BLASTX 7.6.2
Query= UN20645 /QuerySize=2695
(2694 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q60560|SMBP2_MESAU DNA-binding protein SMUBP-2 OS=Mesocricetu... 330 4e-089
sp|Q9EQN5|SMBP2_RAT DNA-binding protein SMUBP-2 OS=Rattus norveg... 330 4e-089
sp|P38935|SMBP2_HUMAN DNA-binding protein SMUBP-2 OS=Homo sapien... 328 2e-088
sp|P40694|SMBP2_MOUSE DNA-binding protein SMUBP-2 OS=Mus musculu... 323 5e-087
sp|Q09820|RENT1_SCHPO Regulator of nonsense transcripts 1 homolo... 180 5e-044
sp|O94247|HCS1_SCHPO DNA polymerase alpha-associated DNA helicas... 158 2e-037
sp|P34243|HCS1_YEAST DNA polymerase alpha-associated DNA helicas... 93 8e-018
sp|O76512|RENT1_CAEEL Regulator of nonsense transcripts 1 OS=Cae... 77 6e-013
sp|Q9HEH1|RENT1_NEUCR Regulator of nonsense transcripts 1 homolo... 75 2e-012
sp|Q9FJR0|RENT1_ARATH Regulator of nonsense transcripts 1 homolo... 74 4e-012
sp|P30771|NAM7_YEAST ATP-dependent helicase NAM7 OS=Saccharomyce... 72 1e-011
sp|Q54I89|RENT1_DICDI Regulator of nonsense transcripts 1 OS=Dic... 72 1e-011
sp|Q92900|RENT1_HUMAN Regulator of nonsense transcripts 1 OS=Hom... 70 7e-011
sp|Q9EPU0|RENT1_MOUSE Regulator of nonsense transcripts 1 OS=Mus... 70 9e-011
sp|Q98TR3|RENT1_TAKRU Putative regulator of nonsense transcripts... 69 2e-010
sp|Q9VYS3|RENT1_DROME Regulator of nonsense transcripts 1 homolo... 67 5e-010
sp|P32644|ECM32_YEAST Putative ATP-dependent RNA helicase ECM32 ... 63 1e-008
>sp|Q60560|SMBP2_MESAU DNA-binding protein SMUBP-2 OS=Mesocricetus auratus
GN=IGHMBP2 PE=1 SV=1
Length = 989
Score = 330 bits (845), Expect = 4e-089
Identities = 212/535 (39%), Positives = 304/535 (56%), Gaps = 40/535 (7%)
Frame = -3
Query: 1900 RIHGLADALTYERNCEALMPLQKNGLQKKNPSISVVATLFGDGEDITWLEQNDYVDWSEA 1721
R+ LA+ +TY+R +ALM L+K P+ S++ L G E + ++ A
Sbjct: 134 RLLKLANDVTYKRLKKALMTLKK---YHSGPASSLIDVLLGGSSPSPTTEIPPFTFYNTA 190
Query: 1720 ELSDEPVGKLFDDSQRRAIALGVNKKRPVMIVQGPPGTGKTGMLKEVITLAVQQGERVLV 1541
D SQ+ A++ + +K V I+ GPPGTGKT + E+I AV+QG ++L
Sbjct: 191 ----------LDPSQKEAVSFALAQKE-VAIIHGPPGTGKTTTVVEIILQAVKQGLKILC 239
Query: 1540 TAPTNAAVDNMVEKLSHLGLNIVRVGNPARISSAVASKSLGEIVNSKLASFRAELERKKS 1361
AP+N AVDN+VE+L+ I+R+G+PAR+ + SL ++ R++ + +
Sbjct: 240 CAPSNVAVDNLVERLALCKKRILRLGHPARLLESAQQHSLDAVL------ARSDNAQIVA 293
Query: 1360 DLRKDLRQCL------RDDSLATGIRQLLKQLGKTLKKKEKETVKEILSNAQVVFATNIG 1199
D+RKD+ Q +D + R +K L K LK++E+ + + L+ A VV ATN G
Sbjct: 294 DIRKDIDQVFGKNKKTQDKREKSNFRNEIKLLRKELKEREEAAIVQSLTAADVVLATNTG 353
Query: 1198 -SADPLIRML--DTFDLVVIDEAGQSIEPSCWIPILQGKRCILAGDPCQLAPVVLSRKAL 1028
S+D +++L + FD+VV+DE Q++E SCWIP+L+ +CILAGD QL P +S KA
Sbjct: 354 ASSDGPLKLLPENHFDVVVVDECAQALEASCWIPLLKAPKCILAGDHRQLPPTTISHKAA 413
