BLASTX 7.6.2
Query= UN20386 /QuerySize=1646
(1645 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q94KI8|TPC1_ARATH Two pore calcium channel protein 1 OS=Arabi... 920 5e-267
sp|Q75VR0|TPC1B_TOBAC Two pore calcium channel protein 1B OS=Nic... 690 8e-198
sp|Q75VR1|TPC1A_TOBAC Two pore calcium channel protein 1A OS=Nic... 687 9e-197
sp|Q5QM84|TPC1_ORYSJ Two pore calcium channel protein 1 OS=Oryza... 643 2e-183
sp|Q6YLX9|TPC1_WHEAT Two pore calcium channel protein 1 OS=Triti... 611 5e-174
sp|Q6S5H8|TPC1_HORVU Two pore calcium channel protein 1 OS=Horde... 606 2e-172
sp|Q9EQJ0|TPC1_MOUSE Two pore calcium channel protein 1 OS=Mus m... 107 2e-022
sp|Q9ULQ1|TPC1_HUMAN Two pore calcium channel protein 1 OS=Homo ... 107 4e-022
sp|Q9WTN5|TPC1_RAT Two pore calcium channel protein 1 OS=Rattus ... 104 2e-021
sp|Q8NHX9|TPC2_HUMAN Two pore calcium channel protein 2 OS=Homo ... 65 2e-009
sp|Q8BWC0|TPC2_MOUSE Two pore calcium channel protein 2 OS=Mus m... 63 5e-009
sp|A0JMD4|TPC2_DANRE Two pore calcium channel protein 2 OS=Danio... 60 4e-008
>sp|Q94KI8|TPC1_ARATH Two pore calcium channel protein 1 OS=Arabidopsis thaliana
GN=TPC1 PE=1 SV=1
Length = 733
Score = 920 bits (2377), Expect = 5e-267
Identities = 449/474 (94%), Positives = 466/474 (98%)
Frame = -3
Query: 1643 MFILFTTSNNPDVWIRAYKSSRWSSLFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVS 1464
MFILFTTSNNPDVWI AYKSSRWSS+FFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVS
Sbjct: 258 MFILFTTSNNPDVWIPAYKSSRWSSVFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVS 317
Query: 1463 GMDQMKRRMLEKAFGLIDKDKTGQIDKEQCIKLFEQLTNYRTLPKISKEEFGLIFDELDD 1284
GMDQMKRRMLEKAFGLID DK G+IDK QCIKLFEQLTNYRTLPKISKEEFGLIFDELDD
Sbjct: 318 GMDQMKRRMLEKAFGLIDSDKNGEIDKNQCIKLFEQLTNYRTLPKISKEEFGLIFDELDD 377
Query: 1283 TRDFKINKDEFADLCQAIALRFQKEEVPSLFENLPQIYHSALSQQLRAFVRSPNFGYTIS 1104
TRDFKINKDEFADLCQAIALRFQKEEVPSLFE+ PQIYHSALSQQLRAFVRSPNFGY IS
Sbjct: 378 TRDFKINKDEFADLCQAIALRFQKEEVPSLFEHFPQIYHSALSQQLRAFVRSPNFGYAIS 437
Query: 1103 FILVVNFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKIYSYGFENYWRDGQN 924
FIL++NFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKIY+YGFENYWR+G N
Sbjct: 438 FILIINFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKIYTYGFENYWREGAN 497
Query: 923 RFDFIVTWVIVIGETATFITPDENTLFSNGEWIRYLLLARMLRLIRLLMHVQRYRAFIAT 744
RFDF+VTWVIVIGETATFITPDENT FSNGEWIRYLLLARMLRLIRLLM+VQRYRAFIAT
