BLASTX 7.6.2
Query= UN21783 /QuerySize=1110
(1109 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P40961|PHB1_YEAST Prohibitin-1 OS=Saccharomyces cerevisiae GN... 309 4e-083
sp|Q54GI9|PHB1_DICDI Prohibitin-1, mitochondrial OS=Dictyosteliu... 307 1e-082
sp|P84173|PHB_CHICK Prohibitin OS=Gallus gallus GN=PHB PE=1 SV=1 305 3e-082
sp|Q3T165|PHB_BOVIN Prohibitin OS=Bos taurus GN=PHB PE=2 SV=1 300 2e-080
sp|P35232|PHB_HUMAN Prohibitin OS=Homo sapiens GN=PHB PE=1 SV=1 300 2e-080
sp|P67778|PHB_MOUSE Prohibitin OS=Mus musculus GN=Phb PE=1 SV=1 299 4e-080
sp|P67779|PHB_RAT Prohibitin OS=Rattus norvegicus GN=Phb PE=1 SV=1 299 4e-080
sp|Q9P7H3|PHB1_SCHPO Prohibitin-1 OS=Schizosaccharomyces pombe G... 297 9e-080
sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex protein 1 ... 294 1e-078
sp|P24156|L2CC_DROME Protein l(2)37Cc OS=Drosophila melanogaster... 290 1e-077
sp|Q54Q31|PHB2_DICDI Prohibitin-2 OS=Dictyostelium discoideum GN... 280 2e-074
sp|P50085|PHB2_YEAST Prohibitin-2 OS=Saccharomyces cerevisiae GN... 273 2e-072
sp|A9UMS3|PHB2_XENTR Prohibitin-2 OS=Xenopus tropicalis GN=phb2 ... 264 9e-070
sp|Q2HJ97|PHB2_BOVIN Prohibitin-2 OS=Bos taurus GN=PHB2 PE=2 SV=1 262 4e-069
sp|Q99623|PHB2_HUMAN Prohibitin-2 OS=Homo sapiens GN=PHB2 PE=1 SV=2 260 1e-068
sp|O35129|PHB2_MOUSE Prohibitin-2 OS=Mus musculus GN=Phb2 PE=1 SV=1 260 1e-068
sp|Q5XIH7|PHB2_RAT Prohibitin-2 OS=Rattus norvegicus GN=Phb2 PE=... 260 1e-068
sp|Q5RB19|PHB2_PONAB Prohibitin-2 OS=Pongo abelii GN=PHB2 PE=2 SV=1 259 3e-068
sp|O94550|PHB2_SCHPO Prohibitin-2 OS=Schizosaccharomyces pombe G... 257 1e-067
sp|Q5ZMN3|PHB2_CHICK Prohibitin-2 OS=Gallus gallus GN=PHB2 PE=2 ... 253 2e-066
>sp|P40961|PHB1_YEAST Prohibitin-1 OS=Saccharomyces cerevisiae GN=PHB1 PE=1
SV=2
Length = 287
Score = 309 bits (789), Expect = 4e-083
Identities = 154/257 (59%), Positives = 204/257 (79%)
Frame = +1
Query: 94 LAKAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTVGEGTHFLIPILQKPHIFD 273
+ K A +G A+ + S+Y V GG R VIFDR GV Q VGEGTHFL+P LQK I+D
Sbjct: 11 ITKVALPIGIIASGIQYSMYDVKGGSRGVIFDRINGVKQQVVGEGTHFLVPWLQKAIIYD 70
Query: 274 IRTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPSIGNEVLK 453
+RTKP + ++ +GTKDLQMV+LTLRVL RPEV++LP I+Q LGL+YDE+VLPSIGNEVLK
Sbjct: 71 VRTKPKSIATNTGTKDLQMVSLTLRVLHRPEVLQLPAIYQNLGLDYDERVLPSIGNEVLK 130
Query: 454 AVVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSKAVEQKQV 633
++VAQF+A +L+T+R +S +R+ L RA +F I L+DV+ITH+++G EF+KAVEQKQ+
Sbjct: 131 SIVAQFDAAELITQREIISQKIRKELSTRANEFGIKLEDVSITHMTFGPEFTKAVEQKQI 190
Query: 634 AQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVA 813
AQQ+AER+KF+V KA+QER+A+VIRAEGE+E+A+ IS A AK G GL+ +RR+EAS+++A
Sbjct: 191 AQQDAERAKFLVEKAEQERQASVIRAEGEAESAEFISKALAKVGDGLLLIRRLEASKDIA 250
Query: 814 ATLARSPNVAYLPGGQS 864
TLA S NV YLP S
Sbjct: 251 QTLANSSNVVYLPSQHS 267
>sp|Q54GI9|PHB1_DICDI Prohibitin-1, mitochondrial OS=Dictyostelium discoideum
GN=phbA PE=3 SV=1
Length = 271
Score = 307 bits (785), Expect = 1e-082
Identities = 152/269 (56%), Positives = 211/269 (78%), Gaps = 1/269 (0%)
Frame = +1
Query: 79 SFLSNLAKAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTVGEGTHFLIPILQK 258
SFL+ L A +GT ++ +S+YTVDGG+RAVIFDR GV +++VGEGTHF++P LQK
Sbjct: 3 SFLNKLIPLALTVGTGLSLAQSSMYTVDGGQRAVIFDRISGVKEKSVGEGTHFIMPWLQK 62
Query: 259 PHIFDIRTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPSIG 438
P IFDIR+ P S +G+KDLQ V++T+RVL RP+V LP IF LGL+YDE++LPS+G
Sbjct: 63 PIIFDIRSSPRNIKSDTGSKDLQTVSVTVRVLFRPDVEHLPSIFSKLGLDYDERILPSLG 122
Query: 439 NEVLKAVVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSKAV 618
NEVLK+VVAQ++A +L+T+R VS +RESL+KRAK+FN++LDDV+ITHLS+ +F+ A+
Sbjct: 123 NEVLKSVVAQYDATELITQREVVSKEIRESLMKRAKEFNLLLDDVSITHLSFSQDFTNAI 182
Query: 619 EQKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEA 798
E KQVAQQEAERSK++VMK +QE++A +IRAEGE+EAA+LI A + IELRRIEA
Sbjct: 183 EHKQVAQQEAERSKYIVMKNEQEKKANIIRAEGEAEAAKLIGQAMGNSA-AFIELRRIEA 241
Query: 799 SREVAATLARSPNVAYLPGGQSMLFSLNR 885
+++ +L++S V Y+P ++L +LN+
Sbjct: 242 YKDITESLSKSKQVTYVPTSGNLLMNLNK 270
>sp|P84173|PHB_CHICK Prohibitin OS=Gallus gallus GN=PHB PE=1 SV=1
Length = 272
Score = 305 bits (781), Expect = 3e-082
Identities = 152/269 (56%), Positives = 206/269 (76%)
Frame = +1
Query: 73 AVSFLSNLAKAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTVGEGTHFLIPIL 252
A ++ K GL A V+N++LY VD G RAVIFDRFRGV D VGEGTHFLIP +
Sbjct: 2 AAKVFESIGKFGLGLAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDTVVGEGTHFLIPWV 61
Query: 253 QKPHIFDIRTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPS 432
QKP IFD R++P I+G+KDLQ VN+TLR+L RP +LP IF ++G +YDE+VLPS
Sbjct: 62 QKPIIFDCRSRPRNIPVITGSKDLQNVNITLRILFRPVTAQLPRIFTSIGEDYDERVLPS 121
Query: 433 IGNEVLKAVVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSK 612
I E+LK+VVA+F+A +L+T+R VS V E L +RA F ++LDDV++THL++G EF++
Sbjct: 122 ITTEILKSVVARFDAGELITQRELVSRQVSEDLTERAATFGLILDDVSLTHLTFGKEFTE 181
Query: 613 AVEQKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRI 792
AVE KQVAQQEAER++F+V KA+Q+++AAVI AEG+S+AA+LI+++ A AG GLIELR++
Sbjct: 182 AVEMKQVAQQEAERARFIVEKAEQQKKAAVISAEGDSKAAELIANSLATAGDGLIELRKL 241
Query: 793 EASREVAATLARSPNVAYLPGGQSMLFSL 879
EA+ ++A L+RS N+ YLP GQS+L L
Sbjct: 242 EAAEDIAYQLSRSRNITYLPSGQSVLLQL 270
>sp|Q3T165|PHB_BOVIN Prohibitin OS=Bos taurus GN=PHB PE=2 SV=1
Length = 272
Score = 300 bits (766), Expect = 2e-080
Identities = 150/269 (55%), Positives = 205/269 (76%)
Frame = +1
Query: 73 AVSFLSNLAKAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTVGEGTHFLIPIL 252
A ++ K L A V+N++LY VD G RAVIFDRFRGV D VGEGTHFLIP +
Sbjct: 2 AAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWV 61
Query: 253 QKPHIFDIRTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPS 432
QKP IFD R++P I+G+KDLQ VN+TLR+L RP +LP IF ++G +YDE+VLPS
Sbjct: 62 QKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPS 121
Query: 433 IGNEVLKAVVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSK 612
I E+LK+VVA+F+A +L+T+R VS V + L +RA F ++LDDV++THL++G EF++
Sbjct: 122 ITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTE 181
Query: 613 AVEQKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRI 792
AVE KQVAQQEAER++FVV KA+Q+++AA+I AEG+S+AA+LI+++ A AG GLIELR++
Sbjct: 182 AVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKL 241
Query: 793 EASREVAATLARSPNVAYLPGGQSMLFSL 879
