BLASTX 7.6.2
Query= UN23290 /QuerySize=1551
(1550 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P91622|PDK_DROME [Pyruvate dehydrogenase [lipoamide]] kinase,... 243 3e-063
sp|Q9P6P9|PDK_SCHPO [Pyruvate dehydrogenase [lipoamide]] kinase,... 238 1e-061
sp|Q15119|PDK2_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase... 237 2e-061
sp|Q64536|PDK2_RAT [Pyruvate dehydrogenase [lipoamide]] kinase i... 237 2e-061
sp|Q9JK42|PDK2_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase... 236 3e-061
sp|Q8BFP9|PDK1_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase... 235 1e-060
sp|Q63065|PDK1_RAT [Pyruvate dehydrogenase [lipoamide]] kinase i... 233 4e-060
sp|Q15118|PDK1_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase... 229 5e-059
sp|Q15120|PDK3_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase... 226 4e-058
sp|O70571|PDK4_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase... 226 4e-058
sp|Q16654|PDK4_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase... 223 3e-057
sp|O88345|PDK4_SPETR [Pyruvate dehydrogenase [lipoamide]] kinase... 223 3e-057
sp|Q922H2|PDK3_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase... 221 1e-056
sp|O54937|PDK4_RAT [Pyruvate dehydrogenase [lipoamide]] kinase i... 220 2e-056
sp|Q1KMR4|PDK4_RHIFE [Pyruvate dehydrogenase [lipoamide]] kinase... 218 1e-055
sp|O02623|PDK_ASCSU [Pyruvate dehydrogenase [lipoamide]] kinase,... 216 4e-055
sp|Q02332|PDHK2_CAEEL Probable [pyruvate dehydrogenase [lipoamid... 203 3e-051
sp|O14874|BCKD_HUMAN [3-methyl-2-oxobutanoate dehydrogenase [lip... 175 8e-043
sp|Q2KJG8|BCKD_BOVIN [3-methyl-2-oxobutanoate dehydrogenase [lip... 175 1e-042
sp|Q00972|BCKD_RAT [3-methyl-2-oxobutanoate dehydrogenase [lipoa... 174 1e-042
>sp|P91622|PDK_DROME [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial
OS=Drosophila melanogaster GN=Pdk PE=2 SV=2
Length = 413
Score = 243 bits (619), Expect = 3e-063
Identities = 141/352 (40%), Positives = 205/352 (58%), Gaps = 23/352 (6%)
Frame = +3
Query: 234 VSLRYMMEFGSTPTERNLLISAQFLHKELPIRIARRAIELETLPYGLSEKPAVLKVRDWY 413
+S++ M+FG E+ I FL KELP+R+A E+ LP L +V +V WY
Sbjct: 33 LSIKQFMDFGQNACEKKSYI---FLRKELPVRLANIMKEIALLPDNLLHTRSVSEVSSWY 89
Query: 414 VESFRDMRAFPEIKDTADE-KEFTQMIKAVKVRHNNVVPMMALGVNQLKK---GMRLYEN 581
V+SF D+ + + + T D ++F + ++ RHN+VV MA GV ++K+ G
Sbjct: 90 VKSFEDVLVYEKAEPTHDNLQKFVADLDLIRNRHNDVVQTMAQGVIEMKENEGGQVDAPT 149
Query: 582 LDEIHQFLDRFYLSRIGIRMLIGQHVELHNPNPPL--HTVGYIHTKMSPMEVARNASEDA 755
I FLDR Y+SRI IRMLI QH L NP +G + +V R+A E+A
Sbjct: 150 ESSIQYFLDRLYMSRISIRMLINQHTLLFGGNPHAGGRHIGCLDPACDLSDVVRDAYENA 209
Query: 756 RSICFREYGSAPEINIY---GDPSFTFP----YVPTHLHLMVYELVKNSLRAVQERF-VD 911
R +C + Y ++P + I +P P YVP+HL+ M++EL KNS+RAV E D
Sbjct: 210 RFLCDQYYLTSPALEIQQHSSEPGDNLPIRTVYVPSHLYYMLFELFKNSMRAVVEHHGHD 269
Query: 912 SDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTARNPLEEDVDLGTAD 1091
++ PP+++ + G ED+ +K+SD+GGGIPRS ++F Y+YSTA P + D+
Sbjct: 270 NNDTLPPLKVAICKGKEDICVKISDQGGGIPRSQTDQLFKYMYSTAPQPSKSDLH----- 324
Query: 1092 VPITMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLGDSQEPL 1247
+ +AGYGYGLPISRLYARYF GD+ ++S EG+GTDA ++L L D L
Sbjct: 325 -TVPLAGYGYGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLKALSDEANEL 375
>sp|Q9P6P9|PDK_SCHPO [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial
OS=Schizosaccharomyces pombe GN=SPAC644.11c PE=2 SV=1
Length = 425
Score = 238 bits (606), Expect = 1e-061
Identities = 126/261 (48%), Positives = 180/261 (68%), Gaps = 7/261 (2%)
Frame = +3
Query: 477 FTQMIKAVKVRHNNVVPMMALGVNQLKKGMRLYENLDEIHQFLDRFYLSRIGIRMLIGQH 656
F ++ ++ RH+NV +AL + + ++ +N I FLDRFY+SRIGIRML+GQ+
Sbjct: 167 FAYLLNTIRTRHDNVAVEIALDIQEYRRKTNQIDN--SIQIFLDRFYMSRIGIRMLLGQY 224
Query: 657 VELHNPNPPLHTVGYIHTKMSPMEVARNASEDARSICFREYG--SAPEINIYGDPSFTFP 830
+ L + P + VG I T+ + ++ A+E+A+ IC YG APEI I DPS
Sbjct: 225 IALVSEPPRENYVGVISTRANIYQIIEGAAENAKYICRLAYGLFEAPEIQIICDPSLEMM 284
Query: 831 YVPTHLHLMVYELVKNSLRA-VQERFVDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPR 1007
