BLASTX 7.6.2
Query= UN21484 /QuerySize=1471
(1470 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9STN8|SINA4_ARATH E3 ubiquitin-protein ligase SINAT4 OS=Arab... 613 1e-174
sp|Q8S3N1|SINA5_ARATH E3 ubiquitin-protein ligase SINAT5 OS=Arab... 532 2e-150
sp|Q84JL3|SINA3_ARATH E3 ubiquitin-protein ligase SINAT3 OS=Arab... 524 7e-148
sp|Q9M2P4|SINA2_ARATH E3 ubiquitin-protein ligase SINAT2 OS=Arab... 457 1e-127
sp|P93748|SINA1_ARATH Putative E3 ubiquitin-protein ligase SINAT... 451 6e-126
sp|Q86MW9|SINA_SCHMA E3 ubiquitin-protein ligase sina OS=Schisto... 165 8e-040
sp|P61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A OS=Mus ... 163 5e-039
sp|Q7ZVG6|SIAH1_DANRE E3 ubiquitin-protein ligase Siah1 OS=Danio... 163 5e-039
sp|Q920M9|SIAH1_RAT E3 ubiquitin-protein ligase SIAH1 OS=Rattus ... 163 5e-039
sp|Q8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 OS=Homo ... 162 9e-039
sp|Q06985|SIA1B_MOUSE E3 ubiquitin-protein ligase SIAH1B OS=Mus ... 159 6e-038
sp|Q8I147|SINA_DROWI E3 ubiquitin-protein ligase sina OS=Drosoph... 155 1e-036
sp|P61093|SINA_DROER E3 ubiquitin-protein ligase sina OS=Drosoph... 152 7e-036
sp|P21461|SINA_DROME E3 ubiquitin-protein ligase sina OS=Drosoph... 152 7e-036
sp|P29304|SINA_DROVI E3 ubiquitin-protein ligase sina OS=Drosoph... 151 2e-035
sp|Q9I8X5|SIAH2_XENLA E3 ubiquitin-protein ligase siah2 OS=Xenop... 149 5e-035
sp|O43255|SIAH2_HUMAN E3 ubiquitin-protein ligase SIAH2 OS=Homo ... 149 6e-035
sp|Q06986|SIAH2_MOUSE E3 ubiquitin-protein ligase SIAH2 OS=Mus m... 149 6e-035
sp|Q8R4T2|SIAH2_RAT E3 ubiquitin-protein ligase SIAH2 OS=Rattus ... 149 6e-035
sp|Q7SYL3|SIAH2_DANRE E3 ubiquitin-protein ligase Siah2 OS=Danio... 149 8e-035
>sp|Q9STN8|SINA4_ARATH E3 ubiquitin-protein ligase SINAT4 OS=Arabidopsis
thaliana GN=SINAT4 PE=2 SV=1
Length = 327
Score = 613 bits (1579), Expect = 1e-174
Identities = 295/328 (89%), Positives = 303/328 (92%), Gaps = 9/328 (2%)
Frame = +2
Query: 359 METYSMESSTRSSQNDEIHHNGG---TFHFSSTKTHSSAASPTVVTNIVGPT----ATSV 517
MET SME SS +EIH NG ++ FSSTKTH AA+ VVTNIVGPT ATSV
Sbjct: 1 METDSMECV--SSTGNEIHQNGNGHQSYQFSSTKTHGGAAAAAVVTNIVGPTATAPATSV 58
Query: 518 YELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESL 697
YELLECPVCT SMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESL
Sbjct: 59 YELLECPVCTYSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESL 118
Query: 698 ELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHKV 877
ELPCKFYNLGCPEIFPYYSKLKHESLCNFRPY CPYAGSECG+VGDIPFLV+HLRDDHKV
Sbjct: 119 ELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYSCPYAGSECGIVGDIPFLVAHLRDDHKV 178
Query: 878 DMHAGSTFNHRYVKSNPREVENATWMLTVFQCFGQYFCLHFEAFQLGMGPVYMAFLRFMG 1057
DMHAGSTFNHRYVKSNPREVENATWMLTVF CFGQYFCLHFEAFQLGMGPVYMAFLRFMG
Sbjct: 179 DMHAGSTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMGPVYMAFLRFMG 238
Query: 1058 DEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDRK 1237
DEE+ARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDRK
Sbjct: 239 DEEDARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDRK 298
Query: 1238 ELKLRVTGKIWKEQHSPDSGLFMPNLSS 1321
ELKLRVTGKIWKEQHSPDSGL +PNLSS
Sbjct: 299 ELKLRVTGKIWKEQHSPDSGLSIPNLSS 326
>sp|Q8S3N1|SINA5_ARATH E3 ubiquitin-protein ligase SINAT5 OS=Arabidopsis
thaliana GN=SINAT5 PE=1 SV=2
