BLASTX 7.6.2
Query= UN20564 /QuerySize=2272
(2271 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q0VCZ3|YTHD2_BOVIN YTH domain family protein 2 OS=Bos taurus ... 215 2e-054
sp|Q9Y5A9|YTHD2_HUMAN YTH domain family protein 2 OS=Homo sapien... 214 3e-054
sp|Q4R5D9|YTHD2_MACFA YTH domain family protein 2 OS=Macaca fasc... 214 3e-054
sp|P59326|YTHD1_MOUSE YTH domain family protein 1 OS=Mus musculu... 210 4e-053
sp|Q7Z739|YTHD3_HUMAN YTH domain family protein 3 OS=Homo sapien... 210 6e-053
sp|Q8BYK6|YTHD3_MOUSE YTH domain family protein 3 OS=Mus musculu... 210 6e-053
sp|Q5RFL8|YTHD3_PONAB YTH domain family protein 3 OS=Pongo abeli... 210 6e-053
sp|Q9BYJ9|YTHD1_HUMAN YTH domain family protein 1 OS=Homo sapien... 209 1e-052
sp|Q06390|YD374_YEAST YTH domain-containing protein YDR374C OS=S... 119 1e-025
sp|B2RR83|YTDC2_MOUSE Probable ATP-dependent RNA helicase YTHDC2... 79 2e-013
sp|Q5R746|YTDC2_PONAB YTH domain-containing protein 2 OS=Pongo a... 79 2e-013
sp|Q9H6S0|YTDC2_HUMAN Probable ATP-dependent RNA helicase YTHDC2... 76 8e-013
>sp|Q0VCZ3|YTHD2_BOVIN YTH domain family protein 2 OS=Bos taurus GN=YTHDF2 PE=2
SV=1
Length = 580
Score = 215 bits (545), Expect = 2e-054
Identities = 110/205 (53%), Positives = 135/205 (65%), Gaps = 13/205 (6%)
Frame = +1
Query: 1141 TKKNSNGSPKE---------EANNSNP-DFVTDYSDARLFIIKSYSEDNVHKSIKYNVWA 1290
T+ S +P E NN NP DF + R+FIIKSYSED++H+SIKYN+W
Sbjct: 375 TQAGSGSTPSEPHPVLEKLRSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWC 434
Query: 1291 STPNGNKKLDAAYREAKDQKEPCPVFLLFSVNASSQFCGVAEMIGPVDFEKSVDYWQQDK 1470
ST +GNK+LDAAYR + PV+LLFSVN S FCGVAEM VD+ W QDK
Sbjct: 435 STEHGNKRLDAAYRSMNGKG---PVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDK 491
Query: 1471 WNGQFPVKWHIIKDVPNSQFRHIILENNDNKPVTNSRDTQEVKLEQGIEMLKIFKNYDAE 1650
W G+F V+W +KDVPNSQ RHI LENN+NKPVTNSRDTQEV LE+ ++LKI +Y
Sbjct: 492 WKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHT 551
Query: 1651 TSILDDFGFYEEREKIIQERKARRQ 1725
TSI DDF YE+R++ + K RQ
Sbjct: 552 TSIFDDFSHYEKRQEEEESVKKERQ 576
>sp|Q9Y5A9|YTHD2_HUMAN YTH domain family protein 2 OS=Homo sapiens GN=YTHDF2
PE=1 SV=2
Length = 579
Score = 214 bits (544), Expect = 3e-054
Identities = 106/183 (57%), Positives = 129/183 (70%), Gaps = 4/183 (2%)
Frame = +1
Query: 1180 NNSNP-DFVTDYSDARLFIIKSYSEDNVHKSIKYNVWASTPNGNKKLDAAYREAKDQKEP 1356
NN NP DF + R+FIIKSYSED++H+SIKYN+W ST +GNK+LDAAYR +