YV +HL+ V+E++KNSLRA V+ VDSD PPI++IVA G ED+TIK+SDEGGGI R
Sbjct: 285 YVESHLNHAVFEILKNSLRATVEFHGVDSD-FFPPIKVIVAKGQEDITIKISDEGGGISR 343
Query: 1008 SGLPKIFTYLYSTARNPLEEDV-DLGTADVPITMAGYGYGLPISRLYARYFGGDLQIISM 1184
+P +++Y+++TA L +D D+ +A+ MAG+G+GLP++RLY RYFGGDL++ISM
Sbjct: 344 RNIPLVWSYMFTTASPTLTDDPHDIVSANSTTPMAGFGFGLPLARLYTRYFGGDLELISM 403
Query: 1185 EGYGTDAYLHLSRLGDSQEPL 1247
EGYGTD Y+HL+RL +S EPL
Sbjct: 404 EGYGTDVYIHLNRLCESAEPL 424
>sp|Q15119|PDK2_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2,
mitochondrial OS=Homo sapiens GN=PDK2 PE=1 SV=2
Length = 407
Score = 237 bits (604), Expect = 2e-061
Identities = 148/355 (41%), Positives = 211/355 (59%), Gaps = 29/355 (8%)
Frame = +3
Query: 234 VSLRYMMEFGSTPTERNLLISAQFLHKELPIRIARRAIELETLPYGLSEKPAVLKVRDWY 413
+S++ ++FGS+ S FL +ELP+R+A E+ LP + P+V V+ WY
Sbjct: 31 LSMKQFLDFGSSNACEK--TSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWY 88
Query: 414 VESFRDMRAFPEIKDTADEK---EFTQMIKAVKVRHNNVVPMMALGVNQLKK--GMRLYE 578
V+S D+ F + KD D + +FT + ++ RHN+VVP MA GV + K G
Sbjct: 89 VQSLLDIMEFLD-KDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVS 147
Query: 579 NLDEIHQFLDRFYLSRIGIRMLIGQHVELH----NPNPPLHTVGYIHTKMSPMEVARNAS 746
N I FLDRFYLSRI IRMLI QH + NP P H +G I + EV ++A
Sbjct: 148 N-QNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKH-IGSIDPNCNVSEVVKDAY 205
Query: 747 EDARSICFREYGSAPEINIY------GDPSFTFPYVPTHLHLMVYELVKNSLRAVQERFV 908
+ A+ +C + Y ++P++ I YVP+HL+ M++EL KN++RA E
Sbjct: 206 DMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESH- 264
Query: 909 DSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTARNPLEEDVDLGTA 1088
+S + PPI+++VA G ED++IK+SD GGG+P + ++F+Y+YSTA P GT
Sbjct: 265 ESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTP-----QPGTG 319
Query: 1089 DVPITMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLG-DSQEPLP 1250
P +AG+GYGLPISRLYA+YF GDLQ+ SMEG+GTDA ++L L DS E LP
Sbjct: 320 GTP--LAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLP 372
>sp|Q64536|PDK2_RAT [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2,
mitochondrial OS=Rattus norvegicus GN=Pdk2 PE=1 SV=1
Length = 407
Score = 237 bits (603), Expect = 2e-061
Identities = 151/355 (42%), Positives = 213/355 (60%), Gaps = 29/355 (8%)
Frame = +3
Query: 234 VSLRYMMEFGSTPTERNLLISAQFLHKELPIRIARRAIELETLPYGLSEKPAVLKVRDWY 413
+S++ ++FGS+ S FL +ELP+R+A E+ LP + P+V V+ WY
Sbjct: 31 LSMKQFLDFGSSNACEK--TSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWY 88
Query: 414 VESFRDMRAFPEIKDTADEK---EFTQMIKAVKVRHNNVVPMMALGVNQLKK--GMRLYE 578
V+S D+ F + KD D + +FT + ++ RHN+VVP MA GV + K G
Sbjct: 89 VQSLLDIMEFLD-KDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVS 147
Query: 579 NLDEIHQFLDRFYLSRIGIRMLIGQHVELH----NPNPPLHTVGYIHTKMSPMEVARNAS 746
N I FLDRFYLSRI IRMLI QH + NP P H +G I S +V ++A
Sbjct: 148 N-QNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKH-IGSIDPNCSVSDVVKDAY 205
Query: 747 EDARSICFREYGSAPEINI--YGDPSFTFP----YVPTHLHLMVYELVKNSLRAVQERFV 908
+ A+ +C + Y ++P++ I + T P YVP+HL+ M++EL KN++RA E
Sbjct: 206 DMAKLLCDKYYMASPDLEIQEVNATNATQPIHMVYVPSHLYHMLFELFKNAMRATVESH- 264
Query: 909 DSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTARNPLEEDVDLGTA 1088
+S PPI+I+VA G ED++IK+SD GGG+P + ++F+Y+YSTA P GT
Sbjct: 265 ESSLTLPPIKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTP-----QPGTG 319
Query: 1089 DVPITMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLG-DSQEPLP 1250
P +AG+GYGLPISRLYA+YF GDLQ+ SMEG+GTDA ++L L DS E LP
Sbjct: 320 GTP--LAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLP 372
>sp|Q9JK42|PDK2_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2,
mitochondrial OS=Mus musculus GN=Pdk2 PE=1 SV=1
Length = 407
Score = 236 bits (602), Expect = 3e-061
Identities = 149/355 (41%), Positives = 211/355 (59%), Gaps = 29/355 (8%)
Frame = +3
Query: 234 VSLRYMMEFGSTPTERNLLISAQFLHKELPIRIARRAIELETLPYGLSEKPAVLKVRDWY 413
+S++ ++FGS+ S FL +ELP+R+A E+ LP + P+V V+ WY
Sbjct: 31 LSMKQFLDFGSSNACEK--TSFTFLRQELPVRLANIMKEINLLPDRVLGTPSVQLVQSWY 88
Query: 414 VESFRDMRAFPEIKDTADEK---EFTQMIKAVKVRHNNVVPMMALGVNQLKK--GMRLYE 578
