BLASTX 7.6.2
Query= UN23483 /QuerySize=986
(985 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8L9G7|APH1_ARATH Gamma-secretase subunit APH1-like OS=Arabid... 464 6e-130
sp|Q9VQG2|APH1_DROME Gamma-secretase subunit Aph-1 OS=Drosophila... 104 2e-021
sp|Q8C7N7|APH1B_MOUSE Gamma-secretase subunit APH-1B OS=Mus musc... 96 3e-019
sp|Q8WW43|APH1B_HUMAN Gamma-secretase subunit APH-1B OS=Homo sap... 95 6e-019
sp|Q5RDM3|APH1B_PONAB Gamma-secretase subunit APH-1B OS=Pongo ab... 94 1e-018
sp|Q8JHE9|APH1B_DANRE Gamma-secretase subunit Aph-1b OS=Danio re... 91 9e-018
sp|Q9DCZ9|APH1C_MOUSE Putative gamma-secretase subunit APH-1C OS... 86 3e-016
sp|Q8BVF7|APH1A_MOUSE Gamma-secretase subunit APH-1A OS=Mus musc... 86 4e-016
sp|Q96BI3|APH1A_HUMAN Gamma-secretase subunit APH-1A OS=Homo sap... 85 8e-016
>sp|Q8L9G7|APH1_ARATH Gamma-secretase subunit APH1-like OS=Arabidopsis thaliana
GN=At2g31440 PE=2 SV=2
Length = 250
Score = 464 bits (1192), Expect = 6e-130
Identities = 229/249 (91%), Positives = 245/249 (98%)
Frame = +2
Query: 53 MTVAAGIGYALLALGPSLSLFVSVISRKPFLILTLLSSTLVWLVSLIVLSGLWRPFLPLK 232
MTVAAGIGYAL+ALGPSLSLFVSVISRKPFLILT+LSSTL+WLVSLI+LSGLWRPFLPLK
Sbjct: 1 MTVAAGIGYALVALGPSLSLFVSVISRKPFLILTVLSSTLLWLVSLIILSGLWRPFLPLK 60
Query: 233 ANVVWPYALLVLSSVCFQEALRFLFWKLYMRLEDVLDSFADRISRPRLFLTDKLQIALAG 412
ANV WPYALLV++SVCFQE LRFLFWK+Y RLEDVLDSFADRISRPRLFLTDKLQIALAG
Sbjct: 61 ANVWWPYALLVITSVCFQEGLRFLFWKVYKRLEDVLDSFADRISRPRLFLTDKLQIALAG 120
Query: 413 GLGHGVAHAVFFCLSLLTPAFGPATFYVDRCSKVPFFLISAIIALAFVTIHTFSMVIAFE 592
GLGHGVAHAVFFCLSLLTPAFGPATFYV+RCSKVPFFLISAIIALAFVTIHTFSMVIAFE
Sbjct: 121 GLGHGVAHAVFFCLSLLTPAFGPATFYVERCSKVPFFLISAIIALAFVTIHTFSMVIAFE 180
Query: 593 GYAKGNRVDQVIVPVIHLSAGMLTLVNFASEGCMIGVPLLYLVASLTLLHCGKMVWQRLI 772
GYAKGN+VDQ+IVPVIHL+AGMLTLVNFASEGC+IGVPLLYLVASLTL+HCGKMVWQRL+
Sbjct: 181 GYAKGNKVDQIIVPVIHLTAGMLTLVNFASEGCVIGVPLLYLVASLTLVHCGKMVWQRLL 240
Query: 773 ESRNQSGST 799
ESRNQS ++
Sbjct: 241 ESRNQSSAS 249
>sp|Q9VQG2|APH1_DROME Gamma-secretase subunit Aph-1 OS=Drosophila melanogaster
GN=aph-1 PE=1 SV=1
Length = 238
Score = 104 bits (257), Expect = 2e-021
Identities = 73/221 (33%), Positives = 115/221 (52%), Gaps = 13/221 (5%)
Frame = +2
Query: 74 GYALLALGPSLSLFVSVISRKPFLILTLLSSTLVWLVSLIVLSGLWRPFLPLKANVVWPY 253
G +A GP +LFV I+ P I+ L+++ WL+SL++ S LW +PLK +
Sbjct: 8 GCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLI-SSLWYALIPLKEFL---- 62
Query: 254 ALLVLSSVCFQEALRFLFWKLYMRLEDVLDSFADRISRPRLFLTDKLQI-ALAGGLGHGV 430
A V+ SVCFQEA R++ +++ E L + A+ +TD I A GLG G+
