BLASTX 7.6.2
Query= UN21446 /QuerySize=2044
(2043 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O23240|D2HDH_ARATH D-2-hydroxyglutarate dehydrogenase, mitoch... 794 5e-229
sp|B8B7X6|D2HDH_ORYSI Probable D-2-hydroxyglutarate dehydrogenas... 601 1e-170
sp|Q7XI14|D2HDH_ORYSJ Probable D-2-hydroxyglutarate dehydrogenas... 601 1e-170
sp|A1L258|D2HDH_DANRE D-2-hydroxyglutarate dehydrogenase, mitoch... 456 4e-127
sp|Q1JPD3|D2HDH_BOVIN D-2-hydroxyglutarate dehydrogenase, mitoch... 455 6e-127
sp|Q8N465|D2HDH_HUMAN D-2-hydroxyglutarate dehydrogenase, mitoch... 452 5e-126
sp|P84850|D2HDH_RAT D-2-hydroxyglutarate dehydrogenase, mitochon... 447 2e-124
sp|Q8CIM3|D2HDH_MOUSE D-2-hydroxyglutarate dehydrogenase, mitoch... 446 3e-124
sp|Q9C1X2|YN53_SCHPO Putative D-lactate dehydrogenase C713.03, m... 421 9e-117
sp|P46681|DLD2_YEAST D-lactate dehydrogenase [cytochrome] 2, mit... 402 6e-111
sp|P39976|DLD3_YEAST D-lactate dehydrogenase [cytochrome] 3 OS=S... 368 9e-101
sp|P94535|GLCD_BACSU Glycolate oxidase subunit glcD OS=Bacillus ... 169 1e-040
>sp|O23240|D2HDH_ARATH D-2-hydroxyglutarate dehydrogenase, mitochondrial
OS=Arabidopsis thaliana GN=D2HGDH PE=1 SV=3
Length = 559
Score = 794 bits (2050), Expect = 5e-229
Identities = 411/474 (86%), Positives = 435/474 (91%), Gaps = 11/474 (2%)
Frame = -1
Query: 1902 SVSGFVSRYESKGKTFESNAGKGRNTELLDHHH--HHHHPCLGGNL-WTMQQYKSFGSSS 1732
SVS VS + + K+ KG+ EL D ++ HHPC+ N+ +QQYK FGSS+
Sbjct: 29 SVSRSVSGFVNHYKS------KGKLFELSDGNYKTELHHPCISRNVGMLLQQYKCFGSSA 82
Query: 1731 SVASKVQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLEIANTDWMHKYRGSSNLMLLP 1552
AS +QRNPLFSSL+ +DVSYFKEILGEK+VVED+ERLE ANTDWMHKY+GSS LMLLP
Sbjct: 83 --ASLIQRNPLFSSLDSKDVSYFKEILGEKNVVEDKERLETANTDWMHKYKGSSKLMLLP 140
Query: 1551 KNTEEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVL 1372
KNT+EVSQIL+YCDSR LAVVPQGGNTGLVGGSVPVFDEVI+NVGLMNK+LSFDEVSGVL
Sbjct: 141 KNTQEVSQILEYCDSRRLAVVPQGGNTGLVGGSVPVFDEVIVNVGLMNKILSFDEVSGVL 200
Query: 1371 VCEAGCILENLAAFLDTKGFVMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTVLGL 1192
VCEAGCILENLA FLDTKGF+MPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTVLGL
Sbjct: 201 VCEAGCILENLATFLDTKGFIMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTVLGL 260
Query: 1191 EAVTANGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPKMSSVNLAFIAC 1012
EAVTANGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPK+SSVNLAFIAC
Sbjct: 261 EAVTANGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPKLSSVNLAFIAC 320
Query: 1011 KDFLSCQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVSSSENFYILIETTG 832
KD+LSCQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVSSSENFYILIETTG
Sbjct: 321 KDYLSCQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVSSSENFYILIETTG 380
Query: 831 SGETYDREKLEAFLLKSLEQGLVSDGVIAQDINQASSFWRIREGITEALQKAGACYKYDL 652
S ET DREKLEAFLLKSLE+GLVSDGVIAQDINQASSFWRIREGITEALQKAGA YKYDL
Sbjct: 381 SDETNDREKLEAFLLKSLEKGLVSDGVIAQDINQASSFWRIREGITEALQKAGAVYKYDL 440
Query: 651 SLPVEEIYNIVNDLRGRLDGLANVMGYGHLGDGNLHLNISAAEYNDKLLGLIEP 490
SLPVEEIYNIVNDLRGRL LANVMGYGHLGDGNLHLNISAAEYNDKLLGLIEP