V+S D+ F + KD D + +FT + ++ RHN+VVP MA GV + K G
Sbjct: 89 VQSLLDIMEFLD-KDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVS 147
Query: 579 NLDEIHQFLDRFYLSRIGIRMLIGQHVELH----NPNPPLHTVGYIHTKMSPMEVARNAS 746
N I FLDRFYLSRI IRMLI QH + NP P H +G I S +V ++A
Sbjct: 148 N-QNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKH-IGSIDPNCSVSDVVKDAY 205
Query: 747 EDARSICFREYGSAPEINIY------GDPSFTFPYVPTHLHLMVYELVKNSLRAVQERFV 908
+ A+ +C + Y ++P++ I + YVP+HL+ M++EL KN++RA E
Sbjct: 206 DMAKLLCDKYYMASPDLEIQEVNATNANQPIHMVYVPSHLYHMLFELFKNAMRATVESH- 264
Query: 909 DSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTARNPLEEDVDLGTA 1088
+S PPI+I+VA G ED++IK+SD GGG+P + ++F+Y+YSTA P GT
Sbjct: 265 ESSLTLPPIKIMVALGEEDLSIKMSDRGGGVPLRRIERLFSYMYSTAPTP-----QPGTG 319
Query: 1089 DVPITMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLG-DSQEPLP 1250
P +AG+GYGLPISRLYA+YF GDLQ+ SMEG+GTDA ++L L DS E LP
Sbjct: 320 GTP--LAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLP 372
>sp|Q8BFP9|PDK1_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1,
mitochondrial OS=Mus musculus GN=Pdk1 PE=2 SV=1
Length = 434
Score = 235 bits (597), Expect = 1e-060
Identities = 141/353 (39%), Positives = 206/353 (58%), Gaps = 24/353 (6%)
Frame = +3
Query: 234 VSLRYMMEFGSTPTERNLLISAQFLHKELPIRIARRAIELETLPYGLSEKPAVLKVRDWY 413
+S++ ++FGS S FL +ELP+R+A E+ LP L P+V V+ WY
Sbjct: 57 LSMKQFLDFGSVNACEK--TSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWY 114
Query: 414 VESFRDMRAFPEIKDTADEK---EFTQMIKAVKVRHNNVVPMMALGVNQLKKGMRLYE-N 581
++S +++ F + K D K EFT + ++ RHN+V+P MA GV + K+ +
Sbjct: 115 IQSLQELLDFKD-KSAEDAKTIYEFTDTVIRIRNRHNDVIPTMAQGVTEYKESFGVDPVT 173
Query: 582 LDEIHQFLDRFYLSRIGIRMLIGQHVELH-NPNPPLHT--VGYIHTKMSPMEVARNASED 752
+ FLDRFY+SRI IRML+ QH L P H +G I+ +EV ++ E+
Sbjct: 174 SQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGSPSHRKHIGSINPNCDVVEVIKDGYEN 233
Query: 753 ARSICFREYGSAPEINI----YGDPSFTFP--YVPTHLHLMVYELVKNSLRAVQERFVDS 914
AR +C Y ++PE+ + P T YVP+HL+ MV+EL KN++RA E D
Sbjct: 234 ARRLCDLYYVNSPELELEELNAKSPGQTIQVVYVPSHLYHMVFELFKNAMRATMEHHADK 293
Query: 915 DRVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTARNPLEEDVDLGTADV 1094
V PPI++ V G ED+T+K+SD GGG+P S + ++F Y+YSTA P E
Sbjct: 294 G-VYPPIQVHVTLGEEDLTVKMSDRGGGVPLSKIDRLFNYMYSTAPRPRVE------TSR 346
Query: 1095 PITMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLG-DSQEPLP 1250
+ +AG+GYGLPISRLYA+YF GDL++ S+EGYGTDA +++ L +S E LP
Sbjct: 347 AVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESVERLP 399
>sp|Q63065|PDK1_RAT [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1,
mitochondrial OS=Rattus norvegicus GN=Pdk1 PE=1 SV=1
Length = 434
Score = 233 bits (592), Expect = 4e-060
Identities = 140/354 (39%), Positives = 205/354 (57%), Gaps = 26/354 (7%)
Frame = +3
Query: 234 VSLRYMMEFGSTPTERNLLISAQFLHKELPIRIARRAIELETLPYGLSEKPAVLKVRDWY 413
+S++ ++FGS S FL +ELP+R+A E+ LP L P+V V+ WY
Sbjct: 57 LSMKQFLDFGSVNACEK--TSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWY 114
Query: 414 VESFRDMRAFPEIKDTADEK---EFTQMIKAVKVRHNNVVPMMALGVNQLKKGMRLYE-N 581
++S +++ F + K D K EFT + ++ RHN+V+P MA GV + K+ +
Sbjct: 115 IQSLQELLDFKD-KSAEDAKTIYEFTDTVIRIRNRHNDVIPTMAQGVTEYKESFGVDPVT 173
Query: 582 LDEIHQFLDRFYLSRIGIRMLIGQHVELH-NPNPPLHT--VGYIHTKMSPMEVARNASED 752
+ FLDRFY+SRI IRML+ QH L P H +G I+ +EV ++ E+
Sbjct: 174 SQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGSPSHRKHIGSINPNCDVVEVIKDGYEN 233
Query: 753 ARSICFREYGSAPEINIY-------GDPSFTFPYVPTHLHLMVYELVKNSLRAVQERFVD 911
AR +C Y ++PE+ + G P YVP+HL+ MV+EL KN++RA E D
Sbjct: 234 ARRLCDLYYVNSPELELEELNAKSPGQP-IQVVYVPSHLYHMVFELFKNAMRATMEHHAD 292
Query: 912 SDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTARNPLEEDVDLGTAD 1091
V PPI++ V G ED+T+K+SD GGG+P + ++F Y+YSTA P E
Sbjct: 293 KG-VYPPIQVHVTLGEEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVE------TS 345
Query: 1092 VPITMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLG-DSQEPLP 1250
+ +AG+GYGLPISRLYA+YF GDL++ S+EGYGTDA +++ L +S E LP
