BLASTX 7.6.2
Query= UN22579 /QuerySize=1798
(1797 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9LYT3|TT12_ARATH Protein TRANSPARENT TESTA 12 OS=Arabidopsis... 359 6e-098
sp|A1L1P9|S47A1_DANRE Multidrug and toxin extrusion protein 1 OS... 199 8e-050
sp|Q3V050|S47A2_MOUSE Multidrug and toxin extrusion protein 2 OS... 187 3e-046
sp|Q96FL8|S47A1_HUMAN Multidrug and toxin extrusion protein 1 OS... 184 3e-045
sp|Q5RFD2|S47A1_PONAB Multidrug and toxin extrusion protein 1 OS... 181 2e-044
sp|A7KAU3|S47A2_RABIT Multidrug and toxin extrusion protein 2 OS... 157 4e-037
sp|Q9UT92|YL47_SCHPO Uncharacterized transporter C323.07c OS=Sch... 142 9e-033
sp|Q86VL8|S47A2_HUMAN Multidrug and toxin extrusion protein 2 OS... 107 3e-022
sp|Q73BB8|NORM_BACC1 Probable multidrug resistance protein norM ... 87 3e-016
sp|Q5R7E4|S47A2_PONAB Multidrug and toxin extrusion protein 2 OS... 82 9e-015
sp|Q7NXN3|NORM_CHRVO Probable multidrug resistance protein norM ... 74 4e-012
sp|Q81T85|NORM_BACAN Probable multidrug resistance protein norM ... 59 8e-008
sp|Q6HLG9|NORM_BACHK Probable multidrug resistance protein norM ... 59 8e-008
sp|Q81G28|NORM_BACCR Probable multidrug resistance protein norM ... 58 2e-007
sp|Q63DZ4|NORM_BACCZ Probable multidrug resistance protein norM ... 57 3e-007
>sp|Q9LYT3|TT12_ARATH Protein TRANSPARENT TESTA 12 OS=Arabidopsis thaliana
GN=TT12 PE=2 SV=1
Length = 507
Score = 359 bits (919), Expect = 6e-098
Identities = 179/443 (40%), Positives = 275/443 (62%), Gaps = 2/443 (0%)
Frame = +3
Query: 198 ESAKLWKIAAPIGFNIICQYGVTSLTNIFVGHIGEIELSAVSISLSVIGTFSFGFLLGMG 377
ES LW ++ + Y ++ +T +F GH+G ++L+ SI+ I ++G +LGM
Sbjct: 51 ESKLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVGIQGLAYGIMLGMA 110
Query: 378 SALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCIFLLPIYIFATPVLRLLGQAEEIAVA 557
SA++T+CGQA+GA Q +G+ QR+ ++ + +FL +Y ++ P+L+ +GQ+ IA
Sbjct: 111 SAVQTVCGQAYGARQYSSMGIICQRAMVLHLAAAVFLTFLYWYSGPILKTMGQSVAIAHE 170
Query: 558 AGEFTLLTIPQLFSMAFTFPTSKFLQAQSKVIAIAWIGFVALIMHVAMLWLFIVVFGWGT 737
F IPQ+++ A P +FLQAQ+ V +A++ ++H + WL V +G
Sbjct: 171 GQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTWLVTNVLDFGL 230
Query: 738 NGAALAFSITNWGTAISQIVYVI--GWCNEGWTGLTWLAFKEIWAFVRLSIASAVMLCLE 911
GAAL S + W +Y++ C E WTG + AF+ IW + +L++ASAVMLCLE
Sbjct: 231 LGAALILSFSWWLLVAVNGMYILMSPNCKETWTGFSTRAFRGIWPYFKLTVASAVMLCLE 290
Query: 912 LWYMMSIIVLTGRLDNAVIAVDSLSICMNVNGLEAMLFIGINAAISVRVSNELGLGRPRA 1091
+WY +++++G L N I++D++SICM + +G++AAISVRVSNELG G PR
Sbjct: 291 IWYNQGLVIISGLLSNPTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRV 350
Query: 1092 AKYSVYVAVLQSLLIGLVFMVAIIIARDRFAIIYTSSEVLQRAVSKLAYLLGITMVLNSV 1271
A SV V + ++LI V V +++ R + +TS + AVS L LL +++ LN +
Sbjct: 351 AMLSVVVVNITTVLISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGI 410