Sbjct: 441 SLPVEEIYNIVNDLRGRLGDLANVMGYGHLGDGNLHLNISAAEYNDKLLGLIEP 494
Score = 127 bits (318), Expect = 4e-028
Identities = 61/63 (96%)
Frame = -2
Query: 488 VYEWTSKHRGSISAEHGLGVMKANEIFYSKSPETVALMVSIKKLLDPKGILNPYKVLPHS 309
VYEWTSKHRGSISAEHGLGVMKANEIFYSKSPETVALM SIKKLLDPKGILNPYKVLPHS
Sbjct: 496 VYEWTSKHRGSISAEHGLGVMKANEIFYSKSPETVALMASIKKLLDPKGILNPYKVLPHS 555
Query: 308 FFS 300
FS
Sbjct: 556 LFS 558
>sp|B8B7X6|D2HDH_ORYSI Probable D-2-hydroxyglutarate dehydrogenase,
mitochondrial OS=Oryza sativa subsp. indica GN=D2HGDH PE=3 SV=1
Length = 559
Score = 601 bits (1547), Expect = 1e-170
Identities = 287/418 (68%), Positives = 359/418 (85%), Gaps = 1/418 (0%)
Frame = -1
Query: 1740 SSSSVASKVQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLEIANTDWMHKYRGSSNLM 1561
S SS A+ VQRNP +S L DVSYFK ILG+ VV+DE+R+ +AN DWM KY+GSS L+
Sbjct: 79 SFSSAAAHVQRNPAYSVLNSDDVSYFKSILGDSGVVQDEDRVSVANMDWMGKYKGSSQLL 138
Query: 1560 LLPKNTEEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVS 1381
LLPK+T EVS+IL YC+SR LAVVPQGGNTGLVGGSVPV+DEVII++G M+K+++FD V+
Sbjct: 139 LLPKSTAEVSKILSYCNSRRLAVVPQGGNTGLVGGSVPVYDEVIISLGGMDKIITFDNVN 198
Query: 1380 GVLVCEAGCILENLAAFLDTKGFVMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTV 1201
G+L CEAGC+LENL+++++ KGF+MPLDLGAKGSCHIGGN+STNAGGLR IRYGSLHG+V
Sbjct: 199 GILTCEAGCVLENLSSYVENKGFIMPLDLGAKGSCHIGGNISTNAGGLRFIRYGSLHGSV 258
Query: 1200 LGLEAVTANGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPKMSSVNLAF 1021
LGLE V A+G VLDML TLRKDNTGYDLKHLFIGSEGSLGIVTK++ILT K+ S N+AF
Sbjct: 259 LGLEVVLADGTVLDMLTTLRKDNTGYDLKHLFIGSEGSLGIVTKIAILTPAKLPSTNVAF 318
Query: 1020 IACKDFLSCQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVS-SSENFYILI 844
++C D++SCQKLL+ A+R+LGEILSAFEF+D + ++L + +L+GV NP+ S NFY+LI
Sbjct: 319 LSCNDYISCQKLLLAARRSLGEILSAFEFMDRHCINLAMKYLEGVHNPLPVSPYNFYVLI 378
Query: 843 ETTGSGETYDREKLEAFLLKSLEQGLVSDGVIAQDINQASSFWRIREGITEALQKAGACY 664
ETTGS E+YD+ KLEAFLL+S+E GLV+DGVIAQDI+QAS+FWRIREGI+EA K GA Y
Sbjct: 379 ETTGSDESYDKAKLEAFLLRSMEDGLVADGVIAQDISQASNFWRIREGISEASVKVGAVY 438
Query: 663 KYDLSLPVEEIYNIVNDLRGRLDGLANVMGYGHLGDGNLHLNISAAEYNDKLLGLIEP 490
KYDLS+PVE++Y+IV ++R R+ + V+GYGHLGDGNLHLNI + +Y+DK+L IEP
Sbjct: 439 KYDLSIPVEKLYDIVEEMRSRVGDMGQVLGYGHLGDGNLHLNILSTKYSDKMLAQIEP 496
Score = 99 bits (244), Expect = 1e-019
Identities = 48/60 (80%), Positives = 51/60 (85%)
Frame = -2
Query: 488 VYEWTSKHRGSISAEHGLGVMKANEIFYSKSPETVALMVSIKKLLDPKGILNPYKVLPHS 309
VYEWTSK RGSISAEHGLG+MKA++I YSKS E V LM SIKKLLDP ILNPYKVLP S
Sbjct: 498 VYEWTSKQRGSISAEHGLGLMKADKIHYSKSSEAVQLMTSIKKLLDPNSILNPYKVLPQS 557
>sp|Q7XI14|D2HDH_ORYSJ Probable D-2-hydroxyglutarate dehydrogenase,
mitochondrial OS=Oryza sativa subsp. japonica GN=D2HGDH PE=3 SV=1
Length = 559
Score = 601 bits (1547), Expect = 1e-170
Identities = 287/418 (68%), Positives = 359/418 (85%), Gaps = 1/418 (0%)
Frame = -1
Query: 1740 SSSSVASKVQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLEIANTDWMHKYRGSSNLM 1561
S SS A+ VQRNP +S L DVSYFK ILG+ VV+DE+R+ +AN DWM KY+GSS L+
Sbjct: 79 SFSSAAAHVQRNPAYSVLNSDDVSYFKSILGDSGVVQDEDRVSVANMDWMGKYKGSSQLL 138
