BLASTX 7.6.2
Query= UN22689 /QuerySize=1642
(1641 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabi... 143 5e-033
sp|Q05609|CTR1_ARATH Serine/threonine-protein kinase CTR1 OS=Ara... 124 2e-027
sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase ki... 118 1e-025
sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase ki... 118 1e-025
sp|A7J1T0|M313B_XENLA Mitogen-activated protein kinase kinase ki... 118 2e-025
sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kina... 117 2e-025
sp|Q54U31|SHKD_DICDI Dual specificity protein kinase shkD OS=Dic... 117 3e-025
sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kin... 115 1e-024
sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kin... 115 1e-024
sp|Q23915|KINX_DICDI Probable serine/threonine-protein kinase ki... 106 9e-022
sp|A8X775|DLK1_CAEBR Mitogen-activated protein kinase kinase kin... 105 1e-021
sp|O01700|DLK1_CAEEL Mitogen-activated protein kinase kinase kin... 102 1e-020
sp|P18160|PYK1_DICDI Dual specificity protein kinase pyk1 OS=Dic... 93 4e-018
sp|Q552C1|Y9957_DICDI Probable serine/threonine-protein kinase D... 88 2e-016
sp|Q9Y243|AKT3_HUMAN RAC-gamma serine/threonine-protein kinase O... 86 5e-016
sp|Q9WUA6|AKT3_MOUSE RAC-gamma serine/threonine-protein kinase O... 86 5e-016
sp|Q63484|AKT3_RAT RAC-gamma serine/threonine-protein kinase OS=... 86 5e-016
sp|P47197|AKT2_RAT RAC-beta serine/threonine-protein kinase OS=R... 82 8e-015
sp|P31751|AKT2_HUMAN RAC-beta serine/threonine-protein kinase OS... 82 1e-014
sp|Q60823|AKT2_MOUSE RAC-beta serine/threonine-protein kinase OS... 82 1e-014
>sp|Q2MHE4|HT1_ARATH Serine/threonine-protein kinase HT1 OS=Arabidopsis thaliana
GN=HT1 PE=1 SV=1
Length = 390
Score = 143 bits (359), Expect = 5e-033
Identities = 69/187 (36%), Positives = 111/187 (59%), Gaps = 1/187 (0%)
Frame = +1
Query: 751 IYVVLLLSIFKWCFEILLDQEQKKKVSI*SCCSARS*LARGLSYLHSPKIVHRDVKTENM 930
+Y ++ + + + L++++ +SI + ++RG+ YLHS ++HRD+K+ N+
Sbjct: 159 VYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQGVIHRDLKSNNL 218
Query: 931 LLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMAPEVLNGNPYNRKCDVYSFGICLW 1110
LL+ VK+ADFG + +E + + G GT +MAPE++ PY RK DVYSFGI LW
Sbjct: 219 LLNDEMRVKVADFGTSCLE-TQCREAKGNMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLW 277
Query: 1111 EIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCCPSSLAAVMKRCWDANPDKRPEMDEVV 1290
E+ +P+ +T + AV +N RP +P C +LA ++KRCW NP KRP+ +V
Sbjct: 278 ELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLIKRCWSENPSKRPDFSNIV 337
Query: 1291 PMLENID 1311
+LE D
Sbjct: 338 AVLEKYD 344
>sp|Q05609|CTR1_ARATH Serine/threonine-protein kinase CTR1 OS=Arabidopsis
thaliana GN=CTR1 PE=1 SV=1
Length = 821
Score = 124 bits (311), Expect = 2e-027
Identities = 63/148 (42%), Positives = 94/148 (63%), Gaps = 2/148 (1%)
Frame = +1
