BLASTX 7.6.2
Query= UN21657 /QuerySize=1718
(1717 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q05047|C72A1_CATRO Secologanin synthase OS=Catharanthus roseu... 539 2e-152
sp|P15129|CP4B1_RAT Cytochrome P450 4B1 OS=Rattus norvegicus GN=... 162 8e-039
sp|O08336|CYPE_BACSU Probable bifunctional P-450/NADPH-P450 redu... 137 3e-031
sp|P79401|CP3AT_PIG Cytochrome P450 3A29 OS=Sus scrofa GN=CYP3A2... 131 3e-029
sp|P24463|CP3AC_CANFA Cytochrome P450 3A12 OS=Canis familiaris G... 124 2e-027
sp|Q27520|C13A1_CAEEL Putative cytochrome P450 CYP13A1 OS=Caenor... 121 2e-026
sp|Q9VYQ7|CP311_DROME Probable cytochrome P450 311a1 OS=Drosophi... 120 5e-026
sp|Q09653|C13AA_CAEEL Putative cytochrome P450 CYP13A10 OS=Caeno... 119 1e-025
sp|O17624|C13B1_CAEEL Putative cytochrome P450 cyp-13B1 OS=Caeno... 116 9e-025
sp|Q9W011|C4D20_DROME Probable cytochrome P450 4d20 OS=Drosophil... 115 2e-024
sp|Q27515|C13A6_CAEEL Putative cytochrome P450 CYP13A6 OS=Caenor... 113 6e-024
sp|Q9SAB6|C71AI_ARATH Cytochrome P450 71A18 OS=Arabidopsis thali... 111 2e-023
sp|Q27518|C13A2_CAEEL Putative cytochrome P450 CYP13A2 OS=Caenor... 111 3e-023
sp|O49340|C71AC_ARATH Cytochrome P450 71A12 OS=Arabidopsis thali... 109 8e-023
sp|Q59990|CP120_SYNY3 Putative cytochrome P450 120 OS=Synechocys... 107 2e-022
sp|O08394|CYPD_BACSU Probable bifunctional P-450/NADPH-P450 redu... 102 1e-020
sp|Q9VQD2|CP391_DROME Probable cytochrome P450 309a1 OS=Drosophi... 84 2e-015
sp|O23365|C97B3_ARATH Cytochrome P450 97B3 OS=Arabidopsis thalia... 73 5e-012
sp|Q8N118|CP4X1_HUMAN Cytochrome P450 4X1 OS=Homo sapiens GN=CYP... 69 1e-010
sp|Q9HCS2|CP4FC_HUMAN Cytochrome P450 4F12 OS=Homo sapiens GN=CY... 66 6e-010
>sp|Q05047|C72A1_CATRO Secologanin synthase OS=Catharanthus roseus GN=CYP72A1
PE=2 SV=1
Length = 524
Score = 539 bits (1388), Expect = 2e-152
Identities = 268/519 (51%), Positives = 362/519 (69%), Gaps = 12/519 (2%)
Frame = -1
Query: 1687 ISVALVTVSLAIVVASWWTWRTLRWVWFKPKMLESYLRSQGLSGSPYTPLIGDLKRTFSM 1508
I A+ A+V+A W WR L W WF PK +E LR QG G+PY L+GD+K + M
Sbjct: 8 IRKAIAATIFALVMA--WAWRVLDWAWFTPKRIEKRLRQQGFRGNPYRFLVGDVKESGKM 65
Query: 1507 AMEARPKPINLSDDISTRVVPFPLEMLKTHGRTYFTWLGTIPTITIMDPELIKEVFNKVY 1328
EA KP+ ++DI R++P + T+GR FTW+G IP I +M+PELIKEV
Sbjct: 66 HQEALSKPMEFNNDIVPRLMPHINHTINTYGRNSFTWMGRIPRIHVMEPELIKEVLTHSS 125
Query: 1327 DFQKPHTF--PLGNVIAKGLANYDGDKWAKHRRIINPAFHLEKIKNMVPAFHQSCSEVVG 1154
+QK PL + G+ +++G KW+KHRRII+PAF LEK+K+M+PAF +++
Sbjct: 126 KYQKNFDVHNPLVKFLLTGVGSFEGAKWSKHRRIISPAFTLEKLKSMLPAFAICYHDMLT 185
Query: 1153 KWDKIVSEKGVSCEVDVWPGLVSMTADVISRTAFGSSYKEGQRIFELQEELAQLIILAVL 974
KW+KI ++G S EVD++P +T+DVIS+ AFGS+Y+EG +IF L +EL L I +
Sbjct: 186 KWEKIAEKQG-SHEVDIFPTFDVLTSDVISKVAFGSTYEEGGKIFRLLKELMDLTIDCMR 244
Query: 973 KAFIPGYLYLPTKGNRRIKAAAKEIQVILKGIVNKRLRAREAGELAPSDDLLGILLESNL 794
+IPG+ YLPTK N+R+K KEI +L+ I+NKR++A +AGE DDLLG+LLESN+
Sbjct: 245 DVYIPGWSYLPTKRNKRMKEINKEITDMLRFIINKRMKALKAGE-PGEDDLLGVLLESNI 303
Query: 793 G--QAKGNK----MSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQAHAREEVK 632
