BLASTX 7.6.2

Query= UN20630 /QuerySize=1160
        (1159 letters)

Database: UniProt/SwissProt;
          518,415 sequences; 182,829,261 total letters
                                                                  Score    E
Sequences producing significant alignments:                       (bits) Value

sp|Q9NUN7|ACER3_HUMAN Alkaline ceramidase 3 OS=Homo sapiens GN=A...    127   1e-028
sp|P38298|YPC1_YEAST Alkaline ceramidase YPC1 OS=Saccharomyces c...     78   1e-013
sp|Q02896|YDC1_YEAST Alkaline ceramidase YDC1 OS=Saccharomyces c...     77   2e-013
sp|Q8TDN7|ACER1_HUMAN Alkaline ceramidase 1 OS=Homo sapiens GN=A...     62   7e-009
sp|Q9VIP7|ACASE_DROME Alkaline ceramidase OS=Drosophila melanoga...     57   3e-007
sp|Q8R4X1|ACER1_MOUSE Alkaline ceramidase 1 OS=Mus musculus GN=A...     57   3e-007

>sp|Q9NUN7|ACER3_HUMAN Alkaline ceramidase 3 OS=Homo sapiens GN=ACER3 PE=1 SV=3

          Length = 267

 Score =  127 bits (319), Expect = 1e-028
 Identities = 73/258 (28%), Positives = 128/258 (49%), Gaps = 20/258 (7%)
 Frame = +2

Query: 218 FWGPVTSTIECCEKNYSYSSYIAEFYNTISNVPGILLALIGLVNALRQRFEKRFSILHIS 397
           +WGP TST++ CE+NYS + YIAEF+NT+SN+  I+  + G V ++R   EKR+   +++
Sbjct:  10 YWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLA 69

Query: 398 NMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILY-------SPDWHYRSTMPTFL 556
             ++ +GS  +H TL++  Q  DE PM++   +++Y ++       S ++H   T    L
Sbjct:  70 LTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFT----L 125

Query: 557 FLYGAAFAVVHAFLRFGIGFKVHYVVLCLLCIPRMYKYYIHTEDTAAKRIAKWYVATILV 736
            L+      V+  ++  I  +V Y +L    + R   Y +       + +    +   L+
Sbjct: 126 VLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSI-YIVTWVYPWLRGLGYTSLGIFLL 184

Query: 737 GSVCWFCDRVFCERISQW--------PVNPQGHALWHVFMSFNSYCANTFLMFCRAQQRG 892
           G + W  D +FCE +  +         +  Q HA WH+     SY    F ++ R     
Sbjct: 185 GFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLR 244

Query: 893 WNPKVKYFLGVLPYVKIE 946
           + PKVK+  G+ P +  E
Sbjct: 245 YRPKVKFLFGIWPVILFE 262

>sp|P38298|YPC1_YEAST Alkaline ceramidase YPC1 OS=Saccharomyces cerevisiae
        GN=YPC1 PE=1 SV=1

          Length = 316

 Score =  78 bits (190), Expect = 1e-013
 Identities = 37/96 (38%), Positives = 59/96 (61%)
 Frame = +2

Query: 209 ISSFWGPVTSTIECCEKNYSYSSYIAEFYNTISNVPGILLALIGLVNALRQRFEKRFSIL 388
           +   WG  TSTI+ CE+NY  S YIAE+ NT++N   IL A+    +A + + EKRF ++
Sbjct:  13 VPGVWGETTSTIDWCEENYVVSPYIAEWSNTLTNSVFILSAIYTTYSAYKNKLEKRFLLI 72

Query: 389 HISNMILAIGSMLYHATLQHVQQQSDETPMVWEILL 496
                ++ +GS L+H TL++  Q  DE PM++ + +
Sbjct:  73 GFGYGLVGVGSWLFHMTLKYRFQLLDELPMIYAMCI 108

>sp|Q02896|YDC1_YEAST Alkaline ceramidase YDC1 OS=Saccharomyces cerevisiae
        GN=YDC1 PE=1 SV=1

          Length = 317

 Score =  77 bits (189), Expect = 2e-013
 Identities = 37/103 (35%), Positives = 62/103 (60%)
 Frame = +2

