BLASTX 7.6.2
Query= UN21765 /QuerySize=1917
(1916 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q54Z26|GLYC1_DICDI Serine hydroxymethyltransferase 1 OS=Dicty... 515 4e-145
sp|P34899|GLYM_PEA Serine hydroxymethyltransferase, mitochondria... 366 6e-100
sp|P50433|GLYM_SOLTU Serine hydroxymethyltransferase, mitochondr... 365 7e-100
sp|Q9SZJ5|GLYM_ARATH Serine hydroxymethyltransferase, mitochondr... 364 2e-099
sp|P49357|GLYM_FLAPR Serine hydroxymethyltransferase 1, mitochon... 361 1e-098
sp|P49358|GLYN_FLAPR Serine hydroxymethyltransferase 2, mitochon... 361 1e-098
sp|P34896|GLYC_HUMAN Serine hydroxymethyltransferase, cytosolic ... 354 2e-096
sp|Q5RFK5|GLYC_PONAB Serine hydroxymethyltransferase, cytosolic ... 353 4e-096
sp|P50432|GLYC_CAEEL Serine hydroxymethyltransferase OS=Caenorha... 350 3e-095
sp|Q5E9P9|GLYC_BOVIN Serine hydroxymethyltransferase, cytosolic ... 349 4e-095
sp|P35623|GLYC_SHEEP Serine hydroxymethyltransferase, cytosolic ... 348 9e-095
sp|O13972|GLYD_SCHPO Probable serine hydroxymethyltransferase, c... 348 1e-094
sp|P07511|GLYC_RABIT Serine hydroxymethyltransferase, cytosolic ... 347 2e-094
sp|P50431|GLYC_MOUSE Serine hydroxymethyltransferase, cytosolic ... 347 2e-094
sp|O13426|GLYC_CANAL Serine hydroxymethyltransferase, cytosolic ... 346 4e-094
sp|Q60V73|GLYC_CAEBR Serine hydroxymethyltransferase OS=Caenorha... 346 6e-094
sp|Q10104|GLYC_SCHPO Probable serine hydroxymethyltransferase, c... 345 1e-093
sp|P34897|GLYM_HUMAN Serine hydroxymethyltransferase, mitochondr... 343 4e-093
sp|Q3SZ20|GLYM_BOVIN Serine hydroxymethyltransferase, mitochondr... 342 5e-093
sp|P14519|GLYM_RABIT Serine hydroxymethyltransferase, mitochondr... 341 2e-092
>sp|Q54Z26|GLYC1_DICDI Serine hydroxymethyltransferase 1 OS=Dictyostelium
discoideum GN=shmt1 PE=1 SV=1
Length = 457
Score = 515 bits (1326), Expect = 4e-145
Identities = 257/453 (56%), Positives = 336/453 (74%), Gaps = 15/453 (3%)
Frame = +1
Query: 379 EVDPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNE 558
EVD E+ E++ +EK+RQF+ LELIASENFTSRAVME +GS TNKY+EG PG RYYGG E
Sbjct: 12 EVDNEIFELMNREKDRQFKGLELIASENFTSRAVMEALGSHFTNKYAEGYPGSRYYGGTE 71
Query: 559 FIDQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGG 738
+D+L TLCQ RAL FRLD +KWGVNVQP SGSPANFAVYTA+L+PHDRIMGLDLP GG
Sbjct: 72 VVDELETLCQKRALKAFRLDESKWGVNVQPYSGSPANFAVYTALLRPHDRIMGLDLPSGG 131
Query: 739 HLSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSR 918
HL+HG+ T K+++S +SI+FESMPY++ + G++DY LE+ A LF+PKLII+GASAY R
Sbjct: 132 HLTHGYQTDKKKISASSIFFESMPYQIG-ADGLIDYQRLEENALLFKPKLIISGASAYPR 190
Query: 919 DFDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMI 1098
++DY RMR IAD VGA+LM DMAH SGLVAA ++ PF+YCD+VT+TTHK+LRGPR G+I
Sbjct: 191 EWDYKRMRAIADKVGAYLMCDMAHYSGLVAAQLLDSPFDYCDVVTSTTHKTLRGPRSGII 250
Query: 1099 FFKK--------DPVNGVELESAINNAVFPGLQGGPHNHTIGGLAVCLKHAQSPEFKAYQ 1254
FF++ + ++ES IN AVFP LQGGPH + I G+AV LK A S EFK Y
Sbjct: 251 FFRRGKRVDGNGKEIEEYDIESKINFAVFPSLQGGPHENVIAGVAVALKEADSQEFKEYA 310
Query: 1255 KRVVANCRALANRLVELGFDLVSGGSDNHLVLVDLRPLGMDGARVEKILDMASITLNKNS 1434
+V N A+ N L+ G+ LV+ G+DNHL+L DLRP + G + EK D+A+IT+NKN+
Sbjct: 311 LQVKKNAAAIGNALMNKGYKLVTNGTDNHLILWDLRPKELTGNKFEKAADIANITVNKNA 370
