BLASTX 7.6.2
Query= UN23967 /QuerySize=1604
(1603 letters)
Database: UniProt/SwissProt;
518,415 sequences; 182,829,261 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q4V8B1|S36A3_RAT Proton-coupled amino acid transporter 3 OS=R... 170 4e-041
sp|Q4KL91|S36A4_XENLA Proton-coupled amino acid transporter 4 OS... 163 3e-039
sp|Q811P0|S36A3_MOUSE Proton-coupled amino acid transporter 3 OS... 136 6e-031
sp|Q7Z2H8|S36A1_HUMAN Proton-coupled amino acid transporter 1 OS... 120 4e-026
sp|Q8K4D3|S36A1_MOUSE Proton-coupled amino acid transporter 1 OS... 120 4e-026
sp|Q495N2|S36A3_HUMAN Proton-coupled amino acid transporter 3 OS... 119 6e-026
sp|Q924A5|S36A1_RAT Proton-coupled amino acid transporter 1 OS=R... 114 2e-024
sp|Q8BHK3|S36A2_MOUSE Proton-coupled amino acid transporter 2 OS... 108 1e-022
sp|Q8K415|S36A2_RAT Proton-coupled amino acid transporter 2 OS=R... 107 3e-022
sp|Q495M3|S36A2_HUMAN Proton-coupled amino acid transporter 2 OS... 102 9e-021
sp|Q6YBV0|S36A4_HUMAN Proton-coupled amino acid transporter 4 OS... 80 5e-014
sp|P50944|AVT4_YEAST Vacuolar amino acid transporter 4 OS=Saccha... 77 2e-013
sp|Q8CH36|S36A4_MOUSE Proton-coupled amino acid transporter 4 OS... 76 7e-013
sp|Q9H598|VIAAT_HUMAN Vesicular inhibitory amino acid transporte... 56 6e-007
sp|Q95KE2|VIAAT_MACFA Vesicular inhibitory amino acid transporte... 56 6e-007
sp|O35633|VIAAT_MOUSE Vesicular inhibitory amino acid transporte... 56 6e-007
sp|O35458|VIAAT_RAT Vesicular inhibitory amino acid transporter ... 56 6e-007
sp|Q6DIV6|VIAAT_XENTR Vesicular inhibitory amino acid transporte... 56 6e-007
sp|Q6PF45|VIAAT_XENLA Vesicular inhibitory amino acid transporte... 56 8e-007
sp|P34579|UNC47_CAEEL Vesicular GABA transporter OS=Caenorhabdit... 55 1e-006
>sp|Q4V8B1|S36A3_RAT Proton-coupled amino acid transporter 3 OS=Rattus
norvegicus GN=Slc36a3 PE=2 SV=1
Length = 477
Score = 170 bits (429), Expect = 4e-041
Identities = 133/448 (29%), Positives = 205/448 (45%), Gaps = 28/448 (6%)
Frame = -2
Query: 1515 KQASSSSSSSSYTLKMPPPSREDTPLLGKGPPLSSQFKTFANIFIAVVGAGVLGLPYAFK 1336
K +SSSSS+++ + K P + D + + F ++ + +G G LGLP A K
Sbjct: 26 KGSSSSSSNNTVSSKKKPRRKADALMF---------IQIFIHLLKSNIGTGFLGLPLAVK 76
Query: 1335 RTGWLMGVLLLLSVSLLTHHCMMLLVYTRRKLDSLNGGGFSKIGSFGDLGFAVCGS---- 1168
G L+G + LL++ LT HCM +L+ L S F C S
Sbjct: 77 NAGLLVGPVSLLAIGALTVHCMDILLNCACHLTSRLQRSFVNYEETTMYSLETCPSPWLR 136
Query: 1167 ----LGRLVVDLFIILSQAGFCVGYLIFIGTTLANLFDPDSPTSLRHQFTRLGSEFLGVS 1000
GR VV +I++Q GFC Y +F+ L + + TS Q R +
Sbjct: 137 THSVWGRYVVSFLLIVTQLGFCSVYFMFMADNLQQIVEEAHFTSNVCQ-PRQSLVMTSIL 195
Query: 999 SKSLYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPDVVA 820
