BLASTX 7.6.2
Query= UN22669 /QuerySize=2034
(2033 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P25870|CLH_DICDI Clathrin heavy chain OS=Dictyostelium discoi... 624 9e-178
sp|P49951|CLH1_BOVIN Clathrin heavy chain 1 OS=Bos taurus GN=CLT... 597 9e-170
sp|Q68FD5|CLH_MOUSE Clathrin heavy chain 1 OS=Mus musculus GN=Cl... 597 9e-170
sp|Q00610|CLH1_HUMAN Clathrin heavy chain 1 OS=Homo sapiens GN=C... 597 2e-169
sp|P29742|CLH_DROME Clathrin heavy chain OS=Drosophila melanogas... 597 2e-169
sp|P11442|CLH_RAT Clathrin heavy chain 1 OS=Rattus norvegicus GN... 595 6e-169
sp|P53675|CLH2_HUMAN Clathrin heavy chain 2 OS=Homo sapiens GN=C... 577 1e-163
sp|P34574|CLH_CAEEL Probable clathrin heavy chain 1 OS=Caenorhab... 573 2e-162
sp|Q10161|CLH_SCHPO Probable clathrin heavy chain OS=Schizosacch... 518 6e-146
sp|P22137|CLH_YEAST Clathrin heavy chain OS=Saccharomyces cerevi... 478 1e-133
sp|Q0IHV1|INF2_XENTR Inverted formin-2 OS=Xenopus tropicalis GN=... 54 5e-006
>sp|P25870|CLH_DICDI Clathrin heavy chain OS=Dictyostelium discoideum GN=chcA
PE=1 SV=1
Length = 1694
Score = 624 bits (1608), Expect = 9e-178
Identities = 288/516 (55%), Positives = 404/516 (78%), Gaps = 1/516 (0%)
Frame = +2
Query: 5 DAIESFIRADDATHFLEVIRAAEDTNVYDDLVRYLLMVRQKVKEPKVDSELIYAYAKIER 184
+ IESFI+A+D H+ EV+ AAE + Y+DLV++L M R+K+KEP ++SELI+AYAK+ +
Sbjct: 1124 ECIESFIKANDTEHYQEVVAAAERKDEYEDLVKFLQMCRKKIKEPAIESELIFAYAKVNK 1183
Query: 185 LGEIEEFILMPNVANLPNVGDRLYDEALYEAAKIIYAFTSNWAKLAVTLVKLQQFQSAVD 364
L E+E+FI PN A++ VGDR ++ LYEAAK++Y SN+++L LVKL Q+Q+AVD
Sbjct: 1184 LAEMEDFINSPNSAHIQVVGDRCFENGLYEAAKVLYTNISNFSRLTSCLVKLGQYQAAVD 1243
Query: 365 AARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSEYYQNRGCFNELISL 544
AARKANS KTWKEV AC+DA+EFRLAQ+CG+NII+ D+LEE+ Y++RG FNELISL
Sbjct: 1244 AARKANSTKTWKEVSAACIDAKEFRLAQVCGINIIVHGDELEELIRQYEDRGYFNELISL 1303
Query: 545 MESGLGLERALMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACDEQQHWQELT 724
+ESGL ERA +G+FTEL +LY++Y+ EKLMEH+KLF +RLN+PK+I+AC Q W +LT
Sbjct: 1304 LESGLASERAHVGMFTELAILYSKYKEEKLMEHLKLFYSRLNVPKVIKACQANQQWPQLT 1363
Query: 725 YLYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDIINDL 904
YLYI YDE DNA T++NHS EAW+H+ FK+ + KVA ++LYY A+ FYL+E P +INDL
Sbjct: 1364 YLYIHYDEHDNAIQTMINHSIEAWDHVLFKETIPKVAKLDLYYSAISFYLEEQPLLINDL 1423
Query: 905 LNVLALRLDHTRVVDIMRKAGQLRLIKPYMVAVQSNNVSAVNEALNEIYVEEEDYDRLRE 1084
L+VL+ R+DHTR V ++R G L L+KPY+V+ Q NV+A+NEALNE+YVEEEDY+ LR
Sbjct: 1424 LSVLSPRIDHTRAVTLIRSLGHLPLVKPYLVSAQDQNVAALNEALNELYVEEEDYESLRS 1483
Query: 1085 STDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETAS 1264
S D + +F I LAQK+EKHEL+E RR+AAY+YKK RW QS+ LSKKD +YKD +++AS
Sbjct: 1484 SIDANSNFGTIALAQKLEKHELLEFRRIAAYLYKKNNRWAQSVELSKKDKLYKDAIQSAS 1543
Query: 1265 QSGDHDLAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMIDFAFPYLLQF 1444
S + + E+LL YF++Q FA CL+ CYD ++PD +ELAW NN+++++FPYL+Q+
Sbjct: 1544 DSKNPAIGEELLQYFVDQQNNSAFAACLYTCYDFLKPDAVIELAWRNNILNYSFPYLIQY 1603
