BLASTX 7.6.2
Query= UN21081 /QuerySize=1531
(1530 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O34524|YOCS_BACSU Uncharacterized sodium-dependent transporte... 234 2e-060
sp|O08705|NTCP_MOUSE Sodium/bile acid cotransporter OS=Mus muscu... 115 1e-024
sp|Q12908|NTCP2_HUMAN Ileal sodium/bile acid cotransporter OS=Ho... 114 2e-024
sp|Q96EP9|NTCP4_HUMAN Sodium/bile acid cotransporter 4 OS=Homo s... 113 4e-024
sp|Q3UEZ8|NTCP4_MOUSE Sodium/bile acid cotransporter 4 OS=Mus mu... 113 4e-024
sp|Q5PT56|NTCP4_RAT Sodium/bile acid cotransporter 4 OS=Rattus n... 113 4e-024
sp|P26435|NTCP_RAT Sodium/bile acid cotransporter OS=Rattus norv... 112 1e-023
sp|Q62633|NTCP2_RAT Ileal sodium/bile acid cotransporter OS=Ratt... 111 1e-023
sp|P70172|NTCP2_MOUSE Ileal sodium/bile acid cotransporter OS=Mu... 111 2e-023
sp|Q28727|NTCP2_RABIT Ileal sodium/bile acid cotransporter OS=Or... 111 2e-023
sp|P09131|P3_HUMAN P3 protein OS=Homo sapiens GN=SLC10A3 PE=2 SV=1 110 4e-023
sp|Q60414|NTCP2_CRIGR Ileal sodium/bile acid cotransporter OS=Cr... 107 3e-022
sp|Q0V8N6|P3_BOVIN P3 protein OS=Bos taurus GN=SLC10A3 PE=2 SV=1 107 3e-022
sp|P21129|P3_MOUSE P3 protein OS=Mus musculus GN=Slc10a3 PE=2 SV=2 102 9e-021
sp|Q70EX6|SOAT_RAT Solute carrier family 10 member 6 OS=Rattus n... 100 3e-020
sp|Q5PT55|NTCP5_HUMAN Sodium/bile acid cotransporter 5 OS=Homo s... 97 2e-019
sp|Q5PT54|NTCP5_MOUSE Sodium/bile acid cotransporter 5 OS=Mus mu... 97 3e-019
sp|Q4JLT5|NTCP5_RAT Sodium/bile acid cotransporter 5 OS=Rattus n... 95 1e-018
sp|A6QP84|SOAT_BOVIN Solute carrier family 10 member 6 OS=Bos ta... 95 1e-018
sp|Q3KNW5|SOAT_HUMAN Solute carrier family 10 member 6 OS=Homo s... 92 7e-018
>sp|O34524|YOCS_BACSU Uncharacterized sodium-dependent transporter yocS
OS=Bacillus subtilis GN=yocS PE=3 SV=1
Length = 321
Score = 234 bits (595), Expect = 2e-060
Identities = 128/299 (42%), Positives = 188/299 (62%), Gaps = 4/299 (1%)
Frame = -1
Query: 1182 FPVWVSLGCLLGLVKPGAFNWVTPDLTIIGLTITMLGMGMTLTLDDLRGALKMPKELFAG 1003
F +WV + +LG P F W++ +TI L I M GMG+TL DD + ++ P ++ G
Sbjct: 15 FGIWVIVFAVLGFSFPSLFTWISSYITIF-LGIIMFGMGLTLQADDFKELVRKPWQVIIG 73
Query: 1002 FLLQYSVMPLSAFLVSKLLNLPSHYAAGLILVGCCPGGTASNIVTYIARGNVALSVLMTA 823
+ QY++MPL AF ++ L+LP+ A G+ILVGCCPGGTASN++T++A+GN ALSV +T
Sbjct: 74 VIAQYTIMPLVAFGLAFGLHLPAEIAVGVILVGCCPGGTASNVMTFLAKGNTALSVAVTT 133
Query: 822 ASTLSAVIMTPLLTAKLAKQYVAVDALGLVKSTLQVVLLPVLAGAFMNQYFQR-VVKFVS 646
STL A ++TPLL AK+++ V L S LQ VL P++AG + +F++ V K V
Sbjct: 134 ISTLLAPVVTPLLIMLFAKEWLPVSPGSLFISILQAVLFPIIAGLIVKMFFRKQVAKAVH 193
Query: 645 PLMAPVAVGTVAILCGTAIGQNASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVA 466
L +G VAI+ G N +L SG + +L + G+L G+L ++LL++D
Sbjct: 194 ALPLVSVIGIVAIVSAVVSG-NRENLLQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYP 252
Query: 465 SSRTVSIEVGMQNSVLGLVLAAEHFGNPLTAVPCAVSSVCHSIIGSVLAGVWRRSAPKQ 289
S + ++IEVGMQNS LG LA HF +PL+AVP A+ SV H++ GS+LA W + K+
