BLASTX 7.6.2
Query= UN22193 /QuerySize=1238
(1237 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9ES53|UFD1_RAT Ubiquitin fusion degradation protein 1 homolo... 247 2e-064
sp|P70362|UFD1_MOUSE Ubiquitin fusion degradation protein 1 homo... 245 8e-064
sp|Q92890|UFD1_HUMAN Ubiquitin fusion degradation protein 1 homo... 244 1e-063
sp|Q55BK0|UFD1_DICDI Ubiquitin fusion degradation protein 1 homo... 236 3e-061
sp|Q9VTF9|UFD1_DROME Ubiquitin fusion degradation protein 1 homo... 225 9e-058
sp|O42915|UFD1_SCHPO Ubiquitin fusion degradation protein 1 OS=S... 193 2e-048
sp|P53044|UFD1_YEAST Ubiquitin fusion degradation protein 1 OS=S... 186 5e-046
sp|Q19584|UFD1_CAEEL Ubiquitin fusion degradation protein 1 homo... 181 1e-044
>sp|Q9ES53|UFD1_RAT Ubiquitin fusion degradation protein 1 homolog OS=Rattus
norvegicus GN=Ufd1l PE=1 SV=1
Length = 307
Score = 247 bits (629), Expect = 2e-064
Identities = 122/231 (52%), Positives = 159/231 (68%), Gaps = 6/231 (2%)
Frame = -1
Query: 1093 FEQSYRCYPASFI----DKPQIESGDKIIMPPSALDRLASLHIDYPMLFELRNAGIERVS 926
F YRC+ S + D+ +E G KIIMPPSALD+L+ L+I YPMLF+L N +R++
Sbjct: 19 FSTQYRCFSVSMLAGPNDRSDVEKGGKIIMPPSALDQLSRLNITYPMLFKLTNKNSDRMT 78
Query: 925 HCGVLEFIAEEGMIYMPYWMMQNLLLQEGDIVRVRNVTLPKGTYVKLQPHTTDFLDISNP 746
HCGVLEF+A+EG+ Y+P+WMMQNLLL+EG +V+V +V L TY K QP + DFLDI+NP
Sbjct: 79 HCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQVESVNLQVATYSKFQPQSPDFLDITNP 138
Query: 745 KAILETALRNYSCLTTGDSIMVPYNNKKYFIDIVETKPANGISIIETDCEVDFAPPLDYK 566
KA+LE ALRN++CLTTGD I + YN K Y + ++ETKP +SIIE D VDF PL YK
Sbjct: 139 KAVLENALRNFACLTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPLGYK 198
Query: 565 EPERPKTAPAAAKGPAKAEEVVPEPEPKFNPFTGSGRRLDGRPLSYEPPPA 413
EPERP + +G +A+ E F F+GSG RLDG+ EP P+
Sbjct: 199 EPERPVQHEESIEG--EADHSGYAGEVGFRAFSGSGNRLDGKKKGVEPSPS 247
>sp|P70362|UFD1_MOUSE Ubiquitin fusion degradation protein 1 homolog OS=Mus
musculus GN=Ufd1l PE=1 SV=1
Length = 307
Score = 245 bits (623), Expect = 8e-064
Identities = 120/231 (51%), Positives = 159/231 (68%), Gaps = 6/231 (2%)
Frame = -1
Query: 1093 FEQSYRCYPASFI----DKPQIESGDKIIMPPSALDRLASLHIDYPMLFELRNAGIERVS 926
F YRC+ S + D+ +E G KIIMPPSALD+L+ L+I YPMLF+L N +R++
Sbjct: 19 FSTQYRCFSVSMLAGPNDRSDVEKGGKIIMPPSALDQLSRLNITYPMLFKLTNKNSDRMT 78
Query: 925 HCGVLEFIAEEGMIYMPYWMMQNLLLQEGDIVRVRNVTLPKGTYVKLQPHTTDFLDISNP 746
HCGVLEF+A+EG+ Y+P+WMMQNLLL+EG +V+V +V L TY K QP + DFLDI+NP
