BLASTX 7.6.2
Query= UN20533 /QuerySize=1166
(1165 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q10576|P4HA1_CAEEL Prolyl 4-hydroxylase subunit alpha-1 OS=Ca... 122 6e-027
sp|Q20065|P4HA2_CAEEL Prolyl 4-hydroxylase subunit alpha-2 OS=Ca... 117 1e-025
sp|Q5ZLK5|P4HA2_CHICK Prolyl 4-hydroxylase subunit alpha-2 OS=Ga... 91 2e-017
sp|Q60716|P4HA2_MOUSE Prolyl 4-hydroxylase subunit alpha-2 OS=Mu... 88 1e-016
sp|P54001|P4HA1_RAT Prolyl 4-hydroxylase subunit alpha-1 OS=Ratt... 87 2e-016
sp|O15460|P4HA2_HUMAN Prolyl 4-hydroxylase subunit alpha-2 OS=Ho... 87 2e-016
sp|P16924|P4HA1_CHICK Prolyl 4-hydroxylase subunit alpha-1 OS=Ga... 86 5e-016
sp|Q60715|P4HA1_MOUSE Prolyl 4-hydroxylase subunit alpha-1 OS=Mu... 80 2e-014
sp|P13674|P4HA1_HUMAN Prolyl 4-hydroxylase subunit alpha-1 OS=Ho... 80 3e-014
sp|Q5RAG8|P4HA1_PONAB Prolyl 4-hydroxylase subunit alpha-1 OS=Po... 80 3e-014
sp|Q1RMU3|P4HA1_BOVIN Prolyl 4-hydroxylase subunit alpha-1 OS=Bo... 79 7e-014
sp|Q19673|TYR3_CAEEL Putative tyrosinase-like protein tyr-3 OS=C... 53 3e-006
>sp|Q10576|P4HA1_CAEEL Prolyl 4-hydroxylase subunit alpha-1 OS=Caenorhabditis
elegans GN=dpy-18 PE=1 SV=2
Length = 559
Score = 122 bits (305), Expect = 6e-027
Identities = 77/225 (34%), Positives = 113/225 (50%), Gaps = 24/225 (10%)
Frame = +1
Query: 196 LVIDPSRVTQLSWTPRVFLYKGLLTDEECDHFINLAKGKLEKSMVADNDSGESVESEVRT 375
LV P +V + P L+K +++D+E LAK KL ++ V D+ +G+ V + R
Sbjct: 314 LVYAPIKVEIKRFNPLAVLFKDVISDDEVAAIQELAKPKLARATVHDSVTGKLVTATYRI 373
Query: 376 SSGMFLSKRQDDVVANVEAKLAAWTFLPEENGESMQILHYENGQKYEPHFDYFHDQVNL- 552
S +L + + DVV V ++ T L E E +QI +Y G Y+PHFD+ + +
Sbjct: 374 SKSAWLKEWEGDVVETVNKRIGYMTNLEMETAEELQIANYGIGGHYDPHFDHAKKEESKS 433
Query: 553 --QLG-GHRIATVLMYLSNVEKGGETVFPMWKGATAQPKDDSWTQCAKQGYAVKPRKGDA 723
LG G+RIATVL Y+S GG TVF K + P K DA
Sbjct: 434 FESLGTGNRIATVLFYMSQPSHGGGTVFTEAKS------------------TILPTKNDA 475
Query: 724 LLFFNLHPNATTDPSSLHGSCPVVEGEKWSATRWIHVK--SFERP 852
L ++NL+ +P + H +CPV+ G KW + +WIH K F RP
Sbjct: 476 LFWYNLYKQGDGNPDTRHAACPVLVGIKWVSNKWIHEKGNEFRRP 520
>sp|Q20065|P4HA2_CAEEL Prolyl 4-hydroxylase subunit alpha-2 OS=Caenorhabditis
elegans GN=phy-2 PE=1 SV=1
Length = 539
Score = 117 bits (293), Expect = 1e-025
Identities = 77/246 (31%), Positives = 116/246 (47%), Gaps = 28/246 (11%)
Frame = +1
Query: 133 PRWSSNNREGSVIKQKTSGSSLVIDPSRVTQLSWTPRVFLYKGLLTDEECDHFINLAKGK 312
P+W + R K L + P +V L + P L+K ++ D E + LA K
Sbjct: 294 PKWKNKLR----CYLKRDKPFLKLAPIKVEILRFDPLAVLFKNVIHDSEIEVIKELASPK 349
Query: 313 LEKSMVADNDSGESVESEVRTSSGMFLSKRQDDVVANVEAKLAAWTFLPEENGESMQILH 492
L+++ V ++ +GE + R S +L D V+ V ++ +T L + E +Q+ +
Sbjct: 350 LKRATVQNSKTGELEHATYRISKSAWLKGDLDPVIDRVNRRIEDFTNLNQATSEELQVAN 409