Sbjct: 498 RFDFLVTWVIVIGETATFITPDENTFFSNGEWIRYLLLARMLRLIRLLMNVQRYRAFIAT 557
Query: 743 FITLIPSLMPYLGTIFCVLCIYCSIGVQIFGGLVNAGNKQLFKTEMAEDDYLLFNFNDYP 564
FITLIPSLMPYLGTIFCVLCIYCSIGVQ+FGGLVNAGNK+LF+TE+AEDDYLLFNFNDYP
Sbjct: 558 FITLIPSLMPYLGTIFCVLCIYCSIGVQVFGGLVNAGNKKLFETELAEDDYLLFNFNDYP 617
Query: 563 NGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYIITVLLLLNLVVAFVLEAFFT 384
NGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFY+IT+LLLLNLVVAFVLEAFFT
Sbjct: 618 NGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYVITILLLLNLVVAFVLEAFFT 677
Query: 383 ELDLEEEEKCQGQDSQERRNRRRSAGSKSRSQRVDTLLHHMLGDELSKPECSTT 222
ELDLEEEEKCQGQDSQE+RNRRRSAGSKSRSQRVDTLLHHMLGDELSKPECST+
Sbjct: 678 ELDLEEEEKCQGQDSQEKRNRRRSAGSKSRSQRVDTLLHHMLGDELSKPECSTS 731
>sp|Q75VR0|TPC1B_TOBAC Two pore calcium channel protein 1B OS=Nicotiana tabacum
GN=TPC1B PE=2 SV=1
Length = 735
Score = 690 bits (1780), Expect = 8e-198
Identities = 328/473 (69%), Positives = 391/473 (82%), Gaps = 3/473 (0%)
Frame = -3
Query: 1643 MFILFTTSNNPDVWIRAYKSSRWSSLFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVS 1464
MF+LFTTSNNPDVWI AYK SRW LFFVLYVL+GVYFVTNLILAVVYDSFK +L KQV+
Sbjct: 261 MFVLFTTSNNPDVWIPAYKDSRWYCLFFVLYVLLGVYFVTNLILAVVYDSFKSELVKQVA 320
Query: 1463 GMDQMKRRMLEKAFGLIDKDKTGQIDKEQCIKLFEQLTNYRTLPKISKEEFGLIFDELDD 1284
D+++ R L+KAF LID+ G ++++QC LFE+L YRTLPKIS ++F IF+ELDD
Sbjct: 321 DKDRLRLRTLKKAFSLIDEANNGLLNEKQCTLLFEELNKYRTLPKISGDDFKSIFNELDD 380
Query: 1283 TRDFKINKDEFADLCQAIALRFQKEEVPSLFENLPQIYHSALSQQLRAFVRSPNFGYTIS 1104
T DFKIN +EFADLC AI LRFQKE+ +FE P YHS S++LR F+R F Y I
Sbjct: 381 TGDFKINLEEFADLCSAIGLRFQKEDSLPIFEACPNFYHSPASEKLRGFIRGATFEYIIV 440
Query: 1103 FILVVNFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKIYSYGFENYWRDGQN 924
F+L+VN +AV++ETTLDI+ +S Q WQ EF FGW+YV+EMALK+Y+YGFENYWRDGQN
Sbjct: 441 FVLLVNLVAVIIETTLDIQNNSGQTFWQKVEFTFGWLYVIEMALKVYTYGFENYWRDGQN 500
Query: 923 RFDFIVTWVIVIGETATFITPDENTLFSNGEWIRYLLLARMLRLIRLLMHVQRYRAFIAT 744
RFDFIVTWVIVIGET TF+ PD+ T SNGEWIRYLL+ARMLRLIRLLMHV+RYRAF+AT
Sbjct: 501 RFDFIVTWVIVIGETTTFVAPDDLTFLSNGEWIRYLLIARMLRLIRLLMHVERYRAFVAT 560
Query: 743 FITLIPSLMPYLGTIFCVLCIYCSIGVQIFGGLVNAGNKQLFKTEMAEDDYLLFNFNDYP 564
F+TLIPSLMPYLGTIFC+LC YCS+G+QIFGG+VN GN L +T++A +DYLLFNFNDYP
Sbjct: 561 FLTLIPSLMPYLGTIFCILCFYCSLGLQIFGGIVNTGNPNLAQTDLAGNDYLLFNFNDYP 620
Query: 563 NGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYIITVLLLLNLVVAFVLEAFFT 384
