENQYY++K + E +P+AALS F +V+++E +K EWGFKA
Sbjct: 12 DEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKA 71
Query: 375 LKQTVKIYYRLGKYKEMMDAYREMLTYIKSAVTRNYSEKCINNIMDFVSGSASQNTGLLQ 554
LKQ +KI ++L + EMM+ Y+++LTYI+SAVTRNYSEK IN+I+D++ S S+ LLQ
Sbjct: 72 LKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYI--STSKQMDLLQ 129
Query: 555 EFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDGTDDQK 734
EFY+TTL+AL++AKN+RLWFKTN KL ++ + E+ ++ KIL++LH+SCQ +DG DD K
Sbjct: 130 EFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEFGKLQKILRQLHQSCQTDDGEDDLK 189
Query: 735 KGSQLLEVYAIEIQIYTETKDNKKLKQLYQKALAIKSAIPHPRIMGIIRECGGKMHMAER 914
KG+QLLE+YA+EIQ+YT K+NKKLK LY+++L IKSAIPHP IMG+IRECGGKMH+ E
Sbjct: 190 KGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREG 249
Query: 915 QWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKNDPEIL 1094
++ +A TDFFEAFKNYDE+G+ RR CLKYLVLANMLM+S +NPFD QEAKPYKNDPEIL
Sbjct: 250 EFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEIL 309
Query: 1095 AMTNLIAAYQRNEIIEFEKILKNNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIKPYTKI 1274
AMTNL++AYQ N+I EFEKILK N IMDDPFIR ++E+LL+ +RTQVL+KLIKPYT+I
Sbjct: 310 AMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRI 369
Query: 1275 KIPFISKELNVPEKDVTELLVSLILDSRIDGHIDEINRYLLRGDSANGRKLHKAVDKWNT 1454
IPFISKELN+ DV LLV ILD+ I+G ID++N+ L G + A+DKW
Sbjct: 370 HIPFISKELNIDVADVESLLVQCILDNTINGRIDQVNQLLELDHQKRGGARYTALDKWTN 429
Query: 1455 QLKSLSMSITNRV 1493
QL SL+ +I +++
Sbjct: 430 QLNSLNQAIVSKL 442
>sp|Q54HL6|CSN2_DICDI COP9 signalosome complex subunit 2 OS=Dictyostelium
discoideum GN=csn2 PE=1 SV=1
Length = 449
Score = 530 bits (1364), Expect = 1e-149
Identities = 255/441 (57%), Positives = 342/441 (77%), Gaps = 2/441 (0%)
Frame = +3
Query: 177 VMASDADMEDYGFEYSDDEQEEQDVDIENQYYSAKGMVETEPEAALSEFAEVVKME-PDK 353
+M D + D + ++ E + V+IENQYY++KG+++ A+ + +VV +E +K
Sbjct: 7 MMYDDDEYFDDDEDQDQNDSESEGVEIENQYYNSKGLIDESIPDAIKSYEKVVDLENGEK 66
Query: 354 AEWGFKALKQTVKIYYRLGKYKEMMDAYREMLTYIKSAVTRNYSEKCINNIMDFVSGSAS 533
EWGFKALK+ K+Y+R+G + M++++++ L Y KS+ + NY EK IN+++D VS S +
Sbjct: 67 GEWGFKALKKITKLYFRIGDFDNMLESFKKFLPYTKSSASSNYIEKGINSVLDMVSSSNT 126
Query: 534 QNTGLLQEFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKE 713
++Q+ + TLK+L + KNER+WF+TNLKL + F+ EY R+ KIL++LHKSC+ E
Sbjct: 127 IELDMIQKVFDLTLKSLLDTKNERVWFRTNLKLAKLLFEKAEYGRLAKILRDLHKSCELE 186
Query: 714 DGTDDQKKGSQLLEVYAIEIQIYTETKDNKKLKQLYQKALAIKSAIPHPRIMGIIRECGG 893
