BLASTX 7.6.2
Query= UN20420 /QuerySize=1851
(1850 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9LYT3|TT12_ARATH Protein TRANSPARENT TESTA 12 OS=Arabidopsis... 477 2e-133
sp|A7KAU2|S47A1_RABIT Multidrug and toxin extrusion protein 1 OS... 239 6e-062
sp|A4IIS8|S47A1_XENTR Multidrug and toxin extrusion protein 1 OS... 237 2e-061
sp|Q9USK3|YJ2D_SCHPO Uncharacterized transporter C4B3.13 OS=Schi... 235 1e-060
sp|Q8K0H1|S47A1_MOUSE Multidrug and toxin extrusion protein 1 OS... 233 3e-060
sp|Q5I0E9|S47A1_RAT Multidrug and toxin extrusion protein 1 OS=R... 228 1e-058
sp|Q5RFD2|S47A1_PONAB Multidrug and toxin extrusion protein 1 OS... 228 2e-058
sp|Q3V050|S47A2_MOUSE Multidrug and toxin extrusion protein 2 OS... 228 2e-058
sp|Q96FL8|S47A1_HUMAN Multidrug and toxin extrusion protein 1 OS... 227 2e-058
sp|A1L1P9|S47A1_DANRE Multidrug and toxin extrusion protein 1 OS... 222 1e-056
sp|Q9UT92|YL47_SCHPO Uncharacterized transporter C323.07c OS=Sch... 213 4e-054
sp|A7KAU3|S47A2_RABIT Multidrug and toxin extrusion protein 2 OS... 209 6e-053
sp|Q10085|YAO6_SCHPO Uncharacterized transporter C11D3.06 OS=Sch... 208 1e-052
sp|Q05497|YD338_YEAST Uncharacterized transporter YDR338C OS=Sac... 170 4e-041
sp|Q86VL8|S47A2_HUMAN Multidrug and toxin extrusion protein 2 OS... 141 3e-032
sp|Q5R7E4|S47A2_PONAB Multidrug and toxin extrusion protein 2 OS... 122 8e-027
>sp|Q9LYT3|TT12_ARATH Protein TRANSPARENT TESTA 12 OS=Arabidopsis thaliana
GN=TT12 PE=2 SV=1
Length = 507
Score = 477 bits (1226), Expect = 2e-133
Identities = 245/501 (48%), Positives = 341/501 (68%), Gaps = 7/501 (1%)
Frame = +1
Query: 133 YQPLL-HPPADGRVPLSPSTESSNGELERVLSDVEIPLFHR-LRKATMIESKLLFKLAAP 306
Y+PLL +D ++ TE S+ E+E L + R K + ESKLL+ L+
Sbjct: 7 YEPLLTRLHSDSQI-----TERSSPEIEEFLRRRGSTVTPRWWLKLAVWESKLLWTLSGA 61
Query: 307 AVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMGSAVETLCGQAF 486
+++V ++NY++S T +F+GHLG+L+LA AS+ GIQ AYG+MLGM SAV+T+CGQA+
Sbjct: 62 SIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVGIQGLAYGIMLGMASAVQTVCGQAY 121
Query: 487 GGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASAASIFVYGLIPQ 666
G R+Y +GI QR+ VL V LT +Y +S PIL +G+S IA IF G+IPQ
Sbjct: 122 GARQYSSMGIICQRAMVLHLAAAVFLTFLYWYSGPILKTMGQSVAIAHEGQIFARGMIPQ 181
Query: 667 IFAYAVNFPIQKFLQSQSIVAPSAYISTATLFVHLLLSWLAIYKLGMGLLGASLVLSLSW 846
I+A+A+ P+Q+FLQ+Q+IV P AY+S +H LL+WL L GLLGA+L+LS SW
Sbjct: 182 IYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTWLVTNVLDFGLLGAALILSFSW 241
Query: 847 WIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLCLETWYFQILVLLA 1026
W++V +YI+ S C+ETW GFS +AF G+ +FKL+ ASAVMLCLE WY Q LV+++
Sbjct: 242 WLLVAVNGMYILMSPNCKETWTGFSTRAFRGIWPYFKLTVASAVMLCLEIWYNQGLVIIS 301
Query: 1027 GLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAGNPKSASFSVIIVNIY 1206
GLL NP ++LD++SICM W +G +AAISVRVSNELGAGNP+ A SV++VNI
Sbjct: 302 GLLSNPTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNIT 361
Query: 1207 SLITCVILAIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLVLNGIQPVLSGVAVGC 1386
+++ +L +++L FR LS AFT EV AAVSDL PLLA+++ LNGIQP+LSGVA+G
Sbjct: 362 TVLISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGS 421
Query: 1387 GWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTLIQTVILAWVTFRTDW 1566
GWQ VA VN+ YY+IG+P+G + GF GIW GMI G ++QT+ L +T +T+W
Sbjct: 422 GWQAVVAYVNLVTYYVIGLPIGCVLGFKTSLGVAGIWWGMIAGVILQTLTLIVLTLKTNW 481
Query: 1567 TKEVEEASKRLDKWSNKKLEV 1629
T EVE A++R+ + + E+
Sbjct: 482 TSEVENAAQRVKTSATENQEM 502
>sp|A7KAU2|S47A1_RABIT Multidrug and toxin extrusion protein 1 OS=Oryctolagus
cuniculus GN=SLC47A1 PE=2 SV=1
Length = 568
Score = 239 bits (609), Expect = 6e-062
Identities = 131/438 (29%), Positives = 239/438 (54%), Gaps = 2/438 (0%)
Frame = +1
Query: 274 ESKLLFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMG 453
E + L LA PA + ++ +L+S + +F GHL LEL A +L I + + G+
Sbjct: 33 ELRALLVLACPAFLAQLMVFLISFVSSVFCGHLSKLELNAVTLAIAVINVMGVSVGFGLS 92