Sbjct: 63 AFGVVFSVCFQEAFRYIIYRILRSTEQGLHAVAEDTR-----VTDNKHILAYVSGLGFGI 117
Query: 431 AHAVFFCLSLLTPAFGPATFYVDRCSKVPFFLISAIIALAFVTIHTFSMVIAFEGYAKGN 610
+F +++L GP T + +++ FF+ SA AL+ + +HTF VI F + N
Sbjct: 118 ISGMFALVNVLADMSGPGTMGLKGGTEL-FFVTSAAQALSIILLHTFWSVIFFNAFDTNN 176
Query: 611 RVDQVIVPVIHLSAGMLTLVNFASEGCMIGVPLLYLVASLT 733
+ V HL ++TL+N A+E + + YLV LT
Sbjct: 177 YIHIGYVVFSHLFVSLITLLN-ANELYTTTLLINYLVTILT 216
>sp|Q8C7N7|APH1B_MOUSE Gamma-secretase subunit APH-1B OS=Mus musculus GN=Aph1b
PE=2 SV=1
Length = 257
Score = 96 bits (238), Expect = 3e-019
Identities = 67/212 (31%), Positives = 102/212 (48%), Gaps = 11/212 (5%)
Frame = +2
Query: 53 MTVAAGIGYALLALGPSLSLFVSVISRKPFLILTLLSSTLVWLVSLIVLSGLW---RPFL 223
MT A G A +A GP+L+L+V I+ P ++ L++ WLVSL++ S W R
Sbjct: 1 MTAAVFFGCAFIAFGPALALYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVIT 60
Query: 224 PLKANVVWPYALL--VLSSVCFQEALRFLFWKLYMRLEDVLDSFADRISRPRLFLTDKLQ 397
+ V Y L+ VL SVC QE R ++KL + + L S + P + L
Sbjct: 61 DNRDGPVQNYLLIFGVLLSVCIQELFRLAYYKLLKKASEGLKSINPEETAPSMRL----- 115
Query: 398 IALAGGLGHGVAHAVFFCLSLLTPAFGPATFYVDRCSKVPFFLISAIIALAFVTIHTFSM 577
+A GLG G+ VF ++ L+ + GP T + S FFL SA + L + +H F
Sbjct: 116 LAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSP-QFFLNSAFMTLVVIMLHVFWG 174
Query: 578 VIAFEGYAKGNRVDQVIVPVIHLSAGMLTLVN 673
V+ F+G K + V + HL T ++
Sbjct: 175 VVFFDGCEKNKWYTLLTVLLTHLVVSTQTFLS 206
>sp|Q8WW43|APH1B_HUMAN Gamma-secretase subunit APH-1B OS=Homo sapiens GN=APH1B
PE=1 SV=3
Length = 257
Score = 95 bits (235), Expect = 6e-019
Identities = 66/212 (31%), Positives = 103/212 (48%), Gaps = 11/212 (5%)
Frame = +2
Query: 53 MTVAAGIGYALLALGPSLSLFVSVISRKPFLILTLLSSTLVWLVSLIVLSGLW---RPFL 223
MT A G A +A GP+L+L+V I+ +P I+ L++ WLVSL++ S +W R +
Sbjct: 1 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII 60
Query: 224 PLKANVVWPYALL--VLSSVCFQEALRFLFWKLYMRLEDVLDSFADRISRPRLFLTDKLQ 397
K Y L+ SV QE RF ++KL + + L S + P + L
Sbjct: 61 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRL----- 115
Query: 398 IALAGGLGHGVAHAVFFCLSLLTPAFGPATFYVDRCSKVPFFLISAIIALAFVTIHTFSM 577
+A GLG G+ VF ++ L+ + GP T + S FFL SA + L + +H F
Sbjct: 116 LAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSP-QFFLYSAFMTLVIILLHVFWG 174
Query: 578 VIAFEGYAKGNRVDQVIVPVIHLSAGMLTLVN 673
++ F+G K +IV + HL T ++
Sbjct: 175 IVFFDGCEKKKWGILLIVLLTHLLVSAQTFIS 206
>sp|Q5RDM3|APH1B_PONAB Gamma-secretase subunit APH-1B OS=Pongo abelii GN=APH1B
PE=2 SV=1
Length = 257
Score = 94 bits (232), Expect = 1e-018
Identities = 65/212 (30%), Positives = 103/212 (48%), Gaps = 11/212 (5%)