Query: 1435 VPGDKSALVPGGIRIGTPAMTTRGLTEKDFVVVADLIKEGVEITMEAKKLVSGSKLGEFT 1614
V GD +A+ PGGIRIG+ A+T+RGL E DF +AD + V I++E + V G KL +F
Sbjct: 371 VHGDTNAISPGGIRIGSSALTSRGLKEADFEKIADFLDRIVSISLEIQGRV-GKKLVDFV 429
Query: 1615 KLVTSPDFALKEKVESLKERVESFTSRFPIPGV 1713
+ +++ L++ VE F+S+F +PG+
Sbjct: 430 VEINK-----SKELLDLRKEVEEFSSKFTLPGI 457
>sp|P34899|GLYM_PEA Serine hydroxymethyltransferase, mitochondrial OS=Pisum
sativum PE=1 SV=1
Length = 518
Score = 366 bits (937), Expect = 6e-100
Identities = 172/243 (70%), Positives = 202/243 (83%)
Frame = +1
Query: 382 VDPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNEF 561
+DPE+ +II+ EK RQ++ LELI SENFTS +VM+ VGS +TNKYSEG PG RYYGGNE+
Sbjct: 59 IDPEIADIIELEKARQWKGLELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEY 118
Query: 562 IDQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGGH 741
ID TLCQ RAL FRLD KWGVNVQPLSGSP+NF VYTA+LKPHDRIM LDLPHGGH
Sbjct: 119 IDMAETLCQKRALEAFRLDPAKWGVNVQPLSGSPSNFQVYTALLKPHDRIMALDLPHGGH 178
Query: 742 LSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSRD 921
LSHG+ T +++S SI+FE+MPYRLDESTG +DYD LEK+A LFRPKLI+AGASAY+R
Sbjct: 179 LSHGYQTDTKKISAVSIFFETMPYRLDESTGYIDYDQLEKSATLFRPKLIVAGASAYARL 238
Query: 922 FDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMIF 1101
+DY R+RK+ D A L+ DMAHISGLVAA V+ PF+Y D+VTTTTHKSLRGPRG MIF
Sbjct: 239 YDYARIRKVCDKQKAVLLADMAHISGLVAAGVIPSPFDYADVVTTTTHKSLRGPRGAMIF 298
Query: 1102 FKK 1110
F+K
Sbjct: 299 FRK 301
>sp|P50433|GLYM_SOLTU Serine hydroxymethyltransferase, mitochondrial OS=Solanum
tuberosum PE=2 SV=1
Length = 518
Score = 365 bits (936), Expect = 7e-100
Identities = 184/294 (62%), Positives = 222/294 (75%), Gaps = 1/294 (0%)
Frame = +1
Query: 232 QQLNFNFPRPVRSLSLKRSLVAERRASPVSVPAVESSSDAIPFEDYGRSE-VDPEVDEII 408
++L+ +PV+SL SL +V E S A P + E VDPE+ +II
Sbjct: 8 RRLSATVDKPVKSLYNGGSLYYMSSLPNEAVYDKEKSGVAWPKQLNAPLEVVDPEIADII 67
Query: 409 KKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNEFIDQL*TLCQ 588
+ EK RQ++ LELI SENFTS +VM+ VGS +TNKYSEG PG RYYGGNE+ID TLCQ
Sbjct: 68 EHEKARQWKGLELIPSENFTSVSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMAETLCQ 127
Query: 589 NRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGGHLSHGFMTAK 768
RAL FRLD KWGVNVQPLSGSPANF VYTA+LKPH+RIM LDLPHGGHLSHG+ T
Sbjct: 128 KRALEAFRLDPAKWGVNVQPLSGSPANFQVYTALLKPHERIMALDLPHGGHLSHGYQTDT 187
Query: 769 RRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSRDFDYPRMRKI 948
+++S SI+FE+MPYRLDESTG +DYD LEK+A LFRPKLI+AGASAY+R +DY R+RK+
Sbjct: 188 KKISAVSIFFETMPYRLDESTGYIDYDQLEKSATLFRPKLIVAGASAYARLYDYDRIRKV 247
Query: 949 ADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMIFFKK 1110
+ A L+ DMAHISGLVAA V+ PF+Y D+VTTTTHKSLRGPRG MIF++K
Sbjct: 248 CNKQKAILLADMAHISGLVAAGVIPSPFDYADVVTTTTHKSLRGPRGAMIFYRK 301
>sp|Q9SZJ5|GLYM_ARATH Serine hydroxymethyltransferase, mitochondrial
OS=Arabidopsis thaliana GN=SHM1 PE=1 SV=1
Length = 517
Score = 364 bits (932), Expect = 2e-099
Identities = 171/244 (70%), Positives = 204/244 (83%)
Frame = +1
Query: 379 EVDPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNE 558
EVDPE+ +II+ EK RQ++ LELI SENFTS +VM+ VGS +TNKYSEG PG RYYGGNE
Sbjct: 57 EVDPEIADIIEHEKARQWKGLELIPSENFTSVSVMQAVGSVMTNKYSEGYPGARYYGGNE 116
Query: 559 FIDQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGG 738