NGMVTLFN+LVMGNWQVWM+SYK+LTGT W+ YFVSFY+I+VL LLNL+VAFVLEAF
Sbjct: 621 NGMVTLFNILVMGNWQVWMQSYKELTGTSWTYAYFVSFYLISVLWLLNLIVAFVLEAFQA 680
Query: 383 ELDLEEEEKC-QGQDSQERRNRRRSAGSKSRSQRVDTLLHHMLGDELSKPECS 228
E+DLE +C G D + +R RRR+ G+K+RSQRVD LLHHML EL+ ECS
Sbjct: 681 EMDLEASARCVDGDDKEAKRERRRNVGTKTRSQRVDFLLHHMLRSELT--ECS 731
>sp|Q75VR1|TPC1A_TOBAC Two pore calcium channel protein 1A OS=Nicotiana tabacum
GN=TPC1A PE=2 SV=1
Length = 735
Score = 687 bits (1771), Expect = 9e-197
Identities = 328/473 (69%), Positives = 388/473 (82%), Gaps = 3/473 (0%)
Frame = -3
Query: 1643 MFILFTTSNNPDVWIRAYKSSRWSSLFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVS 1464
MF+LFTTSNNPDVWI AYK SRW LFFVLYVL+GVYFVTNLILAVVYDSFK +L KQV+
Sbjct: 261 MFVLFTTSNNPDVWIPAYKDSRWYCLFFVLYVLLGVYFVTNLILAVVYDSFKSELVKQVA 320
Query: 1463 GMDQMKRRMLEKAFGLIDKDKTGQIDKEQCIKLFEQLTNYRTLPKISKEEFGLIFDELDD 1284
D+++ R L+KAF LID+ G ++++QC LFE+L YRTLPKIS ++F IF ELDD
Sbjct: 321 DKDRLRLRTLKKAFSLIDEANNGHLNEKQCTLLFEELNKYRTLPKISGDDFKSIFSELDD 380
Query: 1283 TRDFKINKDEFADLCQAIALRFQKEEVPSLFENLPQIYHSALSQQLRAFVRSPNFGYTIS 1104
T DFKIN DEFADLC AI LRFQKE+ +FE P YHS S++LR FVR F Y I
Sbjct: 381 TGDFKINLDEFADLCTAIGLRFQKEDSLPIFEACPNFYHSPASEKLRGFVRGATFEYIIV 440
Query: 1103 FILVVNFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKIYSYGFENYWRDGQN 924
F+L+VN +AV++ETTLDI+ +S Q WQ EF FGW+YV+EMALK+Y+YGFENYWRDGQN
Sbjct: 441 FVLLVNLVAVIIETTLDIQNNSGQTFWQKVEFTFGWLYVIEMALKVYTYGFENYWRDGQN 500
Query: 923 RFDFIVTWVIVIGETATFITPDENTLFSNGEWIRYLLLARMLRLIRLLMHVQRYRAFIAT 744
RFDF+VTWVIVIGETATF+ PD T SNGEWIRYLL+ARMLRLIRLLMHV+RYRAF+AT
Sbjct: 501 RFDFVVTWVIVIGETATFVAPDGLTFLSNGEWIRYLLIARMLRLIRLLMHVERYRAFVAT 560
Query: 743 FITLIPSLMPYLGTIFCVLCIYCSIGVQIFGGLVNAGNKQLFKTEMAEDDYLLFNFNDYP 564
F TLIPSL+PYLGTIFC+LC YCS+G+QIFGG+VN GN L +T++A +DYLLFNFNDYP
Sbjct: 561 FFTLIPSLVPYLGTIFCILCFYCSLGLQIFGGIVNTGNPNLAQTDLAGNDYLLFNFNDYP 620
Query: 563 NGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYIITVLLLLNLVVAFVLEAFFT 384
NGMVTLFN+LVMGNWQVWM+SYK+LTGT W+ YFVSFY+I+VL LLNL+VAFVLEAF
Sbjct: 621 NGMVTLFNILVMGNWQVWMQSYKELTGTAWTYAYFVSFYLISVLWLLNLIVAFVLEAFQA 680
Query: 383 ELDLEEEEKC-QGQDSQERRNRRRSAGSKSRSQRVDTLLHHMLGDELSKPECS 228
E+DLE +C G D + + RRR+ G+K+RSQRVD LLHHML EL+ ECS
Sbjct: 681 EVDLEASARCVDGDDKEAKSERRRNVGTKTRSQRVDFLLHHMLRSELT--ECS 731
>sp|Q5QM84|TPC1_ORYSJ Two pore calcium channel protein 1 OS=Oryza sativa subsp.