Y+ PF + L ++ L+ S A + L+++A++ + +I + +
Sbjct: 196 DTRFYMLTILPFLILLVLVQNPQVLSIFSTLATITTLSSLALIF--EYLIQIPHHSHLPL 253
Query: 819 FGGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGY 640
F G A+++FEGVGMVLPL+S+MK +F VL LGM F+ F+YI G LGY
Sbjct: 254 VASWKTFLLFFGTAIFTFEGVGMVLPLKSQMKSPQQFPAVLYLGMSFVIFLYICLGTLGY 313
Query: 639 LAFGEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEI----VERRFSGG-- 478
+ FG DT IT NL + V+L + +FFT+ L + EI V R S
Sbjct: 314 MKFGADTQASITLNLPNCWLYQSVKLMYSVGIFFTYALQFHVPAEIIVPYVVSRASENWA 373
Query: 477 -MYSACLRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVF-KEEMGW 304
+R LV A+ +P +SLVGS + L ++P L + F E +
Sbjct: 374 LFIDLTVRAALVCLTCFSAVLIPRLDLVISLVGSVSSSALALIIPPLLEIATFYSENISC 433
Query: 303 KQWSLDMAIVGLGVVLAVSGTWSSLSEI 220
+ D+ I LG++ V GT+ +L E+
Sbjct: 434 TTIAKDIMISILGLLGCVLGTYQALYEM 461
>sp|Q4KL91|S36A4_XENLA Proton-coupled amino acid transporter 4 OS=Xenopus laevis
GN=slc36a4 PE=2 SV=1
Length = 522
Score = 163 bits (412), Expect = 3e-039
Identities = 118/417 (28%), Positives = 203/417 (48%), Gaps = 32/417 (7%)
Frame = -2
Query: 1407 FKTFANIFIAVVGAGVLGLPYAFKRTGWLMGVLLLLSVSLLTHHCMMLLV----YTRRKL 1240
F+T ++ +G G+LGLP A K G L+G + LL +++ HCM +LV + ++
Sbjct: 90 FQTLIHLLKGNIGTGLLGLPLAMKNAGVLLGPISLLFFGIISIHCMNILVRCSHFLCQRY 149
Query: 1239 DSLNGGGFSKIGSFGDLGFAVC---GSLGRLVVDLFIILSQAGFCVGYLIFIGTTLANLF 1069
N G +G ++G V S GR +VD F++++Q GFC Y +F+ + +F
Sbjct: 150 KKANLGYSDTVGLALEVGPGVLQRHASFGRNLVDWFLVVTQLGFCSVYFVFLAENIKQVF 209
Query: 1068 DPDSPTSLRHQFTRLGSEFLGVSSKSLYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDL 889
+ T L+ + S L +Y++ P + L I+ L +L+ LS FA++
Sbjct: 210 EVFLETKLQQSEIGIWSLDL-----RIYMFSFLPLIIPLVFIRDLKNLSLLSFFANV--S 262
Query: 888 AAMAVVIVEDSMIILKQRPDVVAFG----GMSLFFYGMGVAVYSFEGVGMVLPLESEMKD 721
A++++IV +I P + G LFF G A+++FEG+G+VLPLE+ M+D
Sbjct: 263 MAISLLIVYQYVIRNLSDPRTLPLGTSWKTYPLFF---GTAIFAFEGIGVVLPLENRMRD 319
Query: 720 KDKFGKVLALGMGFISFIYIAFGFLGYLAFGEDTMDIITANLGAG-----LISTIVQLGL 556
K F K L +GM ++ +YI+ LGY FG+ IT NL L+ + G+
Sbjct: 320 KKDFSKALNIGMAIVTTLYISLATLGYFCFGDQIKGSITLNLPQDSWLYQLVKILYSFGI 379
Query: 555 CINLFFTFPLMMNPVFEIVERRFSGGMYSAC---LRWLLVLAVTLVALFVPNFTDFLSLV 385
+ + + + V R C +R+ LV VA+ +P +S V
Sbjct: 380 YVTYAIQYYVPAEIILPAVTSRVQKTRKLLCEFTMRFFLVCLTCAVAVLIPRLDLVISFV 439
Query: 384 GSSTCCILGFVLPALFHLLVFKEEMGWKQWSL--DMAIVGLGVVLAVSGTWSSLSEI 220
G+ + L +LP L ++ + +E W + D+ I +G V ++GT+ ++ E+
Sbjct: 440 GAVSSSTLALILPPLVEIITYHKE-NLSPWVIMKDVGIAVIGFVGFIAGTYVTIEEM 495
>sp|Q811P0|S36A3_MOUSE Proton-coupled amino acid transporter 3 OS=Mus musculus
GN=Slc36a3 PE=2 SV=1
Length = 477
Score = 136 bits (341), Expect = 6e-031
