BLASTX 7.6.2
Query= UN23370 /QuerySize=1999
(1998 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9SE60|MTHR1_ARATH Methylenetetrahydrofolate reductase 1 OS=A... 1171 0.0
sp|O80585|MTHR2_ARATH Methylenetetrahydrofolate reductase 2 OS=A... 1082 0.0
sp|Q75HE6|MTHR_ORYSJ Probable methylenetetrahydrofolate reductas... 985 2e-286
sp|Q9SE94|MTHR1_MAIZE Methylenetetrahydrofolate reductase 1 OS=Z... 985 2e-286
sp|P42898|MTHR_HUMAN Methylenetetrahydrofolate reductase OS=Homo... 506 4e-142
sp|Q60HE5|MTHR_MACFA Methylenetetrahydrofolate reductase OS=Maca... 503 2e-141
sp|Q9WU20|MTHR_MOUSE Methylenetetrahydrofolate reductase OS=Mus ... 499 4e-140
sp|Q5I598|MTHR_BOVIN Methylenetetrahydrofolate reductase OS=Bos ... 498 8e-140
sp|P53128|MTHR2_YEAST Methylenetetrahydrofolate reductase 2 OS=S... 478 8e-134
sp|Q17693|MTHR_CAEEL Probable methylenetetrahydrofolate reductas... 443 3e-123
sp|Q10258|MTHR1_SCHPO Methylenetetrahydrofolate reductase 1 OS=S... 346 5e-094
sp|O74927|MTHR2_SCHPO Methylenetetrahydrofolate reductase 2 OS=S... 228 2e-058
sp|P46151|MTHR1_YEAST Methylenetetrahydrofolate reductase 1 OS=S... 213 4e-054
sp|O67422|METF_AQUAE 5,10-methylenetetrahydrofolate reductase OS... 125 2e-027
sp|P45208|METF_HAEIN 5,10-methylenetetrahydrofolate reductase OS... 101 3e-020
sp|P0AEZ1|METF_ECOLI 5,10-methylenetetrahydrofolate reductase OS... 100 5e-020
sp|P0AEZ2|METF_SHIFL 5,10-methylenetetrahydrofolate reductase OS... 100 5e-020
sp|P11003|METF_SALTY 5,10-methylenetetrahydrofolate reductase OS... 99 1e-019
>sp|Q9SE60|MTHR1_ARATH Methylenetetrahydrofolate reductase 1 OS=Arabidopsis
thaliana GN=MTHFR1 PE=1 SV=1
Length = 592
Score = 1171 bits (3029), Expect = 0.0
Identities = 564/592 (95%), Positives = 582/592 (98%)
Frame = +2
Query: 50 MKVVDKIKSATEQGQTAFSFEFFPPKTDDGVENLFERMDRLVSYGPSFCDITWGAGGSTA 229
MKVVDKIKS TEQGQTAFSFEFFPPKT+DGVENLFERMDRLVSYGP+FCDITWGAGGSTA
Sbjct: 1 MKVVDKIKSVTEQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGGSTA 60
Query: 230 DLTLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDK 409
DLTLEIASRMQN ICVETMMHLTCTNMP+EKIDHALETIRSNGIQNVLALRGDPPHGQDK
Sbjct: 61 DLTLEIASRMQNVICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQDK 120
Query: 410 FVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAYLK 589
FVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEA+GLATPESYQSDLAYLK
Sbjct: 121 FVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAYLK 180
Query: 590 RKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTK 769
+KVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTK
Sbjct: 181 KKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTK 240
Query: 770 IPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITTLHIYTLNVDKSAIGILMNL 949
IPAELTAALEPIKDN+EAVKA+GIHFATEMCKKILAHGIT+LH+YTLNVDKSAIGILMNL
Sbjct: 241 IPAELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSAIGILMNL 300
Query: 950 GLIDESKITRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPQGRWGDSRSA 1129
GLIDESKI+RSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFP GRWGDS SA
Sbjct: 301 GLIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPHGRWGDSHSA 360
Query: 1130 SYGTLSDYQFMRPRARDKKLQQEWAVPLKGIEDVQEKFKELCLGNLKSSPWSELDGLQPE 1309
+Y TLSDYQF RP+ RDKKLQQEW VPLK IEDVQEKFKELC+GNLKSSPWSELDGLQPE
Sbjct: 361 AYSTLSDYQFARPKGRDKKLQQEWVVPLKSIEDVQEKFKELCIGNLKSSPWSELDGLQPE 420
Query: 1310 TKIINEKLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAYLEFFCSKDKLD 1489
TKIINE+LGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAYLEFFCSKDKLD
Sbjct: 421 TKIINEQLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAYLEFFCSKDKLD 480
Query: 1490 TLVEKSKAFPSITFMAVNKAENWVSNIGESDVNAVTWGVFPAKEVIQPTIVDPASFKVWK 1669
TLVEKSKAFPSIT+MAVNK+ENWVSN GESDVNAVTWGVFPAKEVIQPTIVDPASFKVWK
Sbjct: 481 TLVEKSKAFPSITYMAVNKSENWVSNTGESDVNAVTWGVFPAKEVIQPTIVDPASFKVWK 540
Query: 1670 DEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNDYISGDIFSVFA 1825
DEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDN+YI+GDIFSVFA
Sbjct: 541 DEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNNYINGDIFSVFA 592
>sp|O80585|MTHR2_ARATH Methylenetetrahydrofolate reductase 2 OS=Arabidopsis
thaliana GN=MTHFR2 PE=1 SV=2
Length = 594
Score = 1082 bits (2796), Expect = 0.0
Identities = 508/592 (85%), Positives = 556/592 (93%)
Frame = +2
Query: 50 MKVVDKIKSATEQGQTAFSFEFFPPKTDDGVENLFERMDRLVSYGPSFCDITWGAGGSTA 229
MKV+DKI+S ++G+TAFSFEFFPPKT+DGV+NLFERMDR+V+YGP+FCDITWGAGGSTA