Q +GNK MS DV+EECKLFYFAGQETT VLL WT +LLS+H +WQ AREEV
Sbjct: 304 QEIQKQGNKKDGGMSINDVIEECKLFYFAGQETTGVLLTWTTILLSKHPEWQERAREEVL 363
Query: 631 QVFGDKEPDVEGLNQLKVMMMILYEVLRLYPPVAQLTRAIQKEMKLGDLTLPRGAQISLP 452
Q FG +P+ E LN LK + MILYEVLRLYPPV LT+ + K+ KLG T+P G Q+ LP
Sbjct: 364 QAFGKNKPEFERLNHLKYVSMILYEVLRLYPPVIDLTKIVHKDTKLGSYTIPAGTQVMLP 423
Query: 451 ILLVHRDTQLWGEDAAEFKPERFKDGVSKATNGKVSFFPFAWGPRICIGQSFALLETKMA 272
+++HR+ +WGEDA EF P RF DGV+ AT V++ PF+WGPR+C+GQ+FALL+ K+
Sbjct: 424 TVMLHREKSIWGEDAMEFNPMRFVDGVANATKNNVTYLPFSWGPRVCLGQNFALLQAKLG 483
Query: 271 LALILQRFSFELSPSYVHAPYTVITLHPQFGARLILHKL 155
LA+ILQRF F+++PSYVHAP+T++T+ PQFG+ +I KL
Sbjct: 484 LAMILQRFKFDVAPSYVHAPFTILTVQPQFGSHVIYKKL 522
>sp|P15129|CP4B1_RAT Cytochrome P450 4B1 OS=Rattus norvegicus GN=Cyp4b1 PE=1
SV=3
Length = 511
Score = 162 bits (409), Expect = 8e-039
Identities = 129/436 (29%), Positives = 202/436 (46%), Gaps = 35/436 (8%)
Frame = -1
Query: 1399 WLGT-IPTITIMDPELIKEVFNK-------VYDFQKPHTFPLGNVIAKGLANYDGDKWAK 1244
W G + + I +P+ K V+++ VYDF I KGL DG KW +
Sbjct: 84 WFGQFVGFLNIYEPDYAKAVYSRGDPKAADVYDF-------FLQWIGKGLLVLDGPKWFQ 136
Query: 1243 HRRIINPAFHLEKIKNMVPAFHQSCSEVVGKWDKIVSEKGVSCEVDVWPGLVSMTADVIS 1064
HR+++ P FH + +K V F +S ++ KW+K SE + D++ + M D +
Sbjct: 137 HRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASE---NKSFDIFCDVGHMALDTLM 193
Query: 1063 RTAFGSSYKE-GQRIFELQEELAQLIILAVLK----AFIPGYLYLPTKGNRRIKAAAKEI 899
+ FG G R ++ L +L + + ++Y T RR A K
Sbjct: 194 KCTFGKGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACKIA 253
Query: 898 QVILKGIVNKRLRA------REAGELAPSDDLLGILLESNLGQAKGNKMSTEDVMEECKL 737
++ +R A R+ + D L ILL + G K+S ++ E
Sbjct: 254 HDHTDEVIRQRKAALQDEKERKKIQQRRHLDFLDILL--GVRDESGIKLSDAELRAEVDT 311
Query: 736 FYFAGQETTSVLLVWTMVLLSQHQDWQAHAREEVKQVFGDKEP-DVEGLNQLKVMMMILY 560
F F G +TT+ + W + ++ + + Q REEV+ + GD++ + L ++ + M +
Sbjct: 312 FMFEGHDTTTSGISWFLYCMALYPEHQQLCREEVRGILGDQDSFQWDDLAKMTYLTMCMK 371
Query: 559 EVLRLYPPVAQLTRAIQKEMKLGD-LTLPRGAQISLPILLVHRDTQLWGEDAAEFKPERF 383
E RLYPPV Q+ R + K + D +LP G+ ISL I +HR++ +W D F P RF
Sbjct: 372 ECFRLYPPVPQVYRQLNKPVTFVDGRSLPAGSLISLHIYALHRNSTVW-PDPEVFDPLRF 430
Query: 382 KDGVSKATNGKVSFFPFAWGPRICIGQSFALLETKMALALILQRFSFELSPSYVHAPYTV 203
+ A +F PF+ GPR CIGQ FA+ E K+ AL L RF F L PS +
Sbjct: 431 SP-ENAAGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSLDPSKMPIKVPQ 489
Query: 202 ITLHPQFGARLILHKL 155
+ L + G L L L
Sbjct: 490 LILRSKNGIHLYLKPL 505
>sp|O08336|CYPE_BACSU Probable bifunctional P-450/NADPH-P450 reductase 2
OS=Bacillus subtilis GN=cypE PE=2 SV=1
Length = 1054
Score = 137 bits (344), Expect = 3e-031
Identities = 102/363 (28%), Positives = 168/363 (46%), Gaps = 24/363 (6%)
Frame = -1
Query: 1252 WAKHRRIINPAFHLEKIKNMVPAFHQSCSEVVGKWDKIVSEKGVSCEVDVWPGLVSMTAD 1073
W K RI+ P+F + +K ++++ KW ++ + E+DV + +T D
Sbjct: 98 WQKAHRILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNE----EIDVADDMTRLTLD 153
Query: 1072 VIS----RTAFGSSYKEGQRIFELQEELAQLIILAVLKAFIPGYLYLPTKGNRRIKAA-- 911
I F S Y++ Q F +L LK + L + +K
Sbjct: 154 TIGLCGFNYRFNSFYRDSQHPFITS-------MLRALKEAMNQSKRLGLQDKMMVKTKLQ 206