Query: 862 LARGLSYLH--SPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGY 1035
+A+G++YLH +P IVHRD+K+ N+L+DK TVK+ DFG++R++AS GT +
Sbjct: 658 VAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEW 717
Query: 1036 MAPEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCCP 1215
MAPEVL P N K DVYSFG+ LWE+ P+ +L ++V +AV + R +IPR
Sbjct: 718 MAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLN 777
Query: 1216 SSLAAVMKRCWDANPDKRPEMDEVVPML 1299
+AA+++ CW P KRP ++ +L
Sbjct: 778 PQVAAIIEGCWTNEPWKRPSFATIMDLL 805
>sp|Q12852|M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 OS=Homo
sapiens GN=MAP3K12 PE=1 SV=2
Length = 859
Score = 118 bits (295), Expect = 1e-025
Identities = 53/147 (36%), Positives = 89/147 (60%), Gaps = 1/147 (0%)
Frame = +1
Query: 862 LARGLSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMA 1041
+A G++YLH KI+HRD+K+ NML+ VKI+DFG ++ E S+ + GT+ +MA
Sbjct: 220 IAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSK-ELSDKSTKMSFAGTVAWMA 278
Query: 1042 PEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCCPSS 1221
PEV+ P + K D++SFG+ LWE+ ++PY D+ S + V +L +P CP
Sbjct: 279 PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDG 338
Query: 1222 LAAVMKRCWDANPDKRPEMDEVVPMLE 1302
++++CW++ P RP +++ L+
Sbjct: 339 FKILLRQCWNSKPRNRPSFRQILLHLD 365
>sp|Q60700|M3K12_MOUSE Mitogen-activated protein kinase kinase kinase 12 OS=Mus
musculus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 118 bits (295), Expect = 1e-025
Identities = 53/147 (36%), Positives = 89/147 (60%), Gaps = 1/147 (0%)
Frame = +1
Query: 862 LARGLSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMA 1041
+A G++YLH KI+HRD+K+ NML+ VKI+DFG ++ E S+ + GT+ +MA
Sbjct: 253 IAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSK-ELSDKSTKMSFAGTVAWMA 311
Query: 1042 PEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCCPSS 1221
PEV+ P + K D++SFG+ LWE+ ++PY D+ S + V +L +P CP
Sbjct: 312 PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDG 371
Query: 1222 LAAVMKRCWDANPDKRPEMDEVVPMLE 1302
++++CW++ P RP +++ L+
Sbjct: 372 FKILLRQCWNSKPRNRPSFRQILLHLD 398
>sp|A7J1T0|M313B_XENLA Mitogen-activated protein kinase kinase kinase 13-B
OS=Xenopus laevis GN=map3k13-b PE=2 SV=1
Length = 961
Score = 118 bits (294), Expect = 2e-025
Identities = 54/147 (36%), Positives = 88/147 (59%), Gaps = 1/147 (0%)
Frame = +1
Query: 862 LARGLSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMA 1041
+A G++YLH KI+HRD+K+ N+L+ TVKI+DFG ++ E S+ + GT+ +MA
Sbjct: 266 IASGMNYLHLHKIIHRDLKSPNVLVTHADTVKISDFGTSK-ELSDKSTKMSFAGTVAWMA 324
Query: 1042 PEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCCPSS 1221
PEV+ P + K D++SFG+ LWE+ ++PY D+ S + V +L +P CP
Sbjct: 325 PEVIRNEPVSEKVDIWSFGVLLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDG 384
Query: 1222 LAAVMKRCWDANPDKRPEMDEVVPMLE 1302
+MK+ W + P RP +++ L+
Sbjct: 385 FKILMKQTWQSKPRNRPSFRQILMHLD 411