Sbjct: 253 SQKAIAIEVGMQNSGLGAALATAHF-SPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKK 310
>sp|O08705|NTCP_MOUSE Sodium/bile acid cotransporter OS=Mus musculus GN=Slc10a1
PE=2 SV=1
Length = 362
Score = 115 bits (286), Expect = 1e-024
Identities = 72/235 (30%), Positives = 120/235 (51%), Gaps = 10/235 (4%)
Frame = -1
Query: 1107 LTIIGLTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHY 928
+ ++ L + ML +G T+ ++ PK + + QY +MPLSAFL+ K+ +L S
Sbjct: 30 ILVVMLLLIMLSLGCTMEFSKIKAHFWKPKGVIIAIVAQYGIMPLSAFLLGKVFHLTSIE 89
Query: 927 AAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAKQYVAVD 748
A +++ GC PGG SN+ T +G++ LS++MT S+ +A+ M PLL +K D
Sbjct: 90 ALAILICGCSPGGNLSNLFTLAMKGDMNLSIVMTTCSSFTALGMMPLLLYIYSKGIYDGD 149
Query: 747 ALGLV-----KSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAVG---TVAILCGTA 592
V +L +VL+P G F+ V +V L A + + +VA+ +
Sbjct: 150 LKDKVPYKGIMLSLVMVLIPCAIGIFLKSKRPHYVPYV--LKAGMIITFSLSVAVTVLSV 207
Query: 591 IGQNASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQN 427
I S + ++ L+ +GFL GY+ S L R++ + RT+S+E G QN
Sbjct: 208 INVGNSIMFVMTPHLLATSSLMPFTGFLMGYILSALFRLNPSCRRTISMETGFQN 262
>sp|Q12908|NTCP2_HUMAN Ileal sodium/bile acid cotransporter OS=Homo sapiens
GN=SLC10A2 PE=1 SV=1
Length = 348
Score = 114 bits (284), Expect = 2e-024
Identities = 74/236 (31%), Positives = 126/236 (53%), Gaps = 10/236 (4%)
Frame = -1
Query: 1107 LTIIGLTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHY 928
LTI+ L + M MG + + G +K P + GFL Q+ +MPL+ F++S ++
Sbjct: 38 LTIL-LALVMFSMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQ 96
Query: 927 AAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAKQYVAVD 748
A ++++GCCPGGTASNI+ Y G++ LSV MT STL A+ M PL K +V
Sbjct: 97 AVVVLIIGCCPGGTASNILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSG 156
Query: 747 ALGL----VKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAVGTVAILCGTAIG-- 586
++ + + ++L +++PV G F+N + + K + L G + I+ +G
Sbjct: 157 SIVIPYDNIGTSLVALVVPVSIGMFVNHKWPQKAKII--LKIGSIAGAILIVLIAVVGGI 214
Query: 585 QNASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQNSVL 418
SA + + K ++ + ++G+ G+L +R+ + RTV+ E GMQN+ L
Sbjct: 215 LYQSAWIIAPKLWIIG-TIFPVAGYSLGFLLARIAGLPWYRCRTVAFETGMQNTQL 269
>sp|Q96EP9|NTCP4_HUMAN Sodium/bile acid cotransporter 4 OS=Homo sapiens
GN=SLC10A4 PE=2 SV=2
Length = 437
Score = 113 bits (282), Expect = 4e-024
Identities = 72/230 (31%), Positives = 118/230 (51%), Gaps = 10/230 (4%)
Frame = -1
Query: 1092 LTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHYAAGLI 913
L ITMLG+G T+ ++ ++ P L Q+ ++PL AFL++ L A ++
Sbjct: 113 LCITMLGLGCTVDVNHFGAHVRRPVGALLAALCQFGLLPLLAFLLALAFKLDEVAAVAVL 172
Query: 912 LVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLT-----AKLAKQYVAVD 748
L GCCPGG SN+++ + G++ LS++MT +STL A+++ PL A + V +
Sbjct: 173 LCGCCPGGNLSNLMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWIYSWAWINTPIVQLL 232
Query: 747 ALGLVKSTLQVVLLPVLAGAFMNQYFQRVVKF---VSPLMAPVAVGTVAILCGTAIGQNA 577
LG V TL L+P+ G F+ + RV + VS V + + I+ GT +G