Identities = 100/323 (30%), Positives = 152/323 (47%), Gaps = 11/323 (3%)
Frame = -2
Query: 1164 GRLVVDLFIILSQAGFCVGYLIFIGTTLANLFDPDSPTSLRHQFTRLGSEFLGVSSKSLY 985
GR VV +I++Q GFC Y +F+ L + + TS Q R + Y
Sbjct: 142 GRYVVSFLLIVTQLGFCSVYFMFLADNLQQIMEEAHFTSNVCQ-PRQSLVMTSILDTRFY 200
Query: 984 IWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPDVVAFGGMS 805
+ PF + L I+ L+ S A + L+++A++ + +I ++
Sbjct: 201 MLTILPFLILLVLIQNPQVLSIFSTLATITTLSSLALIF--EYLIQTPHHSNLPLVANWK 258
Query: 804 LFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGYLAFGE 625
F G A+++FEGVGMVLPL+S+MK +F VL LGM F+ F+YI G LGY+ FG
Sbjct: 259 TFLLFFGTAIFTFEGVGMVLPLKSQMKSPQQFPAVLYLGMSFVIFLYICLGTLGYMKFGT 318
Query: 624 DTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEI----VERRFSGG---MYSA 466
DT IT NL + V+L + +FFT+ L + EI V R S
Sbjct: 319 DTQASITLNLPICWLYQSVKLMYSVGIFFTYALQFHVPAEIIVPYVVSRVSENWALFVDL 378
Query: 465 CLRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVF-KEEMGWKQWSL 289
+R LV A+ +P +SLVGS + L ++P L + F E +
Sbjct: 379 TVRTALVCLTCFSAVLIPRLDLVISLVGSVSSSALAIIIPPLLEIATFYSENISCATIVK 438
Query: 288 DMAIVGLGVVLAVSGTWSSLSEI 220
D+ I LG++ V GT+ +L E+
Sbjct: 439 DIMISILGLLGCVLGTYQALYEM 461
>sp|Q7Z2H8|S36A1_HUMAN Proton-coupled amino acid transporter 1 OS=Homo sapiens
GN=SLC36A1 PE=1 SV=1
Length = 476
Score = 120 bits (299), Expect = 4e-026
Identities = 90/272 (33%), Positives = 137/272 (50%), Gaps = 23/272 (8%)
Frame = -2
Query: 990 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPD------ 829
LY+ PF + L I+ L L+ S+ A++ L ++ ++ I+++ PD
Sbjct: 196 LYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIY----QFIVQRIPDPSHLPL 251
Query: 828 VVAFGGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGF 649
V + LFF G A++SFEG+GMVLPLE++MKD KF +L LGM ++ +YI+ G
Sbjct: 252 VAPWKTYPLFF---GTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISLGC 308
Query: 648 LGYLAFGEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEIVERRFSGGMYS 469
LGYL FG + IT NL + V+L I +FFT+ L EI+ F
Sbjct: 309 LGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPE 368
Query: 468 AC-------LRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEM 310
C +R +LV ++A+ +P +SLVGS + L ++P L + F E
Sbjct: 369 HCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSE- 427
Query: 309 GWKQWSL--DMAIVGLGVVLAVSGTWSSLSEI 220
G ++ D I LG V V GT+ +L E+
Sbjct: 428 GMSPLTIFKDALISILGFVGFVVGTYEALYEL 459
>sp|Q8K4D3|S36A1_MOUSE Proton-coupled amino acid transporter 1 OS=Mus musculus
GN=Slc36a1 PE=2 SV=1
Length = 475
Score = 120 bits (299), Expect = 4e-026
Identities = 88/271 (32%), Positives = 137/271 (50%), Gaps = 21/271 (7%)
Frame = -2
Query: 990 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPD------ 829