Query: 910 -AKEIQVILKGIVNKRLRAREAGELAPSDDLLGILLESNLGQAKGNKMSTEDVMEECKLF 734
K+I+V + +V++ + R+A DLL ++L + G + E++ + F
Sbjct: 207 FQKDIEV-MNSLVDRMIAERKANPDENIKDLLSLMLYAK-DPVTGETLDDENIRYQIITF 264
Query: 733 YFAGQETTSVLLVWTMVLLSQHQDWQAHAREEVKQVFGDKEPDVEGLNQLKVMMMILYEV 554
AG ETTS LL + + L H + A+EE +V D P+ + + QLK + M+L E
Sbjct: 265 LIAGHETTSGLLSFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNET 324
Query: 553 LRLYPPVAQLTRAIQKEMKL-GDLTLPRGAQISLPILLVHRDTQLWGEDAAEFKPERFKD 377
LRLYP + +++ L G+ + +G +++ I +HRD WG DA +F+PERF+D
Sbjct: 325 LRLYPTAPAFSLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFED 384
Query: 376 GVSKATNGKVSFFPFAWGPRICIGQSFALLETKMALALILQRFSFELSPSYVHAPYTVIT 197
S + ++ PF G R CIG FAL E M L L+L+ F Y +T
Sbjct: 385 PSSIPHH---AYKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALT 441
Query: 196 LHP 188
+ P
Sbjct: 442 IKP 444
>sp|P79401|CP3AT_PIG Cytochrome P450 3A29 OS=Sus scrofa GN=CYP3A29 PE=2 SV=1
Length = 503
Score = 131 bits (327), Expect = 3e-029
Identities = 74/199 (37%), Positives = 116/199 (58%), Gaps = 5/199 (2%)
Frame = -1
Query: 826 DLLGILLESNLGQAKG--NKMSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQA 653
DLL +++ S + +S E+++ + +F FAG ETTS L L+ H D Q
Sbjct: 270 DLLQLMINSQNSKEMDPHKSLSNEELVAQGIIFIFAGYETTSSALSLLAYELATHPDVQQ 329
Query: 652 HAREEVKQVFGDKEPDV-EGLNQLKVMMMILYEVLRLYPPVAQLTRAIQKEMKLGDLTLP 476
+EE++ F +K P + L Q++ + M++ E LRLYP A+L RA +K++++ + +P
Sbjct: 330 KLQEEIEATFPNKAPPTYDALAQMEYLDMVVNETLRLYPIAARLERACKKDVEIHGVFVP 389
Query: 475 RGAQISLPILLVHRDTQLWGEDAAEFKPERFKDGVSKATNGKVSFFPFAWGPRICIGQSF 296
+G + +P+ ++HRD LW E EF+PERF K T ++ PF GPR CIG F
Sbjct: 390 KGTVVVVPVFVLHRDPDLWPE-PEEFRPERFSK-KHKDTINPYTYLPFGTGPRNCIGMRF 447
Query: 295 ALLETKMALALILQRFSFE 239
AL+ K+AL +LQ FSF+
Sbjct: 448 ALMNMKLALVRVLQNFSFK 466
>sp|P24463|CP3AC_CANFA Cytochrome P450 3A12 OS=Canis familiaris GN=CYP3A12 PE=2
SV=1
Length = 503
Score = 124 bits (311), Expect = 2e-027
Identities = 69/183 (37%), Positives = 106/183 (57%), Gaps = 11/183 (6%)
Frame = -1
Query: 772 MSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQAHAREEVKQVFGDKE-PDVEG 596
+S +++ + +F FAG ETTS L + M L+ H D Q +EE+ F +K P +
Sbjct: 290 LSDLELVAQSIIFIFAGYETTSTSLSFLMYELATHPDVQQKLQEEIDATFPNKALPTYDA 349
Query: 595 LNQLKVMMMILYEVLRLYPPVAQLTRAIQKEMKLGDLTLPRGAQISLPILLVHRDTQLWG 416
L Q++ + M+L E LRLYP +L R +K++++ + +P+G + +P +HRD LW
Sbjct: 350 LVQMEYLDMVLNETLRLYPIAGRLERVCKKDVEISGVFIPKGTVVMVPTFTLHRDQSLWP 409
Query: 415 EDAAEFKPERF----KDGVSKATNGKVSFFPFAWGPRICIGQSFALLETKMALALILQRF 248
E EF+PERF KD ++ T + PF GPR CIG FA++ K+AL +LQ F
Sbjct: 410 E-PEEFRPERFSRKNKDSINPYT-----YLPFGTGPRNCIGMRFAIMNMKLALVRVLQNF 463
Query: 247 SFE 239
SF+
Sbjct: 464 SFK 466
>sp|Q27520|C13A1_CAEEL Putative cytochrome P450 CYP13A1 OS=Caenorhabditis
elegans GN=cyp-13A1 PE=2 SV=1
Length = 519
Score = 121 bits (302), Expect = 2e-026
Identities = 64/180 (35%), Positives = 104/180 (57%), Gaps = 1/180 (0%)
Frame = -1
Query: 775 KMSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQAHAREEVKQVFGDKEPDVEG 596
+++TE+++ +C +F AG +TT++ L + LL+ H + Q +EEV + + E ++