Sbjct: 233 PLGTVTLTLCSTLIPIGLGVFIRYKYSRVADYIVKVSLWSLLVTLVVLFIMTGTMLGPEL 292
Query: 576 SAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQN 427
A + + V+ + + L+G+ GY + L + RTV +E G QN
Sbjct: 293 LASIPAAVYVI--AIFMPLAGYASGYGLATLFHLPPNCKRTVCLETGSQN 340
>sp|Q3UEZ8|NTCP4_MOUSE Sodium/bile acid cotransporter 4 OS=Mus musculus
GN=Slc10a4 PE=2 SV=1
Length = 437
Score = 113 bits (282), Expect = 4e-024
Identities = 72/230 (31%), Positives = 118/230 (51%), Gaps = 10/230 (4%)
Frame = -1
Query: 1092 LTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHYAAGLI 913
L ITMLG+G T+ ++ ++ P L Q+ +PL AFL++ + L A ++
Sbjct: 113 LCITMLGLGCTVDVNHFGAHVRRPVGALLAALCQFGFLPLLAFLLALIFKLDEVAAVAVL 172
Query: 912 LVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLL-----TAKLAKQYVAVD 748
L GCCPGG SN+++ + G++ LS++MT +STL A+++ PL A + V +
Sbjct: 173 LCGCCPGGNLSNLMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWIYSRAWINTPLVQLL 232
Query: 747 ALGLVKSTLQVVLLPVLAGAFMNQYFQRVVKF---VSPLMAPVAVGTVAILCGTAIGQNA 577
LG V TL L+P+ G F+ + RV + VS V + + I+ GT +G
Sbjct: 233 PLGAVTLTLCSTLIPIGLGVFIRYKYNRVADYIVKVSLWSLLVTLVVLFIMTGTMLGPEL 292
Query: 576 SAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQN 427
A + + V + + + L+G+ GY + L + RTV +E G QN
Sbjct: 293 LASIPA--TVYVVAIFMPLAGYASGYGLATLFHLPPNCKRTVCLETGSQN 340
>sp|Q5PT56|NTCP4_RAT Sodium/bile acid cotransporter 4 OS=Rattus norvegicus
GN=Slc10a4 PE=2 SV=1
Length = 437
Score = 113 bits (282), Expect = 4e-024
Identities = 73/230 (31%), Positives = 117/230 (50%), Gaps = 10/230 (4%)
Frame = -1
Query: 1092 LTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHYAAGLI 913
L ITMLG+G T+ ++ ++ P L Q+ +PL AFL++ L A ++
Sbjct: 113 LCITMLGLGCTVDVNHFGAHVRRPVGALLAALCQFGFLPLLAFLLALAFKLDEVAAVAVL 172
Query: 912 LVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLL-----TAKLAKQYVAVD 748
L GCCPGG SN+++ + G++ LS++MT +STL A+++ PL A + V +
Sbjct: 173 LCGCCPGGNLSNLMSLLVDGDMNLSIIMTISSTLLALVLMPLCLWIYSRAWINTPLVQLL 232
Query: 747 ALGLVKSTLQVVLLPVLAGAFMNQYFQRVVKF---VSPLMAPVAVGTVAILCGTAIGQNA 577
LG V TL L+P+ G F+ + RV + VS V + + I+ GT +G
Sbjct: 233 PLGAVTLTLCSTLIPIGLGVFIRYKYNRVADYIVKVSLCSLLVTLVVLFIMTGTMLGPEL 292
Query: 576 SAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQN 427
A + + VV + + L+G+ GY + L + RTV +E G QN
Sbjct: 293 LASIPAAVYVV--AIFMPLAGYASGYGLATLFHLPPNCKRTVCLETGSQN 340
>sp|P26435|NTCP_RAT Sodium/bile acid cotransporter OS=Rattus norvegicus
GN=Slc10a1 PE=2 SV=1
Length = 362
Score = 112 bits (278), Expect = 1e-023
Identities = 68/233 (29%), Positives = 118/233 (50%), Gaps = 6/233 (2%)
Frame = -1
Query: 1107 LTIIGLTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHY 928
+ ++ L + ML +G T+ ++ L PK + + Q+ +MPL+AFL+ K+ +L +
Sbjct: 30 ILVLMLLLIMLSLGCTMEFSKIKAHLWKPKGVIVALVAQFGIMPLAAFLLGKIFHLSNIE 89
Query: 927 AAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAKQYVAVD 748
A +++ GC PGG SN+ T +G++ LS++MT S+ SA+ M PLL +K D
Sbjct: 90 ALAILICGCSPGGNLSNLFTLAMKGDMNLSIVMTTCSSFSALGMMPLLLYVYSKGIYDGD 149