DGTDDQKKGSQL+++YA+EIQ+YTETK+NKKLK LY+KAL IKSAIPHPRIMGIIRECGG
Sbjct: 187 DGTDDQKKGSQLVDIYALEIQMYTETKNNKKLKDLYKKALEIKSAIPHPRIMGIIRECGG 246
Query: 894 KMHMAERQWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPY 1073
KMHMAE++W +A TDFFEAFKNYDEAGN RRIQCLKYLVLA MLM S +NPFD EAKPY
Sbjct: 247 KMHMAEKEWEKAHTDFFEAFKNYDEAGNSRRIQCLKYLVLACMLMLSTINPFDSTEAKPY 306
Query: 1074 KNDPEILAMTNLIAAYQRNEIIEFEKILKNNRRTIMDDPFIRNYMEDLLKKVRTQVLLKL 1253
KNDP+ILAMTNL+ AY++N+I FEKILK+NR+TIMDDPFIR Y+EDLL+ +RTQVLLKL
Sbjct: 307 KNDPDILAMTNLVMAYEKNDIYAFEKILKDNRKTIMDDPFIRMYIEDLLRNIRTQVLLKL 366
Query: 1254 IKPYTKIKIPFISKELNVPEKDVTELLVSLILDSRIDGHIDEINRYL-LRGDSANGRKLH 1430
+KPYT+I+I FISKELN+P DV LLVSLILD++I G ID++N+ L L ++ +
Sbjct: 367 LKPYTRIRISFISKELNIPSSDVESLLVSLILDNKIRGSIDQVNQQLELDTAKSSAYWKY 426
Query: 1431 KAVDKWNTQLKSLSMSITNRV 1493
++ KW Q+ L+ I N++
Sbjct: 427 TSIHKWANQIGQLNGGINNKL 447
>sp|Q94899|CSN2_DROME COP9 signalosome complex subunit 2 OS=Drosophila
melanogaster GN=alien PE=1 SV=2
Length = 444
Score = 530 bits (1364), Expect = 1e-149
Identities = 257/434 (59%), Positives = 336/434 (77%), Gaps = 3/434 (0%)
Frame = +3
Query: 195 DMEDYGFEYSDDEQEEQDVDIENQYYSAKGMVETEPEAALSEFAEVVKME-PDKAEWGFK 371
D EDYG EYS+D E DVD+ENQYY++K + E EP+AAL+ F +V+ +E +K EWGFK
Sbjct: 12 DDEDYGLEYSEDSNSEPDVDLENQYYNSKALKEEEPKAALASFQKVLDLENGEKGEWGFK 71
Query: 372 ALKQTVKIYYRLGKYKEMMDAYREMLTYIKSAVTRNYSEKCINNIMDFVSGSASQNTGLL 551
ALKQ +KI +RL Y EMM Y+++LTYIKSAVTRN+SEK IN+I+D++ S S+N LL
Sbjct: 72 ALKQMIKINFRLCNYDEMMVRYKQLLTYIKSAVTRNHSEKSINSILDYI--STSKNMALL 129
Query: 552 QEFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDGTDDQ 731
Q FY+TTL AL +AKN+RLWFKTN KL ++FD ++ ++ KILK+LH+SCQ +DG DD
Sbjct: 130 QNFYETTLDALRDAKNDRLWFKTNTKLGKLYFDRSDFTKLQKILKQLHQSCQTDDGEDDL 189
Query: 732 KKGSQLLEVYAIEIQIYTETKDNKKLKQLYQKALAIKSAIPHPRIMGIIRECGGKMHMAE 911
KKG+QLLE+YA+EIQ+YT K+NKKLK LY+++L IKSAIPHP IMG+IRECGGKMH+ E
Sbjct: 190 KKGTQLLEIYALEIQMYTVQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLRE 249
Query: 912 RQWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKNDPEI 1091
++ +A TDFFEAFKNYDE+G+ RR CLKYLVLANMLM+S +NPFD QEAKPYKNDPEI
Sbjct: 250 GEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEI 309
Query: 1092 LAMTNLIAAYQRNEIIEFEKILKNNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIKPYTK 1271
LAMTNL+ +YQ N+I EFE IL+ +R IM D FIR ++EDLL+ +RTQVL+KLI+PY
Sbjct: 310 LAMTNLVNSYQNNDINEFETILRQHRSNIMADQFIREHIEDLLRNIRTQVLIKLIRPYKN 369
Query: 1272 IKIPFISKELNVPEKDVTELLVSLILDSRIDGHIDEINRYLLRGDSANGRKLHKAVDKWN 1451