Sbjct: 310 QLTTEEIVGQCTVFLIAGFDTTALSLSYATYLLATHPEIQKKLQEEVNRECPNPEVTIDQ 369
Query: 595 LNQLKVMMMILYEVLRLYPPVA-QLTRAIQKEMKLGDLTLPRGAQISLPILLVHRDTQLW 419
L++LK M + E LRLYP A +R + KLG++ + G I + +H D +W
Sbjct: 370 LSKLKYMECVFKEALRLYPLGAFANSRRCMRNTKLGNMKVEVGTMIQVDTWTLHTDPNIW 429
Query: 418 GEDAAEFKPERFKDGVSKATNGKVSFFPFAWGPRICIGQSFALLETKMALALILQRFSFE 239
G+DA +FKPER++ S K + PF GPR CIG A +E K+ L IL++F+FE
Sbjct: 430 GDDAEDFKPERWQTPNSDQIYQKSGYIPFGLGPRQCIGMRLAYMEEKILLVHILRKFTFE 489
>sp|Q9VYQ7|CP311_DROME Probable cytochrome P450 311a1 OS=Drosophila melanogaster
GN=Cyp311a1 PE=2 SV=1
Length = 483
Score = 120 bits (299), Expect = 5e-026
Identities = 95/372 (25%), Positives = 177/372 (47%), Gaps = 17/372 (4%)
Frame = -1
Query: 1321 QKPHTF-PLGNVIAKGLANYDGDKWAKHRRIINPAFHLEKIKNMVPAFHQSCSEVVGKWD 1145
+K TF L +I GL G W + RR++ PAF + +++ PA +VG
Sbjct: 95 RKADTFMQLEPLIGNGLLISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVG--- 151
Query: 1144 KIVSEKGVSCEVDVWPGLVSMTADVISRTAFGSSYK----EGQRIFELQEELAQLIILAV 977
++ + +G EV L + D I T+ G+ + I + ++L+ +
Sbjct: 152 RLGATRGAFLEVT--EPLFACLLDAIVDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRM 209
Query: 976 LKAFIPG-YLYLPTKGNRRIKAAAKEIQVILKGIVNKRLR-AREAGELA-PSDDLLGILL 806
+ + +++ T+ R + + I ++ ++ KR + + GE A + +LL LL
Sbjct: 210 INPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVIEKRAKELLDMGEPAGRAHNLLDTLL 269
Query: 805 ESNLGQAKGNKMSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQAHAREEVKQV 626
L + +G +S ++ +E F FAG +TT+ + + + L++ + Q R+E++ V
Sbjct: 270 ---LAKFEGQSLSRREIRDEINTFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDV 326
Query: 625 FGDKEPDVEGLNQLKVMMMILYEVLRLYPPVAQLTRAIQKEMKLGDLTLPRGAQISLPIL 446
D+ D++ LN L + ++ EVLRLY V R + ++G T G + + +
Sbjct: 327 ALDETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQTTQSTEIGGRTYCAGVTLWINMY 386
Query: 445 LVHRDTQLWGEDAAEFKPERFKDGVSKATNGKVSFFPFAWGPRICIGQSFALLETKMALA 266
+ D + + D FKPER+ S+ PF+ GP +CIG+ ++LL K+ A
Sbjct: 387 GLAHDKEYY-PDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCIGRRYSLLLMKLLTA 445
Query: 265 LILQRFSFELSP 230
+++ F ELSP
Sbjct: 446 RLVREFQMELSP 457
>sp|Q09653|C13AA_CAEEL Putative cytochrome P450 CYP13A10 OS=Caenorhabditis
elegans GN=cyp-13A10 PE=2 SV=3
Length = 519
Score = 119 bits (296), Expect = 1e-025
Identities = 64/184 (34%), Positives = 108/184 (58%), Gaps = 2/184 (1%)
Frame = -1
Query: 781 GNK-MSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQAHAREEVKQVFGDKEPD 605
GN+ ++T++++ +C +F AG +TT++ L +T LL+ H + Q +EE+++ +
Sbjct: 307 GNRQLTTQEIVGQCLVFLIAGFDTTALSLSYTTFLLATHPEVQKKLQEEIERECIEPSIS 366
Query: 604 VEGLNQLKVMMMILYEVLRLYP-PVAQLTRAIQKEMKLGDLTLPRGAQISLPILLVHRDT 428
+ L++LK M I+ E LRLYP +R + KLG++ + G + + +H DT
Sbjct: 367 FDHLSKLKYMDCIIKETLRLYPLGTMANSRRCMRATKLGNVEVEVGTMVQVDTWSLHTDT 426
Query: 427 QLWGEDAAEFKPERFKDGVSKATNGKVSFFPFAWGPRICIGQSFALLETKMALALILQRF 248
++WG+DA EFKPER+ D K + F GPR C+G A +E KM LA IL+++
Sbjct: 427 KIWGDDAKEFKPERWLDPNCDQVFQKGGYISFGLGPRQCVGMRLAYMEEKMLLAHILRKY 486
Query: 247 SFEL 236
+FE+
Sbjct: 487 TFEV 490