Sbjct: 346 RAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESIERLP 399
>sp|Q15118|PDK1_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1,
mitochondrial OS=Homo sapiens GN=PDK1 PE=1 SV=1
Length = 436
Score = 229 bits (583), Expect = 5e-059
Identities = 139/356 (39%), Positives = 206/356 (57%), Gaps = 28/356 (7%)
Frame = +3
Query: 234 VSLRYMMEFGSTPTERNLLISAQFLHKELPIRIARRAIELETLPYGLSEKPAVLKVRDWY 413
+S++ ++FGS S FL +ELP+R+A E+ LP L P+V V+ WY
Sbjct: 57 LSMKQFLDFGSVNACEK--TSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWY 114
Query: 414 VESFRDMRAFPEIKDTADEK---EFTQMIKAVKVRHNNVVPMMALGVNQLKKGMRLYE-N 581
++S +++ F + K D K +FT + ++ RHN+V+P MA GV + K+ +
Sbjct: 115 IQSLQELLDFKD-KSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVT 173
Query: 582 LDEIHQFLDRFYLSRIGIRMLIGQHVEL---HNPNPPLHT--VGYIHTKMSPMEVARNAS 746
+ FLDRFY+SRI IRML+ QH L P H +G I+ + +EV ++
Sbjct: 174 SQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGY 233
Query: 747 EDARSICFREYGSAPEINIY-------GDPSFTFPYVPTHLHLMVYELVKNSLRAVQERF 905
E+AR +C Y ++PE+ + G P YVP+HL+ MV+EL KN++RA E
Sbjct: 234 ENARRLCDLYYINSPELELEELNAKSPGQP-IQVVYVPSHLYHMVFELFKNAMRATMEHH 292
Query: 906 VDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTARNPLEEDVDLGT 1085
+ V PPI++ V G ED+T+K+SD GGG+P + ++F Y+YSTA P E
Sbjct: 293 ANRG-VYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVE------ 345
Query: 1086 ADVPITMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLG-DSQEPLP 1250
+ +AG+GYGLPISRLYA+YF GDL++ S+EGYGTDA +++ L DS E LP
Sbjct: 346 TSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLP 401
>sp|Q15120|PDK3_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3,
mitochondrial OS=Homo sapiens GN=PDK3 PE=1 SV=1
Length = 406
Score = 226 bits (575), Expect = 4e-058
Identities = 145/369 (39%), Positives = 207/369 (56%), Gaps = 29/369 (7%)
Frame = +3
Query: 195 EDVHRWGCMKQTGVSLRYMMEFG-STPTERNLLISAQFLHKELPIRIARRAIELETLPYG 371
+ + R+ + +S++ ++FG E+ S FL KELP+R+A E+ LP
Sbjct: 14 KQIERYSRFSPSPLSIKQFLDFGRDNACEKT---SYMFLRKELPVRLANTMREVNLLPDN 70
Query: 372 LSEKPAVLKVRDWYVESFRDMRAF----PEIKDTADEKEFTQMIKAVKVRHNNVVPMMAL 539
L +P+V V+ WY++SF ++ + PE D F Q++ V+ RHN+VVP MA
Sbjct: 71 LLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLD--NFLQVLIKVRNRHNDVVPTMAQ 128
Query: 540 GVNQLKKGMRLYENLD-EIHQFLDRFYLSRIGIRMLIGQHVELH----NPNPPLHTVGYI 704
GV + K+ + I FLDRFY +RI RMLI QH L NP P H +G I
Sbjct: 129 GVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVHPKH-IGSI 187
Query: 705 HTKMSPMEVARNASEDARSICFREYGSAPEINI------YGDPSFTFPYVPTHLHLMVYE 866
+ +V ++A E A+ +C + Y APE+ + D YVP+HL M++E
Sbjct: 188 DPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFE 247
Query: 867 LVKNSLRAVQERFVDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYST 1046
L KNS+RA E + D P ++ +V G ED++IK+SD GGG+P + ++F Y+YST
Sbjct: 248 LFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYST 307
Query: 1047 ARNPLEEDVDLGTADVPITMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRL 1226
A P E T P +AG+GYGLPISRLYARYF GDL++ SMEG GTDA ++L L
Sbjct: 308 APRPSLEP----TRAAP--LAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKAL 361
Query: 1227 -GDSQEPLP 1250
+S E LP
Sbjct: 362 SSESFERLP 370
>sp|O70571|PDK4_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4,
mitochondrial OS=Mus musculus GN=Pdk4 PE=2 SV=1
Length = 412
Score = 226 bits (575), Expect = 4e-058
Identities = 147/399 (36%), Positives = 228/399 (57%), Gaps = 35/399 (8%)
Frame = +3
Query: 156 VKKASEMFSKSLI-EDVHRWGCMKQTGVSLRYMMEFGS-TPTERNLLISAQFLHKELPIR 329
++ AS + S SL+ +V + + +S++ +++FGS ER S FL +ELP+R
Sbjct: 8 MRSASSLSSASLVPREVELFSRYSPSPLSMKQLLDFGSENACERT---SFAFLRQELPVR 64
Query: 330 IARRAIELETLPYGLSEKPAVLKVRDWYVESFRDMRAFPEIKDTADEK---EFTQMIKAV 500
+A E++ LP L P+V V+ WY++S D+ F E K D+K EF + V
Sbjct: 65 LANILKEIDILPDRLVNTPSVQLVKSWYIQSLMDLVEFHE-KSPEDQKALSEFVDTLVKV 123
Query: 501 KVRHNNVVPMMALGVNQLKKGMRLYENLDE-IHQFLDRFYLSRIGIRMLIGQHVELHNPN 677
+ RH+NVVP MA G+ + K + ++ + FLDRFY++RI RML+ QH+ + + +
Sbjct: 124 RNRHHNVVPTMAQGILEYKDTCTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDS 183