japonica GN=TPC1 PE=1 SV=2
Length = 757
Score = 643 bits (1657), Expect = 2e-183
Identities = 304/467 (65%), Positives = 378/467 (80%), Gaps = 1/467 (0%)
Frame = -3
Query: 1643 MFILFTTSNNPDVWIRAYKSSRWSSLFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVS 1464
MFILFTTSNNPDVW+ AYKSSRWSSLFF++YVL+GVYF+TNLILAV+YDSFKEQLAKQVS
Sbjct: 283 MFILFTTSNNPDVWVPAYKSSRWSSLFFIVYVLLGVYFLTNLILAVIYDSFKEQLAKQVS 342
Query: 1463 GMDQMKRRMLEKAFGLIDKDKTGQIDKEQCIKLFEQLTNYRTLPKISKEEFGLIFDELDD 1284
D ++ +LEKAFG+ID G ++KEQC+ L ++L YR+LPK S+E+F LIF ELD
Sbjct: 343 QADCTRKSILEKAFGIIDATGQGYLNKEQCLSLLDELNKYRSLPKTSREDFELIFAELDQ 402
Query: 1283 TRDFKINKDEFADLCQAIALRFQKEEVPSLFENLPQIYHSALSQQLRAFVRSPNFGYTIS 1104
+ DFK+ +EFA LC IA++FQKE PS E P YHSAL + L++FVRSP F Y +
Sbjct: 403 SGDFKVTSEEFATLCNTIAIKFQKEPPPSYLEKYPSFYHSALCEWLKSFVRSPLFEYIVI 462
Query: 1103 FILVVNFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKIYSYGFENYWRDGQN 924
F+L++N +AV++ETTLDIE SS+QK WQ EFVFGWIYV+EMALKI+S GF YW +GQN
Sbjct: 463 FVLLMNLVAVIIETTLDIENSSSQKVWQEVEFVFGWIYVIEMALKIFSLGFGAYWMEGQN 522
Query: 923 RFDFIVTWVIVIGETATFITPDENTLFSNGEWIRYLLLARMLRLIRLLMHVQRYRAFIAT 744
+FDF++TW I IGET TF P + + SNGEWIRYLLL RMLRL R+L+ V+R+RAF+AT
Sbjct: 523 KFDFVLTWTIFIGETLTFAFPSKLSFLSNGEWIRYLLLGRMLRLTRILLQVRRFRAFVAT 582
Query: 743 FITLIPSLMPYLGTIFCVLCIYCSIGVQIFGGLVNAGNKQLFKTEMAEDDYLLFNFNDYP 564
F TL+ SLMPYLG +FC LCIYCS+G+QIFGG+V AGN L +T++ +DYLLFNFNDYP
Sbjct: 583 FFTLMSSLMPYLGIVFCTLCIYCSLGLQIFGGIVYAGNPTLEETDLFSNDYLLFNFNDYP 642
Query: 563 NGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYIITVLLLLNLVVAFVLEAFFT 384
+GMVTLFNLLVMGNWQ WMESY+ LTG++WS+ YFVSFY+I+VLLLLNL+VAFVLEAFF
Sbjct: 643 SGMVTLFNLLVMGNWQAWMESYRQLTGSYWSLIYFVSFYLISVLLLLNLIVAFVLEAFFA 702
Query: 383 ELDLEEEEKCQGQD-SQERRNRRRSAGSKSRSQRVDTLLHHMLGDEL 246
E++LE++ + QD + E RNRRRS +++ VD LLHHML +EL
Sbjct: 703 EMELEKDGEADIQDPTLEGRNRRRSVRVRTKGTMVDILLHHMLSNEL 749
>sp|Q6YLX9|TPC1_WHEAT Two pore calcium channel protein 1 OS=Triticum aestivum
GN=TPC1 PE=2 SV=1
Length = 742
Score = 611 bits (1575), Expect = 5e-174
Identities = 293/467 (62%), Positives = 366/467 (78%), Gaps = 2/467 (0%)
Frame = -3
Query: 1643 MFILFTTSNNPDVWIRAYKSSRWSSLFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVS 1464
MF+LFTTSNNPDVW+ AYK RW SLFF++YVL+GVYF+TNLILAV+YDSFKEQ AKQ+
Sbjct: 271 MFVLFTTSNNPDVWVHAYKIPRWYSLFFIVYVLLGVYFLTNLILAVIYDSFKEQFAKQLV 330
Query: 1463 GMDQMKRRMLEKAFGLIDKDKTGQIDKEQCIKLFEQLTNYRTLPKISKEEFGLIFDELDD 1284
+D +++ +L+KAF LID + G +D+EQCI L +L YR+LPK S+E+F LIF ELD
Sbjct: 331 QVDSIRKNILQKAFDLIDTNNRGYLDREQCISLLNELNKYRSLPKTSREDFELIFAELDR 390
Query: 1283 TRDFKINKDEFADLCQAIALRFQKEEVPSLFENLPQIYHSALSQQLRAFVRSPNFGYTIS 1104