>sp|Q63796|M3K12_RAT Mitogen-activated protein kinase kinase kinase 12 OS=Rattus
norvegicus GN=Map3k12 PE=1 SV=1
Length = 888
Score = 117 bits (293), Expect = 2e-025
Identities = 53/147 (36%), Positives = 88/147 (59%), Gaps = 1/147 (0%)
Frame = +1
Query: 862 LARGLSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMA 1041
+A G++YLH KI+HRD+K+ NML+ VKI+DFG ++ E S+ + GT+ +MA
Sbjct: 253 IAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSK-ELSDKSTKMSFAGTVAWMA 311
Query: 1042 PEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCCPSS 1221
PEV+ P + K D++SFG+ LWE+ ++PY D+ S + V +L +P CP
Sbjct: 312 PEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDG 371
Query: 1222 LAAVMKRCWDANPDKRPEMDEVVPMLE 1302
++++CW+ P RP +++ L+
Sbjct: 372 FKILLRQCWNRKPRNRPSFRQILLHLD 398
>sp|Q54U31|SHKD_DICDI Dual specificity protein kinase shkD OS=Dictyostelium
discoideum GN=shkD PE=3 SV=1
Length = 744
Score = 117 bits (292), Expect = 3e-025
Identities = 65/174 (37%), Positives = 94/174 (54%), Gaps = 2/174 (1%)
Frame = +1
Query: 793 EILLDQEQKKKVSI*SCCSARS*LARGLSYLHS-PKIVHRDVKTENMLLDKTRTVKIADF 969
++L + KK+ S+ A G+++LH +IVH D+KT N+L+D VK+ DF
Sbjct: 360 KLLHNDRTKKEFSLFRRMQMAKDAALGMNWLHGITRIVHNDLKTANLLVDINLRVKVTDF 419
Query: 970 GVARVEASNPNDMTGETGTLGYMAPEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYP-DL 1146
G ++++ GT +MAPEV+ GNPYN K DVYSFGI LWEI + PY
Sbjct: 420 GFSQIKEGEEFQDKAAKGTPLWMAPEVMMGNPYNEKADVYSFGIILWEILTKEAPYSHHK 479
Query: 1147 TFSEVTSAVVRQNLRPDIPRCCPSSLAAVMKRCWDANPDKRPEMDEVVPMLENI 1308
+ +A+ + RP IP SL +++ CWD NP RP E++ L I
Sbjct: 480 DYDIFFNAICNEKERPPIPADTLPSLRHLIQTCWDHNPQNRPSFSEILFRLNEI 533
>sp|Q9NYL2|MLTK_HUMAN Mitogen-activated protein kinase kinase kinase MLT OS=Homo
sapiens GN=MLTK PE=1 SV=2
Length = 800
Score = 115 bits (287), Expect = 1e-024
Identities = 55/152 (36%), Positives = 89/152 (58%), Gaps = 5/152 (3%)
Frame = +1
Query: 862 LARGLSYLHSP---KIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLG 1032
+A+G+ YLH K++HRD+K+ N+++ +KI DFG +R N GT
Sbjct: 114 VAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFH--NHTTHMSLVGTFP 171
Query: 1033 YMAPEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCC 1212
+MAPEV+ P + CD YS+G+ LWE+ ++P+ L +V VV +N R IP C
Sbjct: 172 WMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSC 231
Query: 1213 PSSLAAVMKRCWDANPDKRPEMDEVVPMLENI 1308
P S A ++ +CW+A+ KRP +++ +LE++
Sbjct: 232 PRSFAELLHQCWEADAKKRPSFKQIISILESM 263
>sp|Q9ESL4|MLTK_MOUSE Mitogen-activated protein kinase kinase kinase MLT OS=Mus
musculus GN=Mltk PE=1 SV=1
Length = 802
Score = 115 bits (287), Expect = 1e-024
Identities = 55/152 (36%), Positives = 89/152 (58%), Gaps = 5/152 (3%)
Frame = +1
Query: 862 LARGLSYLHSP---KIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLG 1032
+A+G+ YLH K++HRD+K+ N+++ +KI DFG +R N GT
Sbjct: 114 VAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFH--NHTTHMSLVGTFP 171
