BLASTX 7.6.2
Query= UN23138 /QuerySize=1262
(1261 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9NUN7|ACER3_HUMAN Alkaline ceramidase 3 OS=Homo sapiens GN=A... 126 3e-028
sp|P38298|YPC1_YEAST Alkaline ceramidase YPC1 OS=Saccharomyces c... 79 8e-014
sp|Q02896|YDC1_YEAST Alkaline ceramidase YDC1 OS=Saccharomyces c... 78 1e-013
sp|Q8TDN7|ACER1_HUMAN Alkaline ceramidase 1 OS=Homo sapiens GN=A... 62 1e-008
sp|Q9VIP7|ACASE_DROME Alkaline ceramidase OS=Drosophila melanoga... 57 3e-007
sp|Q8R4X1|ACER1_MOUSE Alkaline ceramidase 1 OS=Mus musculus GN=A... 56 4e-007
sp|Q5QJU3|ACER2_HUMAN Alkaline ceramidase 2 OS=Homo sapiens GN=A... 54 2e-006
>sp|Q9NUN7|ACER3_HUMAN Alkaline ceramidase 3 OS=Homo sapiens GN=ACER3 PE=1 SV=3
Length = 267
Score = 126 bits (316), Expect = 3e-028
Identities = 72/258 (27%), Positives = 128/258 (49%), Gaps = 20/258 (7%)
Frame = -2
Query: 939 FWGPVTSTIECCEKNYAYSSYIAEFYNTISNVPGILLALIGLVNALRQRFEKRFSILHIS 760
+WGP TST++ CE+NY+ + YIAEF+NT+SN+ I+ + G V ++R EKR+ +++
Sbjct: 10 YWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLA 69
Query: 759 NMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILY-------SPDWHYRSTMPTFL 601
++ +GS +H TL++ Q DE PM++ +++Y ++ S ++H T L
Sbjct: 70 LTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYHLLFT----L 125
Query: 600 FLYGAAFAAVHAFLRFGIGFKVHYVVLCLLCIPRMYKYYIHTEDTAAKRIAKWYVATILV 421
L+ V+ ++ I +V Y +L + R Y + + + + L+
Sbjct: 126 VLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSI-YIVTWVYPWLRGLGYTSLGIFLL 184
Query: 420 GSVCWFCDRVFCERISQW--------PVNPQGHALWHVFMSFNSYCANTFLMFCRAQQRG 265
G + W D +FCE + + + Q HA WH+ SY F ++ R
Sbjct: 185 GFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRTLYLR 244
Query: 264 WNPKVKYFLGVLPYVKIE 211
+ PKVK+ G+ P + E
Sbjct: 245 YRPKVKFLFGIWPVILFE 262
>sp|P38298|YPC1_YEAST Alkaline ceramidase YPC1 OS=Saccharomyces cerevisiae
GN=YPC1 PE=1 SV=1
Length = 316
Score = 79 bits (192), Expect = 8e-014
Identities = 37/96 (38%), Positives = 59/96 (61%)
Frame = -2
Query: 948 ISSFWGPVTSTIECCEKNYAYSSYIAEFYNTISNVPGILLALIGLVNALRQRFEKRFSIL 769
+ WG TSTI+ CE+NY S YIAE+ NT++N IL A+ +A + + EKRF ++
Sbjct: 13 VPGVWGETTSTIDWCEENYVVSPYIAEWSNTLTNSVFILSAIYTTYSAYKNKLEKRFLLI 72
Query: 768 HISNMILAIGSMLYHATLQHVQQQSDETPMVWEILL 661
++ +GS L+H TL++ Q DE PM++ + +
Sbjct: 73 GFGYGLVGVGSWLFHMTLKYRFQLLDELPMIYAMCI 108
>sp|Q02896|YDC1_YEAST Alkaline ceramidase YDC1 OS=Saccharomyces cerevisiae
GN=YDC1 PE=1 SV=1
Length = 317
Score = 78 bits (191), Expect = 1e-013
Identities = 37/103 (35%), Positives = 62/103 (60%)
Frame = -2
Query: 948 ISSFWGPVTSTIECCEKNYAYSSYIAEFYNTISNVPGILLALIGLVNALRQRFEKRFSIL 769
I +WG TS I+ CE+NY S YIAE+ NTI+N ++ A +A R + E R+ ++
Sbjct: 12 IEGYWGKPTSLIDWCEENYVVSPYIAEWSNTITNSIFLMTAFYSTYSAWRNKLETRYILI 71