Query: 1027 EDGLGVSLLERAASLHDGLLATKLSTQYRMNDVIAGWASKEMYGGWLKSSPSVASHLLID 848
GL SL+ER H L+ QYRM+ I WAS+ MY G L + PSVA HLL D
Sbjct: 414 LAGLSRSLMERLVEKHGAGAVRMLTVQYRMHQAITRWASEAMYHGQLTAHPSVAGHLLKD 473
Query: 847 SPFVKPTWITQCPLLLLDTRMPYGSLSVGCE-ERLDPAGTGSLYNEGEADIVVNHVISLI 671
P V T T PLLL+DT GC LD + S N GE +V H+ +L+
Sbjct: 474 LPGVADTEETSVPLLLIDT--------AGCGLLELDEEDSQSKGNPGEVRLVTLHIQALV 525
Query: 670 YAGVSQMAIAVQSPYVAQVQLPRERLDEFPVADGVEVATIDSFQGREANAVIISMVRSNN 491
AGV IAV +PY QV L R+ L +E+ ++D FQGRE AVI++ VRSN
Sbjct: 526 DAGVHAGDIAVIAPYNLQVDLLRQSLSN--KHPELEIKSVDGFQGREKEAVILTFVRSNR 583
Query: 490 LGAVGFLGDSRRMNVAITRARKHVAVVCDSSTICHNTFLARLLRHIRYFGRVKHA 326
G VGFL + RR+NVA+TRAR+HVAV+CDS T+ ++ FL L+ + G V+ A
Sbjct: 584 KGEVGFLAEDRRINVAVTRARRHVAVICDSRTVNNHAFLKTLVDYFTEHGEVRTA 638
>sp|Q9EQN5|SMBP2_RAT DNA-binding protein SMUBP-2 OS=Rattus norvegicus GN=Ighmbp2
PE=1 SV=1
Length = 988
Score = 330 bits (845), Expect = 4e-089
Identities = 213/535 (39%), Positives = 304/535 (56%), Gaps = 40/535 (7%)
Frame = -3
Query: 1900 RIHGLADALTYERNCEALMPLQKNGLQKKNPSISVVATLFGDGEDITWLEQNDYVDWSEA 1721
R+ LA+ +TY+R +AL+ L+K P+ S++ L G E ++
Sbjct: 134 RLLKLANDVTYKRLKKALLTLKK---YHSGPASSLIDVLLGGSTPSPATEIPPLTFYNTT 190
Query: 1720 ELSDEPVGKLFDDSQRRAIALGVNKKRPVMIVQGPPGTGKTGMLKEVITLAVQQGERVLV 1541
D SQ+ A++ + +K V I+ GPPGTGKT + E+I AV+QG +VL
Sbjct: 191 ----------LDPSQKEAVSFALAQKE-VAIIHGPPGTGKTTTVVEIILQAVKQGLKVLC 239
Query: 1540 TAPTNAAVDNMVEKLSHLGLNIVRVGNPARISSAVASKSLGEIVNSKLASFRAELERKKS 1361
AP+N AVDN+VE+L+ I+R+G+PAR+ +V SL ++ R++ + +
Sbjct: 240 CAPSNIAVDNLVERLALCKKQILRLGHPARLLESVQQHSLDAVL------ARSDNAQIVA 293
Query: 1360 DLRKDLRQCL------RDDSLATGIRQLLKQLGKTLKKKEKETVKEILSNAQVVFATNIG 1199
D+R+D+ Q +D + R +K L K LK++E+ + + LS A VV ATN G
Sbjct: 294 DIRRDIDQVFGKNKKTQDKREKSNFRNEIKLLRKELKEREEAAIVQSLSAADVVLATNTG 353
Query: 1198 -SADPLIRML--DTFDLVVIDEAGQSIEPSCWIPILQGKRCILAGDPCQLAPVVLSRKAL 1028
S D +++L D FD+VV+DE Q++E SCWIP+L+ +CILAGD QL P +S KA
Sbjct: 354 ASTDGPLKLLPEDYFDVVVVDECAQALEASCWIPLLKAPKCILAGDHKQLPPTTVSHKAA 413
Query: 1027 EDGLGVSLLERAASLHDGLLATKLSTQYRMNDVIAGWASKEMYGGWLKSSPSVASHLLID 848
GL SL+ER A H + L+ QYRM+ I WAS+ MY G L + PSVA HLL D
Sbjct: 414 LAGLSRSLMERLAEKHGAAVVRMLAVQYRMHQAITRWASEAMYHGQLTAHPSVAGHLLKD 473
Query: 847 SPFVKPTWITQCPLLLLDTRMPYGSLSVGCE-ERLDPAGTGSLYNEGEADIVVNHVISLI 671
P V T T PLLL+DT GC L+ + S N GE +V H+ +L+
Sbjct: 474 LPGVADTEETSVPLLLIDT--------AGCGLLELEEEDSQSKGNPGEVRLVTLHIQALV 525
Query: 670 YAGVSQMAIAVQSPYVAQVQLPRERLDEFPVADGVEVATIDSFQGREANAVIISMVRSNN 491
AGV IAV +PY QV L R+ L +E+ ++D FQGRE AVI++ VRSN
Sbjct: 526 DAGVQAGDIAVIAPYNLQVDLLRQSLSN--KHPELEIKSVDGFQGREKEAVILTFVRSNR 583
Query: 490 LGAVGFLGDSRRMNVAITRARKHVAVVCDSSTICHNTFLARLLRHIRYFGRVKHA 326