Query: 1033 YMAPEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCC 1212
+MAPEV+ P + CD YS+G+ LWE+ ++P+ L +V VV +N R IP C
Sbjct: 172 WMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSC 231
Query: 1213 PSSLAAVMKRCWDANPDKRPEMDEVVPMLENI 1308
P S A ++ +CW+A+ KRP +++ +LE++
Sbjct: 232 PRSFAELLHQCWEADAKKRPSFKQIISILESM 263
>sp|Q23915|KINX_DICDI Probable serine/threonine-protein kinase kinX
OS=Dictyostelium discoideum GN=kinX PE=3 SV=2
Length = 1094
Score = 106 bits (262), Expect = 9e-022
Identities = 59/157 (37%), Positives = 86/157 (54%), Gaps = 7/157 (4%)
Frame = +1
Query: 874 LSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMAPEVL 1053
+SYLHS IVHRD+K+ N+L+DK +K+ DFG AR+ + N GT +M+PE++
Sbjct: 134 MSYLHSKSIVHRDLKSTNLLVDKNWKIKVCDFGFARIVEEDNNKSMTICGTDNWMSPEMI 193
Query: 1054 NGNPYNRKCDVYSFGICLWEIYCCDMPYP---DLTFSEVTSAVVRQNLRPDIPRCCPSSL 1224
G Y+ + D++SFGI L EI P P D +F + +VR L IP CP SL
Sbjct: 194 TGLDYDERSDIFSFGIVLLEIISRVKPAPYMRDASFG-LAEDIVRNQL---IPTDCPESL 249
Query: 1225 AAVMKRCWDANPDKRPEMDEVVPMLENIDTTKGGGMI 1335
+ C +P+ RP E+ L+ I TT ++
Sbjct: 250 IDLTFNCCSVDPNNRPSFKEISQTLKQIKTTLDSNIV 286
>sp|A8X775|DLK1_CAEBR Mitogen-activated protein kinase kinase kinase dlk-1
OS=Caenorhabditis briggsae GN=dlk-1 PE=3 SV=1
Length = 857
Score = 105 bits (261), Expect = 1e-021
Identities = 48/142 (33%), Positives = 77/142 (54%)
Frame = +1
Query: 862 LARGLSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMA 1041
+A G+ YLH K++HRD+K+ N+L+ ++KI DFG + ++ N + M GT+ +MA
Sbjct: 157 IADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHLQKKNDSTMMSFCGTVSWMA 216
Query: 1042 PEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCCPSS 1221
PE++ P N K DVYSFG+ LWE+ + PY ++ + V L +P P
Sbjct: 217 PEMIKKEPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVGTNILNLPMPEEAPRG 276
Query: 1222 LAAVMKRCWDANPDKRPEMDEV 1287
L ++K+C RP +
Sbjct: 277 LVLLIKQCLSQKGRNRPSFSHI 298
>sp|O01700|DLK1_CAEEL Mitogen-activated protein kinase kinase kinase dlk-1
OS=Caenorhabditis elegans GN=dlk-1 PE=1 SV=4
Length = 928
Score = 102 bits (253), Expect = 1e-020
Identities = 47/142 (33%), Positives = 76/142 (53%)
Frame = +1
Query: 862 LARGLSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMA 1041
+A G+ YLH K++HRD+K+ N+L+ ++KI DFG + ++ + M GT+ +MA
Sbjct: 230 IADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHMQKKMDSTMMSFCGTVSWMA 289
Query: 1042 PEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCCPSS 1221
PE++ P N K DVYSFG+ LWE+ + PY ++ + V L +P P
Sbjct: 290 PEMIKKQPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVGTNILSLPMPEEAPKG 349
Query: 1222 LAAVMKRCWDANPDKRPEMDEV 1287
L ++K+C RP +
Sbjct: 350 LVLLIKQCLSQKGRNRPSFSHI 371
>sp|P18160|PYK1_DICDI Dual specificity protein kinase pyk1 OS=Dictyostelium
discoideum GN=splA PE=1 SV=3
Length = 2410
Score = 93 bits (230), Expect = 4e-018
