BLASTX 7.6.2
Query= UN22164 /QuerySize=1244
(1243 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus ... 200 3e-050
sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo... 193 4e-048
sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pong... 191 8e-048
sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gall... 190 2e-047
sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Dani... 190 2e-047
sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 OS=Homo sapiens G... 180 2e-044
sp|Q8VBZ0|DHRSX_MOUSE Dehydrogenase/reductase SDR family member ... 175 6e-043
sp|Q9VLU5|WWOX_DROME WW domain-containing oxidoreductase OS=Dros... 175 6e-043
sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member ... 173 2e-042
sp|Q8CEE7|RDH13_MOUSE Retinol dehydrogenase 13 OS=Mus musculus G... 170 2e-041
sp|O74959|YJCD_SCHPO Uncharacterized oxidoreductase C736.13 OS=S... 159 6e-038
sp|Q5SS80|DHR13_MOUSE Dehydrogenase/reductase SDR family member ... 151 1e-035
sp|Q03326|OXIR_STRAT Probable oxidoreductase OS=Streptomyces ant... 137 2e-031
sp|Q17QU7|DHR13_BOVIN Dehydrogenase/reductase SDR family member ... 125 7e-028
sp|Q9QYF1|RDH11_MOUSE Retinol dehydrogenase 11 OS=Mus musculus G... 121 1e-026
sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 OS=Mus musculus G... 119 7e-026
sp|Q8TC12|RDH11_HUMAN Retinol dehydrogenase 11 OS=Homo sapiens G... 118 9e-026
sp|Q6UX07|DHR13_HUMAN Dehydrogenase/reductase SDR family member ... 118 1e-025
sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 OS=Bos taurus GN=... 117 2e-025
sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 OS=Homo sapiens G... 114 2e-024
>sp|Q91WL8|WWOX_MOUSE WW domain-containing oxidoreductase OS=Mus musculus
GN=Wwox PE=1 SV=1
Length = 414
Score = 200 bits (506), Expect = 3e-050
Identities = 119/316 (37%), Positives = 183/316 (57%), Gaps = 13/316 (4%)
Frame = +1
Query: 175 FSARSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKE 354
+ +TA E+ G D TG +VTGA+SGIG ETA+ AL G HV++A RN ++
Sbjct: 107 YDGSTTAMEILQGRDFTGKVVLVTGANSGIGFETAKSFALHGAHVILACRNLSRASEAVS 166
Query: 355 DIVNRVPGAKLDVMELDLSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIE 534
I+ AK++ M LDL+ + SV+ FA +K+ L++L+ NAG A P+ L+KD +E
Sbjct: 167 RILEEWHKAKVEAMTLDLAVLRSVQHFAEAFKAKNVSLHVLVCNAGTFALPWGLTKDGLE 226
Query: 535 LQFATNHLGHFLLTKLLLDTMKNTSRESKREGRIVNLSSEAHRFS--YPEGVRFDKIN-- 702
F NHLGHF L +LL D + +S R++ +SSE+HRF+ + D
Sbjct: 227 TTFQVNHLGHFYLVQLLQDVLCRSS-----PARVIVVSSESHRFTDINDSSGKLDLSRLS 281
Query: 703 -DQSSYSSMRAYGQSKLCNVLHANELAKQLKEDGVNITANSLHPGAIMTNLGRYFNSYLA 879
+S Y +M AY +SKLCN+L +NEL ++L GV T+N++HPG +M + + NS++
Sbjct: 282 PPRSDYWAMLAYNRSKLCNILFSNELHRRLSPRGV--TSNAVHPGNMMYS-AIHRNSWVY 338
Query: 880 GAVGAVAKYVLKTVPQGAATACYVALNPQVTGVTGEYFLDSNIAKPLSLAKDSELAKKVW 1059
+ +A+ K++ QGAAT Y A+ P++ G+ G YF + P A+ E A+ +W
Sbjct: 339 KLLFTLARPFTKSMQQGAATTVYCAVAPELEGLGGMYFNNCCRCLPSEEAQSEETARALW 398
Query: 1060 EFSTKLTESQSGESSS 1107
E S +L + + G SS
Sbjct: 399 ELSERLIQDRLGSPSS 414
>sp|Q9NZC7|WWOX_HUMAN WW domain-containing oxidoreductase OS=Homo sapiens