Sbjct: 396 NNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKG-- 453
Query: 1357 CPVFLLFSVNASSQFCGVAEMIGPVDFEKSVDYWQQDKWNGQFPVKWHIIKDVPNSQFRH 1536
PV+LLFSVN S FCGVAEM VD+ W QDKW G+F V+W +KDVPNSQ RH
Sbjct: 454 -PVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRH 512
Query: 1537 IILENNDNKPVTNSRDTQEVKLEQGIEMLKIFKNYDAETSILDDFGFYEEREKIIQERKA 1716
I LENN+NKPVTNSRDTQEV LE+ ++LKI +Y TSI DDF YE+R++ + K
Sbjct: 513 IRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEESVKK 572
Query: 1717 RRQ 1725
RQ
Sbjct: 573 ERQ 575
>sp|Q4R5D9|YTHD2_MACFA YTH domain family protein 2 OS=Macaca fascicularis
GN=YTHDF2 PE=2 SV=1
Length = 579
Score = 214 bits (544), Expect = 3e-054
Identities = 106/183 (57%), Positives = 129/183 (70%), Gaps = 4/183 (2%)
Frame = +1
Query: 1180 NNSNP-DFVTDYSDARLFIIKSYSEDNVHKSIKYNVWASTPNGNKKLDAAYREAKDQKEP 1356
NN NP DF + R+FIIKSYSED++H+SIKYN+W ST +GNK+LDAAYR +
Sbjct: 396 NNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKG-- 453
Query: 1357 CPVFLLFSVNASSQFCGVAEMIGPVDFEKSVDYWQQDKWNGQFPVKWHIIKDVPNSQFRH 1536
PV+LLFSVN S FCGVAEM VD+ W QDKW G+F V+W +KDVPNSQ RH
Sbjct: 454 -PVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRH 512
Query: 1537 IILENNDNKPVTNSRDTQEVKLEQGIEMLKIFKNYDAETSILDDFGFYEEREKIIQERKA 1716
I LENN+NKPVTNSRDTQEV LE+ ++LKI +Y TSI DDF YE+R++ + K
Sbjct: 513 IRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEESVKK 572
Query: 1717 RRQ 1725
RQ
Sbjct: 573 ERQ 575
>sp|P59326|YTHD1_MOUSE YTH domain family protein 1 OS=Mus musculus GN=Ythdf1
PE=2 SV=1
Length = 559
Score = 210 bits (534), Expect = 4e-053
Identities = 103/186 (55%), Positives = 133/186 (71%), Gaps = 7/186 (3%)
Frame = +1
Query: 1177 ANNSNP-DFVTDYSDARLFIIKSYSEDNVHKSIKYNVWASTPNGNKKLDAAYREAKDQKE 1353
A++ NP +F + R+FIIKSYSED++H+SIKY++W ST +GNK+LD A+R +
Sbjct: 374 AHSYNPKEFDWNLKSGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDGAFRSMSSKG- 432
Query: 1354 PCPVFLLFSVNASSQFCGVAEMIGPVDFEKSVDYWQQDKWNGQFPVKWHIIKDVPNSQFR 1533
PV+LLFSVN S FCGVAEM PVD+ S W QDKW G+F VKW +KDVPN+Q R
Sbjct: 433 --PVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVKWIFVKDVPNNQLR 490
Query: 1534 HIILENNDNKPVTNSRDTQEVKLEQGIEMLKIFKNYDAETSILDDFGFYEER---EKIIQ 1704
HI LENNDNKPVTNSRDTQEV LE+ ++LKI +Y TSI DDF YE+R E++++
Sbjct: 491 HIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEEVVR 550
Query: 1705 ERKARR 1722
+ + R
Sbjct: 551 KERQNR 556
>sp|Q7Z739|YTHD3_HUMAN YTH domain family protein 3 OS=Homo sapiens GN=YTHDF3