Identities = 41/119 (34%), Positives = 69/119 (57%)
Frame = +1
Query: 955 KIADFGVARVEASNPNDMTGETGTLGYMAPEVLNGNPYNRKCDVYSFGICLWEIYCCDMP 1134
KI+DFG++R++ + MT G + YMAPEV G+ + K DVYS+G+ L+E+ D P
Sbjct: 2271 KISDFGLSRLKMEQASQMTQSVGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLTSDEP 2330
Query: 1135 YPDLTFSEVTSAVVRQNLRPDIPRCCPSSLAAVMKRCWDANPDKRPEMDEVVPMLENID 1311
D+ ++ ++ RP IP S ++ +CWD+NPD RP +++ L+ ++
Sbjct: 2331 QQDMKPMKMAHLAAYESYRPPIPLTTSSKWKEILTQCWDSNPDSRPTFKQIIVHLKEME 2389
>sp|Q552C1|Y9957_DICDI Probable serine/threonine-protein kinase DDB_G0276181
OS=Dictyostelium discoideum GN=DDB_G0276181 PE=3 SV=1
Length = 1555
Score = 88 bits (216), Expect = 2e-016
Identities = 42/114 (36%), Positives = 65/114 (57%), Gaps = 4/114 (3%)
Frame = +1
Query: 991 SNPNDMTGETGTLGYMAPEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSA 1170
+N + + GT +MAPEV+ G Y+ KCDVYSF I +WE+ +PY + F+
Sbjct: 1203 NNKVEKDSKKGTTLWMAPEVIRGAMYSEKCDVYSFAIIMWEMVTRKLPYSHIAFNCEVED 1262
Query: 1171 VVRQNLRPDIPRCCPSSLAAVMKRCWDANPDKRPEMDEVV----PMLENIDTTK 1320
V + LRP IP C + +M++CWD +P+ RP D ++ M+E+ D T+
Sbjct: 1263 QVLKGLRPPIPMHCNKNYTDLMEQCWDDDPENRPYFDTIIHSISKMIESNDITE 1316
>sp|Q9Y243|AKT3_HUMAN RAC-gamma serine/threonine-protein kinase OS=Homo sapiens
GN=AKT3 PE=1 SV=1
Length = 479
Score = 86 bits (212), Expect = 5e-016
Identities = 44/136 (32%), Positives = 76/136 (55%), Gaps = 2/136 (1%)
Frame = +1
Query: 862 LARGLSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMA 1041
+ L YLHS KIV+RD+K EN++LDK +KI DFG+ + ++ M GT Y+A
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLA 314
Query: 1042 PEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCCPSS 1221
PEVL N Y R D + G+ ++E+ C +P+ + ++ ++ ++++ PR S
Sbjct: 315 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIK--FPRTLSSD 372
Query: 1222 LAAVMKRCWDANPDKR 1269
+++ +P+KR
Sbjct: 373 AKSLLSGLLIKDPNKR 388
>sp|Q9WUA6|AKT3_MOUSE RAC-gamma serine/threonine-protein kinase OS=Mus musculus
GN=Akt3 PE=2 SV=1
Length = 479
Score = 86 bits (212), Expect = 5e-016
Identities = 44/136 (32%), Positives = 76/136 (55%), Gaps = 2/136 (1%)
Frame = +1
Query: 862 LARGLSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMA 1041
+ L YLHS KIV+RD+K EN++LDK +KI DFG+ + ++ M GT Y+A
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLA 314
Query: 1042 PEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCCPSS 1221
PEVL N Y R D + G+ ++E+ C +P+ + ++ ++ ++++ PR S
Sbjct: 315 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIK--FPRTLSSD 372
Query: 1222 LAAVMKRCWDANPDKR 1269
+++ +P+KR
Sbjct: 373 AKSLLSGLLIKDPNKR 388
>sp|Q63484|AKT3_RAT RAC-gamma serine/threonine-protein kinase OS=Rattus
norvegicus GN=Akt3 PE=2 SV=2
Length = 479
Score = 86 bits (212), Expect = 5e-016
Identities = 44/136 (32%), Positives = 76/136 (55%), Gaps = 2/136 (1%)
Frame = +1