I IPFI+ LN+ +V LLVS ILD I G ID++N+ L + + A++KW+
Sbjct: 370 IAIPFIANALNIEPAEVESLLVSCILDDTIKGRIDQVNQVLQLDKINSSASRYNALEKWS 429
Query: 1452 TQLKSLSMSITNRV 1493
Q++SL ++ ++
Sbjct: 430 NQIQSLQFAVVQKM 443
>sp|O01422|CSN2_CAEEL COP9 signalosome complex subunit 2 OS=Caenorhabditis
elegans GN=csn-2 PE=1 SV=2
Length = 495
Score = 465 bits (1195), Expect = 6e-130
Identities = 223/399 (55%), Positives = 312/399 (78%), Gaps = 6/399 (1%)
Frame = +3
Query: 195 DMEDYGFEYSDDEQEEQDVDIENQYYSAKGM-VETEPEAALSEFAEVVKMEPDKAEWGFK 371
D EDYGFEY DD E DVD+ENQYY+AKG+ + + + A+ F +V+++E +K EWGFK
Sbjct: 8 DDEDYGFEYEDDSGSEPDVDMENQYYTAKGLRSDGKLDEAIKSFEKVLELEGEKGEWGFK 67
Query: 372 ALKQTVKIYYRLGKYKEMMDAYREMLTYIKSAVTRNYSEKCINNIMDFVSGSASQNTGLL 551
ALKQ +KI + + ++M++ YR++LTYIKSAVT+NYSEK IN I+D++ S S+ LL
Sbjct: 68 ALKQMIKITFGQNRLEKMLEYYRQLLTYIKSAVTKNYSEKSINAILDYI--STSRQMDLL 125
Query: 552 QEFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDGTDDQ 731
Q FY+TTL AL++AKNERLWFKTN KL ++FD+ E+ ++ KI+K+L SC+ E G +DQ
Sbjct: 126 QHFYETTLDALKDAKNERLWFKTNTKLGKLFFDLHEFTKLEKIVKQLKVSCKNEQGEEDQ 185
Query: 732 KKGSQLLEVYAIEIQIYTETKDNKKLKQLYQ---KALAIKSAIPHPRIMGIIRECGGKMH 902
+KG+QLLE+YA+EIQ+YTE K+NK LK +Y+ +A+ KSAIPHP I+G IRECGGKMH
Sbjct: 186 RKGTQLLEIYALEIQMYTEQKNNKALKWVYELATQAIHTKSAIPHPLILGTIRECGGKMH 245
Query: 903 MAERQWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKND 1082
+ + ++ +A TDFFEAFKNYDE+G+ RR CLKYLVLANML++S++NPFD QEAKP+KN+
Sbjct: 246 LRDGRFLDAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLIKSDINPFDSQEAKPFKNE 305
Query: 1083 PEILAMTNLIAAYQRNEIIEFEKILKNNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIKP 1262
PEI+AMT ++ AYQ N+I FE+I+ ++ +IM DPFIR + E+L+ +RTQVLL+LI+P
Sbjct: 306 PEIVAMTQMVQAYQDNDIQAFEQIMAAHQDSIMADPFIREHTEELMNNIRTQVLLRLIRP 365
Query: 1263 YTKIKIPFISKELNVPEKDVTELLVSLILDSRIDGHIDE 1379
YT ++I ++S++L V +K+V LLV ILD ++ I+E
Sbjct: 366 YTNVRISYLSQKLKVSQKEVIHLLVDAILDDGLEAKINE 404
>sp|Q5B3U7|CSN2_EMENI COP9 signalosome complex subunit 2 OS=Emericella nidulans
GN=csnB PE=1 SV=2
Length = 506
Score = 453 bits (1163), Expect = 3e-126
Identities = 210/430 (48%), Positives = 313/430 (72%), Gaps = 5/430 (1%)
Frame = +3
Query: 189 DADMEDYGFEYSD-DEQEEQDVDIENQYYSAKGMVETEPEAALSEFAEVVKMEPDKAEWG 365
D+ E+Y FEY D D+ E D+ IEN+YY+AK + PE A+ EF V +E DK +WG
Sbjct: 10 DSADEEYDFEYEDADDDETGDIGIENKYYNAKQIKVDNPEEAIDEFLGVPALEQDKGDWG 69
Query: 366 FKALKQTVKIYYRLGKYKEMMDAYREMLTYIKSAVTRNYSEKCINNIMDFVSGSASQNTG 545
FK LKQ +K+ ++LG+Y + ++ YRE+LTY+KSAVTRNYSEK INN++D++ +