Query: 1445 IREYSGKVDELIKDKIEAQKEVKAKEQEEKDVMSQQ 1552
++EY+ KVD+L+ D +A+++ +E+E++++ S Q
Sbjct: 1604 VKEYTTKVDQLV-DDFKARQKKTEEEKEQQNIESSQ 1638
>sp|P49951|CLH1_BOVIN Clathrin heavy chain 1 OS=Bos taurus GN=CLTC PE=1 SV=1
Length = 1675
Score = 597 bits (1539), Expect = 9e-170
Identities = 286/553 (51%), Positives = 409/553 (73%), Gaps = 9/553 (1%)
Frame = +2
Query: 5 DAIESFIRADDATHFLEVIRAAEDTNVYDDLVRYLLMVRQKVKEPKVDSELIYAYAKIER 184
+AI+S+I+ADD + ++EV++AA + +++LV+YL M R+K +E V++ELI+A AK R
Sbjct: 1123 EAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNR 1182
Query: 185 LGEIEEFILMPNVANLPNVGDRLYDEALYEAAKIIYAFTSNWAKLAVTLVKLQQFQSAVD 364
L E+EEFI PN A++ VGDR YDE +Y+AAK++Y SN+ +LA TLV L ++Q+AVD
Sbjct: 1183 LAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVD 1242
Query: 365 AARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSEYYQNRGCFNELISL 544
ARKANS +TWKEVCFACVD +EFRLAQ+CGL+I++ D+LEE+ YYQ+RG F ELI++
Sbjct: 1243 GARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITM 1302
Query: 545 MESGLGLERALMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACDEQQHWQELT 724
+E+ LGLERA MG+FTEL +LY++++ +K+ EH++LF +R+NIPK++RA ++ W EL
Sbjct: 1303 LEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELV 1362
Query: 725 YLYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDIINDL 904
+LY +Y+E+DNA T+MNH +AW+ QFKDI+ KVANVELYY+A+ FYL+ P ++NDL
Sbjct: 1363 FLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDL 1422
Query: 905 LNVLALRLDHTRVVDIMRKAGQLRLIKPYMVAVQSNNVSAVNEALNEIYVEEEDYDRLRE 1084
L VL+ RLDHTR V+ K QL L+KPY+ +VQ++N +VNE+LN +++ EEDY LR
Sbjct: 1423 LMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRT 1482
Query: 1085 STDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETAS 1264
S D +D+FD I LAQ++EKHEL+E RR+AAY++K RWKQS+ L KKD++YKD M+ AS
Sbjct: 1483 SIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYAS 1542
Query: 1265 QSGDHDLAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMIDFAFPYLLQF 1444
+S D +LAE+LL +F+++ K+ECF CLF CYDL+RPDV LE AW +N++DFA PY +Q
Sbjct: 1543 ESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQV 1602
Query: 1445 IREYSGKVDELIKDKIEAQKEVKAKEQEEKDVMSQQNMYAQLLPLALPA---PPMPGMGG 1615
++EY KV DK++A + ++ +E++ + QL+ A P+ PP G
Sbjct: 1603 MKEYLTKV-----DKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGY 1657
Query: 1616 GPGMGGGYGPPPP 1654
G YG P P
Sbjct: 1658 G-YTAPAYGQPQP 1669
>sp|Q68FD5|CLH_MOUSE Clathrin heavy chain 1 OS=Mus musculus GN=Cltc PE=1 SV=3
Length = 1675
Score = 597 bits (1539), Expect = 9e-170
Identities = 287/553 (51%), Positives = 409/553 (73%), Gaps = 9/553 (1%)
Frame = +2
Query: 5 DAIESFIRADDATHFLEVIRAAEDTNVYDDLVRYLLMVRQKVKEPKVDSELIYAYAKIER 184
+AI+S+I+ADD + ++EV++AA + +++LV+YL M R+K +E V++ELI+A AK R
Sbjct: 1123 EAIDSYIKADDPSSYMEVVQAANASGNWEELVKYLQMARKKARESYVETELIFALAKTNR 1182
Query: 185 LGEIEEFILMPNVANLPNVGDRLYDEALYEAAKIIYAFTSNWAKLAVTLVKLQQFQSAVD 364
L E+EEFI PN A++ VGDR YDE +Y+AAK++Y SN+ +LA TLV L ++Q+AVD