Sbjct: 1 MKVIDKIQSLADEGKTAFSFEFFPPKTEDGVDNLFERMDRMVAYGPTFCDITWGAGGSTA 60
Query: 230 DLTLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDK 409
DLTL+IASRMQN +CVE+MMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDK
Sbjct: 61 DLTLDIASRMQNVVCVESMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDK 120
Query: 410 FVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAYLK 589
FVQVEGGF CALDLVNHIRSKYGDYFGITVAGYPEAHPDVI NGLA+ E+YQSDL YLK
Sbjct: 121 FVQVEGGFDCALDLVNHIRSKYGDYFGITVAGYPEAHPDVIGENGLASNEAYQSDLEYLK 180
Query: 590 RKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTK 769
+K+DAGADLIVTQLFYDTDIFLKFVNDCRQIGI+CPIVPGIMPI+NY+GFLRM GFCKTK
Sbjct: 181 KKIDAGADLIVTQLFYDTDIFLKFVNDCRQIGISCPIVPGIMPINNYRGFLRMTGFCKTK 240
Query: 770 IPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITTLHIYTLNVDKSAIGILMNL 949
IP E+ AALEPIKDNEEAVKA+GIH TEMCKK+LAHG+ +LH+YTLN++KSA+ ILMNL
Sbjct: 241 IPVEVMAALEPIKDNEEAVKAYGIHLGTEMCKKMLAHGVKSLHLYTLNMEKSALAILMNL 300
Query: 950 GLIDESKITRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPQGRWGDSRSA 1129
G+IDESKI+RSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGW DFPQGRWGDSRSA
Sbjct: 301 GMIDESKISRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWEDFPQGRWGDSRSA 360
Query: 1130 SYGTLSDYQFMRPRARDKKLQQEWAVPLKGIEDVQEKFKELCLGNLKSSPWSELDGLQPE 1309
SYG LSD+QF RPRARDKKLQQEW VPLK +ED+QEKFKELCLGNLKSSPWSELDGLQPE
Sbjct: 361 SYGALSDHQFSRPRARDKKLQQEWVVPLKSVEDIQEKFKELCLGNLKSSPWSELDGLQPE 420
Query: 1310 TKIINEKLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAYLEFFCSKDKLD 1489
T+IINE+L K+NS GFLTINSQPSVNA +SDSP +GWGGP GYVYQKAYLEFFCSK+KLD
Sbjct: 421 TRIINEQLIKVNSKGFLTINSQPSVNAERSDSPTVGWGGPVGYVYQKAYLEFFCSKEKLD 480
Query: 1490 TLVEKSKAFPSITFMAVNKAENWVSNIGESDVNAVTWGVFPAKEVIQPTIVDPASFKVWK 1669
+VEK KA PSIT+MAVNK E WVSN ++DVNAVTWGVFPAKE+IQPTIVDPASF VWK
Sbjct: 481 AVVEKCKALPSITYMAVNKGEQWVSNTAQADVNAVTWGVFPAKEIIQPTIVDPASFNVWK 540
Query: 1670 DEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNDYISGDIFSVFA 1825
DEAFE WSRSWANLYPE DPSR LLEEVKNSYYLVSLV+NDYI+GDIF+VFA
Sbjct: 541 DEAFETWSRSWANLYPEADPSRNLLEEVKNSYYLVSLVENDYINGDIFAVFA 592
>sp|Q75HE6|MTHR_ORYSJ Probable methylenetetrahydrofolate reductase OS=Oryza
sativa subsp. japonica GN=Os03g0815200 PE=2 SV=1
Length = 594
Score = 985 bits (2546), Expect = 2e-286
Identities = 459/591 (77%), Positives = 527/591 (89%)
Frame = +2
Query: 50 MKVVDKIKSATEQGQTAFSFEFFPPKTDDGVENLFERMDRLVSYGPSFCDITWGAGGSTA 229
MKV++KI+ A G+T FSFE+FPPKT++G++NLFERMDR+V++GP+FCDITWGAGGSTA
Sbjct: 1 MKVIEKIQEAAADGRTVFSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGGSTA 60
Query: 230 DLTLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDK 409
DLTLEIA+RMQN +CVETMMHLTCTNMPVEKID AL TI+SNGIQNVLALRGDPPHGQDK
Sbjct: 61 DLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDDALTTIKSNGIQNVLALRGDPPHGQDK 120
Query: 410 FVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAYLK 589
FVQV GGFACALDLV HIR+KYGDYFGITVAGYPEAHPD I++ ATPE+Y +DLAYLK
Sbjct: 121 FVQVAGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQSTEGATPEAYSNDLAYLK 180
Query: 590 RKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTK 769
+KVDAGADLI+TQLFYDTDIFLKFVNDCRQIGI CPIVPGIMPI+NYKGFLRM GFCKTK
Sbjct: 181 QKVDAGADLIITQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCKTK 240
Query: 770 IPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITTLHIYTLNVDKSAIGILMNL 949
IPAE+TAALEPIKDNEEAVKA+GIH TEMCKKILA GI TLH+YTLN++KSA+GILMNL
Sbjct: 241 IPAEITAALEPIKDNEEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSALGILMNL 300
Query: 950 GLIDESKITRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPQGRWGDSRSA 1129
GLI+ESKI+RSLPWR P NVFR KEDVRPIFWANRPKSYISRT GW+ +P GRWGDSR+
Sbjct: 301 GLIEESKISRSLPWRPPTNVFRVKEDVRPIFWANRPKSYISRTLGWDQYPHGRWGDSRNP 360
Query: 1130 SYGTLSDYQFMRPRARDKKLQQEWAVPLKGIEDVQEKFKELCLGNLKSSPWSELDGLQPE 1309
SYG L+DYQF RPR R KKLQ+EWAVP+K +ED+ E+F C G L SSPWSELDGLQPE
Sbjct: 361 SYGALTDYQFTRPRGRGKKLQEEWAVPVKSVEDINERFMNFCQGKLTSSPWSELDGLQPE 420
Query: 1310 TKIINEKLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAYLEFFCSKDKLD 1489
TKII+++L KIN GFLTINSQP+VN +SDS ++GWGGPGGYVYQKAYLEFFCSK+KLD
Sbjct: 421 TKIIDDQLVKINQKGFLTINSQPAVNGERSDSTSVGWGGPGGYVYQKAYLEFFCSKEKLD 480
Query: 1490 TLVEKSKAFPSITFMAVNKAENWVSNIGESDVNAVTWGVFPAKEVIQPTIVDPASFKVWK 1669
L+EKSKAFPS+T++AVNK SNI + VNAVTWGVFP KE++QPT+VD ASF VWK
Sbjct: 481 QLIEKSKAFPSLTYIAVNKDGESFSNIPTNAVNAVTWGVFPGKEIVQPTVVDSASFMVWK 540
Query: 1670 DEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNDYISGDIFSVF 1822