Query: 209 ISSFWGPVTSTIECCEKNYSYSSYIAEFYNTISNVPGILLALIGLVNALRQRFEKRFSIL 388
           I  +WG  TS I+ CE+NY  S YIAE+ NTI+N   ++ A     +A R + E R+ ++
Sbjct:  12 IEGYWGKPTSLIDWCEENYVVSPYIAEWSNTITNSIFLMTAFYSTYSAWRNKLETRYILI 71

Query: 389 HISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYS 517
            +   ++ IGS L+H TLQ+  Q  DE PM++  ++  + +++
Sbjct:  72 GMGFSLVGIGSWLFHMTLQYRYQLLDELPMLYATIIPSWSIFA 114

>sp|Q8TDN7|ACER1_HUMAN Alkaline ceramidase 1 OS=Homo sapiens GN=ACER1 PE=2 SV=1

          Length = 264

 Score =  62 bits (149), Expect = 7e-009
 Identities = 35/110 (31%), Positives = 61/110 (55%), Gaps = 7/110 (6%)
 Frame = +2

Query: 233 TSTIECCEKNYSYSSYIAEFYNTISNVPGILLA--LIGLVNALRQRFEKRFSILHISNMI 406
           +S ++ CE N+ YS  +AEFYNT SN+P  +    ++ L++   Q+  +   ++ +  MI
Sbjct:   9 SSEVDWCESNFQYSELVAEFYNTFSNIPFFIFGPLMMLLMHPYAQKRSRYIYVVWVLFMI 68

Query: 407 LAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWHYRSTMPTFL 556
           + + SM +H TL  + Q  DE  ++W +L   Y ++ P    R   P+FL
Sbjct:  69 IGLFSMYFHMTLSFLGQLLDEIAILW-LLGSGYSIWMP----RCYFPSFL 113

>sp|Q9VIP7|ACASE_DROME Alkaline ceramidase OS=Drosophila melanogaster GN=bwa
        PE=2 SV=2

          Length = 283

 Score =  57 bits (135), Expect = 3e-007
 Identities = 35/104 (33%), Positives = 55/104 (52%), Gaps = 3/104 (2%)
 Frame = +2

Query: 227 PVTSTIECCEKNYSYSSYIAEFYNTISNVPGILL--ALIGLVNALRQRFEKRFSILHISN 400
           P +S ++ CE NY  SS IAEF NT SN   ILL   LI L     +       ++ +  
Sbjct:  22 PGSSPVDWCEGNYLISSNIAEFVNTFSNFLFILLPPVLIMLFKEYGRFVTPGIHVIWVLL 81

Query: 401 MILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWHY 532
           +++ + SM +HATL  + Q  DE  ++W + +  + L+ P  +Y
Sbjct:  82 IVVGLSSMYFHATLSLIGQLLDELAILW-VFMAAFSLFYPKRYY 124

>sp|Q8R4X1|ACER1_MOUSE Alkaline ceramidase 1 OS=Mus musculus GN=Acer1 PE=1 SV=1

          Length = 273

 Score =  57 bits (135), Expect = 3e-007
 Identities = 32/110 (29%), Positives = 62/110 (56%), Gaps = 3/110 (2%)
 Frame = +2

Query: 209 ISSFWGPVTSTIECCEKNYSYSSYIAEFYNTISNVPGILLA--LIGLVNALRQRFEKRFS 382
           +SS +   +S ++ CE N+ +S  +AEFYNT SNV  ++    ++ L++   Q+  + F 
Sbjct:  10 MSSIFAYQSSEVDWCESNFQHSELVAEFYNTFSNVFFLIFGPLMMFLMHPYAQKRTRCFY 69

Query: 383 ILHISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWHY 532
            + +  M++ + SM +H TL  + Q  DE  ++W +L   Y ++ P  ++
Sbjct:  70 GVSVLFMLIGLFSMYFHMTLSFLGQLLDEISILW-LLASGYSVWLPRCYF 118

  Database: UniProt/SwissProt
    Posted date:  Sat Aug 07 14:36:18 2010
  Number of letters in database: 182,829,261
  Number of sequences in database:  518,415

Lambda     K     H
   0.267   0.041    0.140
Gapped
Lambda     K     H
   0.267   0.041    0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,924,390,942
Number of Sequences: 518415
Number of Extensions: 86924390942
Number of Successful Extensions: 587655121
Number of sequences better than 0.0: 0