Query: 493 YENGQKYEPHFDYFHDQVNLQL----GGHRIATVLMYLSNVEKGGETVFPMWKGATAQPK 660
Y G Y+PHFD+ + G+RIATVL Y+S E+GG TVF
Sbjct: 410 YGLGGHYDPHFDFARKEEKNAFKTLNTGNRIATVLFYMSQPERGGATVF----------- 458
Query: 661 DDSWTQCAKQGYAVKPRKGDALLFFNLHPNATTDPSSLHGSCPVVEGEKWSATRWIHVK- 837
G AV P K DAL ++NL + D + H +CPV+ G KW + +WIH K
Sbjct: 459 -------NHLGTAVFPSKNDALFWYNLRRDGEGDLRTRHAACPVLLGVKWVSNKWIHEKG 511
Query: 838 -SFERP 852
F RP
Sbjct: 512 QEFTRP 517
>sp|Q5ZLK5|P4HA2_CHICK Prolyl 4-hydroxylase subunit alpha-2 OS=Gallus gallus
GN=P4HA2 PE=2 SV=1
Length = 534
Score = 91 bits (223), Expect = 2e-017
Identities = 56/157 (35%), Positives = 85/157 (54%), Gaps = 3/157 (1%)
Frame = +1
Query: 196 LVIDPSRVTQLSWTPRVFLYKGLLTDEECDHFINLAKGKLEKSMVADNDSGESVESEVRT 375
L+I P + +P + Y +++DEE + LAK KL ++ V D +G + R
Sbjct: 323 LLIAPFKEEDEWDSPHIVRYYDVMSDEEIEKIKQLAKPKLARATVRDPKTGVLTVASYRV 382
Query: 376 SSGMFLSKRQDDVVANVEAKLAAWTFLPEENGESMQILHYENGQKYEPHFDYFHDQVN-- 549
S +L + D VVA V ++ T L + E +Q+ +Y G +YEPHFD+ +
Sbjct: 383 SKSSWLEEDDDPVVAKVNQRMQQITGLTVKTAELLQVANYGMGGQYEPHFDFSRRPFDST 442
Query: 550 LQLGGHRIATVLMYLSNVEKGGETVFPMWKGATAQPK 660
L+ G+R+AT L Y+S+VE GG TVFP + GA PK
Sbjct: 443 LKSEGNRLATFLNYMSDVEAGGATVFPDF-GAAIWPK 478
>sp|Q60716|P4HA2_MOUSE Prolyl 4-hydroxylase subunit alpha-2 OS=Mus musculus
GN=P4ha2 PE=2 SV=1
Length = 537
Score = 88 bits (216), Expect = 1e-016
Identities = 56/159 (35%), Positives = 85/159 (53%), Gaps = 5/159 (3%)
Frame = +1
Query: 196 LVIDPSRVTQLSWTPRVFLYKGLLTDEECDHFINLAKGKLEKSMVADNDSGESVESEVRT 375
L+I P + +P + Y +++DEE + +AK KL ++ V D +G + R
Sbjct: 324 LLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRV 383
Query: 376 SSGMFLSKRQDDVVANVEAKLAAWTFLPEENGESMQILHYENGQKYEPHFDYFH---DQV 546
S +L + D VVA V ++ T L + E +Q+ +Y G +YEPHFD+ +
Sbjct: 384 SKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRSDDEDA 443
Query: 547 NLQLG-GHRIATVLMYLSNVEKGGETVFPMWKGATAQPK 660
+LG G+R+AT L Y+S+VE GG TVFP GA PK
Sbjct: 444 FKRLGTGNRVATFLNYMSDVEAGGATVFPD-LGAAIWPK 481
>sp|P54001|P4HA1_RAT Prolyl 4-hydroxylase subunit alpha-1 OS=Rattus norvegicus
GN=P4ha1 PE=2 SV=2
Length = 534
Score = 87 bits (215), Expect = 2e-016
Identities = 52/145 (35%), Positives = 85/145 (58%), Gaps = 5/145 (3%)
Frame = +1
Query: 238 PRVFLYKGLLTDEECDHFINLAKGKLEKSMVADNDSGESVESEVRTSSGMFLSKRQDDVV 417
PR+ + +++D E + +LAK +L ++ V D ++G+ ++ R S +LS +D VV
Sbjct: 335 PRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYEDPVV 394
Query: 418 ANVEAKLAAWTFLPEENGESMQILHYENGQKYEPHFDYFH-DQVNL--QLG-GHRIATVL 585
+ + ++ T L E +Q+ +Y G +YEPHFD+ D+ + +LG G+RIAT L
Sbjct: 395 SRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWL 454
Query: 586 MYLSNVEKGGETVFPMWKGATAQPK 660