Query: 454 SAVETLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASA 633
SA +TL Q +G R + +G+ LQR +++L L + +++ ++ ILL + P ++
Sbjct: 93 SACDTLISQTYGSRNLKHVGVILQRGSLILLLCCLPCWALFLNTQHILLLFRQDPAVSRL 152
Query: 634 ASIFVYGLIPQIFAYAVNFPIQKFLQSQSIVAPSAYISTATLFVHLLLSWLAIYKLGMGL 813
+V IP + A + K+L +Q IV P A V+ L ++L +Y+L +G+
Sbjct: 153 TQTYVTIFIPALPATFLYTLQVKYLLNQGIVLPQVVTGVAANLVNALANYLFVYQLHLGV 212
Query: 814 LGASLVLSLSWWIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLCLE 993
+G++L +++ + + + F+YI+ S+ + TW G+S++ SFF+L+ S +MLC+E
Sbjct: 213 MGSALANTVAQFTLALLLFLYILRSKVYQATWGGWSLECLQDWASFFRLAIPSMLMLCME 272
Query: 994 TWYFQILVLLAGLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAGNPKS 1173
W ++I L+G+L EL S++ + + V+MI +G + A++VRV N LGAGN +
Sbjct: 273 WWAYEIGSFLSGILGMVELGAQSVTYELAVI--VYMIPMGLSVAVNVRVGNALGAGNIEQ 330
Query: 1174 ASFSVIIVNIYSLITCVILAIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLVLNGI 1353
A S + + + + V+ +++L+ +D++ Y FT ++ A V+ + P+ A++ + +
Sbjct: 331 AKKSSAVALLVTELIAVVFCVMLLSCKDLVGYIFTSDRDIIALVAQVTPIYAVSHLFESL 390
Query: 1354 QPVLSGVAVGCGWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTLIQTV 1533
G+ G G Q F A VN YY++G+P+G F K G+W G++ + Q V
Sbjct: 391 AGTSGGILRGSGNQKFGAIVNAIGYYVVGLPIGIALMFAAKLGVIGLWLGIVVCAVSQAV 450
Query: 1534 ILAWVTFRTDWTKEVEEA 1587
R +WTK ++A
Sbjct: 451 CFLGFIARLNWTKACQQA 468
>sp|A4IIS8|S47A1_XENTR Multidrug and toxin extrusion protein 1 OS=Xenopus
tropicalis GN=slc47a1 PE=2 SV=1
Length = 574
Score = 237 bits (604), Expect = 2e-061
Identities = 139/441 (31%), Positives = 236/441 (53%), Gaps = 2/441 (0%)
Frame = +1
Query: 274 ESKLLFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMG 453
E++ L LAAPA + ++ +L+S+ + IF GHLG +EL A SL T I I + G+
Sbjct: 48 EAQQLLALAAPAFLSQLMIFLISIVSSIFCGHLGKVELDAVSLAITIINITGVAVGTGLA 107
Query: 454 SAVETLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASA 633
A +TL Q FGG +++GI LQR ++L L + + ++ ILL + PE++
Sbjct: 108 GACDTLISQTFGGSNLKLVGIILQRGILILLLFCFPCWALLINTESILLLFRQDPEVSKL 167
Query: 634 ASIFVYGLIPQIFAYAVNFPIQKFLQSQSIVAPSAYISTATLFVHLLLSWLAIYKLGMGL 813
I+V +P + A + + K+LQ+Q I+ P + L +++ +Y LG+G+
Sbjct: 168 TQIYVLIFLPALPAAFLYQLLAKYLQNQGIIYPQVLTGFIANIFNALFNYILLYVLGLGV 227
Query: 814 LGASLVLSLSWWIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLCLE 993
+G++ ++S +I ++ F+YIV +TW G+S F +F +L+ AS +MLC+E
Sbjct: 228 MGSACANTVSQFIQMILLFLYIVWRRLYADTWGGWSQACFEEWGAFIRLAVASMLMLCIE 287
Query: 994 TWYFQILVLLAGLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAGNPKS 1173
W F+I + LAG+L +LA ++ + I V++I +G A S+RV + LGAGN +
Sbjct: 288 WWAFEISMFLAGVLGMVDLAAQAIIYQVAIV--VYLIPLGLCIAGSIRVGHGLGAGNTEQ 345
Query: 1174 ASFSVIIVNIYSLITCVILAIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLVLNGI 1353
A S ++V + + ++ I++ +DV++Y FT + A VS + P+ + L+ +
Sbjct: 346 AKRSALVVLCMTELCALLSGILLATLKDVVAYIFTSDPNIVALVSYVLPVYSACLLFDAC 405
Query: 1354 QPVLSGVAVGCGWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTLIQTV 1533
G+ G G A + YY+IG+PLG F K G W G++ + Q++
Sbjct: 406 VAACGGILRGSGKLKVGAISHTVGYYVIGLPLGISLMFAAKLGIIGFWFGILACGIAQSI 465
Query: 1534 ILAWVTFRTDWTKEVEEASKR 1596
L F+ DW + EEA R
Sbjct: 466 FLIIFVFKIDWKRASEEAQTR 486
>sp|Q9USK3|YJ2D_SCHPO Uncharacterized transporter C4B3.13 OS=Schizosaccharomyces
pombe GN=SPCC4B3.13 PE=2 SV=1
Length = 539
Score = 235 bits (598), Expect = 1e-060
Identities = 152/483 (31%), Positives = 253/483 (52%), Gaps = 12/483 (2%)
Frame = +1
Query: 181 PSTESSNGELERVLSDVEIPLFHRLR-----KATMIESKLLFKLAAPAVIVYMINYLMSM 345
P+T+ S G LE + I ++ KA E LL K A P V+ ++ Y +
Sbjct: 60 PATDVSYGALEETEENESIASGLSVQEDFNSKAWWKELTLLIKFATPVVLTSLLQYGEVV 119
Query: 346 STQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMGSAVETLCGQAFGGRKYEMLGIYLQ 525
+T GHLG ELAAASL N I A+ + G+ SA++T+ Q+FG YEM+G++LQ
Sbjct: 120 TTVFSLGHLGKTELAAASLSNMTATITAFAIYQGIVSALDTVGTQSFGSGNYEMVGLHLQ 179
Query: 526 RSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASAASIFVYGLIPQIFAYAVNFPIQKF 705
