BLASTX 7.6.2
Query= UN21002 /QuerySize=2027
(2026 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P40961|PHB1_YEAST Prohibitin-1 OS=Saccharomyces cerevisiae GN... 302 1e-080
sp|Q54GI9|PHB1_DICDI Prohibitin-1, mitochondrial OS=Dictyosteliu... 300 3e-080
sp|Q3T165|PHB_BOVIN Prohibitin OS=Bos taurus GN=PHB PE=2 SV=1 297 2e-079
sp|P35232|PHB_HUMAN Prohibitin OS=Homo sapiens GN=PHB PE=1 SV=1 297 2e-079
sp|Q9P7H3|PHB1_SCHPO Prohibitin-1 OS=Schizosaccharomyces pombe G... 297 3e-079
sp|P84173|PHB_CHICK Prohibitin OS=Gallus gallus GN=PHB PE=1 SV=1 296 4e-079
sp|P67778|PHB_MOUSE Prohibitin OS=Mus musculus GN=Phb PE=1 SV=1 296 4e-079
sp|P67779|PHB_RAT Prohibitin OS=Rattus norvegicus GN=Phb PE=1 SV=1 296 4e-079
sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex protein 1 ... 289 9e-077
sp|P24156|L2CC_DROME Protein l(2)37Cc OS=Drosophila melanogaster... 287 2e-076
sp|Q54Q31|PHB2_DICDI Prohibitin-2 OS=Dictyostelium discoideum GN... 285 1e-075
sp|P50085|PHB2_YEAST Prohibitin-2 OS=Saccharomyces cerevisiae GN... 268 1e-070
sp|A9UMS3|PHB2_XENTR Prohibitin-2 OS=Xenopus tropicalis GN=phb2 ... 262 1e-068
sp|Q5RB19|PHB2_PONAB Prohibitin-2 OS=Pongo abelii GN=PHB2 PE=2 SV=1 259 6e-068
sp|Q2HJ97|PHB2_BOVIN Prohibitin-2 OS=Bos taurus GN=PHB2 PE=2 SV=1 258 1e-067
sp|Q99623|PHB2_HUMAN Prohibitin-2 OS=Homo sapiens GN=PHB2 PE=1 SV=2 258 1e-067
sp|O35129|PHB2_MOUSE Prohibitin-2 OS=Mus musculus GN=Phb2 PE=1 SV=1 258 1e-067
sp|Q5XIH7|PHB2_RAT Prohibitin-2 OS=Rattus norvegicus GN=Phb2 PE=... 258 1e-067
sp|O94550|PHB2_SCHPO Prohibitin-2 OS=Schizosaccharomyces pombe G... 253 4e-066
sp|Q5ZMN3|PHB2_CHICK Prohibitin-2 OS=Gallus gallus GN=PHB2 PE=2 ... 252 1e-065
>sp|P40961|PHB1_YEAST Prohibitin-1 OS=Saccharomyces cerevisiae GN=PHB1 PE=1
SV=2
Length = 287
Score = 302 bits (771), Expect = 1e-080
Identities = 149/257 (57%), Positives = 202/257 (78%)
Frame = -3
Query: 1061 LAKAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPILQRPHIFD 882
+ K A +G+ A+ + S+Y V GG R V+FDR GV Q VGEGTHFL+P LQ+ I+D
Sbjct: 11 ITKVALPIGIIASGIQYSMYDVKGGSRGVIFDRINGVKQQVVGEGTHFLVPWLQKAIIYD 70
Query: 881 IRTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPSIGNEVLK 702
+RTKP + ++ +GTKDLQMV+LTLRVL RPEV + P I+Q LGL+YDE+VLPSIGNEVLK
Sbjct: 71 VRTKPKSIATNTGTKDLQMVSLTLRVLHRPEVLQLPAIYQNLGLDYDERVLPSIGNEVLK 130
Query: 701 AVVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSRAVEAKQV 522
++VAQF+A +L+T+R +S +R L RA +F I+L+DV+ITH+++G EF++AVE KQ+
Sbjct: 131 SIVAQFDAAELITQREIISQKIRKELSTRANEFGIKLEDVSITHMTFGPEFTKAVEQKQI 190
Query: 521 AQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVA 342
AQQ+AER+KF+V KA+QER+A+VIRAEGE+E+A+ IS A AK G GL+ +RR+EAS+++A
Sbjct: 191 AQQDAERAKFLVEKAEQERQASVIRAEGEAESAEFISKALAKVGDGLLLIRRLEASKDIA 250
Query: 341 ATLARSPNVAYLPGGQS 291
TLA S NV YLP S
Sbjct: 251 QTLANSSNVVYLPSQHS 267
>sp|Q54GI9|PHB1_DICDI Prohibitin-1, mitochondrial OS=Dictyostelium discoideum
GN=phbA PE=3 SV=1
Length = 271
Score = 300 bits (767), Expect = 3e-080
Identities = 148/268 (55%), Positives = 207/268 (77%), Gaps = 1/268 (0%)
Frame = -3
Query: 1076 SFLTNLAKAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPILQR 897