Query: 678 P---PLHTVGYIHTKMSPMEVARNASEDARSICFREYGSAPEINI------YGDPSFTFP 830
P H +G I + V ++A E A+ +C + Y ++PE+N+ +
Sbjct: 184 KTGNPSH-IGSIDPNCDVVAVVQDAFECAKMLCDQYYLTSPELNLTQVNGKFPGQPIHIV 242
Query: 831 YVPTHLHLMVYELVKNSLRAVQERFVDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRS 1010
YVP+HLH M++EL KN++RA E + + P+ V G ED+TIK+SD GGG+P
Sbjct: 243 YVPSHLHHMLFELFKNAMRATVEHQENRPSLT-PVEATVVLGKEDLTIKISDRGGGVPLR 301
Query: 1011 GLPKIFTYLYSTARNPLEEDVDLGTADVPITMAGYGYGLPISRLYARYFGGDLQIISMEG 1190
++F+Y YSTA P+ ++ + + P +AG+GYGLPISRLYA+YF GDL + SM G
Sbjct: 302 ITDRLFSYTYSTAPTPVMDN----SRNAP--LAGFGYGLPISRLYAKYFQGDLNLYSMSG 355
Query: 1191 YGTDAYLHLSRL-GDSQEPLP-------*EYHLSSQASE 1283
YGTDA ++L L +S E LP Y +SS+A +
Sbjct: 356 YGTDAIIYLKALSSESVEKLPVFNKSAFKHYQMSSEADD 394
>sp|Q16654|PDK4_HUMAN [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4,
mitochondrial OS=Homo sapiens GN=PDK4 PE=1 SV=1
Length = 411
Score = 223 bits (568), Expect = 3e-057
Identities = 142/384 (36%), Positives = 221/384 (57%), Gaps = 34/384 (8%)
Frame = +3
Query: 198 DVHRWGCMKQTGVSLRYMMEFGS-TPTERNLLISAQFLHKELPIRIARRAIELETLPYGL 374
+V + + +S++ +++FGS ER S FL +ELP+R+A E++ LP L
Sbjct: 23 EVEHFSRYSPSPLSMKQLLDFGSENACERT---SFAFLRQELPVRLANILKEIDILPTQL 79
Query: 375 SEKPAVLKVRDWYVESFRDMRAFPEIKDTADEK---EFTQMIKAVKVRHNNVVPMMALGV 545
+V V+ WY++S D+ F E K D+K +F + V+ RH+NVVP MA G+
Sbjct: 80 VNTSSVQLVKSWYIQSLMDLVEFHE-KSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGI 138
Query: 546 NQLKKGMRLYENLDE-IHQFLDRFYLSRIGIRMLIGQHVELHNPNP---PLHTVGYIHTK 713
+ K + ++ + FLDRFY++RI RML+ QH+ + + + P H +G I
Sbjct: 139 IEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSH-IGSIDPN 197
Query: 714 MSPMEVARNASEDARSICFREYGSAPEINI------YGDPSFTFPYVPTHLHLMVYELVK 875
+ V ++A E +R +C + Y S+PE+ + + D YVP+HLH M++EL K
Sbjct: 198 CDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFK 257
Query: 876 NSLRAVQERFVDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTARN 1055
N++RA E ++ PI +IV G ED+TIK+SD GGG+P + ++F+Y YSTA
Sbjct: 258 NAMRATVEH-QENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPT 316
Query: 1056 PLEEDVDLGTADVPITMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRL-GD 1232
P+ ++ + + P +AG+GYGLPISRLYA+YF GDL + S+ GYGTDA ++L L +
Sbjct: 317 PVMDN----SRNAP--LAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSE 370
Query: 1233 SQEPLP-------*EYHLSSQASE 1283
S E LP Y +SS+A +
Sbjct: 371 SIEKLPVFNKSAFKHYQMSSEADD 394
>sp|O88345|PDK4_SPETR [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4,
mitochondrial OS=Spermophilus tridecemlineatus GN=PDK4 PE=2 SV=1
Length = 412
Score = 223 bits (567), Expect = 3e-057
Identities = 144/400 (36%), Positives = 230/400 (57%), Gaps = 35/400 (8%)
Frame = +3
Query: 153 AVKKASEMFSKSLI-EDVHRWGCMKQTGVSLRYMMEFGS-TPTERNLLISAQFLHKELPI 326
A+ A + S L+ +V + + +S++ +++FGS ER S FL +ELP+
Sbjct: 7 AMHSARSLSSVGLVPREVELFSRYSPSPLSMKQLLDFGSDNACERT---SFSFLRQELPV 63
Query: 327 RIARRAIELETLPYGLSEKPAVLKVRDWYVESFRDMRAFPEIKDTADEK---EFTQMIKA 497
R+A E++ LP L+ +V V+ WY++S ++ F E K D+K +F +
Sbjct: 64 RLANILKEIDVLPDRLTNTSSVQLVKSWYIQSLMELVEFHE-KSPEDQKNLSDFVDTLIK 122
Query: 498 VKVRHNNVVPMMALGVNQLKKGMRLYENLDE-IHQFLDRFYLSRIGIRMLIGQHVELHNP 674
V+ RH+NVVP MA G+ + K + ++ + FLDRFY++RI RML+ QH+ + +
Sbjct: 123 VRNRHHNVVPTMAQGILEYKDTCTVDPVTNQSLQYFLDRFYMNRISTRMLMNQHILIFSD 182
Query: 675 NP---PLHTVGYIHTKMSPMEVARNASEDARSICFREYGSAPEINI------YGDPSFTF 827
+ P H +G I K + V ++A E ++ +C + Y ++PE+ + +
Sbjct: 183 SQTGNPSH-IGSIDPKCDVVAVIQDAFESSKMLCDQYYLTSPELKLTQVNGKFPGQPIHI 241
Query: 828 PYVPTHLHLMVYELVKNSLRAVQERFVDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPR 1007
YVP+HLH M++EL KN++RA ER +S P+ +IV G ED+TIK+SD GGG+P
Sbjct: 242 VYVPSHLHHMLFELFKNAMRATVER-QESWPSLTPVEVIVVLGKEDLTIKISDRGGGVPL 300
Query: 1008 SGLPKIFTYLYSTARNPLEEDVDLGTADVPITMAGYGYGLPISRLYARYFGGDLQIISME 1187
++F+Y+YSTA P+ ++ + + P +AG+GYGLPISRLYA+YF GDL + S+
Sbjct: 301 RITDRLFSYMYSTAPTPVMDN----SRNAP--LAGFGYGLPISRLYAKYFQGDLNLYSLS 354
Query: 1188 GYGTDAYLHLSRL-GDSQEPLP-------*EYHLSSQASE 1283
GYGTDA ++L L +S E LP Y +SS+A +