Sbjct: 79 HCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQVESVNLQVATYSKFQPQSPDFLDITNP 138
Query: 745 KAILETALRNYSCLTTGDSIMVPYNNKKYFIDIVETKPANGISIIETDCEVDFAPPLDYK 566
KA+LE ALRN++C+TTGD I + YN K Y + ++ETKP +SIIE D VDF PL YK
Sbjct: 139 KAVLENALRNFACMTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPLGYK 198
Query: 565 EPERPKTAPAAAKGPAKAEEVVPEPEPKFNPFTGSGRRLDGRPLSYEPPPA 413
EP+RP + +G +A+ E F F+GSG RLDG+ EP P+
Sbjct: 199 EPKRPVQHEESIEG--EADHSGYAGEVGFRAFSGSGNRLDGKKKGVEPSPS 247
>sp|Q92890|UFD1_HUMAN Ubiquitin fusion degradation protein 1 homolog OS=Homo
sapiens GN=UFD1L PE=1 SV=3
Length = 307
Score = 244 bits (621), Expect = 1e-063
Identities = 121/231 (52%), Positives = 158/231 (68%), Gaps = 6/231 (2%)
Frame = -1
Query: 1093 FEQSYRCYPASFI----DKPQIESGDKIIMPPSALDRLASLHIDYPMLFELRNAGIERVS 926
F YRC+ S + D+ +E G KIIMPPSALD+L+ L+I YPMLF+L N +R++
Sbjct: 19 FSTQYRCFSVSMLAGPNDRSDVEKGGKIIMPPSALDQLSRLNITYPMLFKLTNKNSDRMT 78
Query: 925 HCGVLEFIAEEGMIYMPYWMMQNLLLQEGDIVRVRNVTLPKGTYVKLQPHTTDFLDISNP 746
HCGVLEF+A+EG+ Y+P+WMMQNLLL+EG +V+V +V L TY K QP + DFLDI+NP
Sbjct: 79 HCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQVESVNLQVATYSKFQPQSPDFLDITNP 138
Query: 745 KAILETALRNYSCLTTGDSIMVPYNNKKYFIDIVETKPANGISIIETDCEVDFAPPLDYK 566
KA+LE ALRN++CLTTGD I + YN K Y + ++ETKP +SIIE D VDF PL YK
Sbjct: 139 KAVLENALRNFACLTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPLGYK 198
Query: 565 EPERPKTAPAAAKGPAKAEEVVPEPEPKFNPFTGSGRRLDGRPLSYEPPPA 413
EPER + +G +A+ E F F+GSG RLDG+ EP P+
Sbjct: 199 EPERQVQHEESTEG--EADHSGYAGELGFRAFSGSGNRLDGKKKGVEPSPS 247
>sp|Q55BK0|UFD1_DICDI Ubiquitin fusion degradation protein 1 homolog
OS=Dictyostelium discoideum GN=ufd1 PE=3 SV=1
Length = 330
Score = 236 bits (601), Expect = 3e-061
Identities = 120/251 (47%), Positives = 165/251 (65%), Gaps = 13/251 (5%)
Frame = -1
Query: 1117 GYHYPGT-TFEQSYRCYPASFI--DKPQIESGDKIIMPPSALDRLASLHIDYPMLFELRN 947
G+H+ G +EQ ++ +P SF+ +K +ESG KI++PPSAL+ L+ L+I YPMLFE+ N
Sbjct: 16 GHHHGGPGRYEQKFKAFPISFLPKEKHSLESGGKILLPPSALNALSRLNIQYPMLFEISN 75
Query: 946 AGIERVSHCGVLEFIAEEGMIYMPYWMMQNLLLQEGDIVRVRNVTLPKGTYVKLQPHTTD 767
+ SHCGVLEFIAEEG+ Y+P WMMQNL L+EG+ + ++N TL KGT+VK+QP T++
Sbjct: 76 PISGKKSHCGVLEFIAEEGICYLPLWMMQNLQLKEGEFIDIKNATLAKGTFVKIQPRTSN 135
Query: 766 FLDISNPKAILETALRNYSCLTTGDSIMVPYNNKKYFIDIVETKPANGISIIETDCEVDF 587
F+DISNPKA+LE +LR ++ LT D IM+ YNN KY++ +VE KPAN ISIIE D VDF