SFL L A +G ++ SS+YTVDGG+RAV+FDR GV +++VGEGTHF++P LQ+
Sbjct: 3 SFLNKLIPLALTVGTGLSLAQSSMYTVDGGQRAVIFDRISGVKEKSVGEGTHFIMPWLQK 62
Query: 896 PHIFDIRTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPSIG 717
P IFDIR+ P S +G+KDLQ V++T+RVL RP+V P+IF LGL+YDE++LPS+G
Sbjct: 63 PIIFDIRSSPRNIKSDTGSKDLQTVSVTVRVLFRPDVEHLPSIFSKLGLDYDERILPSLG 122
Query: 716 NEVLKAVVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSRAV 537
NEVLK+VVAQ++A +L+T+R VS +R+SL+KRA++FN+ LDDV+ITHLS+ +F+ A+
Sbjct: 123 NEVLKSVVAQYDATELITQREVVSKEIRESLMKRAKEFNLLLDDVSITHLSFSQDFTNAI 182
Query: 536 EAKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEA 357
E KQVAQQEAERSK++VMK +QE++A +IRAEGE+EAA+LI A + IELRRIEA
Sbjct: 183 EHKQVAQQEAERSKYIVMKNEQEKKANIIRAEGEAEAAKLIGQAMGNSA-AFIELRRIEA 241
Query: 356 SREVAATLARSPNVAYLPGGQSMLFNLN 273
+++ +L++S V Y+P ++L NLN
Sbjct: 242 YKDITESLSKSKQVTYVPTSGNLLMNLN 269
>sp|Q3T165|PHB_BOVIN Prohibitin OS=Bos taurus GN=PHB PE=2 SV=1
Length = 272
Score = 297 bits (760), Expect = 2e-079
Identities = 149/269 (55%), Positives = 205/269 (76%)
Frame = -3
Query: 1082 AVSFLTNLAKAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPIL 903
A ++ K L V+ V++S+LY VD G RAV+FDRFRGV D VGEGTHFLIP +
Sbjct: 2 AAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWV 61
Query: 902 QRPHIFDIRTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPS 723
Q+P IFD R++P ++G+KDLQ VN+TLR+L RP S+ P IF ++G +YDE+VLPS
Sbjct: 62 QKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPS 121
Query: 722 IGNEVLKAVVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSR 543
I E+LK+VVA+F+A +L+T+R VS V D L +RA F + LDDV++THL++G EF+
Sbjct: 122 ITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTE 181
Query: 542 AVEAKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRI 363
AVEAKQVAQQEAER++FVV KA+Q+++AA+I AEG+S+AA+LI+++ A AG GLIELR++
Sbjct: 182 AVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKL 241
Query: 362 EASREVAATLARSPNVAYLPGGQSMLFNL 276
EA+ ++A L+RS N+ YLP GQS+L L
Sbjct: 242 EAAEDIAYQLSRSRNITYLPAGQSVLLQL 270
>sp|P35232|PHB_HUMAN Prohibitin OS=Homo sapiens GN=PHB PE=1 SV=1
Length = 272
Score = 297 bits (760), Expect = 2e-079
Identities = 149/269 (55%), Positives = 205/269 (76%)
Frame = -3
Query: 1082 AVSFLTNLAKAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPIL 903
A ++ K L V+ V++S+LY VD G RAV+FDRFRGV D VGEGTHFLIP +
Sbjct: 2 AAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWV 61
Query: 902 QRPHIFDIRTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPS 723
Q+P IFD R++P ++G+KDLQ VN+TLR+L RP S+ P IF ++G +YDE+VLPS
Sbjct: 62 QKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPS 121
Query: 722 IGNEVLKAVVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSR 543
I E+LK+VVA+F+A +L+T+R VS V D L +RA F + LDDV++THL++G EF+
Sbjct: 122 ITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTE 181
Query: 542 AVEAKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRI 363
AVEAKQVAQQEAER++FVV KA+Q+++AA+I AEG+S+AA+LI+++ A AG GLIELR++
Sbjct: 182 AVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKL 241
Query: 362 EASREVAATLARSPNVAYLPGGQSMLFNL 276
EA+ ++A L+RS N+ YLP GQS+L L