G VGFL + RR+NVA+TRAR+HVAV+CDS T+ ++ FL L+ + G V+ A
Sbjct: 584 KGEVGFLAEDRRINVAVTRARRHVAVICDSHTVNNHAFLKTLVDYFTEHGEVRTA 638
>sp|P38935|SMBP2_HUMAN DNA-binding protein SMUBP-2 OS=Homo sapiens GN=IGHMBP2
PE=1 SV=2
Length = 993
Score = 328 bits (839), Expect = 2e-088
Identities = 215/536 (40%), Positives = 307/536 (57%), Gaps = 42/536 (7%)
Frame = -3
Query: 1900 RIHGLADALTYERNCEALMPLQKNGLQKKNPSISVVATLFGDGEDITWLEQNDYVDWSEA 1721
R+ LA+ +TY R +AL+ L+K P+ S++ LFG E + ++
Sbjct: 135 RLLKLANDVTYRRLKKALIALKK---YHSGPASSLIEVLFGRSAPSPASEIHPLTFFNTC 191
Query: 1720 ELSDEPVGKLFDDSQRRAIALGVNKKRPVMIVQGPPGTGKTGMLKEVITLAVQQGERVLV 1541
D SQ+ A++ +++K + I+ GPPGTGKT + E+I AV+QG +VL
Sbjct: 192 ----------LDTSQKEAVSFALSQKE-LAIIHGPPGTGKTTTVVEIILQAVKQGLKVLC 240
Query: 1540 TAPTNAAVDNMVEKLSHLGLNIVRVGNPARISSAVASKSLGEIVNSKLASFRAELERKKS 1361
AP+N AVDN+VE+L+ I+R+G+PAR+ ++ SL ++ R++ + +
Sbjct: 241 CAPSNIAVDNLVERLALCKQRILRLGHPARLLESIQQHSLDAVL------ARSDSAQIVA 294
Query: 1360 DLRKDLRQCL------RDDSLATGIRQLLKQLGKTLKKKEKETVKEILSNAQVVFATNIG 1199
D+RKD+ Q +D + R +K L K LK++E+ + E L++A VV ATN G
Sbjct: 295 DIRKDIDQVFVKNKKTQDKREKSNFRNEIKLLRKELKEREEAAMLESLTSANVVLATNTG 354
Query: 1198 -SADPLIRML--DTFDLVVIDEAGQSIEPSCWIPILQGKRCILAGDPCQLAPVVLSRKAL 1028
SAD +++L FD+VVIDE Q++E SCWIP+L+ ++CILAGD QL P +S KA
Sbjct: 355 ASADGPLKLLPESYFDVVVIDECAQALEASCWIPLLKARKCILAGDHKQLPPTTVSHKAA 414
Query: 1027 EDGLGVSLLERAASLHDGLLATKLSTQYRMNDVIAGWASKEMYGGWLKSSPSVASHLLID 848
GL +SL+ER A + + L+ QYRM+ I WAS MY G L + SVA HLL D
Sbjct: 415 LAGLSLSLMERLAEEYGARVVRTLTVQYRMHQAIMRWASDTMYLGQLTAHSSVARHLLRD 474
Query: 847 SPFVKPTWITQCPLLLLDTRMPYGSLSVGCE-ERLDPAGTGSLYNEGEADIVVNHVISLI 671
P V T T PLLL+DT GC L+ S N GE +V H+ +L+
Sbjct: 475 LPGVAATEETGVPLLLVDT--------AGCGLFELEEEDEQSKGNPGEVRLVSLHIQALV 526
Query: 670 YAGVSQMAIAVQSPYVAQVQLPRERL-DEFPVADGVEVATIDSFQGREANAVIISMVRSN 494
AGV IAV SPY QV L R+ L P +E+ ++D FQGRE AVI+S VRSN
Sbjct: 527 DAGVPARDIAVVSPYNLQVDLLRQSLVHRHP---ELEIKSVDGFQGREKEAVILSFVRSN 583
Query: 493 NLGAVGFLGDSRRMNVAITRARKHVAVVCDSSTICHNTFLARLLRHIRYFGRVKHA 326
G VGFL + RR+NVA+TRAR+HVAV+CDS T+ ++ FL L+ + G V+ A
Sbjct: 584 RKGEVGFLAEDRRINVAVTRARRHVAVICDSRTVNNHAFLKTLVEYFTQHGEVRTA 639
>sp|P40694|SMBP2_MOUSE DNA-binding protein SMUBP-2 OS=Mus musculus GN=Ighmbp2
PE=1 SV=1
Length = 993
Score = 323 bits (827), Expect = 5e-087
Identities = 210/535 (39%), Positives = 305/535 (57%), Gaps = 40/535 (7%)
Frame = -3
Query: 1900 RIHGLADALTYERNCEALMPLQKNGLQKKNPSISVVATLFGDGEDITWLEQNDYVDWSEA 1721
R+ LA+ +TY+R +ALM L+K P+ S++ L G +E ++
Sbjct: 134 RLLKLANDVTYKRLKKALMTLKK---YHSGPASSLIDILLGSSTPSPAMEIPPLSFYNTT 190
Query: 1720 ELSDEPVGKLFDDSQRRAIALGVNKKRPVMIVQGPPGTGKTGMLKEVITLAVQQGERVLV 1541
D SQ+ A++ + +K + I+ GPPGTGKT + E+I AV+QG +VL