+ DFK+ +EFADLC IA++FQKE PS E P YHS L +L++FVRS F Y I
Sbjct: 391 SGDFKVTSEEFADLCNTIAIKFQKEPPPSYLEKFP-FYHSPLCGRLKSFVRSRMFEYIIV 449
Query: 1103 FILVVNFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKIYSYGFENYWRDGQN 924
F+L++N +AV++ETTLDIE SS+Q+ WQ EF GWIYV EMALKI+S GF YW +GQN
Sbjct: 450 FVLLINLVAVIIETTLDIENSSSQETWQEVEFFLGWIYVAEMALKIFSLGFGAYWMEGQN 509
Query: 923 RFDFIVTWVIVIGETATFITPDENTLFSNGEWIRYLLLARMLRLIRLLMHVQRYRAFIAT 744
+FDF++TW I IGET TF P + SNGEWIRYLLL R+LRL R+L+ VQR+RAF+AT
Sbjct: 510 KFDFVLTWTIFIGETLTFAFPSKLPFLSNGEWIRYLLLGRVLRLTRILLQVQRFRAFVAT 569
Query: 743 FITLIPSLMPYLGTIFCVLCIYCSIGVQIFGGLVNAGNKQLFKTEMAEDDYLLFNFNDYP 564
F TL+ SLMPYLG +FCVLC+YCSIG+QIFGG+V AGN L +T++ +DYLLFNFNDYP
Sbjct: 570 FFTLMSSLMPYLGIVFCVLCMYCSIGLQIFGGIVYAGNPTLEETDLFNNDYLLFNFNDYP 629
Query: 563 NGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYIITVLLLLNLVVAFVLEAFFT 384
+GMVTLFNLLVMGNWQVWMESY LTGT WS+ YFVSFY+I++LLLLNL+VAFVLEAFF
Sbjct: 630 SGMVTLFNLLVMGNWQVWMESYWQLTGTSWSLIYFVSFYLISILLLLNLIVAFVLEAFFA 689
Query: 383 ELDLEEEEKCQGQD-SQERRNRRRSAGSKSRSQRVDTLLHHMLGDEL 246
E++LE+ E+ Q+ + +RRS +S+ VD LLHHML +EL
Sbjct: 690 EMELEKGEEVDIQNPTSGGIKKRRSMRVRSKGTMVDILLHHMLSNEL 736
>sp|Q6S5H8|TPC1_HORVU Two pore calcium channel protein 1 OS=Hordeum vulgare
GN=TPC1 PE=2 SV=1
Length = 742
Score = 606 bits (1562), Expect = 2e-172
Identities = 289/467 (61%), Positives = 365/467 (78%), Gaps = 2/467 (0%)
Frame = -3
Query: 1643 MFILFTTSNNPDVWIRAYKSSRWSSLFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVS 1464
MF+LFTTSNNPDVW+ AYK SRW SLFF++YVL+GVYF+TNLILAV+YDSFKEQ AKQ+
Sbjct: 271 MFVLFTTSNNPDVWVPAYKISRWYSLFFIVYVLLGVYFLTNLILAVIYDSFKEQFAKQLV 330
Query: 1463 GMDQMKRRMLEKAFGLIDKDKTGQIDKEQCIKLFEQLTNYRTLPKISKEEFGLIFDELDD 1284
+D +++ +L+KAF LID + G +D+EQCI L +L YR+LPK S+E+F LIF ELD
Sbjct: 331 QVDAIRKNILQKAFELIDTNTRGYLDREQCISLLNELNKYRSLPKTSREDFELIFAELDR 390
Query: 1283 TRDFKINKDEFADLCQAIALRFQKEEVPSLFENLPQIYHSALSQQLRAFVRSPNFGYTIS 1104
+ DFK+ +EFADLC IA++FQKE PS E P YHS + +L++FVRS F Y I
Sbjct: 391 SGDFKVTSEEFADLCNTIAIKFQKEPPPSYLEKFP-FYHSPVCGRLKSFVRSRTFEYIIV 449
Query: 1103 FILVVNFIAVVVETTLDIEESSAQKPWQVAEFVFGWIYVLEMALKIYSYGFENYWRDGQN 924
F+L++N +AV++ETTLDIE SS+Q+ WQ EF GWIYV EMALKI+S GF YW +GQN
Sbjct: 450 FVLLINLVAVIIETTLDIENSSSQETWQEVEFFLGWIYVAEMALKIFSLGFGAYWMEGQN 509
Query: 923 RFDFIVTWVIVIGETATFITPDENTLFSNGEWIRYLLLARMLRLIRLLMHVQRYRAFIAT 744
+FDF++TW I IGET TF P + SNGEWIRYLLL R+LRL R+L+ VQR+R F+AT
Sbjct: 510 KFDFVLTWTIFIGETLTFAFPSKLPFLSNGEWIRYLLLGRVLRLTRILLQVQRFRVFVAT 569
Query: 743 FITLIPSLMPYLGTIFCVLCIYCSIGVQIFGGLVNAGNKQLFKTEMAEDDYLLFNFNDYP 564
F TL+ SLMPYLG +FC+LC+YCS+G+QIFGG+V AGN L +T++ +DYLLFNFNDYP