>sp|O17624|C13B1_CAEEL Putative cytochrome P450 cyp-13B1 OS=Caenorhabditis
elegans GN=cyp-13B1 PE=2 SV=2
Length = 527
Score = 116 bits (288), Expect = 9e-025
Identities = 64/183 (34%), Positives = 103/183 (56%), Gaps = 4/183 (2%)
Frame = -1
Query: 793 GQAKGNKMSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQAHAREEVKQVFGDK 614
G K++ EDV+ C +F AG +TT+ L + LL++H + A+EEV V G +
Sbjct: 298 GSTVEKKVTAEDVIGACFVFLLAGFDTTANSLAYASYLLAKHPEKMKLAQEEVDTVVGSE 357
Query: 613 EPDVEGLNQLKVMMMILYEVLRLYPPV-AQLTRAIQKEMKLGDLTLPRGAQISLPILLVH 437
+ + +LK + ++ E LRLYP +R K LGD+ + +G +I ++ +H
Sbjct: 358 NVSYDDMTKLKYLDAVVRESLRLYPVAWFACSRECVKPTTLGDIYIDKGVKIEADVMSLH 417
Query: 436 RDTQLWGEDAAEFKPERFKDGVSKATNGKVSFFPFAWGPRICIGQSFALLETKMALALIL 257
R ++WGE+A +F PER+ + S+ T +S+ PF GPR C+G L E K ALA +L
Sbjct: 418 RSKEIWGENADDFVPERWLEPSSRHT---MSWIPFGAGPRQCVGMRLGLSEAKTALAHLL 474
Query: 256 QRF 248
+R+
Sbjct: 475 RRY 477
>sp|Q9W011|C4D20_DROME Probable cytochrome P450 4d20 OS=Drosophila melanogaster
GN=Cyp4d20 PE=3 SV=1
Length = 510
Score = 115 bits (286), Expect = 2e-024
Identities = 73/204 (35%), Positives = 112/204 (54%), Gaps = 16/204 (7%)
Frame = -1
Query: 823 LLGILLESNLGQAKGNKMSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQAHAR 644
LL ILL+S++ +S D+ EE F F G +TTS + + +++H + Q
Sbjct: 287 LLDILLQSSI---NNQPLSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIF 343
Query: 643 EEVKQVFGDKEPDVEG------LNQLKVMMMILYEVLRLYPPVAQLTRAIQKEMKLGDLT 482
EE+++V G PD L LK + ++ E +RLYPPV + R QKE+++GD T
Sbjct: 344 EELQRVLG---PDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKT 400
Query: 481 LPRGAQISLPILLVHRDTQLWGEDAAEFKPERFKDGVSKATNGKVSFFPFAWGPRICIGQ 302
+P I L + HRD + D F+PERF + + N ++ PF+ GP+ CIGQ
Sbjct: 401 IPANTSIYLVLYYAHRDANYF-PDPLSFRPERFLEDQEQGHN-TFAYVPFSAGPKNCIGQ 458
Query: 301 SFALLETKMALALILQRFSFELSP 230
FA+LE K+ ++ +L RF +EL P
Sbjct: 459 KFAVLEMKVLISKVL-RF-YELLP 480
>sp|Q27515|C13A6_CAEEL Putative cytochrome P450 CYP13A6 OS=Caenorhabditis
elegans GN=cyp-13A6 PE=2 SV=1
Length = 518
Score = 113 bits (281), Expect = 6e-024
Identities = 59/179 (32%), Positives = 100/179 (55%), Gaps = 1/179 (0%)
Frame = -1
Query: 775 KMSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQAHAREEVKQVFGDKEPDVEG 596
+++ ++++ +C +F AG +TT++ L + LL+ H + Q +EEV + D E +
Sbjct: 308 ELTFDEIIAQCFVFLAAGFDTTALSLSYATYLLATHPEIQTKLQEEVDRECPDPEIFFDH 367
Query: 595 LNQLKVMMMILYEVLRLYP-PVAQLTRAIQKEMKLGDLTLPRGAQISLPILLVHRDTQLW 419
L++LK + ++ E LRLYP TR +E + + G I + +H + ++W
Sbjct: 368 LSKLKYLECVMKETLRLYPLGTTANTRKCMRETTINGVNFDEGMNIQVDTWTLHHNPRIW 427
Query: 418 GEDAAEFKPERFKDGVSKATNGKVSFFPFAWGPRICIGQSFALLETKMALALILQRFSF 242
GED +FKPER+++G + S+ PF GPR CIG A +E K+ LA IL+ +SF
Sbjct: 428 GEDVEDFKPERWENGACEHLEHNGSYIPFGSGPRQCIGMRLAQMEQKILLAQILKEYSF 486
>sp|Q9SAB6|C71AI_ARATH Cytochrome P450 71A18 OS=Arabidopsis thaliana GN=CYP71A18
PE=2 SV=2
Length = 497
Score = 111 bits (277), Expect = 2e-023
Identities = 83/301 (27%), Positives = 143/301 (47%), Gaps = 25/301 (8%)
Frame = -1
Query: 1090 VSMTADVISRTAFGSSYKEGQRIFELQEELAQLIILAVLKAFIPGYLYLPTKG------- 932