GN=WWOX PE=1 SV=1
Length = 414
Score = 193 bits (488), Expect = 4e-048
Identities = 115/313 (36%), Positives = 182/313 (58%), Gaps = 15/313 (4%)
Frame = +1
Query: 175 FSARSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKE 354
+ +TA E+ G D TG +VTGA+SGIG ETA+ AL G HV++A RN ++
Sbjct: 107 YDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVS 166
Query: 355 DIVNRVPGAKLDVMELDLSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIE 534
I+ AK++ M LDL+ + SV+ FA +K+ PL++L+ NA A P+ L+KD +E
Sbjct: 167 RILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLE 226
Query: 535 LQFATNHLGHFLLTKLLLDTMKNTSRESKREGRIVNLSSEAHRFSYPEG----VRFDKIN 702
F NHLGHF L +LL D + ++ R++ +SSE+HRF+ + F +++
Sbjct: 227 TTFQVNHLGHFYLVQLLQDVLCRSA-----PARVIVVSSESHRFTDINDSLGKLDFSRLS 281
Query: 703 -DQSSYSSMRAYGQSKLCNVLHANELAKQLKEDGVNITANSLHPGAIM-TNLGRYFNSYL 876
++ Y +M AY +SKLCN+L +NEL ++L GV T+N++HPG +M +N+ R + Y
Sbjct: 282 PTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGV--TSNAVHPGNMMYSNIHRSWWVYT 339
Query: 877 AGAVGAVAKYVLKTVPQGAATACYVALNPQVTGVTGEYFLDSNIAKPLSLAKDSELAKKV 1056
+ +A+ K++ QGAAT Y A P++ G+ G YF + P A+ E A+ +
Sbjct: 340 --LLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTL 397
Query: 1057 WEFSTKLTESQSG 1095
W S +L + + G
Sbjct: 398 WALSERLIQERLG 410
>sp|Q5R9W5|WWOX_PONAB WW domain-containing oxidoreductase OS=Pongo abelii
GN=WWOX PE=2 SV=1
Length = 414
Score = 191 bits (485), Expect = 8e-048
Identities = 115/313 (36%), Positives = 182/313 (58%), Gaps = 15/313 (4%)
Frame = +1
Query: 175 FSARSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKE 354
+ +TA E+ G D TG +VTGA+SGIG ETA+ AL G HV++A RN ++
Sbjct: 107 YDGSTTALEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVS 166
Query: 355 DIVNRVPGAKLDVMELDLSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIE 534
I+ AK++ + LDL+ + SV+ FA +K+ PL++L+ NA A P+ L+KD +E
Sbjct: 167 RILEEWHKAKVEAVTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLE 226
Query: 535 LQFATNHLGHFLLTKLLLDTMKNTSRESKREGRIVNLSSEAHRFSYPEG----VRFDKIN 702
F NHLGHF L +LL D + ++ R++ +SSE+HRF+ + F +++
Sbjct: 227 TTFQVNHLGHFYLVQLLQDVLCRSA-----PARVIVVSSESHRFTDINDSLGKLDFSRLS 281
Query: 703 -DQSSYSSMRAYGQSKLCNVLHANELAKQLKEDGVNITANSLHPGAIM-TNLGRYFNSYL 876
++ Y +M AY +SKLCNVL +NEL ++L GV T+N++HPG +M +N+ R + Y
Sbjct: 282 PTKNDYWAMLAYNRSKLCNVLFSNELHRRLSPRGV--TSNAVHPGNMMYSNIHRSWWVYT 339
Query: 877 AGAVGAVAKYVLKTVPQGAATACYVALNPQVTGVTGEYFLDSNIAKPLSLAKDSELAKKV 1056
+ +A+ K++ QGAAT Y A P++ G+ G YF + P A+ E A+ +
Sbjct: 340 --LLFTLARPFTKSMQQGAATTVYCAAAPELEGLGGMYFNNCCRCMPSPEAQSEETARTL 397
Query: 1057 WEFSTKLTESQSG 1095
W S +L + + G
Sbjct: 398 WALSERLIQERLG 410
>sp|Q5F389|WWOX_CHICK WW domain-containing oxidoreductase OS=Gallus gallus
GN=WWOX PE=2 SV=2
Length = 414
Score = 190 bits (481), Expect = 2e-047
Identities = 117/313 (37%), Positives = 181/313 (57%), Gaps = 15/313 (4%)
Frame = +1
Query: 175 FSARSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKE 354
+ STA E+ G D +G I+TGA+SGIG ETA+ AL G +V++A RN G +