Sbjct: 570 FFTLMSSLMPYLGIVFCILCMYCSLGLQIFGGIVYAGNPTLEETDLFSNDYLLFNFNDYP 629
Query: 563 NGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYIITVLLLLNLVVAFVLEAFFT 384
+GMVTLFNLLVMGNWQVWMESY LTG+ WS+ YFVSFY+I++LLLLNL+VAFVLEAFF
Sbjct: 630 SGMVTLFNLLVMGNWQVWMESYWQLTGSSWSLIYFVSFYLISILLLLNLIVAFVLEAFFA 689
Query: 383 ELDLEEEEKCQGQD-SQERRNRRRSAGSKSRSQRVDTLLHHMLGDEL 246
E++LE+ E+ Q + +RRS +S+ VD LLHHML +EL
Sbjct: 690 EMELEKGEEVDIQSPTSGGIKKRRSMRVRSKGTMVDILLHHMLSNEL 736
>sp|Q9EQJ0|TPC1_MOUSE Two pore calcium channel protein 1 OS=Mus musculus
GN=Tpcn1 PE=2 SV=1
Length = 817
Score = 107 bits (267), Expect = 2e-022
Identities = 77/257 (29%), Positives = 133/257 (51%), Gaps = 12/257 (4%)
Frame = -3
Query: 1643 MFILFTTSNNPDVWIRAYKSSRWSSLFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVS 1464
+F+L TT+N PDV + +Y + WS +FF++Y+ I +YF+ NL+LAVV+D+F + +
Sbjct: 274 LFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKHKFK 333
Query: 1463 GMDQMKRRMLEKAFGLI-DKDKTGQIDKEQCIKLFEQLTNYRTLPKISKEEFGLIFDELD 1287
+ KR ++ A+GL+ + + I Q FE L + P++S E L F L+
Sbjct: 334 SLLLHKRTAIQHAYGLLASQRRPAGISYRQ----FEGLMRFYK-PRMSARERFLTFKALN 388
Query: 1286 DTRDFKINKDEFADLCQAIALRFQ-KEEVPSLFENLPQIYHSALSQQLRAFVRSPNFGYT 1110
+ ++ +F D+ + AL+++ K F+ LP+ + + + V S F Y
Sbjct: 389 QSNTPLLSLKDFYDIYEVAALQWKAKRNRQHWFDELPRTAF-LIFKGINILVNSKAFQYF 447
Query: 1109 ISFILVVNFIAVVVETTL--DIEESSAQKPWQVAEFVFGWIYVLEMALKIYSYGFENYWR 936
+ ++ VN + ++VET + +S PW + VF IY +E+ +K+ G Y
Sbjct: 448 MYLVVAVNGVWILVETFMLKGGNFTSKHVPW--SYLVFLTIYGVELFMKVAGLGPVEYLS 505
Query: 935 DGQNRFDFIVTWVIVIG 885
G N FDF VT +G
Sbjct: 506 SGWNLFDFSVTAFAFLG 522
Score = 69 bits (166), Expect = 1e-010
Identities = 36/93 (38%), Positives = 57/93 (61%), Gaps = 2/93 (2%)
Frame = -3
Query: 617 KTEMAEDDYLLFNFNDYPNGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYIIT 438
KT++ E Y L NF++ N VTLF L V+ NW + ME T + WS YF++FYI+T
Sbjct: 618 KTKVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT-SHWSRLYFMTFYIVT 676
Query: 437 VLLLLNLVVAFVLEAFFTELDLEEEEKCQGQDS 339
++++ ++VAF+LEAF ++ + + DS
Sbjct: 677 -MVVMTIIVAFILEAFVFRMNYSRKSQDSEVDS 708
>sp|Q9ULQ1|TPC1_HUMAN Two pore calcium channel protein 1 OS=Homo sapiens
GN=TPCN1 PE=2 SV=3
Length = 816
Score = 107 bits (265), Expect = 4e-022
Identities = 78/257 (30%), Positives = 133/257 (51%), Gaps = 12/257 (4%)
Frame = -3
Query: 1643 MFILFTTSNNPDVWIRAYKSSRWSSLFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVS 1464
+F+L TT+N PDV + +Y + WS +FF++Y+ I +YF+ NL+LAVV+D+F + ++
Sbjct: 273 LFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFK 332
Query: 1463 GMDQMKRRMLEKAFG-LIDKDKTGQIDKEQCIKLFEQLTNYRTLPKISKEEFGLIFDELD 1287