EA+ ++A L+RS N+ YLP GQS+L L
Sbjct: 242 EAAEDIAYQLSRSRNITYLPAGQSVLLQL 270
>sp|P35232|PHB_HUMAN Prohibitin OS=Homo sapiens GN=PHB PE=1 SV=1
Length = 272
Score = 300 bits (766), Expect = 2e-080
Identities = 150/269 (55%), Positives = 205/269 (76%)
Frame = +1
Query: 73 AVSFLSNLAKAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTVGEGTHFLIPIL 252
A ++ K L A V+N++LY VD G RAVIFDRFRGV D VGEGTHFLIP +
Sbjct: 2 AAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWV 61
Query: 253 QKPHIFDIRTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPS 432
QKP IFD R++P I+G+KDLQ VN+TLR+L RP +LP IF ++G +YDE+VLPS
Sbjct: 62 QKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPS 121
Query: 433 IGNEVLKAVVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSK 612
I E+LK+VVA+F+A +L+T+R VS V + L +RA F ++LDDV++THL++G EF++
Sbjct: 122 ITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTE 181
Query: 613 AVEQKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRI 792
AVE KQVAQQEAER++FVV KA+Q+++AA+I AEG+S+AA+LI+++ A AG GLIELR++
Sbjct: 182 AVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKL 241
Query: 793 EASREVAATLARSPNVAYLPGGQSMLFSL 879
EA+ ++A L+RS N+ YLP GQS+L L
Sbjct: 242 EAAEDIAYQLSRSRNITYLPAGQSVLLQL 270
>sp|P67778|PHB_MOUSE Prohibitin OS=Mus musculus GN=Phb PE=1 SV=1
Length = 272
Score = 299 bits (763), Expect = 4e-080
Identities = 149/269 (55%), Positives = 205/269 (76%)
Frame = +1
Query: 73 AVSFLSNLAKAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTVGEGTHFLIPIL 252
A ++ K L A V+N++LY VD G RAVIFDRFRGV D VGEGTHFLIP +
Sbjct: 2 AAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWV 61
Query: 253 QKPHIFDIRTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPS 432
QKP IFD R++P I+G+KDLQ VN+TLR+L RP +LP I+ ++G +YDE+VLPS
Sbjct: 62 QKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLPS 121
Query: 433 IGNEVLKAVVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSK 612
I E+LK+VVA+F+A +L+T+R VS V + L +RA F ++LDDV++THL++G EF++
Sbjct: 122 ITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTE 181
Query: 613 AVEQKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRI 792
AVE KQVAQQEAER++FVV KA+Q+++AA+I AEG+S+AA+LI+++ A AG GLIELR++
Sbjct: 182 AVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKL 241
Query: 793 EASREVAATLARSPNVAYLPGGQSMLFSL 879
EA+ ++A L+RS N+ YLP GQS+L L
Sbjct: 242 EAAEDIAYQLSRSRNITYLPAGQSVLLQL 270
>sp|P67779|PHB_RAT Prohibitin OS=Rattus norvegicus GN=Phb PE=1 SV=1
Length = 272
Score = 299 bits (763), Expect = 4e-080
Identities = 149/269 (55%), Positives = 205/269 (76%)
Frame = +1
Query: 73 AVSFLSNLAKAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTVGEGTHFLIPIL 252
A ++ K L A V+N++LY VD G RAVIFDRFRGV D VGEGTHFLIP +
Sbjct: 2 AAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWV 61
Query: 253 QKPHIFDIRTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPS 432
QKP IFD R++P I+G+KDLQ VN+TLR+L RP +LP I+ ++G +YDE+VLPS
Sbjct: 62 QKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLPS 121
Query: 433 IGNEVLKAVVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSK 612
I E+LK+VVA+F+A +L+T+R VS V + L +RA F ++LDDV++THL++G EF++