V++T+DV SR + G Y E + L++ + Q I+ +L+ F G Y+P
Sbjct: 177 VTLTSDVTSRVSLGKKYWEDETAGGLKKRVRQ--IMELLREFPIGD-YVPALAWIDRING 233
Query: 931 -NRRIKAAAKEIQVILKGIVNKRLRAREAGELAPSDDLLGILLESNLGQAKGNKMSTEDV 755
N +I ++ +++ +V + L EAGE D + ILL + G K+ D+
Sbjct: 234 FNSKIVEVSRAYSDLMEKVVQEHL---EAGE--HKADFVNILLSIEKEKNNGFKVQRNDI 288
Query: 754 MEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQAHAREEVKQVFGD-----KEPDVEGLN 590
+ G T+S LL W M L ++ + + E++ KE +VE +
Sbjct: 289 KFMILDMFIGGISTSSTLLEWIMTELIRNPECMKKLQNEIRSTIRPHGSYIKEKEVENMR 348
Query: 589 QLKVMMMILYEVLRLYPPVAQ-LTRAIQKEMKLGDLTLPRGAQISLPILLVHRDTQLWGE 413
LK ++ EV R++PP+ L R + +++K+ + G ++ + +HRD +WG
Sbjct: 349 YLKA---VIKEVFRVHPPLPLILPRLLTEDVKVKGYDIAAGTEVLINAWSIHRDPAIWGP 405
Query: 412 DAAEFKPERFKDGVSKATNGKVSFFPFAWGPRICIGQSFALLETKMALALILQRFSFELS 233
DA EFKPER D + + PF G RIC G + A+ ++ LA ++ RF + +
Sbjct: 406 DAEEFKPERHLDSTLDYHGQDLKYIPFGSGRRICPGINLAMGLVEVTLANLVGRFDWSVD 465
Query: 232 P 230
P
Sbjct: 466 P 466
>sp|Q27518|C13A2_CAEEL Putative cytochrome P450 CYP13A2 OS=Caenorhabditis
elegans GN=cyp-13A2 PE=2 SV=1
Length = 515
Score = 111 bits (275), Expect = 3e-023
Identities = 60/180 (33%), Positives = 98/180 (54%), Gaps = 3/180 (1%)
Frame = -1
Query: 775 KMSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQAHAREEVKQVFGDKEPDVEG 596
++S ++V+ +C LF G +TT++ L + LL+ + Q EE+ + FG E + E
Sbjct: 307 ELSADEVVGQCFLFLIGGFDTTALSLSYVTYLLAVNPKIQEKVIEEIAREFGTSEVEFEK 366
Query: 595 LNQLKVMMMILYEVLRLYPPVA-QLTRAIQKEMKLGDLTLPRGAQISLPILLVHRDTQLW 419
L +LK M ++ E LRLYP + +R K + + + G + + +H D +LW
Sbjct: 367 LGRLKYMDCVIKEALRLYPLASISNSRKCMKTTTVNGVKIEAGVYVQMDTWSLHYDPELW 426
Query: 418 GEDAAEFKPERFKDGVSKATNGKVSFFPFAWGPRICIGQSFALLETKMALALILQRFSFE 239
GED EFKPER+ + K ++ PF GPR CIG A++E K+ L +L+ ++FE
Sbjct: 427 GEDVKEFKPERW--STDEPLEHKGAYLPFGLGPRQCIGMRLAIMEQKILLTHLLKNYTFE 484
>sp|O49340|C71AC_ARATH Cytochrome P450 71A12 OS=Arabidopsis thaliana GN=CYP71A12
PE=2 SV=1
Length = 497
Score = 109 bits (271), Expect = 8e-023
Identities = 83/323 (25%), Positives = 154/323 (47%), Gaps = 22/323 (6%)
Frame = -1
Query: 1177 QSCSEVVGKWDKIVSEKGVSCEVDVWPGLVSMTADVISRTAFGSSYKEGQRIFELQEELA 998
+ +E++ K +K S S ++ V++ +DV SR A G + E + +L++ +
Sbjct: 151 EELNEMIKKLEKASSS---SSSENLSELFVTLPSDVTSRIALGRKHSEDETARDLKKRVR 207
Query: 997 QLIILA---VLKAFIPGYLYLPTKG--NRRIKAAAKEIQVILKGIVNKRLRAREAGELAP 833
Q++ L + ++P ++ N RIK ++ ++ +V + L EAG
Sbjct: 208 QIMELLGEFPIGDYVPALAWIDRINGFNARIKEVSQGFSDLMDKVVQEHL---EAGN--H 262
Query: 832 SDDLLGILLESNLGQAKGNKMSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQA 653
+D + ILL ++ G + +D+ + G T+S LL W M L ++ +
Sbjct: 263 KEDFVDILLSIESEKSIGFQAQRDDIKFMILDMFIGGTSTSSTLLEWIMTELIRNPNVMK 322
Query: 652 HAREEVKQVFGD-----KEPDVEGLNQLKVMMMILYEVLRLYPPVAQ-LTRAIQKEMKLG 491
++E++ KE DVE + LK ++ EV R++PP+ L R + +++K+
Sbjct: 323 KLQDEIRSTIRPHGSYIKEKDVENMKYLKA---VIKEVFRVHPPLPLILPRLLSEDVKVK 379
Query: 490 DLTLPRGAQISLPILLVHRDTQLWGEDAAEFKPERFKDGVSKATNGKVSFFPFAWGPRIC 311
+ G ++ + + RD +WG DA EFKPER D ++F PF G RIC
Sbjct: 380 GYNIAAGTEVIINAWAIQRDPAIWGPDAEEFKPERHLDSTLDYHGKDLNFIPFGSGRRIC 439