Sbjct: 242 EAAEDIAYQLSRSRNITYLPAGQSVLLQL 270
>sp|Q9P7H3|PHB1_SCHPO Prohibitin-1 OS=Schizosaccharomyces pombe GN=phb1 PE=2
SV=1
Length = 282
Score = 297 bits (758), Expect = 3e-079
Identities = 149/259 (57%), Positives = 202/259 (77%), Gaps = 1/259 (0%)
Frame = -3
Query: 1070 LTNLAKAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPILQRPH 891
L +A+ A +G+ T+L SS+Y V GG+RAVLFDR GV Q V EGTHFLIP LQ+
Sbjct: 5 LERVARYAIPIGIGFTLLQSSIYDVPGGKRAVLFDRLSGVQKQVVQEGTHFLIPWLQKAI 64
Query: 890 IFDIRTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPSIGNE 711
++D+RT+P ++ +G+KDLQMV+LTLRVL RPEV P I+Q LGL+YDE+VLPSIGNE
Sbjct: 65 VYDVRTRPRNIATTTGSKDLQMVSLTLRVLHRPEVGMLPQIYQNLGLDYDERVLPSIGNE 124
Query: 710 VLKAVVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSRAVEA 531
+LK+VVAQF+A +L+T+R VSA +R L++RA +F I L+DV+ITH+++G EF++AVE
Sbjct: 125 ILKSVVAQFDAAELITQREVVSAKIRQELVQRATEFGIRLEDVSITHMTFGKEFTKAVER 184
Query: 530 KQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASR 351
KQ+AQQEAER++F+V +++QER+A VIRAEGE+EAA ++S A KAG LI++RR+E S+
Sbjct: 185 KQIAQQEAERARFLVEQSEQERQANVIRAEGEAEAADIVSKALDKAGGALIQIRRLETSK 244
Query: 350 EVAATLA-RSPNVAYLPGG 297
EVA LA + V YLP G
Sbjct: 245 EVATALANKGAQVTYLPFG 263
>sp|P84173|PHB_CHICK Prohibitin OS=Gallus gallus GN=PHB PE=1 SV=1
Length = 272
Score = 296 bits (757), Expect = 4e-079
Identities = 147/269 (54%), Positives = 205/269 (76%)
Frame = -3
Query: 1082 AVSFLTNLAKAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPIL 903
A ++ K GL V+ V++S+LY VD G RAV+FDRFRGV D VGEGTHFLIP +
Sbjct: 2 AAKVFESIGKFGLGLAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDTVVGEGTHFLIPWV 61
Query: 902 QRPHIFDIRTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPS 723
Q+P IFD R++P ++G+KDLQ VN+TLR+L RP ++ P IF ++G +YDE+VLPS
Sbjct: 62 QKPIIFDCRSRPRNIPVITGSKDLQNVNITLRILFRPVTAQLPRIFTSIGEDYDERVLPS 121
Query: 722 IGNEVLKAVVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSR 543
I E+LK+VVA+F+A +L+T+R VS V + L +RA F + LDDV++THL++G EF+
Sbjct: 122 ITTEILKSVVARFDAGELITQRELVSRQVSEDLTERAATFGLILDDVSLTHLTFGKEFTE 181
Query: 542 AVEAKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRI 363
AVE KQVAQQEAER++F+V KA+Q+++AAVI AEG+S+AA+LI+++ A AG GLIELR++
Sbjct: 182 AVEMKQVAQQEAERARFIVEKAEQQKKAAVISAEGDSKAAELIANSLATAGDGLIELRKL 241
Query: 362 EASREVAATLARSPNVAYLPGGQSMLFNL 276
EA+ ++A L+RS N+ YLP GQS+L L
Sbjct: 242 EAAEDIAYQLSRSRNITYLPSGQSVLLQL 270
>sp|P67778|PHB_MOUSE Prohibitin OS=Mus musculus GN=Phb PE=1 SV=1
Length = 272
Score = 296 bits (757), Expect = 4e-079
Identities = 148/269 (55%), Positives = 205/269 (76%)
Frame = -3
Query: 1082 AVSFLTNLAKAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPIL 903
A ++ K L V+ V++S+LY VD G RAV+FDRFRGV D VGEGTHFLIP +
Sbjct: 2 AAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWV 61
Query: 902 QRPHIFDIRTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPS 723
Q+P IFD R++P ++G+KDLQ VN+TLR+L RP S+ P I+ ++G +YDE+VLPS
Sbjct: 62 QKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLPS 121
Query: 722 IGNEVLKAVVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSR 543
I E+LK+VVA+F+A +L+T+R VS V D L +RA F + LDDV++THL++G EF+