Query: 747 ALGLV-----KSTLQVVLLPVLAGAFMNQYFQRVVKFV-SPLMAPVAVGTVAILCGTAIG 586
V +L +VL+P G + V ++ M + +VA+ + I
Sbjct: 150 LKDKVPYKGIMISLVIVLIPCTIGIVLKSKRPHYVPYILKGGMIITFLLSVAVTALSVIN 209
Query: 585 QNASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQN 427
S + ++ L+ SGFL GY+ S L +++ + RT+S+E G QN
Sbjct: 210 VGNSIMFVMTPHLLATSSLMPFSGFLMGYILSALFQLNPSCRRTISMETGFQN 262
>sp|Q62633|NTCP2_RAT Ileal sodium/bile acid cotransporter OS=Rattus norvegicus
GN=Slc10a2 PE=2 SV=1
Length = 348
Score = 111 bits (277), Expect = 1e-023
Identities = 76/239 (31%), Positives = 124/239 (51%), Gaps = 16/239 (6%)
Frame = -1
Query: 1107 LTIIGLTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHY 928
LTI+ L + M MG + ++ G +K P +F GFL Q+ +MPL+ F++S +
Sbjct: 38 LTIL-LAMVMFSMGCNVEINKFLGHIKRPWGIFVGFLCQFGIMPLTGFILSVASGILPVQ 96
Query: 927 AAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAKQYV--- 757
A ++++GCCPGGT SNI+ Y G++ LSV MT STL A+ M PL K +V
Sbjct: 97 AVVVLIMGCCPGGTGSNILAYWIDGDMDLSVSMTTCSTLLALGMMPLCLFIYTKMWVDSG 156
Query: 756 ----AVDALGLVKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAVGTVAILCGTAI 589
D++G+ +L +++PV G F+N + + K + L G + I+ +
Sbjct: 157 TIVIPYDSIGI---SLVALVIPVSIGMFVNHKWPQKAKII--LKIGSIAGAILIVLIAVV 211
Query: 588 G--QNASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQNSVL 418
G SA + K ++ + ++G+ G+ +RL RTV++E GMQN+ L
Sbjct: 212 GGILYQSAWIIEPKLWIIG-TIFPIAGYSLGFFLARLAGQPWYRCRTVALETGMQNTQL 269
>sp|P70172|NTCP2_MOUSE Ileal sodium/bile acid cotransporter OS=Mus musculus
GN=Slc10a2 PE=2 SV=2
Length = 348
Score = 111 bits (276), Expect = 2e-023
Identities = 77/245 (31%), Positives = 123/245 (50%), Gaps = 15/245 (6%)
Frame = -1
Query: 1125 NWVTPDLTIIGLTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLL 946
N V + I L + M MG + + G +K P +F GFL Q+ +MPL+ F++S
Sbjct: 31 NTVMSTVLTILLAMVMFSMGCNVEVHKFLGHIKRPWGIFVGFLCQFGIMPLTGFILSVAS 90
Query: 945 NLPSHYAAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAK 766
+ A ++++GCCPGGT SNI+ Y G++ LSV MT STL A+ M PL K
Sbjct: 91 GILPVQAVVVLIMGCCPGGTGSNILAYWIDGDMDLSVSMTTCSTLLALGMMPLCLFVYTK 150
Query: 765 QYV-------AVDALGLVKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAVGTVAI 607
+V D++G+ +L +++PV G F+N + + K + L G + I
Sbjct: 151 MWVDSGTIVIPYDSIGI---SLVALVIPVSFGMFVNHKWPQKAKII--LKIGSITGVILI 205
Query: 606 LCGTAIG--QNASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGM 433
+ IG SA + K ++ + ++G+ G+ +RL RTV++E GM
Sbjct: 206 VLIAVIGGILYQSAWIIEPKLWIIG-TIFPIAGYSLGFFLARLAGQPWYRCRTVALETGM 264
Query: 432 QNSVL 418
QN+ L
Sbjct: 265 QNTQL 269
>sp|Q28727|NTCP2_RABIT Ileal sodium/bile acid cotransporter OS=Oryctolagus
cuniculus GN=SLC10A2 PE=2 SV=1
Length = 347
Score = 111 bits (276), Expect = 2e-023
Identities = 73/236 (30%), Positives = 123/236 (52%), Gaps = 10/236 (4%)
Frame = -1
Query: 1107 LTIIGLTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHY 928
LTI+ L + M MG + + G ++ P +F GFL Q+ +MPL+ F+++ +