Frame = +2
Query: 53 MTVAAGIGYALLALGPSLSLFVSVISRKPFLILTLLSSTLVWLVSLIVLSGLW---RPFL 223
MT A G A +A GP+L+L+V I+ +P I+ L++ WLVSL++ S +W R +
Sbjct: 1 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII 60
Query: 224 PLKANVVWPYALL--VLSSVCFQEALRFLFWKLYMRLEDVLDSFADRISRPRLFLTDKLQ 397
K Y L+ SV QE RF +++L + + L S + P + L
Sbjct: 61 DNKDGPTQKYLLIFGTFVSVYIQEMFRFAYYRLLKKASEGLKSINPGETAPSMRL----- 115
Query: 398 IALAGGLGHGVAHAVFFCLSLLTPAFGPATFYVDRCSKVPFFLISAIIALAFVTIHTFSM 577
+A GLG G+ VF ++ L+ + GP T + S FFL SA + L + +H F
Sbjct: 116 LAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSP-QFFLYSAFMTLVIILLHVFWG 174
Query: 578 VIAFEGYAKGNRVDQVIVPVIHLSAGMLTLVN 673
++ F+G K +IV + HL T ++
Sbjct: 175 IVFFDGCEKKKWGILLIVLLTHLLVSAQTFIS 206
>sp|Q8JHE9|APH1B_DANRE Gamma-secretase subunit Aph-1b OS=Danio rerio GN=aph1b
PE=2 SV=1
Length = 258
Score = 91 bits (225), Expect = 9e-018
Identities = 67/236 (28%), Positives = 114/236 (48%), Gaps = 10/236 (4%)
Frame = +2
Query: 53 MTVAAGIGYALLALGPSLSLFVSVISRKPFLILTLLSSTLVWLVSLIVLSGLWRPFLPL- 229
MTVA G +A GP+++LF+ I+R P ++ L++ WLVSL++ S +W + +
Sbjct: 1 MTVAVFFGCTFIAFGPAIALFMFTIARDPLRVIFLIAGAFFWLVSLLLSSLVWFITVQIS 60
Query: 230 -KANVVWPYALL---VLSSVCFQEALRFLFWKLYMRLEDVLDSFADRISRPRLFLTDKLQ 397
K + LL V+ SV QEA R+ +++L + + L + + + P Q
Sbjct: 61 NKNSATQQRGLLIFGVVLSVLLQEAFRYGYYRLLKKANEGLLALSQEDTMP----ISMRQ 116
Query: 398 IALAGGLGHGVAHAVFFCLSLLTPAFGPATFYVDRCSKVPFFLISAIIALAFVTIHTFSM 577
+A GLG G F +++L+ + GP T + S+ +F+ SA + LA + +H F
Sbjct: 117 LAYVSGLGFGFMSGAFSVVNILSDSLGPGTVGIHGESQ-HYFISSAFMTLAIILLHMFWG 175
Query: 578 VIAFEGYAKGNRVDQVIVPVIHLSAGMLTLVNFASEGCMIGVPLLYLVASLTLLHC 745
V+ FE + V HL LT VN +G +I ++ V ++ C
Sbjct: 176 VVFFEACERQRWWALGAVVASHLVVSCLTFVNPHYQGSLIPTYIILSVMAVWAYLC 231
>sp|Q9DCZ9|APH1C_MOUSE Putative gamma-secretase subunit APH-1C OS=Mus musculus
GN=Aph1c PE=2 SV=1
Length = 258
Score = 86 bits (212), Expect = 3e-016
Identities = 62/213 (29%), Positives = 100/213 (46%), Gaps = 12/213 (5%)
Frame = +2
Query: 53 MTVAAGIGYALLALGPSLSLFVSVISRKPFLILTLLSSTLVWLVSLIVLSGLW---RPFL 223
MT+ G A +A GP+ +L++ I+ P ++ L++ WLVSL++ S W R
Sbjct: 1 MTLPVFFGCAFIAFGPAFALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSMFWFLVRVIT 60
Query: 224 PLKANVVWPYALL--VLSSVCFQEALRFLFWKLYMRLEDVLDSFADRISRPRLFLTDKLQ 397
+ V Y L+ L SVC QE R ++KL + + L S P + ++
Sbjct: 61 NNRDESVQNYLLIFGALLSVCIQELFRLAYYKLLKKASEGLKSI-----NPEEDIAPSMR 115
Query: 398 -IALAGGLGHGVAHAVFFCLSLLTPAFGPATFYVDRCSKVPFFLISAIIALAFVTIHTFS 574
+A GLG G+ VF ++ L+ + GP T + S FFL SA + L + +H F