Sbjct: 122 ITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTE 181
Query: 542 AVEAKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRI 363
AVEAKQVAQQEAER++FVV KA+Q+++AA+I AEG+S+AA+LI+++ A AG GLIELR++
Sbjct: 182 AVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKL 241
Query: 362 EASREVAATLARSPNVAYLPGGQSMLFNL 276
EA+ ++A L+RS N+ YLP GQS+L L
Sbjct: 242 EAAEDIAYQLSRSRNITYLPAGQSVLLQL 270
>sp|P67779|PHB_RAT Prohibitin OS=Rattus norvegicus GN=Phb PE=1 SV=1
Length = 272
Score = 296 bits (757), Expect = 4e-079
Identities = 148/269 (55%), Positives = 205/269 (76%)
Frame = -3
Query: 1082 AVSFLTNLAKAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPIL 903
A ++ K L V+ V++S+LY VD G RAV+FDRFRGV D VGEGTHFLIP +
Sbjct: 2 AAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWV 61
Query: 902 QRPHIFDIRTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPS 723
Q+P IFD R++P ++G+KDLQ VN+TLR+L RP S+ P I+ ++G +YDE+VLPS
Sbjct: 62 QKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLPS 121
Query: 722 IGNEVLKAVVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSR 543
I E+LK+VVA+F+A +L+T+R VS V D L +RA F + LDDV++THL++G EF+
Sbjct: 122 ITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTE 181
Query: 542 AVEAKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRI 363
AVEAKQVAQQEAER++FVV KA+Q+++AA+I AEG+S+AA+LI+++ A AG GLIELR++
Sbjct: 182 AVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKL 241
Query: 362 EASREVAATLARSPNVAYLPGGQSMLFNL 276
EA+ ++A L+RS N+ YLP GQS+L L
Sbjct: 242 EAAEDIAYQLSRSRNITYLPAGQSVLLQL 270
>sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex protein 1
OS=Caenorhabditis elegans GN=phb-1 PE=1 SV=1
Length = 275
Score = 289 bits (737), Expect = 9e-077
Identities = 144/272 (52%), Positives = 201/272 (73%)
Frame = -3
Query: 1085 AAVSFLTNLAKAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPI 906
+A L L GL ++ + ++LY VDGG+RAV+FDRF GV ++ VGEGTHFLIP
Sbjct: 4 SAQKLLGRLGTVGVGLSIAGGIAQTALYNVDGGQRAVIFDRFSGVKNEVVGEGTHFLIPW 63
Query: 905 LQRPHIFDIRTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLP 726
+Q+P IFDIR+ P ++++G+KDLQ VN+TLR+L RP R P I+ +GL+Y E+VLP
Sbjct: 64 VQKPIIFDIRSTPRAVTTITGSKDLQNVNITLRILHRPSPDRLPNIYLNIGLDYAERVLP 123
Query: 725 SIGNEVLKAVVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFS 546
SI NEVLKAVVAQF+A +++T+R VS +L +RA F + LDD+AITHL++G EF+
Sbjct: 124 SITNEVLKAVVAQFDAHEMITQREVVSQRASVALRERAAQFGLLLDDIAITHLNFGREFT 183
Query: 545 RAVEAKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRR 366
AVE KQVAQQEAE+++++V KA+Q + AAV AEG+++AA+L++ A A AG GL+ELR+
Sbjct: 184 EAVEMKQVAQQEAEKARYLVEKAEQMKIAAVTTAEGDAQAAKLLAKAFASAGDGLVELRK 243
Query: 365 IEASREVAATLARSPNVAYLPGGQSMLFNLNA 270
IEA+ E+A +A++ NV YLPG Q L NL +
Sbjct: 244 IEAAEEIAERMAKNKNVTYLPGNQQTLLNLQS 275
>sp|P24156|L2CC_DROME Protein l(2)37Cc OS=Drosophila melanogaster GN=l(2)37Cc
PE=1 SV=2
Length = 276
Score = 287 bits (734), Expect = 2e-076
Identities = 145/269 (53%), Positives = 197/269 (73%)
Frame = -3
Query: 1082 AVSFLTNLAKAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPIL 903
A F + + G+ V V++S+LY V+GG RAV+FDRF G+ + VGEGTHF IP +