Length = 309
Score = 532 bits (1370), Expect = 2e-150
Identities = 252/307 (82%), Positives = 271/307 (88%), Gaps = 10/307 (3%)
Frame = +2
Query: 401 NDEIHHNGGTFHFSSTKTHSSAASPTVVTNIVGPTATSVYELLECPVCTCSMYPPIHQCH 580
+DEIH FSSTK+ A T ++ P ATSVYELLECPVCT SMYPPIHQCH
Sbjct: 12 DDEIHQK---HQFSSTKSQGGA------TVVISP-ATSVYELLECPVCTNSMYPPIHQCH 61
Query: 581 NGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKL 760
NGHTLCSTCK RVHNRCPTCRQELGDIRCLALEKVAESLELPCK+YNLGC IFPYYSKL
Sbjct: 62 NGHTLCSTCKSRVHNRCPTCRQELGDIRCLALEKVAESLELPCKYYNLGCLGIFPYYSKL 121
Query: 761 KHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHKVDMHAGSTFNHRYVKSNPREVE 940
KHES CNFRPY CPYAGSEC VGDI FLV+HLRDDHKVDMH G TFNHRYVKSNPREVE
Sbjct: 122 KHESQCNFRPYSCPYAGSECAAVGDITFLVAHLRDDHKVDMHTGCTFNHRYVKSNPREVE 181
Query: 941 NATWMLTVFQCFGQYFCLHFEAFQLGMGPVYMAFLRFMGDEEEARSYSYSLEVGGSGRKL 1120
NATWMLTVFQCFGQYFCLHFEAFQLGM PVYMAFLRFMGDE++AR+Y+YSLEVGGSGRK
Sbjct: 182 NATWMLTVFQCFGQYFCLHFEAFQLGMAPVYMAFLRFMGDEDDARNYTYSLEVGGSGRKQ 241
Query: 1121 TWEGTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDRKELKLRVTGKIWKEQHSPDSGL 1300
TWEGTPRS+RDSHRKVRDS+DGLIIQRNMALFFSGGD+KELKLRVTG+IWKEQ +PDSG+
Sbjct: 242 TWEGTPRSVRDSHRKVRDSHDGLIIQRNMALFFSGGDKKELKLRVTGRIWKEQQNPDSGV 301
Query: 1301 FMPNLSS 1321
+ ++ S
Sbjct: 302 CITSMCS 308
>sp|Q84JL3|SINA3_ARATH E3 ubiquitin-protein ligase SINAT3 OS=Arabidopsis
thaliana GN=SINAT3 PE=2 SV=1
Length = 326
Score = 524 bits (1349), Expect = 7e-148
Identities = 248/326 (76%), Positives = 275/326 (84%), Gaps = 4/326 (1%)
Frame = +2
Query: 353 VEMETYSMESSTRSSQNDEIHHNGGTFHFSSTKTHSSAASPTVVTNIVG--PTATSVYEL 526
+++++ S+ + ++EIH + ++ S H++ + V G PT TSV+EL
Sbjct: 1 MDLDSMDCTSTMDVTDDEEIHQDRHSYASVSKHHHTNNNTTNVNAAASGLLPTTTSVHEL 60
Query: 527 LECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESLELP 706
LECPVCT SMYPPIHQCHNGHTLCSTCK RVHNRCPTCRQELGDIRCLALEKVAESLELP
Sbjct: 61 LECPVCTNSMYPPIHQCHNGHTLCSTCKARVHNRCPTCRQELGDIRCLALEKVAESLELP 120
Query: 707 CKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHKVDMH 886
CK +LGCPEIFPYYSKLKHE++CNFRPY CPYAGSEC V GDIPFLV+HLRDDHKVDMH
Sbjct: 121 CKHMSLGCPEIFPYYSKLKHETVCNFRPYSCPYAGSECSVTGDIPFLVAHLRDDHKVDMH 180
Query: 887 AGSTFNHRYVKSNPREVENATWMLTVFQCFGQYFCLHFEAFQLGMGPVYMAFLRFMGDEE 1066
+G TFNHRYVKSNPREVENATWMLTVF CFGQYFCLHFEAFQLGM PVYMAFLRFMGDE
Sbjct: 181 SGCTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMAPVYMAFLRFMGDET 240
Query: 1067 EARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDRKELK 1246
EAR+Y+YSLEVGG GRKL WEGTPRS+RDSHRKVRDS+DGLIIQRNMALFFSGGDRKELK
Sbjct: 241 EARNYNYSLEVGGYGRKLIWEGTPRSVRDSHRKVRDSHDGLIIQRNMALFFSGGDRKELK 300
Query: 1247 LRVTGKIWKEQH--SPDSGLFMPNLS 1318
LRVTG+IWKEQ G +PNLS
Sbjct: 301 LRVTGRIWKEQQQSGEGGGACIPNLS 326
>sp|Q9M2P4|SINA2_ARATH E3 ubiquitin-protein ligase SINAT2 OS=Arabidopsis
thaliana GN=SINAT2 PE=2 SV=1
Length = 308
Score = 457 bits (1175), Expect = 1e-127
Identities = 209/255 (81%), Positives = 225/255 (88%)
Frame = +2
Query: 515 VYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAES 694
VYELLECPVCT MYPPIHQC NGHTLCS CK+RV N CPTCR ELG+IRCLALEKVAES
Sbjct: 54 VYELLECPVCTNLMYPPIHQCPNGHTLCSNCKLRVQNTCPTCRYELGNIRCLALEKVAES 113
Query: 695 LELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK 874
LE+PC++ NLGC +IFPYYSKLKHE C FRPY CPYAGSEC V GDIP LV HL+DDHK