Query: 1272 QPVISGVAIGGGWQGLVAYINLGCYYIFGLPFGYILGYKANLGVMGLWAGMVAGTTLQTL 1451
QP++SGVAIG GWQ +VAY+NL YY+ GLP G +LG+K +LGV G+W GM+AG LQTL
Sbjct: 411 QPILSGVAIGSGWQAVVAYVNLVTYYVIGLPIGCVLGFKTSLGVAGIWWGMIAGVILQTL 470
Query: 1452 LLVVVLYKTNWNKEVEETMERMK 1520
L+V+ KTNW EVE +R+K
Sbjct: 471 TLIVLTLKTNWTSEVENAAQRVK 493
>sp|A1L1P9|S47A1_DANRE Multidrug and toxin extrusion protein 1 OS=Danio rerio
GN=slc47a1 PE=2 SV=1
Length = 590
Score = 199 bits (504), Expect = 8e-050
Identities = 123/445 (27%), Positives = 221/445 (49%), Gaps = 6/445 (1%)
Frame = +3
Query: 189 FSMESAKLWKIAAPIGFNIICQYGVTSLTNIFVGHIGEIELSAVSISLSVIGTFSFGFLL 368
+ E +L K+A P+ + + + ++ ++ +F GH+G+ EL+ V+++++VI
Sbjct: 49 YKTEIVELLKLAGPVFISQLMIFLISFVSTVFCGHLGKTELAGVALAIAVINVTGISIGS 108
Query: 369 GMGSALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCIFLLPIYIFATPVLRLLGQAEEI 548
G+ SA +TL Q FG+ + +GV +QR +IL ++C + I P+L + Q+ +
Sbjct: 109 GLASACDTLISQTFGSNNLKRVGVILQRGILILLLACFPCWALLINTEPILLAVRQSPNV 168
Query: 549 AVAAGEFTLLTIPQLFSMAFTFPTSKFLQAQSKVIAIAWIGFVALIMHVAMLWLFIVVFG 728
A + + + +P L + ++LQ Q + G I++ + ++F+ +
Sbjct: 169 ASLSQLYVKIFMPALPAAFMYQLQGRYLQNQGIIWPQVITGAAGNILNALINYVFLHLLE 228
Query: 729 WGTNGAALAFSITNWGTAISQIVYVIGWCN---EGWTGLTWLAFKEIWAFVRLSIASAVM 899
G G+A A +I+ + A+ VY I W N W G + +E AF+RL++ S +M
Sbjct: 229 LGVAGSAAANTISQYSLAVFLYVY-IRWKNLHKATWDGWSRDCLQEWGAFIRLALPSMLM 287
Query: 900 LCLELWYMMSIIVLTGRLDNAVIAVDSLSICMNVNGLEAMLFIGINAAISVRVSNELGLG 1079
LC+E W L G + + S+ + + M +G A SVRV N LG G
Sbjct: 288 LCVEWWTYEIGGFLAGLISETELGAQ--SVVYELATIAYMFPLGFAVAASVRVGNALGAG 345
Query: 1080 RPRAAKYSVYVAVLQSLLIGLVFMVAIIIARDRFAIIYTSSEVLQRAVSKLAYLLGITMV 1259
AK S VA++ +L+ V I +D A I+T+ E + VS++ + G +
Sbjct: 346 NTERAKLSAKVALVCGVLVSCVVATLIGCTKDVIAYIFTTEEEIVSRVSQVMIMYGFFHL 405
Query: 1260 LNSVQPVISGVAIGGGWQGLVAYINLGCYYIFGLPFGYILGYKANLGVMGLWAGMVAGTT 1439
+++ + G+ G G Q L A N+ YY G P G L + ++G++GLW G
Sbjct: 406 FDAIAGITGGIVRGAGKQLLGALCNIVGYYFVGFPTGVSLMFALSMGIIGLWIGFFGCVF 465
Query: 1440 LQTLLLVVVLYKTNWNKEVEETMER 1514
LQ+L ++++YK +W K +E + R
Sbjct: 466 LQSLFFIILIYKLDWKKATQEALIR 490
>sp|Q3V050|S47A2_MOUSE Multidrug and toxin extrusion protein 2 OS=Mus musculus
GN=Slc47a2 PE=1 SV=1
Length = 573
Score = 187 bits (473), Expect = 3e-046
Identities = 125/452 (27%), Positives = 229/452 (50%), Gaps = 14/452 (3%)
Frame = +3
Query: 174 DVKRVFSMESAKLWKIAAPIGFNIICQYGVTSLTNIFVGHIGEIELSAVSISLSVIGTFS 353
DV+R E+A L +A P+ + + ++ +++IF GH+G++EL AV++++SV+
Sbjct: 39 DVRR----EAAALVALAGPVFLAQLMIFLISIVSSIFCGHLGKVELDAVTLAVSVVNVTG 94
Query: 354 FGFLLGMGSALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCIFLLPIYIFATPVLRLLG 533
G+ SA +TL Q+FG + +GV +QR +IL + C I++ +L LL
Sbjct: 95 ISVGTGLASACDTLMSQSFGGKNLKRVGVILQRGILILLLCCFPCWAIFLNTERLLLLLR 154