R +L L + LI+ + ILLFL + P A+ ++ ++ AYA+ +++F
Sbjct: 180 RILAILLLIQFPIFLIWWKIEGILLFLRQDPLTCMFAAKYMRVMMLASPAYALFEALKRF 239
Query: 706 LQSQSIVAPSAYISTATLFVHLLLSWLAIYK--LGMGLLGASLVLSLSWWIIVVAQFVYI 879
LQ Q I P YI + +++ L++L ++ +G G LGA + ++L+ W +YI
Sbjct: 240 LQVQGIFHPVTYILAIVVPINIFLNYLFVWSPWVGFGFLGAPVAVALTLWSACAVLIIYI 299
Query: 880 VTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLCLETWYFQILVLLAGLLENPELALD 1059
+ R+ W GFS +A +L+ +M+C E W F+++ +G+L ELA
Sbjct: 300 M-KVNGRQAWGGFSREALKNWGPLCRLAVPGVIMICSEYWAFELVTFASGVLGTTELA-- 356
Query: 1060 SLSICMTISGWVFMISVGFNAAISVRVSNELGAGNPKSASFSV-IIVNIYSLITCVILAI 1236
S+S+ T S + ++ G AA + RV N +GAGN K A + + +N+ + I VI+A+
Sbjct: 357 SMSVLSTTSTLSYNLAFGVAAAAATRVGNLIGAGNTKLAKLATHVSINLGAAIG-VIIAV 415
Query: 1237 VILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLVLNGIQPVLSGVAVGCGWQTFVAKVN 1416
++ R+ +Y FT ++V A V+ + PL+AL + + Q V G+ G G Q VN
Sbjct: 416 ILFLTRNTWTYIFTSDKDVVALVATIIPLVALINIADNTQCVAGGLLRGQGRQRIGGVVN 475
Query: 1417 VGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTLIQTVILAWVTFRTDWTKEVEEASKR 1596
YY++G+P+ + F + G+W G+ LI + W + +W VE A+++
Sbjct: 476 FIAYYLLGLPVAIILCFKLDWGLYGLWIGIGAAILIIAGVETWCSLHVNWDHLVELANRQ 535
Query: 1597 LDK 1605
D+
Sbjct: 536 FDE 538
>sp|Q8K0H1|S47A1_MOUSE Multidrug and toxin extrusion protein 1 OS=Mus musculus
GN=Slc47a1 PE=1 SV=2
Length = 567
Score = 233 bits (594), Expect = 3e-060
Identities = 136/442 (30%), Positives = 237/442 (53%), Gaps = 10/442 (2%)
Frame = +1
Query: 274 ESKLLFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMG 453
E + L LA PA + ++ +L+S + +F GHLG LEL A +L I + + G+
Sbjct: 34 ELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGHGLS 93
Query: 454 SAVETLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASA 633
SA +TL Q +G + + +G+ LQR T++L L +++ ++ ILL + P+++
Sbjct: 94 SACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRL 153
Query: 634 ASIFVYGLIPQIFAYAVNFPIQKFLQSQSIVAPSAYISTATLFVHLLLSWLAIYKLGMGL 813
+V IP + A + K+L +Q IV P A V+ L +++ +Y L +G+
Sbjct: 154 TQTYVMIFIPALPAAFLYTLQVKYLLNQGIVLPQIMTGIAANLVNALANYVFLYHLHLGV 213
Query: 814 LGASLVLSLSWWIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLCLE 993
+G++L ++S + + + F+YI+ + TW G+S + SF +L+ S +MLC+E
Sbjct: 214 MGSALANTISQFALAIFLFLYILWRRLHQATWGGWSWECLQDWASFLRLAIPSMLMLCIE 273
Query: 994 TWYFQILVLLAGLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAGN--- 1164
W +++ L+G+L EL S++ + I V+MI GF+ A +VRV N LGAGN
Sbjct: 274 WWAYEVGSFLSGILGMVELGAQSITYELAII--VYMIPSGFSVAANVRVGNALGAGNIDQ 331
Query: 1165 -PKSASFSVIIVNIYSLITCVILAIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLV 1341
KS++ S+I+ ++++ CV+L L +D++ Y FT ++ A V+ + P+ A++ +
Sbjct: 332 AKKSSAISLIVTELFAVTFCVLL----LGCKDLVGYIFTTDRDIVALVAQVIPIYAVSHL 387
Query: 1342 LNGIQPVLSGVAVGCGWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTL 1521
G+ G+ G G Q A VN YY+IG+P+G F K G+W+G+I T
Sbjct: 388 FEGLACTCGGILRGTGNQKVGAIVNAIGYYVIGLPIGIALMFAAKLGVIGLWSGIIICTT 447
Query: 1522 IQTVILAWVTFRTDWTKEVEEA 1587
QT R +W + ++A
Sbjct: 448 CQTTCFLAFIARLNWKRACQQA 469
>sp|Q5I0E9|S47A1_RAT Multidrug and toxin extrusion protein 1 OS=Rattus
norvegicus GN=Slc47a1 PE=1 SV=1
Length = 566
Score = 228 bits (581), Expect = 1e-058
Identities = 135/442 (30%), Positives = 237/442 (53%), Gaps = 10/442 (2%)
Frame = +1
Query: 274 ESKLLFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMG 453
E + L LA PA + ++ +L+S + +F GHLG LEL A +L I + + G+
Sbjct: 33 ELRALLVLAGPAFLAQLMMFLISFISSVFCGHLGKLELDAVTLAIAVINVTGISVGHGLS 92
Query: 454 SAVETLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASA 633
SA +TL Q +G + + +G+ LQR T++L L +++ ++ ILL + P+++
Sbjct: 93 SACDTLISQTYGSQNLKHVGVILQRGTLILLLCCFPCWALFINTEQILLLFRQDPDVSRL 152
Query: 634 ASIFVYGLIPQIFAYAVNFPIQKFLQSQSIVAPSAYISTATLFVHLLLSWLAIYKLGMGL 813
+V IP + A + K+L +Q IV P A V+ L ++L +++L +G+
Sbjct: 153 TQTYVMVFIPALPAAFLYTLQVKYLLNQGIVLPQVITGIAANLVNALANYLFLHQLHLGV 212