Sbjct: 114 LEVPCRYQNLGCHDIFPYYSKLKHEQHCRFRPYTCPYAGSECSVTGDIPTLVVHLKDDHK 173
Query: 875 VDMHAGSTFNHRYVKSNPREVENATWMLTVFQCFGQYFCLHFEAFQLGMGPVYMAFLRFM 1054
VDMH G TFNHRYVKSNP EVENATWMLTVF CFG+ FCLHFEAFQLGM PVYMAFLRFM
Sbjct: 174 VDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAFLRFM 233
Query: 1055 GDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDR 1234
GDE EA+ +SYSLEVG GRKLTW+G PRSIRDSHRKVRDS DGLII RN+AL+FSGGDR
Sbjct: 234 GDENEAKKFSYSLEVGAHGRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFSGGDR 293
Query: 1235 KELKLRVTGKIWKEQ 1279
+ELKLRVTG+IWKE+
Sbjct: 294 QELKLRVTGRIWKEE 308
>sp|P93748|SINA1_ARATH Putative E3 ubiquitin-protein ligase SINAT1
OS=Arabidopsis thaliana GN=SINAT1 PE=2 SV=1
Length = 305
Score = 451 bits (1160), Expect = 6e-126
Identities = 205/259 (79%), Positives = 225/259 (86%)
Frame = +2
Query: 503 TATSVYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEK 682
++ VYELLECPVCT MYPPIHQC NGHTLCS+CK+RV N CPTCR ELG+IRCLALEK
Sbjct: 47 SSNGVYELLECPVCTNLMYPPIHQCPNGHTLCSSCKLRVQNTCPTCRYELGNIRCLALEK 106
Query: 683 VAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLR 862
VAESLE+PC++ NLGC +IFPYYSKLKHE C FR Y CPYAGSEC V GDIP LV HL+
Sbjct: 107 VAESLEVPCRYQNLGCQDIFPYYSKLKHEQHCRFRSYSCPYAGSECSVTGDIPTLVDHLK 166
Query: 863 DDHKVDMHAGSTFNHRYVKSNPREVENATWMLTVFQCFGQYFCLHFEAFQLGMGPVYMAF 1042
DDHKVDMH G TFNHRYVKSNP EVENATWMLTVF CFG+ FCLHFEAFQLGM PVYMAF
Sbjct: 167 DDHKVDMHDGCTFNHRYVKSNPHEVENATWMLTVFNCFGRQFCLHFEAFQLGMAPVYMAF 226
Query: 1043 LRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMALFFS 1222
LRFMGDE EA+ +SYSLEVG RKLTW+G PRSIRDSHRKVRDS DGLII RN+AL+FS
Sbjct: 227 LRFMGDENEAKKFSYSLEVGAHSRKLTWQGIPRSIRDSHRKVRDSQDGLIIPRNLALYFS 286
Query: 1223 GGDRKELKLRVTGKIWKEQ 1279
G D++ELKLRVTG+IWKE+
Sbjct: 287 GSDKEELKLRVTGRIWKEE 305
>sp|Q86MW9|SINA_SCHMA E3 ubiquitin-protein ligase sina OS=Schistosoma mansoni
GN=SINA PE=1 SV=1
Length = 371
Score = 165 bits (417), Expect = 8e-040
Identities = 91/259 (35%), Positives = 137/259 (52%), Gaps = 9/259 (3%)
Frame = +2
Query: 461 SAASPTVVT----NIVGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNR 628
S+AS TV N ++ + L ECPVC PPI QC +GH +C++C+ ++ +
Sbjct: 98 SSASDTVCNILPHNTSDSSSIDLASLFECPVCMDYALPPIMQCQSGHIVCASCRSKL-SS 156
Query: 629 CPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYA 808
CPTCR L +IR LA+EK+A S+ PCK+ GCPE F Y SK +HE+ C +RPY CP
Sbjct: 157 CPTCRGNLDNIRNLAMEKLASSVLFPCKYSTSGCPETFHYTSKSEHEAACEYRPYDCPCP 216
Query: 809 GSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSNPREVENATWMLTVFQCFGQY 985
G+ C +G++ ++ HL HK + G + + A + + CFG
Sbjct: 217 GASCKWLGELEQVMPHLVHHHKSITTLQGEDI---VFLATDISLPGAVDWVMMQSCFGHS 273
Query: 986 FCLHFEAFQLGMGPVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRK 1165
F L E + ++ A ++ +G ++A + Y LE+ G R+LTWE PRSI D +
Sbjct: 274 FMLVLEKQERVPDQIFFALVQLIGTRKQADQFVYRLELNGHRRRLTWEACPRSIHDGVQS 333
Query: 1166 VRDSNDGLIIQRNMALFFS 1222
+D L+ N A F+
Sbjct: 334 AIAVSDCLVFDSNTAHSFA 352
>sp|P61092|SIA1A_MOUSE E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus
GN=Siah1a PE=1 SV=1
Length = 282
Score = 163 bits (410), Expect = 5e-039
Identities = 93/252 (36%), Positives = 138/252 (54%), Gaps = 10/252 (3%)
Frame = +2
Query: 482 VTNIVGPTATS--VYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELG 655