Query: 534 QAEEIAVAAGEFTLLTIPQLFSMAFTFP-TSKFLQAQSKVIAIAWIGFVALIMHVAMLWL 710
Q ++A A + ++ IP L AF F +++LQ+Q ++ +G A +++V M
Sbjct: 155 QDPDVARLAQVYVMICIPAL-PAAFLFQLQTRYLQSQGIIMPQVIVGIAANVVNVGMNAF 213
Query: 711 FIVVFGWGTNGAALAFSITNWGTAISQIVYVIGWCN----EGWTGLTWLAFKEIWAFVRL 878
+ G G+A A + + + +S ++++ W W G T F+E ++ RL
Sbjct: 214 LLYALDLGVVGSAWANTTSQF--FLSALLFLYVWWKRIHIHTWGGWTRECFQEWSSYTRL 271
Query: 879 SIASAVMLCLELWYMMSIIVLTGRLDNAVIAVDSLSICMNVNGLEAMLFIGINAAISVRV 1058
+I S M+C+E W L G ++ V + + ++ + + M+ G A SVRV
Sbjct: 272 AIPSMFMVCIEWWTFEIGTFLAGLVN--VTELGAQAVIYELASVAYMVPFGFGVAASVRV 329
Query: 1059 SNELGLGRPRAAKYSVYVAVLQSLLIGLVFMVAIIIARDRFAIIYTSSEVLQRAVSKLAY 1238
N LG G A+ S +L + + L+ + + +D A I+T+ + + VS++
Sbjct: 330 GNALGAGNADQARCSCTTVLLCAGVCALLVGILLAALKDVVAYIFTNDKDIISLVSQVMP 389
Query: 1239 LLGITMVLNSVQPVISGVAIGGGWQGLVAYINLGCYYIFGLPFGYILGYKANLGVMGLWA 1418
+ + +++ GV G G Q + A +N YY FG P G L + A LG++GLWA
Sbjct: 390 IFAPFHLFDALAGTCGGVLRGTGKQKIGAVLNTIGYYGFGFPIGVSLMFAAKLGIIGLWA 449
Query: 1419 GMVAGTTLQTLLLVVVLYKTNWNKEVEETMER 1514
G++ + Q ++ + +TNW++ E+ R
Sbjct: 450 GLIVCVSFQAFSYLIYILRTNWSRVAEQAQVR 481
>sp|Q96FL8|S47A1_HUMAN Multidrug and toxin extrusion protein 1 OS=Homo sapiens
GN=SLC47A1 PE=1 SV=1
Length = 570
Score = 184 bits (465), Expect = 3e-045
Identities = 123/461 (26%), Positives = 227/461 (49%), Gaps = 6/461 (1%)
Frame = +3
Query: 126 GGGEVREDYSPARTLSDVKRVFSMESAKLWKIAAPIGFNIICQYGVTSLTNIFVGHIGEI 305
GG E + +R L F E L +A P + + ++ ++++F GH+G++
Sbjct: 12 GGPEATLEVRGSRCLR--LSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKL 69
Query: 306 ELSAVSISLSVIGTFSFGFLLGMGSALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCIF 485
EL AV+++++VI G+ SA +TL Q +G+ + +GV +QRS ++L + C
Sbjct: 70 ELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFP 129
Query: 486 LLPIYIFATPVLRLLGQAEEIAVAAGEFTLLTIPQLFSMAFTFPTSKFLQAQSKVIAIAW 665
+++ +L L Q +++ + + IP L + K+L Q V+
Sbjct: 130 CWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIV 189
Query: 666 IGFVALIMHVAMLWLFIVVFGWGTNGAALAFSITNWGTAISQIVYVIG--WCNEGWTGLT 839
G A +++ +LF+ G G+ALA I+ + A+ +Y++G W G +
Sbjct: 190 TGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWS 249
Query: 840 WLAFKEIWAFVRLSIASAVMLCLELWYMMSIIVLTGRLDNAVIAVDSLSICMNVNGLEAM 1019
++ +F+RL+I S +MLC+E W L+G L ++ + + SI + + M
Sbjct: 250 LECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGIL--GMVELGAQSIVYELAIIVYM 307
Query: 1020 LFIGINAAISVRVSNELGLGRPRAAKYSVYVAVLQSLLIGLVFMVAIIIARDRFAIIYTS 1199
+ G + A SVRV N LG G A+ S V++L ++L + F V ++ +D I+T+
Sbjct: 308 VPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTT 367
Query: 1200 SEVLQRAVSKLAYLLGITMVLNSVQPVISGVAIGGGWQGLVAYINLGCYYIFGLPFGYIL 1379
+ V+++ + ++ + ++ GV G G Q + A +N YY+ GLP G L
Sbjct: 368 DRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIAL 427