Sbjct: 191 ----------LDLSQKEAVSFALAQKE-LAIIHGPPGTGKTTTVVEIILQAVKQGLKVLC 239
Query: 1540 TAPTNAAVDNMVEKLSHLGLNIVRVGNPARISSAVASKSLGEIVNSKLASFRAELERKKS 1361
AP+N AVDN+VE+L+ I+R+G+PAR+ +V SL ++ R++ + +
Sbjct: 240 CAPSNIAVDNLVERLALCKKRILRLGHPARLLESVQHHSLDAVL------ARSDNAQIVA 293
Query: 1360 DLRKDLRQCL------RDDSLATGIRQLLKQLGKTLKKKEKETVKEILSNAQVVFATNIG 1199
D+R+D+ Q +D R +K L K LK++E+ + + L+ A VV ATN G
Sbjct: 294 DIRRDIDQVFGKNKKTQDKREKGNFRSEIKLLRKELKEREEAAIVQSLTAADVVLATNTG 353
Query: 1198 -SADPLIRML--DTFDLVVIDEAGQSIEPSCWIPILQGKRCILAGDPCQLAPVVLSRKAL 1028
S+D +++L D FD+VV+DE Q++E SCWIP+L+ +CILAGD QL P +S +A
Sbjct: 354 ASSDGPLKLLPEDYFDVVVVDECAQALEASCWIPLLKAPKCILAGDHRQLPPTTVSHRAA 413
Query: 1027 EDGLGVSLLERAASLHDGLLATKLSTQYRMNDVIAGWASKEMYGGWLKSSPSVASHLLID 848
GL SL+ER A H + L+ QYRM+ I WAS+ MY G S PSVA HLL D
Sbjct: 414 LAGLSRSLMERLAEKHGAGVVRMLTVQYRMHQAIMCWASEAMYHGQFTSHPSVAGHLLKD 473
Query: 847 SPFVKPTWITQCPLLLLDTRMPYGSLSVGCE-ERLDPAGTGSLYNEGEADIVVNHVISLI 671
P V T T+ PLLL+DT GC L+ + S N GE +V H+ +L+
Sbjct: 474 LPGVTDTEETRVPLLLIDT--------AGCGLLELEEEDSQSKGNPGEVRLVTLHIQALV 525
Query: 670 YAGVSQMAIAVQSPYVAQVQLPRERLDEFPVADGVEVATIDSFQGREANAVIISMVRSNN 491
AGV IAV +PY QV L R+ L +E+ ++D FQGRE AV+++ VRSN
Sbjct: 526 DAGVQAGDIAVIAPYNLQVDLLRQSLSN--KHPELEIKSVDGFQGREKEAVLLTFVRSNR 583
Query: 490 LGAVGFLGDSRRMNVAITRARKHVAVVCDSSTICHNTFLARLLRHIRYFGRVKHA 326
G VGFL + RR+NVA+TRAR+HVAV+CDS T+ ++ FL L+ + G V+ A
Sbjct: 584 KGEVGFLAEDRRINVAVTRARRHVAVICDSHTVNNHAFLETLVDYFTEHGEVRTA 638
>sp|Q09820|RENT1_SCHPO Regulator of nonsense transcripts 1 homolog
OS=Schizosaccharomyces pombe GN=SPAC16C9.06c PE=2 SV=2
Length = 925
Score = 180 bits (456), Expect = 5e-044
Identities = 160/489 (32%), Positives = 238/489 (48%), Gaps = 64/489 (13%)
Frame = -3
Query: 1681 SQRRAIALGVNKKRPVMIVQGPPGTGKTGMLKEVI-TLAVQQGER------VLVTAPTNA 1523
SQ A+ ++K P+ ++QGPPGTGKT V+ LA Q + VLV AP+N
Sbjct: 396 SQSEAVRAVLSK--PLSLIQGPPGTGKTVTSASVVYHLATMQSRKRKSHSPVLVCAPSNV 453
Query: 1522 AVDNMVEKLSHLGLNIVRVGNPAR--ISSAVASKSLGEIVNSKLASFRAELERKKSDLRK 1349
AVD + EK+ GL +VRV +R I S+V+ SL E + K F EL+R
Sbjct: 454 AVDQLAEKIHRTGLRVVRVAAKSREDIESSVSFLSLHEQI--KNYKFNPELQRLLK---- 507
Query: 1348 DLRQCLRDDSLATGIRQLLKQLGKTLKKKEKETVKEILSNAQVVFATNIGSADPLIRMLD 1169
LR ++ +L Q K L+ KE+L A V+ T +G+ D I
Sbjct: 508 -----LRSEN-----NELSIQDEKKLRILVAAAEKELLRAAHVICCTCVGAGDRRISKY- 556
Query: 1168 TFDLVVIDEAGQSIEPSCWIPILQG-KRCILAGDPCQLAPVVLSRKALEDGLGVSLLERA 992
F V+IDEA Q+ EP C IP++ G K+ +L GD QL PVV+++K L SL ER
Sbjct: 557 KFRSVLIDEATQASEPECMIPLVLGAKQVVLVGDHQQLGPVVMNKKVALASLSQSLFERL 616
Query: 991 ASLHDGLLATKLSTQYRMNDVIAGWASKEMYGGWLK----SSPSVASHLLIDSPFVKPTW 824
L G +L QYRM+ ++ + S Y G L+ +S +A H +D P+++P