Query: 310 IGQSFALLETKMALALILQRFSF 242
G + AL ++ +A ++ RF +
Sbjct: 440 PGINLALGLVEVTVANLVGRFDW 462
>sp|Q59990|CP120_SYNY3 Putative cytochrome P450 120 OS=Synechocystis sp. (strain
PCC 6803) GN=cyp120 PE=1 SV=1
Length = 444
Score = 107 bits (267), Expect = 2e-022
Identities = 79/274 (28%), Positives = 128/274 (46%), Gaps = 6/274 (2%)
Frame = -1
Query: 973 KAFIPGYLYLPTKGNRRIKAAAKEIQVILKGIVNKRLRAREAGELAPS-DDLLGILLESN 797
+ +I G LP + ++ + +L + K ++AR+ + PS +D LGILL +
Sbjct: 175 ETYIQGLFSLPIPLPNTLFGKSQRARALLLAELEKIIKARQ--QQPPSEEDALGILLAAR 232
Query: 796 LGQAKGNKMSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQAHAREEVKQVFGD 617
+S ++ ++ L FAG ET + L +LL QH D + R+E ++
Sbjct: 233 --DDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLS 290
Query: 616 KEPDVEGLNQLKVMMMILYEVLRLYPPVAQLTRAIQKEMKLGDLTLPRGAQISLPILLVH 437
+E E L ++ + +L EVLRL PPV R + ++ + P+G +S I H
Sbjct: 291 QELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTH 350
Query: 436 RDTQLWGEDAAEFKPERFKDGVSKATNGKVSFFPFAWGPRICIGQSFALLETKMALALIL 257
D L+ D +F PERF S N + PF G R C+G+ FA LE K+ ++
Sbjct: 351 ADPDLY-PDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLI 409
Query: 256 QRFSFELSPSYVHAPYTVITLHPQFGARLILHKL 155
Q+F + L P + P+ R+ LH L
Sbjct: 410 QQFDWTLLPGQNLELVVTPSPRPKDNLRVKLHSL 443
>sp|O08394|CYPD_BACSU Probable bifunctional P-450/NADPH-P450 reductase 1
OS=Bacillus subtilis GN=cypD PE=3 SV=1
Length = 1061
Score = 102 bits (252), Expect = 1e-020
Identities = 74/232 (31%), Positives = 111/232 (47%), Gaps = 5/232 (2%)
Frame = -1
Query: 880 IVNKRLRAREAGELAPSDDLLGILLESNLGQAKGNKMSTEDVMEECKLFYFAGQETTSVL 701
+V+ + R A DLL +L G K+ E++ + F AG ETTS L
Sbjct: 217 LVDSIIAERRANGDQDEKDLLARMLNVE-DPETGEKLDDENIRFQIITFLIAGHETTSGL 275
Query: 700 LVWTMVLLSQHQDWQAHAREEVKQVFGDKEPDVEGLNQLKVMMMILYEVLRLYPPVAQLT 521
L + L +H D A EEV +V D P + + +L + MIL E LRL+P +
Sbjct: 276 LSFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAFS 335
Query: 520 RAIQKEMKL-GDLTLPRGAQISLPILLVHRDTQLWGEDAAEFKPERFKDGVSKATNGKVS 344
+++ + G + +IS+ I +HRD WG+DA EF+PERF+ + +
Sbjct: 336 LYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHH---A 392
Query: 343 FFPFAWGPRICIGQSFALLETKMALALILQRFSFELSPSYVHAPYTVITLHP 188
+ PF G R CIG FAL E + L +IL+ F+ +Y +TL P
Sbjct: 393 YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKP 444
>sp|Q9VQD2|CP391_DROME Probable cytochrome P450 309a1 OS=Drosophila melanogaster
GN=Cyp309a1 PE=1 SV=3
Length = 529
Score = 84 bits (207), Expect = 2e-015
Identities = 61/212 (28%), Positives = 96/212 (45%), Gaps = 12/212 (5%)
Frame = -1
Query: 856 REAGELAPSDDLLGILLESNLGQAKGNKMSTEDVMEECKLFYFAGQETTSVLLVWTMVLL 677
R+ G D L L++ Q +GN S D + + G ET+ +L + L
Sbjct: 294 RQGGSGEGRTDYLSHLIQL---QQRGN--SIHDSVGHALTVHLDGFETSGAVLYHMLYSL 348
Query: 676 SQHQDWQAHAREEVKQVFGDK-EPDVEGLNQLKVMMMILYEVLRLYPPVAQLTRAIQK-- 506
S+H + Q R E+ + + + + +N L + E LRL P+ R K
Sbjct: 349 SEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLRLTTPIGFFMRICTKPT 408
Query: 505 EMKLGD---LTLPRGAQISLPILLVHRDTQLWGEDAAEFKPERFKDGVSKATNGKVSFFP 335
++ LGD L L G + +P H D ++ E A+EF+P+RF++G + + F P