Query: 814 LGASLVLSLSWWIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLCLE 993
+G++L ++S + + + F+YI+ + TW G+S + SF +L+ S +MLC+E
Sbjct: 213 MGSALANTISQFALAIFLFLYILWRKLHHATWGGWSWECLQDWASFLQLAIPSMLMLCIE 272
Query: 994 TWYFQILVLLAGLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAGN--- 1164
W +++ L+G+L EL S++ + I V+MI GF+ A +VRV N LGAGN
Sbjct: 273 WWAYEVGSFLSGILGMVELGAQSITYELAII--VYMIPAGFSVAANVRVGNALGAGNIDQ 330
Query: 1165 -PKSASFSVIIVNIYSLITCVILAIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLV 1341
KS++ S+I+ ++++ CV+L L +D++ Y FT ++ A V+ + P+ A++ +
Sbjct: 331 AKKSSAISLIVTELFAVTFCVLL----LGCKDLVGYIFTTDWDIVALVAQVVPIYAVSHL 386
Query: 1342 LNGIQPVLSGVAVGCGWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTL 1521
+ GV G G Q A VN YY+IG+P+G F K G+W+G+I ++
Sbjct: 387 FEALACTCGGVLRGTGNQKVGAIVNAIGYYVIGLPIGISLMFVAKLGVIGLWSGIIICSV 446
Query: 1522 IQTVILAWVTFRTDWTKEVEEA 1587
QT R +W ++A
Sbjct: 447 CQTSCFLVFIARLNWKLACQQA 468
>sp|Q5RFD2|S47A1_PONAB Multidrug and toxin extrusion protein 1 OS=Pongo abelii
GN=SLC47A1 PE=2 SV=1
Length = 570
Score = 228 bits (579), Expect = 2e-058
Identities = 134/454 (29%), Positives = 238/454 (52%), Gaps = 6/454 (1%)
Frame = +1
Query: 274 ESKLLFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMG 453
E + L LA PA +V ++ +L+S + +F GHLG LEL A +L I + + G+
Sbjct: 34 ELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLS 93
Query: 454 SAVETLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASA 633
SA +TL Q +G + + +G+ LQRS ++L L +++ ++ ILL + P+++
Sbjct: 94 SACDTLISQTYGSQNLKHVGVILQRSALILLLCCFPCWALFLNTQHILLLFRQDPDVSRL 153
Query: 634 ASIFVYGLIPQIFAYAVNFPIQKFLQSQSIVAPSAYISTATLFVHLLLSWLAIYKLGMGL 813
+V IP + A + K+L +Q IV P A V+ L ++L +++L +G
Sbjct: 154 TQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGA 213
Query: 814 LGASLVLSLSWWIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLCLE 993
+G++L +S + + + F YI+ + + TW G+S++ SF L+ S +MLC+E
Sbjct: 214 IGSALANLISQYTLALLLFFYILGKKLHQATWGGWSLECLQDWASFLHLAVPSMLMLCME 273
Query: 994 TWYFQILVLLAGLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAGNPKS 1173
W +++ L+G+L EL S+ + I V+M+ GF+ A SVRV N LGAG+ +
Sbjct: 274 WWAYEVGSFLSGILGMVELGAQSIVYELAII--VYMVPAGFSVAASVRVGNALGAGDMEQ 331
Query: 1174 ASFSVIIVNIYSLITCVILAIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLVLNGI 1353
A S + + +++ V ++++L+ +D + Y FT ++ V+ + P+ A++ + +
Sbjct: 332 ARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEAL 391
Query: 1354 QPVLSGVAVGCGWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTLIQTV 1533
GV G G Q A VN YY++G+P+G F K G+W+G+I T+ Q V
Sbjct: 392 ACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATKLGVMGLWSGIIICTVFQAV 451
Query: 1534 ILAWVTFRTDWTKEVEEASKRLDKWSNKKLEVVP 1635
+ +W K ++A +N K+ VP
Sbjct: 452 CFLGFIIQLNWKKACQQAQVH----ANLKVNNVP 481
>sp|Q3V050|S47A2_MOUSE Multidrug and toxin extrusion protein 2 OS=Mus musculus
GN=Slc47a2 PE=1 SV=1
Length = 573
Score = 228 bits (579), Expect = 2e-058
Identities = 137/455 (30%), Positives = 237/455 (52%), Gaps = 4/455 (0%)
Frame = +1
Query: 274 ESKLLFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMG 453
E+ L LA P + ++ +L+S+ + IF GHLG +EL A +L + + + + G+
Sbjct: 43 EAAALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTGISVGTGLA 102
Query: 454 SAVETLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASA 633
SA +TL Q+FGG+ + +G+ LQR ++L L I++ ++ +LL L + P++A
Sbjct: 103 SACDTLMSQSFGGKNLKRVGVILQRGILILLLCCFPCWAIFLNTERLLLLLRQDPDVARL 162
Query: 634 ASIFVYGLIPQIFAYAVNFPIQ-KFLQSQSIVAPSAYISTATLFVHLLLSWLAIYKLGMG 810
A ++V IP + A A F +Q ++LQSQ I+ P + A V++ ++ +Y L +G
Sbjct: 163 AQVYVMICIPALPA-AFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAFLLYALDLG 221
Query: 811 LLGASLVLSLSWWIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLCL 990
++G++ + S + + F+Y+ TW G++ + F S+ +L+ S M+C+
Sbjct: 222 VVGSAWANTTSQFFLSALLFLYVWWKRIHIHTWGGWTRECFQEWSSYTRLAIPSMFMVCI 281
Query: 991 ETWYFQILVLLAGLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAGNPK 1170
E W F+I LAGL+ EL + ++ ++ +M+ GF A SVRV N LGAGN
Sbjct: 282 EWWTFEIGTFLAGLVNVTELG--AQAVIYELASVAYMVPFGFGVAASVRVGNALGAGNAD 339
Query: 1171 SASFSVIIVNIYSLITCVILAIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLVLNG 1350
A S V + + + +++ I++ A +DV++Y FT +++ + VS + P+ A + +
Sbjct: 340 QARCSCTTVLLCAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMPIFAPFHLFDA 399
Query: 1351 IQPVLSGVAVGCGWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTLIQT 1530
+ GV G G Q A +N YY G P+G F K G+W G+I Q
Sbjct: 400 LAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVSLMFAAKLGIIGLWAGLIVCVSFQA 459
Query: 1531 VILAWVTFRTDWTKEVEEASKRLDKWSNKKLEVVP 1635
RT+W++ E+A R S K+L P
Sbjct: 460 FSYLIYILRTNWSRVAEQAQVRAGLKSTKELIPTP 494
>sp|Q96FL8|S47A1_HUMAN Multidrug and toxin extrusion protein 1 OS=Homo sapiens
GN=SLC47A1 PE=1 SV=1
Length = 570
Score = 227 bits (578), Expect = 2e-058
Identities = 133/454 (29%), Positives = 240/454 (52%), Gaps = 6/454 (1%)
Frame = +1
Query: 274 ESKLLFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMG 453
E + L LA PA +V ++ +L+S + +F GHLG LEL A +L I + + G+
Sbjct: 34 ELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLS 93
Query: 454 SAVETLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASA 633
SA +TL Q +G + + +G+ LQRS ++L L +++ ++ ILL + P+++
Sbjct: 94 SACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRL 153
Query: 634 ASIFVYGLIPQIFAYAVNFPIQKFLQSQSIVAPSAYISTATLFVHLLLSWLAIYKLGMGL 813
+V IP + A + K+L +Q IV P A V+ L ++L +++L +G+
Sbjct: 154 TQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGV 213
Query: 814 LGASLVLSLSWWIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLCLE 993
+G++L +S + + + F+YI+ + + TW G+S++ SF +L+ S +MLC+E
Sbjct: 214 IGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCME 273
Query: 994 TWYFQILVLLAGLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAGNPKS 1173
W +++ L+G+L EL S+ + I V+M+ GF+ A SVRV N LGAG+ +
Sbjct: 274 WWAYEVGSFLSGILGMVELGAQSIVYELAII--VYMVPAGFSVAASVRVGNALGAGDMEQ 331
Query: 1174 ASFSVIIVNIYSLITCVILAIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLVLNGI 1353
A S + + +++ V ++++L+ +D + Y FT ++ V+ + P+ A++ + +
Sbjct: 332 ARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEAL 391
Query: 1354 QPVLSGVAVGCGWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTLIQTV 1533
GV G G Q A VN YY++G+P+G F G+W+G+I T+ Q V
Sbjct: 392 ACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAV 451
Query: 1534 ILAWVTFRTDWTKEVEEASKRLDKWSNKKLEVVP 1635
+ +W K ++A +N K+ VP
Sbjct: 452 CFLGFIIQLNWKKACQQAQVH----ANLKVNNVP 481
>sp|A1L1P9|S47A1_DANRE Multidrug and toxin extrusion protein 1 OS=Danio rerio
GN=slc47a1 PE=2 SV=1
Length = 590
Score = 222 bits (564), Expect = 1e-056
Identities = 129/435 (29%), Positives = 225/435 (51%), Gaps = 4/435 (0%)
Frame = +1
Query: 286 LFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMGSAVE 465
L KLA P I ++ +L+S + +F GHLG ELA +L I + + G+ SA +
Sbjct: 56 LLKLAGPVFISQLMIFLISFVSTVFCGHLGKTELAGVALAIAVINVTGISIGSGLASACD 115
Query: 466 TLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASAASIF 645
TL Q FG + +G+ LQR ++L L + + ++PILL + +SP +AS + ++
Sbjct: 116 TLISQTFGSNNLKRVGVILQRGILILLLACFPCWALLINTEPILLAVRQSPNVASLSQLY 175
Query: 646 VYGLIPQIFAYAVNFPIQ-KFLQSQSIVAPSAYISTATLFVHLLLSWLAIYKLGMGLLGA 822
V +P + A A + +Q ++LQ+Q I+ P A ++ L++++ ++ L +G+ G+
Sbjct: 176 VKIFMPALPA-AFMYQLQGRYLQNQGIIWPQVITGAAGNILNALINYVFLHLLELGVAGS 234
Query: 823 SLVLSLSWWIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLCLETWY 1002
+ ++S + + V +VYI + TW G+S +F +L+ S +MLC+E W
Sbjct: 235 AAANTISQYSLAVFLYVYIRWKNLHKATWDGWSRDCLQEWGAFIRLALPSMLMLCVEWWT 294
Query: 1003 FQILVLLAGLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAGNPKSASF 1182
++I LAGL+ EL + S+ ++ +M +GF A SVRV N LGAGN + A
Sbjct: 295 YEIGGFLAGLISETELG--AQSVVYELATIAYMFPLGFAVAASVRVGNALGAGNTERAKL 352