LY+ PF + L+ I+ L L+ S+ A++ +M V ++ I+++ PD
Sbjct: 195 LYMLSFLPFLVLLSFIRNLRVLSIFSLLANI----SMFVSLIMIYQFIVQRIPDPSHLPL 250
Query: 828 VVAFGGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGF 649
V + LFF G A+++FEG+G+VLPLE++MKD KF +L LGM I+ +YI+ G
Sbjct: 251 VAPWKTYPLFF---GTAIFAFEGIGVVLPLENKMKDSQKFPLILYLGMAIITVLYISLGS 307
Query: 648 LGYLAFGEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEIVERRFSGG--- 478
LGYL FG + IT NL + V+L I +FFT+ L EI+
Sbjct: 308 LGYLQFGANIKGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVAAEIIIPAIVSRVPE 367
Query: 477 ----MYSACLRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLV-FKEE 313
M C+R +V ++A+ +P +SLVGS + L ++P L ++ + E
Sbjct: 368 HFELMVDLCVRTAMVCVTCVLAILIPRLDLVISLVGSVSSSALALIIPPLLEVVTYYGEG 427
Query: 312 MGWKQWSLDMAIVGLGVVLAVSGTWSSLSEI 220
+ + D I LG V V GT+ SL E+
Sbjct: 428 ISPLTVTKDALISILGFVGFVVGTYESLCEL 458
>sp|Q495N2|S36A3_HUMAN Proton-coupled amino acid transporter 3 OS=Homo sapiens
GN=SLC36A3 PE=1 SV=2
Length = 470
Score = 119 bits (298), Expect = 6e-026
Identities = 84/264 (31%), Positives = 135/264 (51%), Gaps = 9/264 (3%)
Frame = -2
Query: 987 YIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPDVVAFGGM 808
Y+ PF + L I+ L L+ S A++ L +MA +I E M + ++
Sbjct: 192 YMLIILPFLILLVFIQNLKVLSVFSTLANITTLGSMA-LIFEYIMEGIPYPSNLPLMANW 250
Query: 807 SLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGYLAFG 628
F G A+++FEGVGMVLPL+++MK +F VL LGM + +YI G LGY+ FG
Sbjct: 251 KTFLLFFGTAIFTFEGVGMVLPLKNQMKHPQQFSFVLYLGMSIVIILYILLGTLGYMKFG 310
Query: 627 EDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEIV------ERRFSGGMY-S 469
DT IT NL + V+L I +FFT+ L + EI+ + S ++
Sbjct: 311 SDTQASITLNLPNCWLYQSVKLMYSIGIFFTYALQFHVPAEIIIPFAISQVSESWALFVD 370
Query: 468 ACLRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVF-KEEMGWKQWS 292
+R LV + A+ +P +SLVGS + L ++PAL +++F E+M +
Sbjct: 371 LSVRSALVCLTCVSAILIPRLDLVISLVGSVSSSALALIIPALLEIVIFYSEDMSCVTIA 430
Query: 291 LDMAIVGLGVVLAVSGTWSSLSEI 220
D+ I +G++ + GT+ +L E+
Sbjct: 431 KDIMISIVGLLGCIFGTYQALYEL 454
>sp|Q924A5|S36A1_RAT Proton-coupled amino acid transporter 1 OS=Rattus
norvegicus GN=Slc36a1 PE=2 SV=1
Length = 475
Score = 114 bits (285), Expect = 2e-024
Identities = 90/272 (33%), Positives = 136/272 (50%), Gaps = 23/272 (8%)
Frame = -2
Query: 990 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPD------ 829
LY+ PF + L+ I+ L L+ S+ A++ +M V ++ I+++ PD
Sbjct: 195 LYMLTFLPFLVLLSFIRNLRILSIFSLLANI----SMFVSLIMIYQFIVQRIPDPSHLPL 250
Query: 828 VVAFGGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGF 649
V + LFF G A+++FEG+G+VLPLE++MKD KF +L LGM I+ +YI+ G
Sbjct: 251 VAPWKTYPLFF---GTAIFAFEGIGVVLPLENKMKDSQKFPLILYLGMAIITVLYISLGS 307