+ KR ++ A+ LI + + I Q FE L + P++S E L F L+
Sbjct: 333 SLLLHKRTAIQHAYRLLISQRRPAGISYRQ----FEGLMRFYK-PRMSARERYLTFKALN 387
Query: 1286 DTRDFKINKDEFADLCQAIALRFQ-KEEVPSLFENLPQIYHSALSQQLRAFVRSPNFGYT 1110
++ +F D+ + AL+++ K+ F+ LP+ + + + V+S F Y
Sbjct: 388 QNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRT-ALLIFKGINILVKSKAFQYF 446
Query: 1109 ISFILVVNFIAVVVETTL--DIEESSAQKPWQVAEFVFGWIYVLEMALKIYSYGFENYWR 936
+ ++ VN + ++VET + S PW + VF IY +E+ LK+ G Y
Sbjct: 447 MYLVVAVNGVWILVETFMLKGGNFFSKHVPW--SYLVFLTIYGVELFLKVAGLGPVEYLS 504
Query: 935 DGQNRFDFIVTWVIVIG 885
G N FDF VT +G
Sbjct: 505 SGWNLFDFSVTVFAFLG 521
Score = 65 bits (158), Expect = 1e-009
Identities = 36/94 (38%), Positives = 57/94 (60%), Gaps = 6/94 (6%)
Frame = -3
Query: 617 KTEMAEDDYLLFNFNDYPNGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYIIT 438
+T + E Y L NF++ N VTLF L V+ NW + ME T + WS YF++FYI+T
Sbjct: 617 RTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT-SHWSRLYFMTFYIVT 675
Query: 437 VLLLLNLVVAFVLEAFFTELDLEEEEKCQGQDSQ 336
++++ ++VAF+LEAF ++ + QDS+
Sbjct: 676 -MVVMTIIVAFILEAFVFRMNYSR----KNQDSE 704
>sp|Q9WTN5|TPC1_RAT Two pore calcium channel protein 1 OS=Rattus norvegicus
GN=Tpcn1 PE=1 SV=2
Length = 817
Score = 104 bits (259), Expect = 2e-021
Identities = 76/257 (29%), Positives = 133/257 (51%), Gaps = 12/257 (4%)
Frame = -3
Query: 1643 MFILFTTSNNPDVWIRAYKSSRWSSLFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVS 1464
+F+L TT+N PDV + +Y + WS +FF++Y+ I +YF+ NL+LAVV+D+F + +
Sbjct: 274 LFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKHKFK 333
Query: 1463 GMDQMKRRMLEKAFG-LIDKDKTGQIDKEQCIKLFEQLTNYRTLPKISKEEFGLIFDELD 1287
+ KR ++ A+ L+ + + I Q FE L + P++S E L F L+
Sbjct: 334 SLLLHKRTAIQHAYHLLVSQRRPAGISYRQ----FEGLMRFYK-PRMSARERFLTFKALN 388
Query: 1286 DTRDFKINKDEFADLCQAIALRFQ-KEEVPSLFENLPQIYHSALSQQLRAFVRSPNFGYT 1110
+ ++ +F D+ + AL+++ K+ F+ LP+ + + + V S F Y
Sbjct: 389 QSNTPLLSLKDFYDIYEVAALQWKAKKNRQHWFDELPRTAF-LIFKGINILVNSKAFQYF 447
Query: 1109 ISFILVVNFIAVVVETTLDIEESSAQK--PWQVAEFVFGWIYVLEMALKIYSYGFENYWR 936
+ ++ VN + ++VET + + K PW + VF IY +E+ +K+ G Y
Sbjct: 448 MYLVVAVNGVWILVETFMLKGGNFISKHVPW--SYLVFLTIYGVELFMKVAGLGPVEYLS 505
Query: 935 DGQNRFDFIVTWVIVIG 885
G N FDF VT +G
Sbjct: 506 SGWNLFDFSVTAFAFLG 522
Score = 68 bits (165), Expect = 2e-010
Identities = 36/93 (38%), Positives = 57/93 (61%), Gaps = 2/93 (2%)
Frame = -3
Query: 617 KTEMAEDDYLLFNFNDYPNGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYIIT 438
KT++ E Y L NF++ N VTLF L V+ NW + ME T + WS YF++FYI+T
Sbjct: 618 KTKVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT-SHWSRLYFMTFYIVT 676