Sbjct: 136 FIDISNPKAVLENSLRKFATLTKDDEIMIDYNNTKYYLKVVELKPANAISIIEADVSVDF 195
Query: 586 APPLDYKEPERPKTAPAAA--KGPAKAEEVVPEPEPKFNPFTGSGRRLDGRPLSYEPPPA 413
APP+D KE P T+ + GP+K F P + S + + G + +
Sbjct: 196 APPMDSKEATSPSTSSPGSHVSGPSKG--------LTFGPASTSAKPIPGGKKKKDESDS 247
Query: 412 SSSSSSSSKDK 380
S S K K
Sbjct: 248 DSDSDDEPKFK 258
>sp|Q9VTF9|UFD1_DROME Ubiquitin fusion degradation protein 1 homolog
OS=Drosophila melanogaster GN=Ufd1-like PE=1 SV=1
Length = 316
Score = 225 bits (571), Expect = 9e-058
Identities = 116/247 (46%), Positives = 158/247 (63%), Gaps = 26/247 (10%)
Frame = -1
Query: 1123 FDGYH--YP-GTTFEQSYRCYPASFI---DKPQIESGDKIIMPPSALDRLASLHIDYPML 962
F G++ +P G F +Y+C+ S + ++ +E G KIIMPPSALD L L+++YPML
Sbjct: 4 FSGFNMMFPEGRNFHANYKCFSVSMLPGNERTDVEKGGKIIMPPSALDTLTRLNVEYPML 63
Query: 961 FELRNAGIERVSHCGVLEFIAEEGMIYMPYWMMQNLLLQEGDIVRVRNVTLPKGTYVKLQ 782
F+L N R SH GVLEF+A+EG Y+P+WMM+NLLL EGDI+ + +V+LP T+ K Q
Sbjct: 64 FKLTNVKKSRSSHAGVLEFVADEGKCYLPHWMMENLLLGEGDILNIESVSLPVATFSKFQ 123
Query: 781 PHTTDFLDISNPKAILETALRNYSCLTTGDSIMVPYNNKKYFIDIVETKPANGISIIETD 602
PH+TDFLDI+NPKA+LE ALRN++CLT GD I + YN K Y + ++ETKP N +SIIE D
Sbjct: 124 PHSTDFLDITNPKAVLENALRNFACLTRGDVIAIKYNKKVYELCVLETKPGNAVSIIECD 183
Query: 601 CEVDFAPPLDYKEPERPKTAPAAAKGPAKA-------------EEVVPEPEPKFNPFTGS 461
V+F P+ YK+ + + + +G A EEVV F GS
Sbjct: 184 MNVEFEAPVGYKDHSETQASGSGQQGAAGTVGGEIAGATNAILEEVV-------ETFKGS 236
Query: 460 GRRLDGR 440
G RLDG+
Sbjct: 237 GVRLDGK 243
>sp|O42915|UFD1_SCHPO Ubiquitin fusion degradation protein 1
OS=Schizosaccharomyces pombe GN=ufd1 PE=2 SV=4
Length = 342
Score = 193 bits (490), Expect = 2e-048
Identities = 98/236 (41%), Positives = 153/236 (64%), Gaps = 14/236 (5%)
Frame = -1
Query: 1093 FEQSYRCYPASFI---DKPQIESGDKIIMPPSALDRLASLHIDYPMLFELRNAGIERVSH 923
F+ YRCYP + I ++P + G K+I+PPSAL++L+ L++ YPMLF+ N E+ +H
Sbjct: 32 FDTRYRCYPVAMIPGEERPNVNYGGKVILPPSALEKLSRLNVSYPMLFDFENEAAEKKTH 91
Query: 922 CGVLEFIAEEGMIYMPYWMMQNLLLQEGDIVRVRNVTLPKGTYVKLQPHTTDFLDISNPK 743
GVLEFIAEEG +Y+PYWMM L L+ GD+VRV N + +G+YVKLQP + +FLDI++ +
Sbjct: 92 GGVLEFIAEEGRVYLPYWMMTTLSLEPGDLVRVINTDIAQGSYVKLQPQSVNFLDITDHR 151
Query: 742 AILETALRNYSCLTTGDSIMVPYNNKKYFIDIVETKPANG---ISIIETDCEVDFAPPLD 572
A+LE ALRN+S LT D + YN++ Y I +++ +P + +S++ETD VDF PP+
Sbjct: 152 AVLENALRNFSTLTKSDIFEILYNDQVYQIKVIDVQPDDSRHVVSVVETDLVVDFDPPIG 211
Query: 571 YKE--PERPKTAPAAAKGPAKA----EEVVPEPEPKFNPFTGSGRRLDGRPLSYEP 422
Y+E + + A +G +E+V + + N G+G +L+G+ ++ P