+ID TLCQ RAL FRLD KWGVNVQPLSGSPANF VYTA+LKPH+RIM LDLPHGG
Sbjct: 117 YIDMAETLCQKRALEAFRLDPEKWGVNVQPLSGSPANFHVYTALLKPHERIMALDLPHGG 176
Query: 739 HLSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSR 918
HLSHG+ T +++S SI+FE+MPYRLDESTG +DYD +EK+A LFRPKLI+AGASAY+R
Sbjct: 177 HLSHGYQTDTKKISAVSIFFETMPYRLDESTGYIDYDQMEKSATLFRPKLIVAGASAYAR 236
Query: 919 DFDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMI 1098
+DY R+RK+ + A ++ DMAHISGLVAA+V+ PF+Y D+VTTTTHKSLRGPRG MI
Sbjct: 237 LYDYARIRKVCNKQKAVMLADMAHISGLVAANVIPSPFDYADVVTTTTHKSLRGPRGAMI 296
Query: 1099 FFKK 1110
FF+K
Sbjct: 297 FFRK 300
>sp|P49357|GLYM_FLAPR Serine hydroxymethyltransferase 1, mitochondrial
OS=Flaveria pringlei PE=2 SV=1
Length = 517
Score = 361 bits (926), Expect = 1e-098
Identities = 171/243 (70%), Positives = 201/243 (82%)
Frame = +1
Query: 382 VDPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNEF 561
VDPE+ +II+ EK RQ++ LELI SENFTS +VM+ VGS +TNKYSEG PG RYYGGNE+
Sbjct: 59 VDPEIADIIELEKARQWKGLELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEY 118
Query: 562 IDQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGGH 741
ID TLCQ RAL FRLD KWGVNVQPLSGSPANF VYTA+LK HDRIM LDLPHGGH
Sbjct: 119 IDMAETLCQKRALEAFRLDPAKWGVNVQPLSGSPANFHVYTALLKAHDRIMALDLPHGGH 178
Query: 742 LSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSRD 921
LSHG+ T +++S SI+FE+MPYRL+ESTG +DYD LEK+A LFRPKLI+AGASAY+R
Sbjct: 179 LSHGYQTDTKKISAVSIFFETMPYRLNESTGYIDYDQLEKSATLFRPKLIVAGASAYARL 238
Query: 922 FDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMIF 1101
+DY R+RK+ D A ++ DMAHISGLVAA V+ PF+Y D+VTTTTHKSLRGPRG MIF
Sbjct: 239 YDYARIRKVCDKQKAIMLADMAHISGLVAAGVIPSPFDYADVVTTTTHKSLRGPRGAMIF 298
Query: 1102 FKK 1110
F+K
Sbjct: 299 FRK 301
>sp|P49358|GLYN_FLAPR Serine hydroxymethyltransferase 2, mitochondrial
OS=Flaveria pringlei PE=2 SV=1
Length = 517
Score = 361 bits (926), Expect = 1e-098
Identities = 171/242 (70%), Positives = 201/242 (83%)
Frame = +1
Query: 385 DPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNEFI 564
DPE+ +II+ EK RQ++ LELI SENFTS +VM+ VGS +TNKYSEG PG RYYGGNE+I
Sbjct: 60 DPEIADIIELEKARQWKGLELILSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEYI 119
Query: 565 DQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGGHL 744
D TLCQ RAL FRLD+ KWGVNVQPLSGSPANF VYTA+LK HDRIM LDLPHGGHL
Sbjct: 120 DMAETLCQKRALEAFRLDAAKWGVNVQPLSGSPANFHVYTALLKAHDRIMALDLPHGGHL 179
Query: 745 SHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSRDF 924
SHG+ T +++S SI+FE+MPYRL+ESTG +DYD LEK+A LFRPKLI+AGASAY+R +
Sbjct: 180 SHGYQTDTKKISAVSIFFETMPYRLNESTGYIDYDQLEKSATLFRPKLIVAGASAYARLY 239
Query: 925 DYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMIFF 1104
DY R+RK+ D A L+ DMAHISGLVAA V+ PF+Y D+VTTTTHKSLRGPRG MIFF
Sbjct: 240 DYARIRKVCDKQKAILLADMAHISGLVAAGVIPSPFDYADVVTTTTHKSLRGPRGAMIFF 299
Query: 1105 KK 1110
+K
Sbjct: 300 RK 301
>sp|P34896|GLYC_HUMAN Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens
GN=SHMT1 PE=1 SV=1
Length = 483
Score = 354 bits (906), Expect = 2e-096
Identities = 173/255 (67%), Positives = 203/255 (79%), Gaps = 5/255 (1%)
Frame = +1
Query: 385 DPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNEFI 564
D EV IIKKE NRQ LELIASENF SRAV+E +GSCL NKYSEG PG+RYYGG EFI