Query: 1560 LLPKNTEEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVS 1381
LLPK+T EVS+IL YC+SR LAVVPQGGNTGLVGGSVPV+DEVII++G M+K+++FD V+
Sbjct: 139 LLPKSTAEVSKILSYCNSRRLAVVPQGGNTGLVGGSVPVYDEVIISLGGMDKIITFDNVN 198
Query: 1380 GVLVCEAGCILENLAAFLDTKGFVMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTV 1201
G+L CEAGC+LENL+++++ KGF+MPLDLGAKGSCHIGGN+STNAGGLR IRYGSLHG+V
Sbjct: 199 GILTCEAGCVLENLSSYVENKGFIMPLDLGAKGSCHIGGNISTNAGGLRFIRYGSLHGSV 258
Query: 1200 LGLEAVTANGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPKMSSVNLAF 1021
LGLE V A+G VLDML TLRKDNTGYDLKHLFIGSEGSLGIVTK++ILT K+ S N+AF
Sbjct: 259 LGLEVVLADGTVLDMLTTLRKDNTGYDLKHLFIGSEGSLGIVTKIAILTPAKLPSTNVAF 318
Query: 1020 IACKDFLSCQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVSSSE-NFYILI 844
++C D++SCQKLL+ A+R+LGEILSAFEF+D + ++L + +L+GV NP+ S NFY+LI
Sbjct: 319 LSCNDYISCQKLLLAARRSLGEILSAFEFMDRHCINLAMKYLEGVHNPLPVSPFNFYVLI 378
Query: 843 ETTGSGETYDREKLEAFLLKSLEQGLVSDGVIAQDINQASSFWRIREGITEALQKAGACY 664
ETTGS E+YD+ KLEAFLL+S+E GLV+DGVIAQDI+QAS+FWRIREGI+EA K GA Y
Sbjct: 379 ETTGSDESYDKAKLEAFLLRSMEDGLVADGVIAQDISQASNFWRIREGISEASVKVGAVY 438
Query: 663 KYDLSLPVEEIYNIVNDLRGRLDGLANVMGYGHLGDGNLHLNISAAEYNDKLLGLIEP 490
KYDLS+PVE++Y+IV ++R R+ + V+GYGHLGDGNLHLNI + +Y+DK+L IEP
Sbjct: 439 KYDLSIPVEKLYDIVEEMRSRVGDMGQVLGYGHLGDGNLHLNILSTKYSDKMLAQIEP 496
Score = 98 bits (243), Expect = 2e-019
Identities = 48/60 (80%), Positives = 50/60 (83%)
Frame = -2
Query: 488 VYEWTSKHRGSISAEHGLGVMKANEIFYSKSPETVALMVSIKKLLDPKGILNPYKVLPHS 309
VYEWTSK RGSISAEHGLG+MKA +I YSKS E V LM SIKKLLDP ILNPYKVLP S
Sbjct: 498 VYEWTSKQRGSISAEHGLGLMKAEKIHYSKSSEAVQLMASIKKLLDPNSILNPYKVLPQS 557
>sp|A1L258|D2HDH_DANRE D-2-hydroxyglutarate dehydrogenase, mitochondrial
OS=Danio rerio GN=d2hgdh PE=2 SV=1
Length = 533
Score = 456 bits (1171), Expect = 4e-127
Identities = 228/404 (56%), Positives = 300/404 (74%), Gaps = 4/404 (0%)
Frame = -1
Query: 1698 FSSLEPRDVSYFKEILGEKHVVEDEERLEIANTDWMHKYRGSSNLMLLPKNTEEVSQILK 1519
FS + D+S+F+ +L + + D + L+ +N DW+ +GSS+++L PK TE VSQIL+
Sbjct: 70 FSRVTQEDLSFFRALLPGR-TITDPDLLKSSNVDWLKTVQGSSDVLLRPKTTEGVSQILR 128
Query: 1518 YCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVCEAGCILENL 1339
YC+ R+LAV PQGGNTGLVGGSVPVFDE+I++ LMN+V +FD +SG+L C+AGC+LENL
Sbjct: 129 YCNERNLAVCPQGGNTGLVGGSVPVFDEIILSTSLMNQVFAFDNISGILTCQAGCVLENL 188
Query: 1338 AAFLDTKGFVMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTVLGLEAVTANGNVLD 1159
+ +L+ + F+MPLDLGAKGSCHIGGNVSTNAGGLRL+RYGSL GTVLGLE V A+G+VL+
Sbjct: 189 SHYLEERDFIMPLDLGAKGSCHIGGNVSTNAGGLRLLRYGSLRGTVLGLEVVLADGHVLN 248
Query: 1158 MLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPKMSSVNLAFIACKDFLSCQKLLV 979
L TLRKDNTGYDLK LFIGSEG+LG++T VSIL K +VN+AF+ C F +
Sbjct: 249 CLATLRKDNTGYDLKQLFIGSEGTLGVITAVSILCPRKPKAVNVAFLGCSSFQQLLETFQ 308
Query: 978 EAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVSSSENFYILIETTGSGETYDREKLE 799
+ LGEILSAFEFLD + M+L+ HL + NP++ FYI+IET GS T+D EKL
Sbjct: 309 CCRGMLGEILSAFEFLDASCMNLLEKHLK-LTNPITECP-FYIVIETAGSNATHDEEKLH 366
Query: 798 AFLLKSLEQGLVSDGVIAQDINQASSFWRIREGITEALQKAGACYKYDLSLPVEEIYNIV 619