PE=1 SV=1
Length = 585
Score = 210 bits (532), Expect = 6e-053
Identities = 104/183 (56%), Positives = 130/183 (71%), Gaps = 6/183 (3%)
Frame = +1
Query: 1180 NNSNP-DFVTDYSDARLFIIKSYSEDNVHKSIKYNVWASTPNGNKKLDAAYREAKDQKEP 1356
NN NP DF + + R+FIIKSYSED++H+SIKY++W ST +GNK+LDAAYR +
Sbjct: 402 NNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKG-- 459
Query: 1357 CPVFLLFSVNASSQFCGVAEMIGPVDFEKSVDYWQQDKWNGQFPVKWHIIKDVPNSQFRH 1536
P++LLFSVN S FCGVAEM VD+ W QDKW G+F VKW +KDVPN+Q RH
Sbjct: 460 -PLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRH 518
Query: 1537 IILENNDNKPVTNSRDTQEVKLEQGIEMLKIFKNYDAETSILDDFGFYEEREKIIQERKA 1716
I LENNDNKPVTNSRDTQEV LE+ ++LKI + TSI DDF YE+R++ +E
Sbjct: 519 IRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQE--EEEAM 576
Query: 1717 RRQ 1725
RR+
Sbjct: 577 RRE 579
>sp|Q8BYK6|YTHD3_MOUSE YTH domain family protein 3 OS=Mus musculus GN=Ythdf3
PE=1 SV=2
Length = 585
Score = 210 bits (532), Expect = 6e-053
Identities = 104/183 (56%), Positives = 130/183 (71%), Gaps = 6/183 (3%)
Frame = +1
Query: 1180 NNSNP-DFVTDYSDARLFIIKSYSEDNVHKSIKYNVWASTPNGNKKLDAAYREAKDQKEP 1356
NN NP DF + + R+FIIKSYSED++H+SIKY++W ST +GNK+LDAAYR +
Sbjct: 402 NNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKG-- 459
Query: 1357 CPVFLLFSVNASSQFCGVAEMIGPVDFEKSVDYWQQDKWNGQFPVKWHIIKDVPNSQFRH 1536
P++LLFSVN S FCGVAEM VD+ W QDKW G+F VKW +KDVPN+Q RH
Sbjct: 460 -PLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRH 518
Query: 1537 IILENNDNKPVTNSRDTQEVKLEQGIEMLKIFKNYDAETSILDDFGFYEEREKIIQERKA 1716
I LENNDNKPVTNSRDTQEV LE+ ++LKI + TSI DDF YE+R++ +E
Sbjct: 519 IRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQE--EEEAM 576
Query: 1717 RRQ 1725
RR+
Sbjct: 577 RRE 579
>sp|Q5RFL8|YTHD3_PONAB YTH domain family protein 3 OS=Pongo abelii GN=YTHDF3
PE=2 SV=1
Length = 585
Score = 210 bits (532), Expect = 6e-053
Identities = 104/183 (56%), Positives = 130/183 (71%), Gaps = 6/183 (3%)
Frame = +1
Query: 1180 NNSNP-DFVTDYSDARLFIIKSYSEDNVHKSIKYNVWASTPNGNKKLDAAYREAKDQKEP 1356
NN NP DF + + R+FIIKSYSED++H+SIKY++W ST +GNK+LDAAYR +
Sbjct: 402 NNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKG-- 459
Query: 1357 CPVFLLFSVNASSQFCGVAEMIGPVDFEKSVDYWQQDKWNGQFPVKWHIIKDVPNSQFRH 1536
P++LLFSVN S FCGVAEM VD+ W QDKW G+F VKW +KDVPN+Q RH
Sbjct: 460 -PLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRH 518
Query: 1537 IILENNDNKPVTNSRDTQEVKLEQGIEMLKIFKNYDAETSILDDFGFYEEREKIIQERKA 1716