Sbjct: 617 IIL--GNSPFRLVVQYRMHPCLSEFPSNTFYEGTLQNGVTTSERIARH--VDFPWIQP-- 670
Query: 823 ITQCPLLLLDTRMPYGSLSVGCEERLDPAGTGSLYNEGEADIVVNHVISLIYAGVSQMAI 644
PL+ Y + +E L +GT S N EA V + + + V I
Sbjct: 671 --DSPLMF------YANFG---QEELSASGT-SFLNRTEASTCEKIVTTFLRSNVLPEQI 718
Query: 643 AVQSPYVAQVQLPRERLDEFPVADG---------VEVATIDSFQGREANAVIISMVRSNN 491
+ +PY Q R + ++ +G VEVA++D+FQGRE + +I+S VRS+
Sbjct: 719 GIVTPYDGQ----RSYIVQYMQNNGSMQKDLYKAVEVASVDAFQGREKDFIILSCVRSSE 774
Query: 490 LGAVGFLGDSRRMNVAITRARKHVAVVCDSSTICHNTFLARLLRHIRYFGRVKHADPGSL 311
+GF+ D RR+NVA+TRA+ V V+ + + + + H + G + SL
Sbjct: 775 HQGIGFVNDPRRLNVALTRAKYGVIVLGNPKVLAKHALWYHFVLHCKEKGYLVEGTLNSL 834
Query: 310 GGSGLGLDP 284
L L P
Sbjct: 835 QKFSLTLTP 843
>sp|O94247|HCS1_SCHPO DNA polymerase alpha-associated DNA helicase A
OS=Schizosaccharomyces pombe GN=hcs1 PE=2 SV=1
Length = 660
Score = 158 bits (399), Expect = 2e-037
Identities = 103/308 (33%), Positives = 169/308 (54%), Gaps = 19/308 (6%)
Frame = -3
Query: 1696 KLFDDSQRRAIALGVNKKRPVMIVQGPPGTGKTGMLKEVITLAVQQGERVLVTAPTNAAV 1517
K + SQ++A+ + K + ++ GPPGTGKT L E+I V + +R+LV +N AV
Sbjct: 208 KELNASQKKAVKFSIAVKE-LSLIHGPPGTGKTHTLVEIIQQLVLRNKRILVCGASNLAV 266
Query: 1516 DNMVEKLSHLGLNIVRVGNPARISSAVASKSLGEIVNSKLASFRAELERKKSDLRKDLRQ 1337
DN+V++LS G+ +VR+G+PAR+ ++ SL + + ++ R + +D+
Sbjct: 267 DNIVDRLSSSGIPMVRLGHPARLLPSILDHSLDVLSRT---GDNGDVIR---GISEDIDV 320
Query: 1336 CL------RDDSLATGIRQLLKQLGKTLKKKEKETVKEILSNAQVVFATNIGSADPLIRM 1175
CL ++ I + +++L K +K E +TV I+S ++VVF T G+ ++
Sbjct: 321 CLSKITKTKNGRERREIYKNIRELRKDYRKYEAKTVANIVSASKVVFCTLHGAGSRQLKG 380
Query: 1174 LDTFDLVVIDEAGQSIEPSCWIPILQGKRCILAGDPCQLAPVVLSRKALEDGLGVSLLER 995
FD V+IDEA Q++EP CWIP+L + ILAGD QL+P V S++ +S+ ER
Sbjct: 381 -QRFDAVIIDEASQALEPQCWIPLLGMNKVILAGDHMQLSPNVQSKRPY-----ISMFER 434
Query: 994 AASLHDGLLATKLSTQYRMNDVIAGWASKEMYGGWLKSSPSVASHLLIDSPFVKPTWITQ 815
L+ L+ QYRM+++I+ + S Y L + V LL+D V+ T +T
Sbjct: 435 LVKSQGDLVKCFLNIQYRMHELISKFPSDTFYDSKLVPAEEVKKRLLMDLENVEETELTD 494
Query: 814 CPLLLLDT 791
P+ DT
Sbjct: 495 SPIYFYDT 502
Score = 97 bits (240), Expect = 5e-019
Identities = 52/109 (47%), Positives = 73/109 (66%), Gaps = 2/109 (1%)
Frame = -3
Query: 718 NEGEADIVVNHVISLIYAGVSQMAIAVQSPYVAQVQLPRERLDEFPVADGVEVATIDSFQ 539
N EA IV H+ L+ AG+ IAV +PY AQV L R+ L E + VE+ ++D Q
Sbjct: 525 NHWEAQIVSYHISGLLEAGLEAKDIAVVTPYNAQVALIRQLLKEKGIE--VEMGSVDKVQ 582
Query: 538 GREANAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAVVCDSSTI 392
GRE A+I S+VRSN++ VGFL + RR+NVAITR ++H+ V+ DS+T+
Sbjct: 583 GREKEAIIFSLVRSNDVREVGFLAEKRRLNVAITRPKRHLCVIGDSNTV 631
>sp|P34243|HCS1_YEAST DNA polymerase alpha-associated DNA helicase A
OS=Saccharomyces cerevisiae GN=HCS1 PE=1 SV=1
Length = 683
Score = 93 bits (230), Expect = 8e-018