V + G TA++ + L ECPVC + PPI QC +GH +CS C+ ++ CPTCR LG
Sbjct: 22 VPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLG 80
Query: 656 DIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGD 835
IR LA+EKVA S+ PCK+ + GC P+ K +HE LC FRPY CP G+ C G
Sbjct: 81 SIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGS 140
Query: 836 IPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAF 1009
+ ++ HL HK + G N P V+ W++ + CFG +F L E
Sbjct: 141 LDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQ 196
Query: 1010 QLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDG 1186
+ G + A ++ +G ++A +++Y LE+ G R+LTWE TPRSI + ++D
Sbjct: 197 EKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDC 256
Query: 1187 LIIQRNMALFFS 1222
L+ ++A F+
Sbjct: 257 LVFDTSIAQLFA 268
>sp|Q7ZVG6|SIAH1_DANRE E3 ubiquitin-protein ligase Siah1 OS=Danio rerio GN=siah1
PE=2 SV=2
Length = 282
Score = 163 bits (410), Expect = 5e-039
Identities = 93/252 (36%), Positives = 138/252 (54%), Gaps = 10/252 (3%)
Frame = +2
Query: 482 VTNIVGPTATS--VYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELG 655
V + G TA++ + L ECPVC + PPI QC +GH +CS C+ ++ CPTCR LG
Sbjct: 22 VPTLSGTTASNSDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLG 80
Query: 656 DIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGD 835
IR LA+EKVA S+ PCK+ + GC P+ K +HE LC FRPY CP G+ C G
Sbjct: 81 SIRNLAMEKVANSVLFPCKYASSGCEVTLPHTDKAEHEELCEFRPYSCPCPGASCKWQGS 140
Query: 836 IPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAF 1009
+ ++ HL HK + G N P V+ W++ + CFG +F L E
Sbjct: 141 LDAVMPHLLHQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQ 196
Query: 1010 QLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDG 1186
+ G + A ++ +G ++A +++Y LE+ G R+LTWE TPRSI + ++D
Sbjct: 197 EKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDC 256
Query: 1187 LIIQRNMALFFS 1222
L+ ++A F+
Sbjct: 257 LVFDTSIAQLFA 268
>sp|Q920M9|SIAH1_RAT E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus
GN=Siah1 PE=1 SV=2
Length = 282
Score = 163 bits (410), Expect = 5e-039
Identities = 93/252 (36%), Positives = 138/252 (54%), Gaps = 10/252 (3%)
Frame = +2
Query: 482 VTNIVGPTATS--VYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELG 655
V + G TA++ + L ECPVC + PPI QC +GH +CS C+ ++ CPTCR LG
Sbjct: 22 VPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLG 80
Query: 656 DIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGD 835
IR LA+EKVA S+ PCK+ + GC P+ K +HE LC FRPY CP G+ C G
Sbjct: 81 SIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGS 140
Query: 836 IPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAF 1009
+ ++ HL HK + G N P V+ W++ + CFG +F L E
Sbjct: 141 LDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQ 196
Query: 1010 QLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDG 1186
+ G + A ++ +G ++A +++Y LE+ G R+LTWE TPRSI + ++D
Sbjct: 197 EKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDC 256
Query: 1187 LIIQRNMALFFS 1222
L+ ++A F+
Sbjct: 257 LVFDTSIAQLFA 268
>sp|Q8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 OS=Homo sapiens
GN=SIAH1 PE=1 SV=2
Length = 282
Score = 162 bits (408), Expect = 9e-039
Identities = 93/252 (36%), Positives = 137/252 (54%), Gaps = 10/252 (3%)
Frame = +2
Query: 482 VTNIVGPTATS--VYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELG 655