FL + + LV+DG +A + + + W +RE +TEAL G YKYD+SLPVE+IY++V
Sbjct: 367 QFLEEVMTSSLVTDGTVATEATKIKALWSLRERVTEALTHEGYTYKYDISLPVEKIYDLV 426
Query: 618 NDLRGRLDGLA-NVMGYGHLGDGNLHLNISAAEYNDKLLGLIEP 490
D+R L G+A NV+GYGH+GDGNLHLNI++ + LL IEP
Sbjct: 427 QDMRRHLGGMAKNVVGYGHVGDGNLHLNITSPSKDFDLLAAIEP 470
Score = 90 bits (222), Expect = 5e-017
Identities = 43/58 (74%), Positives = 48/58 (82%)
Frame = -2
Query: 488 VYEWTSKHRGSISAEHGLGVMKANEIFYSKSPETVALMVSIKKLLDPKGILNPYKVLP 315
VYEWTS+ +GSISAEHGLG+ K N I+YSK E VALM SIK +LDPKGILNPYK LP
Sbjct: 472 VYEWTSQWKGSISAEHGLGLKKRNYIYYSKPSEAVALMGSIKAMLDPKGILNPYKTLP 529
>sp|Q1JPD3|D2HDH_BOVIN D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Bos
taurus GN=D2HGDH PE=2 SV=2
Length = 544
Score = 455 bits (1170), Expect = 6e-127
Identities = 233/410 (56%), Positives = 301/410 (73%), Gaps = 5/410 (1%)
Frame = -1
Query: 1716 VQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLEIANTDWMHKYRGSSNLMLLPKNTEE 1537
VQR P FS + D++ + ++ + V+ D E LE N DW+ RGSS ++L P+ T+E
Sbjct: 77 VQRLP-FSVVSEDDLAALERVVPGR-VITDPEELEPPNVDWLRTVRGSSKVLLRPRTTQE 134
Query: 1536 VSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVCEAG 1357
V+ IL+YC R+LAV PQGGNTG+VGGS PVFDE+I++ LMN+VLSF +VSGVLVC+AG
Sbjct: 135 VAHILRYCHERNLAVNPQGGNTGMVGGSTPVFDEIILSTALMNQVLSFHDVSGVLVCQAG 194
Query: 1356 CILENLAAFLDTKGFVMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTVLGLEAVTA 1177
C+LE L+ +++ +GF+MPLDLGAKGSCHIGGNV+TNAGGLR++RYGSL GTVLGLE V A
Sbjct: 195 CVLEALSQYVEERGFIMPLDLGAKGSCHIGGNVATNAGGLRVLRYGSLRGTVLGLEVVLA 254
Query: 1176 NGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPKMSSVNLAFIACKDFLS 997
+G VL+ L +LRKDNTGYDLK LFIGSEG+LG++T VSIL PK S+VN+AF+ C F
Sbjct: 255 DGTVLNCLTSLRKDNTGYDLKQLFIGSEGTLGVITAVSILCPPKPSTVNVAFLGCPGFAE 314
Query: 996 CQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVSSSENFYILIETTGSGETY 817
+ + LGEILSAFEF+D M LV HL G+ PV S FY+LIET GSG +
Sbjct: 315 VLQTFRTCRAMLGEILSAFEFMDAECMKLVRLHL-GLSCPVQESP-FYVLIETAGSGPGH 372
Query: 816 DREKLEAFLLKSLEQGLVSDGVIAQDINQASSFWRIREGITEALQKAGACYKYDLSLPVE 637
D EKL FL + L+ GLV+DG + D + W +RE ITEAL + G YKYDLSLP++
Sbjct: 373 DAEKLGCFLEQVLDSGLVTDGTLGSDERRIKMLWALRERITEALSRDGYVYKYDLSLPLD 432
Query: 636 EIYNIVNDLRGRLDGLA-NVMGYGHLGDGNLHLNISAAEYNDKLLGLIEP 490
+Y++V DLR RL A +V+GYGHLGDGNLHLN+++ ++ LLG +EP
Sbjct: 433 RLYDLVGDLRARLGPSAKHVVGYGHLGDGNLHLNVTSEAFSTSLLGALEP 482
Score = 82 bits (202), Expect = 1e-014
Identities = 38/58 (65%), Positives = 45/58 (77%)
Frame = -2
Query: 488 VYEWTSKHRGSISAEHGLGVMKANEIFYSKSPETVALMVSIKKLLDPKGILNPYKVLP 315
VYEWT+ RGS+SAEHGLG K + + YSK PE + LM +K LLDPKGILNPYK+LP
Sbjct: 484 VYEWTAGQRGSVSAEHGLGFKKKDVLGYSKPPEALQLMRQLKALLDPKGILNPYKMLP 541
>sp|Q8N465|D2HDH_HUMAN D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo
sapiens GN=D2HGDH PE=1 SV=3
Length = 521
Score = 452 bits (1162), Expect = 5e-126
Identities = 236/410 (57%), Positives = 298/410 (72%), Gaps = 5/410 (1%)
Frame = -1
Query: 1716 VQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLEIANTDWMHKYRGSSNLMLLPKNTEE 1537
V+R P FS++ +D++ F+ I+ VV D E L+ N DW+ RG S ++L P+ +EE
Sbjct: 54 VRRLP-FSTVSKQDLAAFERIV-PGGVVTDPEALQAPNVDWLRTLRGCSKVLLRPRTSEE 111