Sbjct: 39 LTIL-LALVMFSMGCNVEIKKFLGHIRRPWGIFIGFLCQFGIMPLTGFVLAVAFGIMPIQ 97
Query: 927 AAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAKQYVAVD 748
A ++++GCCPGGTASNI+ Y G++ LSV MT STL A+ M PL K +V
Sbjct: 98 AVVVLIMGCCPGGTASNILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLYVYTKMWVDSG 157
Query: 747 ALGL----VKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAVGTVAILCGTAIG-- 586
+ + + ++L +++PV G F+N + + K + L G V I+ +G
Sbjct: 158 TIVIPYDNIGTSLVALVVPVSIGMFVNHKWPQKAKII--LKVGSIAGAVLIVLIAVVGGI 215
Query: 585 QNASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQNSVL 418
SA + K ++ + ++G+ G+ +R+ RTV++E GMQN+ L
Sbjct: 216 LYQSAWIIEPKLWIIG-TIFPMAGYSLGFFLARIAGQPWYRCRTVALETGMQNTQL 270
>sp|P09131|P3_HUMAN P3 protein OS=Homo sapiens GN=SLC10A3 PE=2 SV=1
Length = 477
Score = 110 bits (273), Expect = 4e-023
Identities = 69/233 (29%), Positives = 121/233 (51%), Gaps = 8/233 (3%)
Frame = -1
Query: 1086 ITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHYAAGLILV 907
+ G + L+ L+G ++ P+ + G L Q+ VMPL AFL++K+ LP A GLI+
Sbjct: 202 VNKCSFGCKVELEVLKGLMQSPQPMLLGLLGQFLVMPLYAFLMAKVFMLPKALALGLIIT 261
Query: 906 GCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAKQYVAVDALGL--- 736
PGG S + + + G+V L++ MT ST++A PL +A ++ + L +
Sbjct: 262 CSSPGGGGSYLFSLLLGGDVTLAISMTFLSTVAATGFLPLSSAIYSRLLSIHETLHVPIS 321
Query: 735 -VKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAVGTVAILCGTAIGQNASAILTS 559
+ TL + +P+ G + + + + ++ P + V +L G + + +
Sbjct: 322 KILGTLLFIAIPIAVGVLIKSKLPKFSQLLLQVVKPFSF--VLLLGGLFLAYRMGVFILA 379
Query: 558 GKQ--VVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQNSVLGLVL 406
G + +V+ + + L G L GY + L++ VA RTVSIEVG+QNS+L L +
Sbjct: 380 GIRLPIVLVGITVPLVGLLVGYCLATCLKLPVAQRRTVSIEVGVQNSLLALAM 432
>sp|Q60414|NTCP2_CRIGR Ileal sodium/bile acid cotransporter OS=Cricetulus
griseus GN=SLC10A2 PE=2 SV=1
Length = 348
Score = 107 bits (266), Expect = 3e-022
Identities = 69/234 (29%), Positives = 120/234 (51%), Gaps = 6/234 (2%)
Frame = -1
Query: 1107 LTIIGLTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHY 928
LTI+ L + M MG + L G L+ P + GFL Q+ +MPL+ F++S +
Sbjct: 38 LTIL-LALVMFSMGCNVELHKFLGHLRRPWGIVVGFLCQFGIMPLTGFVLSVAFGILPVQ 96
Query: 927 AAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAKQYVAVD 748
A +++ GCCPGGTASNI+ Y G++ LSV MT STL A+ M PL K +V
Sbjct: 97 AVVVLIQGCCPGGTASNILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLFIYTKMWVDSG 156
Query: 747 ALGL----VKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAVGTVAILCGTAIGQN 580
+ + + ++L +++PV G ++N + + K + + +A + +L G
Sbjct: 157 TIVIPYDSIGTSLVALVIPVSIGMYVNHKWPQKAKIILKI-GSIAGAILIVLIAVVGGIL 215
Query: 579 ASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQNSVL 418
+ T ++ + + ++G+ G+ +R+ RTV++E G+QN+ L
Sbjct: 216 YQSAWTIEPKLWIIGTIYPIAGYGLGFFLARIAGQPWYRCRTVALETGLQNTQL 269
>sp|Q0V8N6|P3_BOVIN P3 protein OS=Bos taurus GN=SLC10A3 PE=2 SV=1
Length = 477
Score = 107 bits (266), Expect = 3e-022