Sbjct: 122 ITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTE 181
Query: 613 AVEQKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRI 792
AVE KQVAQQEAER++FVV KA+Q+++AA+I AEG+S+AA+LI+++ A AG GLIELR++
Sbjct: 182 AVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKL 241
Query: 793 EASREVAATLARSPNVAYLPGGQSMLFSL 879
EA+ ++A L+RS N+ YLP GQS+L L
Sbjct: 242 EAAEDIAYQLSRSRNITYLPAGQSVLLQL 270
>sp|Q9P7H3|PHB1_SCHPO Prohibitin-1 OS=Schizosaccharomyces pombe GN=phb1 PE=2
SV=1
Length = 282
Score = 297 bits (760), Expect = 9e-080
Identities = 150/259 (57%), Positives = 204/259 (78%), Gaps = 1/259 (0%)
Frame = +1
Query: 85 LSNLAKAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTVGEGTHFLIPILQKPH 264
L +A+ A +G T+L +S+Y V GG+RAV+FDR GV Q V EGTHFLIP LQK
Sbjct: 5 LERVARYAIPIGIGFTLLQSSIYDVPGGKRAVLFDRLSGVQKQVVQEGTHFLIPWLQKAI 64
Query: 265 IFDIRTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPSIGNE 444
++D+RT+P ++ +G+KDLQMV+LTLRVL RPEV LP I+Q LGL+YDE+VLPSIGNE
Sbjct: 65 VYDVRTRPRNIATTTGSKDLQMVSLTLRVLHRPEVGMLPQIYQNLGLDYDERVLPSIGNE 124
Query: 445 VLKAVVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSKAVEQ 624
+LK+VVAQF+A +L+T+R VSA +R+ L++RA +F I L+DV+ITH+++G EF+KAVE+
Sbjct: 125 ILKSVVAQFDAAELITQREVVSAKIRQELVQRATEFGIRLEDVSITHMTFGKEFTKAVER 184
Query: 625 KQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASR 804
KQ+AQQEAER++F+V +++QER+A VIRAEGE+EAA ++S A KAG LI++RR+E S+
Sbjct: 185 KQIAQQEAERARFLVEQSEQERQANVIRAEGEAEAADIVSKALDKAGGALIQIRRLETSK 244
Query: 805 EVAATLA-RSPNVAYLPGG 858
EVA LA + V YLP G
Sbjct: 245 EVATALANKGAQVTYLPFG 263
>sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex protein 1
OS=Caenorhabditis elegans GN=phb-1 PE=1 SV=1
Length = 275
Score = 294 bits (750), Expect = 1e-078
Identities = 149/270 (55%), Positives = 202/270 (74%)
Frame = +1
Query: 70 AAVSFLSNLAKAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTVGEGTHFLIPI 249
+A L L GL A + T+LY VDGG+RAVIFDRF GV ++ VGEGTHFLIP
Sbjct: 4 SAQKLLGRLGTVGVGLSIAGGIAQTALYNVDGGQRAVIFDRFSGVKNEVVGEGTHFLIPW 63
Query: 250 LQKPHIFDIRTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLP 429
+QKP IFDIR+ P ++I+G+KDLQ VN+TLR+L RP RLP I+ +GL+Y E+VLP
Sbjct: 64 VQKPIIFDIRSTPRAVTTITGSKDLQNVNITLRILHRPSPDRLPNIYLNIGLDYAERVLP 123
Query: 430 SIGNEVLKAVVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFS 609
SI NEVLKAVVAQF+A +++T+R VS +L +RA F ++LDD+AITHL++G EF+
Sbjct: 124 SITNEVLKAVVAQFDAHEMITQREVVSQRASVALRERAAQFGLLLDDIAITHLNFGREFT 183
Query: 610 KAVEQKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRR 789
+AVE KQVAQQEAE+++++V KA+Q + AAV AEG+++AA+L++ A A AG GL+ELR+
Sbjct: 184 EAVEMKQVAQQEAEKARYLVEKAEQMKIAAVTTAEGDAQAAKLLAKAFASAGDGLVELRK 243
Query: 790 IEASREVAATLARSPNVAYLPGGQSMLFSL 879
IEA+ E+A +A++ NV YLPG Q L +L
Sbjct: 244 IEAAEEIAERMAKNKNVTYLPGNQQTLLNL 273
>sp|P24156|L2CC_DROME Protein l(2)37Cc OS=Drosophila melanogaster GN=l(2)37Cc
PE=1 SV=2
Length = 276
Score = 290 bits (742), Expect = 1e-077
Identities = 146/269 (54%), Positives = 200/269 (74%)
Frame = +1
Query: 73 AVSFLSNLAKAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTVGEGTHFLIPIL 252
A F + + + G+ V+N++LY V+GG RAVIFDRF G+ + VGEGTHF IP +