Sbjct: 355 GYGTDAIIYLKALSSESVEKLPVFNKSAFKHYQMSSEADD 394
>sp|Q922H2|PDK3_MOUSE [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3,
mitochondrial OS=Mus musculus GN=Pdk3 PE=2 SV=1
Length = 415
Score = 221 bits (562), Expect = 1e-056
Identities = 142/368 (38%), Positives = 206/368 (55%), Gaps = 27/368 (7%)
Frame = +3
Query: 195 EDVHRWGCMKQTGVSLRYMMEFG-STPTERNLLISAQFLHKELPIRIARRAIELETLPYG 371
+ + R+ + +S++ ++FG E+ S FL KELP+R+A E+ LP
Sbjct: 14 KQIERYSRFSPSPLSIKQFLDFGRDNACEKT---SYMFLRKELPVRLANTMREVNLLPDN 70
Query: 372 LSEKPAVLKVRDWYVESFRDMRAFPEIKDTADEK---EFTQMIKAVKVRHNNVVPMMALG 542
L +P+V V+ WY++SF ++ + E K D + F ++ ++ RHN+VVP MA G
Sbjct: 71 LLNRPSVGLVQSWYMQSFLELLEY-ENKSPEDPRVLDNFLNVLINIRNRHNDVVPTMAQG 129
Query: 543 VNQLKKGMRLYENL-DEIHQFLDRFYLSRIGIRMLIGQHVELH----NPNPPLHTVGYIH 707
V + K+ + I FLDRFY +RI RMLI QH L NP P H +G I
Sbjct: 130 VIEYKEKFGFDPFISSNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPAHPKH-IGSID 188
Query: 708 TKMSPMEVARNASEDARSICFREYGSAPEINI------YGDPSFTFPYVPTHLHLMVYEL 869
+ +V ++A E A+ +C + Y APE+ + + YVP+HL M++EL
Sbjct: 189 PTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPNKPIQVVYVPSHLFHMLFEL 248
Query: 870 VKNSLRAVQERFVDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTYLYSTA 1049
KNS+RA E D P ++ +V G ED++IK+SD GGG+P + ++F Y+YSTA
Sbjct: 249 FKNSMRATVELHEDKKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYSTA 308
Query: 1050 RNPLEEDVDLGTADVPITMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRL- 1226
P E T P +AG+GYGLPISRLYARYF GDL++ SMEG GTDA ++L L
Sbjct: 309 PRPSLEP----TRAAP--LAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALS 362
Query: 1227 GDSQEPLP 1250
+S E LP
Sbjct: 363 SESFERLP 370
>sp|O54937|PDK4_RAT [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4,
mitochondrial OS=Rattus norvegicus GN=Pdk4 PE=2 SV=1
Length = 412
Score = 220 bits (560), Expect = 2e-056
Identities = 143/399 (35%), Positives = 225/399 (56%), Gaps = 35/399 (8%)
Frame = +3
Query: 156 VKKASEMFSKSLI-EDVHRWGCMKQTGVSLRYMMEFGS-TPTERNLLISAQFLHKELPIR 329
++ AS + + L+ +V + + +S++ +++FGS ER S FL +ELP+R
Sbjct: 8 MRSASSLGNAGLVPREVELFSRYSPSPLSMKQLLDFGSENACERT---SFSFLRQELPVR 64
Query: 330 IARRAIELETLPYGLSEKPAVLKVRDWYVESFRDMRAFPEIKDTADEK---EFTQMIKAV 500
+A E++ LP L P+V V+ WY++S D+ F E K D+K +F + V
Sbjct: 65 LANILKEIDILPEHLVNTPSVQLVKSWYIQSLMDLVEFHE-KSPEDQKVLSDFVDTLVKV 123
Query: 501 KVRHNNVVPMMALGVNQLKKGMRLYENLDE-IHQFLDRFYLSRIGIRMLIGQHVELHNPN 677
+ RH+NVVP MA G+ + K + ++ + FLDRFY++RI RML+ QH+ + + +
Sbjct: 124 RNRHHNVVPTMAQGILEYKDNCTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDS 183
Query: 678 P---PLHTVGYIHTKMSPMEVARNASEDARSICFREYGSAPEINI------YGDPSFTFP 830
P H +G I + V +A E A+ +C + Y ++PE+ + +
Sbjct: 184 KTGNPSH-IGSIDPNCDVVAVVEDAFECAKMLCDQYYLTSPELKLTQVNGKFPGQPIHIV 242
Query: 831 YVPTHLHLMVYELVKNSLRAVQERFVDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRS 1010
YVP+HLH M++EL KN++RA E ++ P+ V G ED+TIK+SD GGG+P
Sbjct: 243 YVPSHLHHMLFELFKNAMRATVEH-QENRPFLTPVEATVVLGKEDLTIKISDRGGGVPLR 301
Query: 1011 GLPKIFTYLYSTARNPLEEDVDLGTADVPITMAGYGYGLPISRLYARYFGGDLQIISMEG 1190
++F+Y YSTA P+ ++ + + P +AG+GYGLPISRLYA+YF GDL + SM G
Sbjct: 302 ITDRLFSYTYSTAPTPVMDN----SRNAP--LAGFGYGLPISRLYAKYFQGDLNLYSMSG 355
Query: 1191 YGTDAYLHLSRL-GDSQEPLP-------*EYHLSSQASE 1283
YGTDA ++L L +S E LP Y +SS+A +
Sbjct: 356 YGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADD 394
>sp|Q1KMR4|PDK4_RHIFE [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4,
mitochondrial OS=Rhinolophus ferrumequinum GN=PDK4 PE=2 SV=1
Length = 412
Score = 218 bits (553), Expect = 1e-055
Identities = 137/382 (35%), Positives = 223/382 (58%), Gaps = 30/382 (7%)
Frame = +3
Query: 156 VKKASEMFSKSLI-EDVHRWGCMKQTGVSLRYMMEFGS-TPTERNLLISAQFLHKELPIR 329
++ A + S L+ +V + + +S++ +++FGS ER S+ FL +ELP+R
Sbjct: 8 MRSARSLSSAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERT---SSAFLRQELPVR 64
Query: 330 IARRAIELETLPYGLSEKPAVLKVRDWYVESFRDMRAFPEIKDTADEK---EFTQMIKAV 500
+A E++ LP L +V V+ WY++S ++ F E + D+K +F + V