Y+S+V GG TVFP GA+ PK
Sbjct: 455 FYMSDVSAGGATVFPE-VGASVWPK 478
>sp|O15460|P4HA2_HUMAN Prolyl 4-hydroxylase subunit alpha-2 OS=Homo sapiens
GN=P4HA2 PE=1 SV=1
Length = 535
Score = 87 bits (214), Expect = 2e-016
Identities = 56/159 (35%), Positives = 84/159 (52%), Gaps = 5/159 (3%)
Frame = +1
Query: 196 LVIDPSRVTQLSWTPRVFLYKGLLTDEECDHFINLAKGKLEKSMVADNDSGESVESEVRT 375
L+I P + +P + Y +++DEE + +AK KL ++ V D +G + R
Sbjct: 322 LLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRV 381
Query: 376 SSGMFLSKRQDDVVANVEAKLAAWTFLPEENGESMQILHYENGQKYEPHFDYFHDQVN-- 549
S +L + D VVA V ++ T L + E +Q+ +Y G +YEPHFD+ +
Sbjct: 382 SKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDT 441
Query: 550 -LQLG-GHRIATVLMYLSNVEKGGETVFPMWKGATAQPK 660
LG G+R+AT L Y+S+VE GG TVFP GA PK
Sbjct: 442 FKHLGTGNRVATFLNYMSDVEAGGATVFPD-LGAAIWPK 479
>sp|P16924|P4HA1_CHICK Prolyl 4-hydroxylase subunit alpha-1 OS=Gallus gallus
GN=P4HA1 PE=1 SV=1
Length = 516
Score = 86 bits (211), Expect = 5e-016
Identities = 52/145 (35%), Positives = 83/145 (57%), Gaps = 5/145 (3%)
Frame = +1
Query: 238 PRVFLYKGLLTDEECDHFINLAKGKLEKSMVADNDSGESVESEVRTSSGMFLSKRQDDVV 417
PR+ + +++DEE + LAK +L ++ V D ++G+ + R S +LS + VV
Sbjct: 317 PRIVRFLDIISDEEIETVKELAKPRLSRATVHDPETGKLTTAHYRVSKSAWLSGYESPVV 376
Query: 418 ANVEAKLAAWTFLPEENGESMQILHYENGQKYEPHFDYFH-DQVNL--QLG-GHRIATVL 585
+ + ++ T L E +Q+ +Y G +YEPHFD+ D+ + +LG G+RIAT L
Sbjct: 377 SRINTRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFGRKDEPDAFKELGTGNRIATWL 436
Query: 586 MYLSNVEKGGETVFPMWKGATAQPK 660
Y+S+V GG TVFP GA+ PK
Sbjct: 437 FYMSDVSAGGATVFPE-VGASVWPK 460
>sp|Q60715|P4HA1_MOUSE Prolyl 4-hydroxylase subunit alpha-1 OS=Mus musculus
GN=P4ha1 PE=2 SV=2
Length = 534
Score = 80 bits (197), Expect = 2e-014
Identities = 50/145 (34%), Positives = 82/145 (56%), Gaps = 5/145 (3%)
Frame = +1
Query: 238 PRVFLYKGLLTDEECDHFINLAKGKLEKSMVADNDSGESVESEVRTSSGMFLSKRQDDVV 417
PR+ + +++D E + +LAK +L ++ +++ +G R S +LS +D VV
Sbjct: 335 PRIIRFHDIISDAEIEIVKDLAKPRLRRATISNPVTGALETVHYRISKSAWLSGYEDPVV 394
Query: 418 ANVEAKLAAWTFLPEENGESMQILHYENGQKYEPHFDYFH-DQVNL--QLG-GHRIATVL 585
+ + ++ T L E +Q+ +Y G +YEPHFD+ D+ + +LG G+RIAT L
Sbjct: 395 SRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWL 454
Query: 586 MYLSNVEKGGETVFPMWKGATAQPK 660
Y+S+V GG TVFP GA+ PK
Sbjct: 455 FYMSDVSAGGATVFPE-VGASVWPK 478
>sp|P13674|P4HA1_HUMAN Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens
GN=P4HA1 PE=1 SV=2
Length = 534
Score = 80 bits (195), Expect = 3e-014
Identities = 49/145 (33%), Positives = 83/145 (57%), Gaps = 5/145 (3%)
Frame = +1
Query: 238 PRVFLYKGLLTDEECDHFINLAKGKLEKSMVADNDSGESVESEVRTSSGMFLSKRQDDVV 417
PR+ + +++D E + +LAK +L ++ +++ +G+ R S +LS ++ VV