V + G TA++ + L ECPVC + PPI QC +GH +CS C+ ++ CPTCR LG
Sbjct: 22 VPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLG 80
Query: 656 DIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGD 835
IR LA+EKVA S+ PCK+ + GC P+ K HE LC FRPY CP G+ C G
Sbjct: 81 SIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGS 140
Query: 836 IPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAF 1009
+ ++ HL HK + G N P V+ W++ + CFG +F L E
Sbjct: 141 LDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQ 196
Query: 1010 QLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDG 1186
+ G + A ++ +G ++A +++Y LE+ G R+LTWE TPRSI + ++D
Sbjct: 197 EKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDC 256
Query: 1187 LIIQRNMALFFS 1222
L+ ++A F+
Sbjct: 257 LVFDTSIAQLFA 268
>sp|Q06985|SIA1B_MOUSE E3 ubiquitin-protein ligase SIAH1B OS=Mus musculus
GN=Siah1b PE=2 SV=2
Length = 282
Score = 159 bits (401), Expect = 6e-038
Identities = 89/236 (37%), Positives = 129/236 (54%), Gaps = 8/236 (3%)
Frame = +2
Query: 524 LLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESLEL 703
L ECPVC + PPI QC +GH +CS C+ ++ CPTCR LG IR LA+EKVA S+
Sbjct: 38 LFECPVCFDYVLPPILQCQSGHLVCSNCRPKL-TCCPTCRGPLGSIRNLAVEKVANSVLF 96
Query: 704 PCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK-VD 880
PCK+ GC P+ K +HE LC FRPY CP G+ C G + ++ HL HK +
Sbjct: 97 PCKYSASGCEITLPHTKKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSIT 156
Query: 881 MHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAFQLGMG-PVYMAFLRFM 1054
G N P V+ W++ + CFG +F L E + G + A ++ +
Sbjct: 157 TLQGEDIVFLATDINLPGAVD---WVM-MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLI 212
Query: 1055 GDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMALFFS 1222
G ++A +++Y LE+ G R+LTWE TPRSI + ++D L+ ++A F+
Sbjct: 213 GTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFA 268
>sp|Q8I147|SINA_DROWI E3 ubiquitin-protein ligase sina OS=Drosophila willistoni
GN=sina PE=3 SV=1
Length = 331
Score = 155 bits (390), Expect = 1e-036
Identities = 97/296 (32%), Positives = 151/296 (51%), Gaps = 11/296 (3%)
Frame = +2
Query: 380 SSTRSSQNDEIHHNGGTFHFSSTKTHSSAASPTVVTNIVGPTATSVYELLECPVCTCSMY 559
++T S + + GT ++T + SS++ + G +A + L ECPVC +
Sbjct: 40 TNTTGSSSTGGSSSAGTTSSANTSSSSSSSLSSAGGGDAGMSA-DLTSLFECPVCFDYVL 98
Query: 560 PPIHQCHNGHTLCSTCKVRVHNRCPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEI 739
PPI QC +GH +C +C+ ++ CPTCR L +IR LA+EKVA +++ PCK GC
Sbjct: 99 PPILQCSSGHLVCVSCRSKL-TCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTAS 157
Query: 740 FPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYV 916
Y K +HE C RPY CP G+ C G + ++ HL HK + G
Sbjct: 158 LVYTEKTEHEETCECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLAT 217
Query: 917 KSN-PREVENATWMLTVFQCFGQYFCLHFEAFQLGMG-PVYMAFLRFMGDEEEARSYSYS 1090
N P V+ W++ + CFG +F L E + G + A ++ +G +EA ++ Y
Sbjct: 218 DINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYR 273
Query: 1091 LEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDRKELKLRVT 1258
LE+ G+ R+LTWE PRSI + ++D L+ ++A F+ D L + VT
Sbjct: 274 LELNGNRRRLTWEAMPRSIHEGVASAIHNSDCLVFDTSIAQLFA--DNGNLGINVT 327
>sp|P61093|SINA_DROER E3 ubiquitin-protein ligase sina OS=Drosophila erecta
GN=sina PE=3 SV=1
Length = 314