DEAFEIWS+ WA L+PE D SR++L++V+ SY+LVSLVDNDYI+GD+F+ F
Sbjct: 541 DEAFEIWSKGWACLFPEGDSSREILDKVQKSYFLVSLVDNDYINGDLFAAF 591
>sp|Q9SE94|MTHR1_MAIZE Methylenetetrahydrofolate reductase 1 OS=Zea mays PE=2
SV=1
Length = 593
Score = 985 bits (2545), Expect = 2e-286
Identities = 460/591 (77%), Positives = 521/591 (88%)
Frame = +2
Query: 50 MKVVDKIKSATEQGQTAFSFEFFPPKTDDGVENLFERMDRLVSYGPSFCDITWGAGGSTA 229
MKV++KI A G+TAFSFE+FPPKT++GVENLFERMDR+V++GPSFCDITWGAGGSTA
Sbjct: 1 MKVIEKILEAAGDGRTAFSFEYFPPKTEEGVENLFERMDRMVAHGPSFCDITWGAGGSTA 60
Query: 230 DLTLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDK 409
DLTLEIA+RMQN +CVETMMHLTCTNMPVEKIDHALETI+SNGIQNVLALRGDPPHGQDK
Sbjct: 61 DLTLEIANRMQNMVCVETMMHLTCTNMPVEKIDHALETIKSNGIQNVLALRGDPPHGQDK 120
Query: 410 FVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAYLK 589
FVQVEGGFACALDLV HIR+KYGDYFGITVAGYPEAHPD I+ G AT E+Y +DLAYLK
Sbjct: 121 FVQVEGGFACALDLVQHIRAKYGDYFGITVAGYPEAHPDAIQGEGGATLEAYSNDLAYLK 180
Query: 590 RKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTK 769
RKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGI CPIVPGIMPI+NYKGFLRM GFCKTK
Sbjct: 181 RKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCKTK 240
Query: 770 IPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITTLHIYTLNVDKSAIGILMNL 949
IP+E+TAAL+PIKDNEEAV+ +GIH TEMCKKILA GI TLH+YTLN+DKSAIGILMNL
Sbjct: 241 IPSEITAALDPIKDNEEAVRQYGIHLGTEMCKKILATGIKTLHLYTLNMDKSAIGILMNL 300
Query: 950 GLIDESKITRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPQGRWGDSRSA 1129
GLI+ESK++R LPWR NVFR KEDVRPIFWANRPKSY+ RT GW+ +P GRWGDSR+
Sbjct: 301 GLIEESKVSRPLPWRPATNVFRVKEDVRPIFWANRPKSYLKRTLGWDQYPHGRWGDSRNP 360
Query: 1130 SYGTLSDYQFMRPRARDKKLQQEWAVPLKGIEDVQEKFKELCLGNLKSSPWSELDGLQPE 1309
SYG L+D+QF RPR R KKLQ+EWAVPLK +ED+ E+F C G L SSPWSELDGLQPE
Sbjct: 361 SYGALTDHQFTRPRGRGKKLQEEWAVPLKSVEDISERFTNFCQGKLTSSPWSELDGLQPE 420
Query: 1310 TKIINEKLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAYLEFFCSKDKLD 1489
TKII+++L IN GFLTINSQP+VN KSDSP +GWGGPGGYVYQKAYLEFFC+K+KLD
Sbjct: 421 TKIIDDQLVNINQKGFLTINSQPAVNGEKSDSPTVGWGGPGGYVYQKAYLEFFCAKEKLD 480
Query: 1490 TLVEKSKAFPSITFMAVNKAENWVSNIGESDVNAVTWGVFPAKEVIQPTIVDPASFKVWK 1669
L+EK KAFPS+T++AVNK SNI + VNAVTWGVFP KE+IQPT+VD ASF VWK
Sbjct: 481 QLIEKIKAFPSLTYIAVNKDGETFSNISPNAVNAVTWGVFPGKEIIQPTVVDHASFMVWK 540
Query: 1670 DEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNDYISGDIFSVF 1822
DEAFEIW+R W ++PE D SR+LLE+V+ +YYLVSLVDNDY+ GD+F+ F
Sbjct: 541 DEAFEIWTRGWGCMFPEGDSSRELLEKVQKTYYLVSLVDNDYVQGDLFAAF 591
>sp|P42898|MTHR_HUMAN Methylenetetrahydrofolate reductase OS=Homo sapiens
GN=MTHFR PE=1 SV=3
Length = 656
Score = 506 bits (1301), Expect = 4e-142
Identities = 256/594 (43%), Positives = 369/594 (62%), Gaps = 30/594 (5%)
Frame = +2
Query: 62 DKIKSATEQGQTAFSFEFFPPKTDDGVENLFERMDRLVSYGPSFCDITWGAGGSTAD--- 232
+K++ E G FS EFFPP+T +G NL R DR+ + GP + D+TW G
Sbjct: 47 EKMRRRLESGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPGSDKE 106
Query: 233 -LTLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDK 409
++ IAS N +ET++H+TC +E+I L + G++N++ALRGDP D+
Sbjct: 107 TSSMMIASTAVNYCGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDPI--GDQ 164
Query: 410 FVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAYLK 589
+ + EGGF A+DLV HIRS++GDYF I VAGYP+ HP+ S+++DL +LK
Sbjct: 165 WEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEA---------GSFEADLKHLK 215
Query: 590 RKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTK 769
KV AGAD I+TQLF++ D F +FV C +GI CPIVPGI PI Y ++ K +
Sbjct: 216 EKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLE 275
Query: 770 IPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITT-LHIYTLNVDKSAIGILMN 946
+P E+ +EPIKDN+ A++ +GI A +C+++LA G+ LH YTLN + + +L
Sbjct: 276 VPQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLKR 335
Query: 947 LGLIDESKITRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPQGRWGDSRS 1126
LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+ W++FP GRWG+S S
Sbjct: 336 LGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSS 394
Query: 1127 ASYGTLSDYQ--FMRPRARDKKLQQEWAVPLKGIEDVQEKFKELCLG-------NLKSSP 1279
++G L DY +++ ++ ++L + W L E V E F G + P
Sbjct: 395 PAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLYLSGEPNRNGHKVTCLP 454
Query: 1280 WSELDGLQPETKIINEKLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAYL 1459
W++ + L ET ++ E+L ++N G LTINSQP++N S P +GWG GGYV+QKAYL