Sbjct: 107 YDGNSTAMEILQGRDLSGKVIIITGANSGIGFETAKSFALHGAYVILACRNMSRGNDAVQ 166
Query: 355 DIVNRVPGAKLDVMELDLSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIE 534
I+ AK++ M LDL+S+ SV+ FA +KS PL++L+ NA I + L++D +E
Sbjct: 167 RILEEWHKAKVEAMTLDLASLRSVQNFAEAFKSKNMPLHILVCNAAIFGSSWCLTEDGLE 226
Query: 535 LQFATNHLGHFLLTKLLLDTMKNTSRESKREGRIVNLSSEAHRFSYPEG----VRFDKIN 702
F NHLGHF L +LL D ++ +S R+V +SSE+HRF+ + + F ++
Sbjct: 227 STFQVNHLGHFYLVQLLEDILRRSS-----PARVVVVSSESHRFTEIKDSSGKLDFSLLS 281
Query: 703 -DQSSYSSMRAYGQSKLCNVLHANELAKQLKEDGVNITANSLHPG-AIMTNLGRYFNSYL 876
+ Y +M AY +SKLCN+L +NEL ++L GV T+NS+HPG I +++ R N ++
Sbjct: 282 PSKKEYWAMLAYNRSKLCNILFSNELNRRLSPHGV--TSNSVHPGNMIYSSIHR--NWWV 337
Query: 877 AGAVGAVAKYVLKTVPQGAATACYVALNPQVTGVTGEYFLDSNIAKPLSLAKDSELAKKV 1056
+ +A+ K++ QGAAT Y A ++ G+ G YF + P + A++ A +
Sbjct: 338 YTLLFTLARPFTKSMQQGAATTVYCATAAELEGLGGMYFNNCCRCLPSAEARNELTAVAL 397
Query: 1057 WEFSTKLTESQSG 1095
WE S +L Q G
Sbjct: 398 WELSERLIREQLG 410
>sp|Q803A8|WWOX_DANRE WW domain-containing oxidoreductase OS=Danio rerio GN=wwox
PE=2 SV=1
Length = 412
Score = 190 bits (481), Expect = 2e-047
Identities = 115/312 (36%), Positives = 187/312 (59%), Gaps = 15/312 (4%)
Frame = +1
Query: 175 FSARSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKE 354
+ + A E+ HG D + IVTGA+SGIG ETAR AL G HV++A RN +K
Sbjct: 104 YDGNTGALEILHGQDLSDKVIIVTGANSGIGFETARSFALHGAHVILACRNQSRASKAAS 163
Query: 355 DIVNRVPGAKLDVMELDLSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIE 534
I+ A+++V+ LDL+S+ SVR+FA +K++ PL++L+ NA + + P+ L++D E
Sbjct: 164 LIMGEWSKARVEVLPLDLASLRSVRQFAELFKATKLPLHVLVCNAAVCSQPWRLTEDGFE 223
Query: 535 LQFATNHLGHFLLTKLLLDTMKNTSRESKREGRIVNLSSEAHRFS----YPEGVRFDKIN 702
F HLGHFLL +LL D ++ ++ R+V +SSE+HRF+ + D ++
Sbjct: 224 STFQICHLGHFLLVQLLQDVLRLSA-----PARVVVVSSESHRFTDLLDSCGNLDLDLLS 278
Query: 703 -DQSSYSSMRAYGQSKLCNVLHANELAKQLKEDGVNITANSLHPGAIM-TNLGRYFNSYL 876
Q +Y S+ AY ++KLCN+L ++EL +++ G I N+LHPG++M T++ R + +L
Sbjct: 279 PPQKNYWSLLAYNRAKLCNLLFSSELHRRMSPHG--ICCNALHPGSMMFTSIHRSW--WL 334
Query: 877 AGAVGAVAKYVLKTVPQGAATACYVALNPQVTGVTGEYFLDSNIAKPLSLAKDSELAKKV 1056
+ ++A+ K++ QGAAT Y A+ P++ G+ G YF + P A+D A +
Sbjct: 335 LTLLFSLARPFTKSMQQGAATTVYCAVAPELEGIGGMYFNNCFRCLPSPQAQDPAAALSL 394
Query: 1057 WEFSTKLTESQS 1092
WE S +L + +S
Sbjct: 395 WELSERLVQERS 406
>sp|Q8NBN7|RDH13_HUMAN Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1
SV=2
Length = 331
Score = 180 bits (456), Expect = 2e-044
Identities = 108/289 (37%), Positives = 168/289 (58%), Gaps = 15/289 (5%)
Frame = +1
Query: 226 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAKLDVMELD 405
G T IVTGA++GIG +TA LA RG ++++A R+ +DI ++ LD
Sbjct: 38 GKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLD 97
Query: 406 LSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHFLLTKLL 585
L+S+ S+R+FA+ +++LINNAG+M CP ++D E+QF NHLGHFLLT LL
Sbjct: 98 LASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLL 157
Query: 586 LDTMKNTSRESKREGRIVNLSSEAHRFSYPEGVRFDKINDQS-SYSSMRAYGQSKLCNVL 762
LD +K + RI+NLSS AH + + FD +N Q+ Y++ AY QSKL VL