Query: 648 LGYLAFGEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEI--------VER 493
LGYL FG D IT NL + V+L I +FFT+ L EI V
Sbjct: 308 LGYLQFGADIKGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVAAEIIIPAIVSRVPE 367
Query: 492 RFSGGMYSACLRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLV-FKE 316
RF + R +V ++A+ +P +SLVGS + L ++P L + + E
Sbjct: 368 RFE-LVVDLSARTAMVCVTCVLAVLIPRLDLVISLVGSVSSSALALIIPPLLEVTTYYGE 426
Query: 315 EMGWKQWSLDMAIVGLGVVLAVSGTWSSLSEI 220
+ + D I LG V V GT+ SL E+
Sbjct: 427 GISPLTITKDALISILGFVGFVVGTYESLWEL 458
>sp|Q8BHK3|S36A2_MOUSE Proton-coupled amino acid transporter 2 OS=Mus musculus
GN=Slc36a2 PE=1 SV=1
Length = 478
Score = 108 bits (269), Expect = 1e-022
Identities = 84/266 (31%), Positives = 132/266 (49%), Gaps = 17/266 (6%)
Frame = -2
Query: 990 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPDVVAFGG 811
L + G F L + + LA +S+ LV +A + + D+ Q P V ++
Sbjct: 204 LPVLGLLVFVRNLRVLTIFSLLANISMLVSLVIIAQYIIQEIPDA----SQLPLVASWKT 259
Query: 810 MSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGYLAF 631
LFF G A++SFE +G+VLPLE++MKD F +L+LGM I+ +YIA G LGYL F
Sbjct: 260 YPLFF---GTAIFSFESIGVVLPLENKMKDARGFPTILSLGMSIITTLYIAIGALGYLRF 316
Query: 630 GEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEI--------VERRFSGGM 475
G+D IT NL + V+L + + T+ L EI V +R++ +
Sbjct: 317 GDDIKASITLNLPNCWLYQSVKLLYVVGILCTYALQFYVPAEIIIPLAVSQVSKRWALPV 376
Query: 474 YSACLRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLV-FKEEMGWKQ 298
+R LV ++A+ +P LSLVGS + L ++P L ++ + E +
Sbjct: 377 -DLSIRLALVCLTCMLAILIPRLDLVLSLVGSVSSSALALIIPPLLEVVTYYGEGISPLT 435
Query: 297 WSLDMAIVGLGVVLAVSGTWSSLSEI 220
+ D I LG + V GT+ +L E+
Sbjct: 436 VTKDALISILGFMGFVVGTYQALDEL 461
>sp|Q8K415|S36A2_RAT Proton-coupled amino acid transporter 2 OS=Rattus
norvegicus GN=Slc36a2 PE=1 SV=1
Length = 481
Score = 107 bits (266), Expect = 3e-022
Identities = 87/271 (32%), Positives = 137/271 (50%), Gaps = 21/271 (7%)
Frame = -2
Query: 990 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIIL-----KQRPDV 826
LY+ P LGL + + +L L+IF+ L +++ + +++ II Q P V
Sbjct: 201 LYMLAFLPV-LGL--LVFIRNLRVLTIFSLLANVSMLVSLVIIGQYIIQGIPDPSQLPLV 257
Query: 825 VAFGGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFL 646
++ LFF G A++SFE +G+VLPLE++MKD +F +L+LGM I+ +YIA G L
Sbjct: 258 ASWKTYPLFF---GTAIFSFESIGVVLPLENKMKDARRFPTILSLGMSIITTLYIAIGAL 314
Query: 645 GYLAFGEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEI--------VERR 490
GYL FG+D IT NL + V+L + + T L EI V +R
Sbjct: 315 GYLRFGDDIKASITLNLPNCWLYQSVKLLYVVGILCTHALQFYVPAEIIIPLAVSQVSKR 374
Query: 489 FSGGMYSACLRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLV-FKEE 313