Sbjct: 2 AAQFFNRIGQMGLGVAVLGGVVNSALYNVEGGHRAVIFDRFTGIKENVVGEGTHFFIPWV 61
Query: 902 QRPHIFDIRTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPS 723
QRP IFDIR++P ++G+KDLQ VN+TLR+L RP + P I+ LG +YDE+VLPS
Sbjct: 62 QRPIIFDIRSQPRNVPVITGSKDLQNVNITLRILYRPIPDQLPKIYTILGQDYDERVLPS 121
Query: 722 IGNEVLKAVVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSR 543
I EVLKAVVAQF+A +L+T+R VS V L RA+ F LDD+++THL++G EF+
Sbjct: 122 IAPEVLKAVVAQFDAGELITQREMVSQRVSQELTVRAKQFGFILDDISLTHLTFGREFTL 181
Query: 542 AVEAKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRI 363
AVE KQVAQQEAE+++FVV KA+Q++ A++I AEG++EAA L++ + +AG GL+ELRRI
Sbjct: 182 AVEMKQVAQQEAEKARFVVEKAEQQKLASIISAEGDAEAAGLLAKSFGEAGDGLVELRRI 241
Query: 362 EASREVAATLARSPNVAYLPGGQSMLFNL 276
EA+ ++A L+RS VAYLP GQS L NL
Sbjct: 242 EAAEDIAYQLSRSRGVAYLPSGQSTLLNL 270
>sp|Q54Q31|PHB2_DICDI Prohibitin-2 OS=Dictyostelium discoideum GN=phbB PE=3
SV=1
Length = 293
Score = 285 bits (727), Expect = 1e-075
Identities = 144/275 (52%), Positives = 208/275 (75%), Gaps = 10/275 (3%)
Frame = -3
Query: 1070 LTNLAKAAFGLGVSATVLS-------SSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLI 912
+ L K +FG G L SSL V+GG RA++F+RF G+ ++ EGTHF++
Sbjct: 13 IPKLPKGSFGGGFGLLALGGVGLLALSSLVNVEGGHRAIVFNRFVGIKNKVYNEGTHFIV 72
Query: 911 PILQRPHIFDIRTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKV 732
P +R I+D+R KP + SS++G+KDLQMVN+T+RVLS+P+VS+ P I++TLG +YDE+V
Sbjct: 73 PWFERAEIYDVRAKPRSISSLTGSKDLQMVNITIRVLSKPKVSQLPAIYRTLGKDYDERV 132
Query: 731 LPSIGNEVLKAVVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGME 552
LPSI NE+LK++VAQFNA QL+T+R QVS L+ L+ RA+DFNIELDDV+ITHL++G E
Sbjct: 133 LPSIVNEILKSIVAQFNASQLITQREQVSRLIFKRLVDRAKDFNIELDDVSITHLNFGRE 192
Query: 551 FSRAVEAKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIEL 372
++ A+EAKQVAQQEAER++F+V KA Q++R+ +++AEGE+++AQLI+DA K L++L
Sbjct: 193 YAAAIEAKQVAQQEAERARFLVEKALQDKRSIIVKAEGEAQSAQLINDA-IKQSPYLVQL 251
Query: 371 RRIEASREVAATLARSPNVAYLPGGQSML--FNLN 273
R +EAS+E+A L++SPN Y+ +L F+LN
Sbjct: 252 RTLEASKEIAHILSKSPNKLYISNETLLLNGFDLN 286
>sp|P50085|PHB2_YEAST Prohibitin-2 OS=Saccharomyces cerevisiae GN=PHB2 PE=1
SV=2
Length = 310
Score = 268 bits (684), Expect = 1e-070
Identities = 134/254 (52%), Positives = 194/254 (76%), Gaps = 2/254 (0%)
Frame = -3
Query: 1040 LGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPILQRPHIFDIRTKPHT 861
LG A ++++L+ VDGG RA+++ R GV + EGTHF+ P L P I+D+R KP
Sbjct: 47 LGGGALFINNALFNVDGGHRAIVYSRIHGVSSRIFNEGTHFIFPWLDTPIIYDVRAKPRN 106
Query: 860 FSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPSIGNEVLKAVVAQFN 681
+S++GTKDLQMVN+T RVLSRP+V + PTI++TLG +YDE+VLPSI NEVLKAVVAQFN
Sbjct: 107 VASLTGTKDLQMVNITCRVLSRPDVVQLPTIYRTLGQDYDERVLPSIVNEVLKAVVAQFN 166
Query: 680 ADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSRAVEAKQVAQQEAER 501
A QL+T+R +VS L+R++L++RA FNI LDDV+IT++++ EF+ AVEAKQ+AQQ+A+R
Sbjct: 167 ASQLITQREKVSRLIRENLVRRASKFNILLDDVSITYMTFSPEFTNAVEAKQIAQQDAQR 226
Query: 500 SKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAATLARSP 321
+ FVV KA QE++ V+RA+GE+++A+LI +A K+ +EL+R++ +R++A LA SP
Sbjct: 227 AAFVVDKARQEKQGMVVRAQGEAKSAELIGEAIKKS-RDYVELKRLDTARDIAKILASSP 285