Sbjct: 158 LDKLK-----ASAPSRIINLSSLAHVAGH---IDFDDLNWQTRKYNTKAAYCQSKLAIVL 209
Query: 763 HANELAKQLKEDGVNITANSLHPGAIMTNLGRYF----NSYLAGAVGAVAKYVLKTVPQG 930
EL+++L+ GV T N+LHPG T LGR+ +++ + +G + ++K+
Sbjct: 210 FTKELSRRLQGSGV--TVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSPELA 267
Query: 931 AATACYVALNPQVTGVTGEYFLDSNIAKPLSLAKDSELAKKVWEFSTKL 1077
A + Y+A+ ++ V+G+YF P A+D E+A+++W S +L
Sbjct: 268 AQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARL 316
>sp|Q8VBZ0|DHRSX_MOUSE Dehydrogenase/reductase SDR family member on chromosome X
homolog OS=Mus musculus GN=Dhrsx PE=2 SV=2
Length = 335
Score = 175 bits (443), Expect = 6e-043
Identities = 111/292 (38%), Positives = 158/292 (54%), Gaps = 4/292 (1%)
Frame = +1
Query: 226 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAKLDVMELD 405
G AIVTGA++GIG TAR LA G+ VV+A + G +V I + + + LD
Sbjct: 43 GRVAIVTGATAGIGRSTARQLARLGMCVVVAGNDEHRGQEVVSSIRAEMGSDRAHFLPLD 102
Query: 406 LSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHFLLTKLL 585
L+S+ SVR FA D+++ G PL+LL+NNAG+M P ++D E N LGHFLLT LL
Sbjct: 103 LASLASVRGFARDFQALGLPLHLLVNNAGVMLEPRAETEDGFERHLGVNFLGHFLLTLLL 162
Query: 586 LDTMKNTSRESKREGRIVNLSSEAHRFSYPEGVRFDKINDQSSYSSMRAYGQSKLCNVLH 765
L ++ + E R R+V + S H Y V ++ + +YS AY QSKL L
Sbjct: 163 LPALRASGAEG-RGSRVVTVGSATH---YVGTVDMADLHGRHAYSPYAAYAQSKLALALF 218
Query: 766 ANELAKQLKEDGVNITANSLHPGAIMTNLGRYFNSYLAGAVGAVAKYVLKTVPQGAATAC 945
A +L + L G +T+N PG + T L R+ L A + V K+ +GA T
Sbjct: 219 ALQLQRILDARGDPVTSNMADPGVVDTELYRHAGWVLRTAKRFLGWLVFKSPEEGAWTLV 278
Query: 946 YVALNPQVTGVTGEYFLDSNIAKPLSLAKDSELAKKVWEFSTKLTESQSGES 1101
Y A P++ GV G Y D A+PL A+D EL +++W +LT + G+S
Sbjct: 279 YAAAAPELEGVGGRYLRDEAEAEPLGTARDQELQRRLWAEGLRLTGAGGGDS 330
>sp|Q9VLU5|WWOX_DROME WW domain-containing oxidoreductase OS=Drosophila
melanogaster GN=Wwox PE=2 SV=1
Length = 409
Score = 175 bits (443), Expect = 6e-043
Identities = 116/307 (37%), Positives = 174/307 (56%), Gaps = 17/307 (5%)
Frame = +1
Query: 175 FSARSTAEEVTHGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKE 354
F + STA +V HG D G TA++TGA+ GIG ETAR LA G ++ A RN S E
Sbjct: 104 FDSCSTALQVLHGKDLHGRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIE 163
Query: 355 DIVNRVPGA--KLDVMELDLSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDN 528
I P A + LDLSS+ SV++F + K S ++ LI NAG+ A P+ + D
Sbjct: 164 RIAQERPAARSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDG 223
Query: 529 IELQFATNHLGHFLLTKLLLDTMKNTSRESKREGRIVNLSSEAHRFSY--PEGVRFDKIN 702
+E F +HL HF LT L L+T+ + + RI+ LSSE+HRF+ E + ++
Sbjct: 224 LETTFQVSHLSHFYLT-LQLETLFD------YKTRIIVLSSESHRFANLPVENLAVHHLS 276
Query: 703 -DQSSYSSMRAYGQSKLCNVLHANELAKQLKEDGVNITANSLHPG-AIMTNLGRYFNSYL 876
Y SM AY +KLCNVL A ELA++ K+ G+++ SLHPG + ++L R N +
Sbjct: 277 PPPEKYWSMMAYNNAKLCNVLFAQELAQRWKQRGISVF--SLHPGNMVSSDLSR--NYWF 332
Query: 877 AGAVGAVAKYVLKTVPQGAATACYVALNPQVTGVTGEYFLDSNIAKPLSLAKDSELAKKV 1056
+ A+ + K++ Q AAT+ Y A ++TG++G YF + +P L+K + L +++
Sbjct: 333 YRLLFAIVRPFTKSLQQAAATSIYCATANELTGLSGLYFNNCFFCEPSKLSKSAALQQQL 392
Query: 1057 WEFSTKL 1077