Sbjct: 70 FKGLKQAIKLEFKLGRYSDAVEHYRELLTYVKSAVTRNYSEKSINNMLDYIEKGSDDEKA 129
Query: 546 --LLQEFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDG 719
++EFY TL + + NERLW KTN+KL +W + EY +++K ++ELH++CQ+EDG
Sbjct: 130 YQCMEEFYSLTLNSFQNTNNERLWLKTNIKLARLWLERREYGQLSKKVRELHRACQREDG 189
Query: 720 TDDQKKGSQLLEVYAIEIQIYTETKDNKKLKQLYQKALAIKSAIPHPRIMGIIRECGGKM 899
+DD KG+ LLE+YA+EIQ+Y ETK+NK+LK LYQ+AL ++SA+PHP+IMGIIRECGGKM
Sbjct: 190 SDDPSKGTYLLELYALEIQMYAETKNNKRLKALYQRALRVRSAVPHPKIMGIIRECGGKM 249
Query: 900 HMAERQWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKN 1079
HM+E W EA +DFFE+F+NYDEAG+ +RIQ LKYLVL MLM+S++NPF QE KPYK
Sbjct: 250 HMSEENWEEAQSDFFESFRNYDEAGSMQRIQVLKYLVLTTMLMKSDINPFHSQETKPYKT 309
Query: 1080 DPEILAMTNLIAAYQRNEIIEFEKILKNNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIK 1259
DP I AMT+L+ A+QR++I +E++L N ++ DPFI ++++ + +RT+ +LKLI
Sbjct: 310 DPRISAMTDLVDAFQRDDIHAYEEVLSKN-PDVLADPFIAENIDEVSRNMRTKAILKLIA 368
Query: 1260 PYTKIKIPFISKELNVPEKDVTELLVSLILDSRIDGHIDEINRYLLRGDSANGRKLHKAV 1439
PYT+ + FISK + + + ++L LILD +++ ID+ + ++ +++ +L ++V
Sbjct: 369 PYTRFTLSFISKHIKISVTEAQDILSFLILDKKLNAKIDQESGTVVVESASDVERL-RSV 427
Query: 1440 DKWNTQLKSL 1469
++WN L++L
Sbjct: 428 EEWNESLRTL 437
>sp|Q7SI58|CSN2_NEUCR COP9 signalosome complex subunit 2 OS=Neurospora crassa
GN=csn-2 PE=1 SV=1
Length = 490
Score = 438 bits (1125), Expect = 8e-122
Identities = 203/400 (50%), Positives = 295/400 (73%), Gaps = 5/400 (1%)
Frame = +3
Query: 189 DADMEDYGFEYSDDEQEEQ-DVDIENQYYSAKGMVETEPEAALSEFAEVVKMEPDKAEWG 365
D+D E Y FEY DDE+E+ DVDIEN+YY+AK ++PE AL EF + +E +K +WG
Sbjct: 9 DSDQE-YDFEYEDDEEEDTGDVDIENKYYNAKQTKTSDPEEALQEFLSIPPLEQEKGDWG 67
Query: 366 FKALKQTVKIYYRLGKYKEMMDAYREMLTYIKSAVTRNYSEKCINNIMDFVSGSASQNTG 545
FKALKQ +K+ ++L +Y+E + Y E+LTY+KSAVTRNYSEK I+N+++++
Sbjct: 68 FKALKQAIKLEFKLKRYQEATEHYEELLTYVKSAVTRNYSEKSIDNMLNYIEKGYDDPKA 127
Query: 546 L--LQEFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKEDG 719
+ +++FY TL+ + NERLW KTN+KL + D +Y + + L+ELH +C+K DG
Sbjct: 128 VQCIEKFYSLTLQCFQSTNNERLWLKTNIKLARLLLDRKDYHAVARKLRELHNACRKSDG 187
Query: 720 TDDQKKGSQLLEVYAIEIQIYTETKDNKKLKQLYQKALAIKSAIPHPRIMGIIRECGGKM 899
TDD KG+ LE+YA+EIQ+Y+ET++N +LK LYQKAL ++SA+PHP+I G+IRECGGKM
Sbjct: 188 TDDPSKGTYSLEIYALEIQMYSETRNNNQLKVLYQKALKVRSAVPHPKIQGVIRECGGKM 247
Query: 900 HMAERQWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKN 1079
HM+E W EA +DFFEAF+NYDEAG+ RRIQ LKYL+L MLM+S++NPFD QE KPY+N