Query: 320 NVAYLPGGQSMLFN 279
N L +++L N
Sbjct: 286 NRVIL-DNEALLLN 298
>sp|A9UMS3|PHB2_XENTR Prohibitin-2 OS=Xenopus tropicalis GN=phb2 PE=2 SV=1
Length = 301
Score = 262 bits (667), Expect = 1e-068
Identities = 139/261 (53%), Positives = 189/261 (72%), Gaps = 3/261 (1%)
Frame = -3
Query: 1055 KAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTV-GEGTHFLIPILQRPHIFDI 879
K G G A + S++TV+GG RA+ F+R GV T+ EG HF P Q P I+DI
Sbjct: 24 KLLLGAGAVAYAVKESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRFPWFQYPIIYDI 83
Query: 878 RTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPSIGNEVLKA 699
R +P SS +G+KDLQMVN+TLRVLSRP S P ++Q LGL+YDE+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNITLRVLSRPLASELPFMYQRLGLDYDERVLPSIVNEVLKS 143
Query: 698 VVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSRAVEAKQVA 519
VVA+FNA QL+T+R QVS L+R L +RA+DF+I LDDVAIT LS+ E++ AVE+KQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSIILDDVAITELSFSREYTAAVESKQVA 203
Query: 518 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 339
QQEA+R++F+V KA Q+++ +++AEGE+ AA++I DA +K G ++LRRI A++ +A
Sbjct: 204 QQEAQRAQFLVEKAKQDQKQKIVQAEGEAAAAKMIGDALSK-NPGYLKLRRIRAAQSIAK 262
Query: 338 TLARSPNVAYLPGGQSMLFNL 276
T+A S N YL S++ NL
Sbjct: 263 TIASSQNRVYL-NADSLVLNL 282
>sp|Q5RB19|PHB2_PONAB Prohibitin-2 OS=Pongo abelii GN=PHB2 PE=2 SV=1
Length = 299
Score = 259 bits (661), Expect = 6e-068
Identities = 136/261 (52%), Positives = 191/261 (73%), Gaps = 3/261 (1%)
Frame = -3
Query: 1055 KAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTV-GEGTHFLIPILQRPHIFDI 879
K G G A + S++TV+GG RA+ F+R GV T+ EG HF IP Q P I+DI
Sbjct: 24 KLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83
Query: 878 RTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPSIGNEVLKA 699
R +P SS +G+KDLQMVN++LRVLSRP P+++Q LGL+Y+E+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKS 143
Query: 698 VVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSRAVEAKQVA 519
VVA+FNA QL+T+R QVS L+R L +RA+DF++ LDDVAIT LS+ E++ AVEAKQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVA 203
Query: 518 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 339
QQEA+R++F+V KA QE+R +++AEGE+EAA+++ +A +K G I+LR+I A++ ++
Sbjct: 204 QQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISK 262
Query: 338 TLARSPNVAYLPGGQSMLFNL 276
T+A S N Y P +++ NL
Sbjct: 263 TIATSQNRIY-PTADNLVLNL 282
>sp|Q2HJ97|PHB2_BOVIN Prohibitin-2 OS=Bos taurus GN=PHB2 PE=2 SV=1
Length = 299
Score = 258 bits (659), Expect = 1e-067
Identities = 135/258 (52%), Positives = 188/258 (72%), Gaps = 2/258 (0%)
Frame = -3
Query: 1055 KAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTV-GEGTHFLIPILQRPHIFDI 879
K G G A + S++TV+GG RA+ F+R GV T+ EG HF IP Q P I+DI
Sbjct: 24 KLLLGAGAVAYGIRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83
Query: 878 RTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPSIGNEVLKA 699
R +P SS +G+KDLQMVN++LRVLSRP P+++Q LGL+Y+E+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNISLRVLSRPNAMELPSMYQRLGLDYEERVLPSIVNEVLKS 143
Query: 698 VVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSRAVEAKQVA 519