Sbjct: 30 DVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFI 89
Query: 565 DQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGGHL 744
D+L TLCQ RAL ++LD WGVNVQP SGSPANFAVYTA+++PH RIMGLDLP GGHL
Sbjct: 90 DELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHL 149
Query: 745 SHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSRDF 924
+HGFMT K+++S TSI+FESMPY+++ TG ++YD LE+ A LF PKLIIAG S YSR+
Sbjct: 150 THGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNL 209
Query: 925 DYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMIFF 1104
+Y R+RKIAD GA+LM DMAHISGLVAA VV PFE+C +VTTTTHK+LRG R GMIF+
Sbjct: 210 EYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFY 269
Query: 1105 KK-----DPVNGVEL 1134
+K DP G E+
Sbjct: 270 RKGVKSVDPKTGKEI 284
>sp|Q5RFK5|GLYC_PONAB Serine hydroxymethyltransferase, cytosolic OS=Pongo abelii
GN=SHMT1 PE=2 SV=1
Length = 483
Score = 353 bits (904), Expect = 4e-096
Identities = 172/255 (67%), Positives = 202/255 (79%), Gaps = 5/255 (1%)
Frame = +1
Query: 385 DPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNEFI 564
D EV IIKKE NRQ LEL ASENF S+AV+E +GSCL NKYSEG PG+RYYGG EFI
Sbjct: 30 DVEVYNIIKKESNRQRVGLELFASENFASQAVLEALGSCLNNKYSEGYPGQRYYGGTEFI 89
Query: 565 DQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGGHL 744
D+L TLCQ RAL ++LD WGVNVQP SGSPANFAVYTA+++PH RIMGLDLP GGHL
Sbjct: 90 DELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHL 149
Query: 745 SHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSRDF 924
+HGFMT K+++S TSI+FESMPY+++ TG ++YD LE+ A LF PKLIIAG S YSR+
Sbjct: 150 THGFMTGKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNL 209
Query: 925 DYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMIFF 1104
DY R+RKIAD GA+LM DMAHISGLVAA VV PFE+C +VTTTTHK+LRG R GMIF+
Sbjct: 210 DYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFY 269
Query: 1105 KK-----DPVNGVEL 1134
+K DP G E+
Sbjct: 270 RKGVQSVDPKTGKEI 284
>sp|P50432|GLYC_CAEEL Serine hydroxymethyltransferase OS=Caenorhabditis elegans
GN=mel-32 PE=1 SV=2
Length = 507
Score = 350 bits (896), Expect = 3e-095
Identities = 168/244 (68%), Positives = 197/244 (80%)
Frame = +1
Query: 379 EVDPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNE 558
+VDPEV +I+K EK RQ R LELIASENFTS+AVM+ +GS + NKYSEG PG RYYGGNE
Sbjct: 54 KVDPEVFDIMKNEKKRQRRGLELIASENFTSKAVMDALGSAMCNKYSEGYPGARYYGGNE 113
Query: 559 FIDQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGG 738
FIDQ+ LCQ RAL F LD KWGVNVQPLSGSPANFAVYTAI+ + RIMGLDLP GG
Sbjct: 114 FIDQMELLCQKRALEVFGLDPAKWGVNVQPLSGSPANFAVYTAIVGSNGRIMGLDLPDGG 173
Query: 739 HLSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSR 918
HL+HGF T R+VS TS +F+S+PY++D +TG++DYD LE+ A LFRPK IIAG S Y+R
Sbjct: 174 HLTHGFFTPARKVSATSEFFQSLPYKVDPTTGLIDYDKLEQNAMLFRPKAIIAGVSCYAR 233
Query: 919 DFDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMI 1098
DY R RKIA GA+LM DMAHISGLVAA ++ PFEY D+VTTTTHKSLRGPRG +I
Sbjct: 234 HLDYERFRKIATKAGAYLMSDMAHISGLVAAGLIPSPFEYSDVVTTTTHKSLRGPRGALI 293
Query: 1099 FFKK 1110
F++K
Sbjct: 294 FYRK 297
>sp|Q5E9P9|GLYC_BOVIN Serine hydroxymethyltransferase, cytosolic OS=Bos taurus
GN=SHMT1 PE=2 SV=3
Length = 484
Score = 349 bits (895), Expect = 4e-095
Identities = 171/254 (67%), Positives = 201/254 (79%), Gaps = 5/254 (1%)