Score = 152 bits (383), Expect = 7e-036
Identities = 94/283 (33%), Positives = 145/283 (51%), Gaps = 11/283 (3%)
Frame = +2
Query: 419 NGGTFHFSSTKTHSSAASPTVVTNIVGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLC 598
+ G ++T + SS++ + G +A + L ECPVC + PPI QC +GH +C
Sbjct: 36 SAGNTSSANTSSSSSSSLSSAGGGDAGMSA-DLTSLFECPVCFDYVLPPILQCSSGHLVC 94
Query: 599 STCKVRVHNRCPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLC 778
+C+ ++ CPTCR L +IR LA+EKVA +++ PCK GC Y K +HE C
Sbjct: 95 VSCRSKL-TCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEHEETC 153
Query: 779 NFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATW 952
RPY CP G+ C G + ++ HL HK + G N P V+ W
Sbjct: 154 ECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDINLPGAVD---W 210
Query: 953 MLTVFQCFGQYFCLHFEAFQLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWE 1129
++ + CFG +F L E + G + A ++ +G +EA ++ Y LE+ G+ R+LTWE
Sbjct: 211 VM-MQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWE 269
Query: 1130 GTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDRKELKLRVT 1258
PRSI + ++D L+ ++A F+ D L + VT
Sbjct: 270 AMPRSIHEGVASAIHNSDCLVFDTSIAQLFA--DNGNLGINVT 310
>sp|P21461|SINA_DROME E3 ubiquitin-protein ligase sina OS=Drosophila
melanogaster GN=sina PE=1 SV=2
Length = 314
Score = 152 bits (383), Expect = 7e-036
Identities = 94/283 (33%), Positives = 145/283 (51%), Gaps = 11/283 (3%)
Frame = +2
Query: 419 NGGTFHFSSTKTHSSAASPTVVTNIVGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLC 598
+ G ++T + SS++ + G +A + L ECPVC + PPI QC +GH +C
Sbjct: 36 SAGNTSSANTSSSSSSSLSSAGGGDAGMSA-DLTSLFECPVCFDYVLPPILQCSSGHLVC 94
Query: 599 STCKVRVHNRCPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLC 778
+C+ ++ CPTCR L +IR LA+EKVA +++ PCK GC Y K +HE C
Sbjct: 95 VSCRSKL-TCCPTCRGPLANIRNLAMEKVASNVKFPCKHSGYGCTASLVYTEKTEHEETC 153
Query: 779 NFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATW 952
RPY CP G+ C G + ++ HL HK + G N P V+ W
Sbjct: 154 ECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDINLPGAVD---W 210
Query: 953 MLTVFQCFGQYFCLHFEAFQLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWE 1129
++ + CFG +F L E + G + A ++ +G +EA ++ Y LE+ G+ R+LTWE
Sbjct: 211 VM-MQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWE 269
Query: 1130 GTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDRKELKLRVT 1258
PRSI + ++D L+ ++A F+ D L + VT
Sbjct: 270 AMPRSIHEGVASAIHNSDCLVFDTSIAQLFA--DNGNLGINVT 310
>sp|P29304|SINA_DROVI E3 ubiquitin-protein ligase sina OS=Drosophila virilis
GN=sina PE=3 SV=1
Length = 314
Score = 151 bits (379), Expect = 2e-035
Identities = 93/283 (32%), Positives = 145/283 (51%), Gaps = 11/283 (3%)
Frame = +2
Query: 419 NGGTFHFSSTKTHSSAASPTVVTNIVGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLC 598
+ G ++T + SS++ + G +A + L ECPVC + PPI QC +GH +C
Sbjct: 36 SAGNTSSANTSSSSSSSLSSAGGGDAGMSA-DLTSLFECPVCFDYVLPPILQCSSGHLVC 94
Query: 599 STCKVRVHNRCPTCRQELGDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLC 778
+C+ ++ CPTCR L +IR LA+E+VA +++ PCK GC Y K +HE C
Sbjct: 95 VSCRSKL-TCCPTCRGPLANIRNLAMEEVASNVKFPCKHSGYGCTASLVYTEKTEHEETC 153
Query: 779 NFRPYGCPYAGSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATW 952
RPY CP G+ C G + ++ HL HK + G N P V+ W
Sbjct: 154 ECRPYLCPCPGASCKWQGPLDLVMQHLMMSHKSITTLQGEDIVFLATDINLPGAVD---W 210