Query: 1380 GYKANLGVMGLWAGMVAGTTLQTLLLVVVLYKTNWNKEVEE 1502
+ LGVMGLW+G++ T Q + + + + NW K ++
Sbjct: 428 MFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQ 468
>sp|Q5RFD2|S47A1_PONAB Multidrug and toxin extrusion protein 1 OS=Pongo abelii
GN=SLC47A1 PE=2 SV=1
Length = 570
Score = 181 bits (457), Expect = 2e-044
Identities = 117/440 (26%), Positives = 218/440 (49%), Gaps = 4/440 (0%)
Frame = +3
Query: 189 FSMESAKLWKIAAPIGFNIICQYGVTSLTNIFVGHIGEIELSAVSISLSVIGTFSFGFLL 368
F E L +A P + + ++ ++++F GH+G++EL AV+++++VI
Sbjct: 31 FREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGF 90
Query: 369 GMGSALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCIFLLPIYIFATPVLRLLGQAEEI 548
G+ SA +TL Q +G+ + +GV +QRS +IL + C +++ +L L Q ++
Sbjct: 91 GLSSACDTLISQTYGSQNLKHVGVILQRSALILLLCCFPCWALFLNTQHILLLFRQDPDV 150
Query: 549 AVAAGEFTLLTIPQLFSMAFTFPTSKFLQAQSKVIAIAWIGFVALIMHVAMLWLFIVVFG 728
+ + + IP L + K+L Q V+ G A +++ +LF+
Sbjct: 151 SRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLH 210
Query: 729 WGTNGAALAFSITNWGTAISQIVYVIG--WCNEGWTGLTWLAFKEIWAFVRLSIASAVML 902
G G+ALA I+ + A+ Y++G W G + ++ +F+ L++ S +ML
Sbjct: 211 LGAIGSALANLISQYTLALLLFFYILGKKLHQATWGGWSLECLQDWASFLHLAVPSMLML 270
Query: 903 CLELWYMMSIIVLTGRLDNAVIAVDSLSICMNVNGLEAMLFIGINAAISVRVSNELGLGR 1082
C+E W L+G L ++ + + SI + + M+ G + A SVRV N LG G
Sbjct: 271 CMEWWAYEVGSFLSGIL--GMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGD 328
Query: 1083 PRAAKYSVYVAVLQSLLIGLVFMVAIIIARDRFAIIYTSSEVLQRAVSKLAYLLGITMVL 1262
A+ S V++L ++L + F V ++ +D I+T+ + V+++ + ++ +
Sbjct: 329 MEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLF 388
Query: 1263 NSVQPVISGVAIGGGWQGLVAYINLGCYYIFGLPFGYILGYKANLGVMGLWAGMVAGTTL 1442
++ GV G G Q + A +N YY+ GLP G L + LGVMGLW+G++ T
Sbjct: 389 EALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATKLGVMGLWSGIIICTVF 448
Query: 1443 QTLLLVVVLYKTNWNKEVEE 1502
Q + + + + NW K ++
Sbjct: 449 QAVCFLGFIIQLNWKKACQQ 468
>sp|A7KAU3|S47A2_RABIT Multidrug and toxin extrusion protein 2 OS=Oryctolagus
cuniculus GN=SLC47A2 PE=1 SV=1
Length = 601
Score = 157 bits (395), Expect = 4e-037
Identities = 112/445 (25%), Positives = 207/445 (46%), Gaps = 4/445 (0%)
Frame = +3
Query: 183 RVFSMESAKLWKIAAPIGFNIICQYGVTSLTNIFVGHIGEIELSAVSISLSVIGTFSFGF 362
R F E+ L+ ++ P+ + + + +F GH+G++EL++V++ ++ +
Sbjct: 54 RGFWDEARALFVLSGPLFLFQVLNFLTYVVGTVFCGHLGKVELASVTLGVAFVNVCGVSV 113
Query: 363 LLGMGSALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCIFLLPIYIFATPVLRLLGQAE 542
G+ SA +TL Q+FG+ +GV +QR +IL + C+ +++ +L L Q
Sbjct: 114 GAGLSSACDTLMSQSFGSPNKKHVGVILQRGSLILLLCCLPCWALFLNTQHILLLFRQDP 173
Query: 543 EIAVAAGEFTLLTIPQLFSMAFTFPTSKFLQAQSKVIAIAWIGFVALIMHVAMLWLFIVV 722
++ ++ ++ IP L ++ +K+LQ Q V G V ++ + + V