Sbjct: 455 WND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPIVGWGPSGGYVFQKAYL 513
Query: 1460 EFFCSKDKLDTLVEKSKAFP-SITFMAVN-KAENWVSNIGESDVNAVTWGVFPAKEVIQP 1633
EFF S++ + L++ K + + + VN K EN ++N E NAVTWG+FP +E+IQP
Sbjct: 514 EFFTSRETAEALLQVLKKYELRVNYHLVNVKGEN-ITNAPELQPNAVTWGIFPGREIIQP 572
Query: 1634 TIVDPASFKVWKDEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNDY 1795
T+VDP SF WKDEAF +W W LY E+ PSR +++ + ++Y+LV+LVDND+
Sbjct: 573 TVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYFLVNLVDNDF 626
>sp|Q60HE5|MTHR_MACFA Methylenetetrahydrofolate reductase OS=Macaca fascicularis
GN=MTHFR PE=2 SV=1
Length = 656
Score = 503 bits (1295), Expect = 2e-141
Identities = 257/594 (43%), Positives = 367/594 (61%), Gaps = 30/594 (5%)
Frame = +2
Query: 62 DKIKSATEQGQTAFSFEFFPPKTDDGVENLFERMDRLVSYGPSFCDITWGAGGSTAD--- 232
DK++ E G FS EFFPP+T +G NL R DR+ + GP F D+TW G
Sbjct: 47 DKMRRRMESGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLFIDVTWHPAGDPGSDKE 106
Query: 233 -LTLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDK 409
++ IAS N +ET++H+TC +E+I L + G++N++ALRGDP D+
Sbjct: 107 TSSMMIASTAVNYCGLETILHMTCCCQRLEEITGHLHKAKQLGLKNIMALRGDPI--GDQ 164
Query: 410 FVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAYLK 589
+ + EGGF A+DLV HIRS++GDYF + VAGYP+ HP+ S+++DL +LK
Sbjct: 165 WEEEEGGFNYAVDLVKHIRSEFGDYFDLCVAGYPKGHPEA---------GSFEADLKHLK 215
Query: 590 RKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTK 769
KV AGAD I+TQLF++ D F +FV C +GI CPIVPGI PI Y ++ K +
Sbjct: 216 EKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKQSKLE 275
Query: 770 IPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITT-LHIYTLNVDKSAIGILMN 946
+P E+ +EPIKDN+ A++ +GI A +C ++LA G+ LH YTLN + + +L
Sbjct: 276 VPQEIKDVIEPIKDNDAAIRNYGIELAVSLCHELLASGLVPGLHFYTLNREMATTEVLKR 335
Query: 947 LGLIDESKITRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPQGRWGDSRS 1126
LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+ W++FP GRWG+S S
Sbjct: 336 LGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSS 394
Query: 1127 ASYGTLSDYQ--FMRPRARDKKLQQEWAVPLKGIEDVQEKFKELCLG-------NLKSSP 1279
++G L DY +++ ++ + L + W L E V E F G + P
Sbjct: 395 PAFGELKDYYLFYLKSKSPRELLLKMWGEELTSEESVFEVFVLYLSGEPNRNGHKVTCLP 454
Query: 1280 WSELDGLQPETKIINEKLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAYL 1459
W++ + L ET ++ E+L ++N G LTINSQP++N S P +GWG GGYV+QKAYL
Sbjct: 455 WND-EPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPVVGWGPSGGYVFQKAYL 513
Query: 1460 EFFCSKDKLDTLVEKSKAFP-SITFMAVN-KAENWVSNIGESDVNAVTWGVFPAKEVIQP 1633
EFF S++ + L++ K + + + VN K EN ++N E NAVTWG+FP +E+IQP
Sbjct: 514 EFFTSRETAEALLQVLKKYELRVNYHLVNVKGEN-ITNAPELQPNAVTWGIFPGREIIQP 572
Query: 1634 TIVDPASFKVWKDEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNDY 1795
T+VDP SF WKDEAF +W W LY E+ PSR +++ + ++Y+LV+LVDND+
Sbjct: 573 TVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRTIIQYIHDNYFLVNLVDNDF 626
>sp|Q9WU20|MTHR_MOUSE Methylenetetrahydrofolate reductase OS=Mus musculus
GN=Mthfr PE=2 SV=1
Length = 654
Score = 499 bits (1283), Expect = 4e-140
Identities = 252/594 (42%), Positives = 367/594 (61%), Gaps = 30/594 (5%)
Frame = +2
Query: 62 DKIKSATEQGQTAFSFEFFPPKTDDGVENLFERMDRLVSYGPSFCDITWGAGGSTAD--- 232
+K++ + G FS EFFPP+T +G NL R DR+ + GP F D+TW G
Sbjct: 46 EKMRRRMDSGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLFVDVTWHPAGDPGSDKE 105
Query: 233 -LTLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDK 409
++ IAS N +ET++H+TC E+I L + G++N++ALRGDP D
Sbjct: 106 TSSMMIASTAVNYCGLETILHMTCCQQRPEEITGHLHRAKQLGLKNIMALRGDPV--GDH 163
Query: 410 FVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAYLK 589
+ EGGF+ A DLV HIR+++ DYF I VAGYP HPD ES++ DL +LK
Sbjct: 164 WEAEEGGFSYATDLVKHIRTEFADYFDICVAGYPRGHPDA---------ESFEDDLKHLK 214
Query: 590 RKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTK 769
KV AGAD I+TQLF++ F FV C +IGI+CPI+PGI PI Y ++ K +
Sbjct: 215 EKVSAGADFIITQLFFEASTFFSFVKACTEIGISCPILPGIFPIQGYTSLRQLVKLSKLE 274
Query: 770 IPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITT-LHIYTLNVDKSAIGILMN 946
+P ++ +EPIKDN+ A++ +GI A +C+++L G+ LH YTLN + + + +L
Sbjct: 275 VPQKIKDVIEPIKDNDAAIRNYGIELAVRLCRELLDSGLVPGLHFYTLNREVATMEVLKQ 334
Query: 947 LGLIDESKITRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPQGRWGDSRS 1126
LG+ E R LPW A+ R +EDVRPIFWA+RPKSYI RT+ W++FP GRWG+S S
Sbjct: 335 LGMWTEDP-RRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQDWDEFPNGRWGNSSS 393
Query: 1127 ASYGTLSDYQ--FMRPRARDKKLQQEWAVPLKGIEDVQEKFKELCLG-------NLKSSP 1279
++G L DY +++ ++ ++L + W L E V E F+ G + P
Sbjct: 394 PAFGELKDYYLFYLKSKSPREELLKMWGEELTSEESVFEVFEHYLSGEPNRHGYRVTCLP 453
Query: 1280 WSELDGLQPETKIINEKLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAYL 1459
W++ + L ET ++ E+L ++N G LTINSQP++NA S P +GWG GGYV+QKAYL
Sbjct: 454 WND-EPLAAETSLMKEELLRVNRLGILTINSQPNINAKPSSDPVVGWGPSGGYVFQKAYL 512
Query: 1460 EFFCSKDKLDTLVEKSKAFP-SITFMAVN-KAENWVSNIGESDVNAVTWGVFPAKEVIQP 1633
EFF S++ ++ L++ K + + + V+ K EN ++N E NAVTWG+FP +E+IQP
Sbjct: 513 EFFTSRETVEALLQVLKTYELRVNYHIVDVKGEN-ITNAPELQPNAVTWGIFPGREIIQP 571
Query: 1634 TIVDPASFKVWKDEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNDY 1795
T+VDP SF WKDEAF +W W LY E+ PSR +++ + ++Y+LV+LVDN++
Sbjct: 572 TVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYFLVNLVDNEF 625
>sp|Q5I598|MTHR_BOVIN Methylenetetrahydrofolate reductase OS=Bos taurus GN=MTHFR
PE=2 SV=1
Length = 655
Score = 498 bits (1281), Expect = 8e-140
Identities = 253/594 (42%), Positives = 370/594 (62%), Gaps = 30/594 (5%)
Frame = +2
Query: 62 DKIKSATEQGQTAFSFEFFPPKTDDGVENLFERMDRLVSYGPSFCDITWGAGGSTAD--- 232
+K+K + G FS EFFPP+T G NL R DR+ + GP F D+TW G
Sbjct: 46 EKMKRKMDSGDKWFSLEFFPPRTAQGAVNLISRFDRMGAGGPLFVDVTWHPAGDPGSDKE 105
Query: 233 -LTLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDK 409
++ IAS N +ET++H+TC + E+I L + G++N+LALRGDP D+
Sbjct: 106 TSSMVIASTAVNYCGLETILHMTCCHQSREEITGHLNKAKQLGLKNILALRGDPI--GDQ 163
Query: 410 FVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAYLK 589
+ + EGGF A DLV HIR+++GDYF + VAGYP+ HP+ ES+++DL +LK
Sbjct: 164 WEEEEGGFNYATDLVKHIRNEFGDYFDVCVAGYPKGHPE---------GESFEADLKHLK 214
Query: 590 RKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKTK 769
KV AGAD I+TQLF++ + F +FV C +IGI CP++PGI PI Y ++ K +
Sbjct: 215 EKVAAGADFIITQLFFEAETFFRFVKACSEIGITCPVLPGIFPIQGYHSLRQLVKLSKLE 274
Query: 770 IPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITT-LHIYTLNVDKSAIGILMN 946
+P ++ +EPIKDN+ A++ +GI A +C+++LA G+ LH YTLN + + I +L
Sbjct: 275 VPQQIKDVIEPIKDNDAAIRNYGIEQAVSLCQELLASGLVPGLHFYTLNREVATIEVLKR 334
Query: 947 LGLIDESKITRSLPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPQGRWGDSRS 1126
LGL E R LPW A+ R EDVRPIFWA+RPKSYI RT+ W++FP GRWG+S S
Sbjct: 335 LGLWIEDP-RRPLPWALSAHPKRRVEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSS 393
Query: 1127 ASYGTLSDYQ--FMRPRARDKKLQQEWAVPLKGIEDVQEKFKELCLGNLKSS-------P 1279
++G L DY +++ ++ ++L + W L E V + F G + P
Sbjct: 394 PAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFQVFAHHLSGEPNQNGYKVTCLP 453
Query: 1280 WSELDGLQPETKIINEKLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAYL 1459
W++ + L ET ++ E+L ++N G LTINSQP++N S P +GWG GGYV+QKAYL
Sbjct: 454 WND-EPLAAETSLMKEELLRVNRRGILTINSQPNINGKPSSDPIVGWGPSGGYVFQKAYL 512
Query: 1460 EFFCSKDKLDTLVEKSKAFP-SITFMAVN-KAENWVSNIGESDVNAVTWGVFPAKEVIQP 1633
EFF S++ ++ L++ K + + + V+ K EN ++N E NAVTWG+FP +E+IQP
Sbjct: 513 EFFTSRETVEALLQVLKKYELRVNYHIVDVKGEN-ITNAPELQPNAVTWGIFPGREIIQP 571
Query: 1634 TIVDPASFKVWKDEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNDY 1795
T+VDP SF WKDEAF +W W LY E+ PSR +++ + ++Y+LV+LVDN++
Sbjct: 572 TVVDPVSFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYFLVNLVDNEF 625
>sp|P53128|MTHR2_YEAST Methylenetetrahydrofolate reductase 2 OS=Saccharomyces
cerevisiae GN=MET13 PE=1 SV=2
Length = 600
Score = 478 bits (1229), Expect = 8e-134
Identities = 257/599 (42%), Positives = 367/599 (61%), Gaps = 22/599 (3%)
Frame = +2
Query: 50 MKVVDKIKSATE-QGQTAFSFEFFPPKTDDGVENLFERMDRLVSYG-PSFCDITWGAGGS 223
MK+ +K++ + G+ +SFE+F PKT GV+NL++RMDR+ P F DITW AGG
Sbjct: 1 MKITEKLEQHRQTSGKPTYSFEYFVPKTTQGVQNLYDRMDRMYEASLPQFIDITWNAGGG 60
Query: 224 -TADLTLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHG 400
+ L+ ++ + Q+ + +ET MHLTCTNMP+ ID ALE +G QN+LALRGDPP
Sbjct: 61 RLSHLSTDLVATAQSVLGLETCMHLTCTNMPISMIDDALENAYHSGCQNILALRGDPPRD 120
Query: 401 QDKFVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLA 580
+ + VEGGF A DL+ +I+SKYGD+F I VAGYPE HP++ + + DL
Sbjct: 121 AENWTPVEGGFQYAKDLIKYIKSKYGDHFAIGVAGYPECHPEL-------PNKDVKLDLE 173
Query: 581 YLKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFC 760
YLK+K+DAG D I+TQ+FYD D F+ + + R G++ PI+PGIMPI+ Y FLR A +
Sbjct: 174 YLKQKIDAGGDFIITQMFYDVDNFINWCSQVRAAGMDVPIIPGIMPITTYAAFLRRAQWG 233
Query: 761 KTKIPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHG-ITTLHIYTLNVDKSAIGI 937
+ IP ++ L+PIKD++E V+ G + EMC+K+L G ++ LHIYT+N++K+ + I