W+ S L
Sbjct: 393 WKLSENL 399
>sp|Q8N5I4|DHRSX_HUMAN Dehydrogenase/reductase SDR family member on chromosome X
OS=Homo sapiens GN=DHRSX PE=2 SV=2
Length = 330
Score = 173 bits (438), Expect = 2e-042
Identities = 101/282 (35%), Positives = 152/282 (53%), Gaps = 4/282 (1%)
Frame = +1
Query: 235 AIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAKLDVMELDLSS 414
AIVTG + GIG TA+ LA G+HV++A N +V I K++ + DL+S
Sbjct: 46 AIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLAS 105
Query: 415 MDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHFLLTKLLLDT 594
M S+R+F +K PL++LINNAG+M P ++D E F N+LGHFLLT LLLDT
Sbjct: 106 MTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLLDT 165
Query: 595 MKNTSRESKREGRIVNLSSEAHRFSYPEGVRFDKINDQSSYSSMRAYGQSKLCNVLHANE 774
+K S R+V +SS H Y + D + + YS AY QSKL VL
Sbjct: 166 LKE-SGSPGHSARVVTVSSATH---YVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYH 221
Query: 775 LAKQLKEDGVNITANSLHPGAIMTNLGRYFNSYLAGAVGAVAKYVLKTVPQGAATACYVA 954
L + L +G ++TAN + PG + T++ ++ A + + KT +GA T+ Y A
Sbjct: 222 LQRLLAAEGSHVTANVVDPGVVNTDVYKHVFWATRLAKKLLGWLLFKTPDEGAWTSIYAA 281
Query: 955 LNPQVTGVTGEYFLDSNIAKPLSLAKDSELAKKVWEFSTKLT 1080
+ P++ GV G Y + K L + + +L +++W S ++T
Sbjct: 282 VTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMT 323
>sp|Q8CEE7|RDH13_MOUSE Retinol dehydrogenase 13 OS=Mus musculus GN=Rdh13 PE=2
SV=1
Length = 334
Score = 170 bits (430), Expect = 2e-041
Identities = 110/289 (38%), Positives = 163/289 (56%), Gaps = 15/289 (5%)
Frame = +1
Query: 226 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAKLDVMELD 405
G T IVTGA++GIG +TA LA RG +V++A R+ +DI ++ LD
Sbjct: 38 GKTVIVTGANTGIGKQTALELAKRGGNVILACRDMEKCEVAAKDIRGETLNPRVRAERLD 97
Query: 406 LSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHFLLTKLL 585
L+S+ S+R+FA +++L+NNA +M CP ++D E+QF N+LGHFLLT LL
Sbjct: 98 LASLKSIREFARKVIKEEERVDILVNNAAVMRCPHWTTEDGFEMQFGVNYLGHFLLTNLL 157
Query: 586 LDTMKNTSRESKREGRIVNLSSEAHRFSYPEGVRFDKINDQ-SSYSSMRAYGQSKLCNVL 762
LD +K + RI+NLSS AH + + F+ +N Q Y + AY QSKL VL
Sbjct: 158 LDKLK-----ASAPSRIINLSSLAHVAGH---IDFEDLNWQMKKYDTKAAYCQSKLAVVL 209
Query: 763 HANELAKQLKEDGVNITANSLHPGAIMTNLGRY---FNSYLAGAVGAVAKYVLKTVPQGA 933
EL+ +L+ GV T N+LHPG T LGR+ NS +G + ++L PQ A
Sbjct: 210 FTKELSHRLQGSGV--TVNALHPGVARTELGRHTGMHNSAFSGFMLGPFFWLLFKSPQLA 267
Query: 934 A-TACYVALNPQVTGVTGEYFLDSNIAKPLSLAKDSELAKKVWEFSTKL 1077
A + Y+A+ ++ V+G+YF P A+D E+A+++W S +L
Sbjct: 268 AQPSTYLAVAEELENVSGKYFDGLREKAPSPEAEDEEVARRLWTESARL 316
>sp|O74959|YJCD_SCHPO Uncharacterized oxidoreductase C736.13
OS=Schizosaccharomyces pombe GN=SPCC736.13 PE=2 SV=1
Length = 339
Score = 159 bits (400), Expect = 6e-038
Identities = 107/294 (36%), Positives = 166/294 (56%), Gaps = 7/294 (2%)
Frame = +1
Query: 217 DGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAKLDVM 396
D TG A+VTG+S GIG TA LA +G V +A RN KV + I + V +K+ +
Sbjct: 39 DLTGKVALVTGSSGGIGYVTALELARKGAKVYLAGRNEEKYQKVMKQIHDEVRHSKIRFL 98
Query: 397 ELDLSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHFLLT 576