Query: 1536 VSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVCEAG 1357
VS IL++C R+LAV PQGGNTG+VGGSVPVFDE+I++ MN+VLSF VSG+LVC+AG
Sbjct: 112 VSHILRHCHERNLAVNPQGGNTGMVGGSVPVFDEIILSTARMNRVLSFHSVSGILVCQAG 171
Query: 1356 CILENLAAFLDTKGFVMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTVLGLEAVTA 1177
C+LE L+ +++ + F+MPLDLGAKGSCHIGGNV+TNAGGLR +RYGSLHGTVLGLE V A
Sbjct: 172 CVLEELSRYVEERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLHGTVLGLEVVLA 231
Query: 1176 NGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPKMSSVNLAFIACKDFLS 997
+G VLD L +LRKDNTGYDLK LFIGSEG+LGI+T VSIL PK +VN+AF+ C F
Sbjct: 232 DGTVLDCLTSLRKDNTGYDLKQLFIGSEGTLGIITTVSILCPPKPRAVNVAFLGCPGFAE 291
Query: 996 CQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVSSSENFYILIETTGSGETY 817
+ K LGEILSAFEF+D M LV HL + +PV S FY+LIET+GS +
Sbjct: 292 VLQTFSTCKGMLGEILSAFEFMDAVCMQLVGRHLH-LASPVQESP-FYVLIETSGSNAGH 349
Query: 816 DREKLEAFLLKSLEQGLVSDGVIAQDINQASSFWRIREGITEALQKAGACYKYDLSLPVE 637
D EKL FL +L GLV+DG +A D + W +RE ITEAL + G YKYDLSLPVE
Sbjct: 350 DAEKLGHFLEHALGSGLVTDGTMATDQRKVKMLWALRERITEALSRDGYVYKYDLSLPVE 409
Query: 636 EIYNIVNDLRGRLDGLA-NVMGYGHLGDGNLHLNISAAEYNDKLLGLIEP 490
+Y+IV DLR RL A +V+GYGHLGDGNLHLN++A ++ LL +EP
Sbjct: 410 RLYDIVTDLRARLGPHAKHVVGYGHLGDGNLHLNVTAEAFSPSLLAALEP 459
>sp|P84850|D2HDH_RAT D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Rattus
norvegicus GN=D2hgdh PE=3 SV=1
Length = 535
Score = 447 bits (1149), Expect = 2e-124
Identities = 229/410 (55%), Positives = 300/410 (73%), Gaps = 5/410 (1%)
Frame = -1
Query: 1716 VQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLEIANTDWMHKYRGSSNLMLLPKNTEE 1537
VQR P FS++ D++ F+ I+ + V+ D E+L+ N DW+ RG S ++L P+ +EE
Sbjct: 68 VQRLP-FSTVSEEDLAAFECIIPGR-VITDPEQLQTCNVDWLRTVRGCSKVLLRPQTSEE 125
Query: 1536 VSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVCEAG 1357
VSQIL++C R+LAV PQGGNTG+VGGSVPVFDEVI++ LMN+V+SF +VSG+LVC+AG
Sbjct: 126 VSQILRHCYKRNLAVNPQGGNTGMVGGSVPVFDEVILSTALMNQVISFHDVSGILVCQAG 185
Query: 1356 CILENLAAFLDTKGFVMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTVLGLEAVTA 1177
C+LE L+ ++ + F+MPLDLGAKGSCHIGGNV+TNAGGLR +RYGSL GTVLGLE V A
Sbjct: 186 CVLEELSRYVQERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLRGTVLGLEVVLA 245
Query: 1176 NGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPKMSSVNLAFIACKDFLS 997
+G +L+ L +LRKDNTGYDLK +FIGSEG+LG++T VSI+ P+ +VN+AF+ C F
Sbjct: 246 DGTILNCLTSLRKDNTGYDLKQMFIGSEGTLGVITAVSIVCPPRPKAVNVAFLGCPGFTE 305
Query: 996 CQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVSSSENFYILIETTGSGETY 817
+ K LGEILSAFEF+D M LV HL + NPV S FY+L+ET+GS +
Sbjct: 306 VLQTFRTCKGQLGEILSAFEFMDAECMQLVGQHLH-LTNPVQESP-FYVLVETSGSSAGH 363
Query: 816 DREKLEAFLLKSLEQGLVSDGVIAQDINQASSFWRIREGITEALQKAGACYKYDLSLPVE 637
D EKL L + L GLV DG +A D + W +RE ITEAL + G +KYDLSLPVE
Sbjct: 364 DAEKLTNVLEQVLNSGLVIDGTMATDQRKVQMLWALRERITEALSRDGYVFKYDLSLPVE 423
Query: 636 EIYNIVNDLRGRLDGLA-NVMGYGHLGDGNLHLNISAAEYNDKLLGLIEP 490
+Y++V DLR RL A +V+GYGHLGDGNLHLN++A ++ +LLG +EP
Sbjct: 424 RLYDLVIDLRTRLGPRAKHVVGYGHLGDGNLHLNVTAEAFSQELLGALEP 473