Sbjct: 234 QISIPQHFSSRLDPIKDDDELVRDIGTNLIVEMCQKLLDSGYVSHLHIYTMNLEKAPLMI 293
Query: 938 LMNLGLI-DESKITRS----LPWRRPANVFRTKEDVRPIFWANRPKSYISRTKGW--NDF 1096
L L ++ ES+ LPWR+ N R E+VRPIFW RP SY++RT W ++F
Sbjct: 294 LERLNILPTESEFNAHPLAVLPWRKSLNPKRKNEEVRPIFWKRRPYSYVARTSQWAVDEF 353
Query: 1097 PQGRWGDSRSASYGTLSDYQFMRPRARDKKLQQEWAVPLKGIEDVQEKFKELCLGNLKSS 1276
P GR+GDS S ++G L R K + W+ P I DV GNLK
Sbjct: 354 PNGRFGDSSSPAFGDLDLCGSDLIRQSANKCLELWSTP-TSINDVAFLVINYLNGNLKCL 412
Query: 1277 PWSELDGLQPETKIINEKLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQKAY 1456
PWS++ + E I L ++N + +TINSQP VN +S+ GWG GYVYQK Y
Sbjct: 413 PWSDIP-INDEINPIKAHLIELNQHSIITINSQPQVNGIRSNDKIHGWGPKDGYVYQKQY 471
Query: 1457 LEFFCSKDKLDTLVEKSKAFPSITFMAVNKAENWVSNIGE-SDVNAVTWGVFPAKEVIQP 1633
LEF K KL L++ K +T+ A++ + +SN + S NAVTWG+FP +E++QP
Sbjct: 472 LEFMLPKTKLPKLIDTLKNNEFLTYFAIDSQGDLLSNHPDNSKSNAVTWGIFPGREILQP 531
Query: 1634 TIVDPASFKVWKDEAFEIWSRSWANLYPEDDP-SRKLLEEVKNSYYLVSLVDNDYISGD 1807
TIV+ SF WK+E + I + N+ D P S + ++ + + Y LV++VDNDYIS D
Sbjct: 532 TIVEKISFLAWKEEFYHILNEWKLNMNKYDKPHSAQFIQSLIDDYCLVNIVDNDYISPD 590
>sp|Q17693|MTHR_CAEEL Probable methylenetetrahydrofolate reductase
OS=Caenorhabditis elegans GN=C06A8.1 PE=1 SV=2
Length = 663
Score = 443 bits (1138), Expect = 3e-123
Identities = 243/599 (40%), Positives = 360/599 (60%), Gaps = 35/599 (5%)
Frame = +2
Query: 62 DKIKSATEQGQTAFSFEFFPPKTDDGVENLFERMDRLVSYGPSFCDITWGAGGSTADL-- 235
++I+ ++ Q FS EFFPP+ +GV N ER++RL G F D+TW G A++
Sbjct: 60 ERIERLIDEKQQFFSLEFFPPRFVNGVPNFLERVERLSEGGSVFVDMTWHMGSDPANVDK 119
Query: 236 ---TLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQD 406
+ IA+ M + V+TM+H+TC LE ++ G++++LALRGD P G +
Sbjct: 120 VTSSSSIAASMLDYCGVDTMLHMTCVQYNKADTLKHLEQAKAMGLRSILALRGDLPPGTE 179
Query: 407 KFVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAYL 586
++ F ALD++ IR +YG+YF I AGYP HP SY++DL YL
Sbjct: 180 --LEDTHQFR-ALDMIRWIREEYGNYFSIGCAGYPLGHPQA---------PSYKADLMYL 227
Query: 587 KRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKT 766
K K DAGA+ ++TQLF++ + F KFV DCR+IGI PI+PGIMPI Y+ R+A +
Sbjct: 228 KAKCDAGANFVITQLFFEAETFEKFVRDCREIGITQPIIPGIMPIMGYESIKRIAKLSQL 287
Query: 767 KIPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGIT-TLHIYTLNVDKSAIGILM 943
+IP + LEPIK +++AV+ +G EMC+++L +G ++H+YT+N + S IL
Sbjct: 288 EIPQHILDDLEPIKHDDDAVQKYGTERCIEMCRRLLDNGTAPSIHLYTMNREGSIREILK 347
Query: 944 NLGLIDESKITRSLPWR-RPANVFRTKEDVRPIFWANRPKSYISRTKGWNDFPQGRWGDS 1120
+LGL + + R PW+ R + R E VRPI+W+ RP+SYI+RT+ W+ FP GRWG+S
Sbjct: 348 SLGLW-KLEGDRVFPWKNRSQHPIRCLESVRPIYWSFRPRSYITRTRDWDQFPNGRWGNS 406
Query: 1121 RSASYGTLSDY---QFMRPRARDKKLQQEWAVPLKGIEDVQEKFKELCLG-------NLK 1270
S ++G +S Y R D +L + ++ EDV+ F +
Sbjct: 407 SSPAFGDVSSYYLSNLTTVRNADDRLAM-FGANIESFEDVKRVFINYITQAPNADGVKVT 465
Query: 1271 SSPWSELD-GLQPETKIINEKLGKINSNGFLTINSQPSVNAAKSDSPAIGWGGPGGYVYQ 1447
PW+E + G+QPET +I+E+L N NG LT+NSQPSVN A S P +GWG PGGY YQ
Sbjct: 466 VLPWTEAETGVQPETSLISEQLVWCNENGILTVNSQPSVNGAPSTDPLVGWGKPGGYCYQ 525
Query: 1448 KAYLEFFCSKDKLDTLVE-KSKAFP-SITFMAVNKAENW-VSNIGESDVNAVTWGVFPAK 1618
KAYLE F + + D L++ + FP + + A+NK + +N E+ AVTWGVFP
Sbjct: 526 KAYLECFMTAELSDKLIQIIEREFPVRVNYHAINKDSTFDKTNSEETTPIAVTWGVFPGS 585
Query: 1619 EVIQPTIVDPASFKVWKDEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSLVDNDY 1795
E+ QPT+VDP SF+ W+DEA+++W W + YP++ S +++ V + + LV+LVDND+
Sbjct: 586 EIAQPTVVDPLSFRAWRDEAYQMWMAQWGDFYPKESKSYGVIKAVHDEFRLVTLVDNDF 644
>sp|Q10258|MTHR1_SCHPO Methylenetetrahydrofolate reductase 1
OS=Schizosaccharomyces pombe GN=met9 PE=1 SV=1
Length = 603
Score = 346 bits (886), Expect = 5e-094
Identities = 185/435 (42%), Positives = 255/435 (58%), Gaps = 16/435 (3%)
Frame = +2
Query: 554 PESYQSD------LAYLKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIM 715
PE Y D + +LK KVD GAD IVTQ+FYD D F+ +V+ R GIN PI PGIM
Sbjct: 154 PEGYSPDDDIDESIKHLKLKVDEGADFIVTQMFYDVDNFIAWVDKVRAAGINIPIFPGIM 213
Query: 716 PISNYKGFLRMAGFCKTKIPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITTL 895
PI + F+R A + KIP L P+KD++E V+ G+ EMC+K++A GIT L
Sbjct: 214 PIQAWDSFIRRAKWSGVKIPQHFMDTLVPVKDDDEGVRERGVELIVEMCRKLIASGITRL 273
Query: 896 HIYTLNVDKSAIGILMNLGLIDESKI----TRSLPWRRPANV-FRTKEDVRPIFWANRPK 1060
H YT+N++K+ I+ LGL+DE+ T ++ ++ R E VRPIFW R +
Sbjct: 274 HFYTMNLEKAVKMIIERLGLLDENLAPIVDTNNVELTNASSQDRRINEGVRPIFWRTRNE 333
Query: 1061 SYISRTKGWNDFPQGRWGDSRSASYGTLSDYQFMRPRARDKKLQQEWAVPLKGIEDVQEK 1240
SY+SRT W++ P GRWGDSRS ++G ++ R K++ W P K ++ +