Frame = +1
Query: 385 DPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNEFI 564
D EV IIKKE NRQ LELIASENF SRAV+E +GSCL NKYSEG PG+RYYGG EFI
Sbjct: 30 DVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFI 89
Query: 565 DQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGGHL 744
D+L LCQ RAL + LDS WGVNVQP SGSPANFAVYTA+++PH RIMGLDLP GGHL
Sbjct: 90 DELEVLCQKRALQVYGLDSQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHL 149
Query: 745 SHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSRDF 924
+HGFMT K+++S TSI+FESMPY+++ TG ++YD LE+ A LF P+LIIAG S YSR+
Sbjct: 150 THGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPRLIIAGTSCYSRNL 209
Query: 925 DYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMIFF 1104
DY R+RKIAD GA+LM DMAH+SGLVAA VV PFE+C +V+TTTHK+LRG R GMIF+
Sbjct: 210 DYARLRKIADDNGAYLMADMAHVSGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAGMIFY 269
Query: 1105 KK-----DPVNGVE 1131
+K DP G E
Sbjct: 270 RKGVRSVDPKTGRE 283
>sp|P35623|GLYC_SHEEP Serine hydroxymethyltransferase, cytosolic OS=Ovis aries
GN=SHMT1 PE=1 SV=3
Length = 484
Score = 348 bits (892), Expect = 9e-095
Identities = 171/254 (67%), Positives = 200/254 (78%), Gaps = 5/254 (1%)
Frame = +1
Query: 385 DPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNEFI 564
D EV IIKKE NRQ LELIASENF SRAV+E +GSCL NKYSEG PG+RYYGG EFI
Sbjct: 30 DVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFI 89
Query: 565 DQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGGHL 744
D+L LCQ RAL + LD WGVNVQP SGSPANFAVYTA+++PH RIMGLDLP GGHL
Sbjct: 90 DELEVLCQKRALQVYGLDPECWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHL 149
Query: 745 SHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSRDF 924
+HGFMT K+++S TSI+FESMPY+++ TG ++YD LE+ A LF P+LIIAG S YSR+
Sbjct: 150 THGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPRLIIAGTSCYSRNL 209
Query: 925 DYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMIFF 1104
DY R+RKIAD GA+LM DMAHISGLVAA VV PFE+C +V+TTTHK+LRG R GMIF+
Sbjct: 210 DYARLRKIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVSTTTHKTLRGCRAGMIFY 269
Query: 1105 KK-----DPVNGVE 1131
+K DP G E
Sbjct: 270 RKGVRSVDPKTGKE 283
>sp|O13972|GLYD_SCHPO Probable serine hydroxymethyltransferase, cytosolic
OS=Schizosaccharomyces pombe GN=SPAC24C9.12c PE=2 SV=1
Length = 467
Score = 348 bits (891), Expect = 1e-094
Identities = 166/244 (68%), Positives = 198/244 (81%)
Frame = +1
Query: 379 EVDPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNE 558
E DP V EI++ E +RQ S+ LIASENFTSRAVM+ +GS ++NKYSEG PG RYYGGN+
Sbjct: 14 EQDPTVAEIMRHEADRQRSSVVLIASENFTSRAVMDALGSVMSNKYSEGYPGARYYGGNK 73
Query: 559 FIDQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGG 738
FIDQ+ TLCQ RALA F LD KWGVNVQ LSGSPAN VY AI+ PH R+MGLDLP GG
Sbjct: 74 FIDQIETLCQERALAAFNLDPAKWGVNVQCLSGSPANMQVYQAIMPPHGRLMGLDLPSGG 133
Query: 739 HLSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSR 918
HLSHG+ T +++S S YFESMPYR+D +TG++DYDMLE A LFRPK+++AG SAY R
Sbjct: 134 HLSHGYQTDTKKISAVSTYFESMPYRVDPNTGLIDYDMLEHDAQLFRPKILVAGTSAYCR 193
Query: 919 DFDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMI 1098
DY RMR+IADSV A+L++DMAHISGLV+A V+ PFEY D+VTTTTHKSLRGPRG MI