Score = 81 bits (198), Expect = 3e-014
Identities = 37/58 (63%), Positives = 43/58 (74%)
Frame = -2
Query: 488 VYEWTSKHRGSISAEHGLGVMKANEIFYSKSPETVALMVSIKKLLDPKGILNPYKVLP 315
VY WT++ RGS+SAEHGLG K N + YSK P V LM +K +LDPKGILNPYK LP
Sbjct: 475 VYAWTAEQRGSVSAEHGLGFKKKNVLGYSKPPVAVKLMQQLKAMLDPKGILNPYKTLP 532
>sp|Q8CIM3|D2HDH_MOUSE D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Mus
musculus GN=D2hgdh PE=2 SV=2
Length = 535
Score = 446 bits (1147), Expect = 3e-124
Identities = 228/410 (55%), Positives = 301/410 (73%), Gaps = 5/410 (1%)
Frame = -1
Query: 1716 VQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLEIANTDWMHKYRGSSNLMLLPKNTEE 1537
VQR P FS++ D++ F+ I+ + V+ D E+L+ N DW+ RG S ++L P+ +EE
Sbjct: 68 VQRLP-FSTVSEEDLAAFECIIPGR-VITDPEQLQTCNVDWLKTVRGCSKVLLRPQTSEE 125
Query: 1536 VSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVCEAG 1357
VSQIL++C R+LAV PQGGNTG+VGGSVPVFDEVI++ LMN+V+SF +VSG+LVC+AG
Sbjct: 126 VSQILRHCYKRNLAVNPQGGNTGMVGGSVPVFDEVILSTALMNQVISFHDVSGILVCQAG 185
Query: 1356 CILENLAAFLDTKGFVMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTVLGLEAVTA 1177
C+LE L+ ++ + F+MPLDLGAKGSCHIGGNV+TNAGGLR +RYGSL GTVLGLE V A
Sbjct: 186 CVLEELSRYVQERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLRGTVLGLEVVLA 245
Query: 1176 NGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPKMSSVNLAFIACKDFLS 997
+G +L+ L +LRKDNTGYDLK +FIGSEG+LG++T VSI+ P+ +VN+AF+ C F
Sbjct: 246 DGTILNCLTSLRKDNTGYDLKQMFIGSEGTLGVITAVSIVCPPRPKAVNVAFLGCPGFAE 305
Query: 996 CQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVSSSENFYILIETTGSGETY 817
+ + LGEILSAFEF+D M LV HL + NPV S FY+L+ET+GS +
Sbjct: 306 VLQTFRTCRGMLGEILSAFEFMDTECMQLVGQHLQ-LTNPVQESP-FYVLVETSGSSAGH 363
Query: 816 DREKLEAFLLKSLEQGLVSDGVIAQDINQASSFWRIREGITEALQKAGACYKYDLSLPVE 637
D EKL L + L GLV+DG +A D + W +RE ITEAL + G +KYDLSLPVE
Sbjct: 364 DAEKLTNVLEQVLNSGLVTDGTMATDQRKVQMLWALRERITEALSRDGYVFKYDLSLPVE 423
Query: 636 EIYNIVNDLRGRLDGLA-NVMGYGHLGDGNLHLNISAAEYNDKLLGLIEP 490
+Y++V DLR RL A +V+GYGHLGDGNLHLN++A ++ +LLG +EP
Sbjct: 424 RLYDLVIDLRTRLGPRAKHVVGYGHLGDGNLHLNVTAEAFSRELLGALEP 473
Score = 79 bits (194), Expect = 9e-014
Identities = 36/58 (62%), Positives = 43/58 (74%)
Frame = -2
Query: 488 VYEWTSKHRGSISAEHGLGVMKANEIFYSKSPETVALMVSIKKLLDPKGILNPYKVLP 315
VY WT++ RGS+SAEHGLG K + + YSK P V LM +K +LDPKGILNPYK LP
Sbjct: 475 VYAWTAEQRGSVSAEHGLGFKKKDVLGYSKPPVAVTLMQQLKAMLDPKGILNPYKTLP 532
>sp|Q9C1X2|YN53_SCHPO Putative D-lactate dehydrogenase C713.03, mitochondrial
OS=Schizosaccharomyces pombe GN=SPBC713.03 PE=2 SV=1
Length = 526
Score = 421 bits (1082), Expect = 9e-117
Identities = 215/446 (48%), Positives = 301/446 (67%), Gaps = 30/446 (6%)
Frame = -1
Query: 1770 WTMQQYKSFGSSSSVASKVQRNPLFSSLEPRDVSYFKEILGEKHVV-------EDEERLE 1612
+T + YKS + R+P ++ L +DV FK I+G+ + D L+
Sbjct: 34 FTFESYKS----------LHRDPKYAKLSEQDVQVFKSIIGKDGSLIDGLDKSTDPADLD 83
Query: 1611 IANTDWMHKYRGSSNLMLLPKNTEEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEV 1432
N DWM+KYRG + L L PK T++VS+ILKYC+ + LAVVPQGGNTGLVGGSVPVFDE+
Sbjct: 84 AFNIDWMNKYRGKTQLALKPKTTQQVSEILKYCNQKKLAVVPQGGNTGLVGGSVPVFDEI 143