Identities = 70/233 (30%), Positives = 120/233 (51%), Gaps = 8/233 (3%)
Frame = -1
Query: 1086 ITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHYAAGLILV 907
+ G + L+ L+G L+ P+ + G L Q+ VMP AFL++K+ LP A GLI+
Sbjct: 202 VNKCSFGCKVELEVLKGLLQNPQPMLLGLLGQFLVMPFYAFLMAKVFMLPKALALGLIIT 261
Query: 906 GCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAKQYVAVDALGL--- 736
PGG S + + + G+V L++ MT ST++A PL +A ++ + L +
Sbjct: 262 CSSPGGGGSYLFSLLLGGDVTLAISMTFISTVAATGFLPLSSAIYSRLLSIHETLHVPVS 321
Query: 735 -VKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAVGTVAILCGTAIGQNASAILTS 559
+ TL + +P+ AG + + + + ++ P + V +L G + + +
Sbjct: 322 KILGTLLFIAIPIAAGVVIKSKLPKFSQLLLHVIKPFSF--VLLLGGLFLAYRMGVFILA 379
Query: 558 GKQ--VVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQNSVLGLVL 406
G + +V+ + L G L GY + L++ VA RTVSIEVG+QNS+L L +
Sbjct: 380 GVRLPIVLVGFTVPLVGLLVGYGLATCLKLPVAQRRTVSIEVGVQNSLLALAM 432
>sp|P21129|P3_MOUSE P3 protein OS=Mus musculus GN=Slc10a3 PE=2 SV=2
Length = 473
Score = 102 bits (253), Expect = 9e-021
Identities = 68/233 (29%), Positives = 118/233 (50%), Gaps = 8/233 (3%)
Frame = -1
Query: 1086 ITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHYAAGLILV 907
+ G + L+ L+ L+ P+ + G L Q+ VMP AFL++K+ LP A GLI+
Sbjct: 198 VNKCSFGCKVELEVLKELLQSPQPMLLGLLGQFLVMPFYAFLMAKVFMLPKALALGLIIT 257
Query: 906 GCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAKQYVAVDALGL--- 736
PGG S + + + G+V L++ MT ST++A PL +A + + L +
Sbjct: 258 CSSPGGGGSYLFSLLLGGDVTLAISMTFISTVAATGFLPLSSAIYSYLLSIHETLHVPIS 317
Query: 735 -VKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAVGTVAILCGTAIGQNASAILTS 559
+ TL + +P+ AG + + + + ++ P + + +L G + + +
Sbjct: 318 KILGTLLFIAIPIAAGVVIKSKLPKFSELLLQVIKPFSF--ILLLGGLFLAYHMGVFILV 375
Query: 558 GKQ--VVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQNSVLGLVL 406
G + +V+ + L G L GY + L++ VA RTVSIEVG+QNS+L L +
Sbjct: 376 GVRLPIVLVGFTVPLVGLLVGYSLAICLKLPVAQRRTVSIEVGVQNSLLALAM 428
>sp|Q70EX6|SOAT_RAT Solute carrier family 10 member 6 OS=Rattus norvegicus
GN=Slc10a6 PE=2 SV=1
Length = 370
Score = 100 bits (248), Expect = 3e-020
Identities = 71/258 (27%), Positives = 128/258 (49%), Gaps = 16/258 (6%)
Frame = -1
Query: 1152 LGLVKPGAFNWVTPDLTIIGLTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPL 973
+G+ G+ V L+ + + + M G ++ L L+ P + G L Q+ +MPL
Sbjct: 22 VGMEGQGSLKLVFTVLSAVMVGLVMFSFGCSVESRKLWLHLRRPWGIAVGLLCQFGLMPL 81
Query: 972 SAFLVSKLLNLPSHYAAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMT 793
+A+L++ L A ++++G CPGGT SN++T+ G++ LS+ MT ST++A+ M
Sbjct: 82 TAYLLAIGFGLKPFQAIAVLIMGSCPGGTVSNVLTFWVDGDMDLSISMTTCSTVAALGMM 141
Query: 792 PLLTAKLAKQYVAVDALGL----VKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVA 625
PL + + +L + + TL +++PV +G ++N + + F+ L A
Sbjct: 142 PLCLYVYTRSWTLPQSLTIPYQSIGITLVSLVVPVASGIYVNYRWPKQATFI--LKVGAA 199
Query: 624 VGTVAILCGTAIGQNASAILTSGKQV-----VMACVLLHLSGFLFGYLFSRLLRIDVASS 460
VG + +L G +L G + V++C+ L G + G+L + L