Sbjct: 194 LIDYARMRQIADSVNAYLVVDMAHISGLVSAGVIPSPFEYADVVTTTTHKSLRGPRGAMI 253
Query: 1099 FFKK 1110
FF++
Sbjct: 254 FFRR 257
>sp|P07511|GLYC_RABIT Serine hydroxymethyltransferase, cytosolic OS=Oryctolagus
cuniculus GN=SHMT1 PE=1 SV=2
Length = 484
Score = 347 bits (890), Expect = 2e-094
Identities = 171/255 (67%), Positives = 200/255 (78%), Gaps = 5/255 (1%)
Frame = +1
Query: 385 DPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNEFI 564
D EV +IIKKE NRQ LELIASENF SRAV+E +GSCL NKYSEG PG+RYYGG E I
Sbjct: 30 DAEVYDIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEHI 89
Query: 565 DQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGGHL 744
D+L TLCQ RAL + LD WGVNVQP SGSPANFAVYTA+++PH RIMGLDLP GGHL
Sbjct: 90 DELETLCQKRALQAYGLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHL 149
Query: 745 SHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSRDF 924
+HGFMT K+++S TSI+FESM Y+++ TG +DYD LE+ A LF PKLIIAG S YSR+
Sbjct: 150 THGFMTDKKKISATSIFFESMAYKVNPDTGYIDYDRLEENARLFHPKLIIAGTSCYSRNL 209
Query: 925 DYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMIFF 1104
DY R+RKIAD GA+LM DMAHISGLV A VV PFE+C +VTTTTHK+LRG R GMIF+
Sbjct: 210 DYGRLRKIADENGAYLMADMAHISGLVVAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFY 269
Query: 1105 KK-----DPVNGVEL 1134
++ DP G E+
Sbjct: 270 RRGVRSVDPKTGKEI 284
>sp|P50431|GLYC_MOUSE Serine hydroxymethyltransferase, cytosolic OS=Mus musculus
GN=Shmt1 PE=1 SV=2
Length = 478
Score = 347 bits (889), Expect = 2e-094
Identities = 172/254 (67%), Positives = 199/254 (78%), Gaps = 5/254 (1%)
Frame = +1
Query: 385 DPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNEFI 564
D EV IIKKE NRQ LELIASENF SRAV+E +GS L NKYSEG PG+RYYGG EFI
Sbjct: 24 DAEVYSIIKKESNRQRVGLELIASENFASRAVLEALGSSLNNKYSEGYPGQRYYGGTEFI 83
Query: 565 DQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGGHL 744
D+L LCQ RAL + LD WGVNVQP SGSPANFAVYTA+++PH RIMGLDLP GGHL
Sbjct: 84 DELEMLCQKRALQAYHLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHL 143
Query: 745 SHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSRDF 924
+HGFMT K+++S TSI+FESMPY++ TG ++YD LE+ A+LF PKLIIAG S YSR+
Sbjct: 144 THGFMTDKKKISATSIFFESMPYKVYPETGYINYDQLEENASLFHPKLIIAGTSCYSRNL 203
Query: 925 DYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMIFF 1104
DY R+RKIAD GA+LM DMAHISGLVAA VV PFE+C +VTTTTHK+LRG R GMIF+
Sbjct: 204 DYARLRKIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFY 263
Query: 1105 KK-----DPVNGVE 1131
+K DP G E
Sbjct: 264 RKGVRSVDPKTGKE 277
>sp|O13426|GLYC_CANAL Serine hydroxymethyltransferase, cytosolic OS=Candida
albicans GN=SHM2 PE=1 SV=3
Length = 470
Score = 346 bits (887), Expect = 4e-094
Identities = 167/265 (63%), Positives = 204/265 (76%), Gaps = 5/265 (1%)
Frame = +1
Query: 379 EVDPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNE 558
+ DPEVD+IIK E +RQ S+ LIASENFT+ AV + +G+ + NKYSEG PG RYYGGNE
Sbjct: 20 DTDPEVDQIIKDEIDRQQHSIVLIASENFTTTAVFDALGTPMCNKYSEGYPGARYYGGNE 79
Query: 559 FIDQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGG 738
I ++ LCQ RAL F L KWGVNVQ LSGSPAN VY AI+KPH+R+MGLDLPHGG
Sbjct: 80 HIHRMELLCQERALKAFGLTPDKWGVNVQTLSGSPANLQVYQAIMKPHERLMGLDLPHGG 139
Query: 739 HLSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSR 918
HLSHG+ T R++S S YFE+MPYR+D TG++DYDMLEKTA L+RPK+++AG SAY R