Sbjct: 2 AAQFFNRIGQMGLGVAVLGGVVNSALYNVEGGHRAVIFDRFTGIKENVVGEGTHFFIPWV 61
Query: 253 QKPHIFDIRTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPS 432
Q+P IFDIR++P I+G+KDLQ VN+TLR+L RP +LP I+ LG +YDE+VLPS
Sbjct: 62 QRPIIFDIRSQPRNVPVITGSKDLQNVNITLRILYRPIPDQLPKIYTILGQDYDERVLPS 121
Query: 433 IGNEVLKAVVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSK 612
I EVLKAVVAQF+A +L+T+R VS V + L RAK F +LDD+++THL++G EF+
Sbjct: 122 IAPEVLKAVVAQFDAGELITQREMVSQRVSQELTVRAKQFGFILDDISLTHLTFGREFTL 181
Query: 613 AVEQKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRI 792
AVE KQVAQQEAE+++FVV KA+Q++ A++I AEG++EAA L++ + +AG GL+ELRRI
Sbjct: 182 AVEMKQVAQQEAEKARFVVEKAEQQKLASIISAEGDAEAAGLLAKSFGEAGDGLVELRRI 241
Query: 793 EASREVAATLARSPNVAYLPGGQSMLFSL 879
EA+ ++A L+RS VAYLP GQS L +L
Sbjct: 242 EAAEDIAYQLSRSRGVAYLPSGQSTLLNL 270
>sp|Q54Q31|PHB2_DICDI Prohibitin-2 OS=Dictyostelium discoideum GN=phbB PE=3
SV=1
Length = 293
Score = 280 bits (714), Expect = 2e-074
Identities = 143/287 (49%), Positives = 213/287 (74%), Gaps = 12/287 (4%)
Frame = +1
Query: 55 MGSQQAAVSF--LSNLAKAAFG-------LGTAATVLNTSLYTVDGGERAVIFDRFRGVM 207
M +++ V+F + L K +FG LG + +SL V+GG RA++F+RF G+
Sbjct: 1 MNNKKFQVNFNNIPKLPKGSFGGGFGLLALGGVGLLALSSLVNVEGGHRAIVFNRFVGIK 60
Query: 208 DQTVGEGTHFLIPILQKPHIFDIRTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYI 387
++ EGTHF++P ++ I+D+R KP + SS++G+KDLQMVN+T+RVLS+P+V +LP I
Sbjct: 61 NKVYNEGTHFIVPWFERAEIYDVRAKPRSISSLTGSKDLQMVNITIRVLSKPKVSQLPAI 120
Query: 388 FQTLGLEYDEKVLPSIGNEVLKAVVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLD 567
++TLG +YDE+VLPSI NE+LK++VAQFNA QL+T+R VS L+ + L+ RAKDFNI LD
Sbjct: 121 YRTLGKDYDERVLPSIVNEILKSIVAQFNASQLITQREQVSRLIFKRLVDRAKDFNIELD 180
Query: 568 DVAITHLSYGYEFSKAVEQKQVAQQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISD 747
DV+ITHL++G E++ A+E KQVAQQEAER++F+V KA Q++R+ +++AEGE+++AQLI+D
Sbjct: 181 DVSITHLNFGREYAAAIEAKQVAQQEAERARFLVEKALQDKRSIIVKAEGEAQSAQLIND 240
Query: 748 ATAKAGMGLIELRRIEASREVAATLARSPNVAYLPGGQSML--FSLN 882
A K L++LR +EAS+E+A L++SPN Y+ +L F LN
Sbjct: 241 A-IKQSPYLVQLRTLEASKEIAHILSKSPNKLYISNETLLLNGFDLN 286
>sp|P50085|PHB2_YEAST Prohibitin-2 OS=Saccharomyces cerevisiae GN=PHB2 PE=1
SV=2
Length = 310
Score = 273 bits (697), Expect = 2e-072
Identities = 133/241 (55%), Positives = 187/241 (77%), Gaps = 1/241 (0%)
Frame = +1
Query: 115 LGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTVGEGTHFLIPILQKPHIFDIRTKPHT 294
LG A +N +L+ VDGG RA+++ R GV + EGTHF+ P L P I+D+R KP
Sbjct: 47 LGGGALFINNALFNVDGGHRAIVYSRIHGVSSRIFNEGTHFIFPWLDTPIIYDVRAKPRN 106
Query: 295 FSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPSIGNEVLKAVVAQFN 474
+S++GTKDLQMVN+T RVLSRP+VV+LP I++TLG +YDE+VLPSI NEVLKAVVAQFN
Sbjct: 107 VASLTGTKDLQMVNITCRVLSRPDVVQLPTIYRTLGQDYDERVLPSIVNEVLKAVVAQFN 166
Query: 475 ADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSKAVEQKQVAQQEAER 654
A QL+T+R VS L+RE+L++RA FNI+LDDV+IT++++ EF+ AVE KQ+AQQ+A+R
Sbjct: 167 ASQLITQREKVSRLIRENLVRRASKFNILLDDVSITYMTFSPEFTNAVEAKQIAQQDAQR 226
Query: 655 SKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAATLARSP 834
+ FVV KA QE++ V+RA+GE+++A+LI +A K+ +EL+R++ +R++A LA SP