Sbjct: 409 QINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPE-ASEFRPDRFENGAASVLTKRGCFLP 467
Query: 334 FAWGPRICIGQSFALLETKMALALILQRFSFE 239
F GPRIC+G L K A+ IL + E
Sbjct: 468 FGDGPRICLGMRVGQLSVKTAIVHILSNYQVE 499
>sp|O23365|C97B3_ARATH Cytochrome P450 97B3 OS=Arabidopsis thaliana GN=CYP97B3
PE=2 SV=2
Length = 580
Score = 73 bits (178), Expect = 5e-012
Identities = 69/286 (24%), Positives = 125/286 (43%), Gaps = 26/286 (9%)
Frame = -1
Query: 1147 DKIVSEKGVSCEVDVWPGLVSMTADVISRTA----FGSSYKEGQRIFELQEELAQLIILA 980
+K S + E+D+ S+ D+I + FGS KE I + L + +
Sbjct: 208 EKETSSGEDTIELDLEAEFSSLALDIIGLSVFNYDFGSVTKESPVIKAVYGTLFEAEHRS 267
Query: 979 VLKAFIPGYLYLPTK----GNRRIKAAAKEIQVILKGIVNKRLRAREAGELAPSDD---- 824
+ P + + P + R+ ++ K I L G++ R+ ++ +
Sbjct: 268 TF--YFPYWNFPPARWIVPRQRKFQSDLKIINDCLDGLIQNAKETRQETDVEKLQERDYT 325
Query: 823 -LLGILLESNLGQAKGNKMSTEDVMEECKLFYFAGQETTSVLLVWTMVLLSQHQDWQAHA 647
L L L +G + + ++ AG ETT+ +L W + LLSQ+ + A
Sbjct: 326 NLKDASLLRFLVDMRGVDIDDRQLRDDLMTMLIAGHETTAAVLTWAVFLLSQNPEKIRKA 385
Query: 646 REEVKQVFGDKEPDVEGLNQLKVMMMILYEVLRLYP-PVAQLTRAIQKEMKLG------- 491
+ E+ V G P E + +L+ + +I+ EVLRL+P P + R ++ E G
Sbjct: 386 QAEIDAVLGQGPPTYESMKKLEYIRLIVVEVLRLFPQPPLLIRRTLKPETLPGGHKGEKE 445
Query: 490 DLTLPRGAQISLPILLVHRDTQLWGEDAAEFKPERFKDGVSKATNG 353
+P+G I + + +HR W ++ +F+PERF +K +NG
Sbjct: 446 GHKVPKGTDIFISVYNLHRSPYFW-DNPHDFEPERFLR--TKESNG 488
>sp|Q8N118|CP4X1_HUMAN Cytochrome P450 4X1 OS=Homo sapiens GN=CYP4X1 PE=2 SV=1
Length = 509
Score = 69 bits (166), Expect = 1e-010
Identities = 40/132 (30%), Positives = 69/132 (52%), Gaps = 9/132 (6%)
Frame = -1
Query: 1435 EMLKTHGRTYFTWLGTIPT-ITIMDPELIKEVFNKV---YDFQKPHTFPLGNVIAKGLAN 1268
E+++ + R + W+G I DP+ K + ++ + + + PL + KGLA
Sbjct: 71 EIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPL---LGKGLAA 127
Query: 1267 YDGDKWAKHRRIINPAFHLEKIKNMVPAFHQSCSEVVGKWDKIVSEKGVSCEVDVWPGLV 1088
DG KW +HRR++ P FH +K + S ++ KW+KI S + S V+V+ +
Sbjct: 128 LDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTS--VEVYEHIN 185
Query: 1087 SMTADVISRTAF 1052
SM+ D+I + AF
Sbjct: 186 SMSLDIIMKCAF 197
>sp|Q9HCS2|CP4FC_HUMAN Cytochrome P450 4F12 OS=Homo sapiens GN=CYP4F12 PE=1
SV=1
Length = 524
Score = 66 bits (160), Expect = 6e-010
Identities = 39/132 (29%), Positives = 70/132 (53%), Gaps = 6/132 (4%)
Frame = -1
Query: 1435 EMLKTHGRTYFTWLG-TIPTITIMDPELIKEVFN-KVYDFQKPHTFP--LGNVIAKGLAN 1268
+M T+ + + WLG IP I + P+ I+ + N K + F L + +G+
Sbjct: 79 QMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILL 138
Query: 1267 YDGDKWAKHRRIINPAFHLEKIKNMVPAFHQSCSEVVGKWDKIVSEKGVSCEVDVWPGLV 1088
GDKW++HRR++ PAFH +K+ + F++S + ++ KW + SE S +D++ +
Sbjct: 139 SGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEG--SSRLDMFEHIS 196
Query: 1087 SMTADVISRTAF 1052
MT D + + F
Sbjct: 197 LMTLDSLQKCIF 208
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,891,173,716
Number of Sequences: 518415
Number of Extensions: 89891173716
Number of Successful Extensions: 595657870
Number of sequences better than 0.0: 0
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