Sbjct: 1183 LAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVD 1242
Query: 365 AARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSEYYQNRGCFNELISL 544
ARKANS +TWKEVCFACVD +EFRLAQ+CGL+I++ D+LEE+ YYQ+RG F ELI++
Sbjct: 1243 GARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITM 1302
Query: 545 MESGLGLERALMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACDEQQHWQELT 724
+E+ LGLERA MG+FTEL +LY++++ +K+ EH++LF +R+NIPK++RA ++ W EL
Sbjct: 1303 LEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELV 1362
Query: 725 YLYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDIINDL 904
+LY +Y+E+DNA T+MNH +AW+ QFKDI+ KVANVELYYKA+ FYL+ P ++NDL
Sbjct: 1363 FLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYKAIQFYLEFKPLLLNDL 1422
Query: 905 LNVLALRLDHTRVVDIMRKAGQLRLIKPYMVAVQSNNVSAVNEALNEIYVEEEDYDRLRE 1084
L VL+ RLDHTR V+ K QL L+KPY+ +VQ++N +VNE+LN +++ EEDY LR
Sbjct: 1423 LMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRT 1482
Query: 1085 STDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETAS 1264
S D +D+FD I LAQ++EKHEL+E RR+AAY++K RWKQS+ L KKD++YKD M+ AS
Sbjct: 1483 SIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYAS 1542
Query: 1265 QSGDHDLAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMIDFAFPYLLQF 1444
+S D +LAE+LL +F+++ K+ECF CLF CYDL+RPDV LE AW +N++DFA PY +Q
Sbjct: 1543 ESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQV 1602
Query: 1445 IREYSGKVDELIKDKIEAQKEVKAKEQEEKDVMSQQNMYAQLLPLALPA---PPMPGMGG 1615
++EY KV DK++A + ++ +E++ + QL+ A P+ PP G
Sbjct: 1603 MKEYLTKV-----DKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGY 1657
Query: 1616 GPGMGGGYGPPPP 1654
G YG P P
Sbjct: 1658 G-YTAPPYGQPQP 1669
>sp|Q00610|CLH1_HUMAN Clathrin heavy chain 1 OS=Homo sapiens GN=CLTC PE=1 SV=5
Length = 1675
Score = 597 bits (1537), Expect = 2e-169
Identities = 286/553 (51%), Positives = 409/553 (73%), Gaps = 9/553 (1%)
Frame = +2
Query: 5 DAIESFIRADDATHFLEVIRAAEDTNVYDDLVRYLLMVRQKVKEPKVDSELIYAYAKIER 184
+AI+S+I+ADD + ++EV++AA + +++LV+YL M R+K +E V++ELI+A AK R
Sbjct: 1123 EAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNR 1182
Query: 185 LGEIEEFILMPNVANLPNVGDRLYDEALYEAAKIIYAFTSNWAKLAVTLVKLQQFQSAVD 364
L E+EEFI PN A++ VGDR YDE +Y+AAK++Y SN+ +LA TLV L ++Q+AVD
Sbjct: 1183 LAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVD 1242
Query: 365 AARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSEYYQNRGCFNELISL 544
ARKANS +TWKEVCFACVD +EFRLAQ+CGL+I++ D+LEE+ YYQ+RG F ELI++
Sbjct: 1243 GARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITM 1302
Query: 545 MESGLGLERALMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACDEQQHWQELT 724
+E+ LGLERA MG+FTEL +LY++++ +K+ EH++LF +R+NIPK++RA ++ W EL
Sbjct: 1303 LEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELV 1362
Query: 725 YLYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDIINDL 904
+LY +Y+E+DNA T+MNH +AW+ QFKDI+ KVANVELYY+A+ FYL+ P ++NDL