++ + +R LV ++A+ +P LSLVGS + L ++P L + + E
Sbjct: 375 WALPV-DLSIRLALVCVTCMLAILIPRLDLVLSLVGSVSSSALALIIPPLLEVTTYYGEG 433
Query: 312 MGWKQWSLDMAIVGLGVVLAVSGTWSSLSEI 220
M + D I LG + V GT+ +L E+
Sbjct: 434 MSPLTITKDALISILGFMGFVVGTYQALDEL 464
>sp|Q495M3|S36A2_HUMAN Proton-coupled amino acid transporter 2 OS=Homo sapiens
GN=SLC36A2 PE=2 SV=1
Length = 483
Score = 102 bits (253), Expect = 9e-021
Identities = 81/269 (30%), Positives = 133/269 (49%), Gaps = 17/269 (6%)
Frame = -2
Query: 990 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVI--VEDSMIILKQRPDVVAF 817
LY+ PF + L I+ L L S+ A++ L ++ ++I + + + P V ++
Sbjct: 203 LYMLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRLPLVASW 262
Query: 816 GGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGYL 637
LFF G A++SFE +G+VLPLE++MK+ F +L+LGM ++ +YI LGYL
Sbjct: 263 KTYPLFF---GTAIFSFESIGVVLPLENKMKNARHFPAILSLGMSIVTSLYIGMAALGYL 319
Query: 636 AFGEDTMDIITANLGAGLISTIVQLGLCINLFFTFPLMMNPVFEI--------VERRFSG 481
FG+D I+ NL + V+L + T+ L EI V R++
Sbjct: 320 RFGDDIKASISLNLPNCWLYQSVKLLYIAGILCTYALQFYVPAEIIIPFAISRVSTRWAL 379
Query: 480 GMYSACLRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWK 301
+ +R ++V L+A+ +P +SLVGS + L ++P L + F E G
Sbjct: 380 PL-DLSIRLVMVCLTCLLAILIPRLDLVISLVGSVSGTALALIIPPLLEVTTFYSE-GMS 437
Query: 300 QWSL--DMAIVGLGVVLAVSGTWSSLSEI 220
++ D I LG V V GT+ +L E+
Sbjct: 438 PLTIFKDALISILGFVGFVVGTYQALDEL 466
>sp|Q6YBV0|S36A4_HUMAN Proton-coupled amino acid transporter 4 OS=Homo sapiens
GN=SLC36A4 PE=2 SV=1
Length = 504
Score = 80 bits (195), Expect = 5e-014
Identities = 53/171 (30%), Positives = 91/171 (53%), Gaps = 14/171 (8%)
Frame = -2
Query: 990 LYIWGCFPFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPD------ 829
+Y+ PF + L I+ L +L LS A++ +MAV +V +++ PD
Sbjct: 211 IYMLCFLPFIILLVFIRELKNLFVLSFLANV----SMAVSLVIIYQYVVRNMPDPHNLPI 266
Query: 828 VVAFGGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGF 649
V + LFF G AV++FEG+G+VLPLE++MK+ +F + L +GMG ++ +Y+
Sbjct: 267 VAGWKKYPLFF---GTAVFAFEGIGVVLPLENQMKESKRFPQALNIGMGIVTTLYVTLAT 323
Query: 648 LGYLAFGEDTMDIITANLGAGL-ISTIVQLGLCINLFFTFPLMMNPVFEIV 499
LGY+ F ++ IT NL + + V++ +F T+ + EI+
Sbjct: 324 LGYMCFHDEIKGSITLNLPQDVWLYQSVKILYSFGIFVTYSIQFYVPAEII 374
>sp|P50944|AVT4_YEAST Vacuolar amino acid transporter 4 OS=Saccharomyces
cerevisiae GN=AVT4 PE=1 SV=1
Length = 713
Score = 77 bits (189), Expect = 2e-013
Identities = 43/162 (26%), Positives = 88/162 (54%), Gaps = 6/162 (3%)
Frame = -2
Query: 954 LNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPDVVAFG-----GMSLFFYG 790
L+ I+ ++ L+ S+ A+ +A + +VI+ + + A G +
Sbjct: 428 LSFIRNISKLSLPSLLANFFIMAGLVIVIIFTAKRLFFDLMGTPAMGVVYGLNADRWTLF 487