VVA+FNA QL+T+R QVS L+R L +RA+DF++ LDDVAIT LS+ E++ AVEAKQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVA 203
Query: 518 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 339
QQEA+R++F+V KA QE+R +++AEGE+EAA+++ +A +K G I+LR+I A++ ++
Sbjct: 204 QQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAARMLGEALSK-NPGYIKLRKIRAAQNISK 262
Query: 338 TLARSPNVAYLPGGQSML 285
T+A S N YL +L
Sbjct: 263 TIATSQNRIYLTADNLVL 280
>sp|Q99623|PHB2_HUMAN Prohibitin-2 OS=Homo sapiens GN=PHB2 PE=1 SV=2
Length = 299
Score = 258 bits (659), Expect = 1e-067
Identities = 135/258 (52%), Positives = 188/258 (72%), Gaps = 2/258 (0%)
Frame = -3
Query: 1055 KAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTV-GEGTHFLIPILQRPHIFDI 879
K G G A + S++TV+GG RA+ F+R GV T+ EG HF IP Q P I+DI
Sbjct: 24 KLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83
Query: 878 RTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPSIGNEVLKA 699
R +P SS +G+KDLQMVN++LRVLSRP P+++Q LGL+Y+E+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKS 143
Query: 698 VVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSRAVEAKQVA 519
VVA+FNA QL+T+R QVS L+R L +RA+DF++ LDDVAIT LS+ E++ AVEAKQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVA 203
Query: 518 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 339
QQEA+R++F+V KA QE+R +++AEGE+EAA+++ +A +K G I+LR+I A++ ++
Sbjct: 204 QQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISK 262
Query: 338 TLARSPNVAYLPGGQSML 285
T+A S N YL +L
Sbjct: 263 TIATSQNRIYLTADNLVL 280
>sp|O35129|PHB2_MOUSE Prohibitin-2 OS=Mus musculus GN=Phb2 PE=1 SV=1
Length = 299
Score = 258 bits (659), Expect = 1e-067
Identities = 135/258 (52%), Positives = 188/258 (72%), Gaps = 2/258 (0%)
Frame = -3
Query: 1055 KAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTV-GEGTHFLIPILQRPHIFDI 879
K G G A + S++TV+GG RA+ F+R GV T+ EG HF IP Q P I+DI
Sbjct: 24 KLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83
Query: 878 RTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPSIGNEVLKA 699
R +P SS +G+KDLQMVN++LRVLSRP P+++Q LGL+Y+E+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKS 143
Query: 698 VVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSRAVEAKQVA 519
VVA+FNA QL+T+R QVS L+R L +RA+DF++ LDDVAIT LS+ E++ AVEAKQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVA 203
Query: 518 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 339
QQEA+R++F+V KA QE+R +++AEGE+EAA+++ +A +K G I+LR+I A++ ++
Sbjct: 204 QQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISK 262
Query: 338 TLARSPNVAYLPGGQSML 285
T+A S N YL +L
Sbjct: 263 TIATSQNRIYLTADNLVL 280
>sp|Q5XIH7|PHB2_RAT Prohibitin-2 OS=Rattus norvegicus GN=Phb2 PE=1 SV=1
Length = 299
Score = 258 bits (659), Expect = 1e-067
Identities = 135/258 (52%), Positives = 188/258 (72%), Gaps = 2/258 (0%)
Frame = -3
Query: 1055 KAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTV-GEGTHFLIPILQRPHIFDI 879
K G G A + S++TV+GG RA+ F+R GV T+ EG HF IP Q P I+DI
Sbjct: 24 KLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83
Query: 878 RTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPSIGNEVLKA 699