Sbjct: 116 LLAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSP-QFFLNSAFMTLVVIMLHVFW 174
Query: 575 MVIAFEGYAKGNRVDQVIVPVIHLSAGMLTLVN 673
V+ F+G K + V + HL T ++
Sbjct: 175 GVVFFDGCEKNKWYTLLTVLLTHLVVSTQTFLS 207
>sp|Q8BVF7|APH1A_MOUSE Gamma-secretase subunit APH-1A OS=Mus musculus GN=Aph1a
PE=2 SV=2
Length = 265
Score = 86 bits (211), Expect = 4e-016
Identities = 64/233 (27%), Positives = 109/233 (46%), Gaps = 12/233 (5%)
Frame = +2
Query: 53 MTVAAGIGYALLALGPSLSLFVSVISRKPFLILTLLSSTLVWLVSLIVLSGLWRPFLPL- 229
M A G +A GP+ SLF+ ++ P ++ L++ WLVSL++ S +W + +
Sbjct: 1 MGAAVFFGCTFVAFGPAFSLFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60
Query: 230 -KANVVWPYALLVLS---SVCFQEALRFLFWKLYMRLEDVLDSFADRISRPRLFLTDKLQ 397
+++ Y LL+ SV QE RF ++KL + ++ L S ++ P Q
Sbjct: 61 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSP----ISIRQ 116
Query: 398 IALAGGLGHGVAHAVFFCLSLLTPAFGPATFYVDRCSKVPFFLISAIIALAFVTIHTFSM 577
+A GL G+ VF +++L A GP + S +FL SA + A + +HTF
Sbjct: 117 MAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPY-YFLTSAFLTAAIILLHTFWG 175
Query: 578 VIAFEGYAKGNRVDQVIVPVIHLSAGMLTLVNFASEGCMIGVPLLYLVASLTL 736
V+ F+ + +V HL LT +N E ++ P+ + S+ L
Sbjct: 176 VVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLL--PIYAVTVSMGL 226
>sp|Q96BI3|APH1A_HUMAN Gamma-secretase subunit APH-1A OS=Homo sapiens GN=APH1A
PE=1 SV=1
Length = 265
Score = 85 bits (208), Expect = 8e-016
Identities = 63/233 (27%), Positives = 109/233 (46%), Gaps = 12/233 (5%)
Frame = +2
Query: 53 MTVAAGIGYALLALGPSLSLFVSVISRKPFLILTLLSSTLVWLVSLIVLSGLWRPFLPL- 229
M A G +A GP+ +LF+ ++ P ++ L++ WLVSL++ S +W + +
Sbjct: 1 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60
Query: 230 -KANVVWPYALLVLS---SVCFQEALRFLFWKLYMRLEDVLDSFADRISRPRLFLTDKLQ 397
+++ Y LL+ SV QE RF ++KL + ++ L S ++ P Q
Sbjct: 61 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSP----ISIRQ 116
Query: 398 IALAGGLGHGVAHAVFFCLSLLTPAFGPATFYVDRCSKVPFFLISAIIALAFVTIHTFSM 577
+A GL G+ VF +++L A GP + S +FL SA + A + +HTF
Sbjct: 117 MAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPY-YFLTSAFLTAAIILLHTFWG 175
Query: 578 VIAFEGYAKGNRVDQVIVPVIHLSAGMLTLVNFASEGCMIGVPLLYLVASLTL 736
V+ F+ + +V HL LT +N E ++ P+ + S+ L
Sbjct: 176 VVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLL--PIYAVTVSMGL 226
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,767,994,010
Number of Sequences: 518415
Number of Extensions: 98767994010
Number of Successful Extensions: 632508636
Number of sequences better than 0.0: 0
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