Query: 789 MGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGYLAFGEDTMDI 610
+G A+++FEG+G+++P++ M++ +KF VLAL + + ++I+ LGYLA+G + +
Sbjct: 488 IGTAIFAFEGIGLIIPVQDSMRNPEKFPLVLALVILTATILFISIATLGYLAYGSNVQTV 547
Query: 609 ITANL-GAGLISTIVQLGLCINLFFTFPLMMNPVFEIVERRF 487
I NL + + ++QL I + + PL + P +I+E +F
Sbjct: 548 ILLNLPQSNIFVNLIQLFYSIAIMLSTPLQLFPAIKIIENKF 589
>sp|Q8CH36|S36A4_MOUSE Proton-coupled amino acid transporter 4 OS=Mus musculus
GN=Slc36a4 PE=2 SV=1
Length = 500
Score = 76 bits (185), Expect = 7e-013
Identities = 52/167 (31%), Positives = 90/167 (53%), Gaps = 15/167 (8%)
Frame = -2
Query: 975 CF-PFQLGLNSIKTLTHLAPLSIFADLVDLAAMAVVIVEDSMIILKQRPD------VVAF 817
CF P + L I+ L +L LS A+ + +AA V+I + +++ PD V +
Sbjct: 212 CFLPLIILLVFIRELKNLFVLSFLAN-ISMAASLVIIYQ---YVVRNMPDPHNLPIVAGW 267
Query: 816 GGMSLFFYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISFIYIAFGFLGYL 637
LFF G AV++FEG+G+VLPLE++M++ +F + L +GM ++ +YI+ LGY+
Sbjct: 268 KKYPLFF---GTAVFAFEGIGVVLPLENQMRESKRFPQALNIGMAIVTVLYISLATLGYM 324
Query: 636 AFGEDTMDIITANLGAGL-ISTIVQLGLCINLFFTFPLMMNPVFEIV 499
F ++ IT NL + + V++ +F T+ + EI+
Sbjct: 325 CFRDEIKGSITLNLPQDMWLYQSVKILYSFGIFVTYSIQFYVPAEII 371
>sp|Q9H598|VIAAT_HUMAN Vesicular inhibitory amino acid transporter OS=Homo
sapiens GN=SLC32A1 PE=1 SV=2
Length = 525
Score = 56 bits (134), Expect = 6e-007
Identities = 32/78 (41%), Positives = 47/78 (60%)
Frame = -2
Query: 462 LRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQWSLDM 283
LR LV+ L+A++VP+F + L GS T L F+LP+LFHL + ++ W Q D+
Sbjct: 435 LRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQVFFDV 494
Query: 282 AIVGLGVVLAVSGTWSSL 229
AI +G + +VSG SL
Sbjct: 495 AIFVIGGICSVSGFVHSL 512
>sp|Q95KE2|VIAAT_MACFA Vesicular inhibitory amino acid transporter OS=Macaca
fascicularis GN=SLC32A1 PE=2 SV=1
Length = 525
Score = 56 bits (134), Expect = 6e-007
Identities = 32/78 (41%), Positives = 47/78 (60%)
Frame = -2
Query: 462 LRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQWSLDM 283
LR LV+ L+A++VP+F + L GS T L F+LP+LFHL + ++ W Q D+
Sbjct: 435 LRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQVFFDV 494
Query: 282 AIVGLGVVLAVSGTWSSL 229
AI +G + +VSG SL
Sbjct: 495 AIFVIGGICSVSGFVHSL 512
>sp|O35633|VIAAT_MOUSE Vesicular inhibitory amino acid transporter OS=Mus
musculus GN=Slc32a1 PE=1 SV=3
Length = 525
Score = 56 bits (134), Expect = 6e-007
Identities = 32/78 (41%), Positives = 47/78 (60%)
Frame = -2
Query: 462 LRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQWSLDM 283
LR LV+ L+A++VP+F + L GS T L F+LP+LFHL + ++ W Q D+
Sbjct: 435 LRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQVFFDV 494