Query: 862 LARGLSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMA 1041
+ L YLHS KIV+RD+K EN++LDK +KI DFG+ + ++ M GT Y+A
Sbjct: 255 IVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLA 314
Query: 1042 PEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRCCPSS 1221
PEVL N Y R D + G+ ++E+ C +P+ + ++ ++ ++++ PR S
Sbjct: 315 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIK--FPRTLSSD 372
Query: 1222 LAAVMKRCWDANPDKR 1269
+++ +P+KR
Sbjct: 373 AKSLLSGLLIKDPNKR 388
>sp|P47197|AKT2_RAT RAC-beta serine/threonine-protein kinase OS=Rattus
norvegicus GN=Akt2 PE=2 SV=1
Length = 481
Score = 82 bits (202), Expect = 8e-015
Identities = 44/131 (33%), Positives = 72/131 (54%), Gaps = 6/131 (4%)
Frame = +1
Query: 862 LARGLSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMA 1041
+ L YLHS +V+RD+K EN++LDK +KI DFG+++ S+ M GT Y+A
Sbjct: 259 IVSALEYLHSTDVVYRDIKLENLMLDKDGHIKITDFGLSKEGISDGATMKTFCGTPEYLA 318
Query: 1042 PEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRC---- 1209
PEVL N Y R D + G+ ++E+ C +P+ + + ++ + +R PR
Sbjct: 319 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIR--FPRTLGPE 376
Query: 1210 CPSSLAAVMKR 1242
S LA ++K+
Sbjct: 377 AKSLLAGLLKK 387
>sp|P31751|AKT2_HUMAN RAC-beta serine/threonine-protein kinase OS=Homo sapiens
GN=AKT2 PE=1 SV=2
Length = 481
Score = 82 bits (200), Expect = 1e-014
Identities = 44/131 (33%), Positives = 71/131 (54%), Gaps = 6/131 (4%)
Frame = +1
Query: 862 LARGLSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMA 1041
+ L YLHS +V+RD+K EN++LDK +KI DFG+ + S+ M GT Y+A
Sbjct: 259 IVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLA 318
Query: 1042 PEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRC---- 1209
PEVL N Y R D + G+ ++E+ C +P+ + + ++ + +R PR
Sbjct: 319 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIR--FPRTLSPE 376
Query: 1210 CPSSLAAVMKR 1242
S LA ++K+
Sbjct: 377 AKSLLAGLLKK 387
>sp|Q60823|AKT2_MOUSE RAC-beta serine/threonine-protein kinase OS=Mus musculus
GN=Akt2 PE=2 SV=1
Length = 481
Score = 82 bits (200), Expect = 1e-014
Identities = 44/131 (33%), Positives = 71/131 (54%), Gaps = 6/131 (4%)
Frame = +1
Query: 862 LARGLSYLHSPKIVHRDVKTENMLLDKTRTVKIADFGVARVEASNPNDMTGETGTLGYMA 1041
+ L YLHS +V+RD+K EN++LDK +KI DFG+ + S+ M GT Y+A
Sbjct: 259 IVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLA 318
Query: 1042 PEVLNGNPYNRKCDVYSFGICLWEIYCCDMPYPDLTFSEVTSAVVRQNLRPDIPRC---- 1209
PEVL N Y R D + G+ ++E+ C +P+ + + ++ + +R PR
Sbjct: 319 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIR--FPRTLGPE 376
Query: 1210 CPSSLAAVMKR 1242
S LA ++K+
Sbjct: 377 AKSLLAGLLKK 387
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,819,846,109
Number of Sequences: 518415
Number of Extensions: 95819846109
Number of Successful Extensions: 619733697
Number of sequences better than 0.0: 0
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