Sbjct: 1363 FLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDL 1422
Query: 905 LNVLALRLDHTRVVDIMRKAGQLRLIKPYMVAVQSNNVSAVNEALNEIYVEEEDYDRLRE 1084
L VL+ RLDHTR V+ K QL L+KPY+ +VQ++N +VNE+LN +++ EEDY LR
Sbjct: 1423 LMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRT 1482
Query: 1085 STDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETAS 1264
S D +D+FD I LAQ++EKHEL+E RR+AAY++K RWKQS+ L KKD++YKD M+ AS
Sbjct: 1483 SIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYAS 1542
Query: 1265 QSGDHDLAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMIDFAFPYLLQF 1444
+S D +LAE+LL +F+++ K+ECF CLF CYDL+RPDV LE AW +N++DFA PY +Q
Sbjct: 1543 ESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQV 1602
Query: 1445 IREYSGKVDELIKDKIEAQKEVKAKEQEEKDVMSQQNMYAQLLPLALPA---PPMPGMGG 1615
++EY KV DK++A + ++ +E++ + QL+ A P+ PP G
Sbjct: 1603 MKEYLTKV-----DKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGY 1657
Query: 1616 GPGMGGGYGPPPP 1654
G YG P P
Sbjct: 1658 G-YTAPPYGQPQP 1669
>sp|P29742|CLH_DROME Clathrin heavy chain OS=Drosophila melanogaster GN=Chc PE=1
SV=1
Length = 1678
Score = 597 bits (1537), Expect = 2e-169
Identities = 291/543 (53%), Positives = 398/543 (73%), Gaps = 8/543 (1%)
Frame = +2
Query: 5 DAIESFIRADDATHFLEVIRAAEDTNVYDDLVRYLLMVRQKVKEPKVDSELIYAYAKIER 184
+AI+S+I+ADD + +++V+ A +DDLVRYL M R+K +E ++SELIYAYA+ R
Sbjct: 1124 EAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARESYIESELIYAYARTGR 1183
Query: 185 LGEIEEFILMPNVANLPNVGDRLYDEALYEAAKIIYAFTSNWAKLAVTLVKLQQFQSAVD 364
L ++EEFI PN A++ +G+R + + +Y+AAK++Y SN+A+LA+TLV L++FQ AVD
Sbjct: 1184 LADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAITLVYLKEFQGAVD 1243
Query: 365 AARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSEYYQNRGCFNELISL 544
+ARKANS +TWKEVCFACVDAEEFRLAQ+CGL+I++ D+LE++ YYQNRG F+ELI+L
Sbjct: 1244 SARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRGYFDELIAL 1303
Query: 545 MESGLGLERALMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACDEQQHWQELT 724
+ES LGLERA MG+FTEL +LY++++ K+ EH++LF +R+NIPK++RA + W EL
Sbjct: 1304 LESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWSELV 1363
Query: 725 YLYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDIINDL 904
+LY +Y+E+DNA +M H EAW FKDI+ KVAN+ELYYKA+ FYL P ++ND+
Sbjct: 1364 FLYDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDM 1423
Query: 905 LNVLALRLDHTRVVDIMRKAGQLRLIKPYMVAVQSNNVSAVNEALNEIYVEEEDYDRLRE 1084
L VLA R+DHTR V K G L L+KPY+ +VQS N A+NEALN + ++EEDY LR
Sbjct: 1424 LLVLAPRMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRN 1483
Query: 1085 STDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETAS 1264
S D D+FD I LAQK+EKHEL E RR+AAY+YK RWKQS+ L KKD +YKD ME A+
Sbjct: 1484 SIDGFDNFDNIALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAA 1543
Query: 1265 QSGDHDLAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMIDFAFPYLLQF 1444
+S D+AE+LL +F+E+ +CFA CL+ CYDL+RPDV LELAW + ++DFA PYL+Q