Query: 768 HISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYS 640
+ ++ IGS L+H TLQ+ Q DE PM++ ++ + +++
Sbjct: 72 GMGFSLVGIGSWLFHMTLQYRYQLLDELPMLYATIIPSWSIFA 114
>sp|Q8TDN7|ACER1_HUMAN Alkaline ceramidase 1 OS=Homo sapiens GN=ACER1 PE=2 SV=1
Length = 264
Score = 62 bits (148), Expect = 1e-008
Identities = 35/110 (31%), Positives = 61/110 (55%), Gaps = 7/110 (6%)
Frame = -2
Query: 924 TSTIECCEKNYAYSSYIAEFYNTISNVPGILLA--LIGLVNALRQRFEKRFSILHISNMI 751
+S ++ CE N+ YS +AEFYNT SN+P + ++ L++ Q+ + ++ + MI
Sbjct: 9 SSEVDWCESNFQYSELVAEFYNTFSNIPFFIFGPLMMLLMHPYAQKRSRYIYVVWVLFMI 68
Query: 750 LAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWHYRSTMPTFL 601
+ + SM +H TL + Q DE ++W +L Y ++ P R P+FL
Sbjct: 69 IGLFSMYFHMTLSFLGQLLDEIAILW-LLGSGYSIWMP----RCYFPSFL 113
>sp|Q9VIP7|ACASE_DROME Alkaline ceramidase OS=Drosophila melanogaster GN=bwa
PE=2 SV=2
Length = 283
Score = 57 bits (136), Expect = 3e-007
Identities = 35/104 (33%), Positives = 55/104 (52%), Gaps = 3/104 (2%)
Frame = -2
Query: 930 PVTSTIECCEKNYAYSSYIAEFYNTISNVPGILL--ALIGLVNALRQRFEKRFSILHISN 757
P +S ++ CE NY SS IAEF NT SN ILL LI L + ++ +
Sbjct: 22 PGSSPVDWCEGNYLISSNIAEFVNTFSNFLFILLPPVLIMLFKEYGRFVTPGIHVIWVLL 81
Query: 756 MILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWHY 625
+++ + SM +HATL + Q DE ++W + + + L+ P +Y
Sbjct: 82 IVVGLSSMYFHATLSLIGQLLDELAILW-VFMAAFSLFYPKRYY 124
>sp|Q8R4X1|ACER1_MOUSE Alkaline ceramidase 1 OS=Mus musculus GN=Acer1 PE=1 SV=1
Length = 273
Score = 56 bits (134), Expect = 4e-007
Identities = 32/110 (29%), Positives = 62/110 (56%), Gaps = 3/110 (2%)
Frame = -2
Query: 948 ISSFWGPVTSTIECCEKNYAYSSYIAEFYNTISNVPGILLA--LIGLVNALRQRFEKRFS 775
+SS + +S ++ CE N+ +S +AEFYNT SNV ++ ++ L++ Q+ + F
Sbjct: 10 MSSIFAYQSSEVDWCESNFQHSELVAEFYNTFSNVFFLIFGPLMMFLMHPYAQKRTRCFY 69
Query: 774 ILHISNMILAIGSMLYHATLQHVQQQSDETPMVWEILLYMYILYSPDWHY 625
+ + M++ + SM +H TL + Q DE ++W +L Y ++ P ++
Sbjct: 70 GVSVLFMLIGLFSMYFHMTLSFLGQLLDEISILW-LLASGYSVWLPRCYF 118
>sp|Q5QJU3|ACER2_HUMAN Alkaline ceramidase 2 OS=Homo sapiens GN=ACER2 PE=2 SV=2
Length = 275
Score = 54 bits (128), Expect = 2e-006
Identities = 31/89 (34%), Positives = 47/89 (52%), Gaps = 2/89 (2%)
Frame = -2
Query: 924 TSTIECCEKNYAYSSYIAEFYNTISNVPGILLALI--GLVNALRQRFEKRFSILHISNMI 751
+S ++ CE NY IAEFYNTISNV +L I L F ++ ++
Sbjct: 14 SSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCFNSGIYLIWTLLVV 73
Query: 750 LAIGSMLYHATLQHVQQQSDETPMVWEIL 664
+ IGS+ +HATL + Q DE ++W ++
Sbjct: 74 VGIGSVYFHATLSFLGQMLDELAVLWVLM 102
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,819,846,109
Number of Sequences: 518415
Number of Extensions: 95819846109
Number of Successful Extensions: 619733697
Number of sequences better than 0.0: 0
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