Query: 1431 IINVGLMNKVLSFDEVSGVLVCEAGCILENLAAFLDTKGFVMPLDLGAKGSCHIGGNVST 1252
++N+GLMN++ +FDE+SGV+ ++G ILEN FL KG++ PLDLGAKGSC +GG +T
Sbjct: 144 VLNLGLMNQIHTFDEISGVITLDSGVILENADNFLAEKGYMFPLDLGAKGSCQVGGCAAT 203
Query: 1251 NAGGLRLIRYGSLHGTVLGLEAVTANGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVT 1072
AGGLRL+RYGSLHG++LG+EAV +G +LD L TLRKDNTG D+K LFIGSEG LG++T
Sbjct: 204 AAGGLRLLRYGSLHGSILGMEAVLPDGTILDNLVTLRKDNTGLDIKQLFIGSEGYLGVIT 263
Query: 1071 KVSILTQPKMSSVNLAFIACKDFLSCQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLD 892
K+S++ + SS N+AF + + K E + +L EILSAFE +DN S LV +
Sbjct: 264 KLSVICPKRPSSTNVAFFGVPSYENVLKAFSETRSHLTEILSAFELMDNTSQTLV-DKYS 322
Query: 891 GVRNPVSSSENFYILIETTGSGETYDREKLEAFLLKSLEQGLVSDGVIAQDINQASSFWR 712
G + P+ FY+L+ET GS + +D +K+ A + LE+ ++SDGV+AQD +Q W
Sbjct: 323 GTQRPLEDEHPFYVLVETQGSNKEHDEQKITALVEDLLEKEIISDGVLAQDESQLRVLWE 382
Query: 711 IREGITEALQKAGA-CYKYDLSLPVEEIYNIVNDLRGRL-----------DGLANVMGYG 568
REGITE L KAG+ YKYD+SLP+ +Y++VND + RL + +V+G+G
Sbjct: 383 RREGITECLAKAGSGVYKYDVSLPLPVLYDLVNDTKKRLIEFNLLDDTPEHPVIDVVGFG 442
Query: 567 HLGDGNLHLNISAAEYNDKLLGLIEP 490
H+GDGNLHLNI+ +++ ++ +EP
Sbjct: 443 HMGDGNLHLNIAVRQFDKRVEKCLEP 468
>sp|P46681|DLD2_YEAST D-lactate dehydrogenase [cytochrome] 2, mitochondrial
OS=Saccharomyces cerevisiae GN=DLD2 PE=1 SV=1
Length = 530
Score = 402 bits (1032), Expect = 6e-111
Identities = 196/375 (52%), Positives = 267/375 (71%), Gaps = 2/375 (0%)
Frame = -1
Query: 1716 VQRNPLFSSLEPRDVSYFKEILGEKHVV--EDEERLEIANTDWMHKYRGSSNLMLLPKNT 1543
V R+P F L D++YFK IL E+ ++ + E L N DWM KY+G S L+L PK+
Sbjct: 52 VHRDPRFKKLTSDDLNYFKSILSEQEILRASESEDLSFYNEDWMRKYKGQSKLVLRPKSV 111
Query: 1542 EEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVCE 1363
E+VS IL YC+ +AVVPQGGNTGLVGGSVP+FDE+I+++ +NK+ FD VSG+L C+
Sbjct: 112 EKVSLILNYCNDEKIAVVPQGGNTGLVGGSVPIFDELILSLANLNKIRDFDPVSGILKCD 171
Query: 1362 AGCILENLAAFLDTKGFVMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTVLGLEAV 1183
AG ILEN ++ + ++ PLDLGAKGSCH+GG V+TNAGGLRL+RYGSLHG+VLGLE V
Sbjct: 172 AGVILENANNYVMEQNYMFPLDLGAKGSCHVGGVVATNAGGLRLLRYGSLHGSVLGLEVV 231
Query: 1182 TANGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPKMSSVNLAFIACKDF 1003
NG +++ + ++RKDNTGYDLK LFIGSEG++GI+T VSILT PK + N+++++ + F
Sbjct: 232 MPNGQIVNSMHSMRKDNTGYDLKQLFIGSEGTIGIITGVSILTVPKPKAFNVSYLSVESF 291
Query: 1002 LSCQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVSSSENFYILIETTGSGE 823
QK+ V A++ L EILSAFEF+D S L + L P+ FYILIET+GS +
Sbjct: 292 EDVQKVFVRARQELSEILSAFEFMDAKSQVLAKSQLKDAAFPLEDEHPFYILIETSGSNK 351
Query: 822 TYDREKLEAFLLKSLEQGLVSDGVIAQDINQASSFWRIREGITEALQKAGACYKYDLSLP 643
+D KLE FL +E+G+V+DGV+AQD + + W+ RE I EA Q G YKYD+SLP
Sbjct: 352 DHDDSKLETFLENVMEEGIVTDGVVAQDETELQNLWKWREMIPEASQANGGVYKYDVSLP 411
Query: 642 VEEIYNIVNDLRGRL 598
++++Y++V RL
Sbjct: 412 LKDLYSLVEATNARL 426
>sp|P39976|DLD3_YEAST D-lactate dehydrogenase [cytochrome] 3 OS=Saccharomyces
cerevisiae GN=DLD3 PE=1 SV=1
Length = 496
Score = 368 bits (944), Expect = 9e-101
Identities = 179/377 (47%), Positives = 255/377 (67%), Gaps = 2/377 (0%)
Frame = -1