Sbjct: 174 AVSRLTQDYAMIFIPGLPAIFLYSLLAKYLQNQGIVWPQVLSGVVGNCVNGVANYALVSV 233
Query: 723 FGWGTNGAALAFSITNWGTAISQIVYVI--GWCNEGWTGLTWLAFKEIWAFVRLSIASAV 896
G G+A A +I+ + A ++++ E W G + ++ F+ L+I S +
Sbjct: 234 LNLGVRGSAYANTISQFVQAAFLFLHIVLKKLHLETWEGWSSQCLRDWGPFLSLAIPSML 293
Query: 897 MLCLELWYMMSIIVLTGRLDNAVIAVDSLSICMNVNGLEAMLFIGINAAISVRVSNELGL 1076
M+C+E W L G L V+ + +I V + M+ +G+ A+ VRV LG
Sbjct: 294 MMCVEWWAYEIGSFLMGLL--GVVDLSGQAIIYEVATVVYMIPMGLGMAVCVRVGTALGA 351
Query: 1077 GRPRAAKYSVYVAVLQSLLIGLVFMVAIIIARDRFAIIYTSSEVLQRAVSKLAYLLGITM 1256
AK S +L + LV + + + I+TS E + V+++ + +
Sbjct: 352 ADTLQAKRSAVSGLLCTAGTSLVVGTLLGLLNSQLGYIFTSDEEVIALVNQVLPIYIVFQ 411
Query: 1257 VLNSVQPVISGVAIGGGWQGLVAYINLGCYYIFGLPFGYILGYKANLGVMGLWAGMVAGT 1436
++ +V V GV G G Q A +N YYI GLP G +L + + +MGLW GM+
Sbjct: 412 LVEAVCCVFGGVLRGTGKQAFGAIVNAIMYYIVGLPLGIVLTFVVGMRIMGLWLGMLTCI 471
Query: 1437 TLQTLLLVVVLYKTNWNKEVEETME 1511
L + VV + +W EE +
Sbjct: 472 FLAAVTFVVYAVQLDWKLAAEEAQK 496
>sp|Q9UT92|YL47_SCHPO Uncharacterized transporter C323.07c
OS=Schizosaccharomyces pombe GN=SPAC323.07c PE=1 SV=1
Length = 533
Score = 142 bits (357), Expect = 9e-033
Identities = 116/448 (25%), Positives = 201/448 (44%), Gaps = 7/448 (1%)
Frame = +3
Query: 186 VFSMESAKLWKIAAPIGFNIICQYGVTSLTNIFVGHIGEIELSAVSISLSVIGTFSFGFL 365
V E ++L ++ +P + Q T +GH+G+ L+A S+S +F
Sbjct: 86 VIKHELSELLRLGSPTVIAYLLQSSEQFSTVFTLGHLGKEYLAASSLSTMTAAISAFSIF 145
Query: 366 LGMGSALETLCGQAFGAGQVHMLGVYMQRSWIILFVSCIFLLPIYIFATPVLRLLGQAEE 545
G+ S+L+TL QAFGA + + + +Y+QR +IL V I + I++ +L L Q
Sbjct: 146 QGVISSLDTLATQAFGANKPYNVAIYLQRCLLILAVLHIPVALIWLNLEHILIFLHQDPM 205
Query: 546 IAVAAGEFTLLTIPQLFSMAFTFPTSKFLQAQSKVIAIAWIGFVALIMHVAMLWLFI--V 719
+A G + + I A ++LQAQ I ++ A +++ + +L +
Sbjct: 206 VAHLCGRYMRVFILAAPGYAVFEALKRYLQAQGIFTPITYVLCFAAPLNILLNYLLVWHP 265
Query: 720 VFGWGTNGAALAFSITNWGTAISQIVYV-IGWCNEGWTGLTWLAFKEIWAFVRLSIASAV 896
G+G GA +A + T W +I I+Y+ W G + A K + + S +
Sbjct: 266 TIGFGFLGAPVAVATTFWFQSICLILYICFSSTPIPWPGFSRQALKNLSPMLHFSFHGML 325
Query: 897 MLCLELWYMMSIIVL-TGRLDNAVIAVDSLSICMNVNGLEAMLFIGINAAISVRVSNELG 1073
M+ E W + L G L A +A S SI + L + A S RV + +G
Sbjct: 326 MIVTE-WAAYEMTSLGAGYLGTAPLA--SQSILLTSTSLLFQIPFAFAVASSTRVGHLIG 382
Query: 1074 LGRPRAAKYSVYVAVLQSLLIGLVFMVAIIIARDRFAIIYTSSEVLQRAVSKLAYLLGIT 1253
GR A+ VA +L I + I RD + ++TS + V + +L +
Sbjct: 383 SGRANLARLCSRVAYSLALCISIFDGSLIFCFRDVWGSLFTSDPEVLAVVKDIFPILSLF 442
Query: 1254 MVLNSVQPVISGVAIGGGWQGLVAYINLGCYYIFGLPFGYILGYKANLGVMGLWAGMVAG 1433
+V + + V G+ G G Q + I++G Y+F LP + N G+ G+W GM+
Sbjct: 443 IVTDGLNAVGGGLLRGTGKQYIGGLISIGSSYLFALPVTVFVVVYFNTGLKGIWCGMILS 502
Query: 1434 TTLQTLLLVVVLYKTNWNKEVEETMERM 1517
+ VL+ T+W++ ++E R+
Sbjct: 503 SVTAITCQFTVLFNTDWHRVLQEARHRL 530
>sp|Q86VL8|S47A2_HUMAN Multidrug and toxin extrusion protein 2 OS=Homo sapiens