Sbjct: 227 AAFVVDKARQEKQGMVVRAQGEAKSAELIGEAIKKS-RDYVELKRLDTARDIAKILASSP 285
Query: 835 N 837
N
Sbjct: 286 N 286
>sp|A9UMS3|PHB2_XENTR Prohibitin-2 OS=Xenopus tropicalis GN=phb2 PE=2 SV=1
Length = 301
Score = 264 bits (674), Expect = 9e-070
Identities = 136/251 (54%), Positives = 184/251 (73%), Gaps = 2/251 (0%)
Frame = +1
Query: 100 KAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTV-GEGTHFLIPILQKPHIFDI 276
K G G A + S++TV+GG RA+ F+R GV T+ EG HF P Q P I+DI
Sbjct: 24 KLLLGAGAVAYAVKESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRFPWFQYPIIYDI 83
Query: 277 RTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPSIGNEVLKA 456
R +P SS +G+KDLQMVN+TLRVLSRP LP+++Q LGL+YDE+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNITLRVLSRPLASELPFMYQRLGLDYDERVLPSIVNEVLKS 143
Query: 457 VVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSKAVEQKQVA 636
VVA+FNA QL+T+R VS L+R L +RAKDF+I+LDDVAIT LS+ E++ AVE KQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSIILDDVAITELSFSREYTAAVESKQVA 203
Query: 637 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 816
QQEA+R++F+V KA Q+++ +++AEGE+ AA++I DA +K G ++LRRI A++ +A
Sbjct: 204 QQEAQRAQFLVEKAKQDQKQKIVQAEGEAAAAKMIGDALSK-NPGYLKLRRIRAAQSIAK 262
Query: 817 TLARSPNVAYL 849
T+A S N YL
Sbjct: 263 TIASSQNRVYL 273
>sp|Q2HJ97|PHB2_BOVIN Prohibitin-2 OS=Bos taurus GN=PHB2 PE=2 SV=1
Length = 299
Score = 262 bits (668), Expect = 4e-069
Identities = 135/258 (52%), Positives = 188/258 (72%), Gaps = 2/258 (0%)
Frame = +1
Query: 100 KAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTV-GEGTHFLIPILQKPHIFDI 276
K G G A + S++TV+GG RA+ F+R GV T+ EG HF IP Q P I+DI
Sbjct: 24 KLLLGAGAVAYGIRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83
Query: 277 RTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPSIGNEVLKA 456
R +P SS +G+KDLQMVN++LRVLSRP + LP ++Q LGL+Y+E+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNISLRVLSRPNAMELPSMYQRLGLDYEERVLPSIVNEVLKS 143
Query: 457 VVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSKAVEQKQVA 636
VVA+FNA QL+T+R VS L+R L +RAKDF+++LDDVAIT LS+ E++ AVE KQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVA 203
Query: 637 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 816
QQEA+R++F+V KA QE+R +++AEGE+EAA+++ +A +K G I+LR+I A++ ++
Sbjct: 204 QQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAARMLGEALSK-NPGYIKLRKIRAAQNISK 262
Query: 817 TLARSPNVAYLPGGQSML 870
T+A S N YL +L
Sbjct: 263 TIATSQNRIYLTADNLVL 280
>sp|Q99623|PHB2_HUMAN Prohibitin-2 OS=Homo sapiens GN=PHB2 PE=1 SV=2
Length = 299
Score = 260 bits (664), Expect = 1e-068
Identities = 135/258 (52%), Positives = 187/258 (72%), Gaps = 2/258 (0%)
Frame = +1
Query: 100 KAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTV-GEGTHFLIPILQKPHIFDI 276
K G G A + S++TV+GG RA+ F+R GV T+ EG HF IP Q P I+DI
Sbjct: 24 KLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83
Query: 277 RTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPSIGNEVLKA 456
R +P SS +G+KDLQMVN++LRVLSRP LP ++Q LGL+Y+E+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKS 143
Query: 457 VVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSKAVEQKQVA 636