Sbjct: 65 LANILKEIDILPDRLVNTSSVQLVKSWYIQSLMELVEFHE-RSPDDQKVLSDFVDTLITV 123
Query: 501 KVRHNNVVPMMALGVNQLKKGMRLYENLDE-IHQFLDRFYLSRIGIRMLIGQHVELHNPN 677
+ RH+NVVP MA G+ + K + ++ + FLDRFY++RI RML+ QH+ + + +
Sbjct: 124 RNRHHNVVPTMAQGIIEYKDSCTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDS 183
Query: 678 P---PLHTVGYIHTKMSPMEVARNASEDARSICFREYGSAPEINIY-------GDPSFTF 827
P H +G I + V ++A E +R +C + Y ++PE+ + G+P
Sbjct: 184 QTGNPSH-IGSIDPNCNVAAVVQDAFECSRMLCDQYYLTSPELKLTQVNGKFPGEP-IHI 241
Query: 828 PYVPTHLHLMVYELVKNSLRAVQERFVDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPR 1007
YVP+HLH M++EL KN++RA E +++ P+ + V G ED+TIK+SD GGG+P
Sbjct: 242 VYVPSHLHHMLFELFKNAMRATVEH-QENEPSLTPVEVTVVLGKEDLTIKISDRGGGVPL 300
Query: 1008 SGLPKIFTYLYSTARNPLEEDVDLGTADVPITMAGYGYGLPISRLYARYFGGDLQIISME 1187
++F+Y+YSTA P+ ++ + + P +AG+GYGLPISRLYA+YF GDL + S+
Sbjct: 301 RITDRLFSYMYSTAPTPVMDN----SRNAP--LAGFGYGLPISRLYAKYFQGDLHLYSLS 354
Query: 1188 GYGTDAYLHLSRL-GDSQEPLP 1250
GYGTDA ++L L +S E LP
Sbjct: 355 GYGTDAIIYLKALSSESVEKLP 376
>sp|O02623|PDK_ASCSU [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial
OS=Ascaris suum PE=2 SV=1
Length = 399
Score = 216 bits (549), Expect = 4e-055
Identities = 138/374 (36%), Positives = 211/374 (56%), Gaps = 32/374 (8%)
Frame = +3
Query: 177 FSKSLIEDVHRWGCMKQTGVSLRYMMEFGSTPTERNLLISAQFLHKELPIRIARRAIELE 356
F+ ++ + + + + ++++ ++FG T T ++ S FL EL +R+A E+
Sbjct: 11 FTSAIARKLEHYSQFQPSSLTIQQYLDFGQTGTMKS---SFLFLKNELLVRLANIMQEIS 67
Query: 357 TLPYGLSEKPAVLKVRDWYVESFRDMRAFPEIKDTAD-EKEFTQMIKAVKVRHNNVVPMM 533
LP L + P+ V +WY ESF D+ F + D +F ++ + RH+ VV M
Sbjct: 68 LLPPTLLKMPSRRLVSNWYCESFEDLLQFEHAQVEPDIMSKFNDQLQTILKRHSRVVETM 127
Query: 534 ALGVNQLKKGMRLYENLD-----EIHQFLDRFYLSRIGIRMLIGQHVELHN---PNPPLH 689
A G+ +L++ E +D I FLDRFY++RI IRML QH+ + P P H
Sbjct: 128 AEGLIELRES----EGVDIASERGIQYFLDRFYINRISIRMLQNQHLVVFGVVLPESPRH 183
Query: 690 TVGYIHTKMSPMEVARNASEDARSICFREYGSAPEINIYGDPS------FTFPYVPTHLH 851
+G I V +A E+AR +C R Y +AP + + S + VP+HL+
Sbjct: 184 -IGCIDPGCDVESVVHDAYENARFLCERYYLTAPGMKLEMHNSVNPGMPISIVAVPSHLY 242
Query: 852 LMVYELVKNSLRAVQERFVDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFT 1031
+++EL KNS+RA E +D PPI+++V G ED++IK+SD GGG+ R+ L ++FT
Sbjct: 243 HIMFELFKNSMRATVENH-GADEDLPPIKVMVVRGAEDLSIKISDRGGGVSRTILDRLFT 301
Query: 1032 YLYSTARNPLEEDVDLGTADVPITMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYL 1211
Y+YSTA P + GT +AGYGYGLP+SRLYARYF GD+ ++SMEGYGTDA +
Sbjct: 302 YMYSTAPPPPRD----GTQP---PLAGYGYGLPLSRLYARYFHGDMYLVSMEGYGTDAMI 354
Query: 1212 HLSRLG-DSQEPLP 1250
L + ++ E LP
Sbjct: 355 FLKAIPVEASEVLP 368
>sp|Q02332|PDHK2_CAEEL Probable [pyruvate dehydrogenase [lipoamide]] kinase,
mitochondrial OS=Caenorhabditis elegans GN=pdhk-2 PE=2 SV=1
Length = 401
Score = 203 bits (516), Expect = 3e-051
Identities = 140/373 (37%), Positives = 209/373 (56%), Gaps = 30/373 (8%)
Frame = +3
Query: 177 FSKSLIEDVHRWGCMKQTGVSLRYMMEFGSTPTERNLLISAQFLHKELPIRIARRAIELE 356
F SL + + + + + ++++ ++FG T N S FL EL +R+A E
Sbjct: 11 FVGSLAKKLDYYSQFQPSSLTIQQYLDFGRIGTSAN---SYTFLKNELLVRLANIMQEFT 67
Query: 357 TLPYGLSEKPAVLKVRDWYVESFRDMRAFPEIKDTADEK--EFTQMIKAVKVRHNNVVPM 530
LP L + P+ V +WY ESF D+ F E D++ E+ F + V RH +VV
Sbjct: 68 LLPPKLLQMPSSKMVSNWYAESFEDLLLF-EASDSSPEQVARFNDQLTVVLKRHAHVVET 126
Query: 531 MALGVNQLKKGMRL-YENLDEIHQFLDRFYLSRIGIRMLIGQHVELHN---PNPPLHTVG 698
MA G+ +L++ + + I FLDRFY++RI IRML QH+ + P P H VG
Sbjct: 127 MAEGLIELRESDGVDIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGNVLPESPRH-VG 185
Query: 699 YIHTKMSPMEVARNASEDARSICFREYGSAPEINI-------YGDPSFTFPYVPTHLHLM 857
I V +A E+AR +C R Y ++P + + G P + VP+HL+ M
Sbjct: 186 CIDPACDVESVVYDAFENARFLCDRYYLTSPSMKLEMHNAVEKGKP-ISIVAVPSHLYHM 244
Query: 858 VYELVKNSLRA-VQERFVDSDRVAPPIRIIVADGIEDVTIKVSDEGGGIPRSGLPKIFTY 1034
++EL KN++RA V+ VD D P I++ V G ED++IK+ D GGG+ R+ L +++ Y
Sbjct: 245 MFELFKNAMRATVEYHGVDDD--LPDIKVYVVKGQEDLSIKICDRGGGVSRTILERLYNY 302
Query: 1035 LYSTARNPLEEDVDLGTADVPITMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLH 1214
+YSTA P + GT +AGYGYGLP+SRLYARYF GDL ++SMEG+GTDA ++