Sbjct: 1544 ESCKQDIAEELLGWFLERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQV 1603
Query: 1445 IREYSGKVDELIKDKIEAQKEVKAKEQEEKDVMSQQNMYAQLLPLALPA---PPMPGMGG 1615
+REY+ KVD+L + EAQ+E + E K+++ M QL+ A PA PP
Sbjct: 1604 LREYTTKVDKL--ELNEAQREKEDDSTEHKNII---QMEPQLMITAGPAMGIPPQYAQNY 1658
Query: 1616 GPG 1624
PG
Sbjct: 1659 PPG 1661
>sp|P11442|CLH_RAT Clathrin heavy chain 1 OS=Rattus norvegicus GN=Cltc PE=1
SV=3
Length = 1675
Score = 595 bits (1532), Expect = 6e-169
Identities = 286/553 (51%), Positives = 408/553 (73%), Gaps = 9/553 (1%)
Frame = +2
Query: 5 DAIESFIRADDATHFLEVIRAAEDTNVYDDLVRYLLMVRQKVKEPKVDSELIYAYAKIER 184
+AI+S+I+ADD + ++EV++AA + +++LV+YL M R+K +E V++ELI+A AK R
Sbjct: 1123 EAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNR 1182
Query: 185 LGEIEEFILMPNVANLPNVGDRLYDEALYEAAKIIYAFTSNWAKLAVTLVKLQQFQSAVD 364
L E+EEFI PN A++ VGDR YDE +Y+AAK++Y SN+ +LA TLV L ++Q+AVD
Sbjct: 1183 LAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVD 1242
Query: 365 AARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSEYYQNRGCFNELISL 544
ARKANS +TWKEVCFACVD +EFRLAQ+CGL+I++ D+LEE+ YYQ+RG F ELI++
Sbjct: 1243 GARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITM 1302
Query: 545 MESGLGLERALMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACDEQQHWQELT 724
+E+ LGLERA MG+FTEL +LY++++ +K+ EH++LF +R+NIPK++RA ++ W EL
Sbjct: 1303 LEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELV 1362
Query: 725 YLYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDIINDL 904
+LY +Y+E+DNA T+MNH +AW+ QFKDI+ KVANVELYYKA+ FYL+ P ++NDL
Sbjct: 1363 FLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYKAIQFYLEFKPLLLNDL 1422
Query: 905 LNVLALRLDHTRVVDIMRKAGQLRLIKPYMVAVQSNNVSAVNEALNEIYVEEEDYDRLRE 1084
L VL+ RL HTR V+ K QL L+KPY+ +VQ++N +VNE+LN +++ EEDY LR
Sbjct: 1423 LMVLSPRLAHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRT 1482
Query: 1085 STDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETAS 1264
S D +D+FD I LAQ++EKHEL+E RR+AAY++K RWKQS+ L KKD++YKD M+ AS
Sbjct: 1483 SIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYAS 1542
Query: 1265 QSGDHDLAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMIDFAFPYLLQF 1444
+S D +LAE+LL +F+++ K+ECF CLF CYDL+RPDV LE AW +N++DFA PY +Q
Sbjct: 1543 ESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQV 1602
Query: 1445 IREYSGKVDELIKDKIEAQKEVKAKEQEEKDVMSQQNMYAQLLPLALPA---PPMPGMGG 1615
++EY KV DK++A + ++ +E++ + QL+ A P+ PP G
Sbjct: 1603 MKEYLTKV-----DKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGY 1657
Query: 1616 GPGMGGGYGPPPP 1654
G YG P P
Sbjct: 1658 G-YTAPPYGQPQP 1669
>sp|P53675|CLH2_HUMAN Clathrin heavy chain 2 OS=Homo sapiens GN=CLTCL1 PE=1
SV=2
Length = 1640
Score = 577 bits (1487), Expect = 1e-163
Identities = 273/501 (54%), Positives = 387/501 (77%), Gaps = 2/501 (0%)
Frame = +2
Query: 5 DAIESFIRADDATHFLEVIRAAEDTNVYDDLVRYLLMVRQKVKEPKVDSELIYAYAKIER 184
+AI S+IR DD + +LEV+++A +N ++DLV++L M R+K +E +++ELI+A AK R