GN=SLC47A2 PE=1 SV=1
Length = 602
Score = 107 bits (266), Expect = 3e-022
Identities = 74/268 (27%), Positives = 125/268 (46%), Gaps = 4/268 (1%)
Frame = +3
Query: 705 WLFIVVFGWGTNGAALAFSITNWGTAISQIVYVI--GWCNEGWTGLTWLAFKEIWAFVRL 878
+ + V G G+A A I+ + + ++Y++ E W G + ++ F L
Sbjct: 235 YALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSL 294
Query: 879 SIASAVMLCLELWYMMSIIVLTGRLDNAVIAVDSLSICMNVNGLEAMLFIGINAAISVRV 1058
++ S +M+C+E W L G L +V+ + + ++ V + M+ +G++ + VRV
Sbjct: 295 AVPSMLMICVEWWAYEIGSFLMGLL--SVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRV 352
Query: 1059 SNELGLGRPRAAKYSVYVAVLQSLLIGLVFMVAIIIARDRFAIIYTSSEVLQRAVSKLAY 1238
LG AK S VL + I LV I I +++ I+T+ E + VS++
Sbjct: 353 GMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLP 412
Query: 1239 LLGITMVLNSVQPVISGVAIGGGWQGLVAYINLGCYYIFGLPFGYILGYKANLGVMGLWA 1418
+ + V ++ V GV G G Q A +N YYI GLP G +L + + +MGLW
Sbjct: 413 VYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWL 472
Query: 1419 GMVAGTTLQTLLLVVVLYKTNWNKEVEE 1502
GM+A L T V + +W EE
Sbjct: 473 GMLACVFLATAAFVAYTARLDWKLAAEE 500
>sp|Q73BB8|NORM_BACC1 Probable multidrug resistance protein norM OS=Bacillus
cereus (strain ATCC 10987) GN=norM PE=3 SV=1
Length = 454
Score = 87 bits (215), Expect = 3e-016
Identities = 93/458 (20%), Positives = 188/458 (41%), Gaps = 26/458 (5%)
Frame = +3
Query: 189 FSMESAKLWKIAAPIGFNIICQYGVTSLTNIFVGHIGEIELSAVSISLSVIGTFSFGFLL 368
FS + + + PI + + ++ GH I+L+ V+I S+ S G L
Sbjct: 7 FSQKLKQFVLLFFPIFITQMSLFAMSFFDTTMSGHASPIDLAGVAIGTSIWIPVSTG-LT 65
Query: 369 GMGSALETLCGQAFGAGQVH-MLGVYMQRSWIILFVSCIFLLPIYIFATPVLRLLGQAEE 545
G+ A + Q G+ + + V +Q ++ + S + +L + TP+L + E
Sbjct: 66 GILMATTPIVAQLVGSKKKEDVPQVVIQAVYLAICASFVVMLIGFFAVTPILNGMRLEEP 125
Query: 546 IAVAAGEFTLLTIPQLFSMAFTFPTSK-FLQAQSKVIAIAWIGFVALIMHVAMLWLFIVV 722
+ A +F + + + FT+ + F+ A K I ++L ++V + ++++
Sbjct: 126 VERIAAQFLSIIAIGIIPL-FTYTVLRGFIDALGKTRTTMIITLLSLPINVIL--NYVLI 182
Query: 723 FG------WGTNGAALAFSITNWGTAISQIVYVIGWCNEGWTGLTWLAFKEIW------- 863
FG G GAA+A + T W I I +I E + ++ FK+++
Sbjct: 183 FGHFGFPKLGGVGAAIASTATYW--CILIITVMIIRTKEPFA--SFHIFKQLYRPSLSSW 238
Query: 864 -AFVRLSIASAVMLCLELWYMMSIIVLTGRLDNAVIAVDSLSICMNVNGLEAMLFIGINA 1040
F++L + + E ++ ++ IA + MN L M + +
Sbjct: 239 KEFLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAA--MNFASLLYMTPLSLAM 296
Query: 1041 AISVRVSNELGLGRPRAAKYSVYVAVLQSLLIGLVFMVAIIIARDRFAIIYTSSEVLQRA 1220
A+++ V E+G R AK ++ + +L L++ + + D A IYT+ +
Sbjct: 297 AMTIAVGFEVGAKRYNNAKQYGFIGIGLALAFALLYSILLYFFDDEIASIYTTDIQVHHL 356
Query: 1221 VSKLAYLLGITMVLNSVQPVISGVAIGGGWQGLVAYINLGCYYIFGLPFGYILGYKANLG 1400
+ + + +++ + G G + + L Y++ GLP GYIL +
Sbjct: 357 AKEFLIFAILFQISDAIATPVQGALRGYKDVNVSLIMTLIAYWVIGLPLGYILATYTDWA 416
Query: 1401 VMGLWAGMVAGTTLQTLLLVVVLYKTNWNKEVEETMER 1514