Query: 953 MLTVFQCFGQYFCLHFEAFQLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWE 1129
++ + CFG +F L E + G + A ++ +G +EA ++ Y LE+ G+ R+LTWE
Sbjct: 211 VM-MQSCFGHHFMLVLEKQEKYDGHQQFFAIVQLIGSRKEAENFVYRLELNGNRRRLTWE 269
Query: 1130 GTPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDRKELKLRVT 1258
PRSI + ++D L+ ++A F+ D L + VT
Sbjct: 270 AMPRSIHEGVASAIHNSDCLVFDTSIAQLFA--DNGNLGINVT 310
>sp|Q9I8X5|SIAH2_XENLA E3 ubiquitin-protein ligase siah2 OS=Xenopus laevis
GN=siah2 PE=2 SV=1
Length = 313
Score = 149 bits (376), Expect = 5e-035
Identities = 95/274 (34%), Positives = 141/274 (51%), Gaps = 15/274 (5%)
Frame = +2
Query: 458 SSAASPTVVTNIVGPTATSVYE---LLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNR 628
S+ +PT I GP + E L ECPVC + PPI QC GH +C+ C+ ++ +
Sbjct: 42 SAPPAPTAAA-ITGPLSQQHQELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SC 99
Query: 629 CPTCRQEL-GDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPY 805
CPTCR L IR LA+EKVA ++ PCK+ + GC + K +HE +C +RPY CP
Sbjct: 100 CPTCRASLTPSIRNLAMEKVASAVLFPCKYASTGCSLSLHHTEKPEHEDICEYRPYSCPC 159
Query: 806 AGSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFG 979
G+ C G + ++ HL HK + G N P V+ W++ + CF
Sbjct: 160 PGASCKWQGSLENVMQHLTHSHKSITTLQGEDIVFLATDINLPGAVD---WVMMQY-CFN 215
Query: 980 QYFCLHFEAFQLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDS 1156
+F L E + G + A + +G ++A +Y+Y LE+ G+ R+LTWE TPRSI D
Sbjct: 216 HHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENYAYRLELNGNRRRLTWEATPRSIHDG 275
Query: 1157 HRKVRDSNDGLIIQRNMALFFSGGDRKELKLRVT 1258
++D L+ +A F+ D L + VT
Sbjct: 276 VAAAIMNSDCLVFDTAIAHLFA--DNGNLGINVT 307
>sp|O43255|SIAH2_HUMAN E3 ubiquitin-protein ligase SIAH2 OS=Homo sapiens
GN=SIAH2 PE=1 SV=1
Length = 324
Score = 149 bits (375), Expect = 6e-035
Identities = 91/259 (35%), Positives = 135/259 (52%), Gaps = 11/259 (4%)
Frame = +2
Query: 494 VGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQEL-GDIRCL 670
V P + L ECPVC + PPI QC GH +C+ C+ ++ + CPTCR L IR L
Sbjct: 67 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTCRGALTPSIRNL 125
Query: 671 ALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLV 850
A+EKVA ++ PCK+ GC + K +HE +C +RPY CP G+ C G + ++
Sbjct: 126 AMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVM 185
Query: 851 SHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAFQLGMG 1024
SHL HK + G N P V+ W++ + CFG +F L E + G
Sbjct: 186 SHLMHAHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYEG 241
Query: 1025 -PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQR 1201
+ A + +G ++A +++Y LE+ G+ R+LTWE TPRSI D ++D L+
Sbjct: 242 HQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDT 301
Query: 1202 NMALFFSGGDRKELKLRVT 1258
+A F+ D L + VT
Sbjct: 302 AIAHLFA--DNGNLGINVT 318
>sp|Q06986|SIAH2_MOUSE E3 ubiquitin-protein ligase SIAH2 OS=Mus musculus
GN=Siah2 PE=1 SV=2
Length = 325
Score = 149 bits (375), Expect = 6e-035
Identities = 91/259 (35%), Positives = 135/259 (52%), Gaps = 11/259 (4%)
Frame = +2
Query: 494 VGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQEL-GDIRCL 670
V P + L ECPVC + PPI QC GH +C+ C+ ++ + CPTCR L IR L
Sbjct: 68 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTCRGALTPSIRNL 126
Query: 671 ALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLV 850