Sbjct: 1123 EAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSR 1182
Query: 185 LGEIEEFILMPNVANLPNVGDRLYDEALYEAAKIIYAFTSNWAKLAVTLVKLQQFQSAVD 364
+ E+E+FI PN A++ VGDR Y+E +YEAAK++Y+ SN+A+LA TLV L ++Q+AVD
Sbjct: 1183 VSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVD 1242
Query: 365 AARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSEYYQNRGCFNELISL 544
+RKA+S +TWKEVCFAC+D +EFR AQ+CGL+I+I D+LEE+ YYQ+RG F ELI L
Sbjct: 1243 NSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILL 1302
Query: 545 MESGLGLERALMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACDEQQHWQELT 724
+E+ LGLERA MG+FTEL +LY++++ +K++EH++LF +R+NIPK++RA ++ W EL
Sbjct: 1303 LEAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELV 1362
Query: 725 YLYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDIINDL 904
+LY +Y+E+DNA T+M+H EAW+ QFKDI+ KVANVEL Y+A+ FYL P +INDL
Sbjct: 1363 FLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDL 1422
Query: 905 LNVLALRLDHTRVVDIMRKAGQLRLIKPYMVAVQSNNVSAVNEALNEIYVEEEDYDRLRE 1084
L VL+ RLDHT V KAGQL L+KPY+ +VQS+N +VNEALN + EEEDY LR
Sbjct: 1423 LLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRA 1482
Query: 1085 STDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETAS 1264
S D +D+FD I LAQ++EKH+L+E R +AAY+YK W QS+ L KKD++YKD M+ A+
Sbjct: 1483 SIDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAA 1542
Query: 1265 QSGDHDLAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMIDFAFPYLLQF 1444
+S D +LA++LL +F+E+GK+ECFA CLF CYDL+RPD+ LELAW +N++D A PY +Q
Sbjct: 1543 ESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQV 1602
Query: 1445 IREYSGKVDELIKDKIEAQKE 1507
+REY KVD+L D +E+ ++
Sbjct: 1603 MREYLSKVDKL--DALESLRK 1621
>sp|P34574|CLH_CAEEL Probable clathrin heavy chain 1 OS=Caenorhabditis elegans
GN=chc-1 PE=1 SV=1
Length = 1681
Score = 573 bits (1475), Expect = 2e-162
Identities = 277/558 (49%), Positives = 404/558 (72%), Gaps = 10/558 (1%)
Frame = +2
Query: 5 DAIESFIRADDATHFLEVIRAAEDTNVYDDLVRYLLMVRQKVKEPKVDSELIYAYAKIER 184
+A++SFI+ADD ++EV+ T ++DLVRYL M R+K +E +++EL++A AK R
Sbjct: 1125 EAVDSFIKADDPGAYMEVVNKCSQTEHWEDLVRYLQMARKKSRESYIETELVFALAKTGR 1184
Query: 185 LGEIEEFILMPNVANLPNVGDRLYDEALYEAAKIIYAFTSNWAKLAVTLVKLQQFQSAVD 364
L E+EEFI PN A + +GDR +D ++++AKI++ SN+AKL+VTLV+L ++Q AVD
Sbjct: 1185 LTELEEFIAGPNHAQIGQIGDRCFDNGMFDSAKILFNNVSNFAKLSVTLVRLGEYQGAVD 1244
Query: 365 AARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSEYYQNRGCFNELISL 544
AARKANS KTWK+VCF+CV+ EFRLAQ+CGL+I++ D+LEE+ +YQ+RG F ELI+L
Sbjct: 1245 AARKANSTKTWKQVCFSCVENGEFRLAQMCGLHIVVHADELEELINFYQDRGHFEELIAL 1304
Query: 545 MESGLGLERALMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACDEQQHWQELT 724
+E+ LGLERA MG+FTEL +LY++Y+ EK+ EH++LF +R+NIPK++RA ++ W EL
Sbjct: 1305 LEAALGLERAHMGMFTELAILYSKYKPEKMREHLELFWSRVNIPKVLRAAEQAHLWSELV 1364
Query: 725 YLYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDIINDL 904
+LY +Y+E+DNAA T+M H E+W FK+++AKVANVELYYKA+ FYL P ++NDL