Query: 437 VLLLLNLVVAFVLEAFFTELDLEEEEKCQGQDS 339
++++ ++VAF+LEAF ++ + + DS
Sbjct: 677 -MVVMTIIVAFILEAFVFRMNYSRKSQESEVDS 708
>sp|Q8NHX9|TPC2_HUMAN Two pore calcium channel protein 2 OS=Homo sapiens
GN=TPCN2 PE=2 SV=2
Length = 752
Score = 65 bits (156), Expect = 2e-009
Identities = 28/74 (37%), Positives = 52/74 (70%), Gaps = 1/74 (1%)
Frame = -3
Query: 596 DYLLFNFNDYPNGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYIITVLLLLNL 417
+Y NF+D+ +VTL+NL+V+ NWQV++++Y+ +G W I YFV +++++ ++ +NL
Sbjct: 630 EYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKI-YFVLWWLVSSVIWVNL 688
Query: 416 VVAFVLEAFFTELD 375
+A +LE F + D
Sbjct: 689 FLALILENFLHKWD 702
Score = 59 bits (140), Expect = 1e-007
Identities = 24/59 (40%), Positives = 40/59 (67%)
Frame = -3
Query: 1643 MFILFTTSNNPDVWIRAYKSSRWSSLFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQV 1467
+ +L TT+NNPDV I AY +R ++FF+++ +IG F+ NL+ A++Y F+ L K +
Sbjct: 265 LLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSL 323
>sp|Q8BWC0|TPC2_MOUSE Two pore calcium channel protein 2 OS=Mus musculus
GN=Tpcn2 PE=2 SV=1
Length = 731
Score = 63 bits (152), Expect = 5e-009
Identities = 27/69 (39%), Positives = 48/69 (69%), Gaps = 1/69 (1%)
Frame = -3
Query: 581 NFNDYPNGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYIITVLLLLNLVVAFV 402
NF+D+ ++TL+N++V+ NWQV +E+YK G WS+ YFV +++++ ++ +NL +A +
Sbjct: 618 NFDDFAAALITLWNVMVVNNWQVILEAYKRYAGP-WSMVYFVLWWLVSSVIWINLFLALL 676
Query: 401 LEAFFTELD 375
LE F D
Sbjct: 677 LENFLHRWD 685
Score = 62 bits (148), Expect = 1e-008
Identities = 27/59 (45%), Positives = 41/59 (69%)
Frame = -3
Query: 1643 MFILFTTSNNPDVWIRAYKSSRWSSLFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQV 1467
+ +L TTSNNPDV I AY +R +LFF+++ LIG F+ NL+ A++Y+ F+ L K +
Sbjct: 249 LLVLLTTSNNPDVMIPAYTQNRAFALFFIVFTLIGSLFLMNLLTAIIYNQFRGYLMKSL 307
>sp|A0JMD4|TPC2_DANRE Two pore calcium channel protein 2 OS=Danio rerio GN=tpcn2
PE=2 SV=1
Length = 774
Score = 60 bits (144), Expect = 4e-008
Identities = 28/77 (36%), Positives = 46/77 (59%)
Frame = -3
Query: 1643 MFILFTTSNNPDVWIRAYKSSRWSSLFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVS 1464
+ +L TT+NNPDV I AY +R S+FF+L+ + G Y + NL+ A++Y+ F+ L V
Sbjct: 278 LLVLLTTANNPDVMIPAYSLNRGYSIFFILFSVFGTYLLMNLMTAIIYNQFRGYLLMSVQ 337
Query: 1463 GMDQMKRRMLEKAFGLI 1413
+R + AF ++
Sbjct: 338 TSIIRRRLGIRAAFEVL 354
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,450,105,564
Number of Sequences: 518415
Number of Extensions: 83450105564
Number of Successful Extensions: 573192055
Number of sequences better than 0.0: 0
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