Sbjct: 334 SYVSRTDQWDELPHGRWGDSRSPAFGEFDAIRY-GLRMSPKEITTSWGSP-KSYSEIGDL 391
Query: 1241 FKELCLGNLKSSPWSELDGLQPETKIINEKLGKINSNGFLTINSQPSVNAAKSDSPAIGW 1420
F C + S PWS+L + E +I ++L +N N FLTINSQP++N KS P GW
Sbjct: 392 FARYCEKKISSLPWSDLP-ISDEADLIRDQLLSMNRNAFLTINSQPALNGEKSSHPVFGW 450
Query: 1421 GGPGGYVYQKAYLEFFCSKDKLDTLVEKSKAFPSITFMAVNKAENWVSNIGESDVNAVTW 1600
G P GYV+QK Y+EFF L+ L E K S+++ NK + +N NAVTW
Sbjct: 451 GPPNGYVFQKPYVEFFVHPSLLNELKETVKKLNSVSYFVTNKNGDLDTNSQYEIPNAVTW 510
Query: 1601 GVFPAKEVIQPTIVDPASFKVWKDEAFEIWSRSWANLYPEDDPSRKLLEEVKNSYYLVSL 1780
GVFP +E+IQPTIV+ SF WKDEA+ + WAN Y D SRKLL + ++L +
Sbjct: 511 GVFPNREIIQPTIVESTSFLAWKDEAYSL-GMEWANAYSPDSISRKLLVSMMKEWFLCVI 569
Query: 1781 VDNDYISG-DIFSVF 1822
VDND+ +G +F VF
Sbjct: 570 VDNDFQNGQSLFDVF 584
>sp|O74927|MTHR2_SCHPO Methylenetetrahydrofolate reductase 2
OS=Schizosaccharomyces pombe GN=met11 PE=2 SV=2
Length = 641
Score = 228 bits (579), Expect = 2e-058
Identities = 129/314 (41%), Positives = 179/314 (57%), Gaps = 18/314 (5%)
Frame = +2
Query: 50 MKVVDKIKSATEQGQTAFSFEFFPPKTDDGVENLFERMDRLV-SYGPSFCDITWGAGGST 226
MK+VD I G +SFE+FPPKT G+ENL R+ R+ + P F +TWG GST
Sbjct: 1 MKIVDLI-DKIPNGNAFYSFEYFPPKTTVGLENLSSRITRMSRNMMPLFSSVTWGTAGST 59
Query: 227 ADLTLEIASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQD 406
A++++ +A ++ + +HLTCTN+ ID ALET + GI+N+LALRGDPP D
Sbjct: 60 AEVSIYLAKMLEQHHKIPACLHLTCTNVDKAIIDKALETAKEYGIRNILALRGDPPLNSD 119
Query: 407 KFVQVEGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAYL 586
+ F A+DLV +IR KYGDYF I VA YPE H +++N + D+ +L
Sbjct: 120 HWEGKVSEFEHAVDLVRYIREKYGDYFCIGVAAYPEGH---VDSNVPELSKDPLRDIPFL 176
Query: 587 KRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINC----PIVPGIMPISNYKGFLRMAG 754
KV+AGAD I+TQ+FY+ + F+KF N R N PI+P IMPI +Y RM
Sbjct: 177 IEKVEAGADFIITQIFYEPEAFIKFENFVRNHSSNALRNIPIIPAIMPIQSYGSLKRMTR 236
Query: 755 FCKTKIPAELTAALEPIKDNEEAVKAFGIHFATEMCKKIL------AHGITTLHIYTLNV 916
C +P+ L L K ++EA+K G+ +M KKI+ HG H TLN+
Sbjct: 237 LCGCSVPSSLMQRLNAAKPDDEAIKNIGVEHIVDMIKKIMDNVQGRVHG---FHFCTLNL 293
Query: 917 DKSAIGILMNLGLI 958
++S IL N GL+
Sbjct: 294 ERSVALILKNSGLL 307
Score = 180 bits (455), Expect = 5e-044
Identities = 93/255 (36%), Positives = 145/255 (56%), Gaps = 8/255 (3%)
Frame = +2
Query: 1040 FWANRPKSYISRTKGWNDFPQGRWGDSRSASYGTLSDY--QFMRPRARDKKLQQEWAVPL 1213
F + + R W+DF GR+GD RS +YG + Y P + KL W P+
Sbjct: 380 FSVSEGSGVLGRQANWDDFTNGRFGDPRSPAYGEIDGYGPTLHFPPSEALKL---WGYPV 436
Query: 1214 KGIEDVQEKFKELCLGNLKSSPWSELDGLQPETKIINEKLGKINSNGFLTINSQPSVNAA 1393
D+ F++ + ++ + PW + + ++ ETK I + L K+N N + T+ SQP+VN A
Sbjct: 437 DE-SDITSLFQKHIMSDISAIPWID-EPVEVETKTIAKYLLKLNGNSWWTVGSQPAVNGA 494
Query: 1394 KSDSPAIGWGGPGGYVYQKAYLEFFCSKDKLDTLVEKSKAFPSITFMAVNKAENWVSNIG 1573
S P GWG GG V+QKA++E F + L + K P +T+ A N +++N
Sbjct: 495 PSADPVFGWGPKGGRVFQKAFVECFVNGKDLKDFITKWHDNPQVTYYAGNNKSEFLTNAP 554
Query: 1574 ESDVNAVTWGVFPAKEVIQPTIVDPASFKVWKDEAFEIWSRSWANLYPEDDPSRKLLEEV 1753
+ +AVTWGV+P +E+IQ TI+ SFK W E+F++W WANLY ++ PSRKLLE
Sbjct: 555 KDGASAVTWGVYPGREIIQSTIIAEVSFKAWLSESFQVWG-EWANLYSKNTPSRKLLENC 613
Query: 1754 KNSYYLVSLVDNDYI 1798
N +LV+++ +D++
Sbjct: 614 INDRWLVTVIHHDFM 628
>sp|P46151|MTHR1_YEAST Methylenetetrahydrofolate reductase 1 OS=Saccharomyces
cerevisiae GN=MET12 PE=1 SV=2
Length = 657
Score = 213 bits (542), Expect = 4e-054
Identities = 122/286 (42%), Positives = 166/286 (58%), Gaps = 10/286 (3%)
Frame = +2
Query: 104 SFEFFPPKTDDGVENLFERMDRLVSYGPSFCDITWGAGGSTADLTLEIASRMQNAICVET 283
S EFFPPKT+ G NL ERM R+ + P F +TWGAGG+TA+ TL +AS Q + +
Sbjct: 16 SLEFFPPKTELGTRNLMERMHRMTALDPLFITVTWGAGGTTAEKTLTLASLAQQTLNIPV 75
Query: 284 MMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQD--KFVQVEGGFACALDLVN 457
MHLTCTN ID AL+ + GI+N+LALRGDPP G+D E F A+DLV
Sbjct: 76 CMHLTCTNTEKAIIDDALDRCYNAGIRNILALRGDPPIGEDWLDSQSNESPFKYAVDLVR 135
Query: 458 HIRSKYGDYFGITVAGYPEAHPDVIEANGLATPESYQSDLAYLKRKVDAGADLIVTQLFY 637
+I+ YGD F + VA YPE H E + DL YLK KV+AGAD ++TQLFY
Sbjct: 136 YIKQSYGDKFCVGVAAYPEGH---CEGEAEGHEQDPLKDLVYLKEKVEAGADFVITQLFY 192
Query: 638 DTDIFLKFVNDCRQ-IGINCPIVPGIMPISNYKGFLRMAGFCKTKIPAELTAALEP-IKD 811
D + FL F R+ I + P+ PG+MPI++Y F R A IP + + P I+
Sbjct: 193 DVEKFLTFEMLFRERISQDLPLFPGLMPINSYLLFHRAAKLSHASIPPAILSRFPPEIQS 252
Query: 812 NEEAVKAFGIHFATEMCKKI---LAHGITTLHIYTLNVDKSAIGIL 940
++ AVK+ G+ E+ ++I + I H YTLN++K+ I+
Sbjct: 253 DDNAVKSIGVDILIELIQEIYQRTSGRIKGFHFYTLNLEKAIAQIV 298
>sp|O67422|METF_AQUAE 5,10-methylenetetrahydrofolate reductase OS=Aquifex