Query: 282 AIVGLGVVLAVSGTWSSL 229
AI +G + +VSG SL
Sbjct: 495 AIFVIGGICSVSGFVHSL 512
>sp|O35458|VIAAT_RAT Vesicular inhibitory amino acid transporter OS=Rattus
norvegicus GN=Slc32a1 PE=1 SV=1
Length = 525
Score = 56 bits (134), Expect = 6e-007
Identities = 32/78 (41%), Positives = 47/78 (60%)
Frame = -2
Query: 462 LRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQWSLDM 283
LR LV+ L+A++VP+F + L GS T L F+LP+LFHL + ++ W Q D+
Sbjct: 435 LRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQVFFDV 494
Query: 282 AIVGLGVVLAVSGTWSSL 229
AI +G + +VSG SL
Sbjct: 495 AIFVIGGICSVSGFVHSL 512
>sp|Q6DIV6|VIAAT_XENTR Vesicular inhibitory amino acid transporter OS=Xenopus
tropicalis GN=slc32a1 PE=2 SV=1
Length = 518
Score = 56 bits (134), Expect = 6e-007
Identities = 31/78 (39%), Positives = 47/78 (60%)
Frame = -2
Query: 462 LRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQWSLDM 283
LR LV+ L+A++VP+F + L GS T L F+LP+LFHL + ++ W Q D+
Sbjct: 428 LRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLKLLWRKLQWHQVFFDV 487
Query: 282 AIVGLGVVLAVSGTWSSL 229
+I +G + +VSG SL
Sbjct: 488 SIFVIGSICSVSGFVHSL 505
>sp|Q6PF45|VIAAT_XENLA Vesicular inhibitory amino acid transporter OS=Xenopus
laevis GN=slc32a1 PE=2 SV=1
Length = 518
Score = 56 bits (133), Expect = 8e-007
Identities = 31/78 (39%), Positives = 47/78 (60%)
Frame = -2
Query: 462 LRWLLVLAVTLVALFVPNFTDFLSLVGSSTCCILGFVLPALFHLLVFKEEMGWKQWSLDM 283
LR LV+ L+A++VP+F + L GS T L F+LP+LFHL + ++ W Q D+
Sbjct: 428 LRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLKLMWRQLLWHQVFFDV 487
Query: 282 AIVGLGVVLAVSGTWSSL 229
+I +G + +VSG SL
Sbjct: 488 SIFVIGSICSVSGFVHSL 505
>sp|P34579|UNC47_CAEEL Vesicular GABA transporter OS=Caenorhabditis elegans
GN=unc-47 PE=1 SV=2
Length = 486
Score = 55 bits (132), Expect = 1e-006
Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 2/110 (1%)
Frame = -2
Query: 549 NLFFTFPLMMNPVFEIVERRFSGGMYSACLRWLLVLAVTLVALFVPNFTDFLSLVGSSTC 370
NLF +P P S ++ LR +LVL VAL VP + + LVG+ T
Sbjct: 370 NLFLGYP--QTPFTSCYSPDKSLREWAVTLRIILVLFTLFVALSVPYLVELMGLVGNITG 427
Query: 369 CILGFVLPALFHLLVFKEEMGWKQWSLDMAIVGLGVVLAVSGTWSSLSEI 220
+L F+ PALFHL + ++ + + D I+ +G + +SG + S E+
Sbjct: 428 TMLSFIWPALFHLYIKEKTLNNFEKRFDQGIIIMGCSVCISGVYFSSMEL 477
Database: UniProt/SwissProt
Posted date: Sat Aug 07 14:36:18 2010
Number of letters in database: 182,829,261
Number of sequences in database: 518,415
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,294,077,499
Number of Sequences: 518415
Number of Extensions: 99294077499
Number of Successful Extensions: 638971466
Number of sequences better than 0.0: 0
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