Sbjct: 140 HLSHGYQTDSRKISAVSTYFETMPYRVDLETGLIDYDMLEKTAVLYRPKVLVAGTSAYCR 199
Query: 919 DFDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMI 1098
DY RMR+IAD VGA+L++DMAHISGL+AA V+ PFEY DIVTTTTHKSLRGPRG MI
Sbjct: 200 LIDYKRMREIADKVGAYLVVDMAHISGLIAAGVIPSPFEYADIVTTTTHKSLRGPRGAMI 259
Query: 1099 FFKK-----DPVNGVELESAINNAV 1158
FF++ +P G E+ + N +
Sbjct: 260 FFRRGVRSVNPKTGQEILYDLENPI 284
>sp|Q60V73|GLYC_CAEBR Serine hydroxymethyltransferase OS=Caenorhabditis briggsae
GN=mel-32 PE=3 SV=3
Length = 511
Score = 346 bits (885), Expect = 6e-094
Identities = 165/244 (67%), Positives = 196/244 (80%)
Frame = +1
Query: 379 EVDPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGNE 558
++DPEV I+K EK+RQ R LELIASENFTS+AVM+ +GS + NKYSEG PG RYYGGNE
Sbjct: 58 KIDPEVFNIMKNEKSRQRRGLELIASENFTSKAVMDALGSAMCNKYSEGYPGARYYGGNE 117
Query: 559 FIDQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHGG 738
FIDQ+ LCQ RAL F LD KWGVNVQ LSGSPANFAVYTA++ + RIMGLDLP GG
Sbjct: 118 FIDQMEILCQKRALEVFGLDPAKWGVNVQSLSGSPANFAVYTALVGANGRIMGLDLPDGG 177
Query: 739 HLSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYSR 918
HL+HGF T R+VS TS +F+SMPY++D +G++DYD LE+ A LFRPK++IAG S Y+R
Sbjct: 178 HLTHGFFTPARKVSATSEFFQSMPYKVDAQSGLIDYDKLEENAMLFRPKVLIAGVSCYAR 237
Query: 919 DFDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMI 1098
DY R RKIA GA+LM DMAHISGLVAA ++ PFEY D+VTTTTHKSLRGPRG MI
Sbjct: 238 HLDYERFRKIATKAGAYLMSDMAHISGLVAAGLIPSPFEYSDVVTTTTHKSLRGPRGAMI 297
Query: 1099 FFKK 1110
F++K
Sbjct: 298 FYRK 301
>sp|Q10104|GLYC_SCHPO Probable serine hydroxymethyltransferase, cytosolic
OS=Schizosaccharomyces pombe GN=shm2 PE=2 SV=1
Length = 472
Score = 345 bits (883), Expect = 1e-093
Identities = 164/245 (66%), Positives = 193/245 (78%)
Frame = +1
Query: 376 SEVDPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGN 555
+E DP V +I++ EK+RQ S+ LIASENFTSRAVM+ +GS + NKYSEG PG RYYGGN
Sbjct: 19 AECDPTVYKILESEKSRQKESIALIASENFTSRAVMDALGSIMQNKYSEGYPGARYYGGN 78
Query: 556 EFIDQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHG 735
EFIDQ LCQ RAL F LD KWGVNVQP SGSPAN Y A++KPHDR+MGLDLPHG
Sbjct: 79 EFIDQAERLCQTRALEAFHLDGEKWGVNVQPHSGSPANLQAYQAVMKPHDRLMGLDLPHG 138
Query: 736 GHLSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYS 915
GHLSHGF T ++ +S S YF +MPY +++ TGI+DYD LEK A FRPK+I+AGASAY+
Sbjct: 139 GHLSHGFSTPQKAISAVSTYFSTMPYNVNKETGIIDYDSLEKAAIQFRPKVIVAGASAYA 198
Query: 916 RDFDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGM 1095
R DY RMRKI + A+L+ DMAHISGLVAA V+ PFEY DIVTTTTHKSLRGPRG M
Sbjct: 199 RLVDYKRMRKITEMCNAYLLCDMAHISGLVAAGVIPSPFEYADIVTTTTHKSLRGPRGAM 258
Query: 1096 IFFKK 1110
IF++K
Sbjct: 259 IFYRK 263
>sp|P34897|GLYM_HUMAN Serine hydroxymethyltransferase, mitochondrial OS=Homo
sapiens GN=SHMT2 PE=1 SV=3
Length = 504
Score = 343 bits (878), Expect = 4e-093
Identities = 165/258 (63%), Positives = 204/258 (79%), Gaps = 5/258 (1%)
Frame = +1
Query: 376 SEVDPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGN 555
S+ DPE+ E++++EK+RQ R LELIASENF SRA +E +GSCL NKYSEG PGKRYYGG
Sbjct: 50 SDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGA 109
Query: 556 EFIDQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHG 735
E +D++ LCQ RAL F LD +WGVNVQP SGSPAN AVYTA+L+PHDRIMGLDLP G