Identities = 54/122 (44%), Positives = 78/122 (63%), Gaps = 4/122 (3%)
Frame = -3
Query: 730 GSLYNEGEADIVVNHVISLIYAGVSQMAIAVQSPYVAQVQLPRERL-DEFPVADGVEVAT 554
GS YNEGE IV H+ +L V + +I V SPY AQV ++ + DE + D +E++T
Sbjct: 541 GSKYNEGEIAIVKEHIENLRSFNVPENSIGVISPYNAQVSHLKKLIHDELKLTD-IEIST 599
Query: 553 IDSFQGREANAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAVVCDSSTI--CHNT 380
+D FQGRE + +I+S+VRSN VGFL + RR+NVA+TR R+ + VV + + C N
Sbjct: 600 VDGFQGREKDVIILSLVRSNEKFEVGFLKEERRLNVAMTRPRRQLVVVGNIEVLQRCGNK 659
Query: 379 FL 374
+L
Sbjct: 660 YL 661
>sp|O76512|RENT1_CAEEL Regulator of nonsense transcripts 1 OS=Caenorhabditis
elegans GN=smg-2 PE=1 SV=1
Length = 1069
Score = 77 bits (188), Expect = 6e-013
Identities = 49/140 (35%), Positives = 76/140 (54%), Gaps = 6/140 (4%)
Frame = -3
Query: 754 ERLDPAGTGSLYNEGEADIVVNHVISLIYAGVSQMAIAVQSPYVAQVQ-----LPRERLD 590
E L +GT S N EA V V LI AGV I V + Y Q + +
Sbjct: 729 EELSASGT-SFLNRTEAANVEKLVSKLIKAGVQPHQIGVITSYEGQRSFIVNYMHTQGTL 787
Query: 589 EFPVADGVEVATIDSFQGREANAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAVV 410
+ + VE+A++D+FQGRE + +I++ VRSN++ +GFL D RR+NVAITRA+ + +V
Sbjct: 788 NSKLYENVEIASVDAFQGREKDYIIVTCVRSNDILGIGFLSDPRRLNVAITRAKYGLVLV 847
Query: 409 CDSSTICHNTFLARLLRHIR 350
++ + + L+ H +
Sbjct: 848 GNAKVLARHDLWHELINHYK 867
>sp|Q9HEH1|RENT1_NEUCR Regulator of nonsense transcripts 1 homolog OS=Neurospora
crassa GN=2E4.130 PE=3 SV=1
Length = 1093
Score = 75 bits (183), Expect = 2e-012
Identities = 49/140 (35%), Positives = 72/140 (51%), Gaps = 6/140 (4%)
Frame = -3
Query: 754 ERLDPAGTGSLYNEGEADIVVNHVISLIYAGVSQMAIAVQSPYVAQ---VQLPRERLDEF 584
E + +GT S N EA V V AGV I V +PY Q + + F
Sbjct: 740 EEISASGT-SYLNRTEAANVEKIVTRFFKAGVKPADIGVITPYEGQRSYIVNTMQNTGTF 798
Query: 583 PVAD--GVEVATIDSFQGREANAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAVV 410
VEVA++D+FQGRE + +++S VRSN +GFL D RR+NVA+TRA+ + ++
Sbjct: 799 KKESYREVEVASVDAFQGREKDFIVLSCVRSNENQGIGFLSDPRRLNVALTRAKYGLVII 858
Query: 409 CDSSTICHNTFLARLLRHIR 350
+ +C + LL H +
Sbjct: 859 GNPKVLCKHELWHHLLVHFK 878
>sp|Q9FJR0|RENT1_ARATH Regulator of nonsense transcripts 1 homolog
OS=Arabidopsis thaliana GN=UPF1 PE=1 SV=2
Length = 1254
Score = 74 bits (181), Expect = 4e-012
Identities = 49/141 (34%), Positives = 73/141 (51%), Gaps = 6/141 (4%)
Frame = -3
Query: 757 EERLDPAGTGSLYNEGEADIVVNHVISLIYAGVSQMAIAVQSPYVAQ-----VQLPRERL 593
+E + +GT S N EA V V + + +GV I V +PY Q + R
Sbjct: 774 QEEISASGT-SYLNRTEAANVEKLVTAFLKSGVVPSQIGVITPYEGQRAYIVNYMARNGS 832
Query: 592 DEFPVADGVEVATIDSFQGREANAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAV 413
+ +EVA++DSFQGRE + +I+S VRSN +GFL D RR+NVA+TRAR + +