VVA+FNA QL+T+R VS L+R L +RAKDF+++LDDVAIT LS+ E++ AVE KQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVA 203
Query: 637 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 816
QQEA+R++F+V KA QE+R +++AEGE+EAA+++ +A +K G I+LR+I A++ ++
Sbjct: 204 QQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISK 262
Query: 817 TLARSPNVAYLPGGQSML 870
T+A S N YL +L
Sbjct: 263 TIATSQNRIYLTADNLVL 280
>sp|O35129|PHB2_MOUSE Prohibitin-2 OS=Mus musculus GN=Phb2 PE=1 SV=1
Length = 299
Score = 260 bits (664), Expect = 1e-068
Identities = 135/258 (52%), Positives = 187/258 (72%), Gaps = 2/258 (0%)
Frame = +1
Query: 100 KAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTV-GEGTHFLIPILQKPHIFDI 276
K G G A + S++TV+GG RA+ F+R GV T+ EG HF IP Q P I+DI
Sbjct: 24 KLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83
Query: 277 RTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPSIGNEVLKA 456
R +P SS +G+KDLQMVN++LRVLSRP LP ++Q LGL+Y+E+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKS 143
Query: 457 VVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSKAVEQKQVA 636
VVA+FNA QL+T+R VS L+R L +RAKDF+++LDDVAIT LS+ E++ AVE KQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVA 203
Query: 637 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 816
QQEA+R++F+V KA QE+R +++AEGE+EAA+++ +A +K G I+LR+I A++ ++
Sbjct: 204 QQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISK 262
Query: 817 TLARSPNVAYLPGGQSML 870
T+A S N YL +L
Sbjct: 263 TIATSQNRIYLTADNLVL 280
>sp|Q5XIH7|PHB2_RAT Prohibitin-2 OS=Rattus norvegicus GN=Phb2 PE=1 SV=1
Length = 299
Score = 260 bits (664), Expect = 1e-068
Identities = 135/258 (52%), Positives = 187/258 (72%), Gaps = 2/258 (0%)
Frame = +1
Query: 100 KAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTV-GEGTHFLIPILQKPHIFDI 276
K G G A + S++TV+GG RA+ F+R GV T+ EG HF IP Q P I+DI
Sbjct: 24 KLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83
Query: 277 RTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPSIGNEVLKA 456
R +P SS +G+KDLQMVN++LRVLSRP LP ++Q LGL+Y+E+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKS 143
Query: 457 VVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSKAVEQKQVA 636
VVA+FNA QL+T+R VS L+R L +RAKDF+++LDDVAIT LS+ E++ AVE KQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVA 203
Query: 637 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 816
QQEA+R++F+V KA QE+R +++AEGE+EAA+++ +A +K G I+LR+I A++ ++
Sbjct: 204 QQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISK 262
Query: 817 TLARSPNVAYLPGGQSML 870
T+A S N YL +L
Sbjct: 263 TIATSQNRIYLTADNLVL 280
>sp|Q5RB19|PHB2_PONAB Prohibitin-2 OS=Pongo abelii GN=PHB2 PE=2 SV=1
Length = 299
Score = 259 bits (661), Expect = 3e-068
Identities = 135/261 (51%), Positives = 190/261 (72%), Gaps = 3/261 (1%)
Frame = +1
Query: 100 KAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTV-GEGTHFLIPILQKPHIFDI 276
K G G A + S++TV+GG RA+ F+R GV T+ EG HF IP Q P I+DI
Sbjct: 24 KLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83
Query: 277 RTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPSIGNEVLKA 456