I LENNDNKPVTNSRDTQEV LE+ ++LKI + TSI DDF YE+R++ +E
Sbjct: 519 IRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQE--EEEAM 576
Query: 1717 RRQ 1725
RR+
Sbjct: 577 RRE 579
>sp|Q9BYJ9|YTHD1_HUMAN YTH domain family protein 1 OS=Homo sapiens GN=YTHDF1
PE=1 SV=1
Length = 559
Score = 209 bits (530), Expect = 1e-052
Identities = 104/188 (55%), Positives = 135/188 (71%), Gaps = 8/188 (4%)
Frame = +1
Query: 1177 ANNSNP-DFVTDYSDARLFIIKSYSEDNVHKSIKYNVWASTPNGNKKLDAAYREAKDQKE 1353
A++ NP +F + R+FIIKSYSED++H+SIKY++W ST +GNK+LD+A+R +
Sbjct: 374 AHSYNPKEFEWNLKSGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDSAFRCMSSKG- 432
Query: 1354 PCPVFLLFSVNASSQFCGVAEMIGPVDFEKSVDYWQQDKWNGQFPVKWHIIKDVPNSQFR 1533
PV+LLFSVN S FCGVAEM PVD+ S W QDKW G+F V+W +KDVPN+Q R
Sbjct: 433 --PVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVQWIFVKDVPNNQLR 490
Query: 1534 HIILENNDNKPVTNSRDTQEVKLEQGIEMLKIFKNYDAETSILDDFGFYEER----EKII 1701
HI LENNDNKPVTNSRDTQEV LE+ ++LKI +Y TSI DDF YE+R E +
Sbjct: 491 HIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIISSYKHTTSIFDDFAHYEKRQEEEEVVR 550
Query: 1702 QERKARRQ 1725
+ER++R +
Sbjct: 551 KERQSRNK 558
>sp|Q06390|YD374_YEAST YTH domain-containing protein YDR374C OS=Saccharomyces
cerevisiae GN=YDR374C PE=2 SV=1
Length = 306
Score = 119 bits (296), Expect = 1e-025
Identities = 58/161 (36%), Positives = 97/161 (60%), Gaps = 5/161 (3%)
Frame = +1
Query: 1192 PDFVTDYSDARLFIIKSYSEDNVHKSIKYNVWASTPNGNKKLDAAYREAKDQKEPCPVFL 1371
P ++ ++R F+IKS S +V +S +W+ST GNK+L AY++ + VFL
Sbjct: 146 PPWLNIPENSRFFVIKSSSLKHVKRSFYNGIWSSTHFGNKRLSEAYKKLNSGAK---VFL 202
Query: 1372 LFSVNASSQFCGVAEMIGPVDFEKSVDYWQ-QDKWNGQFPVKWHIIKDVPNSQFRHIILE 1548
FS+N S +FCGVAEM+ + + W+ + K+ F V+W I++D+ N + ++
Sbjct: 203 FFSINTSGRFCGVAEMVSDLKMDLDTSIWEDEQKYGKAFKVRWVIVRDINNRSLKRFLIP 262
Query: 1549 NNDNKPVTNSRDTQEVKLEQGIEMLKIFKNYDAET-SILDD 1668
+N+ KP+T+SRDTQE+ GI ++ +FK D++ S LD+
Sbjct: 263 SNEMKPITHSRDTQEIPYSIGISIINLFKTQDSDIFSFLDE 303
>sp|B2RR83|YTDC2_MOUSE Probable ATP-dependent RNA helicase YTHDC2 OS=Mus
musculus GN=Ythdc2 PE=2 SV=1
Length = 1445
Score = 79 bits (192), Expect = 2e-013
Identities = 56/189 (29%), Positives = 91/189 (48%), Gaps = 15/189 (7%)
Frame = +1
Query: 1093 LKPKAQVSEELDSSADTKKNSNGSPKEEANNSNPDFVTDYSD--------ARLFIIKSYS 1248
L PK + D S+ +S+ P A+ S P R FI+KS +
Sbjct: 1253 LHPKRSTDDRSDQSSVKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPIRYFIMKSSN 1312