Sbjct: 200 VGGMLLLVVAVTG----VVLAKGWNIDVTLLVISCI-FPLVGHVMGFLLAFLTHQSWQRC 254
Query: 459 RTVSIEVGMQNSVLGLVL 406
RT+SIE G QN L + +
Sbjct: 255 RTISIETGAQNIQLCIAM 272
>sp|Q5PT55|NTCP5_HUMAN Sodium/bile acid cotransporter 5 OS=Homo sapiens
GN=SLC10A5 PE=1 SV=1
Length = 438
Score = 97 bits (241), Expect = 2e-019
Identities = 63/239 (26%), Positives = 111/239 (46%), Gaps = 16/239 (6%)
Frame = -1
Query: 1092 LTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHYAAGLI 913
+ + G + L + K P + G + Q+ +MP FL+S+++ LP A G++
Sbjct: 151 ILLNKCAFGCKIELQLFQTVWKRPLPVILGAVTQFFLMPFCGFLLSQIVALPEAQAFGVV 210
Query: 912 LVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAKQYVAVDALGL- 736
+ CPGG + + G+ L++LMT STL A+IM P+ Y+ LGL
Sbjct: 211 MTCTCPGGGGGYLFALLLDGDFTLAILMTCTSTLLALIMMPV------NSYIYSRILGLS 264
Query: 735 ---------VKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAVGTVAILCGTAIGQ 583
+ STL +L+PV G + F+ ++ P++ + +
Sbjct: 265 GTFHIPVSKIVSTLLFILVPVSIGIVIKHRIPEKASFLERIIRPLSFILMFVGIYLTFTV 324
Query: 582 NASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQNSVLGLVL 406
+ T +V++ +L+ G LFGY F+++ + + +TV+IE GM NS L L +
Sbjct: 325 GLVFLKTDNLEVILLGLLVPALGLLFGYSFAKVCTLPLPVCKTVAIESGMLNSFLALAV 383
>sp|Q5PT54|NTCP5_MOUSE Sodium/bile acid cotransporter 5 OS=Mus musculus
GN=Slc10a5 PE=1 SV=1
Length = 434
Score = 97 bits (240), Expect = 3e-019
Identities = 66/258 (25%), Positives = 117/258 (45%), Gaps = 21/258 (8%)
Frame = -1
Query: 1110 DLTIIGLTITML-----GMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLL 946
D +I L ++M+ G + L+ K P + G ++Q+ +MP FL+S++L
Sbjct: 138 DSSIFLLVLSMILLNKCAFGCKIEFQVLQTVWKRPLPILLGVVIQFFLMPFCGFLLSQIL 197
Query: 945 NLPSHYAAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAK 766
LP A G ++ CPGG + + G+V L++LMT ST A+IM P+
Sbjct: 198 GLPKAQAFGFVMTCTCPGGGGGYLFALLLEGDVTLAILMTCTSTSLALIMMPV------N 251
Query: 765 QYVAVDALGL----------VKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAVGT 616
Y LGL + STL +L+P+ G + + ++ P+++
Sbjct: 252 SYFYSRLLGLAGAFHVPVLKIVSTLLFILMPMSTGVIIKHKMPAKAICLERVVRPLSLTL 311
Query: 615 VAILCGTAIGQNASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVG 436
+ + A + + +V + +L+ G LFGY +++ + + +TV++E G
Sbjct: 312 MFVGIYLAFRMGLVFLRMANLEVFLLGLLVPALGLLFGYSLAKVYLLPLPVCKTVALETG 371
Query: 435 MQNSVLGLVLAAEHFGNP 382
M NS L L + F P
Sbjct: 372 MLNSFLALAIIQLSFSQP 389
>sp|Q4JLT5|NTCP5_RAT Sodium/bile acid cotransporter 5 OS=Rattus norvegicus
GN=Slc10a5 PE=2 SV=1
Length = 434
Score = 95 bits (234), Expect = 1e-018
Identities = 63/244 (25%), Positives = 113/244 (46%), Gaps = 16/244 (6%)
Frame = -1
Query: 1107 LTIIGLTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLSAFLVSKLLNLPSHY 928
L ++ + + G + L L+ K P + G + Q+ +MP FL+S++L L
Sbjct: 144 LVLLMILLNKCAFGCKIELQVLQTVWKRPLPILLGAVTQFFLMPFCGFLLSQILGLSKAQ 203
Query: 927 AAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTPLLTAKLAKQYVAVD 748
A G ++ CPGG + + G+V L++LM ST A+IM P+ Y+
Sbjct: 204 AFGFVMTCTCPGGGGGYLFALLLEGDVTLAILMACTSTSLALIMMPV------NSYLYSC 257