Query: 1719 KVQRNPLFSSLEPRDVSYFKEILGEKHVVEDEERLEIA--NTDWMHKYRGSSNLMLLPKN 1546
KV+RNP F L+ D++YF+ IL ++ + E+A N DWM KYRG SNL+LLP +
Sbjct: 17 KVKRNPNFKVLDSEDLAYFRSILSNDEILNSQAPEELASFNQDWMKKYRGQSNLILLPNS 76
Query: 1545 TEEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMNKVLSFDEVSGVLVC 1366
T++VS+I+KYC+ + LAVVPQGGNT LVG SVPVFDE+++++ MNKV FD VSG C
Sbjct: 77 TDKVSKIMKYCNDKKLAVVPQGGNTDLVGASVPVFDEIVLSLRNMNKVRDFDPVSGTFKC 136
Query: 1365 EAGCILENLAAFLDTKGFVMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTVLGLEA 1186
+AG ++ + FL + PLDL ++ +C +GG VSTNAGGL +RYGSLHG VLGLE
Sbjct: 137 DAGVVMRDAHQFLHDHDHIFPLDLPSRNNCQVGGVVSTNAGGLNFLRYGSLHGNVLGLEV 196
Query: 1185 VTANGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPKMSSVNLAFIACKD 1006
V NG ++ + LRKDNTGYDLK LFIG+EG++G+VT VSI+ K ++N F ++
Sbjct: 197 VLPNGEIISNINALRKDNTGYDLKQLFIGAEGTIGVVTGVSIVAAAKPKALNAVFFGIEN 256
Query: 1005 FLSCQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVSSSENFYILIETTGSG 826
F + QKL V+AK L EILSAFEF+D S++ + +L + P+ + NFY+LIET+GS
Sbjct: 257 FDTVQKLFVKAKSELSEILSAFEFMDRGSIECTIEYLKDLPFPLENQHNFYVLIETSGSN 316
Query: 825 ETYDREKLEAFLLKSLEQGLVSDGVIAQDINQASSFWRIREGITEALQKAGACYKYDLSL 646
+ +D EKL AFL + + L+S+G++A+D W R+ + A G YKYD+SL
Sbjct: 317 KRHDDEKLTAFLKDTTDSKLISEGMMAKDKADFDRLWTWRKSVPTACNSYGGMYKYDMSL 376
Query: 645 PVEEIYNIVNDLRGRLD 595
++++Y++ + RL+
Sbjct: 377 QLKDLYSVSAAVTERLN 393
>sp|P94535|GLCD_BACSU Glycolate oxidase subunit glcD OS=Bacillus subtilis
GN=glcD PE=3 SV=1
Length = 470
Score = 169 bits (426), Expect = 1e-040
Identities = 117/360 (32%), Positives = 184/360 (51%), Gaps = 28/360 (7%)
Frame = -1
Query: 1587 KYRGSSNLMLLPKNTEEVSQILKYCDSRSLAVVPQGGNTGLVGGSVPVFDEVIINVGLMN 1408
+Y+ + ++ P+NT+E+S+IL C + +VP+G T L GG+ P +++ MN
Sbjct: 36 QYQSMPDAVIAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMN 95
Query: 1407 KVLSFDEVSGVLVCEAGCILENLAAFLDTKGFVMPLDLGAKGSCHIGGNVSTNAGGLRLI 1228
++L DE + + G I ++ +++KG P D + IGGN++ N+GGLR +
Sbjct: 96 QILEIDEENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGL 155
Query: 1227 RYGSLHGTVLGLEAVTANGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQP 1048
+YG V+GLE V ANG+++ G L KD GYDL LF+GSEG+LGIVT+ + P
Sbjct: 156 KYGVTRDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVP 215
Query: 1047 KMSSVNLAFIACKDFLSCQKLLVEAKRNLGEILSA------FEFLDNNSMDLVLNHLDGV 886
K + K L+ + + A + + +I++A EFLD ++ LV+ +
Sbjct: 216 KPETK-------KTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTL-LVIEDYAKI 267
Query: 885 RNPVSSSENFYILIETTGSGETYDR--EKLEAFLLKSLEQGLVSDGVIAQDINQASSFWR 712
P S+ +LIE G ET +R EK+EA K G AQ +A +
Sbjct: 268 GLPTSAKA--VLLIEQDGPFETVERDMEKIEAICKK----GDAVSVQTAQTEEEAFALTE 321
Query: 711 IREGITEALQK-AGACYKYDLSLPVEEIYNIV---NDLRGRLDGLANVMGYGHLGDGNLH 544
R AL + D ++P EI N+V ND+ + D ++ +GH GDGNLH
Sbjct: 322 ARRSALSALARLKPTTILEDATVPRSEIANMVKAINDIAAKYD--ISICTFGHAGDGNLH 379
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,891,173,716
Number of Sequences: 518415
Number of Extensions: 89891173716
Number of Successful Extensions: 595657870
Number of sequences better than 0.0: 0
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