Sbjct: 303 MYSTAPPPPRD----GT---QAPLAGYGYGLPLSRLYARYFLGDLFLVSMEGHGTDACIY 355
Query: 1215 LSRLG-DSQEPLP 1250
L + ++ E LP
Sbjct: 356 LKAVPVEASEVLP 368
>sp|O14874|BCKD_HUMAN [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]]
kinase, mitochondrial OS=Homo sapiens GN=BCKDK PE=1 SV=2
Length = 412
Score = 175 bits (443), Expect = 8e-043
Identities = 93/267 (34%), Positives = 155/267 (58%), Gaps = 5/267 (1%)
Frame = +3
Query: 249 MMEFGSTPTERNLLISAQFLHKELPIRIARRAIELETLPYGLSEKPAVLKVRDWYVESFR 428
M+ G + +LL SA++L +ELP+RIA R LP+ + P +L V + Y+ +F+
Sbjct: 75 MLYAGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQ 134
Query: 429 DMRAFPEIKDTADEKEFTQMIKAVKVRHNNVVPMMALGVNQLKKGMRLYENLDEIHQFLD 608
+ FP IKD ADE ++ Q+++ + H +VV ++A G+ + +K + E+ + FLD
Sbjct: 135 KLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI---EDEKLVRYFLD 191
Query: 609 RFYLSRIGIRMLIGQHVELHNPNPPLHTVGYIHTKMSPMEVARNASEDARSICFREYGSA 788
+ SR+GIRML H+ LH P VG I T++SP ++ + AR +C +YG+A
Sbjct: 192 KTLTSRLGIRMLATHHLALHEDKPDF--VGIICTRLSPKKIIEKWVDFARRLCEHKYGNA 249
Query: 789 PEINIYGDPSFTFPYVPTHLHLMVYELVKNSLRAVQERFVDSDRVAPPIRIIVADGIEDV 968
P + I G + FP++P L ++ EL+KN++RA E +D+ P + I +A+ D+
Sbjct: 250 PRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDL 309
Query: 969 TIKVSDEGGGIPRSGLPKIFTYLYSTA 1049
I++SD GGGI L ++ Y ++TA
Sbjct: 310 IIRISDRGGGIAHKDLDRVMDYHFTTA 336
>sp|Q2KJG8|BCKD_BOVIN [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]]
kinase, mitochondrial OS=Bos taurus GN=BCKDK PE=2 SV=1
Length = 412
Score = 175 bits (442), Expect = 1e-042
Identities = 93/267 (34%), Positives = 154/267 (57%), Gaps = 5/267 (1%)
Frame = +3
Query: 249 MMEFGSTPTERNLLISAQFLHKELPIRIARRAIELETLPYGLSEKPAVLKVRDWYVESFR 428
M+ G + +LL SA++L +ELP+RIA R +LP+ + P +L V + Y+ +F+
Sbjct: 75 MLYSGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHELYIRAFQ 134
Query: 429 DMRAFPEIKDTADEKEFTQMIKAVKVRHNNVVPMMALGVNQLKKGMRLYENLDEIHQFLD 608
+ FP IKD ADE + Q+++ + H +VV ++A G L++ + E+ + FLD
Sbjct: 135 KLTDFPPIKDQADEARYCQLVRQLLDDHKDVVTLLAEG---LRESRKYIEDEKLVRYFLD 191
Query: 609 RFYLSRIGIRMLIGQHVELHNPNPPLHTVGYIHTKMSPMEVARNASEDARSICFREYGSA 788
+ SR+GIRML H+ LH P VG I T++SP ++ + AR +C +YG+A
Sbjct: 192 KTLTSRLGIRMLATHHLALHEDKPDF--VGIICTRLSPKKIIEKWVDFARRLCEHKYGNA 249
Query: 789 PEINIYGDPSFTFPYVPTHLHLMVYELVKNSLRAVQERFVDSDRVAPPIRIIVADGIEDV 968
P + I G + FP++P L ++ EL+KN++RA E +D+ P + I +A+ D+
Sbjct: 250 PRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDIDL 309
Query: 969 TIKVSDEGGGIPRSGLPKIFTYLYSTA 1049
I++SD GGGI L ++ Y ++TA
Sbjct: 310 VIRISDRGGGIAHKDLDRVMDYHFTTA 336
>sp|Q00972|BCKD_RAT [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase,
mitochondrial OS=Rattus norvegicus GN=Bckdk PE=1 SV=2
Length = 412
Score = 174 bits (441), Expect = 1e-042
Identities = 92/267 (34%), Positives = 155/267 (58%), Gaps = 5/267 (1%)
Frame = +3
Query: 249 MMEFGSTPTERNLLISAQFLHKELPIRIARRAIELETLPYGLSEKPAVLKVRDWYVESFR 428
M+ G + +LL S ++L +ELP+RIA R +LP+ + P +L V + Y+ +F+
Sbjct: 75 MLYSGRSQDGSHLLKSGRYLQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHELYIRAFQ 134
Query: 429 DMRAFPEIKDTADEKEFTQMIKAVKVRHNNVVPMMALGVNQLKKGMRLYENLDEIHQFLD 608
+ FP IKD ADE ++ Q+++ + H +VV ++A G+ + +K + E+ + FLD
Sbjct: 135 KLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHI---EDEKLVRYFLD 191
Query: 609 RFYLSRIGIRMLIGQHVELHNPNPPLHTVGYIHTKMSPMEVARNASEDARSICFREYGSA 788
+ SR+GIRML H+ LH P VG I T++SP ++ + AR +C +YG+A
Sbjct: 192 KTLTSRLGIRMLATHHLALHEDKPDF--VGIICTRLSPKKIIEKWVDFARRLCEHKYGNA 249
Query: 789 PEINIYGDPSFTFPYVPTHLHLMVYELVKNSLRAVQERFVDSDRVAPPIRIIVADGIEDV 968
P + I G + FP++P L ++ EL+KN++RA E +D+ P + I +A+ D+
Sbjct: 250 PRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDL 309
Query: 969 TIKVSDEGGGIPRSGLPKIFTYLYSTA 1049
I++SD GGGI L ++ Y ++TA
Sbjct: 310 IIRISDRGGGIAHKDLDRVMDYHFTTA 336
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,767,994,010
Number of Sequences: 518415
Number of Extensions: 98767994010
Number of Successful Extensions: 632508636
Number of sequences better than 0.0: 0
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