G W G++ G L++ L++ +E R
Sbjct: 417 AKGYWIGLIIGLAFGATFLLIRLFQVQRKYTIENRRSR 454
>sp|Q5R7E4|S47A2_PONAB Multidrug and toxin extrusion protein 2 OS=Pongo abelii
GN=SLC47A2 PE=2 SV=1
Length = 581
Score = 82 bits (202), Expect = 9e-015
Identities = 55/175 (31%), Positives = 82/175 (46%), Gaps = 4/175 (2%)
Frame = +3
Query: 1014 AMLFIGINAAISVRVSNELGLGRPRAAKYSVYVAVLQSLLIGLVFMVAIIIARDRFAIIY 1193
A + +G++ + VRV LG AK S VL + I LV I I +++ I+
Sbjct: 316 ARIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIF 375
Query: 1194 TSSEVLQRAVSKLAYLLGITMVLNSVQPVISGVAIGGGWQGLVAYINLGCYYIFGLPFGY 1373
T+ E + VS++ + + V ++ V GV G G Q A +N YYI GLP G
Sbjct: 376 TNDEDVIALVSQVLPVYSVFHVFEAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGI 435
Query: 1374 ILGYKANLGVMGLWAGMVAGTTLQTLLLVVVLYKTNWNKEVEETMERMKKWGGSE 1538
+L + + +MGLW GM+A L T V + +W EE KK G +
Sbjct: 436 LLTFVVRMRIMGLWLGMLACVFLATAAFVAYTARLDWKLAAEEA----KKHSGQQ 486
>sp|Q7NXN3|NORM_CHRVO Probable multidrug resistance protein norM
OS=Chromobacterium violaceum GN=norM PE=3 SV=1
Length = 465
Score = 74 bits (179), Expect = 4e-012
Identities = 66/289 (22%), Positives = 125/289 (43%), Gaps = 16/289 (5%)
Frame = +3
Query: 654 AIAWIGFVALIMHVAMLWLFI-VVFG---WGTNGAALAFSITNWGTAISQIVYVIGW--- 812
AI + +AL +++ + ++ I +FG G G A I W ++ + YV W
Sbjct: 168 AIMVVSLLALALNIPLNYILIHGLFGMPRMGGAGCGWATGIVFWFNCLALLTYV-SWHRH 226
Query: 813 --CNEGWTGLTWLAFKEIWAFVRLSIASAVMLCLELWYMMSIIVLTGRLDNAVIAVDSLS 986
+ GL ++ AF++L + + +E+ I +L L V+A
Sbjct: 227 FRDSRILAGLAAPDWRRFLAFLKLGVPIGLSFFVEVSLFSFIALLIAELGTVVVATH--Q 284
Query: 987 ICMNVNGLEAMLFIGINAAISVRVSNELGLGRPRAAKYSVYVAVLQSLLIGLVFMVAIII 1166
+N + L ML + A+SVRV + G G RAA++ V +L L + M +++
Sbjct: 285 SVLNFSSLIYMLPQSVATALSVRVGHHAGAGDYRAARFISGVGMLMGLAMAGGAMALVLL 344
Query: 1167 ARDRFAIIYTSSEVLQRAVSKLAYLLGITMVLNSVQPVISGVAIGGGWQGLVAYINLGCY 1346
R+ +Y++ + + L + + ++ Q + SG G + I++ +
Sbjct: 345 LREPIMWMYSADPRVIAMGTTLLLFAAVYQLTDAAQTIASGALRGYKLTAVPMLIHITSF 404
Query: 1347 YIFGLPFGYILGYK----ANLGVMGLWAGMVAGTTLQTLLLVVVLYKTN 1481
++ GL G +LG +G+ G W +V T+ LLL L + +
Sbjct: 405 WVAGLGLGMLLGLTDWIVPRMGIYGFWTALVISLTVAGLLLTYYLARAS 453
>sp|Q81T85|NORM_BACAN Probable multidrug resistance protein norM OS=Bacillus
anthracis GN=norM PE=3 SV=1
Length = 453
Score = 59 bits (142), Expect = 8e-008
Identities = 35/161 (21%), Positives = 69/161 (42%)
Frame = +3
Query: 993 MNVNGLEAMLFIGINAAISVRVSNELGLGRPRAAKYSVYVAVLQSLLIGLVFMVAIIIAR 1172
MN L M + + A+++ V E+G R AK ++ + +L L++ + +
Sbjct: 281 MNFASLLYMTPLSLAMAMTIAVGFEVGAKRYNNAKQYGFIGIGLALAFALLYSILLYFFD 340
Query: 1173 DRFAIIYTSSEVLQRAVSKLAYLLGITMVLNSVQPVISGVAIGGGWQGLVAYINLGCYYI 1352
D A IYT+ + + + + +++ + G G + + L Y++
Sbjct: 341 DEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWV 400