Query: 1183 SVIIVNIYSLITCVILAIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLVLNGIQPV 1362
S + + ++ ++A +I +DV++Y FT EE+ + VS + + + + I +
Sbjct: 353 SAKVALVCGVLVSCVVATLIGCTKDVIAYIFTTEEEIVSRVSQVMIMYGFFHLFDAIAGI 412
Query: 1363 LSGVAVGCGWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTLIQTVILA 1542
G+ G G Q A N+ YY +G P G F G+W G +Q++
Sbjct: 413 TGGIVRGAGKQLLGALCNIVGYYFVGFPTGVSLMFALSMGIIGLWIGFFGCVFLQSLFFI 472
Query: 1543 WVTFRTDWTKEVEEA 1587
+ ++ DW K +EA
Sbjct: 473 ILIYKLDWKKATQEA 487
>sp|Q9UT92|YL47_SCHPO Uncharacterized transporter C323.07c
OS=Schizosaccharomyces pombe GN=SPAC323.07c PE=1 SV=1
Length = 533
Score = 213 bits (541), Expect = 4e-054
Identities = 141/442 (31%), Positives = 221/442 (50%), Gaps = 9/442 (2%)
Frame = +1
Query: 286 LFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMGSAVE 465
L +L +P VI Y++ ST GHLG LAA+SL I A+ + G+ S+++
Sbjct: 94 LLRLGSPTVIAYLLQSSEQFSTVFTLGHLGKEYLAASSLSTMTAAISAFSIFQGVISSLD 153
Query: 466 TLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASAASIF 645
TL QAFG K + IYLQR ++L++ + + LI++ + IL+FL + P +A +
Sbjct: 154 TLATQAFGANKPYNVAIYLQRCLLILAVLHIPVALIWLNLEHILIFLHQDPMVAHLCGRY 213
Query: 646 VYGLIPQIFAYAVNFPIQKFLQSQSIVAPSAYISTATLFVHLLLSWLAIY--KLGMGLLG 819
+ I YAV ++++LQ+Q I P Y+ +++LL++L ++ +G G LG
Sbjct: 214 MRVFILAAPGYAVFEALKRYLQAQGIFTPITYVLCFAAPLNILLNYLLVWHPTIGFGFLG 273
Query: 820 ASLVLSLSWWIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLCLETW 999
A + ++ ++W + +YI S W GFS QA L S +M+ E
Sbjct: 274 APVAVATTFWFQSICLILYICFSS-TPIPWPGFSRQALKNLSPMLHFSFHGMLMIVTEWA 332
Query: 1000 YFQILVLLAGLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAGNPKSAS 1179
+++ L AG L LA S SI +T + +F I F A S RV + +G+G A
Sbjct: 333 AYEMTSLGAGYLGTAPLA--SQSILLTSTSLLFQIPFAFAVASSTRVGHLIGSGRANLAR 390
Query: 1180 FSVIIVNIYSLITCVIL--AIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLVLNGI 1353
+ YSL C+ + +I FRDV FT EV A V D+ P+L+L +V +G+
Sbjct: 391 LCSRVA--YSLALCISIFDGSLIFCFRDVWGSLFTSDPEVLAVVKDIFPILSLFIVTDGL 448
Query: 1354 QPVLSGVAVGCGWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTLIQTV 1533
V G+ G G Q +++G Y+ +P+ YF KGIW GMI ++
Sbjct: 449 NAVGGGLLRGTGKQYIGGLISIGSSYLFALPVTVFVVVYFNTGLKGIWCGMILSSVTAIT 508
Query: 1534 ILAWVTFRTDWTKEVEEASKRL 1599
V F TDW + ++EA RL
Sbjct: 509 CQFTVLFNTDWHRVLQEARHRL 530
>sp|A7KAU3|S47A2_RABIT Multidrug and toxin extrusion protein 2 OS=Oryctolagus
cuniculus GN=SLC47A2 PE=1 SV=1
Length = 601
Score = 209 bits (531), Expect = 6e-053
Identities = 132/444 (29%), Positives = 225/444 (50%), Gaps = 10/444 (2%)
Frame = +1
Query: 274 ESKLLFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMG 453
E++ LF L+ P + ++N+L + +F GHLG +ELA+ +LG + + + G+
Sbjct: 59 EARALFVLSGPLFLFQVLNFLTYVVGTVFCGHLGKVELASVTLGVAFVNVCGVSVGAGLS 118
Query: 454 SAVETLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIA-- 627
SA +TL Q+FG + +G+ LQR +++L L + +++ ++ ILL + P ++
Sbjct: 119 SACDTLMSQSFGSPNKKHVGVILQRGSLILLLCCLPCWALFLNTQHILLLFRQDPAVSRL 178
Query: 628 --SAASIFVYGLIPQIFAYAVNFPIQKFLQSQSIVAPSAYISTATLFVHLLLSWLAIYKL 801
A IF+ GL P IF Y++ + K+LQ+Q IV P V+ + ++ + L
Sbjct: 179 TQDYAMIFIPGL-PAIFLYSL---LAKYLQNQGIVWPQVLSGVVGNCVNGVANYALVSVL 234
Query: 802 GMGLLGASLVLSLSWWIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVM 981
+G+ G++ ++S ++ F++IV + ETW G+S Q F L+ S +M
Sbjct: 235 NLGVRGSAYANTISQFVQAAFLFLHIVLKKLHLETWEGWSSQCLRDWGPFLSLAIPSMLM 294
Query: 982 LCLETWYFQILVLLAGLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAG 1161
+C+E W ++I L GLL +L+ +I ++ V+MI +G A+ VRV LGA
Sbjct: 295 MCVEWWAYEIGSFLMGLLGVVDLS--GQAIIYEVATVVYMIPMGLGMAVCVRVGTALGAA 352
Query: 1162 NPKSASFSVIIVNIYSLITCVILAIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLV 1341
+ A S + + + T +++ ++ L Y FT EEV A V+ + P+ + +
Sbjct: 353 DTLQAKRSAVSGLLCTAGTSLVVGTLLGLLNSQLGYIFTSDEEVIALVNQVLPIYIVFQL 412
Query: 1342 LNGIQPVLSGVAVGCGWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTL 1521