aeolicus GN=metF PE=3 SV=1
Length = 296
Score = 125 bits (312), Expect = 2e-027
Identities = 63/154 (40%), Positives = 90/154 (58%)
Frame = +2
Query: 65 KIKSATEQGQTAFSFEFFPPKTDDGVENLFERMDRLVSYGPSFCDITWGAGGSTADLTLE 244
KI +G + SFEFFPPKT++G LFE + +L P+F +T+GAGGST D T
Sbjct: 2 KIGDILRKGVFSISFEFFPPKTEEGERQLFETIRKLEKLNPTFVSVTYGAGGSTRDRTRN 61
Query: 245 IASRMQNAICVETMMHLTCTNMPVEKIDHALETIRSNGIQNVLALRGDPPHGQDKFVQVE 424
I ++ + M HLTC E++ L+ ++ GI+N+LALRGD P + + +
Sbjct: 62 IVQKIHEETNLTVMAHLTCIAHTREELIDILQDYKNIGIENILALRGDVPRDKPDWRPPK 121
Query: 425 GGFACALDLVNHIRSKYGDYFGITVAGYPEAHPD 526
G A +LV IR ++GD+F I VA YPE HP+
Sbjct: 122 GACKYAKELVELIRKEFGDWFSIGVASYPEGHPE 155
Score = 113 bits (281), Expect = 7e-024
Identities = 54/130 (41%), Positives = 76/130 (58%), Gaps = 2/130 (1%)
Frame = +2
Query: 554 PES--YQSDLAYLKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISN 727
PES + ++ Y K KV+AGAD +TQ+F+ D + +FV C+ GI+ I+PGIMPI+N
Sbjct: 154 PESPNLEWEVKYFKEKVEAGADFSITQMFFVNDYYYRFVEMCKNAGIDISIIPGIMPITN 213
Query: 728 YKGFLRMAGFCKTKIPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITTLHIYT 907
+K + A C IP L LE ++D E VK GI FA C ++ HG+ LH YT
Sbjct: 214 FKQIRKFASLCGATIPQSLIEKLEKVEDKPEEVKKIGIEFAINQCLDLIEHGVPGLHFYT 273
Query: 908 LNVDKSAIGI 937
LN + + I
Sbjct: 274 LNKSDATLKI 283
>sp|P45208|METF_HAEIN 5,10-methylenetetrahydrofolate reductase OS=Haemophilus
influenzae GN=metF PE=3 SV=1
Length = 292
Score = 101 bits (250), Expect = 3e-020
Identities = 51/133 (38%), Positives = 77/133 (57%)
Frame = +2
Query: 557 ESYQSDLAYLKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKG 736
+S Q+DL LKRK+DAGA+ ++TQ F+D + +L+F + C IGI+ IVPGI+P++N+K
Sbjct: 158 KSAQADLINLKRKIDAGANHVITQFFFDIENYLRFRDRCASIGIDTEIVPGILPVTNFKQ 217
Query: 737 FLRMAGFCKTKIPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITTLHIYTLNV 916
+MA F KIPA L A + + ++ A +M K + G+ H YTLN
Sbjct: 218 LQKMASFTNVKIPAWLVKAYDGLDNDPTTRNLVAASVAMDMVKILSREGVNDFHFYTLNR 277
Query: 917 DKSAIGILMNLGL 955
+ I LG+
Sbjct: 278 SELTYAICHMLGV 290
>sp|P0AEZ1|METF_ECOLI 5,10-methylenetetrahydrofolate reductase OS=Escherichia
coli (strain K12) GN=metF PE=1 SV=1
Length = 296
Score = 100 bits (248), Expect = 5e-020
Identities = 50/133 (37%), Positives = 77/133 (57%)
Frame = +2
Query: 557 ESYQSDLAYLKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKG 736
+S Q+DL LKRKVDAGA+ +TQ F+D + +L+F + C GI+ I+PGI+P+SN+K
Sbjct: 160 KSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQ 219
Query: 737 FLRMAGFCKTKIPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITTLHIYTLNV 916
+ A +IPA + + + D+ E K G + A +M K + G+ H YTLN
Sbjct: 220 AKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNR 279
Query: 917 DKSAIGILMNLGL 955
+ + I LG+
Sbjct: 280 AEMSYAICHTLGV 292
>sp|P0AEZ2|METF_SHIFL 5,10-methylenetetrahydrofolate reductase OS=Shigella
flexneri GN=metF PE=3 SV=1
Length = 296
Score = 100 bits (248), Expect = 5e-020
Identities = 50/133 (37%), Positives = 77/133 (57%)
Frame = +2
Query: 557 ESYQSDLAYLKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKG 736
+S Q+DL LKRKVDAGA+ +TQ F+D + +L+F + C GI+ I+PGI+P+SN+K
Sbjct: 160 KSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQ 219
Query: 737 FLRMAGFCKTKIPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITTLHIYTLNV 916
+ A +IPA + + + D+ E K G + A +M K + G+ H YTLN
Sbjct: 220 AKKFADMTNVRIPAWMAQMFDGLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNR 279
Query: 917 DKSAIGILMNLGL 955
+ + I LG+
Sbjct: 280 AEMSYAICHTLGV 292
>sp|P11003|METF_SALTY 5,10-methylenetetrahydrofolate reductase OS=Salmonella
typhimurium GN=metF PE=3 SV=2
Length = 296
Score = 99 bits (244), Expect = 1e-019
Identities = 49/133 (36%), Positives = 78/133 (58%)
Frame = +2
Query: 557 ESYQSDLAYLKRKVDAGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKG 736
+S Q+DL LKRKVDAGA+ +TQ F+D + +L+F + C GI+ I+PGI+P+SN+K
Sbjct: 160 KSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQ 219
Query: 737 FLRMAGFCKTKIPAELTAALEPIKDNEEAVKAFGIHFATEMCKKILAHGITTLHIYTLNV 916
+ A +IP+ ++ E + ++ E K G + A +M K + G+ H YTLN
Sbjct: 220 AKKFADMTNVRIPSWMSLMFEGLDNDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNR 279
Query: 917 DKSAIGILMNLGL 955
+ + I LG+
Sbjct: 280 AEMSYAICHTLGV 292
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,767,994,010
Number of Sequences: 518415
Number of Extensions: 98767994010
Number of Successful Extensions: 632508636
Number of sequences better than 0.0: 0
|