Sbjct: 833 LRQQLYKEIEVASVDSFQGREKDYIILSCVRSNEHQGIGFLNDPRRLNVALTRARYGIVI 892
Query: 412 VCDSSTICHNTFLARLLRHIR 350
+ + + LL H +
Sbjct: 893 LGNPKVLSKQPLWNGLLTHYK 913
>sp|P30771|NAM7_YEAST ATP-dependent helicase NAM7 OS=Saccharomyces cerevisiae
GN=NAM7 PE=1 SV=1
Length = 971
Score = 72 bits (176), Expect = 1e-011
Identities = 51/144 (35%), Positives = 74/144 (51%), Gaps = 8/144 (5%)
Frame = -3
Query: 754 ERLDPAGTGSLYNEGEADIVVNHVISLIYAGVSQMAIAVQSP------YVAQVQLPRERL 593
E + GT S N EA + L GV I V +P Y+ Q L
Sbjct: 691 EEISANGT-SFLNRIEAMNCERIITKLFRDGVKPEQIGVITPYEGQRAYILQYMQMNGSL 749
Query: 592 DEFPVADGVEVATIDSFQGREANAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAV 413
D+ + VEVA++D+FQGRE + +I+S VR+N A+GFL D RR+NV +TRA+ + +
Sbjct: 750 DK-DLYIKVEVASVDAFQGREKDYIILSCVRANEQQAIGFLRDPRRLNVGLTRAKYGLVI 808
Query: 412 VCDSSTICHNTFLARLLRHIRYFG 341
+ + ++ NT LL H R G
Sbjct: 809 LGNPRSLARNTLWNHLLIHFREKG 832
>sp|Q54I89|RENT1_DICDI Regulator of nonsense transcripts 1 OS=Dictyostelium
discoideum GN=upf1 PE=3 SV=1
Length = 1331
Score = 72 bits (176), Expect = 1e-011
Identities = 45/140 (32%), Positives = 72/140 (51%), Gaps = 6/140 (4%)
Frame = -3
Query: 754 ERLDPAGTGSLYNEGEADIVVNHVISLIYAGVSQMAIAVQSPYVAQVQLPRERLDE---- 587
E + +GT S N EA I V + G I + +PY Q + +
Sbjct: 824 EEISSSGT-SFINTTEASICEKIVTKFLELGSLPGQIGIITPYEGQRAYITSHMQKSGKL 882
Query: 586 -FPVADGVEVATIDSFQGREANAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAVV 410
+ +EVA++DSFQGRE + +I+S VRSN+ +GFL D RR+NVA+TRAR + ++
Sbjct: 883 NLELYKSIEVASVDSFQGREKDYIILSCVRSNDYQGIGFLQDPRRLNVALTRARFGLIIL 942
Query: 409 CDSSTICHNTFLARLLRHIR 350
++ + + L+ H +
Sbjct: 943 GNAKVLSKDPLWNSLISHFK 962
>sp|Q92900|RENT1_HUMAN Regulator of nonsense transcripts 1 OS=Homo sapiens
GN=UPF1 PE=1 SV=2
Length = 1129
Score = 70 bits (170), Expect = 7e-011
Identities = 46/141 (32%), Positives = 71/141 (50%), Gaps = 6/141 (4%)
Frame = -3
Query: 757 EERLDPAGTGSLYNEGEADIVVNHVISLIYAGVSQMAIAVQSPYVAQVQLPRERLD---- 590
+E + +GT S N EA V L+ AG I + +PY Q + +
Sbjct: 765 QEEIASSGT-SYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGS 823
Query: 589 -EFPVADGVEVATIDSFQGREANAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAV 413
+ VE+A++D+FQGRE + +I+S VR+N +GFL D RR+NVA+TRAR V +
Sbjct: 824 LHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVII 883
Query: 412 VCDSSTICHNTFLARLLRHIR 350
V + + LL + +
Sbjct: 884 VGNPKALSKQPLWNHLLNYYK 904
>sp|Q9EPU0|RENT1_MOUSE Regulator of nonsense transcripts 1 OS=Mus musculus
GN=Upf1 PE=1 SV=2
Length = 1124
Score = 70 bits (169), Expect = 9e-011
Identities = 46/141 (32%), Positives = 71/141 (50%), Gaps = 6/141 (4%)
Frame = -3
Query: 757 EERLDPAGTGSLYNEGEADIVVNHVISLIYAGVSQMAIAVQSPYVAQVQLPRERLD---- 590
+E + +GT S N EA V L+ AG I + +PY Q + +