+ + V GV G G Q F A VN YYI+G+PLG + F G+W GM+
Sbjct: 413 VEAVCCVFGGVLRGTGKQAFGAIVNAIMYYIVGLPLGIVLTFVVGMRIMGLWLGMLTCIF 472
Query: 1522 IQTVILAWVTFRTDWTKEVEEASK 1593
+ V + DW EEA K
Sbjct: 473 LAAVTFVVYAVQLDWKLAAEEAQK 496
>sp|Q10085|YAO6_SCHPO Uncharacterized transporter C11D3.06
OS=Schizosaccharomyces pombe GN=SPAC11D3.06 PE=2 SV=1
Length = 455
Score = 208 bits (528), Expect = 1e-052
Identities = 136/445 (30%), Positives = 224/445 (50%), Gaps = 8/445 (1%)
Frame = +1
Query: 268 MIESKLLFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLG 447
+ E K L +AP ++ Y + + S+ I +G LG EL+ A+ + + LG
Sbjct: 5 LTEVKYLLINSAPVILGYALQNSLQTSSVIVTGRLGPSELSVAAFAYMFAMSTGWLIALG 64
Query: 448 MGSAVETLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIA 627
+A +TL +G K + LGI LQ ++LS+ + + L++ +SKPIL+FL ++PE+A
Sbjct: 65 GTTAFDTLGSNLWGAGKKQELGILLQTGFIVLSILYLPICLVWWYSKPILIFLHQTPELA 124
Query: 628 SAASIFVYGLIPQIFAYAVNFPIQKFLQSQSIVAPSAYISTATLFVHLLLSWLAIYKLGM 807
A+ F+ LIP Y ++KFLQ+Q I +YI T +++ L++L ++ G+
Sbjct: 125 EASQKFLRYLIPGGLGYVCFELLKKFLQTQEITRAGSYILLVTSPLNVALNFLLVHYYGL 184
Query: 808 GLLGASLVLSLSWWI--IVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVM 981
GL GA L LS+W+ I++ Q+ V + E W G++ + F KLS VM
Sbjct: 185 GLKGAPLATGLSYWLSFILLTQYAKYV---KGAEAWNGWNKRCLENFGPFVKLSLLGIVM 241
Query: 982 LCLETWYFQILVLLAGLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAG 1161
+ E W F+I+ L+AG L LA + S+ MT + I G S RV+ LGAG
Sbjct: 242 VGTEWWAFEIVALVAGKLGAVPLA--AQSVIMTTDQLLNTIPFGLGIITSNRVAYYLGAG 299
Query: 1162 NPKSASFSVIIVNIYSLITCVILAIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLV 1341
P +AS + + I + ++ I ++A R++ FT +V V+ + PL+A +
Sbjct: 300 LPDNASLTAKVAAIVGVAVGSVIMITMIAVRNIYGRIFTNDPDVIQLVALVMPLVAAFQI 359
Query: 1342 LNGIQPVLSGVAVGCGWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTL 1521
+ + + G G G Q A VN+ YY+ +PLG F+ K G+W G +
Sbjct: 360 SDSLNGTMGGALRGTGRQKVGAIVNITAYYLFALPLGIYLAFHGK-GLVGLWIGQVIALS 418
Query: 1522 IQTVILAWVTFRTDWTKEVEEASKR 1596
I ++ + TDW + +A R
Sbjct: 419 IVGILELKIVMATDWISQSRKAISR 443
>sp|Q05497|YD338_YEAST Uncharacterized transporter YDR338C OS=Saccharomyces
cerevisiae GN=YDR338C PE=1 SV=1
Length = 695
Score = 170 bits (429), Expect = 4e-041
Identities = 107/435 (24%), Positives = 218/435 (50%), Gaps = 6/435 (1%)
Frame = +1
Query: 274 ESKLLFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMG 453
E+++L + P + +++ + M + GHLG ELAA SL + I + G+
Sbjct: 228 EARVLASYSFPLIFTFLLEQIFPMVCSLTVGHLGKNELAAVSLASMTSNI-TLAIFEGIA 286
Query: 454 SAVETLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASA 633
++++TLC QA+G ++ +G++LQR + + +++ +S+P+L ++ E+ +
Sbjct: 287 TSLDTLCPQAYGSGRFYSVGVHLQRCIAFSLVIYIPFAVMWWYSEPLLSYIIPEKELINL 346
Query: 634 ASIFVYGLIPQIFAYAVNFPIQKFLQSQSIVAPSAYISTATLFVHLLLSWLAIYK--LGM 807
S F+ LI AY +++FLQ+Q I Y+ T +++L+S+ ++ +G+
Sbjct: 347 TSRFLRVLILGAPAYIFFENLKRFLQAQGIFDAGIYVLTICAPLNVLVSYTLVWNKYIGV 406
Query: 808 GLLGASLVLSLSWWIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLC 987
G +GA++ + L++W++ Y + + R+ W GFS +AF+ L+ + +ML
Sbjct: 407 GFIGAAIAVVLNFWLMFFLLLFYALYIDG-RKCWGGFSRKAFTHWNDLGHLAFSGIIMLE 465
Query: 988 LETWYFQILVLLAGLLENPELALDSLSICMTISGWVFMISVGFNAAISVRVSNELGAGNP 1167
E +++L L + LA + S T++ ++MI + S R++N +GA
Sbjct: 466 AEELSYELLTLFSAYYGVSYLA--AQSAVSTMAALLYMIPFAIGISTSTRIANFIGAKRT 523
Query: 1168 KSASFSVIIVNIYSLITCVILAIVILAFRDVLSYAFTEGEEVSAAVSDLCPLLALTLVLN 1347
A S + +S I I +++ R++++ +++ EV ++ + PL+ + +
Sbjct: 524 DFAHISSQVGLSFSFIAGFINCCILVFGRNLIANIYSKDPEVIKLIAQVLPLVGIVQNFD 583
Query: 1348 GIQPVLSGVAVGCGWQTFVAKVNVGCYYIIGIPLGALFGFYFKFDAKGIWTGMICGTLIQ 1527
+ V G G Q+ + VN+ YY+ GIPL + ++F G+W G+ L+
Sbjct: 584 SLNAVAGSCLRGQGMQSLGSIVNLMAYYLFGIPLALILSWFFDMKLYGLWIGIGSAMLLI 643
Query: 1528 TVILAWVTFRTDWTK 1572
++ A+ DW K
Sbjct: 644 GLVEAYYVLFPDWDK 658
>sp|Q86VL8|S47A2_HUMAN Multidrug and toxin extrusion protein 2 OS=Homo sapiens
GN=SLC47A2 PE=1 SV=1
Length = 602