LDL +SV + A + + L++L+NNAGIM PF L+KD ELQ TN+L H+L T
Sbjct: 99 RLDLLDFESVYQAAESFIAKEEKLHILVNNAGIMNPPFELTKDGYELQIQTNYLSHYLFT 158
Query: 577 KLLLDTMKNTSRESK-REGRIVNLSSEAHRFSYPEGVRFDKIN-DQSSYSSMRAYGQSKL 750
+LLL T++ T+ E + + RIV+++S A+ + G+ F +N + YGQSK
Sbjct: 159 ELLLPTLRRTAEECRPGDVRIVHVASIAYLQAPYSGIYFPDLNLPHVLLGTFARYGQSKY 218
Query: 751 CNVLHANELAKQLKEDGVNITANSLHPGAIMTNLGRYFNSY-LAGAVGAVAKYVLKTVPQ 927
+L++ LAK+L++ G I + SLHPG I T L RY ++ L +V +Y+L +
Sbjct: 219 AQILYSIALAKRLEKYG--IYSVSLHPGVIRTELTRYSPTFALKLLEKSVFQYLLLDPIR 276
Query: 928 GAATACYVALNPQVT--GVTGEYFLDSNIAKPLSLAKDSELAKKVWEFSTKLTE 1083
GA T+ Y A +P+++ + G YF L A D ++++ ++ K+ E
Sbjct: 277 GAMTSLYAATSPEISKEHLNGAYFTAIAQRGILHRAHDDAFVEELYRYTHKIFE 330
>sp|Q5SS80|DHR13_MOUSE Dehydrogenase/reductase SDR family member 13 OS=Mus
musculus GN=Dhrs13 PE=1 SV=1
Length = 376
Score = 151 bits (380), Expect = 1e-035
Identities = 103/292 (35%), Positives = 156/292 (53%), Gaps = 11/292 (3%)
Frame = +1
Query: 226 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAKLDVMELD 405
G T +VTGA+SGIG TA LA RG VV+A R+ G D+ ++ M LD
Sbjct: 36 GRTVVVTGANSGIGKMTALELARRGARVVLACRSRERGEAAAFDLRQESGNNEVIFMALD 95
Query: 406 LSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHFLLTKLL 585
L+S+ SV+ FA+ + SS L++LI+NAGI +C +++ L NH+G FLLT LL
Sbjct: 96 LASLASVQAFATAFLSSEPRLDVLIHNAGISSCG--RTRETFNLLLRVNHVGPFLLTHLL 153
Query: 586 LDTMKNTSRESKREGRIVNLSSEAHRFSYPEGVRFDKINDQSSYSSMRAYGQSKLCNVLH 765
L +++ + R+V +SS AHR + R D +RAY SKL NVL
Sbjct: 154 LPRLRSCA-----PSRVVIVSSAAHRRGRLDFTRLD-CPVVGWQQELRAYADSKLANVLF 207
Query: 766 ANELAKQLKEDGVNITANSLHPGAIMTNLG-RYFNSYLAGAVGAVAKYVLKTVPQGAATA 942
A ELA QL +G +T + HPG + + L R+ +L + +A VL+ GA T
Sbjct: 208 ARELATQL--EGTGVTCYAAHPGPVNSELFLRHLPGWLRPILRPLAWLVLRAPQGGAQTP 265
Query: 943 CYVALNPQVTGVTGEYFLDSNIAKPLSLAKDSELAKKVWEFSTKLTESQSGE 1098
Y AL + ++G YF + ++ + A+D + A+++W+ + KL G+
Sbjct: 266 LYCALQEGIEPLSGRYFANCHVEEVSPAARDDQAAQRLWKATKKLAGLAPGD 317
>sp|Q03326|OXIR_STRAT Probable oxidoreductase OS=Streptomyces antibioticus PE=3
SV=1
Length = 298
Score = 137 bits (343), Expect = 2e-031
Identities = 108/308 (35%), Positives = 154/308 (50%), Gaps = 38/308 (12%)
Frame = +1
Query: 214 VDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAKLDV 393
+D TG A+VTG +SG+G ET R LA G V +A R S + +++ ++
Sbjct: 1 MDLTGRRAVVTGGASGLGAETVRALAAAGAEVTVATRRPLSAEPLVQELAAAGGAGRVTA 60
Query: 394 MELDLSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPF-MLSKDNIELQFATNHLGHFL 570
LDLS SV FA ++ PL++L+ NAGIMA P L+ + E+Q ATN+LGHF
Sbjct: 61 EALDLSDPASVESFARAWRG---PLDILVANAGIMALPTRTLAPNGWEMQLATNYLGHFA 117
Query: 571 LTKLLLDTMKNTSRESKREGRIVNLSSEAH---RFSYPEGVRFDKINDQSSYSSMRAYGQ 741
L L +++ RIV +SS AH F + E F + Y AYGQ
Sbjct: 118 LATGLHAALRDAG-----SARIVVVSSGAHLDAPFDF-EDAHFAR----RPYDPWVAYGQ 167
Query: 742 SKLCNVLHANELAKQLKEDGVNITANSLHPGAIMTNLGRYFNSYLAGAVGAVAKY----- 906
SK +VL A++ DG IT N+L+PG I+T L R+ + A G +
Sbjct: 168 SKAADVLFTVG-ARRWAADG--ITVNALNPGYILTRLQRHVDDETMRAFGVMDDQGNVKP 224
Query: 907 --VLKTVPQGAATACYVALNPQVTGVTGEYFLDSNIAKPL-----------SLAKDSELA 1047