Sbjct: 760 QEEIASSGT-SYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGS 818
Query: 589 -EFPVADGVEVATIDSFQGREANAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAV 413
+ VE+A++D+FQGRE + +I+S VR+N +GFL D RR+NVA+TRAR V +
Sbjct: 819 LHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVII 878
Query: 412 VCDSSTICHNTFLARLLRHIR 350
V + + LL + +
Sbjct: 879 VGNPKALSKQPLWNHLLSYYK 899
>sp|Q98TR3|RENT1_TAKRU Putative regulator of nonsense transcripts 1 OS=Takifugu
rubripes GN=rent1 PE=3 SV=1
Length = 1097
Score = 69 bits (166), Expect = 2e-010
Identities = 47/140 (33%), Positives = 71/140 (50%), Gaps = 5/140 (3%)
Frame = -3
Query: 757 EERLDPAGTGSLYNEGEADIVVNHVISLIYAGVSQMAIAVQSPYVAQ----VQLPRERLD 590
+E + +GT S N EA V L+ AG I + +PY Q VQ +
Sbjct: 735 QEEIASSGT-SYLNRTEAANVEKITTRLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGS 793
Query: 589 EFPVADGVEVATIDSFQGREANAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAVV 410
VE+A++D+FQGRE + +I+S VR+N +GFL D RR+NVA+TRA+ V +V
Sbjct: 794 LHTKLYQVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRAKYGVIIV 853
Query: 409 CDSSTICHNTFLARLLRHIR 350
+ + LL + +
Sbjct: 854 GNPKALSKQPLWNNLLNNYK 873
>sp|Q9VYS3|RENT1_DROME Regulator of nonsense transcripts 1 homolog OS=Drosophila
melanogaster GN=Upf1 PE=1 SV=2
Length = 1180
Score = 67 bits (163), Expect = 5e-010
Identities = 45/137 (32%), Positives = 71/137 (51%), Gaps = 6/137 (4%)
Frame = -3
Query: 757 EERLDPAGTGSLYNEGEADIVVNHVISLIYAGVSQMAIAVQSPYVAQ----VQ-LPRERL 593
+E + +GT S N EA V + AG+ I + +PY Q VQ + +
Sbjct: 734 QEEIAGSGT-SFLNRTEAANVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGS 792
Query: 592 DEFPVADGVEVATIDSFQGREANAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAV 413
+ +E+A++D+FQGRE + +I+S VRSN +GFL D RR+NVA+TRA+ + +
Sbjct: 793 LHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIII 852
Query: 412 VCDSSTICHNTFLARLL 362
V + + LL
Sbjct: 853 VGNPKVLAKQQLWNHLL 869
>sp|P32644|ECM32_YEAST Putative ATP-dependent RNA helicase ECM32
OS=Saccharomyces cerevisiae GN=ECM32 PE=1 SV=1
Length = 1121
Score = 63 bits (151), Expect = 1e-008
Identities = 29/63 (46%), Positives = 44/63 (69%)
Frame = -3
Query: 580 VADGVEVATIDSFQGREANAVIISMVRSNNLGAVGFLGDSRRMNVAITRARKHVAVVCDS 401
+ +G+ VAT+DSFQG E + +I S VR+N +GFL D RR+NVA+TRA+ + VV +
Sbjct: 1032 IINGLHVATVDSFQGHEKSFIIFSCVRNNTENKIGFLRDKRRLNVALTRAKHGLIVVGNK 1091
Query: 400 STI 392
+ +
Sbjct: 1092 NVL 1094
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,924,390,942
Number of Sequences: 518415
Number of Extensions: 86924390942
Number of Successful Extensions: 587655121
Number of sequences better than 0.0: 0
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