Sbjct: 335 PRIIRFHDIISDAEIEIVKDLAKPRLRRATISNPITGDLETVHYRISKSAWLSGYENPVV 394
Query: 418 ANVEAKLAAWTFLPEENGESMQILHYENGQKYEPHFDYFH-DQVNL--QLG-GHRIATVL 585
+ + ++ T L E +Q+ +Y G +YEPHFD+ D+ + +LG G+RIAT L
Sbjct: 395 SRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWL 454
Query: 586 MYLSNVEKGGETVFPMWKGATAQPK 660
Y+S+V GG TVFP GA+ PK
Sbjct: 455 FYMSDVSAGGATVFPE-VGASVWPK 478
>sp|Q5RAG8|P4HA1_PONAB Prolyl 4-hydroxylase subunit alpha-1 OS=Pongo abelii
GN=P4HA1 PE=2 SV=1
Length = 534
Score = 80 bits (195), Expect = 3e-014
Identities = 49/145 (33%), Positives = 83/145 (57%), Gaps = 5/145 (3%)
Frame = +1
Query: 238 PRVFLYKGLLTDEECDHFINLAKGKLEKSMVADNDSGESVESEVRTSSGMFLSKRQDDVV 417
PR+ + +++D E + +LAK +L ++ +++ +G+ R S +LS ++ VV
Sbjct: 335 PRIIRFHDIISDAEIEIVKDLAKPRLRRATISNPITGDLETVHYRISKSAWLSGYENPVV 394
Query: 418 ANVEAKLAAWTFLPEENGESMQILHYENGQKYEPHFDYFH-DQVNL--QLG-GHRIATVL 585
+ + ++ T L E +Q+ +Y G +YEPHFD+ D+ + +LG G+RIAT L
Sbjct: 395 SRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWL 454
Query: 586 MYLSNVEKGGETVFPMWKGATAQPK 660
Y+S+V GG TVFP GA+ PK
Sbjct: 455 FYMSDVSAGGATVFPE-VGASVWPK 478
>sp|Q1RMU3|P4HA1_BOVIN Prolyl 4-hydroxylase subunit alpha-1 OS=Bos taurus
GN=P4HA1 PE=1 SV=1
Length = 534
Score = 79 bits (192), Expect = 7e-014
Identities = 49/145 (33%), Positives = 83/145 (57%), Gaps = 5/145 (3%)
Frame = +1
Query: 238 PRVFLYKGLLTDEECDHFINLAKGKLEKSMVADNDSGESVESEVRTSSGMFLSKRQDDVV 417
PR+ + +++D E + +LAK +L ++ +++ +G+ R S +LS ++ VV
Sbjct: 335 PRIIRFHDIISDAEIEVVKDLAKPRLRRATISNPITGDLETVHYRISKSAWLSGYENPVV 394
Query: 418 ANVEAKLAAWTFLPEENGESMQILHYENGQKYEPHFDYFH-DQVNL--QLG-GHRIATVL 585
+ + ++ T L E +Q+ +Y G +YEPHFD+ D+ + +LG G+RIAT L
Sbjct: 395 SRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGTGNRIATWL 454
Query: 586 MYLSNVEKGGETVFPMWKGATAQPK 660
Y+S+V GG TVFP GA+ PK
Sbjct: 455 FYMSDVLAGGATVFPE-VGASVWPK 478
>sp|Q19673|TYR3_CAEEL Putative tyrosinase-like protein tyr-3 OS=Caenorhabditis
elegans GN=tyr-3 PE=2 SV=5
Length = 693
Score = 53 bits (126), Expect = 3e-006
Identities = 31/81 (38%), Positives = 42/81 (51%), Gaps = 13/81 (16%)
Frame = +1
Query: 757 TDPSSLHGSCPVVEGEKWSAT-RWIHVKSFERPVSRTTGCVDENESCEKWAKAGECQKNP 933
T P ++ + PVV E +S T I +K F+ T C +ENE C W+ GECQKNP
Sbjct: 439 TPPPTIQPTKPVVTVEVFSETCLKIRLKFFQ------TSCFNENECCGPWSAKGECQKNP 492
Query: 934 TYMMGSETDQGYCGKSCKACS 996
YM +C SC+ C+
Sbjct: 493 VYM------NVWCKASCRQCT 507
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,924,390,942
Number of Sequences: 518415
Number of Extensions: 86924390942
Number of Successful Extensions: 587655121
Number of sequences better than 0.0: 0
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