Sbjct: 1365 FLYDKYEEYDNAALTMMQHPTESWREQHFKEVIAKVANVELYYKAMQFYLDYKPLLLNDL 1424
Query: 905 LNVLALRLDHTRVVDIMRKAGQLRLIKPYMVAVQSNNVSAVNEALNEIYVEEEDYDRLRE 1084
L VL+ RLDH+R V K Q+ L+KPY+ VQ+ N A+NEALN++ ++EED+ LR
Sbjct: 1425 LTVLSPRLDHSRTVLFFNKLKQIPLVKPYLRQVQNLNNKAINEALNQLLIDEEDHAGLRS 1484
Query: 1085 STDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETAS 1264
S + D+FD I LAQ++EKH LVE RR++AY++K RWKQSI L KKD +YKD ME A+
Sbjct: 1485 SIEAQDNFDNITLAQQLEKHPLVEFRRISAYLFKGNNRWKQSIELCKKDKLYKDAMEYAA 1544
Query: 1265 QSGDHDLAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMIDFAFPYLLQF 1444
+S + +LAE+LL +F+++ +CFA L+ CYDL+ PDV +ELAW + ++D+A PY++Q
Sbjct: 1545 ESRNGELAEELLSFFLDEKLYDCFAASLYHCYDLLHPDVIMELAWKHKIMDYAMPYMIQV 1604
Query: 1445 IREYSGKVDELIKDKIEAQKEVKAKEQEEKDVMSQQNMYAQLLPLALPAPPM--PGMGGG 1618
+R+Y ++++L + + E +KE KA++Q+ + + + +L PAP M PG GG
Sbjct: 1605 MRDYQTRLEKLERSEHE-RKEEKAEQQQNNGMTMEPQL---MLTYGAPAPQMTYPGTTGG 1660
Query: 1619 PGMGGGYGPPPPMGGMPG 1672
G YG P G PG
Sbjct: 1661 YGGQPAYGQP----GQPG 1674
>sp|Q10161|CLH_SCHPO Probable clathrin heavy chain OS=Schizosaccharomyces pombe
GN=chc1 PE=1 SV=1
Length = 1666
Score = 518 bits (1334), Expect = 6e-146
Identities = 253/512 (49%), Positives = 355/512 (69%), Gaps = 2/512 (0%)
Frame = +2
Query: 5 DAIESFIRADDATHFLEVIRAAEDTNVYDDLVRYLLMVRQKVKEPKVDSELIYAYAKIER 184
DAIES+++ADD +++ EVI A Y++L++YLLM R K+ EP VDS L+ AYAK +
Sbjct: 1119 DAIESYLKADDPSNYSEVIELASRAGKYEELIKYLLMARSKMHEPDVDSALLIAYAKTNQ 1178
Query: 185 LGEIEEFILMPNVANLPNVGDRLYDEALYEAAKIIYAFTSNWAKLAVTLVKLQQFQSAVD 364
L E+E F++ NVA++ VGD ++ YEAAK++Y+ SNW+ LA TLV L ++Q AVD
Sbjct: 1179 LTEMETFLIGSNVADVKAVGDECFESKNYEAAKLMYSSISNWSMLATTLVYLGEYQGAVD 1238
Query: 365 AARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSEYYQNRGCFNELISL 544
ARKANS K WK+V AC+D EFRLAQICGLN+I+ ++L + Y+ RG F E+ISL
Sbjct: 1239 CARKANSIKVWKQVGTACIDKREFRLAQICGLNLIVHAEELPGLIRLYEERGYFEEVISL 1298
Query: 545 MESGLGLERALMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACDEQQHWQELT 724
ME+GLGLERA M +TEL +LYA+Y+ E++MEH+KLF RLN+ K+IRACD+ W E
Sbjct: 1299 MEAGLGLERAHMAFYTELAILYAKYKPERMMEHLKLFWGRLNMAKVIRACDQMHLWNEAV 1358
Query: 725 YLYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDIINDL 904
+LY+ +DNAA VM PEA++H FKDI+ VAN+ELYY+A++FYL++HP ++ DL
Sbjct: 1359 FLYVHDQSYDNAA-AVMMEQPEAFDHQSFKDIIVHVANLELYYRALNFYLEQHPMLLTDL 1417
Query: 905 LNVLALRLDHTRVVDIMRKAGQLRLIKPYMVAVQSNNVSAVNEALNEIYVEEEDYDRLRE 1084
L L R+DH RV+ I K+ LI +MVA+Q N+ AVN A N++ +E EDY L++
Sbjct: 1418 LAALTPRIDHPRVIRIFEKSENTPLILNFMVAIQHLNIQAVNHAYNDLLIEMEDYQSLQD 1477
Query: 1085 STDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETAS 1264
S + +D FD I LA+++EKH L+E RR+AAYIY+K RW QSI LSK+D YKD + TA
Sbjct: 1478 SIENYDHFDAIALARRLEKHSLLEFRRIAAYIYRKNKRWTQSIELSKQDRFYKDAIITAR 1537
Query: 1265 QSGDHDLAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMIDFAFPYLLQF 1444
S +AE L+ YF+E G ECFA L+ CY L+R D+ +E++W + D+A+PY + F
Sbjct: 1538 DSDQTTIAEDLMKYFVEIGNYECFAAILYTCYHLLRNDLVMEISWRKGLQDYAYPYFINF 1597