R +P SS +G+KDLQMVN++LRVLSRP P+++Q LGL+Y+E+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKS 143
Query: 698 VVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSRAVEAKQVA 519
VVA+FNA QL+T+R QVS L+R L +RA+DF++ LDDVAIT LS+ E++ AVEAKQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVA 203
Query: 518 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 339
QQEA+R++F+V KA QE+R +++AEGE+EAA+++ +A +K G I+LR+I A++ ++
Sbjct: 204 QQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISK 262
Query: 338 TLARSPNVAYLPGGQSML 285
T+A S N YL +L
Sbjct: 263 TIATSQNRIYLTADNLVL 280
>sp|O94550|PHB2_SCHPO Prohibitin-2 OS=Schizosaccharomyces pombe GN=phb2 PE=2
SV=1
Length = 279
Score = 253 bits (645), Expect = 4e-066
Identities = 131/252 (51%), Positives = 182/252 (72%), Gaps = 1/252 (0%)
Frame = -3
Query: 1040 LGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTVGEGTHFLIPILQRPHIFDIRTKPHT 861
LG++ + +SL+ VDGG RA+ + R G+ + EGTHFLIP ++ +D+R KP
Sbjct: 25 LGLAGFAVQTSLFNVDGGHRAIKYSRIGGIKNLIYPEGTHFLIPWIETAIDYDVRAKPRN 84
Query: 860 FSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPSIGNEVLKAVVAQFN 681
SS++GTKDLQMVN+ RVLSRP+V P I++TLG +YDE+VLPSI NEVLK+VVAQFN
Sbjct: 85 ISSLTGTKDLQMVNINCRVLSRPDVHALPKIYRTLGGDYDERVLPSIVNEVLKSVVAQFN 144
Query: 680 ADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSRAVEAKQVAQQEAER 501
A QL+T+R +VS LVR++L+KRA FNI LDDV++TH+ + EF+ AVEAKQ+AQQ+A+R
Sbjct: 145 ASQLITQRERVSRLVRENLMKRAARFNILLDDVSLTHVQFSPEFTAAVEAKQIAQQDAQR 204
Query: 500 SKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAATLARSP 321
+ F V +A E++ ++RA+GE AAQLI +A K G IELR++E +RE+A L++S
Sbjct: 205 ATFYVDRARMEKQGFIVRAQGEGRAAQLIGEA-IKNKPGFIELRKLETAREIANILSKSN 263
Query: 320 NVAYLPGGQSML 285
N L +L
Sbjct: 264 NKVMLNASTLLL 275
>sp|Q5ZMN3|PHB2_CHICK Prohibitin-2 OS=Gallus gallus GN=PHB2 PE=2 SV=1
Length = 301
Score = 252 bits (641), Expect = 1e-065
Identities = 130/258 (50%), Positives = 188/258 (72%), Gaps = 2/258 (0%)
Frame = -3
Query: 1055 KAAFGLGVSATVLSSSLYTVDGGERAVLFDRFRGVLDQTV-GEGTHFLIPILQRPHIFDI 879
K G G A + S++ V+GG+RA+ F+R GV T+ EG HF IP Q P I+DI
Sbjct: 24 KLLLGAGALAYGVRESVFIVEGGQRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83
Query: 878 RTKPHTFSSVSGTKDLQMVNLTLRVLSRPEVSRPPTIFQTLGLEYDEKVLPSIGNEVLKA 699
R +P SS +G+KDLQMVN++LRVL+RP + P+++Q LGL+Y+E+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNISLRVLTRPNAAELPSMYQRLGLDYEERVLPSIVNEVLKS 143
Query: 698 VVAQFNADQLLTERPQVSALVRDSLIKRARDFNIELDDVAITHLSYGMEFSRAVEAKQVA 519
VVA+FNA QL+T+R QVS L+R L +RA+DF++ LDDVAIT LS+ E++ AVEAKQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVA 203
Query: 518 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 339
QQEA+R++F+V KA QE++ +++AEGE+ AA+++ +A ++ G I+LR+I A++ ++
Sbjct: 204 QQEAQRAQFLVEKAKQEQKQKIVQAEGEATAAKMLGEALSR-NPGYIKLRKIRAAQNISK 262
Query: 338 TLARSPNVAYLPGGQSML 285
T+A S N YL +L
Sbjct: 263 TIAGSQNRVYLTADNLVL 280
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,924,390,942
Number of Sequences: 518415
Number of Extensions: 86924390942
Number of Successful Extensions: 587655121
Number of sequences better than 0.0: 0
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