Score = 141 bits (353), Expect = 3e-032
Identities = 90/304 (29%), Positives = 144/304 (47%), Gaps = 2/304 (0%)
Frame = +1
Query: 715 QSIVAPSAYISTATLFVHLLLSWLAIYKLGMGLLGASLVLSLSWWIIVVAQFVYIVTSER 894
Q I P V+ + ++ + L +G+ G++ +S + V +YIV +
Sbjct: 213 QKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKL 272
Query: 895 CRETWRGFSVQAFSGLPSFFKLSAASAVMLCLETWYFQILVLLAGLLENPELALDSLSIC 1074
ETW G+S Q FF L+ S +M+C+E W ++I L GLL +L+ + ++
Sbjct: 273 HLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLS--AQAVI 330
Query: 1075 MTISGWVFMISVGFNAAISVRVSNELGAGNPKSASFSVIIVNIYSLITCVILAIVILAFR 1254
++ +MI +G + + VRV LGA + A S + + + ++L +I +
Sbjct: 331 YEVATVTYMIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILK 390
Query: 1255 DVLSYAFTEGEEVSAAVSDLCPLLALTLVLNGIQPVLSGVAVGCGWQTFVAKVNVGCYYI 1434
+ L + FT E+V A VS + P+ ++ V I V GV G G Q F A VN YYI
Sbjct: 391 NQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYI 450
Query: 1435 IGIPLGALFGFYFKFDAKGIWTGMICGTLIQTVILAWVTFRTDWTKEVEEASKRLDKWSN 1614
IG+PLG L F + G+W GM+ + T T R DW EEA K +
Sbjct: 451 IGLPLGILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWKLAAEEAKKHSGRQQQ 510
Query: 1615 KKLE 1626
++ E
Sbjct: 511 QRAE 514
Score = 74 bits (181), Expect = 2e-012
Identities = 43/148 (29%), Positives = 83/148 (56%), Gaps = 8/148 (5%)
Frame = +1
Query: 286 LFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMGSAVE 465
LF L+ P + ++ +++ + + +F GHLG +ELA+ +L + + + +G+ SA +
Sbjct: 34 LFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACD 93
Query: 466 TLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASAAS-- 639
TL Q+FG + +G+ LQR ++L L + +++ ++ ILL + P+++
Sbjct: 94 TLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDY 153
Query: 640 --IFVYGLIPQIFAYAVNFPIQKFLQSQ 717
IF+ GL P IF Y + + K+LQ+Q
Sbjct: 154 VMIFIPGL-PVIFLYNL---LAKYLQNQ 177
>sp|Q5R7E4|S47A2_PONAB Multidrug and toxin extrusion protein 2 OS=Pongo abelii
GN=SLC47A2 PE=2 SV=1
Length = 581
Score = 122 bits (306), Expect = 8e-027
Identities = 75/264 (28%), Positives = 138/264 (52%), Gaps = 8/264 (3%)
Frame = +1
Query: 286 LFKLAAPAVIVYMINYLMSMSTQIFSGHLGNLELAAASLGNTGIQIFAYGLMLGMGSAVE 465
LF L+ P + ++ +++ + + +F GHLG +ELA+ +L + + + +G+ SA +
Sbjct: 34 LFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSSACD 93
Query: 466 TLCGQAFGGRKYEMLGIYLQRSTVLLSLTGVLLTLIYVFSKPILLFLGESPEIASAAS-- 639
TL Q+FG + +G+ LQR ++L L + +++ ++ ILL + PE++
Sbjct: 94 TLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPEVSRLTQDY 153
Query: 640 --IFVYGLIPQIFAYAVNFPIQKFLQSQSIVAPSAYISTATLFVHLLLSWLAIYKLGMGL 813
IF+ GL P IF Y + + K+LQ+Q I P V+ + ++ + L +G+
Sbjct: 154 VMIFIPGL-PVIFLYNL---LAKYLQNQKITWPQVLSGVVGNCVNGVANYALVSVLNLGV 209
Query: 814 LGASLVLSLSWWIIVVAQFVYIVTSERCRETWRGFSVQAFSGLPSFFKLSAASAVMLCLE 993
G++ +S + V +YIV + ETW G+S Q FF L+ S +M+C+E
Sbjct: 210 RGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVE 269
Query: 994 TWYFQILVLLAGLLENPELALDSL 1065
W ++I L GLL +L+ ++
Sbjct: 270 WWAYEIGSFLMGLLSVVDLSAQAV 293
Score = 93 bits (230), Expect = 5e-018
Identities = 57/167 (34%), Positives = 80/167 (47%)
Frame = +1
Query: 1093 VFMISVGFNAAISVRVSNELGAGNPKSASFSVIIVNIYSLITCVILAIVILAFRDVLSYA 1272
V I +G + + VRV LGA + A S + + + ++L +I ++ L +
Sbjct: 315 VARIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHI 374
Query: 1273 FTEGEEVSAAVSDLCPLLALTLVLNGIQPVLSGVAVGCGWQTFVAKVNVGCYYIIGIPLG 1452
FT E+V A VS + P+ ++ V I V GV G G Q F A VN YYIIG+PLG
Sbjct: 375 FTNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLG 434
Query: 1453 ALFGFYFKFDAKGIWTGMICGTLIQTVILAWVTFRTDWTKEVEEASK 1593
L F + G+W GM+ + T T R DW EEA K
Sbjct: 435 ILLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWKLAAEEAKK 481
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,959,508,338
Number of Sequences: 518415
Number of Extensions: 83959508338
Number of Successful Extensions: 579439005
Number of sequences better than 0.0: 0
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