Query: 1249 EDNVHKSIKYNVWASTPNGNKKLDAAYREAKDQKEPCPVFLLFSVNASSQFCGVAEMIGP 1428
N+ S + +W++TP+ +KL+ A+ E+ V+L+FSV S F G + M
Sbjct: 1313 LRNLEISQQKGIWSTTPSNERKLNRAFWESS------MVYLVFSVQGSGHFQGFSRMSSE 1366
Query: 1429 VDFEKSVDYWQQDKWNGQFPVKWHIIKDVPNSQFRHIILENNDNKPVTNSRDTQEVKLEQ 1608
+ EKS D W G F V+W + +P H++ NDNK V SRD QE++ +
Sbjct: 1367 IGREKSQD-WGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPQV 1425
Query: 1609 GIEMLKIFK 1635
G ++L++++
Sbjct: 1426 GEQLLQLWE 1434
>sp|Q5R746|YTDC2_PONAB YTH domain-containing protein 2 OS=Pongo abelii GN=YTHDC2
PE=2 SV=1
Length = 671
Score = 79 bits (192), Expect = 2e-013
Identities = 52/170 (30%), Positives = 85/170 (50%), Gaps = 7/170 (4%)
Frame = +1
Query: 1126 DSSADTKKNSNGSPKEEANNSNPDFVTDYSDARLFIIKSYSEDNVHKSIKYNVWASTPNG 1305
DSS+ ++ SP S R FI+KS + N+ S + +W++TP+
Sbjct: 498 DSSSYPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEISQQKGIWSTTPSN 557
Query: 1306 NKKLDAAYREAKDQKEPCPVFLLFSVNASSQFCGVAEMIGPVDFEKSVDYWQQDKWNGQF 1485
+KL+ A+ E+ V+L+FSV S F G + M + EKS D W G F
Sbjct: 558 ERKLNRAFWESS------MVYLVFSVQGSGHFQGFSRMSSEIGREKSQD-WGSAGLGGVF 610
Query: 1486 PVKWHIIKDVPNSQFRHIILENNDNKPVTNSRDTQEVKLEQGIEMLKIFK 1635
V+W + +P H++ NDNK V SRD QE++ + G ++L++++
Sbjct: 611 KVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPQVGEQLLQLWE 660
>sp|Q9H6S0|YTDC2_HUMAN Probable ATP-dependent RNA helicase YTHDC2 OS=Homo
sapiens GN=YTHDC2 PE=1 SV=2
Length = 1430
Score = 76 bits (186), Expect = 8e-013
Identities = 52/170 (30%), Positives = 84/170 (49%), Gaps = 7/170 (4%)
Frame = +1
Query: 1126 DSSADTKKNSNGSPKEEANNSNPDFVTDYSDARLFIIKSYSEDNVHKSIKYNVWASTPNG 1305
DSS+ ++ SP S R FI+KS + N+ S + +W++TP+
Sbjct: 1257 DSSSYPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEISQQKGIWSTTPSN 1316
Query: 1306 NKKLDAAYREAKDQKEPCPVFLLFSVNASSQFCGVAEMIGPVDFEKSVDYWQQDKWNGQF 1485
+KL+ A+ E+ V+L+FSV S F G + M + EKS D W G F
Sbjct: 1317 ERKLNRAFWESS------IVYLVFSVQGSGHFQGFSRMSSEIGREKSQD-WGSAGLGGVF 1369
Query: 1486 PVKWHIIKDVPNSQFRHIILENNDNKPVTNSRDTQEVKLEQGIEMLKIFK 1635
V+W + +P H++ NDNK V SRD QE++ G ++L++++
Sbjct: 1370 KVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPLVGEQLLQLWE 1419
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,924,390,942
Number of Sequences: 518415
Number of Extensions: 86924390942
Number of Successful Extensions: 587655121
Number of sequences better than 0.0: 0
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