KT QGAAT+ +A +P + GVTG YF D+ A+ + + A D E A
Sbjct: 225 LPYYKTPEQGAATSVLLAASPLLKGVTGRYFEDNQEARTVQGQEDQPGGVAAHALDPEAA 284
Query: 1048 KKVWEFST 1071
++WE+ T
Sbjct: 285 DRLWEYGT 292
>sp|Q17QU7|DHR13_BOVIN Dehydrogenase/reductase SDR family member 13 OS=Bos
taurus GN=DHRS13 PE=2 SV=1
Length = 377
Score = 125 bits (313), Expect = 7e-028
Identities = 85/209 (40%), Positives = 116/209 (55%), Gaps = 10/209 (4%)
Frame = +1
Query: 226 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAKLDVMELD 405
G TA+VTGA+SGIG TA LA RG VV+A R+ G D+ ++ M LD
Sbjct: 36 GRTAVVTGANSGIGKMTALELARRGARVVLACRSRERGEAAAFDLRQESGNNEVIFMALD 95
Query: 406 LSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHFLLTKLL 585
L+S+ SVR FA+ + SS L++LI+NAGI +C +++ L NH+G FLLT LL
Sbjct: 96 LASLASVRAFATAFLSSEPRLDILIHNAGISSCG--RTREPFNLLLRVNHIGPFLLTHLL 153
Query: 586 LDTMKNTSRESKREGRIVNLSSEAHRFSYPEGVRFDKINDQSSYSSMRAYGQSKLCNVLH 765
L +K ++ R+V +SS AHR + R D +RAY SKL NVL
Sbjct: 154 LPRLKTSA-----PSRVVVVSSAAHRRGRLDFTRLDH-PVVGWQQELRAYANSKLANVLF 207
Query: 766 ANELAKQLKEDGVNITANSLHPGAIMTNL 852
A ELA QL +G +T + HPG + + L
Sbjct: 208 ARELATQL--EGTGVTCYAAHPGPVNSEL 234
>sp|Q9QYF1|RDH11_MOUSE Retinol dehydrogenase 11 OS=Mus musculus GN=Rdh11 PE=2
SV=2
Length = 316
Score = 121 bits (302), Expect = 1e-026
Identities = 67/152 (44%), Positives = 91/152 (59%), Gaps = 5/152 (3%)
Frame = +1
Query: 205 THGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAK 384
T V G AIVTGA++GIG ETA+ LA RG V +A R+ G +I ++
Sbjct: 31 TSNVQLPGKVAIVTGANTGIGKETAKDLAQRGARVYLACRDVDKGELAAREIQAVTGNSQ 90
Query: 385 LDVMELDLSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGH 564
+ V +LDL+ S+R FA D+ + + L+LLINNAG+M CP+ + D E+ NHLGH
Sbjct: 91 VFVRKLDLADTKSIRAFAKDFLAEEKHLHLLINNAGVMMCPYSKTADGFEMHIGVNHLGH 150
Query: 565 FLLTKLLLDTMKNTSRESKREGRIVNLSSEAH 660
FLLT LLL+ +K ++ RIVNLSS H
Sbjct: 151 FLLTHLLLEKLKESA-----PSRIVNLSSLGH 177
>sp|Q8BYK4|RDH12_MOUSE Retinol dehydrogenase 12 OS=Mus musculus GN=Rdh12 PE=2
SV=1
Length = 316
Score = 119 bits (296), Expect = 7e-026
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 5/152 (3%)
Frame = +1
Query: 205 THGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAK 384
T V G ++TGA++GIG ETAR LA RG V +A R+ G +I ++
Sbjct: 32 TTNVQIPGKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIRADTKNSQ 91
Query: 385 LDVMELDLSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGH 564
+ V +LDLS S+R FA + + + L++LINNAG+M CP+ + D E F NHLGH
Sbjct: 92 VLVRKLDLSDTKSIRAFAERFLAEEKKLHILINNAGVMMCPYSKTTDGFETHFGVNHLGH 151
Query: 565 FLLTKLLLDTMKNTSRESKREGRIVNLSSEAH 660
FLLT LLL+ +K ++ R+VNLSS AH
Sbjct: 152 FLLTYLLLERLKESA-----PARVVNLSSIAH 178
>sp|Q8TC12|RDH11_HUMAN Retinol dehydrogenase 11 OS=Homo sapiens GN=RDH11 PE=1
SV=2
Length = 318
Score = 118 bits (295), Expect = 9e-026
Identities = 65/152 (42%), Positives = 91/152 (59%), Gaps = 5/152 (3%)
Frame = +1
Query: 205 THGVDGTGLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAK 384
T V G +VTGA++GIG ETA+ LA RG V +A R+ G V ++I +
Sbjct: 34 TSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQ 93