Query: 1353 FGLPFGYILGYKANLGVMGLWAGMVAGTTLQTLLLVVVLYK 1475
GLP GYIL + G W G++ G L++ L++
Sbjct: 401 IGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQ 441
>sp|Q6HLG9|NORM_BACHK Probable multidrug resistance protein norM OS=Bacillus
thuringiensis subsp. konkukian GN=norM PE=3 SV=1
Length = 453
Score = 59 bits (142), Expect = 8e-008
Identities = 35/161 (21%), Positives = 69/161 (42%)
Frame = +3
Query: 993 MNVNGLEAMLFIGINAAISVRVSNELGLGRPRAAKYSVYVAVLQSLLIGLVFMVAIIIAR 1172
MN L M + + A+++ V E+G R AK ++ + +L L++ + +
Sbjct: 281 MNFASLLYMTPLSLAMAMTIAVGFEVGAKRYNNAKQYGFIGIGLALAFALLYSILLYFFD 340
Query: 1173 DRFAIIYTSSEVLQRAVSKLAYLLGITMVLNSVQPVISGVAIGGGWQGLVAYINLGCYYI 1352
D A IYT+ + + + + +++ + G G + + L Y++
Sbjct: 341 DEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWV 400
Query: 1353 FGLPFGYILGYKANLGVMGLWAGMVAGTTLQTLLLVVVLYK 1475
GLP GYIL + G W G++ G L++ L++
Sbjct: 401 IGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQ 441
>sp|Q81G28|NORM_BACCR Probable multidrug resistance protein norM OS=Bacillus
cereus (strain ATCC 14579 / DSM 31) GN=norM PE=3 SV=1
Length = 452
Score = 58 bits (139), Expect = 2e-007
Identities = 36/161 (22%), Positives = 68/161 (42%)
Frame = +3
Query: 993 MNVNGLEAMLFIGINAAISVRVSNELGLGRPRAAKYSVYVAVLQSLLIGLVFMVAIIIAR 1172
MN L M + + A+++ V E+G R AK + + +L L++ + +
Sbjct: 281 MNFASLLYMTPLSLAMAMTIAVGFEVGAKRYDNAKQYGLIGIGLALAFALLYSILLYFFD 340
Query: 1173 DRFAIIYTSSEVLQRAVSKLAYLLGITMVLNSVQPVISGVAIGGGWQGLVAYINLGCYYI 1352
D+ A IYT+ + + + + +++ + G G + + L Y+I
Sbjct: 341 DQIASIYTTDAKVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWI 400
Query: 1353 FGLPFGYILGYKANLGVMGLWAGMVAGTTLQTLLLVVVLYK 1475
GLP GYIL G W G++ G L++ L++
Sbjct: 401 IGLPLGYILATYTEWAAKGYWIGLIIGLAFGAAFLLIRLFQ 441
>sp|Q63DZ4|NORM_BACCZ Probable multidrug resistance protein norM OS=Bacillus
cereus (strain ZK / E33L) GN=norM PE=3 SV=1
Length = 453
Score = 57 bits (137), Expect = 3e-007
Identities = 34/161 (21%), Positives = 69/161 (42%)
Frame = +3
Query: 993 MNVNGLEAMLFIGINAAISVRVSNELGLGRPRAAKYSVYVAVLQSLLIGLVFMVAIIIAR 1172
MN L M + + A+++ V E+G R AK ++ + +L L++ + +
Sbjct: 281 MNFASLLYMTPLSLAMAMTIAVGFEVGAKRYNNAKQYGFIGIGLALAFALLYSILLYFFD 340
Query: 1173 DRFAIIYTSSEVLQRAVSKLAYLLGITMVLNSVQPVISGVAIGGGWQGLVAYINLGCYYI 1352
+ A IYT+ + + + + +++ + G G + + L Y++
Sbjct: 341 NEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWV 400
Query: 1353 FGLPFGYILGYKANLGVMGLWAGMVAGTTLQTLLLVVVLYK 1475
GLP GYIL + G W G++ G L++ L++
Sbjct: 401 IGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQ 441
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,892,683,958
Number of Sequences: 518415
Number of Extensions: 92892683958
Number of Successful Extensions: 611291351
Number of sequences better than 0.0: 0
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