Query: 747 ALGL----------VKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAVGTVAILCG 598
LGL + STL +L PV G + + + ++ P+++ + +
Sbjct: 258 LLGLAGVFHVPVLKIVSTLLFILTPVSIGIVIKHRMPKKAVCLERVVQPLSLTLMLVGVY 317
Query: 597 TAIGQNASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIEVGMQNSVL 418
A + + +V + +L+ + GF FGY F+++ + + +TV+IE GM NS L
Sbjct: 318 LAFRMGLVFLRMANLEVFLLGLLVPVLGFSFGYSFAKVYLLPLPVCKTVAIESGMLNSFL 377
Query: 417 GLVL 406
L +
Sbjct: 378 ALAI 381
>sp|A6QP84|SOAT_BOVIN Solute carrier family 10 member 6 OS=Bos taurus GN=SLC10A6
PE=2 SV=2
Length = 377
Score = 95 bits (234), Expect = 1e-018
Identities = 67/245 (27%), Positives = 120/245 (48%), Gaps = 5/245 (2%)
Frame = -1
Query: 1149 GLVKPGAFNWVTPDLTIIGLTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPLS 970
GL G + V ++ + + + M +G ++ + L G ++ P + G L Q+ +MPL
Sbjct: 23 GLKAFGNLDLVFTVVSALMIGLLMFSLGCSVEVQKLWGHIRRPWGIAVGMLCQFGLMPLI 82
Query: 969 AFLVSKLLNLPSHYAAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMTP 790
A+L+ +L A ++++GCCPGGT SNI T+ G++ LS+ MT ST++A+ M P
Sbjct: 83 AYLLIISFSLKPLQAIAVLIMGCCPGGTVSNIFTFWVDGDMDLSISMTTCSTMAALGMMP 142
Query: 789 LLTAKLAKQYVAVDALGL----VKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVAV 622
L + L + + TL +++PV G ++N + + K + + A +A
Sbjct: 143 LCLYLYTLSWNLEQNLTIPYQNIGITLVCLIIPVAFGIYVNYRWPKQSKIILKIGA-IAG 201
Query: 621 GTVAILCGTAIGQNASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSIE 442
G + ++ A +S ++M + L G G+L + L RT+S+E
Sbjct: 202 GLLFLVVTGAGMVLMKEFWSSDIILLMISFIFPLIGHATGFLLALLTHQSWQRCRTISLE 261
Query: 441 VGMQN 427
G QN
Sbjct: 262 TGTQN 266
>sp|Q3KNW5|SOAT_HUMAN Solute carrier family 10 member 6 OS=Homo sapiens
GN=SLC10A6 PE=1 SV=2
Length = 377
Score = 92 bits (228), Expect = 7e-018
Identities = 64/246 (26%), Positives = 117/246 (47%), Gaps = 5/246 (2%)
Frame = -1
Query: 1152 LGLVKPGAFNWVTPDLTIIGLTITMLGMGMTLTLDDLRGALKMPKELFAGFLLQYSVMPL 973
+GL G V ++ + + + M +G ++ + L ++ P + G L Q+ +MP
Sbjct: 22 VGLEVHGNLELVFTVVSTVMMGLLMFSLGCSVEIRKLWSHIRRPWGIAVGLLCQFGLMPF 81
Query: 972 SAFLVSKLLNLPSHYAAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTLSAVIMT 793
+A+L++ +L A ++++GCCPGGT SNI T+ G++ LS+ MT ST++A+ M
Sbjct: 82 TAYLLAISFSLKPVQAIAVLIMGCCPGGTISNIFTFWVDGDMDLSISMTTCSTVAALGMM 141
Query: 792 PLLTAKLAKQYVAVDALGL----VKSTLQVVLLPVLAGAFMNQYFQRVVKFVSPLMAPVA 625
PL + L + + TL + +PV G ++N + + K + + A V
Sbjct: 142 PLCIYLYTWSWSLQQNLTIPYQNIGITLVCLTIPVAFGVYVNYRWPKQSKIILKIGAVVG 201
Query: 624 VGTVAILCGTAIGQNASAILTSGKQVVMACVLLHLSGFLFGYLFSRLLRIDVASSRTVSI 445
G + ++ A A S ++ + L G + G+L + RT+S+
Sbjct: 202 -GVLLLVVAVAGVVLAKGSWNSDITLLTISFIFPLIGHVTGFLLALFTHQSWQRCRTISL 260
Query: 444 EVGMQN 427
E G QN
Sbjct: 261 ETGAQN 266
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,924,390,942
Number of Sequences: 518415
Number of Extensions: 86924390942
Number of Successful Extensions: 587655121
Number of sequences better than 0.0: 0
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