Sbjct: 110 EVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDG 169
Query: 736 GHLSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYS 915
GHL+HG+M+ +R+S TSI+FESMPY+L+ TG++DY+ L TA LFRP+LIIAG SAY+
Sbjct: 170 GHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYA 229
Query: 916 RDFDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGM 1095
R DY RMR++ D V A L+ DMAHISGLVAA V+ PF++ DIVTTTTHK+LRG R G+
Sbjct: 230 RLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGL 289
Query: 1096 IFFKK-----DPVNGVEL 1134
IF++K DP G E+
Sbjct: 290 IFYRKGVKAVDPKTGREI 307
>sp|Q3SZ20|GLYM_BOVIN Serine hydroxymethyltransferase, mitochondrial OS=Bos
taurus GN=SHMT2 PE=2 SV=1
Length = 504
Score = 342 bits (877), Expect = 5e-093
Identities = 164/258 (63%), Positives = 203/258 (78%), Gaps = 5/258 (1%)
Frame = +1
Query: 376 SEVDPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGN 555
S+ DPE+ E++++EK+RQ R LELIASENF SRA +E +GSCL NKYSEG PGKRYYGG
Sbjct: 50 SDSDPEMWELLRREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGA 109
Query: 556 EFIDQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHG 735
E +D++ LCQ RAL F LD +WGVNVQP SGSPAN A YTA+L+PHDRIMGLDLP G
Sbjct: 110 EVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDG 169
Query: 736 GHLSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYS 915
GHL+HG+M+ +R+S TSI+FESMPY+L+ TG++DYD L TA LF+P+LIIAG SAY+
Sbjct: 170 GHLTHGYMSDVKRISATSIFFESMPYKLNPQTGLIDYDQLALTARLFKPRLIIAGTSAYA 229
Query: 916 RDFDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGM 1095
R DY RMR++ D V A L+ DMAHISGLVAA V+ PF++ DIVTTTTHK+LRG R G+
Sbjct: 230 RLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGL 289
Query: 1096 IFFKK-----DPVNGVEL 1134
IF++K DP G E+
Sbjct: 290 IFYRKGVQAVDPKTGREI 307
>sp|P14519|GLYM_RABIT Serine hydroxymethyltransferase, mitochondrial
OS=Oryctolagus cuniculus GN=SHMT2 PE=1 SV=2
Length = 504
Score = 341 bits (872), Expect = 2e-092
Identities = 163/258 (63%), Positives = 202/258 (78%), Gaps = 5/258 (1%)
Frame = +1
Query: 376 SEVDPEVDEIIKKEKNRQFRSLELIASENFTSRAVMETVGSCLTNKYSEGLPGKRYYGGN 555
S+ DPE+ E++++EK+RQ R LELIASENF RA +E +GSCL NKYSEG PGKRYYGG
Sbjct: 50 SDTDPEMWELLQREKDRQCRGLELIASENFCIRAALEALGSCLNNKYSEGYPGKRYYGGA 109
Query: 556 EFIDQL*TLCQNRALATFRLDSTKWGVNVQPLSGSPANFAVYTAILKPHDRIMGLDLPHG 735
E +D++ LCQ RAL F LD +WGVNVQP SGSPAN A YTA+L+PHDRIMGLDLP G
Sbjct: 110 EVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDG 169
Query: 736 GHLSHGFMTAKRRVSGTSIYFESMPYRLDESTGIVDYDMLEKTAALFRPKLIIAGASAYS 915
GHL+HG+M+ +RVS TSI+FESMPY+L+ TG++DY+ L TA LFRP+LIIAG SAY+
Sbjct: 170 GHLTHGYMSDVKRVSATSIFFESMPYKLNPQTGLIDYEQLALTARLFRPRLIIAGTSAYA 229
Query: 916 RDFDYPRMRKIADSVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGM 1095
R DY RMR++ D V A L+ DMAHISGLVAA V+ PF++ D+VTTTTHK+LRG R G+
Sbjct: 230 RLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADVVTTTTHKTLRGARSGL 289
Query: 1096 IFFKK-----DPVNGVEL 1134
IF++K DP G E+
Sbjct: 290 IFYRKGVRTVDPKTGQEI 307
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,891,173,716
Number of Sequences: 518415
Number of Extensions: 89891173716
Number of Successful Extensions: 595657870
Number of sequences better than 0.0: 0
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