Query: 1445 IREYSGKVDELIKDKIEAQKEVKAKEQEEKDV 1540
E KV L KD ++ ++ VK++E+ +
Sbjct: 1598 QCEMFSKVLNLEKD-LKDRQAVKSEEESASTI 1628
>sp|P22137|CLH_YEAST Clathrin heavy chain OS=Saccharomyces cerevisiae GN=CHC1
PE=1 SV=1
Length = 1653
Score = 478 bits (1228), Expect = 1e-133
Identities = 226/524 (43%), Positives = 362/524 (69%), Gaps = 2/524 (0%)
Frame = +2
Query: 5 DAIESFIRADDATHFLEVIRAAEDTNVYDDLVRYLLMVRQKVKEPKVDSELIYAYAKIER 184
DAIES+I+A+D +++ VI AE Y++L+ +LLM R+ +KEPK+D LI AYA++ +
Sbjct: 1129 DAIESYIKAEDPSNYENVIDIAEQAGKYEELIPFLLMARKTLKEPKIDGALILAYAELNK 1188
Query: 185 LGEIEEFILMPNVANLPNVGDRLYDEALYEAAKIIYAFTSNWAKLAVTLVKLQQFQSAVD 364
+ EIE + NVANL +VGD+L++ Y+AA++ Y+ SN++KLA TLV L +Q+AVD
Sbjct: 1189 IHEIENLLAGSNVANLDHVGDKLFENKEYKAARLCYSAVSNYSKLASTLVYLGDYQAAVD 1248
Query: 365 AARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSEYYQNRGCFNELISL 544
ARKA++ K WK V AC++ +EF+LAQICGLN+I+ ++L+E+ E Y++ G F ELISL
Sbjct: 1249 TARKASNIKVWKLVNDACIEKKEFKLAQICGLNLIVHAEELDELVERYESNGYFEELISL 1308
Query: 545 MESGLGLERALMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACDEQQHWQELT 724
E+GLGLERA MG+FTEL +LY++Y +K EH+KLF +R+NIPK+IRA ++ W EL
Sbjct: 1309 FEAGLGLERAHMGMFTELAILYSKYEPDKTFEHLKLFWSRINIPKVIRAVEQAHLWSELV 1368
Query: 725 YLYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDIINDL 904
+LY YDE+DNAA T++ S + +H FK++V KV+N+E+YYKA++FY++ HP ++ DL
Sbjct: 1369 FLYAHYDEWDNAALTLIEKSTKDLDHAYFKEVVVKVSNLEIYYKAINFYVKFHPSLLVDL 1428
Query: 905 LNVLALRLDHTRVVDIMRKAGQLRLIKPYMVAVQSNNVSAVNEALNEIYVEEEDYDRLRE 1084
L L RLD R V I K+ L LIKP+++ V N S VN+A +++ +EEEDY L++
Sbjct: 1429 LTSLTPRLDIPRTVKIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEEDYKALQD 1488
Query: 1085 STDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETAS 1264
+ D +D FDQ+GLA ++E H+L+ +++ A +Y++ +W +S+++ K++ ++KD +ETA+
Sbjct: 1489 AVDSYDKFDQLGLASRLESHKLIFFKKIGALLYRRNKKWAKSLSILKEEKLWKDAIETAA 1548
Query: 1265 QSGDHDLAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMIDFAFPYLLQF 1444
S D + E LL YF+E G +E F L+ Y+L+R + LE++W+N++ D+ P+ +
Sbjct: 1549 ISQDPKVVEALLTYFVETGNREGFVALLYAAYNLVRIEFVLEISWMNSLEDYIKPFEISI 1608
Query: 1445 IREYSGKVDELIKDKIEAQKEVKAKEQEEKDVMSQQNMYAQLLP 1576
+E + + ++ ++ A+K +E ++ + N + P
Sbjct: 1609 KKEQNDSIKKITEEL--AKKSGSNEEHKDGQPLMLMNSAMNVQP 1650
>sp|Q0IHV1|INF2_XENTR Inverted formin-2 OS=Xenopus tropicalis GN=inf2 PE=2 SV=1
Length = 1380
Score = 54 bits (127), Expect = 5e-006
Identities = 27/48 (56%), Positives = 30/48 (62%), Gaps = 10/48 (20%)
Frame = +2
Query: 1586 PAPPMPGMGGG--------PGMGGGYGPPPPMGGMPGMPPMPP--YGM 1699
P PP+PGMGG PGMGG PPPP+ GM GMPP PP +GM
Sbjct: 523 PPPPLPGMGGMLPPPPPPLPGMGGMPPPPPPLPGMGGMPPPPPPMFGM 570
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,819,846,109
Number of Sequences: 518415
Number of Extensions: 95819846109
Number of Successful Extensions: 619733697
Number of sequences better than 0.0: 0
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