Query: 385 LDVMELDLSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGH 564
+ V +LDLS S+R FA + + + L++LINNAG+M CP+ + D E+ NHLGH
Sbjct: 94 VLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGH 153
Query: 565 FLLTKLLLDTMKNTSRESKREGRIVNLSSEAH 660
FLLT LLL+ +K ++ RIVN+SS AH
Sbjct: 154 FLLTHLLLEKLKESA-----PSRIVNVSSLAH 180
>sp|Q6UX07|DHR13_HUMAN Dehydrogenase/reductase SDR family member 13 OS=Homo
sapiens GN=DHRS13 PE=1 SV=1
Length = 377
Score = 118 bits (294), Expect = 1e-025
Identities = 83/209 (39%), Positives = 115/209 (55%), Gaps = 10/209 (4%)
Frame = +1
Query: 226 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAKLDVMELD 405
G TA+VTGA+SGIG TA LA RG VV+A R+ G D+ ++ M LD
Sbjct: 36 GRTAVVTGANSGIGKMTALELARRGARVVLACRSQERGEAAAFDLRQESGNNEVIFMALD 95
Query: 406 LSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHFLLTKLL 585
L+S+ SVR FA+ + SS L++LI+NAGI +C +++ L NH+G FLLT LL
Sbjct: 96 LASLASVRAFATAFLSSEPRLDILIHNAGISSCG--RTREAFNLLLRVNHIGPFLLTHLL 153
Query: 586 LDTMKNTSRESKREGRIVNLSSEAHRFSYPEGVRFDKINDQSSYSSMRAYGQSKLCNVLH 765
L +K + R+V ++S AH + R D+ +RAY +KL NVL
Sbjct: 154 LPCLKACA-----PSRVVVVASAAHCRGRLDFKRLDR-PVVGWRQELRAYADTKLANVLF 207
Query: 766 ANELAKQLKEDGVNITANSLHPGAIMTNL 852
A ELA QL+ GV T + HPG + + L
Sbjct: 208 ARELANQLEATGV--TCYAAHPGPVNSEL 234
>sp|P59837|RDH12_BOVIN Retinol dehydrogenase 12 OS=Bos taurus GN=RDH12 PE=2
SV=1
Length = 316
Score = 117 bits (293), Expect = 2e-025
Identities = 63/145 (43%), Positives = 87/145 (60%), Gaps = 5/145 (3%)
Frame = +1
Query: 226 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAKLDVMELD 405
G ++TGA++GIG ETAR LA RG V +A R+ G +I +++ V +LD
Sbjct: 39 GKVVVITGANTGIGKETARELARRGARVYIACRDVLKGESAASEIQADTKNSQVLVRKLD 98
Query: 406 LSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHFLLTKLL 585
LS S+R FA + + + L++LINNAG+M CP+ + D E A NHLGHFLLT LL
Sbjct: 99 LSDTKSIRAFAEGFLAEEKQLHILINNAGVMLCPYSKTADGFETHLAVNHLGHFLLTHLL 158
Query: 586 LDTMKNTSRESKREGRIVNLSSEAH 660
L +K ++ R+VNLSS AH
Sbjct: 159 LGRLKESA-----PARVVNLSSVAH 178
>sp|Q96NR8|RDH12_HUMAN Retinol dehydrogenase 12 OS=Homo sapiens GN=RDH12 PE=1
SV=3
Length = 316
Score = 114 bits (283), Expect = 2e-024
Identities = 61/145 (42%), Positives = 87/145 (60%), Gaps = 5/145 (3%)
Frame = +1
Query: 226 GLTAIVTGASSGIGVETARVLALRGVHVVMAVRNTGSGAKVKEDIVNRVPGAKLDVMELD 405
G ++TGA++GIG ETAR LA RG V +A R+ G +I +++ V +LD
Sbjct: 39 GKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLD 98
Query: 406 LSSMDSVRKFASDYKSSGRPLNLLINNAGIMACPFMLSKDNIELQFATNHLGHFLLTKLL 585
LS S+R FA + + + L++LINNAG+M CP+ + D E NHLGHFLLT LL
Sbjct: 99 LSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLL 158
Query: 586 LDTMKNTSRESKREGRIVNLSSEAH 660
L+ +K ++ R+VN+SS AH
Sbjct: 159 LERLKVSA-----PARVVNVSSVAH 178
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,892,683,958
Number of Sequences: 518415
Number of Extensions: 92892683958
Number of Successful Extensions: 611291351
Number of sequences better than 0.0: 0
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