A+EKVA ++ PCK+ GC + K +HE +C +RPY CP G+ C G + ++
Sbjct: 127 AMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVM 186
Query: 851 SHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAFQLGMG 1024
SHL HK + G N P V+ W++ + CFG +F L E + G
Sbjct: 187 SHLMHAHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYEG 242
Query: 1025 -PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQR 1201
+ A + +G ++A +++Y LE+ G+ R+LTWE TPRSI D ++D L+
Sbjct: 243 HQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDT 302
Query: 1202 NMALFFSGGDRKELKLRVT 1258
+A F+ D L + VT
Sbjct: 303 AIAHLFA--DNGNLGINVT 319
>sp|Q8R4T2|SIAH2_RAT E3 ubiquitin-protein ligase SIAH2 OS=Rattus norvegicus
GN=Siah2 PE=1 SV=2
Length = 325
Score = 149 bits (375), Expect = 6e-035
Identities = 91/259 (35%), Positives = 135/259 (52%), Gaps = 11/259 (4%)
Frame = +2
Query: 494 VGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLCSTCKVRVHNRCPTCRQEL-GDIRCL 670
V P + L ECPVC + PPI QC GH +C+ C+ ++ + CPTCR L IR L
Sbjct: 68 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKL-SCCPTCRGALTPSIRNL 126
Query: 671 ALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCNFRPYGCPYAGSECGVVGDIPFLV 850
A+EKVA ++ PCK+ GC + K +HE +C +RPY CP G+ C G + ++
Sbjct: 127 AMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVM 186
Query: 851 SHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWMLTVFQCFGQYFCLHFEAFQLGMG 1024
SHL HK + G N P V+ W++ + CFG +F L E + G
Sbjct: 187 SHLMHAHKSITTLQGEDIVFLATDINLPGAVD---WVM-MQSCFGHHFMLVLEKQEKYEG 242
Query: 1025 -PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEGTPRSIRDSHRKVRDSNDGLIIQR 1201
+ A + +G ++A +++Y LE+ G+ R+LTWE TPRSI D ++D L+
Sbjct: 243 HQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDT 302
Query: 1202 NMALFFSGGDRKELKLRVT 1258
+A F+ D L + VT
Sbjct: 303 AIAHLFA--DNGNLGINVT 319
>sp|Q7SYL3|SIAH2_DANRE E3 ubiquitin-protein ligase Siah2 OS=Danio rerio
GN=siah2l PE=2 SV=2
Length = 331
Score = 149 bits (374), Expect = 8e-035
Identities = 97/282 (34%), Positives = 144/282 (51%), Gaps = 14/282 (4%)
Frame = +2
Query: 425 GTFHFSSTKTHSSAASPTVVTNIVGPTATSVYELLECPVCTCSMYPPIHQCHNGHTLCST 604
G+ S T ++ A P P T+ L ECPVC + PPI QC GH +C+
Sbjct: 56 GSVAGSGTVPAAAVALPVAALPGQSPELTA---LFECPVCFDYVLPPILQCQAGHLVCNQ 112
Query: 605 CKVRVHNRCPTCRQEL-GDIRCLALEKVAESLELPCKFYNLGCPEIFPYYSKLKHESLCN 781
C+ ++ + CPTCR L IR LA+EKVA +L PCK+ + GC + K +HE +C
Sbjct: 113 CRQKL-SCCPTCRGPLTPSIRNLAMEKVASTLPFPCKYSSAGCLLSLHHSEKPEHEEVCE 171
Query: 782 FRPYGCPYAGSECGVVGDIPFLVSHLRDDHK-VDMHAGSTFNHRYVKSN-PREVENATWM 955
FRPY CP G+ C G + ++ HL HK + G N P V+ W+
Sbjct: 172 FRPYTCPCPGASCKWQGSLEEVMPHLMHAHKSITTLQGEDIVFLATDINLPGAVD---WV 228
Query: 956 LTVFQCFGQYFCLHFEAFQLGMG-PVYMAFLRFMGDEEEARSYSYSLEVGGSGRKLTWEG 1132
+ + CFG +F L E + G + A + +G ++A +++Y LE+ G+ R+LTWE
Sbjct: 229 M-MQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEA 287
Query: 1133 TPRSIRDSHRKVRDSNDGLIIQRNMALFFSGGDRKELKLRVT 1258
TPRSI D ++D L+ ++A F+ D L + VT
Sbjct: 288 TPRSIHDGVAAAIMNSDCLVFDTSIAHLFA--DNGNLGINVT 327
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,891,173,716
Number of Sequences: 518415
Number of Extensions: 89891173716
Number of Successful Extensions: 595657870
Number of sequences better than 0.0: 0
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