R +P SS +G+KDLQMVN++LRVLSRP LP ++Q LGL+Y+E+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKS 143
Query: 457 VVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSKAVEQKQVA 636
VVA+FNA QL+T+R VS L+R L +RAKDF+++LDDVAIT LS+ E++ AVE KQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVA 203
Query: 637 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 816
QQEA+R++F+V KA QE+R +++AEGE+EAA+++ +A +K G I+LR+I A++ ++
Sbjct: 204 QQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSK-NPGYIKLRKIRAAQNISK 262
Query: 817 TLARSPNVAYLPGGQSMLFSL 879
T+A S N Y P +++ +L
Sbjct: 263 TIATSQNRIY-PTADNLVLNL 282
>sp|O94550|PHB2_SCHPO Prohibitin-2 OS=Schizosaccharomyces pombe GN=phb2 PE=2
SV=1
Length = 279
Score = 257 bits (655), Expect = 1e-067
Identities = 134/252 (53%), Positives = 181/252 (71%), Gaps = 1/252 (0%)
Frame = +1
Query: 115 LGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTVGEGTHFLIPILQKPHIFDIRTKPHT 294
LG A + TSL+ VDGG RA+ + R G+ + EGTHFLIP ++ +D+R KP
Sbjct: 25 LGLAGFAVQTSLFNVDGGHRAIKYSRIGGIKNLIYPEGTHFLIPWIETAIDYDVRAKPRN 84
Query: 295 FSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPSIGNEVLKAVVAQFN 474
SS++GTKDLQMVN+ RVLSRP+V LP I++TLG +YDE+VLPSI NEVLK+VVAQFN
Sbjct: 85 ISSLTGTKDLQMVNINCRVLSRPDVHALPKIYRTLGGDYDERVLPSIVNEVLKSVVAQFN 144
Query: 475 ADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSKAVEQKQVAQQEAER 654
A QL+T+R VS LVRE+L+KRA FNI+LDDV++TH+ + EF+ AVE KQ+AQQ+A+R
Sbjct: 145 ASQLITQRERVSRLVRENLMKRAARFNILLDDVSLTHVQFSPEFTAAVEAKQIAQQDAQR 204
Query: 655 SKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAATLARSP 834
+ F V +A E++ ++RA+GE AAQLI +A K G IELR++E +RE+A L++S
Sbjct: 205 ATFYVDRARMEKQGFIVRAQGEGRAAQLIGEA-IKNKPGFIELRKLETAREIANILSKSN 263
Query: 835 NVAYLPGGQSML 870
N L +L
Sbjct: 264 NKVMLNASTLLL 275
>sp|Q5ZMN3|PHB2_CHICK Prohibitin-2 OS=Gallus gallus GN=PHB2 PE=2 SV=1
Length = 301
Score = 253 bits (646), Expect = 2e-066
Identities = 130/258 (50%), Positives = 186/258 (72%), Gaps = 2/258 (0%)
Frame = +1
Query: 100 KAAFGLGTAATVLNTSLYTVDGGERAVIFDRFRGVMDQTV-GEGTHFLIPILQKPHIFDI 276
K G G A + S++ V+GG+RA+ F+R GV T+ EG HF IP Q P I+DI
Sbjct: 24 KLLLGAGALAYGVRESVFIVEGGQRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDI 83
Query: 277 RTKPHTFSSISGTKDLQMVNLTLRVLSRPEVVRLPYIFQTLGLEYDEKVLPSIGNEVLKA 456
R +P SS +G+KDLQMVN++LRVL+RP LP ++Q LGL+Y+E+VLPSI NEVLK+
Sbjct: 84 RARPRKISSPTGSKDLQMVNISLRVLTRPNAAELPSMYQRLGLDYEERVLPSIVNEVLKS 143
Query: 457 VVAQFNADQLLTERPHVSALVRESLIKRAKDFNIVLDDVAITHLSYGYEFSKAVEQKQVA 636
VVA+FNA QL+T+R VS L+R L +RAKDF+++LDDVAIT LS+ E++ AVE KQVA
Sbjct: 144 VVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVA 203
Query: 637 QQEAERSKFVVMKADQERRAAVIRAEGESEAAQLISDATAKAGMGLIELRRIEASREVAA 816
QQEA+R++F+V KA QE++ +++AEGE+ AA+++ +A ++ G I+LR+I A++ ++
Sbjct: 204 QQEAQRAQFLVEKAKQEQKQKIVQAEGEATAAKMLGEALSR-NPGYIKLRKIRAAQNISK 262
Query: 817 TLARSPNVAYLPGGQSML 870
T+A S N YL +L
Sbjct: 263 TIAGSQNRVYLTADNLVL 280
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,891,173,716
Number of Sequences: 518415
Number of Extensions: 89891173716
Number of Successful Extensions: 595657870
Number of sequences better than 0.0: 0
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