Sbjct: 248 HMSEENWKEAQSDFFEAFRNYDEAGDLRRIQVLKYLLLTTMLMKSDINPFDSQEMKPYRN 307
Query: 1080 DPEILAMTNLIAAYQRNEIIEFEKILKNNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIK 1259
DP I AMT L+ AYQR++I +E +L+ N ++ DPFI ++++ + +RT+ ++KLI
Sbjct: 308 DPRIFAMTELVDAYQRDDIYRYEDVLQKN-TDLLADPFIAENIDEVTRNMRTKGVVKLIA 366
Query: 1260 PYTKIKIPFISKELNVPEKDVTELLVSLILDSRIDGHIDE 1379
PYT+++I ++++ L + E +V ++L LI+D R+ G IDE
Sbjct: 367 PYTRMRISWLAERLRITEPEVMDILSFLIVDGRVKGRIDE 406
>sp|Q9HFR0|CSN2_SCHPO COP9 signalosome complex subunit 2 OS=Schizosaccharomyces
pombe GN=csn2 PE=1 SV=1
Length = 437
Score = 397 bits (1019), Expect = 1e-109
Identities = 201/434 (46%), Positives = 293/434 (67%), Gaps = 8/434 (1%)
Frame = +3
Query: 180 MASDADMEDYGFEYSDDEQEEQDVDIENQYYSAKGMVETEPEAALSEFAEVV-KMEPDKA 356
M D + D+ FE DD+ E VD+EN YY++K + E PE+AL+ F +V K E ++
Sbjct: 6 MLEDDENYDFEFEDDDDDMIEPYVDVENCYYNSKSLKEENPESALTSFYSIVEKCEGEQN 65
Query: 357 EWGFKALKQTVKIYYRLGKYKEMMDAYREMLTYIK-SAVTRNYSEKCINNIMDFVSGSAS 533
EW FKALKQ KI ++L KY +M+ +Y+ +L Y ++T+NYSEK I NI+++ S+
Sbjct: 66 EWAFKALKQITKINFQLKKYDDMLQSYQRLLGYTNWLSITKNYSEKSIYNIVEY--ASSC 123
Query: 534 QNTGLLQEFYQTTLKALEEAKNERLWFKTNLKLCNIWFDIGEYRRMTKILKELHKSCQKE 713
+NT L++FY T KAL+ NERL K + + Y + +L+++H+ E
Sbjct: 124 ENTEFLEKFYDVTTKALQNLNNERLMLKVLMHVARFLLTQKNYHKFKYLLRQMHELLSDE 183
Query: 714 DGT-DDQKKGSQLLEVYAIEIQIYTETKDNKKLKQLYQKALAIKSAIPHPRIMGIIRECG 890
+ + DQ +G+ LLE+Y++EIQ+Y++ +DNK+LK+LYQ +L +K+AIPHPRIMGIIRECG
Sbjct: 184 NNSVADQNRGTHLLELYSLEIQMYSDIEDNKRLKELYQSSLRVKTAIPHPRIMGIIRECG 243
Query: 891 GKMHMAERQWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKP 1070
GKMHM E QW+EA T+FFE+FK+YDEAG+ RI+ LKYLVLANML ESE+NPFD E +P
Sbjct: 244 GKMHMQENQWSEAQTNFFESFKSYDEAGSSDRIRVLKYLVLANMLSESEINPFDSPETQP 303
Query: 1071 YKNDPEILAMTNLIAAYQRNEIIEFEKILKNNRRTIMDDPFIRNYMEDLLKKVRTQVLLK 1250
YK++P I+AMT L+ AYQ +I E+IL+ + I+DD FIR Y++ +L +R+QVL++
Sbjct: 304 YKDNPHIIAMTKLVEAYQIRDITAVERILQTYQHDILDDDFIRQYVDKILYSIRSQVLIE 363
Query: 1251 LIKPYTKIKIPFISKELNVPEKDVTELLVSLILDSRIDGHIDEINRYLLRGDSAN--GRK 1424
L+KPYT +K+ ++K+L V + + LV LI+D R++G ID +N N +
Sbjct: 364 LVKPYTSVKLSLLAKKLGVSISIIEQALVGLIIDERVNGKIDMVNEVFTISQPKNTIHNQ 423
Query: 1425 LHKAVDK-WNTQLK 1463
L + V K WNT K
Sbjct: 424 LVEDVQKLWNTATK 437
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,872,592,117
Number of Sequences: 518415
Number of Extensions: 81872592117
Number of Successful Extensions: 541474699
Number of sequences better than 0.0: 0
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