Sbjct: 212 YEESLQKNKQQNIAGVQGTMVTKIGYDELVRQGDS--NLMKGTGTKLNGKEVAEVP 265
>sp|P53044|UFD1_YEAST Ubiquitin fusion degradation protein 1 OS=Saccharomyces
cerevisiae GN=UFD1 PE=1 SV=1
Length = 361
Score = 186 bits (470), Expect = 5e-046
Identities = 93/187 (49%), Positives = 125/187 (66%), Gaps = 7/187 (3%)
Frame = -1
Query: 1096 TFEQSYRCYPASF----IDKPQIESGDKIIMPPSALDRLASLHIDYPMLFELRNAGIERV 929
TFE+ +RCYP + I K G KI +PPSAL +L+ L+I YPMLF+L RV
Sbjct: 20 TFEEFFRCYPIAMMNDRIRKDDANFGGKIFLPPSALSKLSMLNIRYPMLFKLTANETGRV 79
Query: 928 SHCGVLEFIAEEGMIYMPYWMMQNLLLQEGDIVRVRNVTLPKGTYVKLQPHTTDFLDISN 749
+H GVLEFIAEEG +Y+P WMM+ L +Q G ++++ + +P G +VKL+P + DFLDIS+
Sbjct: 80 THGGVLEFIAEEGRVYLPQWMMETLGIQPGSLLQISSTDVPLGQFVKLEPQSVDFLDISD 139
Query: 748 PKAILETALRNYSCLTTGDSIMVPYNNKKYFIDIVETKP---ANGISIIETDCEVDFAPP 578
PKA+LE LRN+S LT D I + YN K + I I+E KP + I +IETD DFAPP
Sbjct: 140 PKAVLENVLRNFSTLTVDDVIEISYNGKTFKIKILEVKPESSSKSICVIETDLVTDFAPP 199
Query: 577 LDYKEPE 557
+ Y EP+
Sbjct: 200 VGYVEPD 206
>sp|Q19584|UFD1_CAEEL Ubiquitin fusion degradation protein 1 homolog
OS=Caenorhabditis elegans GN=ufd-1 PE=1 SV=1
Length = 342
Score = 181 bits (458), Expect = 1e-044
Identities = 104/261 (39%), Positives = 143/261 (54%), Gaps = 18/261 (6%)
Frame = -1
Query: 1093 FEQSYRCYPASFIDK------PQIESGDKIIMPPSALDRLASLHIDYPMLFELRNAGIER 932
++Q++ Y F+ +I G KI++P SAL+ L +I PMLF+L N ++R
Sbjct: 21 YDQTFVVYGPVFLPNATQSKISEINYGGKILLPSSALNLLMQYNIPMPMLFKLTNMAVQR 80
Query: 931 VSHCGVLEFIAEEGMIYMPYWMMQNLLLQEGDIVRVRNVTLPKGTYVKLQPHTTDFLDIS 752
V+HCGVLEF A EG +P WMMQ L L +GD +R+ + TLPK T+ KL+P + +FL+I+
Sbjct: 81 VTHCGVLEFSAPEGQAILPLWMMQQLGLDDGDTIRIESATLPKATFAKLKPMSLEFLNIT 140
Query: 751 NPKAILETALRNYSCLTTGDSIMVPYNNKKYFIDIVETKPANGISIIETDCEVDFAPPLD 572
NPKA+LE LR Y+CLT D I Y + +V+ KPAN + IIE D +DF PP
Sbjct: 141 NPKAVLEVELRKYACLTKNDRIPTSYAGQTLEFLVVDLKPANSVCIIECDVNLDFDPPEG 200
Query: 571 YKEPERPKTAPAAAKGPA-----------KAEEVVPEPEPKFNPFTGSGRRLDGRPLSYE 425
Y E R T AK PA KA + + F G+GRRLDG+
Sbjct: 201 YVEQPRQVTPAVTAKPPAPDASAFIGAGQKAGGSGGTGQNATSVFGGAGRRLDGKKKPSS 260
Query: 424 PPPASSSSSSSSKDKQPAVAN 362
S + S+ + P VAN
Sbjct: 261 SVSLSDGTGVSTSNAAP-VAN 280
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,892,683,958
Number of Sequences: 518415
Number of Extensions: 92892683958
Number of Successful Extensions: 611291351
Number of sequences better than 0.0: 0
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